Publications: PROF Paul Franks

Grieger JA, Takele WW, Vesco KK, Redman LM, Hannah W, Bonham MP, Chen M, Chivers SC et al. ( 2025 ) . Participant characteristics in the effectiveness of lifestyle interventions to optimize gestational weight gain: a systematic review and meta-analysis . Communications Medicine vol. 5 , ( 1 )

Cabre HE, Drews KL, Pomeroy J, Keadle SK, Arteaga SS, Franks PW, Haire-Joshu D, Knowler WC et al. ( 2025 ) . LIFE-Moms: effects of multicomponent lifestyle randomized control trial on physical activity during pregnancy in women with overweight and obesity . International Journal of Behavioral Nutrition and Physical Activity vol. 22 , ( 1 )

Singh T, Kalamajski S, Cunha JPMCM, Hladkou S, Roberts F, Gheibi S, Soltanian A, Farahmand KY et al. ( 2025 ) . Modeling Genetic Risk of β‐Cell Dysfunction in Human Induced Pluripotent Stem Cells From Patients Carrying the MTNR1B Risk Variant . Journal of Pineal Research vol. 77 , ( 5 )

Flanagan EW, Drews KL, Cade WT, Franks PW, Gallagher D, Phelan S, Van Horn L, Redman LM ( 2025 ) . Metabolic Health and Heterogenous Outcomes of Prenatal Interventions . JAMA Network Open vol. 8 , ( 8 )

Smit RAJ, Wade KH, Hui Q, Arias JD, Yin X, Christiansen MR, Yengo L, Preuss MH et al. ( 2025 ) . Polygenic prediction of body mass index and obesity through the life course and across ancestries . Nature Medicine vol. 31 , ( 9 ) 3151 - 3168 .

Connolly B, McCreight L, Slieker RC, Bedair KF, Donnelly L, de Klerk JA, Beulens JWJ, Elders PJM et al. ( 2025 ) . The influence of metformin treatment on the circulating proteome . EBioMedicine vol. 118 ,

Howey R, Adam J, Adamski J, Atabaki NN, Brunak S, Chmura PJ, De Masi F, Dermitzakis ET et al. ( 2025 ) . Bayesian network imputation methods applied to multi-omics data identify putative causal relationships in a type 2 diabetes dataset containing incomplete data: An IMI DIRECT Study . PLOS Genetics vol. 21 , ( 7 )

Lyu L, Fan Y, Vogt JK, Clos-Garcia M, Bonnefond A, Pedersen HK, Dutta A, Koivula R et al. ( 2025 ) . The dynamics of the gut microbiota in prediabetes during a four-year follow-up among European patients—an IMI-DIRECT prospective study . Genome Medicine vol. 17 , ( 1 )

Maguolo A, Jönsson J, Perfilyev A, Vaag A, Malchau Carlsen E, Nørgaard K, Franks PW, Renault KM et al. ( 2025 ) . Insulin levels at 18–20 gestational weeks in pregnant women with obesity are associated with newborn abdominal fat deposition and DNA methylation in cord blood . Clinical Epigenetics vol. 17 , ( 1 )

Guasch-Ferré M, Wittenbecher C, Palmnäs M, Ben-Yacov O, Blaak EE, Dahm CC, Fall T, Heitmann BL et al. ( 2025 ) . Precision nutrition for cardiometabolic diseases . Nature Medicine vol. 31 , ( 5 ) 1444 - 1453 .

Kämpe A, Gudmundsson S, Walsh CP, Lindblad-Toh K, Johansson Å, Clareborn A, Ameur A, Edsjö A et al. ( 2025 ) . Precision Omics Initiative Sweden (PROMISE) will integrate research with healthcare . Nature Medicine vol. 31 , ( 6 ) 1730 - 1732 .

Gallardo-Nuell L, Blanch J, Leal Y, Coral DE, Duarte-Salles T, Giordano GN, Franks PW, Pearson ER et al. ( 2025 ) . BMI-residualized data uncovers a cluster of people with type 2 diabetes and increased serum ferritin protected from cardiovascular disease . Cardiovascular Diabetology vol. 24 , ( 1 )

Fragoso-Bargas N, Mcbride NS, Lee-Ødegård S, Lawlor DA, Yousefi PD, Moen G-H, Opsahl JO, Jenum AK et al. ( 2025 ) . Correction: Epigenome-wide association study of objectively measured physical activity in peripheral blood leukocytes . BMC Genomics vol. 26 , ( 1 )

Fragoso-Bargas N, Mcbride NS, Lee-Ødegård S, Lawlor DA, Yousefi PD, Moen G-H, Opsahl JO, Jenum AK et al. ( 2025 ) . Epigenome-wide association study of objectively measured physical activity in peripheral blood leukocytes . BMC Genomics vol. 26 , ( 1 )

Maguolo A, Jönsson J, Perfilyev A, Maziarz M, Vaag A, Carlsen EM, Nørgaard K, Franks PW et al. ( 2024 ) . DNA methylation in cord blood partially mediates the effects of prepregnancy BMI on early childhood offspring BMI . Obesity vol. 33 , ( 1 ) 177 - 189 .

Birkenfeld AL, Franks PW, Mohan V ( 2024 ) . Precision Medicine in People at Risk for Diabetes and Atherosclerotic Cardiovascular Disease: A Fresh Perspective on Prevention . Circulation vol. 150 , ( 24 ) 1910 - 1912 .

Franks PW, Rich SS, Linder B, Zaghloul NA, Cefalu WT ( 2024 ) . A Research Roadmap to Address the Heterogeneity of Diabetes and Advance Precision Medicine . The Journal of Clinical Endocrinology & Metabolism vol. 110 , ( 3 ) 601 - 610 .

Coral DE, Smit F, Farzaneh A, Gieswinkel A, Tajes JF, Sparsø T, Delfin C, Bauvin P et al. ( 2024 ) . Author Correction: Subclassification of obesity for precision prediction of cardiometabolic diseases . Nature Medicine vol. 31 , ( 2 ) 695 - 695 .

Franks PW, Sargent JL ( 2024 ) . Diabetes and obesity: leveraging heterogeneity for precision medicine . European Heart Journal vol. 45 , ( 48 ) 5146 - 5155 .

Coral DE, Smit F, Farzaneh A, Gieswinkel A, Tajes JF, Sparsø T, Delfin C, Bauvin P et al. ( 2024 ) . Subclassification of obesity for precision prediction of cardiometabolic diseases . Nature Medicine vol. 31 , ( 2 ) 534 - 543 .

Sharma S, Dong Q, Haid M, Adam J, Bizzotto R, Fernandez-Tajes JJ, Jones AG, Tura A et al. ( 2024 ) . Role of human plasma metabolites in prediabetes and type 2 diabetes from the IMI-DIRECT study . Diabetologia vol. 67 , ( 12 ) 2804 - 2818 .

Franks PW, Coral DE ( 2024 ) . Causal drivers of human proteome variation in health and disease . Nature Metabolism vol. 6 , ( 10 ) 1854 - 1855 .

Lim SS, Semnani-Azad Z, Morieri ML, Ng AH, Ahmad A, Fitipaldi H, Boyle J, Collin C et al. ( 2024 ) . Reporting guidelines for precision medicine research of clinical relevance: the BePRECISE checklist . Nature Medicine vol. 30 , ( 7 ) 1874 - 1881 .

Naylor RN, Patel KA, Kettunen JLT, Männistö JME, Støy J, Beltrand J, Polak M, Vilsbøll T et al. ( 2024 ) . Precision treatment of beta-cell monogenic diabetes: a systematic review . Communications Medicine vol. 4 , ( 1 )

Cefalu WT, Franks PW, Rosenblum ND, Zaghloul NA, Florez JC, Giorgino F, Ji L, Ma RCW et al. ( 2024 ) . A global initiative to deliver precision health in diabetes . Nature Medicine vol. 30 , ( 7 ) 1819 - 1822 .

Mutie PM, Pomares-Millan H, Atabaki-Pasdar N, Coral D, Fitipaldi H, Tsereteli N, Tajes JF, Franks PW et al. ( 2024 ) . Correction: Investigating the causal relationships between excess adiposity and cardiometabolic health in men and women . Diabetologia vol. 67 , ( 9 ) 2015 - 2015 .

Stefanucci L, Moslemi C, Tomé AR, Virtue S, Bidault G, Gleadall NS, Watson LPE, Kwa JE et al. ( 2024 ) . SMIM1 absence is associated with reduced energy expenditure and excess weight . Med vol. 5 , ( 9 ) 1083 - 1095.e6 .

Franks PW, Estampador A ( 2024 ) . Obesity is Associated With Cardiovascular Disease in Adults. Is This True in Children? How Would I Diagnose Cardiovascular Complications in the Obese Child? . Curbside Consultation in Pediatric Obesity , Taylor & Francis

Chikowore T, Läll K, Micklesfield LK, Lombard Z, Goedecke JH, Fatumo S, Norris SA, Magi R et al. ( 2024 ) . Variability of polygenic prediction for body mass index in Africa . Genome Medicine vol. 16 , ( 1 )

Billings LK, Jablonski KA, Pan Q, Florez JC, Franks PW, Goldberg RB, Hivert M-F, Kahn SE et al. ( 2024 ) . Increased Genetic Risk for β-Cell Failure Is Associated With β-Cell Function Decline in People With Prediabetes . Diabetes vol. 73 , ( 8 ) 1352 - 1360 .

Eriksen R, White MC, Dawed AY, Perez IG, Posma JM, Haid M, Sharma S, Prehn C et al. ( 2024 ) . The Association of Cardiometabolic, Diet and Lifestyle Parameters With Plasma Glucagon-like Peptide-1: An IMI DIRECT Study . The Journal of Clinical Endocrinology & Metabolism vol. 109 , ( 9 ) e1697 - e1707 .

Takele WW, Vesco KK, Josefson J, Redman LM, Hannah W, Bonham MP, Chen M, Chivers SC et al. ( 2024 ) . Effective interventions in preventing gestational diabetes mellitus: A systematic review and meta-analysis . Communications Medicine vol. 4 , ( 1 )

Felton JL, Redondo MJ, Oram RA, Speake C, Long SA, Onengut-Gumuscu S, Rich SS, Monaco GSF et al. ( 2024 ) . Islet autoantibodies as precision diagnostic tools to characterize heterogeneity in type 1 diabetes: a systematic review . Communications Medicine vol. 4 , ( 1 )

Semple RK, Patel KA, Auh S, Brown RJ ( 2024 ) . Author Correction: Genotype-stratified treatment for monogenic insulin resistance: a systematic review . Communications Medicine vol. 4 , ( 1 )

Franks PW ( 2024 ) . Look AHEAD to Precision Prevention in Type 2 Diabetes . The Journal of Clinical Endocrinology & Metabolism vol. 109 , ( 10 ) e1944 - e1945 .

Delfin C, Dragan I, Kuznetsov D, Tajes JF, Smit F, Coral DE, Farzaneh A, Haugg A et al. ( 2024 ) . A Federated Database for Obesity Research: An IMI-SOPHIA Study . Life vol. 14 , ( 2 )

Ahmad A, Lim L-L, Morieri ML, Tam CH-T, Cheng F, Chikowore T, Dudenhöffer-Pfeifer M, Fitipaldi H et al. ( 2024 ) . Precision prognostics for cardiovascular disease in Type 2 diabetes: a systematic review and meta-analysis . Communications Medicine vol. 4 , ( 1 )

Semnani-Azad Z, Gaillard R, Hughes AE, Boyle KE, Tobias DK, Perng W ( 2024 ) . Precision stratification of prognostic risk factors associated with outcomes in gestational diabetes mellitus: a systematic review . Communications Medicine vol. 4 , ( 1 )

Huang M, Prasad RB, Coral DE, Hjort L, Minja DTR, Mulder H, Franks PW, Kalamajski S ( 2024 ) . Human Genetic Variation at rs10071329 Correlates With Adiposity-Related Traits, Modulates PPARGC1B Expression, and Alters Brown Adipocyte Function . Diabetes vol. 73 , ( 4 ) 637 - 645 .

Francis EC, Powe CE, Lowe WL, White SL, Scholtens DM, Yang J, Zhu Y, Zhang C et al. ( 2023 ) . Refining the diagnosis of gestational diabetes mellitus: a systematic review and meta-analysis . Communications Medicine vol. 3 , ( 1 )

Li JH, Perry JA, Jablonski KA, Srinivasan S, Chen L, Todd JN, Harden M, Mercader JM et al. ( 2023 ) . Identification of Genetic Variation Influencing Metformin Response in a Multiancestry Genome-Wide Association Study in the Diabetes Prevention Program (DPP) . Diabetes vol. 72 , ( 8 ) 1161 - 1172 .

de las Fuentes L, Schwander KL, Brown MR, Bentley AR, Winkler TW, Sung YJ, Munroe PB, Miller CL et al. ( 2023 ) . Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci . Frontiers in Genetics vol. 14 ,

Bermingham KM, Smith HA, Gonzalez JT, Duncan EL, Valdes AM, Franks PW, Delahanty L, Dashti HS et al. ( 2023 ) . Glycaemic variability, assessed with continuous glucose monitors, is associated with diet, lifestyle and health in people without diabetes . rs.3.rs - 3469475 .

Willems SM, Ng NHJ, Fernandez J, Fine RS, Wheeler E, Wessel J, Kitajima H, Marenne G et al. ( 2023 ) . Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization . Wellcome Open Research vol. 8 ,

Felton JL, Griffin KJ, Oram RA, Speake C, Long SA, Onengut-Gumuscu S, Rich SS, Monaco GSF et al. ( 2023 ) . Disease-modifying therapies and features linked to treatment response in type 1 diabetes prevention: a systematic review . Communications Medicine vol. 3 , ( 1 )

Semple RK, Patel KA, Auh S, Brown RJ ( 2023 ) . Genotype-stratified treatment for monogenic insulin resistance: a systematic review . Communications Medicine vol. 3 , ( 1 )

Bodhini D, Morton RW, Santhakumar V, Nakabuye M, Pomares-Millan H, Clemmensen C, Fitzpatrick SL, Guasch-Ferre M et al. ( 2023 ) . Impact of individual and environmental factors on dietary or lifestyle interventions to prevent type 2 diabetes development: a systematic review . Communications Medicine vol. 3 , ( 1 )

Lim S, Takele WW, Vesco KK, Redman LM, Hannah W, Bonham MP, Chen M, Chivers SC et al. ( 2023 ) . Participant characteristics in the prevention of gestational diabetes as evidence for precision medicine: a systematic review and meta-analysis . Communications Medicine vol. 3 , ( 1 )

Benham JL, Gingras V, McLennan N-M, Most J, Yamamoto JM, Aiken CE, Ozanne SE, Reynolds RM ( 2023 ) . Precision gestational diabetes treatment: a systematic review and meta-analyses . Communications Medicine vol. 3 , ( 1 )

Misra S, Wagner R, Ozkan B, Schön M, Sevilla-Gonzalez M, Prystupa K, Wang CC, Kreienkamp RJ et al. ( 2023 ) . Precision subclassification of type 2 diabetes: a systematic review . Communications Medicine vol. 3 , ( 1 )

Tobias DK, Merino J, Ahmad A, Aiken C, Benham JL, Bodhini D, Clark AL, Colclough K et al. ( 2023 ) . Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine . Nature Medicine vol. 29 , ( 10 ) 2438 - 2457 .

Murphy R, Colclough K, Pollin TI, Ikle JM, Svalastoga P, Maloney KA, Saint-Martin C, Molnes J et al. ( 2023 ) . The use of precision diagnostics for monogenic diabetes: a systematic review and expert opinion . Communications Medicine vol. 3 , ( 1 )

Young KG, McInnes EH, Massey RJ, Kahkoska AR, Pilla SJ, Raghavan S, Stanislawski MA, Tobias DK et al. ( 2023 ) . Treatment effect heterogeneity following type 2 diabetes treatment with GLP1-receptor agonists and SGLT2-inhibitors: a systematic review . Communications Medicine vol. 3 , ( 1 )

Jacobsen LM, Sherr JL, Considine E, Chen A, Peeling SM, Hulsmans M, Charleer S, Urazbayeva M et al. ( 2023 ) . Utility and precision evidence of technology in the treatment of type 1 diabetes: a systematic review . Communications Medicine vol. 3 , ( 1 )

Franks PW, Cefalu WT, Dennis J, Florez JC, Mathieu C, Morton RW, Ridderstråle M, Sillesen HH et al. ( 2023 ) . Precision medicine for cardiometabolic disease: a framework for clinical translation . The Lancet Diabetes & Endocrinology vol. 11 , ( 11 ) 822 - 835 .

Misra S, Aguilar-Salinas CA, Chikowore T, Konradsen F, Ma RCW, Mbau L, Mohan V, Morton RW et al. ( 2023 ) . The case for precision medicine in the prevention, diagnosis, and treatment of cardiometabolic diseases in low-income and middle-income countries . The Lancet Diabetes & Endocrinology vol. 11 , ( 11 ) 836 - 847 .

Leslie RD, Ma RCW, Franks PW, Nadeau KJ, Pearson ER, Redondo MJ ( 2023 ) . Understanding diabetes heterogeneity: key steps towards precision medicine in diabetes . The Lancet Diabetes & Endocrinology vol. 11 , ( 11 ) 848 - 860 .

Bermingham KM, May A, Asnicar F, Capdevila J, Leeming ER, Franks PW, Valdes AM, Wolf J et al. ( 2023 ) . Snack quality and snack timing are associated with cardiometabolic blood markers: the ZOE PREDICT study . European Journal of Nutrition vol. 63 , ( 1 ) 121 - 133 .

Nogal A, Tettamanzi F, Dong Q, Louca P, Visconti A, Christiansen C, Breuninger T, Linseisen J et al. ( 2023 ) . A Fecal Metabolite Signature of Impaired Fasting Glucose: Results From Two Independent Population-Based Cohorts . Diabetes vol. 72 , ( 12 ) 1870 - 1880 .

van der Meer R, Mohamed SA, Monpellier VM, Liem RSL, Hazebroek EJ, Franks PW, Frayling TM, Janssen IMC et al. ( 2023 ) . Genetic variants associated with weight loss and metabolic outcomes after bariatric surgery: A systematic review . Obesity Reviews vol. 24 , ( 12 )

Brown AA, Fernandez-Tajes JJ, Hong M-G, Brorsson CA, Koivula RW, Davtian D, Dupuis T, Sartori A et al. ( 2023 ) . Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits . Nature Communications vol. 14 , ( 1 )

Bermingham KM, Stensrud S, Asnicar F, Valdes AM, Franks PW, Wolf J, Hadjigeorgiou G, Davies R et al. ( 2023 ) . Exploring the relationship between social jetlag with gut microbial composition, diet and cardiometabolic health, in the ZOE PREDICT 1 cohort . European Journal of Nutrition vol. 62 , ( 8 ) 3135 - 3147 .

Nogal A, Asnicar F, Vijay A, Kouraki A, Visconti A, Louca P, Wong K, Baleanu A-F et al. ( 2023 ) . Genetic and gut microbiome determinants of SCFA circulating and fecal levels, postprandial responses and links to chronic and acute inflammation . Gut Microbes vol. 15 , ( 1 )

Louca P, Štambuk T, Frkatović-Hodžić A, Nogal A, Mangino M, Berry SE, Deriš H, Hadjigeorgiou G et al. ( 2023 ) . Plasma protein N-glycome composition associates with postprandial lipaemic response . BMC Medicine vol. 21 , ( 1 )

Lampousi A-M, Carlsson S, Löfvenborg JE, Cabrera-Castro N, Chirlaque M-D, Fagherazzi G, Franks PW, Hampe CS et al. ( 2023 ) . Interaction between plasma phospholipid odd-chain fatty acids and GAD65 autoantibodies on the incidence of adult-onset diabetes: the EPIC-InterAct case–cohort study . Diabetologia vol. 66 , ( 8 ) 1460 - 1471 .

Bermingham KM, Mazidi M, Franks PW, Maher T, Valdes AM, Linenberg I, Wolf J, Hadjigeorgiou G et al. ( 2023 ) . Characterisation of Fasting and Postprandial NMR Metabolites: Insights from the ZOE PREDICT 1 Study . Nutrients vol. 15 , ( 11 )

Graham SE, Clarke SL, Wu K-HH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I et al. ( 2023 ) . Author Correction: The power of genetic diversity in genome-wide association studies of lipids . Nature vol. 618 , ( 7965 ) e19 - e20 .

Li JH, Brenner LN, Kaur V, Figueroa K, Schroeder P, Huerta-Chagoya A, Udler MS, Leong A et al. ( 2023 ) . Genome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH . Diabetologia vol. 66 , ( 7 ) 1260 - 1272 .

Huang M, Claussnitzer M, Saadat A, Coral DE, Kalamajski S, Franks PW ( 2023 ) . Engineered allele substitution at PPARGC1A rs8192678 alters human white adipocyte differentiation, lipogenesis, and PGC-1α content and turnover . Diabetologia vol. 66 , ( 7 ) 1289 - 1305 .

Slieker RC, Donnelly LA, Akalestou E, Lopez-Noriega L, Melhem R, Güneş A, Abou Azar F, Efanov A et al. ( 2023 ) . Identification of biomarkers for glycaemic deterioration in type 2 diabetes . Nature Communications vol. 14 , ( 1 )

Allesøe RL, Lundgaard AT, Hernández Medina R, Aguayo-Orozco A, Johansen J, Nissen JN, Brorsson C, Mazzoni G et al. ( 2023 ) . Author Correction: Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models . Nature Biotechnology vol. 41 , ( 7 ) 1026 - 1026 .

Sobiecki JG, Imamura F, Davis CR, Sharp SJ, Koulman A, Hodgson JM, Guevara M, Schulze MB et al. ( 2023 ) . A nutritional biomarker score of the Mediterranean diet and incident type 2 diabetes: Integrated analysis of data from the MedLey randomised controlled trial and the EPIC-InterAct case-cohort study . PLOS Medicine vol. 20 , ( 4 )

Franks PW ( 2023 ) . Socioeconomic Disparities Across the Spectrum of Genetic Burden in Type 2 Diabetes and Obesity Risk . Diabetes Care vol. 46 , ( 5 ) 916 - 917 .

Johansson Å, Andreassen OA, Brunak S, Franks PW, Hedman H, Loos RJF, Meder B, Melén E et al. ( 2023 ) . Precision medicine in complex diseases—Molecular subgrouping for improved prediction and treatment stratification . Journal of Internal Medicine vol. 294 , ( 4 ) 378 - 396 .

Louca P, Meijnikman AS, Nogal A, Asnicar F, Attaye I, Vijay A, Kouraki A, Visconti A et al. ( 2023 ) . The secondary bile acid isoursodeoxycholate correlates with post-prandial lipemia, inflammation, and appetite and changes post-bariatric surgery . Cell Reports Medicine vol. 4 , ( 4 )

Freidin MB, Cheetham N, Duncan EL, Steves CJ, Doores KJ, Malim MH, Rossi N, Lord JM et al. ( 2023 ) . Long-COVID fatigue is not predicted by pre-pandemic plasma IL-6 levels in mild COVID-19 . Inflammation Research vol. 72 , ( 5 ) 947 - 953 .

Jönsson J, Renault KM, Perfilyev A, Vaag A, Carlsen EM, Nørgaard K, Franks PW, Ling C ( 2023 ) . Gestational weight gain in pregnant women with obesity is associated with cord blood DNA methylation, which partially mediates offspring anthropometrics . Clinical and Translational Medicine vol. 13 , ( 3 )

Huang M, Coral D, Ardalani H, Spegel P, Saadat A, Claussnitzer M, Mulder H, Franks PW et al. ( 2023 ) . Identification of a weight loss-associated causal eQTL in MTIF3 and the effects of MTIF3 deficiency on human adipocyte function . eLife vol. 12 ,

Coral DE, Franks PW ( 2023 ) . Proteogenomic mapping sets stage for precision medicine . Nature Metabolism vol. 5 , ( 3 ) 366 - 367 .

Domalpally A, Whittier SA, Pan Q, Dabelea DM, Darwin CH, Knowler WC, Lee CG, Luchsinger JA et al. ( 2023 ) . Association of Metformin With the Development of Age-Related Macular Degeneration . JAMA Ophthalmology vol. 141 , ( 2 ) 140 - 147 .

Coral DE, Fernandez-Tajes J, Tsereteli N, Pomares-Millan H, Fitipaldi H, Mutie PM, Atabaki-Pasdar N, Kalamajski S et al. ( 2023 ) . A phenome-wide comparative analysis of genetic discordance between obesity and type 2 diabetes . Nature Metabolism vol. 5 , ( 2 ) 237 - 247 .

