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  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: DR Ann-Marie De Lange

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( 2026 ) . Linking obesity with white matter microstructure highlights the importance of brainstem tracts and sex differences . Brain Communications
( 2026 ) . Longitudinal Associations Between Physical Activity Behavior and Structural Brain MRI Features After Stroke: A Sub-Study From the Nor-COAST Project . Neurorehabilitation and Neural Repair vol. 40 , ( 1 ) 75 - 87 .
Oppenheimer H, Shadrin A, Andersen JØ, Schindler LS, Crestol A, Andreassen OA, Westlye LT, de Lange A-MG et al. ( 2025 ) . Investigating Shared Cardiovascular Factors and Genetic Overlap of Pregnancy-Related Disorders, Major Depressive Disorder, and Alzheimer’s Disease . Biological Psychiatry
Oppenheimer H, van der Meer D, Schindler LS, Crestol A, Shadrin A, Andreassen OA, Westlye LT, de Lange A-MG et al. ( 2025 ) . No causal links between estradiol and female’s brain and mental health using Mendelian randomization . Nature Communications vol. 16 , ( 1 )
Subramaniapillai S, Cole JH, de Lange A-MG ( 2025 ) . Author Response: Sex-Dependent Effects of Cardiometabolic Health and APOE4 on Brain Age . Neurology vol. 105 , ( 9 )
Ambikairajah A, Foxe D, de Lange AG, Carrick J, Cheung SC, Srikanth VK, Hwang YT, Ahmed RM et al. ( 2025 ) . A Bayesian analysis of diagnostic timelines across Alzheimer's disease, frontotemporal dementia, and other neurodegenerative conditions . Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring vol. 17 , ( 3 )
Barth C, Galea LA, Jacobs EG, Lee BH, Westlye LT, de Lange A-MG ( 2025 ) . Menopausal hormone therapy and the female brain: Leveraging neuroimaging and prescription registry data from the UK Biobank cohort . eLife vol. 13 ,
Askeland-Gjerde DE, Westlye LT, Andersson P, Korbmacher M, de Lange A-M, van der Meer D, Smeland OB, Halvorsen S et al. ( 2025 ) . Mediation Analyses Link Cardiometabolic Factors and Liver Fat With White Matter Hyperintensities and Cognitive Performance: A UK Biobank Study . Biological Psychiatry Global Open Science vol. 5 , ( 4 )
Subramaniapillai S, Schindler LS, Redmond P, Bastin ME, Wardlaw JM, Valdés Hernández M, Maniega SM, Aribisala B et al. ( 2024 ) . Sex-Dependent Effects of Cardiometabolic Health and APOE4 on Brain Age . Neurology vol. 103 , ( 6 )
Beck D, Whitmore L, MacSweeney N, Brieant A, Karl V, de Lange A-MG, Westlye LT, Mills KL et al. ( 2024 ) . Dimensions of Early-Life Adversity Are Differentially Associated With Patterns of Delayed and Accelerated Brain Maturation . Biological Psychiatry vol. 97 , ( 1 ) 64 - 72 .
Crestol A, de Lange A-MG, Schindler L, Subramaniapillai S, Nerland S, Oppenheimer H, Westlye LT, Andreassen OA et al. ( 2024 ) . Linking menopause-related factors, history of depression, APOE ε4, and proxies of biological aging in the UK biobank cohort . Hormones and Behavior vol. 164 ,
Beck D, de Lange AG, Gurholt TP, Voldsbekk I, Maximov II, Subramaniapillai S, Schindler L, Hindley G et al. ( 2024 ) . Dissecting unique and common variance across body and brain health indicators using age prediction . Human Brain Mapping vol. 45 , ( 6 )
Sartorius AM, Rokicki J, Birkeland S, Bettella F, Barth C, de Lange A-MG, Haram M, Shadrin A et al. ( 2024 ) . An evolutionary timeline of the oxytocin signaling pathway . Communications Biology vol. 7 , ( 1 )
Martínez-García M, Jacobs EG, de Lange A-MG, Carmona S ( 2024 ) . Advancing the neuroscience of human pregnancy . Nature Neuroscience vol. 27 , ( 5 ) 805 - 807 .
