Publications: DR Karine Rizzoti

Calleja V, Henry JC, Cobbaut M, Sewell J, Rizzoti K, Houghton F, Boeing S, Anyanwu N et al. ( 2025 ) . The chordoid glioma PRKCA D463H mutation is a kinase inactive, gain-of-function allele that induces early-onset chondrosarcoma in mice . Science Signaling vol. 18 , ( 911 ) eadr0235 - eadr0235 .

Sheridan D, Chakravarty P, Golan G, Shiakola Y, Olsen J, Burnett E, Galichet C, Fiordelisio T et al. ( 2025 ) . Gonadotrophs have a dual origin, with most derived from early postnatal pituitary stem cells . Nature Communications vol. 16 , ( 1 )

Das P, Jabal DA, Sunny DA, Kittu PS, Rizzoti K, Ellsworth BS ( 2024 ) . 9264 The interplay of FOXO1 and NR3C1 in the development and function of pituitary somatotropes . Journal of the Endocrine Society vol. 8 , ( Supplement_1 )

Galichet C, Rizzoti K, Lovell-Badge R ( 2024 ) . Hypopituitarism in Sox3 null mutants correlates with altered NG2-glia in the median eminence and is influenced by aspirin and gut microbiota . PLOS Genetics vol. 20 , ( 9 )

Rizzoti K, Lovell-Badge R, Chakravarty P, Sheridan D ( 2024 ) . SOX9-positive pituitary stem cells differ according to their position in the gland and maintenance of their progeny depends on context . Endocrine Abstracts

Rizzoti K, Chakravarty P, Sheridan D, Lovell-Badge R ( 2023 ) . SOX9-positive pituitary stem cells differ according to their position in the gland and maintenance of their progeny depends on context . Science Advances vol. 9 , ( 40 )

Chen Q, Leshkowitz D, Li H, van Impel A, Schulte-Merker S, Amit I, Rizzoti K, Levkowitz G ( 2023 ) . Neural plate progenitors give rise to both anterior and posterior pituitary cells . Developmental Cell vol. 58 , ( 23 ) 2652 - 2665.e6 .

Cheung LYM, Menage L, Rizzoti K, Hamilton G, Dumontet T, Basham K, Daly AZ, Brinkmeier ML et al. ( 2023 ) . Novel Candidate Regulators and Developmental Trajectory of Pituitary Thyrotropes . Endocrinology vol. 164 , ( 6 )

Caramello A, Galichet C, Sopena ML, Lovell‐Badge R, Rizzoti K ( 2022 ) . The cortical hem lacks stem cell potential despite expressing SOX9 and HOPX . Developmental Neurobiology vol. 82 , ( 7-8 ) 565 - 580 .

Saenz-Antoñanzas A, Moncho-Amor V, Elúa-Pinín A, Rizzoti K, Lovell-Badge R, Matheu A ( 2022 ) . P02.10.A CRISPR/Cas9 deletion of SOX2 Regulatory Region 2 (SRR2) decreases SOX2 malignant activity in glioblastoma . Neuro-Oncology vol. 24 , ( Supplement_2 ) ii31 - ii31 .

Bezen D, Kutlu O, Mouilleron S, Rizzoti K, Dattani M, Guran T, Yeşil G ( 2022 ) . A homozygous Y443C variant in the RNPC3 is associated with severe syndromic congenital hypopituitarism and diffuse brain atrophy . American Journal of Medical Genetics Part A vol. 188 , ( 9 ) 2701 - 2706 .

Akin L, Rizzoti K, Gregory LC, Corredor B, Le Quesne Stabej P, Williams H, Buonocore F, Mouilleron S et al. ( 2021 ) . Pathogenic variants in RNPC3 are associated with hypopituitarism and primary ovarian insufficiency . Genetics in Medicine vol. 24 , ( 2 ) 384 - 397 .

Fontaine R, Rizzoti K, Weltzien F-A ( 2021 ) . Editorial: Plasticity in the Vertebrate Pituitary, Including Regulatory Mechanisms . Frontiers in Endocrinology vol. 12 ,

Moncho-Amor V, Chakravarty P, Galichet C, Lovell-Badge R, Rizzoti K ( 2021 ) . Sox2 Is Required Independently in Both Stem and Differentiated Cells for Pituitary Tumour Genesis in P27 Null Mice . Journal of the Endocrine Society vol. 5 , ( Supplement_1 ) a510 - a510 .