Allesøe RL, Lundgaard AT, Hernández Medina R, Aguayo-Orozco A, Johansen J, Nissen JN, Brorsson C, Mazzoni G et al. ( 2023 ) . Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models . Nature Biotechnology vol. 41 , ( 3 ) 399 - 408 .

Dawed AY, Mari A, Brown A, McDonald TJ, Li L, Wang S, Hong M-G, Sharma S et al. ( 2023 ) . Pharmacogenomics of GLP-1 receptor agonists: a genome-wide analysis of observational data and large randomised controlled trials . The Lancet Diabetes & Endocrinology vol. 11 , ( 1 ) 33 - 41 .

Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke SL, Bhatti KF et al. ( 2022 ) . Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis . Genome Biology vol. 23 , ( 1 )

Lee BY, Ordovás JM, Parks EJ, Anderson CAM, Barabási A-L, Clinton SK, de la Haye K, Duffy VB et al. ( 2022 ) . Research gaps and opportunities in precision nutrition: an NIH workshop report . American Journal of Clinical Nutrition vol. 116 , ( 6 ) 1877 - 1900 .

Vallat R, Berry SE, Tsereteli N, Capdevila J, Khatib HA, Valdes AM, Delahanty LM, Drew DA et al. ( 2022 ) . How people wake up is associated with previous night’s sleep together with physical activity and food intake . Nature Communications vol. 13 , ( 1 )

Louca P, Berry SE, Bermingham K, Franks PW, Wolf J, Spector TD, Valdes AM, Chowienczyk P et al. ( 2022 ) . Postprandial Responses to a Standardised Meal in Hypertension: The Mediatory Role of Visceral Fat Mass . Nutrients vol. 14 , ( 21 )

Bermingham KM, Linenberg I, Hall WL, Kadé K, Franks PW, Davies R, Wolf J, Hadjigeorgiou G et al. ( 2022 ) . Menopause is associated with postprandial metabolism, metabolic health and lifestyle: The ZOE PREDICT study . EBioMedicine vol. 85 ,

Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen AU et al. ( 2022 ) . A saturated map of common genetic variants associated with human height . Nature vol. 610 , ( 7933 ) 704 - 712 .

Mutie PM, Pomares-Millan H, Atabaki-Pasdar N, Coral D, Fitipaldi H, Tsereteli N, Tajes JF, Franks PW et al. ( 2022 ) . Investigating the causal relationships between excess adiposity and cardiometabolic health in men and women . Diabetologia vol. 66 , ( 2 ) 321 - 335 .

Fitipaldi H, Franks PW ( 2022 ) . Ethnic, gender and other sociodemographic biases in genome-wide association studies for the most burdensome non-communicable diseases: 2005–2022 . Human Molecular Genetics vol. 32 , ( 3 ) 520 - 532 .

Shams-White MM, Tjaden AH, Edelstein SL, Bassiouni S, Kahle LL, Kim C, Pi-Sunyer X, Temple KA et al. ( 2022 ) . The 2018 World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) score and diabetes risk in the Diabetes Prevention Program Outcomes Study (DPPOS) . BMC Nutrition vol. 8 , ( 1 )

P W, SE B, G F, R O, G H, DA D, HA K, LH N et al. ( 2022 ) . Postprandial glycaemic dips predict appetite and energy intake in healthy individuals .

Freidin M, Cheetham N, Duncan E, Steves C, Doores K, Malim MH, Rossi N, Lord J et al. ( 2022 ) . Pre-Pandemic Plasma IL-6 Levels are Positively Associated with Chronic Fatigue But Do Not Differentiate Those with COVID-19 Induced Fatigue .

Bonander C, Stranges D, Gustavsson J, Almgren M, Inghammar M, Moghaddassi M, Nilsson A, Pujol JC et al. ( 2022 ) . A regression discontinuity analysis of the social distancing recommendations for older adults in Sweden during COVID-19 . European Journal of Public Health vol. 32 , ( 5 ) 799 - 806 .

Ramdas S, Judd J, Graham SE, Kanoni S, Wang Y, Surakka I, Wenz B, Clarke SL et al. ( 2022 ) . A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids . American Journal of Human Genetics vol. 109 , ( 8 ) 1366 - 1387 .

Pomares-Millan H, Poveda A, Atabaki-Pasdar N, Johansson I, Björk J, Ohlsson M, Giordano GN, Franks PW ( 2022 ) . Predicting Sensitivity to Adverse Lifestyle Risk Factors for Cardiometabolic Morbidity and Mortality . Nutrients vol. 14 , ( 15 )

Bermingham K, Linenberg I, Valdes A, Hall W, Manson J, Newson L, Chan A, Kade K et al. ( 2022 ) . Menopause Is a Key Factor Influencing Postprandial Metabolism, Metabolic Health and Lifestyle: The ZOE PREDICT Study . Current Developments in Nutrition vol. 6 , ( Suppl 1 )

Berry S, Bermingham K, Valdes A, Franks P, Wolf J, Spector T ( 2022 ) . Optimised Glucose “Time in Range” Using Continuous Glucose Monitors in 4,805 Non-Diabetic Individuals Is Associated With Favourable Diet and Health: The ZOE PREDICT Studies . Current Developments in Nutrition vol. 6 , ( Suppl 1 )

Linenberg I, Bermingham K, Mazidi M, Valdes A, Franks P, Chan A, Wolf J, Spector T et al. ( 2022 ) . Postprandial and Fasting Metabolic Signatures: Insights From the ZOE PREDICT 1 Study . Current Developments in Nutrition vol. 6 , ( Suppl 1 )

Bermingham K, Stensrud S, Valdes A, Franks P, Chan A, Wolf J, Spector T, Berry S et al. ( 2022 ) . Social Jetlag Is Associated With Poor Diet and Increased Inflammation in the ZOE PREDICT 1 Cohort . Current Developments in Nutrition vol. 6 , ( Suppl 1 )

Klemp I, Hoffmann A, Müller L, Hagemann T, Horn K, Rohde‐Zimmermann K, Tönjes A, Thiery J et al. ( 2022 ) . DNA methylation patterns reflect individual's lifestyle independent of obesity . Clinical and Translational Medicine vol. 12 , ( 6 )

Merino J, Guasch-Ferré M, Li J, Chung W, Hu Y, Ma B, Li Y, Kang JH et al. ( 2022 ) . Polygenic scores, diet quality, and type 2 diabetes risk: An observational study among 35,759 adults from 3 US cohorts . PLOS Medicine vol. 19 , ( 4 )

Kennedy B, Fitipaldi H, Hammar U, Maziarz M, Tsereteli N, Oskolkov N, Varotsis G, Franks CA et al. ( 2022 ) . App-based COVID-19 syndromic surveillance and prediction of hospital admissions in COVID Symptom Study Sweden . Nature Communications vol. 13 , ( 1 )

Molteni E, Astley CM, Ma W, Sudre CH, Magee LA, Murray B, Fall T, Gomez MF et al. ( 2022 ) . Author Correction: Symptoms and syndromes associated with SARS-CoV-2 infection and severity in pregnant women from two community cohorts . Scientific Reports vol. 12 , ( 1 )

Maxwell TJ, Franks PW, Kahn SE, Knowler WC, Mather KJ, Florez JC, Jablonski KA ( 2022 ) . Correction to: Quantitative trait loci, G×E and G×G for glycemic traits: response to metformin and placebo in the Diabetes Prevention Program (DPP) . Journal of Human Genetics vol. 67 , ( 8 ) 503 - 503 .

Nguyen LH, Joshi AD, Drew DA, Merino J, Ma W, Lo C-H, Kwon S, Wang K et al. ( 2022 ) . Author Correction: Self-reported COVID-19 vaccine hesitancy and uptake among participants from different racial and ethnic groups in the United States and United Kingdom . Nature Communications vol. 13 , ( 1 )

Pomares-Millan H, Atabaki-Pasdar N, Coral D, Johansson I, Giordano GN, Franks PW ( 2022 ) . Estimating the Direct Effect between Dietary Macronutrients and Cardiometabolic Disease, Accounting for Mediation by Adiposity and Physical Activity . Nutrients vol. 14 , ( 6 )

Maxwell TJ, Franks PW, Kahn SE, Knowler WC, Mather KJ, Florez JC, Jablonski KA ( 2022 ) . Quantitative trait loci, G×E and G×G for glycemic traits: response to metformin and placebo in the Diabetes Prevention Program (DPP) . Journal of Human Genetics vol. 67 , ( 8 ) 465 - 473 .

Poveda A, Pomares-Millan H, Chen Y, Kurbasic A, Patel CJ, Renström F, Hallmans G, Johansson I et al. ( 2022 ) . Exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits . Scientific Reports vol. 12 , ( 1 )

Mohamed SA, Fernadez-Tajes J, Franks PW, Bennet L ( 2022 ) . GWAS in people of Middle Eastern descent reveals a locus protective of kidney function—a cross-sectional study . BMC Medicine vol. 20 , ( 1 )

Pervjakova N, Moen G-H, Borges M-C, Ferreira T, Cook JP, Allard C, Beaumont RN, Canouil M et al. ( 2022 ) . Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes . Human Molecular Genetics vol. 31 , ( 19 ) 3377 - 3391 .

Nogal A, Louca P, Tran TQB, Bowyer RC, Christofidou P, Steves CJ, Berry SE, Wong K et al. ( 2022 ) . Incremental Value of a Panel of Serum Metabolites for Predicting Risk of Atherosclerotic Cardiovascular Disease . Journal of the American Heart Association vol. 11 , ( 4 )

Bermingham K, Valdes A, Franks P, Wolf J, Spector T, Berry S ( 2022 ) . Measures of optimal glucose “time in range” and variability using continuous glucose monitors in 4,805 healthy non-diabetic individuals is discriminatory of cardiovascular health risk . Proceedings of The Nutrition Society vol. 81 , ( OCE1 )

Bermingham K, Valdes A, Hall W, Linenberg I, Franks P, Wolf J, Spector T, Berry S ( 2022 ) . Menopause and postprandial metabolic and inflammatory responses: a cross-sectional study exploring associations with sleep, physical activity and habitual diet . Proceedings of The Nutrition Society vol. 81 , ( OCE1 )

Merino J, Linenberg I, Bermingham KM, Ganesh S, Bakker E, Delahanty LM, Chan AT, Pujol JC et al. ( 2022 ) . Validity of continuous glucose monitoring for categorizing glycemic responses to diet: implications for use in personalized nutrition . American Journal of Clinical Nutrition vol. 115 , ( 6 ) 1569 - 1576 .

Nguyen LH, Joshi AD, Drew DA, Merino J, Ma W, Lo C-H, Kwon S, Wang K et al. ( 2022 ) . Self-reported COVID-19 vaccine hesitancy and uptake among participants from different racial and ethnic groups in the United States and United Kingdom . Nature Communications vol. 13 , ( 1 )

McCaffery JM, Jablonski KA, Pan Q, Astrup A, Revsbech Christiansen M, Corella D, Corso LML, Florez JC et al. ( 2022 ) . Genetic Predictors of Change in Waist Circumference and Waist-to-Hip Ratio With Lifestyle Intervention: The Trans-NIH Consortium for Genetics of Weight Loss Response to Lifestyle Intervention . Diabetes vol. 71 , ( 4 ) 669 - 676 .

Nolan JJ, Kahkoska AR, Semnani-Azad Z, Hivert M-F, Ji L, Mohan V, Eckel RH, Philipson LH et al. ( 2022 ) . ADA/EASD Precision Medicine in Diabetes Initiative: An International Perspective and Future Vision for Precision Medicine in Diabetes . Diabetes Care vol. 45 , ( 2 ) 261 - 266 .

Wesolowska-Andersen A, Brorsson CA, Bizzotto R, Mari A, Tura A, Koivula R, Mahajan A, Vinuela A et al. ( 2022 ) . Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study . Cell Reports Medicine vol. 3 , ( 1 )

Bermingham K, Linenberg I, Hall WL, Kadé K, Franks P, Davies R, Hadjigeorgiou G, Wolf J et al. ( 2022 ) . Menopause Is Associated With Postprandial Metabolism, Metabolic Health and Lifestyle: The ZOE PREDICT Study .

Pomares-Millan H, Poveda A, Atabaki-Pasdar N, Johansson I, Björk J, Ohlsson M, GIORDANO GN, Franks P ( 2022 ) . Predicting Sensitivity to Adverse Lifestyle Risk Factors for Cardiometabolic Morbidity and Mortality .

Mazidi M, Leeming ER, Merino J, Nguyen LH, Selvachandran S, Pujal JC, Maher T, Kadé K et al. ( 2021 ) . Diet and lifestyle behaviour disruption related to the pandemic was varied and bidirectional among US and UK adults participating in the ZOE COVID Study . Nature Food vol. 2 , ( 12 ) 957 - 969 .

Behravesh M, Fernandez-Tajes J, Estampador AC, Varga TV, Gunnarsson ÓS, Strevens H, Timpka S, Franks PW ( 2021 ) . A prospective study of the relationships between movement and glycemic control during day and night in pregnancy . Scientific Reports vol. 11 , ( 1 )

Graham SE, Clarke SL, Wu K-HH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I et al. ( 2021 ) . The power of genetic diversity in genome-wide association studies of lipids . Nature vol. 600 , ( 7890 ) 675 - 679 .

Tsereteli N, Vallat R, Fernandez-Tajes J, Delahanty LM, Ordovas JM, Drew DA, Valdes AM, Segata N et al. ( 2021 ) . Impact of insufficient sleep on dysregulated blood glucose control under standardised meal conditions . Diabetologia vol. 65 , ( 2 ) 356 - 365 .

Murray B, Kerfoot E, Chen L, Deng J, Graham MS, Sudre CH, Molteni E, Canas LS et al. ( 2021 ) . Accessible data curation and analytics for international-scale citizen science datasets . Scientific Data vol. 8 , ( 1 )

Wu C, Borné Y, Gao R, López Rodriguez M, Roell WC, Wilson JM, Regmi A, Luan C et al. ( 2021 ) . Elevated circulating follistatin associates with an increased risk of type 2 diabetes . Nature Communications vol. 12 , ( 1 )

J J, KM R, S G-C, A P, AC E, K N, M VL, A V et al. ( 2021 ) . Lifestyle intervention in pregnant women with obesity impacts cord blood DNA methylation, which associates with body composition in the offspring .

Kalamajski S, Huang M, Dalla-Riva J, Keller M, Dawed AY, Hansson O, Pearson ER, Consortium MP et al. ( 2021 ) . Genomic editing of metformin efficacy-associated genetic variants in SLC47A1 does not alter SLC47A1 expression . Human Molecular Genetics vol. 31 , ( 4 ) 491 - 498 .

Merino J, Joshi AD, Nguyen LH, Leeming ER, Mazidi M, Drew DA, Gibson R, Graham MS et al. ( 2021 ) . Diet quality and risk and severity of COVID-19: a prospective cohort study . Gut vol. 70 , ( 11 ) 2096 - 2104 .

Slieker RC, Donnelly LA, Fitipaldi H, Bouland GA, Giordano GN, Åkerlund M, Gerl MJ, Ahlqvist E et al. ( 2021 ) . Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study . Diabetes vol. 70 , ( 11 ) 2683 - 2693 .

Wyatt P, Berry SE, Finlayson G, O’Driscoll R, Hadjigeorgiou G, Drew DA, Khatib HA, Nguyen LH et al. ( 2021 ) . Author Correction: Postprandial glycaemic dips predict appetite and energy intake in healthy individuals . Nature Metabolism vol. 3 , ( 7 ) 1032 - 1032 .

Tura A, Grespan E, Göbl CS, Koivula RW, Franks PW, Pearson ER, Walker M, Forgie IM et al. ( 2021 ) . Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study . Diabetes vol. 70 , ( 9 ) 2092 - 2106 .

Franks PW, Melén E, Friedman M, Sundström J, Kockum I, Klareskog L, Almqvist C, Bergen SE et al. ( 2021 ) . Technological readiness and implementation of genomic‐driven precision medicine for complex diseases . Journal of Internal Medicine vol. 290 , ( 3 ) 602 - 620 .

Slieker RC, Donnelly LA, Fitipaldi H, Bouland GA, Giordano GN, Åkerlund M, Gerl MJ, Ahlqvist E et al. ( 2021 ) . Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study . Diabetologia vol. 64 , ( 9 ) 1982 - 1989 .

Mazidi M, Valdes AM, Ordovas JM, Hall WL, Pujol JC, Wolf J, Hadjigeorgiou G, Segata N et al. ( 2021 ) . Meal-induced inflammation: postprandial insights from the Personalised REsponses to DIetary Composition Trial (PREDICT) study in 1000 participants . American Journal of Clinical Nutrition vol. 114 , ( 3 ) 1028 - 1038 .

BILLINGS LK, JABLONSKI KA, FRANKS PW, GOLDBERG RB, HIVERT M-F, KAHN SE, KNOWLER WC, LEE C et al. ( 2021 ) . 249-OR: Type 2 Diabetes (T2D) Genetic Clusters for Association with Glycemic Responses to Intervention for Diabetes Prevention . Diabetes vol. 70 , ( Supplement_1 )

MCCAFFERY J, JABLONSKI KA, PAN Q, ASTRUP A, CHRISTIANSEN MR, CORSO LM, FLOREZ JC, FRANKS PW et al. ( 2021 ) . 250-OR: Higher Genetic Risk Score Predicts Smaller Waist Circumference Change over One Year across Five Lifestyle Intervention Clinical Trials . Diabetes vol. 70 , ( Supplement_1 )

LI JH, PERRY JA, JABLONSKI KA, CHEN L, SRINIVASAN S, TODD JN, HARDEN M, MERCADER JM et al. ( 2021 ) . 28-OR: Identification of Ancestry-Specific Alleles in a Genome-Wide Association Study (GWAS) for Metformin (MET) Response in the Diabetes Prevention Program (DPP) . Diabetes vol. 70 , ( Supplement_1 )

Merino J, Berry S, Ganesh S, Capdevila J, Drew D, Bakker E, Wolf J, Franks P et al. ( 2021 ) . Precision Nutrition and Reliability of Continuous Glucose Monitors: Insights From the PREDICT Study . Current Developments in Nutrition vol. 5 , ( Suppl 2 )

Chen J, Spracklen CN, Marenne G, Varshney A, Corbin LJ, Luan J, Willems SM, Wu Y et al. ( 2021 ) . The trans-ancestral genomic architecture of glycemic traits . Nature Genetics vol. 53 , ( 6 ) 840 - 860 .

Sudre CH, Murray B, Varsavsky T, Graham MS, Penfold RS, Bowyer RC, Pujol JC, Klaser K et al. ( 2021 ) . Author Correction: Attributes and predictors of long COVID . Nature Medicine vol. 27 , ( 6 ) 1116 - 1116 .

Louca P, Murray B, Klaser K, Graham MS, Mazidi M, Leeming ER, Thompson E, Bowyer R et al. ( 2021 ) . Modest effects of dietary supplements during the COVID-19 pandemic: insights from 445 850 users of the COVID-19 Symptom Study app . BMJ Nutrition Prevention & Health vol. 4 , ( 1 ) 149 - 157 .

Wyatt P, Berry SE, Finlayson G, O’Driscoll R, Hadjigeorgiou G, Drew DA, Khatib HA, Nguyen LH et al. ( 2021 ) . Postprandial glycaemic dips predict appetite and energy intake in healthy individuals . Nature Metabolism vol. 3 , ( 4 ) 523 - 529 .

Molteni E, Astley CM, Ma W, Sudre CH, Magee LA, Murray B, Fall T, Gomez MF et al. ( 2021 ) . Symptoms and syndromes associated with SARS-CoV-2 infection and severity in pregnant women from two community cohorts . Scientific Reports vol. 11 , ( 1 )

Sudre CH, Lee KA, Lochlainn MN, Varsavsky T, Murray B, Graham MS, Menni C, Modat M et al. ( 2021 ) . Symptom clusters in COVID-19: A potential clinical prediction tool from the COVID Symptom Study app . Science Advances vol. 7 , ( 12 ) eabd4177 - eabd4177 .

Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B et al. ( 2021 ) . Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals . Nature Genetics vol. 53 , ( 5 ) 762 - 762 .

Asnicar F, Leeming ER, Dimidi E, Mazidi M, Franks PW, Al Khatib H, Valdes AM, Davies R et al. ( 2021 ) . Blue poo: impact of gut transit time on the gut microbiome using a novel marker . Gut vol. 70 , ( 9 ) 1665 - 1674 .

Sudre CH, Murray B, Varsavsky T, Graham MS, Penfold RS, Bowyer RC, Pujol JC, Klaser K et al. ( 2021 ) . Attributes and predictors of long COVID . Nature Medicine vol. 27 , ( 4 ) 626 - 631 .

Lagou V, Mägi R, Hottenga J-J, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D et al. ( 2021 ) . Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability . Nature Communications vol. 12 , ( 1 )

Raghavan S, Jablonski K, Delahanty LM, Maruthur NM, Leong A, Franks PW, Knowler WC, Florez JC et al. ( 2021 ) . Interaction of diabetes genetic risk and successful lifestyle modification in the Diabetes Prevention Programme . Diabetes Obesity and Metabolism vol. 23 , ( 4 ) 1030 - 1040 .

Herdenberg C, Mutie PM, Billing O, Abdullah A, Strawbridge RJ, Dahlman I, Tuck S, Holmlund C et al. ( 2021 ) . LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes . Communications Biology vol. 4 , ( 1 )

Jönsson J, Renault KM, García-Calzón S, Perfilyev A, Estampador AC, Nørgaard K, Lind MV, Vaag A et al. ( 2021 ) . Lifestyle Intervention in Pregnant Women With Obesity Impacts Cord Blood DNA Methylation, Which Associates With Body Composition in the Offspring . Diabetes vol. 70 , ( 4 ) 854 - 866 .

Asnicar F, Berry SE, Valdes AM, Nguyen LH, Piccinno G, Drew DA, Leeming E, Gibson R et al. ( 2021 ) . Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals . Nature Medicine vol. 27 , ( 2 ) 321 - 332 .

Lagou V, Mägi R, Hottenga J-J, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D et al. ( 2021 ) . Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability . Nature Communications vol. 12 , ( 1 )

Mutie PM, Pomares-Millan H, Atabaki-Pasdar N, Jordan N, Adams R, Daly NL, Tajes JF, Giordano GN et al. ( 2021 ) . Author Correction: An investigation of causal relationships between prediabetes and vascular complications . Nature Communications vol. 12 , ( 1 )

Palacios C, Trak-Fellermeier MA, Melendez M, Campos M, Pomeroy J, Guo K, Franks PW, Joshipura K ( 2021 ) . Associations between vitamin D levels and glucose metabolism markers among pregnant women and their infants in Puerto Rico . Nutrición Hospitalaria vol. 38 , ( 6 ) 1224 - 1231 .

Bizzotto R, Jennison C, Jones AG, Kurbasic A, Tura A, Kennedy G, Bell JD, Thomas EL et al. ( 2020 ) . Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study . Diabetes Care vol. 44 , ( 2 ) 511 - 518 .

Varsavsky T, Graham MS, Canas LS, Ganesh S, Pujol JC, Sudre CH, Murray B, Modat M et al. ( 2020 ) . Detecting COVID-19 infection hotspots in England using large-scale self-reported data from a mobile application: a prospective, observational study . The Lancet Public Health vol. 6 , ( 1 ) e21 - e29 .

Gudmundsdottir V, Pedersen HK, Mazzoni G, Allin KH, Artati A, Beulens JW, Banasik K, Brorsson C et al. ( 2020 ) . Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study . Genome Medicine vol. 12 , ( 1 )

Obura M, Beulens JWJ, Slieker R, Koopman ADM, Hoekstra T, Nijpels G, Elders P, Koivula RW et al. ( 2020 ) . Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study . PLOS ONE vol. 15 , ( 11 )

Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B et al. ( 2020 ) . Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals . Nature Genetics vol. 52 , ( 12 ) 1314 - 1332 .

Redman LM, Drews KL, Klein S, Van Horn L, Wing RR, Pi-Sunyer X, Evans M, Joshipura K et al. ( 2020 ) . Attenuated early pregnancy weight gain by prenatal lifestyle interventions does not prevent gestational diabetes in the LIFE-Moms consortium . Diabetes Research and Clinical Practice vol. 171 ,

Jujić A, Nilsson PM, Atabaki-Pasdar N, Dieden A, Tuomi T, Franks PW, Holst JJ, Torekov SS et al. ( 2020 ) . Glucose-Dependent Insulinotropic Peptide in the High-Normal Range Is Associated With Increased Carotid Intima-Media Thickness . Diabetes Care vol. 44 , ( 1 ) 224 - 230 .

Zheng J-S, Luan J, Sofianopoulou E, Imamura F, Stewart ID, Day FR, Pietzner M, Wheeler E et al. ( 2020 ) . Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations . Diabetes Care vol. 44 , ( 1 ) 98 - 106 .