de Lange A-MG, Leonardsen EH, Barth C, Schindler LS, Crestol A, Holm MC, Subramaniapillai S, Hill D et al. ( 2024 ) . Parental status and markers of brain and cellular age: A 3D convolutional network and classification study . Psychoneuroendocrinology vol. 165 ,
Ambikairajah A, Khondoker M, Morris E, de Lange AG, Saleh RNM, Minihane AM, Hornberger M ( 2024 ) . Investigating the synergistic effects of hormone replacement therapy, apolipoprotein E and age on brain health in the UK Biobank . Human Brain Mapping vol. 45 , ( 2 )
Korbmacher M, van der Meer D, Beck D, de Lange A-MG, Eikefjord E, Lundervold A, Andreassen OA, Westlye LT et al. ( 2024 ) . Brain asymmetries from mid- to late life and hemispheric brain age . Nature Communications vol. 15 , ( 1 )
Wierenga LM, Ruigrok A, Aksnes ER, Barth C, Beck D, Burke S, Crestol A, van Drunen L et al. ( 2023 ) . Recommendations for a Better Understanding of Sex and Gender in the Neuroscience of Mental Health . Biological Psychiatry Global Open Science vol. 4 , ( 2 )
Schindler LS, Subramaniapillai S, Ambikairajah A, Barth C, Crestol A, Voldsbekk I, Beck D, Gurholt TP et al. ( 2023 ) . Cardiometabolic health across menopausal years is linked to white matter hyperintensities up to a decade later . Frontiers in Global Women's Health vol. 4 ,
Subramaniapillai S, Am Galea L, Einstein G, de Lange A-M ( 2023 ) . Sex and gender in health research: Intersectionality matters . Frontiers in Neuroendocrinology vol. 72 ,
Barth C, Crestol A, de Lange A-MG, Galea LAM ( 2023 ) . Sex steroids and the female brain across the lifespan: insights into risk of depression and Alzheimer's disease . The Lancet Diabetes & Endocrinology vol. 11 , ( 12 ) 926 - 941 .
Anatürk M, Patel R, Ebmeier KP, Georgiopoulos G, Newby D, Topiwala A, de Lange A-MG, Cole JH et al. ( 2023 ) . Development and validation of a dementia risk score in the UK Biobank and Whitehall II cohorts . BMJ Mental Health vol. 26 , ( 1 )
Pasin C, Consiglio CR, Huisman JS, de Lange A-MG, Peckham H, Vallejo-Yagüe E, Abela IA, Islander U et al. ( 2023 ) . Sex and gender in infection and immunity: addressing the bottlenecks from basic science to public health and clinical applications . Royal Society Open Science vol. 10 , ( 7 )
Korbmacher M, Gurholt TP, de Lange A-MG, van der Meer D, Beck D, Eikefjord E, Lundervold A, Andreassen OA et al. ( 2023 ) . Bio-psycho-social factors’ associations with brain age: a large-scale UK Biobank diffusion study of 35,749 participants . Frontiers in Psychology vol. 14 ,
Korbmacher M, de Lange AM, van der Meer D, Beck D, Eikefjord E, Lundervold A, Andreassen OA, Westlye LT et al. ( 2023 ) . Brain‐wide associations between white matter and age highlight the role of fornix microstructure in brain ageing . Human Brain Mapping vol. 44 , ( 10 ) 4101 - 4119 .
Leonardsen EH, Vidal-Piñeiro D, Roe JM, Frei O, Shadrin AA, Iakunchykova O, de Lange A-MG, Kaufmann T et al. ( 2023 ) . Genetic architecture of brain age and its causal relations with brain and mental disorders . Molecular Psychiatry vol. 28 , ( 7 ) 3111 - 3120 .