Saenz-Antoñanzas A, Moncho-Amor V, Auzmendi-Iriarte J, Elua-Pinin A, Rizzoti K, Lovell-Badge R, Matheu A ( 2021 ) . CRISPR/Cas9 Deletion of SOX2 Regulatory Region 2 (SRR2) Decreases SOX2 Malignant Activity in Glioblastoma . Cancers vol. 13 , ( 7 )

Moncho-Amor V, Chakravarty P, Galichet C, Matheu A, Lovell-Badge R, Rizzoti K ( 2021 ) . SOX2 is required independently in both stem and differentiated cells for pituitary tumorigenesis in p27-null mice . Proceedings of the National Academy of Sciences of the United States of America vol. 118 , ( 7 )

Caramello A, Galichet C, Rizzoti K, Lovell-Badge R ( 2021 ) . Dentate gyrus development requires a cortical hem-derived astrocytic scaffold . eLife vol. 10 ,

Cheung LYM, Rizzoti K ( 2020 ) . Cell population characterisation and discovery using single cell technologies in endocrine systems . Journal of Molecular Endocrinology vol. -1 , ( aop ) r35 - r51 .

Gaynor KU, Grigorieva IV, Mirczuk SM, Piret SE, Kooblall KG, Stevenson M, Rizzoti K, Bowl MR et al. ( 2020 ) . Studies of mice deleted for Sox3 and uc482: relevance to X-linked hypoparathyroidism . Endocrine Connections vol. -1 , ( aop ) 173 - 186 .

Mistry A, Solomou A, Vignola ML, Lim CT, Herincs M, Caimari F, Gualtieri A, Rizzoti K ( 2019 ) . Investigating the role of AIP in pituitary tumourigenesis . Endocrine Abstracts

Rizzoti K ( 2019 ) . Single cell technologies in endocrine systems . Endocrine Abstracts

L C, P LT, SG G, M T, R L-B, K R ( 2018 ) . NOTCH activity differentially affects alternative cell fate acquisition and maintenance .

Rizzoti K ( 2018 ) . Single-cell technologies in development and disease with a special emphasis on endocrine systems . Endocrine Abstracts

Cheung L, Le Tissier P, Goldsmith SG, Treier M, Lovell-Badge R, Rizzoti K ( 2018 ) . NOTCH activity differentially affects alternative cell fate acquisition and maintenance . eLife vol. 7 ,

Rizzoti K, Lovell-Badge R ( 2016 ) . Pivotal role of median eminence tanycytes for hypothalamic function and neurogenesis . Molecular and Cellular Endocrinology vol. 445 , 7 - 13 .

Rizzoti K, Pires C, Lovell-Badge R ( 2016 ) . Perspective on Stem Cells in Developmental Biology, with Special Reference to Neuroendocrine Systems . Stem Cells in Neuroendocrinology , Springer Nature

Moncho-Amor V, Garros L, Galichet C, Rizzoti K, Matheu M, Lovell-Badge R ( 2016 ) . 468 Functional characterization of the interaction between the stem cell factor SOX2 and the cell cycle regulator P27 in normal and cancerous stem cells . European Journal of Cancer vol. 61 ,

Goldsmith S, Lovell-Badge R, Rizzoti K ( 2016 ) . SOX2 is sequentially required for progenitor proliferation and lineage specification in the developing pituitary . Development vol. 143 , ( 13 ) 2376 - 2388 .

Rizzoti K, Lovell-Badge R ( 2016 ) . Chapter 14 Role of SOX2 in the Hypothalamo–Pituitary Axis . Sox2 , Elsevier

Rizzoti K ( 2015 ) . Genetic regulation of murine pituitary development . Journal of Molecular Endocrinology vol. 54 , ( 2 ) r55 - r73 .

Yoshida M, Uchikawa M, Rizzoti K, Lovell-Badge R, Takemoto T, Kondoh H ( 2014 ) . Regulation of mesodermal precursor production by low-level expression of B1 Sox genes in the caudal lateral epiblast . Cells and Development vol. 132 , 59 - 68 .

Rizzoti K, Akiyama H, Lovell-Badge R ( 2013 ) . Mobilized Adult Pituitary Stem Cells Contribute to Endocrine Regeneration in Response to Physiological Demand . Cell Stem Cell vol. 13 , ( 4 ) 419 - 432 .

Lee B, Song H, Rizzoti K, Son Y, Yoon J, Baek K, Jeong Y ( 2013 ) . Genomic code for Sox2 binding uncovers its regulatory role in Six3 activation in the forebrain . Developmental Biology vol. 381 , ( 2 ) 491 - 501 .

Cheung LYM, Rizzoti K, Lovell‐Badge R, Le Tissier PR ( 2013 ) . Pituitary Phenotypes of Mice Lacking the Notch Signalling Ligand Delta‐Like 1 Homologue . Journal of Neuroendocrinology vol. 25 , ( 4 ) 391 - 401 .

