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Research

Publications: DR Amit Roshan

Hessey S, Bunkum A, Huebner A, Haase K, Grigoriadis K, Naceur-Lombardelli C, Liu WK, Harrigan CF et al. ( 2026 ) . Evolutionary characterization of lung cancer metastasis . Nature vol. 653 , ( 8115 ) 911 - 922 .
Zhou Z, Cutts R, Hrebien S, Zhang CX, Garcia‑Murillas I, Zhang WZ, Frankell AM, Cooper WN et al. ( 2026 ) . ctDNA monitoring using tumor-informed copy number analysis . EMBO Molecular Medicine vol. 18 , ( 4 ) 1429 - 1455 .
Mithra S, Amato F, Gomes C, Ahmed A, van Schelt A-S, Cherukara M, Rowley M, Coolen T et al. ( 2026 ) . 298 HERD: Towards integration of advanced MRI and multi-omic biomarkers for early relapse prediction in high-risk head and neck cancer-a prospective study . Radiotherapy and Oncology vol. 216 , s38 - s40 .
Roshan A, Pasha T, Kounidas G, O'Leary F, Murphy S, Tajsic T, Patel A, Aloj L et al. ( 2026 ) . A-197 99Tc-Tilmanocept sentinel node biopsy and long-term outcomes in melanoma . EJC Skin Cancer vol. 4 ,
Milan-Chhatrisha B, Benhamida A, Roshan A ( 2026 ) . A-603 Influence of body mass index on cutaneous clinical stage I/II melanoma: risk of micrometastasis and influence on long-term outcomes . EJC Skin Cancer vol. 4 ,
Clay B, Manton R, Kiely J, Patel A, Roshan A ( 2026 ) . Long-term outcomes of cutaneous basal cell and squamous cell carcinomas with < 1 mm close primary surgical excision margins managed in a UK tertiary centre multidisciplinary team . EJC Skin Cancer vol. 4 ,
Javaid A, Cheruvu S, Corrie PG, Edmonds K, Laing A, Larkin J, Lee R, Mair R et al. ( 2025 ) . 75eTiP PerceIVe: Power of liquid biopsy tracking in immunotherapy treated unresectable stage III and stage IV melanoma . Immuno-Oncology Technology vol. 28 ,
Flach S, Surani A, Zhou Z, Zhao H, Mennea P, Talukdar F, McAndrew G, Greger C et al. ( 2025 ) . Abstract 3775: Liquid biopsy for therapy planning in clinically N0 head and neck cancer (LiC0HN) - A personalized cell-free tumor DNA analysis for patients with HNSCC . Cancer Research vol. 85 , ( 8_Supplement_1 ) 3775 - 3775 .
Roshan A, Talukdar FR, An A, Ditter E-J, Zhou Z, Mennea PD, Wu L, Neofytou MC et al. ( 2025 ) . Abstract 4550: Dried blood sot sampling as a minimally invasive and accessible method for investigating circulating tumor DNA in diverse cancer settings . Cancer Research vol. 85 , ( 8_Supplement_1 ) 4550 - 4550 .
Cheng Z, McDonald S, Thomas H, Zhou Z, Mennea P, Haichao wang, Shcherbo D, Zhang C et al. ( 2025 ) . Abstract 4631: Deciphering immunotherapy response variability and immune-related toxicities through longitudinal multimodal ctDNA analysis in advanced melanoma . Cancer Research vol. 85 , ( 8_Supplement_1 ) 4631 - 4631 .
de Jager VD, Giacomini P, Fairley JA, Toledo RA, Patton SJ, Joosse SA, Koch C, Deans ZC et al. ( 2025 ) . Reporting of molecular test results from cell-free DNA analyses: expert consensus recommendations from the 2023 European Liquid Biopsy Society ctDNA Workshop . EBioMedicine vol. 114 ,
Else TR, Loreno C, Gröhl J, Groves A, Roshan A, Bohndiek SE ( 2025 ) . Physics-based skin color bias correction for equitable photoacoustic imaging (Conference Presentation) . Conference: Photons Plus Ultrasound: Imaging and Sensing 2025
Azizi A, Linossi C, Machin A, Dayimu A, Demiris N, Miremadi A, O'Donovan M, Godfrey E et al. ( 2025 ) . Abstract B064: Utility of ctDNA assessment after six weeks of immunotherapy to predict radiological response in advanced esophageal cancer . Cancer Immunology Research vol. 13 , ( 2_Supplement ) b064 - b064 .