Koivula RW, Atabaki-Pasdar N, Giordano GN, White T, Adamski J, Bell JD, Beulens J, Brage S et al. ( 2020 ) . Correction to: The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study . Diabetologia vol. 64 , ( 1 ) 260 - 261 .

Cai L, Wheeler E, Kerrison ND, Luan J, Deloukas P, Franks PW, Amiano P, Ardanaz E et al. ( 2020 ) . Genome-wide association analysis of type 2 diabetes in the EPIC-InterAct study . Scientific Data vol. 7 , ( 1 )

Riddle MC, Philipson LH, Rich SS, Carlsson A, Franks PW, Greeley SAW, Nolan JJ, Pearson ER et al. ( 2020 ) . Monogenic Diabetes: From Genetic Insights to Population-Based Precision in Care. Reflections From a Diabetes Care Editors’ Expert Forum . Diabetes Care vol. 43 , ( 12 ) 3117 - 3128 .

Bar N, Korem T, Weissbrod O, Zeevi D, Rothschild D, Leviatan S, Kosower N, Lotan-Pompan M et al. ( 2020 ) . A reference map of potential determinants for the human serum metabolome . Nature vol. 588 , ( 7836 ) 135 - 140 .

Timmins IR, Zaccardi F, Nelson CP, Franks PW, Yates T, Dudbridge F ( 2020 ) . Author Correction: Genome-wide association study of self-reported walking pace suggests beneficial effects of brisk walking on health and survival . Communications Biology vol. 3 , ( 1 )

Obura M, Beulens JWJ, Slieker R, Koopman ADM, Hoekstra T, Nijpels G, Elders P, Dekker JM et al. ( 2020 ) . Clinical profiles of post‐load glucose subgroups and their association with glycaemic traits over time: An IMI‐DIRECT study . Diabetic Medicine vol. 38 , ( 2 )

Murray B, Kerfoot E, Graham MS, Sudre CH, Molteni E, Canas LS, Antonelli M, Klaser K et al. ( 2020 ) . Accessible Data Curation and Analytics for International-Scale Citizen Science Datasets .

Timmins IR, Zaccardi F, Nelson CP, Franks PW, Yates T, Dudbridge F ( 2020 ) . Genome-wide association study of self-reported walking pace suggests beneficial effects of brisk walking on health and survival . Communications Biology vol. 3 , ( 1 )

Berry SE, Valdes AM, Drew DA, Asnicar F, Mazidi M, Wolf J, Capdevila J, Hadjigeorgiou G et al. ( 2020 ) . Publisher Correction: Human postprandial responses to food and potential for precision nutrition . Nature Medicine vol. 26 , ( 11 ) 1802 - 1802 .

Folkersen L, Gustafsson S, Wang Q, Hansen DH, Hedman ÅK, Schork A, Page K, Zhernakova DV et al. ( 2020 ) . Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals . Nature Metabolism vol. 2 , ( 10 ) 1135 - 1148 .

Zheng J-S, Luan J, Sofianopoulou E, Sharp SJ, Day FR, Imamura F, Gundersen TE, Lotta LA et al. ( 2020 ) . The association between circulating 25-hydroxyvitamin D metabolites and type 2 diabetes in European populations: A meta-analysis and Mendelian randomisation analysis . PLOS Medicine vol. 17 , ( 10 )

Deshmukh HA, Madsen AL, Viñuela A, Have CT, Grarup N, Tura A, Mahajan A, Heggie AJ et al. ( 2020 ) . Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity . The Journal of Clinical Endocrinology & Metabolism vol. 106 , ( 1 ) 80 - 90 .

García-Calzón S, Perfilyev A, Martinell M, Ustinova M, Kalamajski S, Franks PW, Bacos K, Elbere I et al. ( 2020 ) . Epigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes . Science Translational Medicine vol. 12 , ( 561 )

Mutie PM, Pomares-Millan H, Atabaki-Pasdar N, Jordan N, Adams R, Daly NL, Tajes JF, Giordano GN et al. ( 2020 ) . An investigation of causal relationships between prediabetes and vascular complications . Nature Communications vol. 11 , ( 1 )

Lee KA, Ma W, Sikavi DR, Drew DA, Nguyen LH, Bowyer RCE, Cardoso MJ, Fall T et al. ( 2020 ) . Cancer and Risk of COVID‐19 Through a General Community Survey . The Oncologist vol. 26 , ( 1 ) e182 - e185 .

Ibsen DB, Steur M, Imamura F, Overvad K, Schulze MB, Bendinelli B, Guevara M, Agudo A et al. ( 2020 ) . Replacement of Red and Processed Meat With Other Food Sources of Protein and the Risk of Type 2 Diabetes in European Populations: The EPIC-InterAct Study . Diabetes Care vol. 43 , ( 11 )

Franks PW, Pomares-Millan H ( 2020 ) . Next-generation epidemiology: the role of high-resolution molecular phenotyping in diabetes research . Diabetologia vol. 63 , ( 12 ) 2521 - 2532 .

Van Zuydam NR, Ladenvall C, Voight BF, Strawbridge RJ, Fernandez-Tajes J, Rayner NW, Robertson NR, Mahajan A et al. ( 2020 ) . Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus . Circulation: Genomic and Precision Medicine vol. 13 , ( 6 ) 640 - 648 .

Poveda A, Atabaki‐Pasdar N, Ahmad S, Hallmans G, Renström F, Franks PW ( 2020 ) . Association of Established Blood Pressure Loci With 10‐Year Change in Blood Pressure and Their Ability to Predict Incident Hypertension . Journal of the American Heart Association vol. 9 , ( 16 )

Eriksen R, Perez IG, Posma JM, Haid M, Sharma S, Prehn C, Thomas LE, Koivula RW et al. ( 2020 ) . Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study . EBioMedicine vol. 58 ,

Nguyen LH, Drew DA, Graham MS, Joshi AD, Guo C-G, Ma W, Mehta RS, Warner ET et al. ( 2020 ) . Risk of COVID-19 among front-line health-care workers and the general community: a prospective cohort study . The Lancet Public Health vol. 5 , ( 9 ) e475 - e483 .

Haslam DE, Li J, Liang L, Martinez M, Palacios C, Trak-Fellermeier MA, Franks PW, Joshipura K et al. ( 2020 ) . Changes in Metabolites During an Oral Glucose Tolerance Test in Early and Mid-Pregnancy: Findings from the PEARLS Randomized, Controlled Lifestyle Trial . Metabolites vol. 10 , ( 7 )

Zheng J-S, Sharp SJ, Imamura F, Chowdhury R, Gundersen TE, Steur M, Sluijs I, van der Schouw YT et al. ( 2020 ) . Association of plasma biomarkers of fruit and vegetable intake with incident type 2 diabetes: EPIC-InterAct case-cohort study in eight European countries . The BMJ vol. 370 ,

Chan AT, Drew DA, Nguyen LH, Joshi AD, Ma W, Guo C-G, Lo C-H, Mehta RS et al. ( 2020 ) . The COronavirus Pandemic Epidemiology (COPE) Consortium: A Call to Action . Cancer Epidemiology Biomarkers & Prevention vol. 29 , ( 7 ) 1283 - 1289 .

Chung WK, Erion K, Florez JC, Hattersley AT, Hivert M-F, Lee CG, McCarthy MI, Nolan JJ et al. ( 2020 ) . Precision medicine in diabetes: a Consensus Report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) . Diabetologia vol. 63 , ( 9 ) 1671 - 1693 .

Atabaki-Pasdar N, Ohlsson M, Viñuela A, Frau F, Pomares-Millan H, Haid M, Jones AG, Thomas EL et al. ( 2020 ) . Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts . PLOS Medicine vol. 17 , ( 6 )

Berry SE, Valdes AM, Drew DA, Asnicar F, Mazidi M, Wolf J, Capdevila J, Hadjigeorgiou G et al. ( 2020 ) . Human postprandial responses to food and potential for precision nutrition . Nature Medicine vol. 26 , ( 6 ) 964 - 973 .

Chung WK, Erion K, Florez JC, Hattersley AT, Hivert M-F, Lee CG, McCarthy MI, Nolan JJ et al. ( 2020 ) . Precision Medicine in Diabetes: A Consensus Report From the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) . Diabetes Care vol. 43 , ( 7 ) 1617 - 1635 .

Berry S, Valdes A, Segata N, Chan A, Davies R, Drew D, Franks P, Spector T ( 2020 ) . Personal metabolic responses to food predicted using multi-omics machine learning in 1,100 twins and singletons: The PREDICT I Study . Proceedings of The Nutrition Society vol. 79 , ( OCE2 )

Berry S, Franks P, Segata N, Chan A, Davies R, Drew D, Spector T, Valdes A ( 2020 ) . Postprandial lipemia and CVD; does the magnitude, peak concentration or duration impact intermediary cardiometabolic risk factors differentially? PREDICT I Study . Proceedings of The Nutrition Society vol. 79 , ( OCE2 )

FRANKS PW, BERRY S, VALDES AM, DREW DA, DAVIES RJ, MERINO J, CHAN AT, SEGATA N et al. ( 2020 ) . 228-OR: Decoding Human Postprandial Responses to Food and Their Potential for Precision Nutrition: The PREDICT 1 Study . Diabetes vol. 69 , ( Supplement_1 )

Berry S, Wyatt P, Franks P, Blundell J, O’Driscoll R, Wolf J, Hadjigeorgiou G, Drew D et al. ( 2020 ) . Effect of Postprandial Glucose Dips on Hunger and Energy Intake in 1102 Subjects in US and UK: The PREDICT 1 Study . Current Developments in Nutrition vol. 4 , ( Suppl 2 )

Berry S, Mazidi M, Franks P, Valdes A, Sattar N, Wolf J, Hadjigeorgiou G, Drew D et al. ( 2020 ) . Impact of Postprandial Lipemia and Glycemia on Inflammatory Factors in over 1000 Individuals in the US and UK: Insights from the PREDICT 1 and InterCardio Studies . Current Developments in Nutrition vol. 4 , ( Suppl 2 )

Berry S, Ordovas J, Asnicar F, Valdes A, Franks P, Wolf J, Hadjigeorgiou G, Drew D et al. ( 2020 ) . Influence of Gut Microbial Communities on Fasting and Postprandial Lipids and Circulating Metabolites: The PREDICT 1 Study . Current Developments in Nutrition vol. 4 , ( Suppl 2 )

Spector T, Asnicar F, Berry S, Valdes A, Franks P, Wolf J, Hadjigeorgiou G, Le Roy C et al. ( 2020 ) . Microbiome Signatures of Nutrients, Foods and Dietary Patterns: Potential for Personalized Nutrition from The PREDICT 1 Study . Current Developments in Nutrition vol. 4 , ( Suppl 2 )

Okuyama K, Li X, Abe T, Hamano T, Franks PW, Nabika T, Sundquist K ( 2020 ) . Fast food outlets, physical activity facilities, and obesity among adults: a nationwide longitudinal study from Sweden . International Journal of Obesity vol. 44 , ( 8 ) 1703 - 1711 .

Riddle MC, Buse JB, Franks PW, Knowler WC, Ratner RE, Selvin E, Wexler DJ, Kahn SE ( 2020 ) . COVID-19 in People With Diabetes: Urgently Needed Lessons From Early Reports . Diabetes Care vol. 43 , ( 7 ) 1378 - 1381 .

de las Fuentes L, Sung YJ, Noordam R, Winkler T, Feitosa MF, Schwander K, Bentley AR, Brown MR et al. ( 2020 ) . Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci . Molecular Psychiatry

Drew DA, Nguyen LH, Steves CJ, Menni C, Freydin M, Varsavsky T, Sudre CH, Cardoso MJ et al. ( 2020 ) . Rapid implementation of mobile technology for real-time epidemiology of COVID-19 . Science vol. 368 , ( 6497 ) 1362 - 1367 .

Li C, Stoma S, Lotta LA, Warner S, Albrecht E, Allione A, Arp PP, Broer L et al. ( 2020 ) . Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length . American Journal of Human Genetics vol. 106 , ( 3 ) 389 - 404 .

Trak-Fellermeier MA, Campos M, Meléndez M, Pomeroy J, Palacios C, Rivera-Viñas J, Méndez K, Febo I et al. ( 2020 ) . PEARLS Randomized Lifestyle Trial in Pregnant Hispanic Women with Overweight/Obesity: Gestational Weight Gain and Offspring Birthweight [Corrigendum] . Diabetes Metabolic Syndrome and Obesity vol. 13 , ( 0 ) 499 - 499 .

Koivula RW, Atabaki-Pasdar N, Giordano GN, White T, Adamski J, Bell JD, Beulens J, Brage S et al. ( 2020 ) . The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study . Diabetologia vol. 63 , ( 4 ) 744 - 756 .

Jujić A, Atabaki-Pasdar N, Nilsson PM, Almgren P, Hakaste L, Tuomi T, Berglund LM, Franks PW et al. ( 2020 ) . Glucose-dependent insulinotropic peptide and risk of cardiovascular events and mortality: a prospective study . Diabetologia vol. 63 , ( 5 ) 1043 - 1054 .

Haworth S, Esberg A, Holgerson PL, Kuja-Halkola R, Timpson NJ, Magnusson PKE, Franks PW, Johansson I ( 2020 ) . Heritability of Caries Scores, Trajectories, and Disease Subtypes . Journal of Dental Research vol. 99 , ( 3 ) 264 - 270 .

Zaccardi F, Franks PW, Dudbridge F, Davies MJ, Khunti K, Yates T ( 2019 ) . Mortality risk comparing walking pace to handgrip strength and a healthy lifestyle: A UK Biobank study . European Journal of Preventive Cardiology vol. 28 , ( 7 ) 704 - 712 .

Merino J, Jablonski KA, Mercader JM, Kahn SE, Chen L, Harden M, Delahanty LM, Araneta MRG et al. ( 2019 ) . Interaction Between Type 2 Diabetes Prevention Strategies and Genetic Determinants of Coronary Artery Disease on Cardiometabolic Risk Factors . Diabetes vol. 69 , ( 1 ) 112 - 120 .

( 2019 ) . Quality of dietary fat and genetic risk of type 2 diabetes: individual participant data meta-analysis . The BMJ vol. 367 ,

Imamura F, Schulze MB, Sharp SJ, Guevara M, Romaguera D, Bendinelli B, Salamanca-Fernández E, Ardanaz E et al. ( 2019 ) . Estimated Substitution of Tea or Coffee for Sugar-Sweetened Beverages Was Associated with Lower Type 2 Diabetes Incidence in Case–Cohort Analysis across 8 European Countries in the EPIC-InterAct Study . Journal of Nutrition vol. 149 , ( 11 ) 1985 - 1993 .

Timpka S, Hughes AD, Chaturvedi N, Franks PW, Lawlor DA, Rich‐Edwards JW, Fraser A ( 2019 ) . Birth weight and cardiac function assessed by echocardiography in adolescence: Avon Longitudinal Study of Parents and Children . Ultrasound in Obstetrics and Gynecology vol. 54 , ( 2 ) 225 - 231 .

Phelan S, Clifton RG, Haire-Joshu D, Redman LM, Van Horn L, Evans M, Joshipura K, Couch KA et al. ( 2019 ) . One-year postpartum anthropometric outcomes in mothers and children in the LIFE-Moms lifestyle intervention clinical trials . International Journal of Obesity vol. 44 , ( 1 ) 57 - 68 .

Shungin D, Haworth S, Divaris K, Agler CS, Kamatani Y, Keun Lee M, Grinde K, Hindy G et al. ( 2019 ) . Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data . Nature Communications vol. 10 , ( 1 )

Wilman HR, Parisinos CA, Atabaki-Pasdar N, Kelly M, Thomas EL, Neubauer S, Jennison C, Ehrhardt B et al. ( 2019 ) . Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration . Journal of Hepatology vol. 71 , ( 3 ) 594 - 602 .

Koivula RW, Forgie IM, Kurbasic A, Viñuela A, Heggie A, Giordano GN, Hansen TH, Hudson M et al. ( 2019 ) . Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium . Diabetologia vol. 62 , ( 9 ) 1601 - 1615 .

Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T et al. ( 2019 ) . Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity . Nature Genetics vol. 51 , ( 7 ) 1191 - 1192 .

KOIVULA RW, CONSORTIUM I-D, FRANKS PW, HANSEN TH, LAAKSO M, PEARSON E, RUTTERS F, KARPE F et al. ( 2019 ) . 1845-P: Divergent Effects on T2D of Alleles Associated with Increased Liver Fat Reflect Differential Impact on Hepatic Glucose and Lipid Output: An IMI DIRECT Study . Diabetes vol. 68 , ( Supplement_1 )

HONG M-G, VIÑUELA A, HÄUSSLER RS, DALE M, KOIVULA RW, FERNANDEZ-TAJES J, MAHAJAN A, BIZZOTTO R et al. ( 2019 ) . 189-OR: Plasma Proteome Profiling of Prediabetes and Diabetes Progression: An IMI Direct Study . Diabetes vol. 68 , ( Supplement_1 )

RAGHAVAN S, JABLONSKI KA, DELAHANTY LM, MARUTHUR N, LEONG A, FRANKS PW, KNOWLER WC, FLOREZ JC et al. ( 2019 ) . 307-OR: Interaction of Diabetes Genetic Risk and Successful Lifestyle Modification in the Diabetes Prevention Program . Diabetes vol. 68 , ( Supplement_1 )

FRANKS PW, BERRY S, CHAN AT, DAVIES RJ, DREW DA, SPECTOR TD, VALDES AM ( 2019 ) . 69-LB: Postprandial 2-hr Rise in Insulin Is a Strong Predictor of Glycemic Responses to Different Meals in Healthy and Prediabetic Individuals: The PREDICT I Study . Diabetes vol. 68 , ( Supplement_1 )

SPECTOR TD, BERRY S, CHAN AT, DAVIES RJ, DREW DA, VALDES AM, FRANKS PW ( 2019 ) . 71-LB: Personal Metabolic Responses to Food Predicted Using Multi-omics Machine Learning: The PREDICT I Study . Diabetes vol. 68 , ( Supplement_1 )

Spector T, Berry S, Valdes A, Drew D, Chan A, Franks P, Asnicar F, Segata N et al. ( 2019 ) . Integrating Metagenomic Information into Personalized Nutrition Tools: The PREDICT I Study (P20-005-19) . Current Developments in Nutrition vol. 3 , ( Suppl 1 )

Berry S, Valdes A, Davies R, Al Khatib H, Delahanty L, Drew D, Chan AT, Segata N et al. ( 2019 ) . Large Inter-individual Variation in Postprandial Lipemia Following a Mixed Meal in over 1000 Twins and Singletons from the UK and US: The PREDICT I Study (OR19-06-19) . Current Developments in Nutrition vol. 3 , ( Suppl 1 )

Berry S, Valdes A, Davies R, Delahanty L, Drew D, Chan AT, Segata N, Franks P et al. ( 2019 ) . Predicting Personal Metabolic Responses to Food Using Multi-omics Machine Learning in over 1000 Twins and Singletons from the UK and US: The PREDICT I Study (OR31-01-19) . Current Developments in Nutrition vol. 3 , ( Suppl 1 )

Jannasch F, Kröger J, Agnoli C, Barricarte A, Boeing H, Cayssials V, Colorado-Yohar S, Dahm CC et al. ( 2019 ) . Generalizability of a Diabetes-Associated Country-Specific Exploratory Dietary Pattern Is Feasible Across European Populations . Journal of Nutrition vol. 149 , ( 6 ) 1047 - 1055 .

Apolzan JW, Venditti EM, Edelstein SL, Knowler WC, Dabelea D, Boyko EJ, Pi-Sunyer X, Kalyani RR et al. ( 2019 ) . Long-Term Weight Loss With Metformin or Lifestyle Intervention in the Diabetes Prevention Program Outcomes Study . Annals of Internal Medicine vol. 170 , ( 10 ) 682 - 690 .

Jimenez-Corona A, Nelson RG, Jimenez-Corona ME, Franks PW, Aguilar-Salinas CA, Graue-Hernandez EO, Hernandez-Jimenez S, Hernandez-Avila M ( 2019 ) . Disparities in prediabetes and type 2 diabetes prevalence between indigenous and nonindigenous populations from Southeastern Mexico: The Comitan Study . Journal of Clinical & Translational Endocrinology vol. 16 ,

Njølstad PR, Andreassen OA, Brunak S, Børglum AD, Dillner J, Esko T, Franks PW, Freimer N et al. ( 2019 ) . Roadmap for a precision-medicine initiative in the Nordic region . Nature Genetics vol. 51 , ( 6 ) 924 - 930 .

Sung YJ, de las Fuentes L, Winkler TW, Chasman DI, Bentley AR, Kraja AT, Ntalla I, Warren HR et al. ( 2019 ) . A multi-ancestry genome-wide study incorporating gene–smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure . Human Molecular Genetics vol. 28 , ( 15 ) 2615 - 2633 .

Bentley AR, Sung YJ, Brown MR, Winkler TW, Kraja AT, Ntalla I, Schwander K, Chasman DI et al. ( 2019 ) . Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids . Nature Genetics vol. 51 , ( 4 ) 636 - 648 .

Dawed AY, Zhou K, van Leeuwen N, Mahajan A, Robertson N, Koivula R, Elders PJM, Rauh SP et al. ( 2019 ) . Variation in the Plasma Membrane Monoamine Transporter (PMAT) (Encoded by SLC29A4) and Organic Cation Transporter 1 (OCT1) (Encoded by SLC22A1) and Gastrointestinal Intolerance to Metformin in Type 2 Diabetes: An IMI DIRECT Study . Diabetes Care vol. 42 , ( 6 ) 1027 - 1033 .

Dudding T, Haworth S, Lind PA, Sathirapongsasuti JF, Tung JY, Mitchell R, Colodro-Conde L, Medland SE et al. ( 2019 ) . Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci . Nature Communications vol. 10 , ( 1 )

Justice AE, Karaderi T, Highland HM, Young KL, Graff M, Lu Y, Turcot V, Auer PL et al. ( 2019 ) . Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution . Nature Genetics vol. 51 , ( 3 ) 452 - 469 .

Vissers LET, Sluijs I, van der Schouw YT, Forouhi NG, Imamura F, Burgess S, Barricarte A, Boeing H et al. ( 2019 ) . Dairy Product Intake and Risk of Type 2 Diabetes in EPIC-InterAct: A Mendelian Randomization Study . Diabetes Care vol. 42 , ( 4 )

Trak-Fellermeier MA, Campos M, Meléndez M, Pomeroy J, Palacios C, Rivera-Viñas J, Méndez K, Febo I et al. ( 2019 ) . PEARLS randomized lifestyle trial in pregnant Hispanic women with overweight/obesity: gestational weight gain and offspring birthweight . Diabetes Metabolic Syndrome and Obesity vol. 12 , ( 0 ) 225 - 238 .

de Vries PS, Brown MR, Bentley AR, Sung YJ, Winkler TW, Ntalla I, Schwander K, Kraja AT et al. ( 2019 ) . Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions . American Journal of Epidemiology vol. 188 , ( 6 ) 1033 - 1054 .

Kilpeläinen TO, Bentley AR, Noordam R, Sung YJ, Schwander K, Winkler TW, Jakupović H, Chasman DI et al. ( 2019 ) . Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity . Nature Communications vol. 10 , ( 1 )

Erzurumluoglu AM, Liu M, Jackson VE, Barnes DR, Datta G, Melbourne CA, Young R, Batini C et al. ( 2019 ) . Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci . Molecular Psychiatry vol. 25 , ( 10 ) 2392 - 2409 .

Wilman HR, Parisinos CA, Atabaki-Pasdar N, Kelly M, Thomas EL, Neubauer S, Hingorani A, Mahajan A et al. ( 2019 ) . Genome-wide association study of MRI liver iron content in 9,800 individuals yields new insights into its link with hepatic and extrahepatic diseases . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 27 , 1148 - 1148 .

Ng N, Willems SM, Fernandez J, Fine RS, Wheeler E, Wessel J, Kitajima H, Marenne G et al. ( 2019 ) . Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation .

Brazel DM, Jiang Y, Hughey JM, Turcot V, Zhan X, Gong J, Batini C, Weissenkampen JD et al. ( 2018 ) . Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use . Biological Psychiatry

Takeuchi F, Akiyama M, Matoba N, Katsuya T, Nakatochi M, Tabara Y, Narita A, Saw W-Y et al. ( 2018 ) . Interethnic analyses of blood pressure loci in populations of East Asian and European descent . Nature Communications vol. 9 , ( 1 )

Kurbasic A, Fraser A, Mogren I, Hallmans G, Franks PW, Rich-Edwards JW, Timpka S ( 2018 ) . Maternal Hypertensive Disorders of Pregnancy and Offspring Risk of Hypertension: A Population-Based Cohort and Sibling Study . American Journal of Hypertension vol. 32 , ( 4 ) 331 - 334 .

