Publications: PROF Clare Jolly

Mesner D, Whelan MVX, Shivkumar M, Reuschl A-K, Chiozzi RZ, Thalassinos K, de Bruin RAM, Jolly C ( 2026 ) . HIV-1 signalling remodels nuclear pores to licence infection . Nature1 - 11 .

Farrukee R, Mordant F, Mackenzie-Kludas C, Mesner D, Yamomoto M, Jolly C, Brooks AG, Subbarao K et al. ( 2025 ) . Human guanylate-binding protein (GBP) 1 inhibits replication of severe acute respiratory syndrome coronavirus 2 . Journal of Virology vol. 99 , ( 10 ) e00823 - e00825 .

Cheng MTK, Altaf M, Castin J, Reuschl A-K, Sievers BL, Kamelian K, Mesner D, Morse RB et al. ( 2025 ) . Signatures of omicron-like adaptation in early SARS-CoV-2 variants and chronic infection . Cell Reports vol. 44 , ( 8 )

Baiyegunhi OO, Mthembu K, Reuschl A-K, Ojwach D, Farinre O, Maimela M, Balinda S, Price M et al. ( 2025 ) . HIV-1 Gag-protease-driven replicative capacity influences T-cell metabolism, cytokine induction, and viral cell-to-cell spread . mBio vol. 16 , ( 4 ) e03565 - e03524 .

Newton LS, Gathmann C, Ridewood S, Smith RJ, Wijaya AJ, Hornsby TW, Morling KL, Annett D et al. ( 2025 ) . Macrocycle-based PROTACs selectively degrade cyclophilin A and inhibit HIV-1 and HCV . Nature Communications vol. 16 , ( 1 )

Reuschl A-K, Thorne LG, Whelan MVX, Ragazzini R, Furnon W, Cowton VM, De Lorenzo G, Mesner D et al. ( 2024 ) . Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants . Nature Microbiology vol. 9 , ( 2 ) 451 - 463 .

Bouhaddou M, Reuschl A-K, Polacco BJ, Thorne LG, Ummadi MR, Ye C, Rosales R, Pelin A et al. ( 2023 ) . SARS-CoV-2 variants evolve convergent strategies to remodel the host response . Cell vol. 186 , ( 21 ) 4597 - 4614.e26 .

Mesner D, Reuschl A-K, Whelan MVX, Bronzovich T, Haider T, Thorne LG, Ragazzini R, Bonfanti P et al. ( 2023 ) . SARS-CoV-2 evolution influences GBP and IFITM sensitivity . Proceedings of the National Academy of Sciences of the United States of America vol. 120 , ( 5 )

Reuschl A-K, Mesner D, Shivkumar M, Whelan MVX, Pallett LJ, Guerra-Assunção JA, Madansein R, Dullabh KJ et al. ( 2022 ) . HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells . Cell Reports vol. 39 , ( 2 )

Thorne LG, Bouhaddou M, Reuschl A-K, Zuliani-Alvarez L, Polacco B, Pelin A, Batra J, Whelan MVX et al. ( 2022 ) . Publisher Correction: Evolution of enhanced innate immune evasion by SARS-CoV-2 . Nature vol. 604 , ( 7905 ) e14 - e14 .

Howell R, Clarke MA, Reuschl A-K, Chen T, Abbott-Imboden S, Singer M, Lowe DM, Bennett CL et al. ( 2022 ) . Executable network of SARS-CoV-2-host interaction predicts drug combination treatments . npj Digital Medicine vol. 5 , ( 1 )

Snetkov X, Haider T, Mesner D, Groves N, van Engelenburg SB, Jolly C ( 2022 ) . A Conserved Tryptophan in the Envelope Cytoplasmic Tail Regulates HIV-1 Assembly and Spread . Viruses vol. 14 , ( 1 )

Varona JF, Landete P, Lopez-Martin JA, Estrada V, Paredes R, Guisado-Vasco P, de Orueta LF, Torralba M et al. ( 2022 ) . Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19 . Life Science Alliance vol. 5 , ( 4 )

Thorne LG, Bouhaddou M, Reuschl A-K, Zuliani-Alvarez L, Polacco B, Pelin A, Batra J, Whelan MVX et al. ( 2021 ) . Evolution of enhanced innate immune evasion by SARS-CoV-2 . Nature vol. 602 , ( 7897 ) 487 - 495 .

