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  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: DR Isabelle Foote

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Lawrence JM, Foote IF, Breunig S, Schaffer LS, Lyons S, Abramowitz SA, Levin MG, Damrauer SM et al. ( 2026 ) . Shared Genetic Liability across Systems of Psychiatric and Physical Illness . Nature Communications
Demnitz-King H, Banerjee S, Cooper C, Kenten C, Phillips R, Zabihi S, Birks Y, Brayne C et al. ( 2026 ) . The Nottingham consensus on dementia risk reduction policy: recommendations from a modified Delphi process . Nature Reviews Neurology vol. 22 , ( 2 ) 123 - 135 .
Flint J, Foote I, Ward D, Russ T, Marshall A, Rahman R, Cox S, Luciano M et al. ( 2025 ) . M48. DOMAINS OF FRAILTY AS EARLY RISK FACTORS FOR ALZHEIMER’S DISEASE - TRIANGULATING LONGITUDINAL, GENETIC, AND CAUSAL EVIDENCE . European Neuropsychopharmacology vol. 99 ,
Stirland LE, Choate R, Zanwar PP, Zhang P, Watermeyer TJ, Valletta M, Torso M, Tamburin S et al. ( 2025 ) . Multimorbidity in dementia: Current perspectives and future challenges . Alzheimer's & Dementia vol. 21 , ( 8 )
Foote IF, Flint JP, Fürtjes AE, Lawrence JM, Mullin DS, Fisk JD, Karakach TK, Rutenberg A et al. ( 2025 ) . Uncovering the multivariate genetic architecture of frailty with genomic structural equation modeling . Nature Genetics vol. 57 , ( 8 ) 1848 - 1859 .
Walsh S, Klee M, Hui EK, Saeed U, Waters S, Kuhn I, Siette J, Orgeta V et al. ( 2025 ) . Social determinants of dementia: A scoping review . Alzheimer's & Dementia vol. 21 , ( 7 )
Fürtjes AE, Foote IF, Xia C, Davies G, Moodie J, Taylor A, Liewald DC, Redmond P et al. ( 2025 ) . Measurement characteristics and genome-wide correlates of lifetime brain atrophy estimated from a single MRI . Nature Communications vol. 16 , ( 1 )
Almeida e Sousa I, Grotzinger AD, Lawrence JM, Breunig S, Marshall CR, Korszun A, Foote IF ( 2025 ) . Examining the genetic relationship between Alzheimer’s disease, schizophrenia and their shared risk factors using genomic structural equation modelling . Brain Communications vol. 7 , ( 2 )
Ward DD, Flint JP, Littlejohns TJ, Foote IF, Canevelli M, Wallace LMK, Gordon EH, Llewellyn DJ et al. ( 2025 ) . Frailty Trajectories Preceding Dementia in the US and UK . JAMA Neurology vol. 82 , ( 1 ) 61 - 71 .
Paris A, Amirthalingam G, Karania T, Foote IF, Dobson R, Noyce AJ, Marshall CR, Waters S ( 2025 ) . Depression and dementia: interrogating the causality of the relationship . Journal of Neurology Neurosurgery & Psychiatry vol. 96 , ( 6 ) 573 - 581 .
Foote IF, Flint JP, Fisk JD, Karakach TK, Rutenberg A, Martin NG, Lupton MK, Cox SR et al. ( 2025 ) . Multivariate genomic analyses of frailty reveal the unique importance of cognitive and multimorbidity pathways for aging‐related health outcomes . Alzheimer's & Dementia vol. 20 , ( Suppl 7 )
Farina FR, Bridgeman K, Gregory S, Crivelli L, Foote IF, Jutila O-EI, Kucikova L, Mariano LI et al. ( 2024 ) . Next generation brain health: transforming global research and public health to promote prevention of dementia and reduce its risk in young adult populations . The Lancet Healthy Longevity vol. 5 , ( 12 )
Schaffer LS, Breunig S, Lawrence JM, Foote IF, Grotzinger AD ( 2024 ) . Characterizing genetic pathways unique to autism spectrum disorder at multiple levels of biological analysis . Molecular Autism vol. 15 , ( 1 )
Chiesa ST, Rader L, Garfield V, Foote I, Suri S, Davey Smith G, Hughes AD, Richardson TG ( 2024 ) . Childhood adiposity underlies numerous adult brain traits commonly attributed to midlife obesity . Brain vol. 148 , ( 1 ) 133 - 142 .