Timpka S, Stuart JJ, Tanz LJ, Hu FB, Franks PW, Rich-Edwards JW ( 2018 ) . Postpregnancy BMI in the Progression From Hypertensive Disorders of Pregnancy to Type 2 Diabetes . Diabetes Care vol. 42 , ( 1 )

Zheng J-S, Imamura F, Sharp SJ, van der Schouw YT, Sluijs I, Gundersen TE, Ardanaz E, Boeing H et al. ( 2018 ) . Association of Plasma Vitamin D Metabolites With Incident Type 2 Diabetes: EPIC-InterAct Case-Cohort Study . The Journal of Clinical Endocrinology & Metabolism vol. 104 , ( 4 ) 1293 - 1303 .

Ji Y, Yiorkas AM, Frau F, Mook-Kanamori D, Staiger H, Thomas EL, Atabaki-Pasdar N, Campbell A et al. ( 2018 ) . Genome-Wide and Abdominal MRI-Imaging Data Provides Evidence that a Genetically Determined Favourable Adiposity Phenotype is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease and Hypertension . Diabetes vol. 68 , ( 1 )

de las Heras Gala T, Herder C, Rutters F, Carstensen‐Kirberg M, Huth C, Stehouwer CDA, Nijpels G, Schalkwijk C et al. ( 2018 ) . Association of changes in inflammation with variation in glycaemia, insulin resistance and secretion based on the KORA study . Diabetes/Metabolism Research and Reviews vol. 34 , ( 8 )

Fitipaldi H, McCarthy MI, Florez JC, Franks PW ( 2018 ) . A Global Overview of Precision Medicine in Type 2 Diabetes . Diabetes vol. 67 , ( 10 ) 1911 - 1922 .

Timpka S, Markovitz A, Schyman T, Mogren I, Fraser A, Franks PW, Rich-Edwards JW ( 2018 ) . Midlife development of type 2 diabetes and hypertension in women by history of hypertensive disorders of pregnancy . Cardiovascular Diabetology vol. 17 , ( 1 )

Peaceman AM, Clifton RG, Phelan S, Gallagher D, Evans M, Redman LM, Knowler WC, Joshipura K et al. ( 2018 ) . Lifestyle Interventions Limit Gestational Weight Gain in Women with Overweight or Obesity: LIFE‐Moms Prospective Meta‐Analysis . Obesity vol. 26 , ( 9 ) 1396 - 1404 .

Ashar FN, Mitchell RN, Albert CM, Newton-Cheh C, Brody JA, Müller-Nurasyid M, Moes A, Meitinger T et al. ( 2018 ) . A comprehensive evaluation of the genetic architecture of sudden cardiac arrest . European Heart Journal vol. 39 , ( 44 ) 3961 - 3969 .

Franks PW, Timpson NJ ( 2018 ) . Genotype-Based Recall Studies in Complex Cardiometabolic Traits . Circulation Genomic and Precision Medicine vol. 11 , ( 8 )

Timpka S, Fraser A, Schyman T, Stuart JJ, Åsvold BO, Mogren I, Franks PW, Rich-Edwards JW ( 2018 ) . The value of pregnancy complication history for 10-year cardiovascular disease risk prediction in middle-aged women . European Journal of Epidemiology vol. 33 , ( 10 ) 1003 - 1010 .

MAXWELL TJ, JABLONSKI KA, FRANKS PW, KAHN SE, KNOWLER WC, MATHER KJ, FLOREZ JC ( 2018 ) . Quantitative Trait Loci G×E and G×G for Glycemic Traits—Response to Metformin and Placebo in the Diabetes Prevention Program (DPP) . Diabetes vol. 67 , ( Supplement_1 )

Haworth S, Shungin D, Kwak SY, Kim H, West NX, Thomas SJ, Franks PW, Timpson NJ et al. ( 2018 ) . Tooth loss is a complex measure of oral disease: Determinants and methodological considerations . Community Dentistry And Oral Epidemiology vol. 46 , ( 6 ) 555 - 562 .

Haworth S, Shungin D, van der Tas JT, Vucic S, Medina-Gomez C, Yakimov V, Feenstra B, Shaffer JR et al. ( 2018 ) . Consortium-based genome-wide meta-analysis for childhood dental caries traits . Human Molecular Genetics vol. 27 , ( 17 ) 3113 - 3127 .

Feitosa MF, Kraja AT, Chasman DI, Sung YJ, Winkler TW, Ntalla I, Guo X, Franceschini N et al. ( 2018 ) . Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries . PLoS One vol. 13 , ( 6 ) e0198166 - e0198166 .

Keller M, Dalla-Riva J, Kurbasic A, Al-Majdoub M, Spegel P, de Marinis Y, Wierup N, Ling C et al. ( 2018 ) . Genome editing (CRISPR-Cas9) to identify and characterise functional variants determining metformin response . Diabetologie und Stoffwechsel . Conference: „Wissenschaft und klinischer Fortschritt – gemeinsam in die Zukunft“ – www.diabeteskongress.de vol. 13 , 271 - 271 .

Rivas MA, Avila BE, Koskela J, Huang H, Stevens C, Pirinen M, Haritunians T, Neale BM et al. ( 2018 ) . Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population . PLOS Genetics vol. 14 , ( 5 )

Chen Y, Estampador AC, Keller M, Poveda A, Dalla-Riva J, Johansson I, Renström F, Kurbasic A et al. ( 2018 ) . The combined effects of FADS gene variation and dietary fats in obesity-related traits in a population from the far north of Sweden: the GLACIER Study . International Journal of Obesity vol. 43 , ( 4 ) 808 - 820 .

Mahajan A, Wessel J, Willems SM, Zhao W, Robertson NR, Chu AY, Gan W, Kitajima H et al. ( 2018 ) . Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes . Nature Genetics vol. 50 , ( 4 ) 559 - 571 .

Kröger J, Meidtner K, Stefan N, Guevara M, Kerrison ND, Ardanaz E, Aune D, Boeing H et al. ( 2018 ) . Circulating Fetuin-A and Risk of Type 2 Diabetes: A Mendelian Randomization Analysis . Diabetes vol. 67 , ( 6 )

.Franks PW, Merino J ( 2018 ) . Gene-lifestyle interplay in type 2 diabetes . Current Opinion in Genetics & Development vol. 50 , 35 - 40 .

VAN HEEL DA ( 2018 ) . Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference . Nature Communications

Sung YJ, Winkler TW, de las Fuentes L, Bentley AR, Brown MR, Kraja AT, Schwander K, Ntalla I et al. ( 2018 ) . A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure . American Journal of Human Genetics vol. 102 , ( 3 ) 375 - 400 .

Åström DO, Franks PW, Sundquist K ( 2018 ) . Neighborhoods and mortality in Sweden: Is deprivation best assessed nationally or regionally? . Demographic Research vol. 38 , 429 - 450 .

Allin KH, Tremaroli V, Caesar R, Jensen BAH, Damgaard MTF, Bahl MI, Licht TR, Hansen TH et al. ( 2018 ) . Aberrant intestinal microbiota in individuals with prediabetes . Diabetologia vol. 61 , ( 4 ) 810 - 820 .

Flannick J, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R et al. ( 2018 ) . Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls . Scientific Data vol. 5 , ( 1 )

Kamble PG, Gustafsson S, Pereira MJ, Lundkvist P, Cook N, Lind L, Franks PW, Fall T et al. ( 2018 ) . Genotype-based recall to study metabolic effects of genetic variation: a pilot study of PPARG Pro12Ala carriers . Upsala Journal of Medical Sciences vol. 122 , ( 4 ) 1 - 9 .

Ahmad S, Mora S, Franks PW, Orho-Melander M, Ridker PM, Hu FB, Chasman DI ( 2018 ) . Adiposity and Genetic Factors in Relation to Triglycerides and Triglyceride-Rich Lipoproteins in the Women's Genome Health Study . Clinical Chemistry vol. 64 , ( 1 ) 231 - 241 .

Huang T, Ding M, Bergholdt Helle KM, Wang T, Heianza Y, Sun D, Frazier-Wood Alexis C, Aslibekyan S et al. ( 2018 ) . Dairy Consumption and Body Mass Index Among Adults: Mendelian Randomization Analysis of 184802 Individuals from 25 Studies . Clinical Chemistry vol. 64 , ( 1 ) 183 - 191 .

Estampador AC, Franks PW ( 2018 ) . Precision Medicine in Obesity and Type 2 Diabetes: The Relevance of Early-Life Exposures . Clinical Chemistry vol. 64 , ( 1 ) 130 - 141 .

Bennet L, Franks PW, Zöller B, Groop L ( 2017 ) . Family history of diabetes and its relationship with insulin secretion and insulin sensitivity in Iraqi immigrants and native Swedes: a population-based cohort study . Acta Diabetologica vol. 55 , ( 3 ) 233 - 242 .

Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T et al. ( 2017 ) . Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity . Nature Genetics vol. 50 , ( 1 ) 26 - 41 .

Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T et al. ( 2017 ) . Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity . Nat Genet vol. 50 , ( 5 ) 766 - 767 .

Donnelly LA, Zhou K, Doney ASF, Jennison C, Franks PW, Pearson ER ( 2017 ) . Rates of glycaemic deterioration in a real-world population with type 2 diabetes . Diabetologia vol. 61 , ( 3 ) 607 - 615 .

Flannick J, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R et al. ( 2017 ) . Sequence data and association statistics from 12,940 type 2 diabetes cases and controls . Sci Data vol. 4 , 170179 - 170179 .

Timpka S, Stuart JJ, Tanz LJ, Rimm EB, Franks PW, Rich-Edwards JW ( 2017 ) . Lifestyle in Progression From Hypertensive Disorders of Pregnancy to Chronic Hypertension in Nurses' Health Study II . Obstetrical & Gynecological Survey vol. 72 , ( 12 ) 701 - 703 .

Meidtner K, Podmore C, Kröger J, van der Schouw YT, Bendinelli B, Agnoli C, Arriola L, Barricarte A et al. ( 2017 ) . Interaction of Dietary and Genetic Factors Influencing Body Iron Status and Risk of Type 2 Diabetes Within the EPIC-InterAct Study . Diabetes Care vol. 41 , ( 2 )

Zheng J-S, Sharp SJ, Imamura F, Koulman A, Schulze MB, Ye Z, Griffin J, Guevara M et al. ( 2017 ) . Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries: a cross-sectional analysis in the EPIC-InterAct study . BMC Medicine vol. 15 , ( 1 )

Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C et al. ( 2017 ) . Exome-wide association study of plasma lipids in >300,000 individuals . Nature Genetics vol. 49 , ( 12 ) 1758 - 1766 .

Imamura F, Sharp SJ, Koulman A, Schulze MB, Kröger J, Griffin JL, Huerta JM, Guevara M et al. ( 2017 ) . A combination of plasma phospholipid fatty acids and its association with incidence of type 2 diabetes: The EPIC-InterAct case-cohort study . PLOS Medicine vol. 14 , ( 10 )

Kraja AT, Cook JP, Warren HR, Surendran P, Liu C, Evangelou E, Manning AK, Grarup N et al. ( 2017 ) . New Blood Pressure–Associated Loci Identified in Meta-Analyses of 475 000 Individuals . Circulation Genomic and Precision Medicine vol. 10 , ( 5 )

Mutie PM, Giordano GN, Franks PW ( 2017 ) . Lifestyle precision medicine: the next generation in type 2 diabetes prevention? . BMC Medicine vol. 15 , ( 1 )

Brænne I, Willenborg C, Tragante V, Kessler T, Zeng L, Reiz B, Kleinecke M, von Ameln S et al. ( 2017 ) . A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors . Scientific Reports vol. 7 , ( 1 )

Dawed AY, Ali A, Zhou K, Pearson ER, Franks PW ( 2017 ) . Evidence-based prioritisation and enrichment of genes interacting with metformin in type 2 diabetes . Diabetologia vol. 60 , ( 11 ) 2231 - 2239 .

Graff M, Scott RA, Justice AE, Young KL, Feitosa MF, Barata L, Winkler TW, Chu AY et al. ( 2017 ) . Correction: Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults . PLOS Genetics vol. 13 , ( 8 )

Brænne I, Zeng L, Willenborg C, Tragante V, Kessler T, CARDIoGRAM Consortium, CARDIoGRAMplusC4D Consortium, Willer CJ et al. ( 2017 ) . Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk . PLoS One vol. 12 , ( 8 ) e0182999 - e0182999 .

Yates T, Zaccardi F, Dhalwani NN, Davies MJ, Bakrania K, Celis-Morales CA, Gill JMR, Franks PW et al. ( 2017 ) . Association of walking pace and handgrip strength with all-cause, cardiovascular, and cancer mortality: a UK Biobank observational study . European Heart Journal vol. 38 , ( 43 ) 3232 - 3240 .

Nelson CP, Goel A, Butterworth AS, Kanoni S, Webb TR, Marouli E, Zeng L, Ntalla I et al. ( 2017 ) . Association analyses based on false discovery rate implicate new loci for coronary artery disease . Nature Genetics vol. 49 , ( 9 ) 1385 - 1391 .

Willems SM, Wright DJ, Day FR, Trajanoska K, Joshi PK, Morris JA, Matteini AM, Garton FC et al. ( 2017 ) . Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness . Nature Communications vol. 8 , ( 1 )

Timpka S, Stuart JJ, Tanz LJ, Rimm EB, Franks PW, Rich-Edwards JW ( 2017 ) . Lifestyle in progression from hypertensive disorders of pregnancy to chronic hypertension in Nurses’ Health Study II: observational cohort study . The BMJ vol. 358 ,

Shungin D, Deng WQ, Varga TV, Luan J, Mihailov E, Metspalu A, Morris AP, Forouhi NG et al. ( 2017 ) . Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions . PLOS Genetics vol. 13 , ( 6 )

Li SX, Imamura F, Ye Z, Schulze MB, Zheng J, Ardanaz E, Arriola L, Boeing H et al. ( 2017 ) . Interaction between genes and macronutrient intake on the risk of developing type 2 diabetes: systematic review and findings from European Prospective Investigation into Cancer (EPIC)-InterAct . American Journal of Clinical Nutrition vol. 106 , ( 1 ) 263 - 275 .

Scott RA, Scott LJ, Mägi R, Marullo L, Gaulton KJ, Kaakinen M, Pervjakova N, Pers TH et al. ( 2017 ) . An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans . Diabetes vol. 66 , ( 11 )

Graff M, Scott RA, Justice AE, Young KL, Feitosa MF, Barata L, Winkler TW, Chu AY et al. ( 2017 ) . Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults . PLOS Genetics vol. 13 , ( 4 )

Billings LK, Jablonski KA, Warner AS, Cheng Y-C, McAteer JB, Tipton L, Shuldiner AR, Ehrmann DA et al. ( 2017 ) . Variation in Maturity-Onset Diabetes of the Young Genes Influence Response to Interventions for Diabetes Prevention . The Journal of Clinical Endocrinology & Metabolism vol. 102 , ( 8 ) 2678 - 2689 .

Justice AE, Winkler TW, Feitosa MF, Graff M, Fisher VA, Young K, Barata L, Deng X et al. ( 2017 ) . Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits . Nat Commun vol. 8 , 14977 - 14977 .

Manning A, Highland HM, Gasser J, Sim X, Tukiainen T, Fontanillas P, Grarup N, Rivas MA et al. ( 2017 ) . A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk . Diabetes vol. 66 , ( 7 )

Ding M, Huang T, Bergholdt HK, Nordestgaard BG, Ellervik C, Qi L ( 2017 ) . Dairy consumption, systolic blood pressure, and risk of hypertension: Mendelian randomization study . The BMJ vol. 356 ,

Timpka S, Hughes AD, Chaturvedi N, Franks PW, Lawlor DA, Fraser A ( 2017 ) . Abstract P144: Being Born Small for Gestational Age and Later Cardiac Structure and Function in Adolescence . Circulation vol. 135 , ( suppl_1 )

Webb TR, Erdmann J, Stirrups KE, Stitziel NO, Masca NGD, Jansen H, Kanoni S, Nelson CP et al. ( 2017 ) . Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease . J Am Coll Cardiol vol. 69 , ( 7 ) 823 - 836 .

Romieu I, Dossus L, Barquera S, Blottière HM, Franks PW, Gunter M, Hwalla N, Hursting SD et al. ( 2017 ) . Energy balance and obesity: what are the main drivers? . Cancer Causes & Control vol. 28 , ( 3 ) 247 - 258 .

Rauh SP, Heymans MW, Koopman ADM, Nijpels G, Stehouwer CD, Thorand B, Rathmann W, Meisinger C et al. ( 2017 ) . Predicting glycated hemoglobin levels in the non-diabetic general population: Development and validation of the DIRECT-DETECT prediction model - a DIRECT study . PLOS ONE vol. 12 , ( 2 )

Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, Fine RS, Lu Y et al. ( 2017 ) . Rare and low-frequency coding variants alter human adult height . Nature vol. 542 , ( 7640 ) 186 - 190 .

McCaffery JM, Jablonski KA, Franks PW, Delahanty LM, Aroda V, Marrero D, Hamman RF, Horton ES et al. ( 2017 ) . Replication of the Association of BDNF and MC4R Variants With Dietary Intake in the Diabetes Prevention Program . Biopsychosocial Science and Medicine vol. 79 , ( 2 ) 224 - 233 .

Franks PW, Poveda A ( 2017 ) . Lifestyle and precision diabetes medicine: will genomics help optimise the prediction, prevention and treatment of type 2 diabetes through lifestyle therapy? . Diabetologia vol. 60 , ( 5 ) 784 - 792 .

Franks PW ( 2017 ) . Commentary: Mining gene-lifestyle interactions in UK Biobank: all that glitters isn’t gold . International Journal of Epidemiology vol. 46 , ( 2 ) 576 - 577 .

Preiss D, Dawed A, Welsh P, Heggie A, Jones AG, Dekker J, Koivula R, Hansen TH et al. ( 2016 ) . Sustained influence of metformin therapy on circulating glucagon‐like peptide‐1 levels in individuals with and without type 2 diabetes . Diabetes Obesity and Metabolism vol. 19 , ( 3 ) 356 - 363 .

Poveda A, Chen Y, Brändström A, Engberg E, Hallmans G, Johansson I, Renström F, Kurbasic A et al. ( 2016 ) . The heritable basis of gene–environment interactions in cardiometabolic traits . Diabetologia vol. 60 , ( 3 ) 442 - 452 .

Franks PW, Atabaki‐Pasdar N ( 2016 ) . Causal inference in obesity research . Journal of Internal Medicine vol. 281 , ( 3 ) 222 - 232 .

Li M, Li Y, Weeks O, Mijatovic V, Teumer A, Huffman JE, Tromp G, Fuchsberger C et al. ( 2016 ) . SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function . Journal of the American Society of Nephrology vol. 28 , ( 3 ) 981 - 994 .

Atabaki-Pasdar N, Ohlsson M, Shungin D, Kurbasic A, Ingelsson E, Pearson ER, Ali A, Franks PW ( 2016 ) . Statistical power considerations in genotype-based recall randomized controlled trials . Scientific Reports vol. 6 , ( 1 )

Rockette-Wagner B, Storti KL, Dabelea D, Edelstein S, Florez H, Franks PW, Montez MG, Pomeroy J et al. ( 2016 ) . Activity and Sedentary Time 10 Years After a Successful Lifestyle Intervention: The Diabetes Prevention Program . American Journal of Preventive Medicine vol. 52 , ( 3 ) 292 - 299 .

Varga TV, Kurbasic A, Aine M, Eriksson P, Ali A, Hindy G, Gustafsson S, Luan J et al. ( 2016 ) . Novel genetic loci associated with long-term deterioration in blood lipid concentrations and coronary artery disease in European adults . International Journal of Epidemiology vol. 46 , ( 4 ) 1211 - 1222 .

Lotta LA, Gulati P, Day FR, Payne F, Ongen H, van de Bunt M, Gaulton KJ, Eicher JD et al. ( 2016 ) . Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance . Nature Genetics vol. 49 , ( 1 ) 17 - 26 .

Grøntved A, Koivula RW, Johansson I, Wennberg P, Østergaard L, Hallmans G, Renström F, Franks PW ( 2016 ) . Bicycling to Work and Primordial Prevention of Cardiovascular Risk: A Cohort Study Among Swedish Men and Women . Journal of the American Heart Association vol. 5 , ( 11 )

Timpka S, Macdonald‐Wallis C, Hughes AD, Chaturvedi N, Franks PW, Lawlor DA, Fraser A ( 2016 ) . Hypertensive Disorders of Pregnancy and Offspring Cardiac Structure and Function in Adolescence . Journal of the American Heart Association vol. 5 , ( 11 )

Varga TV, Winters AH, Jablonski KA, Horton ES, Khare-Ranade P, Knowler WC, Marcovina SM, Renström F et al. ( 2016 ) . Comprehensive Analysis of Established Dyslipidemia-Associated Loci in the Diabetes Prevention Program . Circulation Genomic and Precision Medicine vol. 9 , ( 6 ) 495 - 503 .

Jakobsdottir J, van der Lee SJ, Bis JC, Chouraki V, Li-Kroeger D, Yamamoto S, Grove ML, Naj A et al. ( 2016 ) . Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease . PLOS Genetics vol. 12 , ( 10 )

Franks PW, Renström F ( 2016 ) . Using Genotype-Based Recall to Estimate the Effects of AMY1 Copy Number Variation in Substrate Metabolism . Diabetes vol. 65 , ( 11 ) 3240 - 3242 .

Franks PW, McCarthy MI ( 2016 ) . Exposing the exposures responsible for type 2 diabetes and obesity . Science vol. 354 , ( 6308 ) 69 - 73 .

Lotta LA, Sharp SJ, Burgess S, Perry JRB, Stewart ID, Willems SM, Luan J, Ardanaz E et al. ( 2016 ) . Association Between Low-Density Lipoprotein Cholesterol–Lowering Genetic Variants and Risk of Type 2 Diabetes: A Meta-analysis . JAMA: The Journal of the American Medical Association vol. 316 , ( 13 ) 1383 - 1391 .

Livingstone KM, Celis-Morales C, Papandonatos GD, Erar B, Florez JC, Jablonski KA, Razquin C, Marti A et al. ( 2016 ) . FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials . The BMJ vol. 354 ,

The InterAct Consortium ( 2016 ) . Investigation of gene–diet interactions in the incretin system and risk of type 2 diabetes: the EPIC-InterAct study . Diabetologia vol. 59 , ( 12 ) 2613 - 2621 .

MUNROE PB ( 2016 ) . Trans-ancestry meta-analyses identify novel rare and common variants associated with blood pressure and hypertension . Nature Genetics

Liu G, Ding M, Chiuve SE, Rimm EB, Franks PW, Meigs JB, Hu FB, Sun Q ( 2016 ) . Plasma Levels of Fatty Acid–Binding Protein 4, Retinol-Binding Protein 4, High-Molecular-Weight Adiponectin, and Cardiovascular Mortality Among Men With Type 2 Diabetes . Arteriosclerosis Thrombosis and Vascular Biology vol. 36 , ( 11 ) 2259 - 2267 .

MUNROE PB ( 2016 ) . The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals . Nature Genetics

Nordström* A, Hadrévi J, Olsson T, Franks PW, Nordström P ( 2016 ) . Higher Prevalence of Type 2 Diabetes in Men Than in Women Is Associated With Differences in Visceral Fat Mass . The Journal of Clinical Endocrinology & Metabolism vol. 101 , ( 10 ) 3740 - 3746 .

Del Gobbo LC, Imamura F, Aslibekyan S, Marklund M, Virtanen JK, Wennberg M, Yakoob MY, Chiuve SE et al. ( 2016 ) . ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies . JAMA Internal Medicine vol. 176 , ( 8 ) 1155 - 1166 .

Kanoni S, Masca NGD, Stirrups KE, Varga TV, Warren HR, Scott RA, Southam L, Zhang W et al. ( 2016 ) . Analysis with the exome array identifies multiple new independent variants in lipid loci . Human Molecular Genetics vol. 25 , ( 18 ) ddw227 - ddw227 .

Brunkwall L, Chen Y, Hindy G, Rukh G, Ericson U, Barroso I, Johansson I, Franks PW et al. ( 2016 ) . Sugar-sweetened beverage consumption and genetic predisposition to obesity in 2 Swedish cohorts 1 , 2 . American Journal of Clinical Nutrition vol. 104 , ( 3 ) 809 - 815 .