Clay B, Manton R, Kiely J, Patel A, Roshan A ( 2025 ) . A-247 Long-term local recurrence and further primary skin cancers in cutaneous basal cell carcinoma with involved or close primary excision margins . EJC Skin Cancer vol. 3 ,
Clay B, Manton R, Kiely J, Patel A, Roshan A ( 2025 ) . A-534 Long-term recurrence and disease specific mortality in cutaneous squamous cell carcinoma with involved or close primary excision margins . EJC Skin Cancer vol. 3 ,
Neofytou MC, Cheng Z, Mennea PD, Ditter E-J, An A, Wang H, Cooper WN, Zhao H et al. ( 2025 ) . A-630 Detecting circulating tumor DNA in archived whole blood samples in patients undergoing treatment for primary cutaneous melanoma . EJC Skin Cancer vol. 3 ,
Strazda AE, Laouris P, Luxhøj CM, Kounidas G, Patel AJ, Durrani AJ, Roshan A ( 2025 ) . Does the interval between melanoma diagnosis and surgery have an impact on outcomes? A systematic review and meta-analysis . EJC Skin Cancer vol. 3 ,
Kounidas G, Strazda AE, Pasha T, Roshan A ( 2025 ) . Sentinel lymph node biopsy for cutaneous melanoma performed within 6 weeks of diagnostic excision compared to those performed at longer time intervals in a UK cohort . EJC Skin Cancer vol. 3 ,
Manton RN, Roshan A ( 2024 ) . Systematic review of risk prediction tools for primary cutaneous melanoma outcomes and validation of sentinel lymph node positivity prediction in a UK tertiary cohort . BJC Reports vol. 2 , ( 1 )
Roshan A, Pasha T, Kounidas G, Murphy S, Aloj L, Buscombe J, Patel A, Durrani A ( 2024 ) . Next day sentinel node biopsy for melanoma after lymphoscintigraphy using 99mTc-labelled nanocolloid does not adversely affect long-term outcomes . Annals of Nuclear Medicine vol. 39 , ( 1 ) 77 - 85 .
Forster M, Mithra S, Ng T, Rosenfeld N, Sawyer E, Reis Ferreira M, Sinkus R, Shmueli K et al. ( 2024 ) . HERD: A multi-centre prospective cohort study to facilitate early detection of relapse in radically treated, high risk head and neck squamous cell carcinoma . Journal of Clinical Oncology vol. 42 , ( 16_suppl ) tps6128 - tps6128 .
Chan K, Chan J, Roshan A ( 2024 ) . Incidental Breast Cancer Diagnosis From Lymphoscintography Using 99mTc-Labeled Nanocolloid for Cutaneous Melanoma of the Upper Arm . Clinical Nuclear Medicine vol. 49 , ( 8 ) 748 - 749 .
Roshan A, Shah B, Anderson KD, Murphy S, Thomas B, McPhee AS, Lamb BW, Durrani AJ et al. ( 2024 ) . ASO Visual Abstract: Robot-Assisted Pelvic Dissection for Enlarged Lymph Nodes in Melanoma Improves Recovery with Equivalent Oncological Outcomes to Open Pelvic Dissection . Annals of Surgical Oncology vol. 31 , ( 4 ) 2747 - 2748 .
Roshan A, Shah B, Anderson KD, Murphy S, Thomas B, McPhee AS, Lamb BW, Durrani AJ et al. ( 2024 ) . Robot-Assisted Pelvic Dissection for Enlarged Lymph Nodes in Melanoma Improves Recovery with Equivalent Oncological Outcomes to Open Pelvic Dissection . Annals of Surgical Oncology vol. 31 , ( 4 ) 2727 - 2736 .
Jones O, Murphy S, Durrani A, Roshan A ( 2024 ) . A-300 Lymph Node Operative Experience in the UK – What’s Changed? . EJC Skin Cancer vol. 2 ,
Strazda AE, Laouris P, Luxhoj CM, Patel A, Durrani A, Roshan A ( 2024 ) . A-378 Does the interval between melanoma diagnosis and surgery have an impact on outcomes? A systematic review and meta-analysis . EJC Skin Cancer vol. 2 ,
Manton R, Roshan A ( 2024 ) . A-393 Assessment of performance in clinical risk prediction tools for cutaneous melanoma in the UK population . EJC Skin Cancer vol. 2 ,
Kounidas G, Strazda A, Pasha T, Roshan A ( 2024 ) . A-407 Time interval between Sentinel Lymph Node Biopsy and Excision of Primary Melanoma does not impact long term outcomes in a large UK cohort . EJC Skin Cancer vol. 2 ,
Denholm M, Martin HW, Roshan A, Miller S, Harden G, Towns C, Kadyan S, Mennea P et al. ( 2023 ) . 235TiP Hamlet.rt Trans: Prospective single-centre translational study evaluating liquid biomarkers of radiation response . Annals of Oncology vol. 34 ,
Pasha T, Roshan A ( 2023 ) . Complex Lymphatic Drainage in Head and Neck Cutaneous Melanoma and SLNB Outcomes—Reply . JAMA Otolaryngology - Head & Neck Surgery vol. 149 , ( 9 ) 854 - 854 .