Breunig S, Lawrence JM, Foote IF, Gebhardt HJ, Willcutt EG, Grotzinger AD ( 2024 ) . Examining Differences in the Genetic and Functional Architecture of Attention-Deficit/Hyperactivity Disorder Diagnosed in Childhood and Adulthood . Biological Psychiatry Global Open Science vol. 4 , ( 3 )
Foote IF, Bandres‐Ciga S, Kim JJ, Alvarado CX, Leonard HL, Bothongo PL, Grotzinger AD, Jacobs BM et al. ( 2023 ) . A Multivariate Genome‐Wide Association Study of the Shared Genetic Architecture Among Modifiable Risk Factors for Dementia: 590 Loci Associated with Brain Health . Alzheimer's & Dementia vol. 19 , ( S22 )
Lawrence JM, Breunig S, Foote IF, Tallis CB, Grotzinger AD ( 2023 ) . Genomic SEM applied to explore etiological divergences in bipolar subtypes . Psychological Medicine vol. 54 , ( 6 ) 1152 - 1159 .
Newby D, Orgeta V, Marshall CR, Lourida I, Albertyn CP, Tamburin S, Raymont V, Veldsman M et al. ( 2023 ) . Artificial intelligence for dementia prevention . Alzheimer's & Dementia vol. 19 , ( 12 ) 5952 - 5969 .
Bettencourt C, Skene N, Bandres‐Ciga S, Anderson E, Winchester LM, Foote IF, Schwartzentruber J, Botia JA et al. ( 2023 ) . Artificial intelligence for dementia genetics and omics . Alzheimer's & Dementia vol. 19 , ( 12 ) 5905 - 5921 .
LIU H, Dehestani M, Blauwendraat C, Makarious MB, Leonard H, Kim JJ, Schulte C, Noyce A et al. ( 2023 ) . Polygenic resilience inheritance modulates the penetrance of Parkinson’s disease genetic risk factors . Parkinsonism & Related Disorders vol. 113 ,
Sleiman PM, Qu H, Connolly JJ, Mentch F, Pereira A, Lotufo PA, Tollman S, Choudhury A et al. ( 2023 ) . Trans‐ethnic genomic informed risk assessment for Alzheimer's disease: An International Hundred K+ Cohorts Consortium study . Alzheimer's & Dementia vol. 19 , ( 12 ) 5765 - 5772 .