Trofimova O, Latypova A, DiDomenicantonio G, Lutti A, de Lange A-MG, Kliegel M, Stringhini S, Marques-Vidal P et al. ( 2023 ) . Topography of associations between cardiovascular risk factors and myelin loss in the ageing human brain . Communications Biology vol. 6 , ( 1 )
Holm MC, Leonardsen EH, Beck D, Dahl A, Kjelkenes R, de Lange A-MG, Westlye LT ( 2023 ) . Linking brain maturation and puberty during early adolescence using longitudinal brain age prediction in the ABCD cohort . Developmental Cognitive Neuroscience vol. 60 ,
Voldsbekk I, Kjelkenes R, Wolfers T, Dahl A, Lund MJ, Kaufmann T, Fernandez-Cabello S, de Lange A-MG et al. ( 2023 ) . Shared pattern of impaired social communication and cognitive ability in the youth brain across diagnostic boundaries . Developmental Cognitive Neuroscience vol. 60 ,
Løchen AR, Kolskår KK, de Lange A-MG, Sneve MH, Haatveit B, Lagerberg TV, Ueland T, Melle I et al. ( 2023 ) . Visual processing deficits in patients with schizophrenia spectrum and bipolar disorders and associations with psychotic symptoms, and intellectual abilities . Heliyon vol. 9 , ( 2 )
Lindseth LRS, de Lange A-MG, van der Meer D, Agartz I, Westlye LT, Tamnes CK, Barth C ( 2023 ) . Associations between reproductive history, hormone use, APOE ε4 genotype and cognition in middle- to older-aged women from the UK Biobank . Frontiers in Aging Neuroscience vol. 14 ,
van der Meer D, Gurholt TP, Sønderby IE, Shadrin AA, Hindley G, Rahman Z, de Lange A-MG, Frei O et al. ( 2022 ) . The link between liver fat and cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body composition . Communications Biology vol. 5 , ( 1 )
Aamodt EB, Alnæs D, de Lange A-MG, Aam S, Schellhorn T, Saltvedt I, Beyer MK, Westlye LT ( 2022 ) . Longitudinal brain age prediction and cognitive function after stroke . Neurobiology of Aging vol. 122 , 55 - 64 .
Schindler LS, Subramaniapillai S, Barth C, van der Meer D, Pedersen ML, Kaufmann T, Maximov II, Linge J et al. ( 2022 ) . Associations between abdominal adipose tissue, reproductive span, and brain characteristics in post-menopausal women . NeuroImage Clinical vol. 36 ,
Bråthen ACS, Sørensen Ø, de Lange A-MG, Mowinckel AM, Fjell AM, Walhovd KB ( 2022 ) . Cognitive and hippocampal changes weeks and years after memory training . Scientific Reports vol. 12 , ( 1 )
Subramaniapillai S, Suri S, Barth C, Maximov II, Voldsbekk I, van der Meer D, Gurholt TP, Beck D et al. ( 2022 ) . Sex‐ and age‐specific associations between cardiometabolic risk and white matter brain age in the UK Biobank cohort . Human Brain Mapping vol. 43 , ( 12 ) 3759 - 3774 .
Rokicki J, Kaufmann T, de Lange A-MG, van der Meer D, Bahrami S, Sartorius AM, Haukvik UK, Steen NE et al. ( 2022 ) . Oxytocin receptor expression patterns in the human brain across development . Neuropsychopharmacology vol. 47 , ( 8 ) 1550 - 1560 .
de Lange AG, Anatürk M, Rokicki J, Han LKM, Franke K, Alnæs D, Ebmeier KP, Draganski B et al. ( 2022 ) . Mind the gap: Performance metric evaluation in brain‐age prediction . Human Brain Mapping vol. 43 , ( 10 ) 3113 - 3129 .
Beck D, de Lange A-MG, Alnæs D, Maximov II, Pedersen ML, Leinhard OD, Linge J, Simon R et al. ( 2022 ) . Adipose tissue distribution from body MRI is associated with cross-sectional and longitudinal brain age in adults . NeuroImage Clinical vol. 33 ,
Lund MJ, Alnæs D, de Lange A-MG, Andreassen OA, Westlye LT, Kaufmann T ( 2021 ) . Brain age prediction using fMRI network coupling in youths and associations with psychiatric symptoms . NeuroImage Clinical vol. 33 ,
Winterton A, Bettella F, de Lange A-MG, Haram M, Steen NE, Westlye LT, Andreassen OA, Quintana DS ( 2021 ) . Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank . Translational Psychiatry vol. 11 , ( 1 )
Beck D, de Lange AG, Pedersen ML, Alnæs D, Maximov II, Voldsbekk I, Richard G, Sanders A et al. ( 2021 ) . Cardiometabolic risk factors associated with brain age and accelerated brain ageing . Human Brain Mapping vol. 43 , ( 2 ) 700 - 720 .