Yoshida M, Worlock KB, Huang N, Lindeboom RGH, Butler CR, Kumasaka N, Dominguez Conde C, Mamanova L et al. ( 2021 ) . Local and systemic responses to SARS-CoV-2 infection in children and adults . Nature vol. 602 , ( 7896 ) 321 - 327 .

Thorne LG, Reuschl A, Zuliani‐Alvarez L, Whelan MVX, Turner J, Noursadeghi M, Jolly C, Towers GJ ( 2021 ) . SARS‐CoV‐2 sensing by RIG‐I and MDA5 links epithelial infection to macrophage inflammation . The EMBO Journal vol. 40 , ( 15 )

Thorne LG, Bouhaddou M, Reuschl A-K, Zuliani-Alvarez L, Polacco B, Pelin A, Batra J, Whelan MVX et al. ( 2021 ) . Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant .

Haider T, Snetkov X, Jolly C ( 2021 ) . HIV envelope tail truncation confers resistance to SERINC5 restriction . Proceedings of the National Academy of Sciences of the United States of America vol. 118 , ( 21 )

Schmidt NM, Wing PAC, Diniz MO, Pallett LJ, Swadling L, Harris JM, Burton AR, Jeffery-Smith A et al. ( 2021 ) . Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint . Nature Communications vol. 12 , ( 1 )

Dicken SJ, Murray MJ, Thorne LG, Reuschl A-K, Forrest C, Ganeshalingham M, Muir L, Kalemera MD et al. ( 2021 ) . Characterisation of B.1.1.7 and Pangolin coronavirus spike provides insights on the evolutionary trajectory of SARS-CoV-2 .

Reuschl A-K, Thorne LG, Zuliani-Alvarez L, Bouhaddou M, Obernier K, Hiatt J, Soucheray M, Turner J et al. ( 2021 ) . Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant .

O’Nions J, Muir L, Zheng J, Rees-Spear C, Rosa A, Roustan C, Earl C, Cherepanov P et al. ( 2020 ) . SARS-CoV-2 antibody responses in patients with acute leukaemia . Leukemia vol. 35 , ( 1 ) 289 - 292 .

Mesner D, Hotter D, Kirchhoff F, Jolly C ( 2020 ) . Loss of Nef-mediated CD3 down-regulation in the HIV-1 lineage increases viral infectivity and spread . Proceedings of the National Academy of Sciences of the United States of America vol. 117 , ( 13 ) 7382 - 7391 .

Martin GE, Pace M, Thornhill JP, Phetsouphanh C, Meyerowitz J, Gossez M, Brown H, Olejniczak N et al. ( 2018 ) . CD32-Expressing CD4 T Cells Are Phenotypically Diverse and Can Contain Proviral HIV DNA . Frontiers in Immunology vol. 9 ,

Titanji BK, Pillay D, Jolly C ( 2017 ) . Combination antiretroviral therapy and cell–cell spread of wild-type and drug-resistant human immunodeficiency virus-1 . Journal of General Virology vol. 98 , ( 4 ) 821 - 834 .

Len ACL, Starling S, Shivkumar M, Jolly C ( 2017 ) . HIV-1 Activates T Cell Signaling Independently of Antigen to Drive Viral Spread . Cell Reports vol. 18 , ( 4 ) 1062 - 1074 .

Starling S, Jolly C ( 2016 ) . LFA-1 Engagement Triggers T Cell Polarization at the HIV-1 Virological Synapse . Journal of Virology vol. 90 , ( 21 ) 9841 - 9854 .

Zhang C, Zhou S, Groppelli E, Pellegrino P, Williams I, Borrow P, Chain BM, Jolly C ( 2015 ) . Hybrid Spreading Mechanisms and T Cell Activation Shape the Dynamics of HIV-1 Infection . PLOS Computational Biology vol. 11 , ( 4 )

Groppelli E, Len AC, Granger LA, Jolly C ( 2014 ) . Retromer Regulates HIV-1 Envelope Glycoprotein Trafficking and Incorporation into Virions . PLOS Pathogens vol. 10 , ( 11 )

Groppelli E, Starling S, Jolly C ( 2014 ) . Contact-Induced Mitochondrial Polarization Supports HIV-1 Virological Synapse Formation . Journal of Virology vol. 89 , ( 1 ) 14 - 24 .