Forouhi NG, Imamura F, Sharp SJ, Koulman A, Schulze MB, Zheng J, Ye Z, Sluijs I et al. ( 2016 ) . Association of Plasma Phospholipid n-3 and n-6 Polyunsaturated Fatty Acids with Type 2 Diabetes: The EPIC-InterAct Case-Cohort Study . PLOS Medicine vol. 13 , ( 7 )

Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V, Gaulton KJ, Ma C, Fontanillas P et al. ( 2016 ) . The genetic architecture of type 2 diabetes . Nature vol. 536 , ( 7614 ) 41 - 47 .

Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, Czajkowski J, Esko T et al. ( 2016 ) . Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study . PLoS Genet vol. 12 , ( 6 ) e1006166 - e1006166 .

Scott RA, Freitag DF, Li L, Chu AY, Surendran P, Young R, Grarup N, Stancakova A et al. ( 2016 ) . A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease . Science Translational Medicine vol. 8 , ( 341 ) 341ra76 - 341ra76 .

Hinney A, Kesselmeier M, Jall S, Volckmar A-L, Föcker M, Antel J, Heid IM, Winkler TW et al. ( 2016 ) . Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index . Molecular Psychiatry vol. 22 , ( 2 ) 192 - 201 .

Franks PW, Paré G ( 2016 ) . Putting the Genome in Context: Gene-Environment Interactions in Type 2 Diabetes . Current Diabetes Reports vol. 16 , ( 7 )

Torres R, Soltero S, Trak MA, Tucker CM, Mendez K, Campos M, Willett W, Melendez M et al. ( 2016 ) . Lifestyle modification intervention for overweight and obese Hispanic pregnant women: Development, implementation, lessons learned and future applications . Contemporary Clinical Trials Communications vol. 3 , 111 - 116 .

Ahmad S, Poveda A, Shungin D, Barroso I, Hallmans G, Renström F, Franks PW ( 2016 ) . Established BMI-associated genetic variants and their prospective associations with BMI and other cardiometabolic traits: the GLACIER Study . International Journal of Obesity vol. 40 , ( 9 ) 1346 - 1352 .

Qi L, Franks PW ( 2016 ) . Nutrigenetics of Type 2 Diabetes . The Genetics of Type 2 Diabetes and Related Traits , Springer Nature

Zanoni P, Khetarpal SA, Larach DB, Hancock-Cerutti WF, Millar JS, Cuchel M, DerOhannessian S, Kontush A et al. ( 2016 ) . Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease . Science vol. 351 , ( 6278 ) 1166 - 1171 .

Stitziel NO, Stirrups KE, Masca NGD, Erdmann J, Ferrario PG, König IR, Weeke PE, Webb TR et al. ( 2016 ) . Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease . The New England Journal of Medicine vol. 374 , ( 12 ) 1134 - 1144 .

( 2016 ) . Erratum: NIH Working Group Report—Using Genomic Information to Guide Weight Management: From Universal to Precision Treatment . Obesity vol. 24 , ( 3 ) 757 - 757 .

Ali A, Varga TV, Stojkovic IA, Schulz C-A, Hallmans G, Barroso I, Poveda A, Renström F et al. ( 2016 ) . Do Genetic Factors Modify the Relationship Between Obesity and Hypertriglyceridemia? . Circulation Genomic and Precision Medicine vol. 9 , ( 2 ) 162 - 171 .

Podmore C, Meidtner K, Schulze MB, Scott RA, Ramond A, Butterworth AS, Di Angelantonio E, Danesh J et al. ( 2016 ) . Association of Multiple Biomarkers of Iron Metabolism and Type 2 Diabetes: The EPIC-InterAct Study . Diabetes Care vol. 39 , ( 4 ) 572 - 581 .

Kilpeläinen TO, Carli JFM, Skowronski AA, Sun Q, Kriebel J, Feitosa MF, Hedman ÅK, Drong AW et al. ( 2016 ) . Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels . Nature Communications vol. 7 , ( 1 )

Clifton RG, Evans M, Cahill AG, Franks PW, Gallagher D, Phelan S, Pomeroy J, Redman LM et al. ( 2015 ) . Design of lifestyle intervention trials to prevent excessive gestational weight gain in women with overweight or obesity . Obesity vol. 24 , ( 2 ) 305 - 313 .

Bray MS, Loos RJ, McCaffery JM, Ling C, Franks PW, Weinstock GM, Snyder MP, Vassy JL et al. ( 2015 ) . NIH working group report—using genomic information to guide weight management: From universal to precision treatment . Obesity vol. 24 , ( 1 ) 14 - 22 .

Ahmad S, Zhao W, Renström F, Rasheed A, Samuel M, Zaidi M, Shah N, Mallick NH et al. ( 2015 ) . Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study . BMC Medical Genomics vol. 16 , ( 1 )

Gaulton KJ, Ferreira T, Lee Y, Raimondo A, Mägi R, Reschen ME, Mahajan A, Locke A et al. ( 2015 ) . Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci . Nature Genetics vol. 47 , ( 12 ) 1415 - 1425 .

Poveda A, Koivula RW, Ahmad S, Barroso I, Hallmans G, Johansson I, Renström F, Franks PW ( 2015 ) . Innate biology versus lifestyle behaviour in the aetiology of obesity and type 2 diabetes: the GLACIER Study . Diabetologia vol. 59 , ( 3 ) 462 - 471 .

Gaulton KJ, Ferreira T, Lee Y, Raimondo A, Mägi R, Reschen ME, Mahajan A, Locke A et al. ( 2015 ) . Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci . Nature Genetics vol. 47 , ( 12 ) 1415 - 1425 .

Hivert M-F, Christophi CA, Franks PW, Jablonski KA, Ehrmann DA, Kahn SE, Horton ES, Pollin TI et al. ( 2015 ) . Lifestyle and Metformin Ameliorate Insulin Sensitivity Independently of the Genetic Burden of Established Insulin Resistance Variants in Diabetes Prevention Program Participants . Diabetes vol. 65 , ( 2 ) 520 - 526 .

Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, Czajkowski J, Esko T et al. ( 2015 ) . The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study . PLOS Genetics vol. 11 , ( 10 )

van Nielen M, Feskens EJM, Mensink M, Sluijs I, Molina E, Amiano P, Ardanaz E, Balkau B et al. ( 2015 ) . Erratum. Dietary Protein Intake and Incidence of Type 2 Diabetes in Europe: The EPIC-InterAct Case-Cohort Study. Diabetes Care 2014;37:1854–1862 . Diabetes Care vol. 38 , ( 10 ) 1992 - 1992 .

Kato N, Loh M, Takeuchi F, Verweij N, Wang X, Zhang W, Kelly TN, Saleheen D et al. ( 2015 ) . Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation . Nature Genetics vol. 47 , ( 11 ) 1282 - 1293 .

Rukh G, Ahmad S, Ericson U, Hindy G, Stocks T, Renström F, Almgren P, Nilsson PM et al. ( 2015 ) . Inverse relationship between a genetic risk score of 31 BMI loci and weight change before and after reaching middle age . International Journal of Obesity vol. 40 , ( 2 ) 252 - 259 .

Fretts AM, Follis JL, Nettleton JA, Lemaitre RN, Ngwa JS, Wojczynski MK, Kalafati IP, Varga TV et al. ( 2015 ) . Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians 1 , 2 . American Journal of Clinical Nutrition vol. 102 , ( 5 ) 1266 - 1278 .

Brage S, Westgate K, Franks PW, Stegle O, Wright A, Ekelund U, Wareham NJ ( 2015 ) . Estimation of Free-Living Energy Expenditure by Heart Rate and Movement Sensing: A Doubly-Labelled Water Study . PLOS ONE vol. 10 , ( 9 )

Ahmad S, Zhao W, Renström F, Rasheed A, Zaidi M, Samuel M, Shah N, Mallick NH et al. ( 2015 ) . A novel interaction between the FLJ33534 locus and smoking in obesity: a genome-wide study of 14 131 Pakistani adults . International Journal of Obesity vol. 40 , ( 1 ) 186 - 190 .

Papandonatos GD, Pan Q, Pajewski NM, Delahanty LM, Peter I, Erar B, Ahmad S, Harden M et al. ( 2015 ) . Genetic Predisposition to Weight Loss and Regain With Lifestyle Intervention: Analyses From the Diabetes Prevention Program and the Look AHEAD Randomized Controlled Trials . Diabetes vol. 64 , ( 12 ) 4312 - 4321 .

Lunetta KL, Day FR, Sulem P, Ruth KS, Tung JY, Hinds DA, Esko T, Elks CE et al. ( 2015 ) . Rare coding variants and X-linked loci associated with age at menarche . Nature Communications vol. 6 , ( 1 )

Bennet L, Groop L, Franks PW ( 2015 ) . Country of birth modifies the association of fatty liver index with insulin action in Middle Eastern immigrants to Sweden . Diabetes Research and Clinical Practice vol. 110 , ( 1 ) 66 - 74 .

Brand JS, Onland-Moret NC, Eijkemans MJC, Tjønneland A, Roswall N, Overvad K, Fagherazzi G, Clavel-Chapelon F et al. ( 2015 ) . Diabetes and Onset of Natural Menopause . Obstetrical & Gynecological Survey vol. 70 , ( 8 ) 507 - 508 .

Rolandsson O, Hampe CS, Wennberg P, Radtke J, Langenberg C, Wareham N ( 2015 ) . Prevalence and Regional Distribution of Autoantibodies Against GAD65Ab in a European Population Without Diabetes: The EPIC-InterAct Study . Diabetes Care vol. 38 , ( 8 ) e114 - e115 .

Klüppelholz B, Thorand B, Koenig W, de las Heras Gala T, Meisinger C, Huth C, Giani G, Franks PW et al. ( 2015 ) . Association of subclinical inflammation with deterioration of glycaemia before the diagnosis of type 2 diabetes: the KORA S4/F4 study . Diabetologia vol. 58 , ( 10 ) 2269 - 2277 .

Østergaard SD, Mukherjee S, Sharp SJ, Proitsi P, Lotta LA, Day F, Perry JRB, Boehme KL et al. ( 2015 ) . Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study . PLOS Medicine vol. 12 , ( 6 )

Shungin D, Cornelis MC, Divaris K, Holtfreter B, Shaffer JR, Yu Y-H, Barros SP, Beck JD et al. ( 2015 ) . Using genetics to test the causal relationship of total adiposity and periodontitis: Mendelian randomization analyses in the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium . International Journal of Epidemiology vol. 44 , ( 2 ) 638 - 650 .

Cornelis MC, Byrne EM, Esko T, Nalls MA, Ganna A, Paynter N, Monda KL, Amin N et al. ( 2015 ) . Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption . Molecular Psychiatry vol. 20 , ( 5 ) 647 - 656 .

The InterAct Consortium ( 2015 ) . Dietary fibre and incidence of type 2 diabetes in eight European countries: the EPIC-InterAct Study and a meta-analysis of prospective studies . Diabetologia vol. 58 , ( 7 ) 1394 - 1408 .

Nettleton JA, Follis JL, Ngwa JS, Smith CE, Ahmad S, Tanaka T, Wojczynski MK, Voortman T et al. ( 2015 ) . Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry . Human Molecular Genetics vol. 24 , ( 16 ) 4728 - 4738 .

Dhurandhar NV, Schoeller DA, Brown AW, Heymsfield SB, Thomas D, Sørensen TIA, Speakman JR, Jeansonne M et al. ( 2015 ) . Response to ‘Energy balance measurement: when something is not better than nothing’ . International Journal of Obesity vol. 39 , ( 7 ) 1175 - 1176 .

Klüppelholz B, Thorand B, Koenig W, de las Heras Gala T, Meisinger C, Huth C, Giani G, Franks P et al. ( 2015 ) . Assoziationen zwischen Biomarkern der subklinischen Entzündung und HbA1c-Veränderungen vor der Diagnose des Typ-2-Diabetes: Ergebnisse aus der KORA S4/F4-Kohorte . Diabetologie und Stoffwechsel vol. 10 , ( S 01 )

Sluijs I, Holmes MV, van der Schouw YT, Beulens JWJ, Asselbergs FW, Huerta JM, Palmer TM, Arriola L et al. ( 2015 ) . A Mendelian Randomization Study of Circulating Uric Acid and Type 2 Diabetes . Diabetes vol. 64 , ( 8 ) 3028 - 3036 .

Jerant A, Bertakis KD, Franks P ( 2015 ) . Body mass index and health status in diabetic and non-diabetic individuals . Nutrition & Diabetes vol. 5 , ( 4 ) e152 - e152 .

Stijnen P, Tuand K, Varga TV, Franks PW, Aertgeerts B, Creemers JWM ( 2015 ) . The Authors Reply . American Journal of Epidemiology vol. 181 , ( 9 ) 733 - 734 .

Nelson CP, Hamby SE, Saleheen D, Hopewell JC, Zeng L, Assimes TL, Kanoni S, Willenborg C et al. ( 2015 ) . Genetically Determined Height and Coronary Artery Disease . The New England Journal of Medicine vol. 372 , ( 17 ) 1608 - 1618 .

Rockette-Wagner B, Edelstein S, Venditti EM, Reddy D, Bray GA, Carrion-Petersen ML, Dabelea D, Delahanty LM et al. ( 2015 ) . The impact of lifestyle intervention on sedentary time in individuals at high risk of diabetes . Diabetologia vol. 58 , ( 6 ) 1198 - 1202 .

Bennet L, Groop L, Franks P, Lindblad U, Arvidsson D, Nilsson PM ( 2015 ) . Dubbelt så hög risk för diabetes typ 2 hos svenskar födda i Irak . Lakartidningen vol. 112 , ( 16 ) 1 - 4 .

Rauh SP, Heymans MW, Alssema M, Nijpels G, Stehouwer CD, Thorand B, Rathmann W, Meisinger C et al. ( 2015 ) . PS7 - 3. Predicting Glycated Haemoglobin in the Non-Diabetic General Population: a DIRECT Study . Nederlands Tijdschrift voor Diabetologie vol. 11 , ( 4 ) 154 - 154 .

Sluik D, Buijsse B, Muckelbauer R, Kaaks R, Teucher B, Føns Johnsen N, Tjønneland A, Overvad K et al. ( 2015 ) . PS8 - 37. Physical Activity and Mortality in Individuals With Diabetes Mellitus: A Prospective Study and Meta-analysis . Nederlands Tijdschrift voor Diabetologie vol. 10 , ( 3 ) 123 - 124 .

Nead KT, Li A, Wehner MR, Neupane B, Gustafsson S, Butterworth A, Engert JC, Davis AD et al. ( 2015 ) . Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals . Human Molecular Genetics vol. 24 , ( 12 ) 3582 - 3594 .

Brand JS, Onland-Moret NC, Eijkemans MJC, Tjønneland A, Roswall N, Overvad K, Fagherazzi G, Clavel-Chapelon F et al. ( 2015 ) . Diabetes and onset of natural menopause: results from the European Prospective Investigation into Cancer and Nutrition . Human Reproduction vol. 30 , ( 6 ) 1491 - 1498 .

Renström F, Koivula RW, Varga TV, Hallmans G, Mulder H, Florez JC, Hu FB, Franks PW ( 2015 ) . Season-dependent associations of circadian rhythm-regulating loci (CRY1, CRY2 and MTNR1B) and glucose homeostasis: the GLACIER Study . Diabetologia vol. 58 , ( 5 ) 997 - 1005 .

Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S et al. ( 2015 ) . Genetic studies of body mass index yield new insights for obesity biology . Nature vol. 518 , ( 7538 ) 197 - 206 .

Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Mägi R, Strawbridge RJ, Pers TH et al. ( 2015 ) . New genetic loci link adipose and insulin biology to body fat distribution . Nature vol. 518 , ( 7538 ) 187 - 196 .

Wessel J, Chu AY, Willems SM, Wang S, Yaghootkar H, Brody JA, Dauriz M, Hivert M-F et al. ( 2015 ) . Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility . Nature Communications vol. 6 , ( 1 )

Mahajan A, Sim X, Ng HJ, Manning A, Rivas MA, Highland HM, Locke AE, Grarup N et al. ( 2015 ) . Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus . PLOS Genetics vol. 11 , ( 1 )

Estampador AC, Franks PW ( 2014 ) . Genetic and epigenetic catalysts in early-life programming of adult cardiometabolic disorders . Diabetes Metabolic Syndrome and Obesity vol. 7 , ( 0 ) 575 - 586 .

Buijsse B, Boeing H, Drogan D, Schulze MB, Feskens EJ, Amiano P, Barricarte A, Clavel-Chapelon F et al. ( 2014 ) . Consumption of fatty foods and incident type 2 diabetes in populations from eight European countries . European Journal of Clinical Nutrition vol. 69 , ( 4 ) 455 - 461 .

Scott RA, Fall T, Pasko D, Barker A, Sharp SJ, Arriola L, Balkau B, Barricarte A et al. ( 2014 ) . Common Genetic Variants Highlight the Role of Insulin Resistance and Body Fat Distribution in Type 2 Diabetes, Independent of Obesity . Diabetes vol. 63 , ( 12 ) 4378 - 4387 .

Consortium TI, Spijkerman AMW, van der A DL, Nilsson PM, Ardanaz E, Gavrila D, Agudo A, Arriola L et al. ( 2014 ) . Smoking and Long-Term Risk of Type 2 Diabetes: The EPIC-InterAct Study in European Populations . Diabetes Care vol. 37 , ( 12 ) 3164 - 3171 .

Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K et al. ( 2014 ) . Defining the role of common variation in the genomic and biological architecture of adult human height . Nature Genetics vol. 46 , ( 11 ) 1173 - 1186 .

Benyamin B, Esko T, Ried JS, Radhakrishnan A, Vermeulen SH, Traglia M, Gögele M, Anderson D et al. ( 2014 ) . Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis . Nature Communications vol. 5 , ( 1 )

Stijnen P, Tuand K, Varga TV, Franks PW, Aertgeerts B, Creemers JWM ( 2014 ) . The Association of Common Variants in PCSK1 With Obesity: A HuGE Review and Meta-Analysis . American Journal of Epidemiology vol. 180 , ( 11 ) 1051 - 1065 .

Cornelis MC, Byrne EM, Esko T, Nalls MA, Ganna A, Paynter N, Monda KL, Amin N et al. ( 2014 ) . Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption . Molecular Psychiatry

Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K et al. ( 2014 ) . Defining the role of common variation in the genomic and biological architecture of adult human height . Nature Genetics vol. 46 , ( 11 ) 1173 - 1186 .

Bennet L, Lindblad U, Franks PW ( 2014 ) . A family history of diabetes determines poorer glycaemic control and younger age of diabetes onset in immigrants from the Middle East compared with native Swedes . Diabetes & Metabolism vol. 41 , ( 1 ) 45 - 54 .

Kurbasic A, Poveda A, Chen Y, Ågren Å, Engberg E, Hu FB, Johansson I, Barroso I et al. ( 2014 ) . Gene-Lifestyle Interactions in Complex Diseases: Design and Description of the GLACIER and VIKING Studies . Current Nutrition Reports vol. 3 , ( 4 ) 400 - 411 .

Delahanty LM, Pan Q, Jablonski KA, Aroda VR, Watson KE, Bray GA, Kahn SE, Florez JC et al. ( 2014 ) . Effects of Weight Loss, Weight Cycling, and Weight Loss Maintenance on Diabetes Incidence and Change in Cardiometabolic Traits in the Diabetes Prevention Program . Diabetes Care vol. 37 , ( 10 ) 2738 - 2745 .

Kilpeläinen TO, Franks PW ( 2014 ) . Gene-Physical Activity Interactions and Their Impact on Diabetes . Diabetes and Physical Activity , vol. 60 , Karger Publishers

Tsoi H, Yu ACS, Chen ZS, Ng NKN, Chan AYY, Yuen LYP, Abrigo JM, Tsang SY et al. ( 2014 ) . A novel missense mutation in CCDC88C activates the JNK pathway and causes a dominant form of spinocerebellar ataxia . J Med Genet vol. 51 , ( 9 ) 590 - 595 .

Franks PW ( 2014 ) . Time to reappraise the use of body mass index in genetic association studies of children? . Obesity vol. 22 , ( 10 ) 2260 - 2261 .

Qi Q, Kilpeläinen TO, Downer MK, Tanaka T, Smith CE, Sluijs I, Sonestedt E, Chu AY et al. ( 2014 ) . FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals . Human Molecular Genetics vol. 23 , ( 25 ) 6961 - 6972 .

Forouhi NG, Koulman A, Sharp SJ, Imamura F, Kröger J, Schulze MB, Crowe FL, Huerta JM et al. ( 2014 ) . Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: the EPIC-InterAct case-cohort study . The Lancet Diabetes & Endocrinology vol. 2 , ( 10 ) 810 - 818 .

Goharian TS, Andersen LB, Franks PW, Wareham NJ, Brage S, Veidebaum T, Ekelund U, Lawlor DA et al. ( 2014 ) . Examining the causal association of fasting glucose with blood pressure in healthy children and adolescents: a Mendelian randomization study employing common genetic variants of fasting glucose . Journal of Human Hypertension vol. 29 , ( 3 ) 179 - 184 .

Hoggart CJ, Venturini G, Mangino M, Gomez F, Ascari G, Zhao JH, Teumer A, Winkler TW et al. ( 2014 ) . Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index . PLOS Genetics vol. 10 , ( 7 )

Tsoi H, Yu ACS, Chen ZS, Ng NKN, Chan AYY, Yuen LYP, Abrigo JM, Tsang SY et al. ( 2014 ) . A novel missense mutation in CCDC88C activates the JNK pathway and causes a dominant form of spinocerebellar ataxia . Journal of Medical Genetics vol. 51 , ( 9 )

Pembrey M, Saffery R, Bygren LO, Carstensen J, Edvinsson S, Faresjö T, Franks P, Gustafsson J-Å et al. ( 2014 ) . Human transgenerational responses to early-life experience: potential impact on development, health and biomedical research . Journal of Medical Genetics vol. 51 , ( 9 )

Perry JRB, Day F, Elks CE, Sulem P, Thompson DJ, Ferreira T, He C, Chasman DI et al. ( 2014 ) . Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche . Nature vol. 514 , ( 7520 ) 92 - 97 .

Jaacks LM, Ma Y, Davis N, Delahanty LM, Mayer‐Davis EJ, Franks PW, Brown‐Friday J, Isonaga M et al. ( 2014 ) . Long‐term changes in dietary and food intake behaviour in the Diabetes Prevention Program Outcomes Study . Diabetic Medicine vol. 31 , ( 12 ) 1631 - 1642 .

van Nielen M, Feskens EJM, Mensink M, Sluijs I, Molina E, Amiano P, Ardanaz E, Balkau B et al. ( 2014 ) . Dietary Protein Intake and Incidence of Type 2 Diabetes in Europe: The EPIC-InterAct Case-Cohort Study . Diabetes Care vol. 37 , ( 7 ) 1854 - 1862 .

Varga TV, Sonestedt E, Shungin D, Koivula RW, Hallmans G, Escher SA, Barroso I, Nilsson P et al. ( 2014 ) . Genetic Determinants of Long-Term Changes in Blood Lipid Concentrations: 10-Year Follow-Up of the GLACIER Study . PLOS Genetics vol. 10 , ( 6 )

Langenberg C, Sharp SJ, Franks PW, Scott RA, Deloukas P, Forouhi NG, Froguel P, Groop LC et al. ( 2014 ) . Gene-Lifestyle Interaction and Type 2 Diabetes: The EPIC InterAct Case-Cohort Study . PLOS Medicine vol. 11 , ( 5 )

Bennet L, Groop L, Franks PW ( 2014 ) . Ethnic differences in the contribution of insulin action and secretion to type 2 diabetes in immigrants from the Middle East compared to native Swedes . Diabetes Research and Clinical Practice vol. 105 , ( 1 ) 79 - 87 .

Winkler TW, Day FR, Croteau-Chonka DC, Wood AR, Locke AE, Mägi R, Ferreira T, Fall T et al. ( 2014 ) . Quality control and conduct of genome-wide association meta-analyses . Nature Protocols vol. 9 , ( 5 ) 1192 - 1212 .

Estampador AC, Pomeroy J, Renström F, Nelson SM, Mogren I, Persson M, Sattar N, Domellöf M et al. ( 2014 ) . Infant Body Composition and Adipokine Concentrations in Relation to Maternal Gestational Weight Gain . Diabetes Care vol. 37 , ( 5 ) 1432 - 1438 .

Dabelea D, Ma Y, Knowler WC, Marcovina S, Saudek CD, Arakaki R, White NH, Kahn SE et al. ( 2014 ) . Diabetes autoantibodies do not predict progression to diabetes in adults: the Diabetes Prevention Program . Diabetic Medicine vol. 31 , ( 9 ) 1064 - 1068 .

Koivula RW, Heggie A, Barnett A, Cederberg H, Hansen TH, Koopman AD, Ridderstråle M, Rutters F et al. ( 2014 ) . Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium . Diabetologia vol. 57 , ( 6 ) 1132 - 1142 .