Pasha T, Arain Z, Buscombe J, Aloj L, Durrani A, Patel A, Roshan A ( 2023 ) . Association of Complex Lymphatic Drainage in Head and Neck Cutaneous Melanoma With Sentinel Lymph Node Biopsy Outcomes . JAMA Otolaryngology - Head & Neck Surgery . vol. 149 , 416 - 423 .
Denholm M, Martin H, Roshan A, Miller S, Harden G, Kadyan S, Towns C, Mennea P et al. ( 2023 ) . 198 Hamlet.rt Trans: a prospective single-centre translational sub-study evaluation of liquid biomarkers of radiation response . Lung Cancer vol. 178 ,
Shah B, Lamb B, Durrani A, Roshan A, Patel A ( 2023 ) . Robot-assisted pelvic node dissection has similar operative and melanoma outcomes to open pelvic node dissection with shorter hospital stays . European Journal of Surgical Oncology vol. 49 , ( 1 ) e16 - e17 .
Manton RN, Norrey M, Roshan A, Durrani AJ, Patel AJK ( 2021 ) . A retrospective analysis of rates of allergic reaction to Patent V blue dye used in sentinel lymph node biopsies for melanoma . Journal of Plastic Reconstructive & Aesthetic Surgery vol. 75 , ( 2 ) 893 - 939 .
Jones O, Murphy SH, Biosse-Duplan G, Patel AJK, Roshan A, Durrani AJ ( 2021 ) . Lymph node dissections in cutaneous malignancy: Where are we now? A review of 10 years’ experience at a tertiary centre . Journal of Plastic Reconstructive & Aesthetic Surgery vol. 74 , ( 11 ) 2993 - 2998 .
Ashcroft J, Murphy S, Laing TA, Durrani AJ, Roshan A ( 2021 ) . A new clinical presentation: breast implant pneumocapsule and pneumothorax following penetrating chest wall trauma . Annals of The Royal College of Surgeons of England vol. 103 , ( 3 ) e98 - e100 .
Fowler JC, King C, Bryant C, Hall MWJ, Sood R, Ong SH, Earp E, Fernandez-Antoran D et al. ( 2021 ) . Selection of Oncogenic Mutant Clones in Normal Human Skin Varies with Body Site . Cancer Discovery vol. 11 , ( 2 ) 340 - 361 .
Kiely J, Roshan A ( 2020 ) . Response to letter regarding: Poorly differentiated cutaneous squamous cell carcinomas have high incomplete excision rates with UK minimum recommended pre-determined surgical margins . Journal of Plastic Reconstructive & Aesthetic Surgery vol. 74 , ( 4 ) 890 - 930 .
Roshan A ( 2019 ) . CORR Insights®: Can Sural Fasciocutaneous Flaps Be Effective in Patients Older Than 65? . Clinical Orthopaedics and Related Research vol. 478 , ( 4 ) 739 - 740 .
Kiely J, Kostusiak M, Bloom O, Roshan A ( 2019 ) . Poorly differentiated cutaneous squamous cell carcinomas have high incomplete excision rates with UK minimum recommended pre-determined surgical margins . Journal of Plastic Reconstructive & Aesthetic Surgery vol. 73 , ( 1 ) 43 - 52 .
Roshan A, Murai K, Fowler J, Simons BD, Nikolaidou-Neokosmidou V, Jones PH ( 2015 ) . Human keratinocytes have two interconvertible modes of proliferation . Nature Cell Biology vol. 18 , ( 2 ) 145 - 156 .
Martincorena I, Roshan A, Gerstung M, Ellis P, Van Loo P, McLaren S, Wedge DC, Fullam A et al. ( 2015 ) . High burden and pervasive positive selection of somatic mutations in normal human skin . Science vol. 348 , ( 6237 ) 880 - 886 .