McCoy LE, Groppelli E, Blanchetot C, de Haard H, Verrips T, Rutten L, Weiss RA, Jolly C ( 2014 ) . Neutralisation of HIV-1 cell-cell spread by human and llama antibodies . Retrovirology vol. 11 , ( 1 )

Titanji BK, Aasa-Chapman M, Pillay D, Jolly C ( 2013 ) . Protease inhibitors effectively block cell-to-cell spread of HIV-1 between T cells . Retrovirology vol. 10 , ( 1 )

Wei B, Han L, Abbink TEM, Groppelli E, Lim D, Thaker YR, Gao W, Zhai R et al. ( 2013 ) . Immune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptors . Retrovirology vol. 10 , ( 1 )

Groppelli E, Starling S, Jolly C ( 2013 ) . Contact-induced polarization shapes HIV-1 infected T cells for efficient HIV-1 dissemination at the virological synapse . Retrovirology vol. 10 , ( Suppl 1 ) P38 - P38 .

Jolly C, Welsch S, Michor S, Sattentau QJ ( 2011 ) . The regulated secretory pathway in CD4+T cells contributes to HIV-1 transmission at the virological synapse . Retrovirology vol. 8 , ( Suppl 2 )

Jolly C, Welsch S, Michor S, Sattentau QJ ( 2011 ) . The Regulated Secretory Pathway in CD4+ T cells Contributes to Human Immunodeficiency Virus Type-1 Cell-to-Cell Spread at the Virological Synapse . PLOS Pathogens vol. 7 , ( 9 )

Zhou L, Sokolskaja E, Jolly C, James W, Cowley SA, Fassati A ( 2011 ) . Transportin 3 Promotes a Nuclear Maturation Step Required for Efficient HIV-1 Integration . PLOS Pathogens vol. 7 , ( 8 )

Jolly C ( 2011 ) . Cell-to-cell transmission of retroviruses: Innate immunity and interferon-induced restriction factors . Virology vol. 411 , ( 2 ) 251 - 259 .

Jolly C, Booth NJ, Neil SJD ( 2010 ) . Cell-Cell Spread of Human Immunodeficiency Virus Type 1 Overcomes Tetherin/BST-2-Mediated Restriction in T cells . Journal of Virology vol. 84 , ( 23 ) 12185 - 12199 .

Jolly C ( 2010 ) . T Cell Polarization at the Virological Synapse . Viruses vol. 2 , ( 6 ) 1261 - 1278 .

Sowinski S, Alakoskela J-M, Jolly C, Davis DM ( 2010 ) . Optimized methods for imaging membrane nanotubes between T cells and trafficking of HIV-1 . Methods vol. 53 , ( 1 ) 27 - 33 .

González N, Bermejo M, Calonge E, Jolly C, Arenzana-Seisdedos F, Pablos JL, Sattentau QJ, Alcamí J ( 2010 ) . SDF-1/CXCL12 Production by Mature Dendritic Cells Inhibits the Propagation of X4-Tropic HIV-1 Isolates at the Dendritic Cell-T-Cell Infectious Synapse . Journal of Virology vol. 84 , ( 9 ) 4341 - 4351 .

Martin N, Welsch S, Jolly C, Briggs JAG, Vaux D, Sattentau QJ ( 2010 ) . Virological Synapse-Mediated Spread of Human Immunodeficiency Virus Type 1 between T Cells Is Sensitive to Entry Inhibition . Journal of Virology vol. 84 , ( 7 ) 3516 - 3527 .

Sowinski S, Jolly C, Berninghausen O, Purbhoo MA, Chauveau A, Köhler K, Oddos S, Eissmann P et al. ( 2008 ) . Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission . Nature Cell Biology vol. 10 , ( 2 ) 211 - 219 .

Jolly C, Sattentau QJ ( 2007 ) . Regulated secretion from CD4+ T cells . Trends in Immunology vol. 28 , ( 11 ) 474 - 481 .

Jolly C, Mitar I, Sattentau QJ ( 2007 ) . Adhesion Molecule Interactions Facilitate Human Immunodeficiency Virus Type 1-Induced Virological Synapse Formation between T Cells . Journal of Virology vol. 81 , ( 24 ) 13916 - 13921 .

Jolly C, Sattentau QJ ( 2007 ) . Human Immunodeficiency Virus Type 1 Assembly, Budding, and Cell-Cell Spread in T Cells Take Place in Tetraspanin-Enriched Plasma Membrane Domains . Journal of Virology vol. 81 , ( 15 ) 7873 - 7884 .