Leonard HL, Murtadha R, Martinez-Carrasco A, Jama A, Müller-Nedebock AC, Gil-Martinez A-L, Illarionova A, Moore A et al. ( 2023 ) . Author Correction: The IPDGC/GP2 Hackathon - an open science event for training in data science, genomics, and collaboration using Parkinson’s disease data . npj Parkinson's Disease vol. 9 , ( 1 )
Leonard HL, Murtadha R, Martinez-Carrasco A, Jama A, Müller-Nedebock AC, Gil-Martinez A-L, Illarionova A, Moore A et al. ( 2023 ) . The IPDGC/GP2 Hackathon - an open science event for training in data science, genomics, and collaboration using Parkinson’s disease data . npj Parkinson's Disease vol. 9 , ( 1 )
Ranson JM, Bucholc M, Lyall D, Newby D, Winchester L, Oxtoby NP, Veldsman M, Rittman T et al. ( 2023 ) . Harnessing the potential of machine learning and artificial intelligence for dementia research . Brain Informatics vol. 10 , ( 1 )
Ranson JM, Al Khleifat A, Lyall DM, Newby D, Winchester LM, Veldsman M, Rittman T, Marzi S et al. ( 2022 ) . The Deep Dementia Phenotyping (DEMON) Network: A global platform for innovation using data science and artificial intelligence . Alzheimer's & Dementia vol. 18 , ( S2 )
Ranson JM, Bucholc M, Lyall D, Newby D, Winchester L, Oxtoby N, Veldsman M, Rittman T et al. ( 2022 ) . The Emerging Role of AI in Dementia Research and Healthcare . Artificial Intelligence in Healthcare , Springer Nature
Paris A, Amirthalingam G, Karania T, Dey S, Foote I, Bothongo P, Dobson R, Noyce A et al. ( 2022 ) . 043 Depression is associated with increased dementia risk and reduced grey matter in a fronto-insular-cerebellar network . Journal of Neurology Neurosurgery & Psychiatry vol. 93 , ( 9 )
Liu H, Dehestani M, Blauwendraat C, Makarious MB, Leonard H, Kim JJ, Schulte C, Noyce A et al. ( 2022 ) . Polygenic Resilience Modulates the Penetrance of Parkinson Disease Genetic Risk Factors . Annals of Neurology vol. 92 , ( 2 ) 270 - 278 .
Foote IF, Jacobs BM, Mathlin G, Watson CJ, Bothongo PL, Waters S, Dobson R, Noyce AJ et al. ( 2022 ) . The shared genetic architecture of modifiable risk for Alzheimer's disease: a genomic structural equation modelling study . Neurobiology of Aging vol. 117 , 222 - 235 .
Watson C, Waters S, Jacobs B, Foote I, Dey S, Noyce A, Marshall C ( 2022 ) . 003  Neuroanatomical signatures of genetic risk for Alzheimer’s disease in healthy adults . Journal of Neurology Neurosurgery & Psychiatry vol. 93 , ( 6 ) a101.3 - a1a102 .
Bothongo P, Jitlal M, Parry E, Foote I, Waters S, Dobson R, Noyce A, Bestwick J et al. ( 2022 ) . Ethnic and socioeconomic determinants of dementia risk: a nested case-con- trol study in East London . Journal of Neurology Neurosurgery & Psychiatry vol. 93 , ( 6 ) a8.2 - a8a8 .
Watson CJ, Waters S, Jacobs BM, Foote IF, Dey S, Noyce AJ, Hardy CJD, Marshall CR ( 2022 ) . Speech-in-noise perception is a marker of preclinical Alzheimer’s disease . Journal of Neurology Neurosurgery & Psychiatry vol. 93 , ( 6 ) a91.1 - a9a91 .
Bothongo PLK, Jitlal M, Parry E, Waters S, Foote IF, Watson CJ, Cuzick J, Giovannoni G et al. ( 2022 ) . Dementia risk in a diverse population: A single-region nested case-control study in the East End of London . The Lancet Regional Health - Europe vol. 15 ,
Waters S, Watson C, Jacobs BM, Foote IF, Dey S, Noyce AJ, Marshall CR ( 2022 ) . Neuroanatomical signatures of genetic risk for Alzheimer's disease in healthy adults . Alzheimer's & Dementia vol. 17 , ( S4 )
Waters S, Watson C, Jacobs BM, Foote IF, Dey S, Noyce AJ, Marshall CR ( 2021 ) . Speech‐in‐noise perception is a marker of preclinical Alzheimer’s disease . Alzheimer's & Dementia vol. 17 , ( S5 )
Foote I, Jacobs B, Watson C, Bothongo P, Waters S, Dobson R, Noyce A, Bhui K et al. ( 2021 ) . W26. A MULTIVARIATE GENOME-WIDE ASSOCIATION STUDY OF MODIFIABLE RISK FOR ALZHEIMER'S DISEASE: 269 LOCI ASSOCIATED WITH BRAIN HEALTH . European Neuropsychopharmacology vol. 51 ,
Elsayed I ( 2021 ) . Improving Diversity in Parkinson's Disease Genetics: Findings from the First‐Ever Genome‐Wide Association Study in Latinos . Movement Disorders vol. 36 , ( 11 ) 2505 - 2505 .