Li H, Collado M, Villasante A, Matheu A, Lynch CJ, Cañamero M, Rizzoti K, Carneiro C et al. ( 2012 ) . p27Kip1 Directly Represses Sox2 during Embryonic Stem Cell Differentiation . Cell Stem Cell vol. 11 , ( 6 ) 845 - 852 .

Lee B, Rizzoti K, Kwon DS, Kim S-Y, Oh S, Epstein DJ, Son Y, Yoon J et al. ( 2012 ) . Direct transcriptional regulation of Six6 is controlled by SoxB1 binding to a remote forebrain enhancer . Developmental Biology vol. 366 , ( 2 ) 393 - 403 .

Mollard P, Hodson DJ, Lafont C, Rizzoti K, Drouin J ( 2012 ) . A tridimensional view of pituitary development and function . Trends in Endocrinology and Metabolism vol. 23 , ( 6 ) 261 - 269 .

Zhao L, Zevallos SE, Rizzoti K, Jeong Y, Lovell-Badge R, Epstein DJ ( 2012 ) . Disruption of SoxB1-Dependent Sonic hedgehog Expression in the Hypothalamus Causes Septo-optic Dysplasia . Developmental Cell vol. 22 , ( 3 ) 585 - 596 .

Rizzoti K, Lovell-Badge R ( 2012 ) . Nature Digest . Nature Digest vol. 9 , ( 3 ) 24 - 26 .

Paquereau L, Devic E, Knibiehler B, Rizzoti K, Monier A, Audigier S, Dupont H, Brethous M et al. ( 2012 ) . Transduction systems and early embryogenesis . Biology of the Cell vol. 84 , ( 1‐2 ) 87 - 87 .

Lee K, Tan J, Morris MB, Rizzoti K, Hughes J, Cheah PS, Felquer F, Liu X et al. ( 2012 ) . Congenital Hydrocephalus and Abnormal Subcommissural Organ Development in Sox3 Transgenic Mice . PLOS ONE vol. 7 , ( 1 )

Rizzoti K, Lovell-Badge R ( 2011 ) . Organ recital in a dish . Nature vol. 480 , ( 7375 ) 44 - 46 .

Acloque H, Ocaña OH, Matheu A, Rizzoti K, Wise C, Lovell-Badge R, Nieto MA ( 2011 ) . Reciprocal Repression between Sox3 and Snail Transcription Factors Defines Embryonic Territories at Gastrulation . Developmental Cell vol. 21 , ( 3 ) 546 - 558 .

Sutton E, Hughes J, White S, Sekido R, Tan J, Arboleda V, Rogers N, Knower K et al. ( 2010 ) . Identification of SOX3 as an XX male sex reversal gene in mice and humans . Journal of Clinical Investigation vol. 121 , ( 1 ) 328 - 341 .

Rizzoti K ( 2010 ) . Adult pituitary progenitors/stem cells: from in vitro characterization to in vivo function . European Journal of Neuroscience vol. 32 , ( 12 ) 2053 - 2062 .

Galichet C, Lovell-Badge R, Rizzoti K ( 2010 ) . Nestin-Cre Mice Are Affected by Hypopituitarism, Which Is Not Due to Significant Activity of the Transgene in the Pituitary Gland . PLOS ONE vol. 5 , ( 7 )

Kelberman D, Rizzoti K, Lovell-Badge R, Robinson ICAF, Dattani MT ( 2009 ) . Genetic Regulation of Pituitary Gland Development in Human and Mouse . Endocrine Reviews vol. 30 , ( 7 ) 790 - 829 .

Galichet C, Rizzoti K, Lovell-Badge R ( 2009 ) . 07-P021 Sox3 deletion in the central nervous system affects pituitary endocrine cell size . Cells and Development vol. 126 , s142 - s143 .

Rizzoti K ( 2009 ) . 17-P010 A population of stem cells/progenitors in the adult pituitary gland . Cells and Development vol. 126 , s273 - s274 .

Fauquier T, Rizzoti K, Dattani M, Lovell-Badge R, Robinson ICAF ( 2008 ) . SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland . Proceedings of the National Academy of Sciences of the United States of America vol. 105 , ( 8 ) 2907 - 2912 .

Kelberman D, de Castro SCP, Huang S, Crolla JA, Palmer R, Gregory JW, Taylor D, Cavallo L et al. ( 2008 ) . SOX2 Plays a Critical Role in the Pituitary, Forebrain, and Eye during Human Embryonic Development . The Journal of Clinical Endocrinology & Metabolism vol. 93 , ( 5 ) 1865 - 1873 .