Roshan A, Jones PH, Greenman CD ( 2014 ) . Exact, time-independent estimation of clone size distributions in normal and mutated cells . Journal of The Royal Society Interface vol. 11 , ( 99 )
Roshan A, Simons BD, Murai K, Jones PH ( 2014 ) . Abstract 145 . Plastic & Reconstructive Surgery vol. 133 , ( 3S ) 160 - 161 .
A R, PH J, CD G ( 2013 ) . An Exact, Time-Independent Approach to Clone Size Distributions in Normal and Mutated Cells .
Singh AK, Roshan A, Ram S ( 2013 ) . Outpatient taping in the treatment of idiopathic congenital talipes equinovarus . The Bone & Joint Journal vol. 95-B , ( 2 ) 271 - 278 .
Roshan A, Jones PH ( 2012 ) . Act your age: Tuning cell behavior to tissue requirements in interfollicular epidermis . Seminars in Cell and Developmental Biology vol. 23 , ( 8 ) 884 - 889 .
Roshan A, Jones PH ( 2012 ) . Chronic low dose UV exposure and p53 mutation: Tilting the odds in early epidermal preneoplasia? . International Journal of Radiation Biology vol. 88 , ( 10 ) 682 - 687 .
Doupé DP, Alcolea MP, Roshan A, Zhang G, Klein AM, Simons BD, Jones PH ( 2012 ) . A Single Progenitor Population Switches Behavior to Maintain and Repair Esophageal Epithelium . Science vol. 337 , ( 6098 ) 1091 - 1093 .
Roshan A, Grant I ( 2012 ) . Lessons for Adult Fingertip Regeneration: Glimpses From Basic Research . The Journal Of Hand Surgery vol. 37 , ( 6 ) 1287 - 1290 .
Shariff Z, Roshan A, Williams AM, Platt AJ ( 2010 ) . 2-Week wait referrals in suspected skin cancer: Does an instructional module for general practitioners improve diagnostic accuracy? . The Surgeon vol. 8 , ( 5 ) 247 - 251 .
Enoch S, Roshan A, Shah M ( 2009 ) . Emergency and early management of burns and scalds . The BMJ vol. 338 , ( apr08 1 )
Solanki NS, Roshan A, Malata CM ( 2009 ) . Pedicled gracilis myocutaneous flap for treatment of recalcitrant hidradenitis suppurativa of the groin and perineum . Journal of Wound Care vol. 18 , ( 3 ) 111 - 112 .
Roshan A, Agarwal S, England R ( 2008 ) . Role of information available over the internet: what are the parents of children undergoing tonsillectomy likely to find? . Annals of The Royal College of Surgeons of England vol. 90 , ( 7 ) 601 - 605 .
Roshan A, Kotwal A, Riaz M, Stanley PRW ( 2008 ) . Sternal wound dehiscence complicated by macromastia: report of two cases with discussion of literature . Journal of Plastic Reconstructive & Aesthetic Surgery vol. 62 , ( 10 ) e362 - e364 .
Roshan A, Ram S ( 2008 ) . The Neglected Femoral Neck Fracture in Young Adults: Review of a Challenging Problem . Clinical Medicine & Research vol. 6 , ( 1 ) 33 - 39 .
Roshan A, England J ( 2006 ) . Response to Mace and Stearns . Clinical Otolaryngology vol. 31 , ( 6 ) 556 - 557 .
Roshan A, Ram S ( 2006 ) . Early Return to Function in Young Adults with Neglected Femoral Neck Fractures . Clinical Orthopaedics and Related Research vol. 447 , ( &NA; ) 152 - 157 .
Roshan A, Kamath B, Roberts S, Atkin SL, England RJA ( 2006 ) . Intra‐operative parathyroid hormone monitoring in secondary hyperparathyroidism: is it useful? . Clinical Otolaryngology vol. 31 , ( 3 ) 198 - 203 .
Zhou Z, Cooper W, Lightowlers S, Coles C, Roshan A, Rosenfeld N, Cheng Z, Zhao H . A mathematical model of cell-free DNA fragment size reveals cancer-specific fragmentomic patterns .
Wang H, Mennea P, McAndrew G, Sonmezler O, Shcherbo D, Ditter E-J, Jensen S, Buma A et al. . A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole- genome sequencing . Science Advances
Else TR, Loreno C, Groves A, Cox BT, Gröhl J, Modolell I, Bohndiek SE, Roshan A . The confounding effects of skin colour in photoacoustic imaging .
Pacey S, Linossi C, Azizi A, Dayimu A, Machin A, Demiris N, Miremadi A, O'Donovan M et al. . Utility of ctDNA assessment after six weeks of immunotherapy to predict radiological response in advanced oesophageal cancer .