Foote IF, Jacobs BM, Mathlin G, Watson CJ, Bothongo PL, Waters S, Dobson R, Noyce AJ et al. ( 2021 ) . The Genetic Architecture of Alzheimer’s Disease Risk: A Genomic Structural Equation Modelling Study .
Bothongo PL, Jitlal M, Parry E, Foote IF, Waters S, Dobson R, Noyce AJ, Bestwick JP et al. ( 2020 ) . Ethnic and socioeconomic determinants of dementia risk: A nested case‐control study in the population of East London . Alzheimer's & Dementia vol. 16 , ( S10 )
Foote IF, Jacobs BM, Noyce AJ, Korszun A, Bhui KS, Marshall CR ( 2020 ) . Exploring the shared genetic architecture of modifiable risk factors and related endophenotypes of Alzheimer’s disease: A genomic SEM study . Alzheimer's & Dementia vol. 16 , ( S2 )
Schaffer LS, Breunig S, Lawrence JM, Foote IF, Grotzinger AD . Characterizing Genetic Pathways Unique to Autism Spectrum Disorder at Multiple Levels of Biological Analysis .
Flint JP, Foote IF, Ward DD, Russ TC, Marshall A, Rahman R, Cox SR, Luciano M et al. . Domains of Frailty as Early Risk Factors for Alzheimer Dementia - Genetic and Causal Evidence .
Breunig S, Lawrence JM, Foote IF, Gebhardt HJ, Willcutt EG, Grotzinger AD . Examining Differences in the Genetic and Functional Architecture of ADHD Diagnosed in Childhood and Adulthood .
Ward D, Flint J, Littlejohns T, Foote I, Canevelli M, Wallace L, Gordon E, Llewellyn D et al. . Frailty trajectories preceding dementia: an individual-level analysis of four cohort studies in the United States and United Kingdom .
Lawrence JM, Breunig S, Foote IF, Tallis CB, Grotzinger AD . Genomic SEM Applied to Explore Etiological Divergences in Bipolar Subtypes .
Fürtjes AE, Foote IF, Xia C, Davies G, Moodie J, Taylor A, Liewald DC, Redmond P et al. . Lifetime brain atrophy estimated from a single MRI: measurement characteristics and genome-wide correlates .
Lawrence JM, Foote IF, Breunig S, Schaffer LS, Mallard TT, Grotzinger AD . Shared Genetic Liability across Systems of Psychiatric and Physical Illness .
Leonard HL, Murtadha R, Martinez-Carrasco A, Muller-Nedebock A, Gil-Martinez A-L, Illarionova A, Moore A, Bustos BI et al. . The IPDGC/GP2 Hackathon - an open science event for training in data science, genomics, and collaboration using Parkinson’s disease data .
Jacobs BM, Chandra A, Mandal A, Foote I, Durrani F, Waters S, Liu Y, Proitsi P et al. . The contribution of Apoliproprotein E genetic variation to dementia risk in British South Asians .
Sleiman PM, Qu H-Q, Connolly JJ, Mentch F, Pereira A, Lotufo PA, Tollman S, Choudhury A et al. . Trans-ethnic Genomic Informed Risk Assessment for Alzheimer’s disease: An International Hundred K+ Cohorts Consortium Study .
Foote IF, Flint JP, Fürtjes AE, Mullin DS, Fisk JD, Karakach TK, Rutenberg A, Martin NG et al. . Uncovering the multivariate genetic architecture of frailty with genomic structural equation modelling .
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