Rizzoti K, Lovell-Badge R ( 2007 ) . SOX3 activity during pharyngeal segmentation is required for craniofacial morphogenesis . Development vol. 134 , ( 19 ) 3437 - 3448 .

Kelberman D, Rizzoti K, Avilion A, Bitner-Glindzicz M, Cianfarani S, Collins J, Chong WK, Kirk JMW et al. ( 2006 ) . Mutations within Sox2/SOX2 are associated with abnormalities in the hypothalamo-pituitary-gonadal axis in mice and humans . Journal of Clinical Investigation vol. 116 , ( 9 ) 2442 - 2455 .

Bowl MR, Nesbit MA, Harding B, Levy E, Jefferson A, Volpi E, Rizzoti K, Lovell-Badge R et al. ( 2005 ) . An interstitial deletion-insertion involving chromosomes 2p25.3 and Xq27.1, near SOX3, causes X-linked recessive hypoparathyroidism . Journal of Clinical Investigation vol. 115 , ( 10 ) 2822 - 2831 .

Rizzoti K, Lovell-Badge R ( 2005 ) . Early Development of the Pituitary Gland: Induction and Shaping of Rathke’s Pouch . Reviews in Endocrine and Metabolic Disorders vol. 6 , ( 3 ) 161 - 172 .

Woods KS, Cundall M, Turton J, Rizotti K, Mehta A, Palmer R, Wong J, Chong WK et al. ( 2005 ) . Over- and Underdosage of SOX3 Is Associated with Infundibular Hypoplasia and Hypopituitarism . American Journal of Human Genetics vol. 76 , ( 5 ) 833 - 849 .

Rizzoti K, Brunelli S, Carmignac D, Thomas PQ, Robinson IC, Lovell-Badge R ( 2004 ) . SOX3 is required during the formation of the hypothalamo-pituitary axis . Nature Genetics vol. 36 , ( 3 ) 247 - 255 .

Devic E, Rizzoti K, Bodin S, Knibiehler B, Audigier Y ( 1999 ) . Amino acid sequence and embryonic expression of msr/apj, the mouse homolog of Xenopus X-msr and human APJ . Cells and Development vol. 84 , ( 1-2 ) 199 - 203 .

Devic E, Rizzoti K, Bodin S, Paquereau L, Knibiehler B, Audigier Y ( 1999 ) . Expression of a new family of receptors similar to CXC chemokine receptors in endothelial cell precursors . Current Research in Translational Medicine vol. 47 , ( 4 ) 330 - 338 .

Rizzoti K, Paquereau L, Shaw A, Knibiehler B, Audigier Y ( 1998 ) . A constitutively activated mutant of Gαq down-regulates EP-cadherin expression and decreases adhesion between ectodermal cells at gastrulation . Cells and Development vol. 76 , ( 1-2 ) 19 - 31 .

Devic E, Paquereau L, Rizzoti K, Monier A, Knibiehler B, Audigier Y ( 1996 ) . The mRNA encoding a β subunit of heterotrimeric GTP-binding proteins is localized to the animal pole of Xenopus laevis oocyte and embryos . Cells and Development vol. 59 , ( 2 ) 141 - 151 .

Caramello A, Galichet C, Rizzoti K, Lovell-Badge R . Dentate gyrus development requires a cortical hem-derived astrocytic scaffold .

Sheridan D, Chakravarty P, Golan G, Shiakola Y, Olsen J, Burnett E, Galichet C, Mollard P et al. . Gonadotrophs have a dual origin, with most derived from pituitary stem cells during minipuberty .

Chen Q, Leshkowitz D, Li H, van Impel A, Schulte-Merker S, Amit I, Rizzoti K, Levkowitz G . Neural plate progenitors give rise to both anterior and posterior pituitary cells .

Moncho-Amor V, Chakravarty P, Galichet C, Matheu A, Lovell-Badge R, Rizzoti K . SOX2 is required independently in both stem and differentiated cells for pituitary tumorigenesis in p27 null mice .

Rizzoti K, Chakravarty P, Sheridan D, Lovell-Badge R . SOX9-positive pituitary stem cells differ according to their position in the gland and maintenance of their progeny depends on context .

Galichet C, Rizzoti K, Lovell-Badge R . Sox3-null hypopituitarism depends on median eminence NG2-glia and is influenced by aspirin and gut microbiota .

Calleja V, Henry JC, Cobbaut M, Sewell J, Rizzoti K, Houghton F, Boeing S, Anyanwu N et al. . The penetrant chordoid glioma PRKCA mutation is an oncogenic gain-of-function kinase inactivation eliciting early onset chondrosarcoma in mice .