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Research
  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: MR Richard Milne

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Morling KL, ElGhazaly M, Milne RSB, Towers GJ ( 2025 ) . HIV capsids: orchestrators of innate immune evasion, pathogenesis and pandemicity . Journal of General Virology vol. 106 , ( 1 )
Walter J, Milne R, Towers GJ ( 2024 ) . Art and science: not as different as you think . The Biochemist vol. 46 , ( 3 ) 17 - 24 .
Khan H, Sumner RP, Rasaiyaah J, Tan CP, Rodriguez-Plata MT, Van Tulleken C, Fink D, Zuliani-Alvarez L et al. ( 2020 ) . HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF- κB/IRF3 nuclear transport . eLife vol. 9 ,
Ferreira CB, Sumner RP, Rodriguez-Plata MT, Rasaiyaah J, Milne RS, Thrasher AJ, Qasim W, Towers GJ ( 2019 ) . Lentiviral Vector Production Titer Is Not Limited in HEK293T by Induced Intracellular Innate Immunity . Molecular Therapy — Methods & Clinical Development vol. 17 , 209 - 219 .
Depledge DP, Cudini J, Kundu S, Atkinson C, Brown JR, Haque T, Houldcroft CJ, Koay ES et al. ( 2018 ) . High Viral Diversity and Mixed Infections in Cerebral Spinal Fluid From Cases of Varicella Zoster Virus Encephalitis . Journal of Infectious Diseases vol. 218 , ( 10 ) 1592 - 1601 .
Baraniak I, Kropff B, Ambrose L, McIntosh M, McLean GR, Pichon S, Atkinson C, Milne RSB et al. ( 2018 ) . Protection from cytomegalovirus viremia following glycoprotein B vaccination is not dependent on neutralizing antibodies . Proceedings of the National Academy of Sciences of the United States of America vol. 115 , ( 24 ) 6273 - 6278 .
Baraniak I, Kropff B, McLean GR, Pichon S, Piras-Douce F, Milne RSB, Smith C, Mach M et al. ( 2018 ) . Epitope-Specific Humoral Responses to Human Cytomegalovirus Glycoprotein-B Vaccine With MF59: Anti-AD2 Levels Correlate With Protection From Viremia . Journal of Infectious Diseases vol. 217 , ( 12 ) 1907 - 1917 .
Sumner RP, Thorne LG, Fink DL, Khan H, Milne RS, Towers GJ ( 2017 ) . Are Evolution and the Intracellular Innate Immune System Key Determinants in HIV Transmission? . Frontiers in Immunology vol. 8 ,
Lassalle F, Depledge DP, Reeves MB, Brown AC, Christiansen MT, Tutill HJ, Williams RJ, Einer-Jensen K et al. ( 2016 ) . Islands of linkage in an ocean of pervasive recombination reveals two-speed evolution of human cytomegalovirus genomes . Virus Evolution vol. 2 , ( 1 )
Blondeau C, Pelchen-Matthews A, Mlcochova P, Marsh M, Milne RSB, Towers GJ ( 2013 ) . Tetherin Restricts Herpes Simplex Virus 1 and Is Antagonized by Glycoprotein M . Journal of Virology vol. 87 , ( 24 ) 13124 - 13133 .
Marashi SM, Raeiszadeh M, Enright V, Tahami F, Workman S, Chee R, Webster AD, Milne RSB et al. ( 2012 ) . Influence of cytomegalovirus infection on immune cell phenotypes in patients with common variable immunodeficiency . The Journal of Allergy and Clinical Immunology vol. 129 , ( 5 ) 1349 - 1356.e3 .
Marashi SM, Raeiszadeh M, Workman S, Rahbar A, Soderberg-Naucler C, Klenerman P, Chee R, Webster AD et al. ( 2011 ) . Inflammation in common variable immunodeficiency is associated with a distinct CD8+ response to cytomegalovirus . The Journal of Allergy and Clinical Immunology vol. 127 , ( 6 ) 1385 - 1393.e4 .
Griffiths PD, Stanton A, McCarrell E, Smith C, Osman M, Harber M, Davenport A, Jones G et al. ( 2011 ) . Cytomegalovirus glycoprotein-B vaccine with MF59 adjuvant in transplant recipients: a phase 2 randomised placebo-controlled trial . The Lancet vol. 377 , ( 9773 ) 1256 - 1263 .
Lagos D, Pollara G, Henderson S, Gratrix F, Fabani M, Milne RSB, Gotch F, Boshoff C ( 2010 ) . miR-132 regulates antiviral innate immunity through suppression of the p300 transcriptional co-activator . Nature Cell Biology vol. 12 , ( 5 ) 513 - 519 .
Stiles KM, Milne RSB, Cohen GH, Eisenberg RJ, Krummenacher C ( 2008 ) . The herpes simplex virus receptor nectin-1 is down-regulated after trans-interaction with glycoprotein D . Virology vol. 373 , ( 1 ) 98 - 111 .
Whitbeck JC, Zuo Y, Milne RSB, Cohen GH, Eisenberg RJ ( 2006 ) . Stable Association of Herpes Simplex Virus with Target Membranes Is Triggered by Low pH in the Presence of the gD Receptor, HVEM . Journal of Virology vol. 80 , ( 8 ) 3773 - 3780 .
Milne RSB, Nicola AV, Whitbeck JC, Eisenberg RJ, Cohen GH ( 2005 ) . Glycoprotein D Receptor-Dependent, Low-pH-Independent Endocytic Entry of Herpes Simplex Virus Type 1 . Journal of Virology vol. 79 , ( 11 ) 6655 - 6663 .
Milne RSB, Hanna SL, Rux AH, Willis SH, Cohen GH, Eisenberg RJ ( 2003 ) . Function of Herpes Simplex Virus Type 1 gD Mutants with Different Receptor-Binding Affinities in Virus Entry and Fusion . Journal of Virology vol. 77 , ( 16 ) 8962 - 8972 .
Cairns TM, Milne RSB, Ponce-de-Leon M, Tobin DK, Cohen GH, Eisenberg RJ ( 2003 ) . Structure-Function Analysis of Herpes Simplex Virus Type 1 gD and gH-gL: Clues from gDgH Chimeras . Journal of Virology vol. 77 , ( 12 ) 6731 - 6742 .
Milne RSB, Connolly SA, Krummenacher C, Eisenberg RJ, Cohen GH ( 2001 ) . Porcine HveC, a Member of the Highly Conserved HveC/Nectin 1 Family, Is a Functional Alphaherpesvirus Receptor . Virology vol. 281 , ( 2 ) 315 - 328 .
Annett D, Morling KL, Critchley BJ, Graham B, Pingitore V, Whittaker TE, Kurdi N, Warne J et al. . A modified cyclosporine enhances lentivector transduction ex vivo and in vivo by degrading IFITM3 .
Khan H, Sumner RP, Rasaiyaah J, Tan CP, Rodriguez-Plata MT, van Tulleken C, Fink D, Zuliani-Alvarez L et al. . HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-κB/IRF3 nuclear transport .
Rookhuizen DC, Bonte P-E, Ye M, Hoyler T, Gentili M, Burgdorf N, Durand S, Aprahamian F et al. . Induction of transposable element expression is central to innate sensing .
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