Justice A, Winkler T, Ngwa J, Czajkowski J, Young K, Hadley D, Graf M, Chasman D et al. ( 2014 ) . Abstract 21: Accounting For Smoking Behavior In Genome-wide Analysis Of Obesity Phenotypes: The Giant (genetic Investigation Of Anthropometric Traits) Consortium . Circulation vol. 129 , ( suppl_1 )

Young KL, Hadley D, Justice A, Winkler T, Graff M, Ngwa J, Czajkowski J, Ahluwalia TS et al. ( 2014 ) . Abstract 22: Influence of Smoking and Sex on Genetic Associations of Body Fat Distribution: The Giant (Genetic Investigation of ANthropometric Traits) Consortium . Circulation vol. 129 , ( suppl_1 )

Graff M, Xue L, Kilpeläinen TO, Justice A, Winkler T, Young KL, Scott R, Qi Q et al. ( 2014 ) . Abstract 49: A Genome-wide Meta-analysis of the Combined Influence of Physical Activity and Genetic Variants on Body Fat Distribution in 94,779 Individuals of European Descent . Circulation vol. 129 , ( suppl_1 )

Del Gobbo LC, Aslibekyan S, Barberger-Gateau P, Campos H, Chiuve SE, Djoussé L, Franks P, Guallar E et al. ( 2014 ) . Abstract P357: Omega-3 Fatty Acid Biomarkers and Coronary Heart Disease: a Pooling Project of 17 Cohort Studies . Circulation vol. 129 , ( suppl_1 )

Golubic R, May AM, Borch KB, Overvad K, Charles M-A, Diaz MJT, Amiano P, Palli D et al. ( 2014 ) . Validity of Electronically Administered Recent Physical Activity Questionnaire (RPAQ) in Ten European Countries . PLOS ONE vol. 9 , ( 3 )

Sullivan SD, Jablonski KA, Florez JC, Dabelea D, Franks PW, Dagogo-Jack S, Kim C, Knowler WC et al. ( 2014 ) . Genetic Risk of Progression to Type 2 Diabetes and Response to Intensive Lifestyle or Metformin in Prediabetic Women With and Without a History of Gestational Diabetes Mellitus . Diabetes Care vol. 37 , ( 4 ) 909 - 911 .

Walford GA, Ma Y, Christophi CA, Goldberg RB, Jarolim P, Horton E, Mather KJ, Barrett-Connor E et al. ( 2014 ) . Circulating natriuretic peptide concentrations reflect changes in insulin sensitivity over time in the Diabetes Prevention Program . Diabetologia vol. 57 , ( 5 ) 935 - 939 .

Keildson S, Fadista J, Ladenvall C, Hedman ÅK, Elgzyri T, Small KS, Grundberg E, Nica AC et al. ( 2014 ) . Expression of Phosphofructokinase in Skeletal Muscle Is Influenced by Genetic Variation and Associated With Insulin Sensitivity . Diabetes vol. 63 , ( 3 ) 1154 - 1165 .

Venditti EM, Wylie-Rosett J, Delahanty LM, Mele L, Hoskin MA, Edelstein SL, for the Diabetes Prevention Program Research Group ( 2014 ) . Short and long-term lifestyle coaching approaches used to address diverse participant barriers to weight loss and physical activity adherence . International Journal of Behavioral Nutrition and Physical Activity vol. 11 , ( 1 )

Zhou K, Donnelly LA, Morris AD, Franks PW, Jennison C, Palmer CNA, Pearson ER ( 2014 ) . Clinical and Genetic Determinants of Progression of Type 2 Diabetes: A DIRECT Study . Diabetes Care vol. 37 , ( 3 ) 718 - 724 .

Billings LK, Jablonski KA, Ackerman RJ, Taylor A, Fanelli RR, McAteer JB, Guiducci C, Delahanty LM et al. ( 2014 ) . The Influence of Rare Genetic Variation in SLC30A8 on Diabetes Incidence and β-Cell Function . The Journal of Clinical Endocrinology & Metabolism vol. 99 , ( 5 ) e926 - e930 .

Bennet L, Groop L, Lindblad U, Agardh C-D, Franks PW ( 2014 ) . Ethnicity is an independent risk indicator when estimating diabetes risk with FINDRISC scores: A cross sectional study comparing immigrants from the Middle East and native Swedes . Primary Care Diabetes vol. 8 , ( 3 ) 231 - 238 .

Kilpeläinen TO, Franks PW ( 2014 ) . Gene-physical activity interactions and their impact on diabetes . Medicine and Sport Science vol. 60 , 94 - 103 .

Zamora-Ros R, Forouhi NG, Sharp SJ, González CA, Buijsse B, Guevara M, van der Schouw YT, Amiano P et al. ( 2013 ) . Dietary Intakes of Individual Flavanols and Flavonols Are Inversely Associated with Incident Type 2 Diabetes in European Populations 1–3 . Journal of Nutrition vol. 144 , ( 3 ) 335 - 343 .

Franks PW, Christophi CA, Jablonski KA, Billings LK, Delahanty LM, Horton ES, Knowler WC, Florez JC et al. ( 2013 ) . Common variation at PPARGC1A/B and change in body composition and metabolic traits following preventive interventions: the Diabetes Prevention Program . Diabetologia vol. 57 , ( 3 ) 485 - 490 .

Abbas S, Linseisen J, Rohrmann S, Beulens JWJ, Buijsse B, Amiano P, Ardanaz E, Balkau B et al. ( 2013 ) . Dietary vitamin D intake and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition: the EPIC-InterAct study . European Journal of Clinical Nutrition vol. 68 , ( 2 ) 196 - 202 .

Svensson Å, Renström F, Bluck L, Lissner L, Franks PW, Larsson C ( 2013 ) . Dietary intake assessment in women with different weight and pregnancy status using a short questionnaire . Public Health Nutrition vol. 17 , ( 9 ) 1939 - 1948 .

Zamora-Ros R, Forouhi NG, Sharp SJ, González CA, Buijsse B, Guevara M, van der Schouw YT, Amiano P et al. ( 2013 ) . The Association Between Dietary Flavonoid and Lignan Intakes and Incident Type 2 Diabetes in European Populations The EPIC-InterAct study . Diabetes Care vol. 36 , ( 12 ) 3961 - 3970 .

The InterAct Consortium ( 2013 ) . Adherence to predefined dietary patterns and incident type 2 diabetes in European populations: EPIC-InterAct Study . Diabetologia vol. 57 , ( 2 ) 321 - 333 .

Do R, Willer CJ, Schmidt EM, Sengupta S, Gao C, Peloso GM, Gustafsson S, Kanoni S et al. ( 2013 ) . Common variants associated with plasma triglycerides and risk for coronary artery disease . Nature Genetics vol. 45 , ( 11 ) 1345 - 1353 .

Global Lipids Genetics Consortium, Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, Ganna A et al. ( 2013 ) . Discovery and refinement of loci associated with lipid levels . Nat Genet vol. 45 , ( 11 ) 1274 - 1283 .

Davis NJ, Ma Y, Delahanty LM, Hoffman HJ, Mayer-Davis E, Franks PW, Brown-Friday J, Isonaga M et al. ( 2013 ) . Predictors of Sustained Reduction in Energy and Fat Intake in the Diabetes Prevention Program Outcomes Study Intensive Lifestyle Intervention . Journal of the Academy of Nutrition and Dietetics vol. 113 , ( 11 ) 1455 - 1464 .

Sluik D, Boeing H, Li K, Kaaks R, Johnsen NF, Tjønneland A, Arriola L, Barricarte A et al. ( 2013 ) . Lifestyle factors and mortality risk in individuals with diabetes mellitus: are the associations different from those in individuals without diabetes? . Diabetologia vol. 57 , ( 1 ) 63 - 72 .

Elks CE, Ong KK, Scott RA, van der Schouw YT, Brand JS, Wark PA, Amiano P, Balkau B et al. ( 2013 ) . Age at Menarche and Type 2 Diabetes Risk . Diabetes Care vol. 36 , ( 11 ) 3526 - 3534 .

Kengne AP, Beulens JW, Peelen LM, Moons KG, van der Schouw YT, Schulze MB, Spijkerman AM, Griffin SJ et al. ( 2013 ) . Non-invasive risk scores for prediction of type 2 diabetes (EPIC-InterAct): a validation of existing models . The Lancet Diabetes & Endocrinology vol. 2 , ( 1 ) 19 - 29 .

Do R, Willer CJ, Schmidt EM, Sengupta S, Gao C, Peloso GM, Gustafsson S, Kanoni S et al. ( 2013 ) . Common variants associated with plasma triglycerides and risk for coronary artery disease . Nature Genetics vol. 45 , ( 11 ) 1345 - 1352 .

Ahmad S, Varga TV, Franks PW ( 2013 ) . Gene × Environment Interactions in Obesity: The State of the Evidence . Human Heredity vol. 75 , ( 2-4 ) 106 - 115 .

Franks PW ( 2013 ) . Body Weight and Risk of Early Death . Obesity vol. 21 , ( 9 ) 1743 - 1743 .

Wientzek A, Díaz MT, Castaño JMH, Amiano P, Arriola L, Overvad K, Østergaard JN, Charles M et al. ( 2013 ) . Cross‐sectional associations of objectively measured physical activity, cardiorespiratory fitness and anthropometry in European adults . Obesity vol. 22 , ( 5 ) e127 - e134 .

Hivert M-F, Bouchard L, Franks PW ( 2013 ) . Maternal Nutrition and Epigenetics in Early Life . Current Nutrition Reports vol. 2 , ( 4 ) 216 - 224 .

Ahmad S, Rukh G, Varga TV, Ali A, Kurbasic A, Shungin D, Ericson U, Koivula RW et al. ( 2013 ) . Gene × Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry . PLOS Genetics vol. 9 , ( 7 )

Hu Y-J, Berndt SI, Gustafsson S, Ganna A, Consortium GIOAT, Berndt SI, Gustafsson S, Mägi R et al. ( 2013 ) . Meta-analysis of Gene-Level Associations for Rare Variants Based on Single-Variant Statistics . American Journal of Human Genetics vol. 93 , ( 2 ) 236 - 248 .

Franks PW, Looker HC ( 2013 ) . Gene–physical activity interactions and their role in determining cardiovascular and metabolic health . Paediatric Exercise Science and Medicine , Oxford University Press (OUP)

Pan Q, Delahanty LM, Jablonski KA, Knowler WC, Kahn SE, Florez JC, Franks PW, Group DPPR ( 2013 ) . Variation at the melanocortin 4 receptor gene and response to weight‐loss interventions in the diabetes prevention program . Obesity vol. 21 , ( 9 ) e520 - e526 .

Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, Kilpeläinen TO, Esko T et al. ( 2013 ) . Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits . PLOS Genetics vol. 9 , ( 6 )

Varga TV, Hallmans G, Hu FB, Renström F, Franks PW ( 2013 ) . Smoking Status, Snus Use, and Variation at the CHRNA5-CHRNA3-CHRNB4 Locus in Relation to Obesity: The GLACIER Study . American Journal of Epidemiology vol. 178 , ( 1 ) 31 - 37 .

van den Berg SW, van der A DL, Spijkerman AMW, van Woudenbergh GJ, Tijhuis MJ, Amiano P, Ardanaz E, Beulens JWJ et al. ( 2013 ) . The Association between Dietary Energy Density and Type 2 Diabetes in Europe: Results from the EPIC-InterAct Study . PLOS ONE vol. 8 , ( 5 )

Tanaka T, Ngwa JS, van Rooij FJA, Zillikens MC, Wojczynski MK, Frazier-Wood AC, Houston DK, Kanoni S et al. ( 2013 ) . Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake 1 , 2 , 3 , 4 . American Journal of Clinical Nutrition vol. 97 , ( 6 ) 1395 - 1402 .

The InterAct consortium ( 2013 ) . Consumption of sweet beverages and type 2 diabetes incidence in European adults: results from EPIC-InterAct . Diabetologia vol. 56 , ( 7 ) 1520 - 1530 .

Franks PW, Christophi CA, Jablonski KA, Delahanty LM, Horton ES, Knowler WC, Florez JC, on behalf of the Diabetes Prevention Program Research Group ( 2013 ) . RETRACTED ARTICLE: Common variation in PPARGC1A/B and progression to diabetes or change in metabolic traits following preventive interventions: the Diabetes Prevention Program . Diabetologia vol. 56 , ( 9 ) 2102 - 2102 .

van Hees VT, Gorzelniak L, León ECD, Eder M, Pias M, Taherian S, Ekelund U, Renström F et al. ( 2013 ) . Separating Movement and Gravity Components in an Acceleration Signal and Implications for the Assessment of Human Daily Physical Activity . PLOS ONE vol. 8 , ( 4 )

Franks PW, Pearson E, Florez JC ( 2013 ) . Gene-Environment and Gene-Treatment Interactions in Type 2 Diabetes . Diabetes Care vol. 36 , ( 5 ) 1413 - 1421 .

Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL et al. ( 2013 ) . Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture . Nature Genetics vol. 45 , ( 5 ) 501 - 512 .

Brand JS, van der Schouw YT, Onland-Moret NC, Sharp SJ, Ong KK, Khaw K-T, Ardanaz E, Amiano P et al. ( 2013 ) . Age at Menopause, Reproductive Life Span, and Type 2 Diabetes Risk Results from the EPIC-InterAct study . Diabetes Care vol. 36 , ( 4 ) 1012 - 1019 .

Koivula RW, Tornberg ÅB, Franks PW ( 2013 ) . Exercise and Diabetes-Related Cardiovascular Disease: Systematic Review of Published Evidence from Observational Studies and Clinical Trials . Current Diabetes Reports vol. 13 , ( 3 ) 372 - 380 .

Hruby A, Ngwa JS, Renström F, Wojczynski MK, Ganna A, Hallmans G, Houston DK, Jacques PF et al. ( 2013 ) . Higher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium Studies . Journal of Nutrition vol. 143 , ( 3 ) 345 - 353 .

Pomeroy J, Renström F, Gradmark AM, Mogren I, Persson M, Bluck L, Wright A, Kahn SE et al. ( 2013 ) . Maternal Physical Activity and Insulin Action in Pregnancy and Their Relationships With Infant Body Composition . Diabetes Care vol. 36 , ( 2 ) 267 - 269 .

Nettleton JA, Hivert M-F, Lemaitre RN, McKeown NM, Mozaffarian D, Tanaka T, Wojczynski MK, Hruby A et al. ( 2012 ) . Meta-Analysis Investigating Associations Between Healthy Diet and Fasting Glucose and Insulin Levels and Modification by Loci Associated With Glucose Homeostasis in Data From 15 Cohorts . American Journal of Epidemiology vol. 177 , ( 2 ) 103 - 115 .

Group TDPPOSRGPOBOTDR, Orchard TJ, Temprosa M, Barrett‐Connor E, Fowler SE, Goldberg RB, Mather KJ, Marcovina SM et al. ( 2012 ) . Long‐term effects of the Diabetes Prevention Program interventions on cardiovascular risk factors: a report from the DPP Outcomes Study . Diabetic Medicine vol. 30 , ( 1 ) 46 - 55 .

Deloukas P, Kanoni S, Willenborg C, Farrall M, Assimes TL, Thompson JR, Ingelsson E, Saleheen D et al. ( 2012 ) . Large-scale association analysis identifies new risk loci for coronary artery disease . Nature Genetics vol. 45 , ( 1 ) 25 - 33 .

Albrechtsen A, Grarup N, Li Y, Sparsø T, Tian G, Cao H, Jiang T, Kim SY et al. ( 2012 ) . Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes . Diabetologia vol. 56 , ( 2 ) 298 - 310 .

Mather KJ, Christophi CA, Jablonski KA, Knowler WC, Goldberg RB, Kahn SE, Spector T, Dastani Z et al. ( 2012 ) . Common variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/2), adiponectin concentrations, and diabetes incidence in the Diabetes Prevention Program . Diabetic Medicine vol. 29 , ( 12 ) 1579 - 1588 .

Wiklund P, Nordström A, Högström M, Alfredson H, Engström P, Gustafsson T, Franks PW, Nordström P ( 2012 ) . High‐impact loading on the skeleton is associated with a decrease in glucose levels in young men . Clinical Endocrinology vol. 77 , ( 6 ) 823 - 827 .

Christophi CA, Resnick HE, Ratner RE, Temprosa M, Fowler S, Knowler WC, Shamoon H, Barrett-Connor E et al. ( 2012 ) . Confirming Glycemic Status in the Diabetes Prevention Program: Implications for Diagnosing Diabetes in High Risk Adults . Journal of Diabetes and its Complications vol. 27 , ( 2 ) 150 - 157 .

Franks PW ( 2012 ) . The Complex Interplay of Genetic and Lifestyle Risk Factors in Type 2 Diabetes: An Overview . Scientifica vol. 2012 , ( 1 )

The InterAct Consortium ( 2012 ) . The link between family history and risk of type 2 diabetes is not explained by anthropometric, lifestyle or genetic risk factors: the EPIC-InterAct study . Diabetologia vol. 56 , ( 1 ) 60 - 69 .

Ahmad S, Heraclides A, Sun Q, Elgzyri T, Rönn T, Ling C, Isomaa B, Eriksson K et al. ( 2012 ) . Telomere length in blood and skeletal muscle in relation to measures of glycaemia and insulinaemia . Diabetic Medicine vol. 29 , ( 10 ) e377 - e381 .

The InterAct Consortium ( 2012 ) . Association between dietary meat consumption and incident type 2 diabetes: the EPIC-InterAct study . Diabetologia vol. 56 , ( 1 ) 47 - 59 .

Florez JC, Jablonski KA, McAteer JB, Franks PW, Mason CC, Mather K, Horton E, Goldberg R et al. ( 2012 ) . Effects of Genetic Variants Previously Associated with Fasting Glucose and Insulin in the Diabetes Prevention Program . PLOS ONE vol. 7 , ( 9 )

Vimaleswaran KS, Franks PW, Brage S, Sardinha LB, Andersen LB, Wareham NJ, Ekelund U, Loos RJF ( 2012 ) . Absence of Association Between the INSIG2 Gene Polymorphism (rs7566605) and Obesity in the European Youth Heart Study (EYHS) . Obesity vol. 17 , ( 7 ) 1453 - 1457 .

Vimaleswaran KS, Franks PW, Brage S, Grontved A, Wareham NJ, Ekelund U, Loos RJF ( 2012 ) . Lack of Association Between PCK1 Polymorphisms and Obesity, Physical Activity, and Fitness in European Youth Heart Study (EYHS) . Obesity vol. 18 , ( 10 ) 1975 - 1980 .

Franks PW, Brage S, Luan J, Ekelund U, Rahman M, Farooqi IS, Halsall I, O'Rahilly S et al. ( 2012 ) . Leptin Predicts a Worsening of the Features of the Metabolic Syndrome Independently of Obesity . Obesity vol. 13 , ( 8 ) 1476 - 1484 .

Ekelund U, Franks PW, Wareham NJ, Åman J ( 2012 ) . Oxygen Uptakes Adjusted for Body Composition in Normal‐Weight and Obese Adolescents . Obesity vol. 12 , ( 3 ) 513 - 520 .

Guo Y, Ma L, Enriori PJ, Koska J, Franks PW, Brookshire T, Cowley MA, Salbe AD et al. ( 2012 ) . Physiological Evidence for the Involvement of Peptide YY in the Regulation of Energy Homeostasis in Humans . Obesity vol. 14 , ( 9 ) 1562 - 1570 .

Guo Y, Franks PW, Brookshire T, Tataranni PA ( 2012 ) . The Intra‐ and Inter‐instrument Reliability of DXA Based on Ex Vivo Soft Tissue Measurements . Obesity vol. 12 , ( 12 ) 1925 - 1929 .

Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, MäGi R, Strawbridge RJ et al. ( 2012 ) . Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways . Nature Genetics vol. 44 , ( 9 ) 991 - 1005 .

Pollin TI, Isakova T, Jablonski KA, de Bakker PIW, Taylor A, McAteer J, Pan Q, Horton ES et al. ( 2012 ) . Genetic Modulation of Lipid Profiles following Lifestyle Modification or Metformin Treatment: The Diabetes Prevention Program . PLOS Genetics vol. 8 , ( 8 )

Florez JC, Jablonski KA, Taylor A, Mather K, Horton E, White NH, Barrett-Connor E, Knowler WC et al. ( 2012 ) . The C Allele of ATM rs11212617 Does Not Associate With Metformin Response in the Diabetes Prevention Program . Diabetes Care vol. 35 , ( 9 ) 1864 - 1867 .

Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, Mägi R, Strawbridge RJ et al. ( 2012 ) . Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways . Nature Genetics vol. 44 , ( 9 ) 991 - 1005 .

Franks PW ( 2012 ) . Genetic risk scores ascertained in early adulthood and the prediction of type 2 diabetes later in life . Diabetologia vol. 55 , ( 10 ) 2555 - 2558 .

Cooper AJ, Forouhi NG, Ye Z, Buijsse B, Arriola L, Balkau B, Barricarte A, Beulens JWJ et al. ( 2012 ) . Fruit and vegetable intake and type 2 diabetes: EPIC-InterAct prospective study and meta-analysis . European Journal of Clinical Nutrition vol. 66 , ( 10 ) 1082 - 1092 .

Sluijs I, Forouhi NG, Beulens JW, van der Schouw YT, Agnoli C, Arriola L, Balkau B, Barricarte A et al. ( 2012 ) . The amount and type of dairy product intake and incident type 2 diabetes: results from the EPIC-InterAct Study . American Journal of Clinical Nutrition vol. 96 , ( 2 ) 382 - 390 .

Sluik D, Boeing H, Montonen J, Kaaks R, Lukanova A, Sandbaek A, Overvad K, Arriola L et al. ( 2012 ) . HbA1c Measured in Stored Erythrocytes Is Positively Linearly Associated with Mortality in Individuals with Diabetes Mellitus . PLOS ONE vol. 7 , ( 6 )

Nordström P, Franks PW, Gustafson Y, Nordström A ( 2012 ) . Cognitive function in young men and the later risk of fractures . Journal of Bone and Mineral Research vol. 27 , ( 11 ) 2291 - 2297 .

Langenberg C, Sharp SJ, Schulze MB, Rolandsson O, Overvad K, Forouhi NG, Spranger J, Drogan D et al. ( 2012 ) . Long-Term Risk of Incident Type 2 Diabetes and Measures of Overall and Regional Obesity: The EPIC-InterAct Case-Cohort Study . PLOS Medicine vol. 9 , ( 6 )

Sun Q, Shi L, Prescott J, Chiuve SE, Hu FB, De Vivo I, Stampfer MJ, Franks PW et al. ( 2012 ) . Healthy Lifestyle and Leukocyte Telomere Length in U.S. Women . PLOS ONE vol. 7 , ( 5 )

van Woudenbergh GJ, Kuijsten A, Drogan D, van der A DL, Romaguera D, Ardanaz E, Amiano P, Barricarte A et al. ( 2012 ) . Tea Consumption and Incidence of Type 2 Diabetes in Europe: The EPIC-InterAct Case-Cohort Study . PLOS ONE vol. 7 , ( 5 )

Manning AK, Hivert M-F, Scott RA, Grimsby JL, Bouatia-Naji N, Chen H, Rybin D, Liu C-T et al. ( 2012 ) . A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance . Nature Genetics vol. 44 , ( 6 ) 659 - 669 .

Fox CS, Liu Y, White CC, Feitosa M, Smith AV, Heard-Costa N, Lohman K, Johnson AD et al. ( 2012 ) . Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women . PLOS Genetics vol. 8 , ( 5 )

Patel PS, Forouhi NG, Kuijsten A, Schulze MB, van Woudenbergh GJ, Ardanaz E, Amiano P, Arriola L et al. ( 2012 ) . The prospective association between total and type of fish intake and type 2 diabetes in 8 European countries: EPIC-InterAct Study . American Journal of Clinical Nutrition vol. 95 , ( 6 ) 1445 - 1453 .

Beulens JWJ, van der Schouw YT, Bergmann MM, Rohrmann S, Schulze MB, Buijsse B, Grobbee DE, Arriola L et al. ( 2012 ) . Alcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body sizeThe EPIC–InterAct study . Journal of Internal Medicine vol. 272 , ( 4 ) 358 - 370 .

Nordström⁎ P, Franks PW, Gustafson Y, Nordström A ( 2012 ) . Cognitive performance in young adulthood and the risk of fractures later in life . Bone vol. 50 ,

Elgzyri T, Parikh H, Zhou Y, Nitert MD, Rönn T, Segerström ÅB, Ling C, Franks PW et al. ( 2012 ) . First-Degree Relatives of Type 2 Diabetic Patients Have Reduced Expression of Genes Involved in Fatty Acid Metabolism in Skeletal Muscle . The Journal of Clinical Endocrinology & Metabolism vol. 97 , ( 7 ) e1332 - e1337 .