de Lange A-MG, Kaufmann T, Quintana DS, Winterton A, Andreassen OA, Westlye LT, Ebmeier KP ( 2021 ) . Prominent health problems, socioeconomic deprivation, and higher brain age in lonely and isolated individuals: A population-based study . Behavioural Brain Research vol. 414 ,
Sanders A-M, Richard G, Kolskår K, Ulrichsen KM, Kaufmann T, Alnæs D, Beck D, Dørum ES et al. ( 2021 ) . Linking objective measures of physical activity and capability with brain structure in healthy community dwelling older adults . NeuroImage Clinical vol. 31 ,
Voldsbekk I, Barth C, Maximov II, Kaufmann T, Beck D, Richard G, Moberget T, Westlye LT et al. ( 2021 ) . A history of previous childbirths is linked to women's white matter brain age in midlife and older age . Human Brain Mapping vol. 42 , ( 13 ) 4372 - 4386 .
Maximov II, van der Meer D, de Lange AG, Kaufmann T, Shadrin A, Frei O, Wolfers T, Westlye LT ( 2021 ) . Fast qualitY conTrol meThod foR derIved diffUsion Metrics (YTTRIUM) in big data analysis: U.K. Biobank 18,608 example . Human Brain Mapping vol. 42 , ( 10 ) 3141 - 3155 .
Hellstrøm T, Andelic N, de Lange A-MG, Helseth E, Eiklid K, Westlye LT ( 2021 ) . Apolipoprotein ɛ4 Status and Brain Structure 12 Months after Mild Traumatic Injury: Brain Age Prediction Using Brain Morphometry and Diffusion Tensor Imaging . Journal of Clinical Medicine vol. 10 , ( 3 )
Barth C, Nerland S, de Lange A-MG, Wortinger LA, Hilland E, Andreassen OA, Jørgensen KN, Agartz I ( 2021 ) . In Vivo Amygdala Nuclei Volumes in Schizophrenia and Bipolar Disorders . Schizophrenia Bulletin vol. 47 , ( 5 ) 1431 - 1441 .
de Lange A-MG, Jacobs EG, Galea LAM ( 2020 ) . The scientific body of knowledge: Whose body does it serve? A spotlight on women’s brain health . Frontiers in Neuroendocrinology vol. 60 ,
Rokicki J, Wolfers T, Nordhøy W, Tesli N, Quintana DS, Alnæs D, Richard G, de Lange AG et al. ( 2020 ) . Multimodal imaging improves brain age prediction and reveals distinct abnormalities in patients with psychiatric and neurological disorders . Human Brain Mapping vol. 42 , ( 6 ) 1714 - 1726 .
Anatürk M, Kaufmann T, Cole JH, Suri S, Griffanti L, Zsoldos E, Filippini N, Singh‐Manoux A et al. ( 2020 ) . Prediction of brain age and cognitive age: Quantifying brain and cognitive maintenance in aging . Human Brain Mapping vol. 42 , ( 6 ) 1626 - 1640 .
Walhovd KB, Bråthen ACS, Panizzon MS, Mowinckel AM, Sørensen Ø, de Lange A-MG, Krogsrud SK, Håberg A et al. ( 2020 ) . Within-session verbal learning slope is predictive of lifespan delayed recall, hippocampal volume, and memory training benefit, and is heritable . Scientific Reports vol. 10 , ( 1 )
Beck D, de Lange A-MG, Maximov II, Richard G, Andreassen OA, Nordvik JE, Westlye LT ( 2020 ) . White matter microstructure across the adult lifespan: A mixed longitudinal and cross-sectional study using advanced diffusion models and brain-age prediction . NeuroImage vol. 224 ,
de Lange AG, Barth C, Kaufmann T, Maximov II, van der Meer D, Agartz I, Westlye LT ( 2020 ) . Women's brain aging: Effects of sex‐hormone exposure, pregnancies, and genetic risk for Alzheimer's disease . Human Brain Mapping vol. 41 , ( 18 ) 5141 - 5150 .
de Lange A-MG, Anatürk M, Suri S, Kaufmann T, Cole JH, Griffanti L, Zsoldos E, Jensen DEA et al. ( 2020 ) . Multimodal brain-age prediction and cardiovascular risk: The Whitehall II MRI sub-study . NeuroImage vol. 222 ,
de Lange AG, Barth C, Kaufmann T, Anatürk M, Suri S, Ebmeier KP, Westlye LT ( 2020 ) . The maternal brain: Region‐specific patterns of brain aging are traceable decades after childbirth . Human Brain Mapping vol. 41 , ( 16 ) 4718 - 4729 .