Jolly C, Mitar I, Sattentau QJ ( 2007 ) . Requirement for an Intact T-Cell Actin and Tubulin Cytoskeleton for Efficient Assembly and Spread of Human Immunodeficiency Virus Type 1 . Journal of Virology vol. 81 , ( 11 ) 5547 - 5560 .

Jolly CL, Sattentau QJ ( 2006 ) . Attachment Factors . Advances in Experimental Medicine and Biology vol. 790 , 1 - 23 .

Jolly C, Sattentau QJ ( 2005 ) . Human Immunodeficiency Virus Type 1 Virological Synapse Formation in T Cells Requires Lipid Raft Integrity . Journal of Virology vol. 79 , ( 18 ) 12088 - 12094 .

Jolly C, Sattentau QJ ( 2004 ) . Retroviral Spread by Induction of Virological Synapses . Traffic vol. 5 , ( 9 ) 643 - 650 .

Jolly C, Kashefi K, Hollinshead M, Sattentau QJ ( 2004 ) . HIV-1 Cell to Cell Transfer across an Env-induced, Actin-dependent Synapse . Journal of Experimental Medicine vol. 199 , ( 2 ) 283 - 293 .

Jolly CL, Huang J-A, Holmes IH ( 2001 ) . Selection of rotavirus VP4 cell receptor binding domains for MA104 cells using a phage display library . Journal of Virological Methods vol. 98 , ( 1 ) 41 - 51 .

Fazli A, Bradley SJ, Kiefel MJ, Jolly C, Holmes IH, von Itzstein M ( 2001 ) . Synthesis and Biological Evaluation of Sialylmimetics as Rotavirus Inhibitors . Journal of Medicinal Chemistry vol. 44 , ( 20 ) 3292 - 3301 .

Jolly CL, Beisner BM, Ozser E, Holmes IH ( 2001 ) . Non-lytic extraction and characterisation of receptors for multiple strains of rotavirus . Archives of Virology vol. 146 , ( 7 ) 1307 - 1323 .

Jolly CL, Beisner BM, Holmes IH ( 2000 ) . Rotavirus Infection of MA104 Cells Is Inhibited by Ricinus Lectin and Separately Expressed Single Binding Domains . Virology vol. 275 , ( 1 ) 89 - 97 .

Reuschl A-K, Thorne LG, Whelan MVX, Ragazzini R, Furnon W, Cowton VM, de Lorenzo G, Mesner D et al. . Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants .

Howell R, Clarke MA, Reuschl A-K, Chen T, Abbott-Imboden S, Singer M, Lowe DM, Bennett CL et al. . Executable Network of SARS-CoV-2-Host Interaction Predicts Drug Combination Treatments .

Bouhaddou M, Reuschl A-K, Polacco BJ, Thorne LG, Ummadi MR, Ye C, Rosales R, Pelin A et al. . Global landscape of the host response to SARS-CoV-2 variants reveals viral evolutionary trajectories .

Reuschl A-K, Shivkumar M, Mesner D, Pallett LJ, Guerra-Assunção JA, Madansein R, Sigal A, Herrera C . HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells .

O’Nions J, Muir L, Zheng J, Rees-Spear C, Rosa A, Earl C, Cherepanov P, Gupta R et al. . SARS-CoV-2 antibody responses in patients with aggressive haematological malignancies .

Thorne LG, Reuschl A-K, Zuliani-Alvarez L, Whelan MVX, Noursadeghi M, Jolly C, Towers GJ . SARS-CoV-2 sensing by RIG-I and MDA5 links epithelial infection to macrophage inflammation .

Cheng MTK, Altaf M, Castin J, Reuschl A-K, Sievers BL, Kamelian K, Mesner D, Morse RB et al. . Signatures of omicron-like adaptation in early SARS-CoV-2 variants and chronic infection .

Gathmann C, Newton LS, Ridewood S, Smith RJ, Hornsby TW, Reuschl A-K, Wijaya A, Morling KL et al. . Synthetic PROTACs based on a depsipeptide macrocycle selectively degrade cyclophilin A and inhibit HIV-1 .

Snetkov X, Haider T, Mesner D, Groves N, van Engelenburg S, Jolly C . The envelope cytoplasmic tail regulates HIV-1 assembly and spread .

Yoshida M, Worlock KB, Huang N, Lindeboom RGH, Butler CR, Kumasaka N, Conde CD, Mamanova L et al. . The local and systemic response to SARS-CoV-2 infection in children and adults .