The InterAct Consortium ( 2012 ) . Physical activity reduces the risk of incident type 2 diabetes in general and in abdominally lean and obese men and women: the EPIC–InterAct Study . Diabetologia vol. 55 , ( 7 ) 1944 - 1952 .

Scott RA, Chu AY, Grarup N, Manning AK, Hivert M-F, Shungin D, Tönjes A, Yesupriya A et al. ( 2012 ) . No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels . Diabetes vol. 61 , ( 5 ) 1291 - 1296 .

Dastani Z, Hivert M-F, Timpson N, Perry JRB, Yuan X, Scott RA, Henneman P, Heid IM et al. ( 2012 ) . Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals . PLOS Genetics vol. 8 , ( 3 )

Sarwar N, Butterworth AS, Freitag DF, Gregson J, Willeit P, Gorman DN, Gao P, Saleheen D et al. ( 2012 ) . Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies . The Lancet vol. 379 , ( 9822 ) 1205 - 1213 .

Nettleton JA, Hivert M-F, McKeown NM, Mozaffarian D, Tanaka T, Wojczynski MK, Hruby A, Djousse L et al. ( 2012 ) . Abstract 010: Favorable Associations of a Healthy Diet with Fasting Glucose or Insulin are Not Modified by Fasting Glucose- or Insulin-Associated Genotypes in 51,289 Non-Diabetic Individuals from 15 Cohorts . Circulation vol. 125 , ( suppl_10 )

Group* TDPPR ( 2012 ) . Long-Term Safety, Tolerability, and Weight Loss Associated With Metformin in the Diabetes Prevention Program Outcomes Study . Diabetes Care vol. 35 , ( 4 ) 731 - 737 .

Delahanty LM, Pan Q, Jablonski KA, Watson KE, McCaffery JM, Shuldiner A, Kahn SE, Knowler WC et al. ( 2012 ) . Genetic Predictors of Weight Loss and Weight Regain After Intensive Lifestyle Modification, Metformin Treatment, or Standard Care in the Diabetes Prevention Program . Diabetes Care vol. 35 , ( 2 ) 363 - 366 .

Palmer ND, McDonough CW, Hicks PJ, Roh BH, Wing MR, An SS, Hester JM, Cooke JN et al. ( 2012 ) . A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans . PLOS ONE vol. 7 , ( 1 )

Sluik D, Boeing H, Bergmann MM, Schutze M, Teucher B, Kaaks R, Tjonneland A, Overvad K et al. ( 2012 ) . Alcohol consumption and mortality in individuals with diabetes mellitus . The British Journal of Nutrition: an international journal of nutritional science vol. 108 , ( 7 ) 1307 - 1315 .

Sacerdote C, Ricceri F, Rolandsson O, Baldi I, Chirlaque MD, Feskens E, Bendinelli B, Ardanaz E et al. ( 2012 ) . Lower educational level is a predictor of incident type 2 diabetes in European countries: the EPIC-InterAct study . Int J Epidemiol vol. 41 , ( 4 ) 1162 - 1173 .

Sluik D, Buijsse B, Muckelbauer R, Kaaks R, Teucher B, Johnsen NF, Tjonneland A, Overvad K et al. ( 2012 ) . Physical Activity and Mortality in Individuals With Diabetes Mellitus: A Prospective Study and Meta-analysis . Arch Intern Med vol. 172 , ( 17 ) 1285 - 1295 .

The InterAct Consortium ( 2011 ) . Validity of a short questionnaire to assess physical activity in 10 European countries . European Journal of Epidemiology vol. 27 , ( 1 ) 15 - 25 .

Kilpeläinen TO, Qi L, Brage S, Sharp SJ, Sonestedt E, Demerath E, Ahmad T, Mora S et al. ( 2011 ) . Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children . PLOS Medicine vol. 8 , ( 11 )

Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S et al. ( 2011 ) . Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma . Nature Genetics vol. 43 , ( 11 ) 1131 - 1138 .

Franks PW ( 2011 ) . Gene × Environment Interactions in Type 2 Diabetes . Current Diabetes Reports vol. 11 , ( 6 )

Ma L, Mondal AK, Murea M, Sharma NK, Tönjes A, Langberg KA, Das SK, Franks PW et al. ( 2011 ) . The Effect of ACACB cis-Variants on Gene Expression and Metabolic Traits . PLOS ONE vol. 6 , ( 8 )

Kanoni S, Nettleton JA, Hivert M-F, Ye Z, van Rooij FJA, Shungin D, Sonestedt E, Ngwa JS et al. ( 2011 ) . Total Zinc Intake May Modify the Glucose-Raising Effect of a Zinc Transporter (SLC30A8) Variant A 14-Cohort Meta-analysis . Diabetes vol. 60 , ( 9 ) 2407 - 2416 .

Romaguera D, Guevara M, Norat T, Langenberg C, Forouhi NG, Sharp S, Slimani N, Schulze MB et al. ( 2011 ) . Mediterranean Diet and Type 2 Diabetes Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC) Study The InterAct project . Diabetes Care vol. 34 , ( 9 ) 1913 - 1918 .

van Hees VT, Renström F, Wright A, Gradmark A, Catt M, Chen KY, Löf M, Bluck L et al. ( 2011 ) . Estimation of Daily Energy Expenditure in Pregnant and Non-Pregnant Women Using a Wrist-Worn Tri-Axial Accelerometer . PLOS ONE vol. 6 , ( 7 )

McCaffery JM, Jablonski KA, Franks PW, Dagogo-Jack S, Wing RR, Knowler WC, Delahanty L, Dabelea D et al. ( 2011 ) . TCF7L2 Polymorphism, Weight Loss and Proinsulin∶Insulin Ratio in the Diabetes Prevention Program . PLOS ONE vol. 6 , ( 7 )

Franks PW, Poveda A ( 2011 ) . Gene-lifestyle and gene-pharmacotherapy interactions in obesity and its cardiovascular consequences . Current Vascular Pharmacology vol. 9 , ( 4 ) 401 - 456 .

The InterAct Consortium ( 2011 ) . Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study . Diabetologia vol. 54 , ( 9 )

Gradmark A, Pomeroy J, Renström F, Steiginga S, Persson M, Wright A, Bluck L, Domellöf M et al. ( 2011 ) . Physical activity, sedentary behaviors, and estimated insulin sensitivity and secretion in pregnant and non-pregnant women . BMC Pregnancy and Childbirth vol. 11 , ( 1 )

Grøntved A, Steene-Johannessen J, Kynde I, Franks PW, Helge JW, Froberg K, Anderssen SA, Andersen LB ( 2011 ) . Association between plasma leptin and blood pressure in two population-based samples of children and adolescents . Journal of Hypertension vol. 29 , ( 6 ) 1093 - 1100 .

Sluik D, Boeing H, Montonen J, Pischon T, Kaaks R, Teucher B, Tjønneland A, Halkjaer J et al. ( 2011 ) . Associations Between General and Abdominal Adiposity and Mortality in Individuals With Diabetes Mellitus . American Journal of Epidemiology vol. 174 , ( 1 ) 22 - 34 .

Vassy JL, Shrader P, Jonsson A, Fox CS, Lyssenko V, Isomaa B, Groop L, Meigs JB et al. ( 2011 ) . Association between parental history of diabetes and type 2 diabetes genetic risk scores in the PPP-Botnia and Framingham Offspring Studies . Diabetes Research and Clinical Practice vol. 93 , ( 2 ) e76 - e79 .

Franks PW, Shungin D ( 2011 ) . The interplay of lifestyle and genetic susceptibility in Type 2 diabetes risk . Diabetes Management vol. 1 , ( 3 ) 299 - 307 .

Pomeroy J, Brage S, Curtis JM, Swan PD, Knowler WC, Franks PW ( 2011 ) . Between-Monitor Differences in Step Counts Are Related to Body Size: Implications for Objective Physical Activity Measurement . PLOS ONE vol. 6 , ( 4 )

Hivert M-F, Jablonski KA, Perreault L, Saxena R, McAteer JB, Franks PW, Hamman RF, Kahn SE et al. ( 2011 ) . Updated Genetic Score Based on 34 Confirmed Type 2 Diabetes Loci Is Associated With Diabetes Incidence and Regression to Normoglycemia in the Diabetes Prevention Program . Diabetes vol. 60 , ( 4 ) 1340 - 1348 .

Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, Gudnason V, Eiriksdottir G et al. ( 2011 ) . Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits . PLOS Genetics vol. 7 , ( 3 )

Nöthlings U, Boeing H, Maskarinec G, Sluik D, Teucher B, Kaaks R, Tjønneland A, Halkjaer J et al. ( 2011 ) . Food intake of individuals with and without diabetes across different countries and ethnic groups . European Journal of Clinical Nutrition vol. 65 , ( 5 ) 635 - 641 .

Toss F, Wiklund P, Franks PW, Eriksson M, Gustafson Y, Hallmans G, Nordström P, Nordström A ( 2011 ) . Abdominal and gynoid adiposity and the risk of stroke . International Journal of Obesity vol. 35 , ( 11 ) 1427 - 1432 .

( 2011 ) . Erratum . Diabetes Care vol. 34 , ( 3 ) 785 - 786 .

Franks PW, Brito EC ( 2011 ) . Interaction Between Exercise and Genetics in Type 2 Diabetes Mellitus: An Epidemiological Perspective . Exercise Genomics , Springer Nature

Grøntved A, Andersen LB, Franks PW, Verhage B, Wareham NJ, Ekelund U, Loos RJF, Brage S ( 2011 ) . NOS3 Variants, Physical Activity, and Blood Pressure in the European Youth Heart Study . American Journal of Hypertension vol. 24 , ( 4 ) 444 - 450 .

Johnson ST, Newton AS, Chopra M, Buckingham J, Huang TT, Franks PW, Jetha MM, Ball GD ( 2010 ) . In search of quality evidence for lifestyle management and glycemic control in children and adolescents with type 2 diabetes: A systematic review . BMC Pediatrics vol. 10 , ( 1 )

Franks PW, Ling C ( 2010 ) . Epigenetics and obesity: the devil is in the details . BMC Medicine vol. 8 , ( 1 )

Almqvist C, Adami H-O, Franks PW, Groop L, Ingelsson E, Kere J, Lissner L, Litton J-E et al. ( 2010 ) . LifeGene—a large prospective population-based study of global relevance . European Journal of Epidemiology vol. 26 , ( 1 ) 67 - 77 .

Franks PW ( 2010 ) . Diabetes Family History: A Metabolic Storm You Should Not Sit Out . Diabetes vol. 59 , ( 11 ) 2732 - 2734 .

Renström F, Shungin D, Johansson I, Florez JC, Hallmans G, Hu FB, Franks PW ( 2010 ) . Genetic Predisposition to Long-Term Nondiabetic Deteriorations in Glucose Homeostasis Ten-Year Follow-Up of the GLACIER Study . Diabetes vol. 60 , ( 1 ) 345 - 354 .

Franks PW, Nettleton JA ( 2010 ) . Invited Commentary: Gene × Lifestyle Interactions and Complex Disease Traits—Inferring Cause and Effect From Observational Data, Sine Qua Non . American Journal of Epidemiology vol. 172 , ( 9 ) 992 - 997 .

Ma L, Hanson RL, Traurig MT, Muller YL, Kaur BP, Perez JM, Meyre D, Fu M et al. ( 2010 ) . Evaluation of A2BP1 as an Obesity Gene . Diabetes vol. 59 , ( 11 ) 2837 - 2845 .

Nettleton JA, McKeown NM, Kanoni S, Lemaitre RN, Hivert M-F, Ngwa J, van Rooij FJA, Sonestedt E et al. ( 2010 ) . Interactions of Dietary Whole-Grain Intake With Fasting Glucose– and Insulin-Related Genetic Loci in Individuals of European Descent A meta-analysis of 14 cohort studies . Diabetes Care vol. 33 , ( 12 ) 2684 - 2691 .

Jablonski KA, McAteer JB, de Bakker PIW, Franks PW, Pollin TI, Hanson RL, Saxena R, Fowler S et al. ( 2010 ) . Common Variants in 40 Genes Assessed for Diabetes Incidence and Response to Metformin and Lifestyle Intervention in the Diabetes Prevention Program . Diabetes vol. 59 , ( 10 ) 2672 - 2681 .

Fontaine-Bisson B, Renström F, Rolandsson O, The MAGIC investigators, Payne F, Hallmans G, Barroso I, Franks PW ( 2010 ) . Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population . Diabetologia vol. 53 , ( 10 ) 2155 - 2162 .

Wiklund P, Toss F, Jansson J-H, Eliasson M, Hallmans G, Nordström A, Franks PW, Nordström P ( 2010 ) . Abdominal and gynoid adipose distribution and incident myocardial infarction in women and men . International Journal of Obesity vol. 34 , ( 12 ) 1752 - 1758 .

Franks PW, Knowler WC, Looker HC ( 2010 ) . The authors reply . New England Journal of Medicine vol. 362 , ( 19 ) 1841 - 1842 .

Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL et al. ( 2010 ) . Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk . Nature Genetics vol. 42 , ( 5 ) 464 - 464 .

Gradmark AMI, Rydh A, Renström F, De Lucia-Rolfe E, Sleigh A, Nordström P, Brage S, Franks PW ( 2010 ) . Computed tomography-based validation of abdominal adiposity measurements from ultrasonography, dual-energy X-ray absorptiometry and anthropometry . British Journal Of Nutrition vol. 104 , ( 4 ) 582 - 588 .

Jonsson A, Renström F, Lyssenko V, Brito EC, Isomaa B, Berglund G, Nilsson PM, Groop L et al. ( 2010 ) . Erratum to: Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 finnish adults . Diabetologia vol. 53 , ( 6 ) 1244 - 1244 .

Franks PW, Hanson RL, Knowler WC, Sievers ML, Bennett PH, Looker HC ( 2010 ) . Childhood Obesity, Other Cardiovascular Risk Factors, and Premature Death . The New England Journal of Medicine vol. 362 , ( 6 ) 485 - 493 .

Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL et al. ( 2010 ) . New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk . Nature Genetics vol. 42 , ( 2 ) 105 - 116 .

Fawcett KA, Wheeler E, Morris AP, Ricketts SL, Hallmans G, Rolandsson O, Daly A, Wasson J et al. ( 2009 ) . Detailed Investigation of the Role of Common and Low-Frequency WFS1 Variants in Type 2 Diabetes Risk . Diabetes vol. 59 , ( 3 ) 741 - 746 .

Venti CA, Votruba SB, Franks PW, Krakoff J, Salbe AD ( 2009 ) . Reproducibility of ad libitum energy intake with the use of a computerized vending machine system . American Journal of Clinical Nutrition vol. 91 , ( 2 ) 343 - 348 .

He M, Cornelis MC, Franks PW, Zhang C, Hu FB, Qi L ( 2009 ) . Obesity Genotype Score and Cardiovascular Risk in Women With Type 2 Diabetes Mellitus . Arteriosclerosis Thrombosis and Vascular Biology vol. 30 , ( 2 ) 327 - 332 .

Pomeroy J, Söderberg AM, Franks PW ( 2009 ) . Gene-Lifestyle Interactions and Their Consequences on Human Health . Medicine and Sport Science vol. 54 , 110 - 135 .

Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, Speliotes EK, Thorleifsson G et al. ( 2009 ) . Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution . PLOS Genetics vol. 5 , ( 6 )

Franks PW, Jablonski KA, Delahanty LM, McAteer JB, Kahn SE, Knowler WC, Florez JC, for the Diabetes Prevention Program Research Group ( 2009 ) . Assessing gene–treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program . Diabetologia vol. 52 , ( 7 ) 1456 - 1456 .

Franks PW ( 2009 ) . 144 . Medicine & Science in Sports & Exercise vol. 41 , ( 5 )

Jonsson A, Renström F, Lyssenko V, Brito EC, Isomaa B, Berglund G, Nilsson PM, Groop L et al. ( 2009 ) . Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 Finnish adults . Diabetologia vol. 52 , ( 7 ) 1334 - 1338 .

Eriksson MK, Franks PW, Eliasson M ( 2009 ) . A 3-Year Randomized Trial of Lifestyle Intervention for Cardiovascular Risk Reduction in the Primary Care Setting: The Swedish Björknäs Study . PLOS ONE vol. 4 , ( 4 )

Jonsson A, Franks PW ( 2009 ) . Obesity, FTO Gene Variant, and Energy Intake in Children . The New England Journal of Medicine vol. 360 , ( 15 ) 1571 - 1572 .

Brito EC, Lyssenko V, Renström F, Berglund G, Nilsson PM, Groop L, Franks PW ( 2009 ) . Previously Associated Type 2 Diabetes Variants May Interact With Physical Activity to Modify the Risk of Impaired Glucose Regulation and Type 2 Diabetes A Study of 16,003 Swedish Adults . Diabetes vol. 58 , ( 6 ) 1411 - 1418 .

( 2009 ) . Corrigendum . Journal of Applied Physiology vol. 106 , ( 3 ) 1026 - 1026 .

Brito EC, Vimaleswaran KS, Brage S, Andersen LB, Sardinha LB, Wareham NJ, Ekelund U, Loos RJF et al. ( 2009 ) . PPARGC1A sequence variation and cardiovascular risk-factor levels: a study of the main genetic effects and gene × environment interactions in children from the European Youth Heart Study . Diabetologia vol. 52 , ( 4 ) 609 - 613 .

Renström F, Payne F, Nordström A, Brito EC, Rolandsson O, Hallmans G, Barroso I, Nordström P et al. ( 2009 ) . Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden . Human Molecular Genetics vol. 18 , ( 8 ) 1489 - 1496 .

Franks PW ( 2008 ) . Identifying genes for primary hypertension: methodological limitations and gene–environment interactions . Journal of Human Hypertension vol. 23 , ( 4 ) 227 - 237 .

Franks PW, Jablonski KA, Delahanty LM, McAteer JB, Kahn SE, Knowler WC, Florez JC, for the Diabetes Prevention Program Research Group ( 2008 ) . Assessing gene–treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program . Diabetologia vol. 51 , ( 12 ) 2214 - 2223 .

Wiklund P, Toss F, Weinehall L, Hallmans G, Franks PW, Nordström A, Nordström P ( 2008 ) . Abdominal and Gynoid Fat Mass Are Associated with Cardiovascular Risk Factors in Men and Women . The Journal of Clinical Endocrinology & Metabolism vol. 93 , ( 11 ) 4360 - 4366 .

Ma L, Hanson RL, Que LN, Mack JL, Franks PW, Infante AM, Kobes S, Bogardus C et al. ( 2008 ) . Association Analysis of Krüppel-Like Factor 11 Variants with Type 2 Diabetes in Pima Indians . The Journal of Clinical Endocrinology & Metabolism vol. 93 , ( 9 ) 3644 - 3649 .

Moore AF, Jablonski KA, McAteer JB, Saxena R, Pollin TI, Franks PW, Hanson RL, Shuldiner AR et al. ( 2008 ) . Extension of Type 2 Diabetes Genome-Wide Association Scan Results in the Diabetes Prevention Program . Diabetes vol. 57 , ( 9 ) 2503 - 2510 .

Franks PW, Scheele C, Loos RJF, Nielsen AR, Finucane FM, Wahlestedt C, Pedersen BK, Wareham NJ et al. ( 2008 ) . Genomic variants at the PINK1 locus are associated with transcript abundance and plasma nonesterified fatty acid concentrations in European whites . The FASEB Journal vol. 22 , ( 9 ) 3135 - 3145 .

Vimaleswaran KS, Luan J, Andersen G, Muller YL, Wheeler E, Brito EC, O'Rahilly S, Pedersen O et al. ( 2008 ) . The Gly482Ser genotype at the PPARGC1A gene and elevated blood pressure: a meta-analysis involving 13,949 individuals . Journal of Applied Physiology vol. 105 , ( 4 ) 1352 - 1358 .

Brito EC, Franks PW ( 2008 ) . Commentary on Viewpoint: Perspective on the future use of genomics in exercise prescription . Journal of Applied Physiology vol. 104 , ( 4 ) 1248 - 1248 .

Vimaleswaran KS, Franks PW, Barroso I, Brage S, Ekelund U, Wareham NJ, Loos RJF ( 2008 ) . Habitual Energy Expenditure Modifies the Association Between NOS3 Gene Polymorphisms and Blood Pressure . American Journal of Hypertension vol. 21 , ( 3 ) 297 - 302 .

Franks PW, Rolandsson O, Debenham SL, Fawcett KA, Payne F, Dina C, Froguel P, Mohlke KL et al. ( 2008 ) . Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations . Diabetologia vol. 51 , ( 3 ) 523 - 523 .

Florez JC, Jablonski KA, McAteer J, Sandhu MS, Wareham NJ, Barroso I, Franks PW, Altshuler D et al. ( 2007 ) . Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program . Diabetologia vol. 51 , ( 3 ) 451 - 457 .

Franks PW, Rolandsson O, Debenham SL, Fawcett KA, Payne F, Dina C, Froguel P, Mohlke KL et al. ( 2007 ) . Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations . Diabetologia vol. 51 , ( 3 ) 458 - 463 .

Franks PW, Jablonski KA, Delahanty L, Hanson RL, Kahn SE, Altshuler D, Knowler WC, Florez JC et al. ( 2007 ) . The Pro12Ala variant at the peroxisome proliferator-activated receptor γ gene and change in obesity-related traits in the Diabetes Prevention Program . Diabetologia vol. 50 , ( 12 ) 2451 - 2460 .

Franks PW, Hanson RL, Knowler WC, Moffett C, Enos G, Infante AM, Krakoff J, Looker HC ( 2007 ) . Childhood Predictors of Young-Onset Type 2 Diabetes . Diabetes vol. 56 , ( 12 ) 2964 - 2972 .

Franks PW ( 2007 ) . Muscling in on the genetics of quantitative disease traits . Journal of Applied Physiology vol. 103 , ( 4 ) 1111 - 1112 .

Franks PW, Olsson T ( 2007 ) . Response to Metabolic Syndrome and Early Death: Extending the Discussion on Heterogeneity . Hypertension vol. 50 , ( 1 )

Ekelund U, Franks PW, Sharp S, Brage S, Wareham NJ ( 2007 ) . Increase in Physical Activity Energy Expenditure Is Associated With Reduced Metabolic Risk Independent of Change in Fatness and Fitness . Diabetes Care vol. 30 , ( 8 ) 2101 - 2106 .

Brage S, Ekelund U, Franks PW, Hennings MA, Wright A, Coward A, Wareham NJ ( 2007 ) . Validation of Combined Heart Rate and Movement Sensing to Estimate Free-living Physical Activity Energy Expenditure . Medicine & Science in Sports & Exercise vol. 39 , ( 5 )

Brage S, Ekelund U, Brage N, Hennings MA, Froberg K, Franks PW, Wareham NJ ( 2007 ) . Hierarchy of individual calibration levels for heart rate and accelerometry to measure physical activity . Journal of Applied Physiology vol. 103 , ( 2 ) 682 - 692 .

Loos RJF, Franks PW, Francis RW, Barroso I, Gribble FM, Savage DB, Ong KK, O'Rahilly S et al. ( 2007 ) . TCF7L2 Polymorphisms Modulate Proinsulin Levels and β-Cell Function in a British Europid Population . Diabetes vol. 56 , ( 7 ) 1943 - 1947 .

Franks PW, Wong M-Y, Luan J, Mitchell J, Hennings S, Wareham NJ ( 2007 ) . Non-esterified fatty acid levels and physical inactivity: the relative importance of low habitual energy expenditure and cardio-respiratory fitness . British Journal Of Nutrition vol. 88 , ( 3 ) 307 - 313 .

Mesa JL, Loos RJF, Franks PW, Ong KK, Luan J, O’Rahilly S, Wareham NJ, Barroso I ( 2007 ) . Lamin A/C Polymorphisms, Type 2 Diabetes, and the Metabolic Syndrome Case-Control and Quantitative Trait Studies . Diabetes vol. 56 , ( 3 ) 884 - 889 .

Florez JC, Jablonski KA, Kahn SE, Franks PW, Dabelea D, Hamman RF, Knowler WC, Nathan DM et al. ( 2007 ) . Type 2 Diabetes–Associated Missense Polymorphisms KCNJ11 E23K and ABCC8 A1369S Influence Progression to Diabetes and Response to Interventions in the Diabetes Prevention Program . Diabetes vol. 56 , ( 2 ) 531 - 536 .

Huang TT-K, Ball GDC, Franks PW ( 2007 ) . Metabolic syndrome in youth: current issues and challenges . Applied Physiology Nutrition and Metabolism vol. 32 , ( 1 ) 13 - 22 .

