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Research
  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: MR Lachlan Gilchrist

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( 2026 ) . Splitting schizophrenia: divergent cognitive and educational outcomes revealed by genomic structural equation modelling . Molecular Psychiatry1 - 10 .
( 2026 ) . Circulating inflammatory proteins predict dementia risk, and are linked to structural brain changes and modifiable risk factors . Alzheimer's Research & Therapy vol. 18 , ( 1 )
Howard DM, Gilchrist L, Proitsi P, Paul ER, Heilig M, Östman L, Kämpe R, Hamilton JP ( 2025 ) . Immune and metabolic disturbance as a function of genetic risk and phase of illness in major depression . Brain Behavior & Immunity - Health vol. 50 ,
Jareebi MA, Fullerton J, Kancheva AK, Tank R, Gilchrist L, Russell ER, Lyall LM, Ward J et al. ( 2025 ) . Associations and interactions between premorbid cognitive health, apolipoprotein e4 genotype, and incident Alzheimer’s disease in UK Biobank (N = 252,340) . npj Dementia vol. 1 , ( 1 )
Gilchrist L, Mutz J, Hysi P, Legido-Quigley C, Kõks S, Lewis CM, Proitsi P ( 2025 ) . Evaluating metabolome-wide causal effects on risk for psychiatric and neurodegenerative disorders . BMC Medicine vol. 23 , ( 1 )
Gilchrist L, Spargo TP, Green RE, Coleman JRI, Howard DM, Thorp JG, Adey BN, Lord J et al. ( 2025 ) . Depression symptom-specific genetic associations in clinically diagnosed and proxy case Alzheimer’s disease . Nature Mental Health vol. 3 , ( 2 ) 212 - 228 .
Spargo TP, Gilchrist L, Hunt GP, Dobson RJ, Al-Chalabi A, Pain O ( 2024 ) . Statistical examination of shared loci in neuropsychiatric diseases using genome-wide association study summary statistics . eLife vol. 12 ,
Green RE, Lord J, Scelsi MA, Xu J, Wong A, Naomi-James S, Handy A, Gilchrist L et al. ( 2023 ) . Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer’s disease . Alzheimer's Research & Therapy vol. 15 , ( 1 )
Mutz J, Gilchrist L, Pain O, Proitsi P, Lewis CM . Accelerated metabolomic ageing (MileAge) in mid-life predicts incident vascular, unspecified and all-cause dementia .
Liu Y, Abdolkarimi D, Gilchrist L, Calhas S, Wretlind A, Velayudhan L, Ashton NJ, Zetterberg H et al. . Circulating Metabolites are Linked to Dementia and Brain Imaging Phenotypes, and Mediate Modifiable Risk Pathways .
Abdolkarimi D, Liu Y, Gilchrist L, Calhas S, Waters S, Marshall CR, Proitsi P . Circulating inflammatory proteins predict dementia risk, are linked to structural brain changes and reveal risk mediation pathways .
Gilchrist L, Mutz J, Hysi P, Legido-Quigley C, Koks S, Lewis CM, Proitsi P . Evaluating metabolome-wide causal effects on risk for psychiatric and neurodegenerative disorders .
Gilchrist L, Pain O, Marriott H, Pfaff A, Watson CJ, Iacoangeli A, Koks S, Lewis CM et al. . Using polygenic and transcriptional risk scores to investigate psychiatric and cognitive symptoms in Parkinson’s disease .
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