Tønnesen S, Kaufmann T, de Lange A-MG, Richard G, Doan NT, Alnæs D, van der Meer D, Rokicki J et al. ( 2020 ) . Brain Age Prediction Reveals Aberrant Brain White Matter in Schizophrenia and Bipolar Disorder: A Multisample Diffusion Tensor Imaging Study . Biological Psychiatry Cognitive Neuroscience and Neuroimaging vol. 5 , ( 12 ) 1095 - 1103 .
Barth C, de Lange A-MG ( 2020 ) . Towards an understanding of women’s brain aging: the immunology of pregnancy and menopause . Frontiers in Neuroendocrinology vol. 58 ,
Bråthen ACS, De Lange A-MG, Fjell AM, Walhovd KB ( 2020 ) . Risk- and protective factors for memory plasticity in aging . Aging Neuropsychology and Cognition vol. 28 , ( 2 ) 201 - 217 .
de Lange A-MG, Cole JH ( 2020 ) . Commentary: Correction procedures in brain-age prediction . NeuroImage Clinical vol. 26 ,
Fjell AM, Sederevicius D, Sneve MH, de Lange A-MG, Bråthen AC, Idland A-V, Watne LO, Wang Y et al. ( 2019 ) . Self-reported Sleep Problems Related to Amyloid Deposition in Cortical Regions with High HOMER1 Gene Expression . Cerebral Cortex vol. 30 , ( 4 ) 2144 - 2156 .
de Lange A-MG, Kaufmann T, van der Meer D, Maglanoc LA, Alnæs D, Moberget T, Douaud G, Andreassen OA et al. ( 2019 ) . Population-based neuroimaging reveals traces of childbirth in the maternal brain . Proceedings of the National Academy of Sciences of the United States of America vol. 116 , ( 44 ) 22341 - 22346 .
Bråthen ACS, de Lange AG, Rohani DA, Sneve MH, Fjell AM, Walhovd KB ( 2018 ) . Multimodal cortical and hippocampal prediction of episodic‐memory plasticity in young and older adults . Human Brain Mapping vol. 39 , ( 11 ) 4480 - 4492 .
de Lange A-MG, Bråthen ACS, Rohani DA, Fjell AM, Walhovd KB ( 2018 ) . The Temporal Dynamics of Brain Plasticity in Aging . Cerebral Cortex vol. 28 , ( 5 ) 1857 - 1865 .
de Lange AG, Bråthen ACS, Rohani DA, Grydeland H, Fjell AM, Walhovd KB ( 2017 ) . The effects of memory training on behavioral and microstructural plasticity in young and older adults . Human Brain Mapping vol. 38 , ( 11 ) 5666 - 5680 .
de Lange A-MG, Bråthen ACS, Grydeland H, Sexton C, Johansen-Berg H, Andersson JLR, Rohani DA, Nyberg L et al. ( 2016 ) . White matter integrity as a marker for cognitive plasticity in aging . Neurobiology of Aging vol. 47 , 74 - 82 .
Walhovd KB, Westerhausen R, de Lange A-MG, Bråthen ACS, Grydeland H, Engvig A, Fjell AM ( 2015 ) . Premises of plasticity — And the loneliness of the medial temporal lobe . NeuroImage vol. 131 , 48 - 54 .
Fjell AM, Sneve MH, Grydeland H, Storsve AB, de Lange A-MG, Amlien IK, Røgeberg OJ, Walhovd KB ( 2015 ) . Functional connectivity change across multiple cortical networks relates to episodic memory changes in aging . Neurobiology of Aging vol. 36 , ( 12 ) 3255 - 3268 .
. Learning diverse and generic representations of the brain with large-scale multi-task pretraining .
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