Franks PW, Loos RJF, Brage S, O'Rahilly S, Wareham NJ, Ekelund U ( 2007 ) . Physical activity energy expenditure may mediate the relationship between plasma leptin levels and worsening insulin resistance independently of adiposity . Journal of Applied Physiology vol. 102 , ( 5 ) 1921 - 1926 .

Franks PW, Ekelund U, Brage S, Luan J, Schafer AJ, O’Rahilly S, Barroso I, Wareham NJ ( 2007 ) . PPARGC1A coding variation may initiate impaired NEFA clearance during glucose challenge . Diabetologia vol. 50 , ( 3 ) 569 - 573 .

Franks PW, Scheele C, Loos RJF, Nielsen AR, Pedersen BK, Wareham NJ, Timmons JA ( 2007 ) . Gene expression and genetic association studies suggest a role for the Parkinson's gene <i>PINK1</i> in the pathogenesis of type 2 diabetes . DIABETOLOGIA . vol. 50 , S134 - S134 .

Franks PW, Huang TT-K, Ball GDC ( 2007 ) . Lifestyle Intervention for Type 2 Diabetes Risk Reduction: Using the Diabetes Prevention Program to Inform New Directions in Pediatric Research . Canadian Journal of Diabetes vol. 31 , ( 3 ) 242 - 251 .

Franks PW, Olsson T ( 2006 ) . Metabolic Syndrome and Early Death . Hypertension vol. 49 , ( 1 ) 10 - 12 .

Franks PW, Loos RJF ( 2006 ) . PGC-1&agr; Gene and Physical Activity in Type 2 Diabetes Mellitus . Exercise and Sport Sciences Reviews vol. 34 , ( 4 ) 171 - 175 .

Franks PW, Mesa J-L, Harding AH, Wareham NJ ( 2006 ) . Gene–lifestyle interaction on risk of type 2 diabetes . Nutrition Metabolism and Cardiovascular Diseases vol. 17 , ( 2 ) 104 - 124 .

Franks PW ( 2006 ) . Obesity, inflammatory markers and cardiovascular disease: distinguishing causality from confounding . Journal of Human Hypertension vol. 20 , ( 11 ) 837 - 840 .

Körner A, Ma L, Franks PW, Kiess W, Baier LJ, Stumvoll M, Kovacs P ( 2006 ) . Sex-specific effect of the Val1483Ile polymorphism in the fatty acid synthase gene (FAS) on body mass index and lipid profile in Caucasian children . International Journal of Obesity vol. 31 , ( 2 ) 353 - 358 .

Ekelund U, Franks P, Brage S, Wareham NJ ( 2006 ) . Associations Between Change in Physical Activity Energy Expenditure, Aerobic Fitness and Body Fatness with Cardiovascular Disease Risk Factors: The MRC Ely Study: 11:15AM–11:30AM: 614 . Medicine & Science in Sports & Exercise vol. 38 , ( 5 )

Pomeroy J, Brage S, Begay T, Curtis J, Wareham NJ, Troiano R, Leitzmann MF, Franks PW et al. ( 2006 ) . Cross-Sectional Correlation between Corrected Pedometer Step Counts and Characteristics of Metabolic Disorders in PMerican Indians . Medicine & Science in Sports & Exercise vol. 38 , ( Supplement ) s95 - s96 .

Brage S, Brage N, Ekelund U, Franks P, Froberg K, Wareham N ( 2006 ) . Relationships of Heart Rate and Movement with Physical Activity Intensity . Medicine & Science in Sports & Exercise vol. 38 , ( Supplement )

Franks PW, Looker HC, Kobes S, Touger L, Tataranni PA, Hanson RL, Knowler WC ( 2006 ) . Gestational Glucose Tolerance and Risk of Type 2 Diabetes in Young Pima Indian Offspring . Diabetes vol. 55 , ( 2 ) 460 - 465 .

Barroso I, Luan J, Sandhu MS, Franks PW, Crowley V, Schafer AJ, O’Rahilly S, Wareham NJ ( 2006 ) . Meta-analysis of the Gly482Ser variant in PPARGC1A in type 2 diabetes and related phenotypes . Diabetologia vol. 49 , ( 3 ) 501 - 505 .

Brage S, Brage N, Ekelund U, Luan J, Franks PW, Froberg K, Wareham NJ ( 2005 ) . Effect of combined movement and heart rate monitor placement on physical activity estimates during treadmill locomotion and free-living . European Journal of Applied Physiology vol. 96 , ( 5 ) 517 - 524 .

Franks PW, Ravussin E, Hanson RL, Harper IT, Allison DB, Knowler WC, Tataranni PA, Salbe AD ( 2005 ) . Habitual physical activity in children: the role of genes and the environment 2 . American Journal of Clinical Nutrition vol. 82 , ( 4 ) 901 - 908 .

Kovacs P, Ma L, Hanson RL, Franks P, Stumvoll M, Bogardus C, Baier LJ ( 2005 ) . Genetic variation in UCP2 (uncoupling protein-2) is associated with energy metabolism in Pima Indians . Diabetologia vol. 48 , ( 11 ) 2292 - 2295 .

Franks PW, Luan J, Barroso I, Brage S, Sanchez JLG, Ekelund U, Ríos MS, Schafer AJ et al. ( 2005 ) . Variation in the eNOS Gene Modifies the Association Between Total Energy Expenditure and Glucose Intolerance . Diabetes vol. 54 , ( 9 ) 2795 - 2801 .

Wareham NJ, Brage S, Franks PW, Abbott RA ( 2005 ) . Physical Activity and Insulin Resistance . Insulin Resistance , Wiley

Maffeis C ( 2005 ) . Level of physical activity and adiposity in children: relevance of sedentary behaviors . American Journal of Clinical Nutrition vol. 81 , ( 6 )

Ekelund U, Brage S, Sardhina LB, Anderssen SA, Andersen LB, Harro M, Franks PW, Cooper AR et al. ( 2005 ) . Reply to C Maffeis . American Journal of Clinical Nutrition vol. 81 , ( 6 ) 1449 - 1450 .

Ekelund U, Brage S, Franks PW, Hennings S, Emms S, Wareham NJ ( 2005 ) . Physical Activity Energy Expenditure Predicts Progression Toward the Metabolic Syndrome Independently of Aerobic Fitness in Middle-Aged Healthy Caucasians . Diabetes Care vol. 28 , ( 5 ) 1195 - 1200 .

Ekelund U, Brage S, Franks PW, Hennings S, Emms S, Wong M-Y, Wareham NJ ( 2005 ) . Physical activity energy expenditure predicts changes in body composition in middle-aged healthy whites: effect modification by age 2 . American Journal of Clinical Nutrition vol. 81 , ( 5 ) 964 - 969 .

Brage S, Brage N, Franks PW, Ekelund U, Wareham NJ ( 2005 ) . Reliability and validity of the combined heart rate and movement sensor Actiheart . European Journal of Clinical Nutrition vol. 59 , ( 4 ) 561 - 570 .

Lucia A, Gómez-Gallego F, Barroso I, Rabadán M, Bandrés F, San Juan AF, Chicharro JL, Ekelund U et al. ( 2005 ) . PPARGC1A genotype (Gly482Ser) predicts exceptional endurance capacity in European men . Journal of Applied Physiology vol. 99 , ( 1 ) 344 - 348 .

Boreham CA, Ferreira I, Twisk JW, Gallagher AM, Savage MJ, Murray LJ ( 2005 ) . Response: Physical Activity and Fitness in Arterial Stiffness: What Role Does Exposure Measurement Error Occupy? . Hypertension vol. 45 , ( 2 ) e1 - e2 .

Franks PW ( 2004 ) . White-Coat Hypertension and Risk of Stroke . Hypertension vol. 45 , ( 2 ) 183 - 184 .

Ekelund U, Sardinha LB, Anderssen SA, Harro M, Franks PW, Brage S, Cooper AR, Andersen LB et al. ( 2004 ) . Associations between objectively assessed physical activity and indicators of body fatness in 9- to 10-y-old European children: a population-based study from 4 distinct regions in Europe (the European Youth Heart Study) . American Journal of Clinical Nutrition vol. 80 , ( 3 ) 584 - 590 .

Franks PW, Knowler WC, Nair S, Koska J, Lee Y-H, Lindsay RS, Walker BR, Looker HC et al. ( 2004 ) . Interaction Between an 11&bgr;HSD1 Gene Variant and Birth Era Modifies the Risk of Hypertension in Pima Indians . Hypertension vol. 44 , ( 5 ) 681 - 688 .

Brage S, Wedderkopp N, Ekelund U, Franks PW, Wareham NJ, Andersen LB, Froberg K ( 2004 ) . Features of the Metabolic Syndrome Are Associated With Objectively Measured Physical Activity and Fitness in Danish Children . Diabetes Care vol. 27 , ( 9 ) 2141 - 2148 .

Brage S, Wedderkopp N, Ekelund U, Franks PW, Wareham NJ, Andersen LB, Froberg K ( 2004 ) . Objectively measured physical activity correlates with indices of insulin resistance in Danish children . International Journal of Obesity vol. 28 , ( 11 ) 1503 - 1508 .

Franks PW, Ekelund U, Brage S, Wong M-Y, Wareham NJ ( 2004 ) . Does the Association of Habitual Physical Activity With the Metabolic Syndrome Differ by Level of Cardiorespiratory Fitness? . Diabetes Care vol. 27 , ( 5 ) 1187 - 1193 .

Franks PW, Luan J, Browne PO, Harding A-H, O’Rahilly S, Chatterjee VKK, Wareham NJ ( 2004 ) . Does peroxisome proliferator-activated receptor γ genotype (Pro12ala) modify the association of physical activity and dietary fat with fasting insulin level? . Metabolism vol. 53 , ( 1 ) 11 - 16 .

Franks PW, Bhattacharyya S, Luan J, Montague C, Brennand J, Challis B, Brage S, Ekelund U et al. ( 2003 ) . Association Between Physical Activity and Blood Pressure Is Modified by Variants in the G-Protein Coupled Receptor 10 . Hypertension vol. 43 , ( 2 ) 224 - 228 .

Barroso I, Luan J, Middelberg RPS, Harding A-H, Franks PW, Jakes RW, Clayton D, Schafer AJ et al. ( 2003 ) . Correction: Candidate Gene Association Study in Type 2 Diabetes Indicates a Role for Genes Involved in β-Cell Function as Well as Insulin Action . PLOS Biology vol. 1 , ( 3 )

FRANKS PW, BARROSO I, LUAN J, EKELUND U, CROWLEY VEF, BRAGE S, SANDHU MS, JAKES RW et al. ( 2003 ) . PGC-1&agr; Genotype Modifies the Association of Volitional Energy Expenditure with &OV0312;O2max . Medicine & Science in Sports & Exercise vol. 35 , ( 12 ) 1998 - 2004 .

Barroso I, Luan J, Middelberg RPS, Harding A-H, Franks PW, Jakes RW, Clayton D, Schafer AJ et al. ( 2003 ) . Candidate Gene Association Study in Type 2 Diabetes Indicates a Role for Genes Involved in β-Cell Function as Well as Insulin Action . PLOS Biology vol. 1 , ( 1 )

Brage S, Brage N, Franks PW, Ekelund U, Wong M-Y, Andersen LB, Froberg K, Wareham NJ ( 2003 ) . Branched equation modeling of simultaneous accelerometry and heart rate monitoring improves estimate of directly measured physical activity energy expenditure . Journal of Applied Physiology vol. 96 , ( 1 ) 343 - 351 .

FRANKS PW, BOUTCHER SH ( 2003 ) . Cardiovascular Response of Trained Preadolescent Boys to Mental Challenge . Medicine & Science in Sports & Exercise vol. 35 , ( 8 ) 1429 - 1435 .

BRAGE S, WEDDERKOPP N, FRANKS PW, ANDERSEN LB, FROBERG K ( 2003 ) . Reexamination of Validity and Reliability of the CSA Monitor in Walking and Running . Medicine & Science in Sports & Exercise vol. 35 , ( 8 ) 1447 - 1454 .

Franks PW, Farooqi IS, Luan J, Wong M-Y, Halsall I, O’Rahilly S, Wareham NJ ( 2003 ) . Does Physical Activity Energy Expenditure Explain the Between-Individual Variation in Plasma Leptin Concentrations after Adjusting for Differences in Body Composition? . The Journal of Clinical Endocrinology & Metabolism vol. 88 , ( 7 ) 3258 - 3263 .

Franks PW, Barroso I, Luan J, Brage S, Shafer AJ, O'Rahilly S, Wareham NJ ( 2003 ) . A COMMON VARIANT IN THE ENDOTHELIAL NOS GENE . Medicine & Science in Sports & Exercise vol. 35 , ( 5 )

Bhattacharyya S, Luan J, Challis B, Schmitz C, Clarkson P, Franks PW, Middelberg R, Keogh J et al. ( 2003 ) . Association of Polymorphisms in GPR10, the Gene Encoding the Prolactin-Releasing Peptide Receptor With Blood Pressure, but not Obesity, in a U.K. Caucasian Population . Diabetes vol. 52 , ( 5 ) 1296 - 1299 .

Brage N, Brage S, Franks PW, Froberg K ( 2003 ) . COMBINED ACCELEROMETRY AND HEART RATE MONITORING IMPROVES ESTIMATE OF DIRECTLY MEASURED ENERGY EXPENDITURE . Medicine & Science in Sports & Exercise vol. 35 , ( 5 )

Wareham NJ, Franks PW, Harding A-H ( 2002 ) . Establishing the role of gene-environment interactions in the etiology of type 2 diabetes . Endocrinology and Metabolism Clinics of North America vol. 31 , ( 3 ) 553 - 566 .

Franks PW, Boutcher SH ( 1999 ) . CARDIOVASCULAR RESPONSE OF AEROBICALLY TRAINED AND UNTRAINED PRE-TEENAGE BOYS TO MENTAL CHALLENGE . Medicine & Science in Sports & Exercise vol. 31 , ( 5 )

Atabaki NN, Coral DE, Pomares-Millan H, Smith K, Behjat HH, Koivula RW, Tura A, Miller H et al. . A Biological-Systems-Based Analyses Using Proteomic and Metabolic Network Inference Reveals Mechanistic Insights into Hepatic Lipid Accumulation: An IMI-DIRECT Study .

Ashar FN, Mitchell RN, Albert CM, Newton-Cheh C, Brody JA, Muller-Nurasyid M, Moes A, Meitinger T et al. . A Comprehensive Evaluation of the Genetic Architecture of Sudden Cardiac Arrest .

Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen AU et al. . A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries .

Ramdas S, Judd J, Graham SE, Kanoni S, Wang Y, Surakka I, Wenz B, Clarke SL et al. . A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids .

Franks P, Coral D, Fernández-Tajes J, Pigeyre M, Chong M, Atabaki-Pasdar N, Fitipaldi H, Kalamajski S et al. . A precision medicine approach to coronary artery disease risk prediction and mitigation in people with type 2 diabetes .

Bonander C, Stranges D, Gustavsson J, Almgren M, Inghammar M, Moghaddassi M, Nilsson A, Franks PW et al. . A regression discontinuity analysis of the social distancing recommendations for older adults in Sweden during COVID-19 .

Kennedy B, Fitipaldi H, Hammar U, Maziarz M, Tsereteli N, Oskolkov N, Varotsis G, Franks CA et al. . App-based COVID-19 syndromic surveillance and prediction of hospital admissions: The COVID Symptom Study Sweden .

Sudre CH, Murray B, Varsavsky T, Graham MS, Penfold RS, Bowyer RC, Pujol JC, Klaser K et al. . Attributes and predictors of Long-COVID: analysis of COVID cases and their symptoms collected by the Covid Symptoms Study App .

Corbin LJ, Tan VY, Hughes DA, Wade KH, Paul DS, Tansey KE, Butcher F, Dudbridge F et al. . Causal analyses, statistical efficiency and phenotypic precision through Recall-by-Genotype study design .

Bermingham KM, Mazidi M, Franks PW, Maher T, Valdes AM, Linenberg I, Wolf J, Hadjigeorgiou G et al. . Characterisation of fasting and postprandial NMR metabolites: insights from the ZOE PREDICT 1 Study .

Haworth S, Shungin D, van der Tas JT, Vucic S, Gomez CM, Yakimov V, Feenstra B, Shaffer JR et al. . Consortium genome-wide meta-analysis for childhood dental caries traits .

Varsavsky T, Graham MS, Canas LS, Ganesh S, Pujol JC, Sudre CH, Murray B, Modat M et al. . Detecting COVID-19 infection hotspots in England using large-scale self-reported data from a mobile application: a prospective, observational study .

Merino J, Joshi AD, Nguyen LH, Leeming ER, Mazidi M, Drew DA, Gibson R, Graham MS et al. . Diet quality and risk and severity of COVID-19: a prospective cohort study .

Louca P, Murray B, Klaser K, Graham MS, Mazidi M, Leeming ER, Thompson E, Bowyer R et al. . Dietary supplements during the COVID-19 pandemic: insights from 1.4M users of the COVID Symptom Study app - a longitudinal app-based community survey .

Koivula RW, Forgie IM, Kurbasic A, Viñuela A, Heggie A, Giordano GN, Hansen TH, Hudson M et al. . Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: an overview of the data from the epidemiological studies within the IMI DIRECT Consortium .

Poveda A, Chen Y, Pomares-Millan H, Kurbasic A, Patel CJ, Renström F, Hallmans G, Johansson I et al. . Environment-wide association study (EWAS) on cardiometabolic traits: A systematic assessment of the association of lifestyle variables on a longitudinal setting .

Fragoso-Bargas N, Mcbride NS, Lee-Ødegård S, Lawlor DA, Yousefi PD, Moen G-H, Opsahl JO, Jenum AK et al. . Epigenome-wide association study of objectively measured physical activity in peripheral blood leukocytes .

Viñuela A, Brown AA, Fernandez J, Hong M-G, Brorsson CA, Koivula RW, Davtian D, Dupuis T et al. . Genetic analysis of blood molecular phenotypes reveals regulatory networks affecting complex traits: a DIRECT study .

Ström K, Oskolkov N, Karaderi T, Kalamajski S, Ekström O, Miyamoto-Mikami E, Ladenvall C, Kakulidis E et al. . Genetic variation at RAB3GAP2 and its role in exercise-related adaptation and recovery .

Folkersen L, Gustafsson S, Wang Q, Hansen DH, Hedman ÅK, Schork A, Page K, Zhernakova DV et al. . Genomic evaluation of circulating proteins for drug target characterisation and precision medicine .

Klemp I, Hoffmann A, Müller L, Hagemann T, Horn K, Rohde-Zimmermann K, Tönjes A, Thiery J et al. . Human blood DNA methylation patterns reflect individual lifestyle .

Huang M, Coral D, Ardalani H, Spégel P, Saadat A, Claussnitzer M, Mulder H, Franks PW et al. . Identification of a weight loss-associated causal eQTL in MTIF3 and the effects of MTIF3 deficiency on human adipocyte function .

Mazidii M, Leeming E, Merino J, Nguyen L, Selvachandran S, Maher T, Kadé K, Murray B et al. . Impact of COVID-19 on health behaviours and body weight: A prospective observational study in a cohort of 1.1 million UK and US individuals .

Davtian D, Dupuis T, Aly DM, Atabaki-Pasdar N, Walker M, Franks PW, Rutters F, Im H et al. . Impact of sample size and tissue relevance on T2D gene identification .

Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke SL, Bhatti KF et al. . Implicating genes, pleiotropy and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis .

Atabaki-Pasdar N, Pomares-Millan H, Koivula RW, Tura A, Brown A, Viñuela A, Agudelo L, Coral D et al. . Inferring causal pathways between metabolic processes and liver fat accumulation: an IMI DIRECT study .

Frontini M, Stefanucci L, Moslemi C, Tome A, Virtue S, Gleadall N, Watson L, Kwa J et al. . Loss of function variant in SMIM1 is associated with reduced energy expenditure and weight gain .

Agudelo LZ, Tuyeras R, Llinares C, Morcuende A, Park Y, Sun N, Linna-Kuosmanen S, Atabaki-Pasdar N et al. . Metabolic resilience is encoded in genome plasticity .

Singh T, Kalamajski S, Cunha JPMCM, Hladkou S, Roberts F, Gheibi S, Soltanian A, Farahmand KY et al. . Modelling genetic risk of β-cell dysfunction in human induced pluripotent stem cells from patients carrying the MTNR1B risk variant .

Slieker RC, Donnelly LA, Lopez-Noriega L, Muniangi-Muhitu H, Akalestou E, Sheikh M, Georgiadou E, Giordano GN et al. . Novel biomarkers for glycaemic deterioration in type 2 diabetes: an IMI RHAPSODY study .

Berry S, Drew D, Linenberg I, Wolf J, Hadjigeorgiou G, Davies R, Khatib HA, Hart D et al. . Personalised REsponses to DIetary Composition Trial (PREDICT): an intervention study to determine inter-individual differences in postprandial response to foods .

Atabaki-Pasdar N, Ohlsson M, Viñuela A, Frau F, Pomares-Millan H, Haid M, Jones AG, Thomas EL et al. . Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study .

Pomares-Millan H, Atabaki-Pasdar N, Johansson I, Poveda A, Franks PW . Predicting sensitivity and resilience to modifiable risk factors for cardiometabolic morbidity and mortality .

Justice AE, Karaderi T, Highland HM, Young KL, Graff M, Lu Y, Turcot V, Auer PL et al. . Protein-Coding Variants Implicate Novel Genes Related to Lipid Homeostasis Contributing to Body Fat Distribution .

Nguyen LH, Joshi AD, Drew DA, Merino J, Ma W, Lo C-H, Kwon S, Wang K et al. . Racial and ethnic differences in COVID-19 vaccine hesitancy and uptake .

Mahajan A, Wessel J, Willems SM, Zhao W, Robertson NR, Chu AY, Gan W, Kitajima H et al. . Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes .

Slieker RC, Donnelly LA, Fitipaldi H, Bouland GA, Giordano GN, Åkerlund M, Gerl MJ, Ahlqvist E et al. . Replication and cross-validation of T2D subtypes based on clinical variables: an IMI-RHAPSODY study .

Bodhini D, Morton RW, Santhakumar V, Nakabuye M, Pomares-Millan H, Clemmensen C, Fitzpatrick SL, Guasch-Ferre M et al. . Role of sociodemographic, clinical, behavioral, and molecular factors in precision prevention of type 2 diabetes: a systematic review .

Molteni E, Astley CM, Ma W, Sudre CH, Magee LA, Murray B, Fall T, Gomez MF et al. . SARS-CoV-2 (COVID-19) infection in pregnant women: characterization of symptoms and syndromes predictive of disease and severity through real-time, remote participatory epidemiology .

Franks P, Coral D, Smit F, Farzaneh A, Gieswinkel A, Fernández-Tajes J, Sparsø T, Delfin C et al. . Subclassification of obesity for precision prediction of cardiometabolic diseases: an IMI SOPHIA study .

Coral D, Tajes JF, Tsereteli N, Giordano G, Pomares-Millan H, Mutie P, Atabaki-Pasdar N, Kalamajski S et al. . Subtyping of obesity and type 2 diabetes using genetic discordance: a phenome-wide comparative analysis .

Sudre CH, Lee KA, Lochlainn MN, Varsavsky T, Murray B, Graham MS, Menni C, Modat M et al. . Symptom clusters in Covid19: A potential clinical prediction tool from the COVID Symptom study app .

Connolly B, McCreight L, Slieker RC, Bedair KF, Donnelly L, de Klerk JA, Beulens J, Elders P et al. . The Effect of Metformin Treatment on the Circulating Proteome .

Kalamajski S, Huang M, Baira S, Coral D, Spégel P, Claussnitzer M, Mulder H, Franks P . The Gly482Ser PPARGC1A polymorphism regulates PGC-1α stability and human brown adipocyte mitochondrial function under cold exposure .

Chen J, Spracklen CN, Marenne G, Varshney A, Corbin LJ, Luan J, Willems S, Wu Y et al. . The Trans-Ancestral Genomic Architecture of Glycaemic Traits .

Ng NHJ, Willems SM, Fernandez J, Fine RS, Wheeler E, Wessel J, Kitajima H, Marenne G et al. . Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation .

Pervjakova N, Moen G-H, Borges M-C, Ferreira T, Cook JP, Allard C, Beaumont RN, Canouil M et al. . Trans-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes .

Dawed AY, Zhou K, van Leeuwen N, Mahajan A, Robertson N, Koivula R, Elders PJ, Rauh SP et al. . Variation in the plasma membrane monoamine transporter (PMAT, encoded in SLC29A4) and organic cation transporter 1 (OCT1, encoded in SLC22A1) and gastrointestinal intolerance to metformin in type 2 diabetes: an IMI DIRECT study .