Publications: PROF Julia Hippisley-Cox

Hippisley-Cox J, Coupland CA ( 2025 ) . Development and external validation of prediction algorithms to improve early diagnosis of cancer . Nature Communications vol. 16 , ( 1 ) Article 3660 ,

Patone M, Snelling AJHL, Tibble H, Coupland C, Sheikh A, Hippisley-Cox J ( 2025 ) . Uptake and safety of Sotrovimab for prevention of severe COVID-19 in a cohort and self-controlled case series study . Communications Medicine vol. 5 , ( 1 ) Article 20 ,

Tzu-Hsuan Chen D, Hirst J, Coupland CAC, Liao W, Baldwin DR, Hippisley-Cox J ( 2025 ) . Ethnic disparities in lung cancer incidence and differences in diagnostic characteristics: a population-based cohort study in England . The Lancet Regional Health - Europe vol. 48 , Article 101124 , 101124 - 101124 .

De Crescenzo F, De Giorgi R, Garriga C, Liu Q, Fazel S, Efthimiou O, Hippisley-Cox J, Cipriani A ( 2024 ) . Real-world effects of antidepressants for depressive disorder in primary care: population-based cohort study . The British Journal of Psychiatry vol. 226 , ( 5 ) 278 - 287 .

( 2024 ) . Establishing the QResearch Pregnancy Register in the QResearch® database: methods and cohort description .

Khanna K, Barnes E, Benselin J, Culver E, Irving W, Innes H, Pavlides M, Consortium D ( 2024 ) . Prospective cohort for early detection of liver cancer (Pearl): a study protocol . BMJ Open vol. 14 , ( 10 ) e085541 - e085541 .

Saatci D, Saatci D, Oke J, Harnden A, Hippisley-Cox J ( 2024 ) . 6810 Identifying early symptoms associated with a diagnosis of childhood, adolescent and young adult cancers: a population-based nested case-control study . Children’s Cancer and Leukaemia Group . Conference: Royal College of Paediatrics and Child Health, Abstracts of the RCPCH Conference, Birmingham, 25 March 2024 – 27 March 2024A258.1 - A258 .

Saatci D, Oke J, Harnden A, Hippisley-Cox J ( 2024 ) . Identifying early symptoms associated with a diagnosis of childhood, adolescent and young adult cancers: a population-based nested case-control study . British Journal of Cancer vol. 131 , ( 6 ) 1032 - 1042 .

Copland E, Patone M, Saatci D, Handunnetthi L, Hirst J, Hunt DPJ, Mills NL, Moss P et al. ( 2024 ) . Author Correction: Safety outcomes following COVID-19 vaccination and infection in 5.1 million children in England . Nature Communications vol. 15 , ( 1 ) Article 5723 ,

( 2024 ) . Development and validation of risk prediction models for childhood, teenage and young adult cancers: research protocol and statistical analysis plan .

Cardwell CR, Ranger TA, Labeit AM, Coupland CAC, Hicks B, Hughes C, McMenamin Ú, Mei XW et al. ( 2024 ) . Hormone replacement therapy and cancer mortality in women with 17 site-specific cancers: a cohort study using linked medical records . British Journal of Cancer vol. 131 , ( 4 ) 737 - 746 .

Dixon S, Vincent K, Hirst J, Hippisley-Cox J ( 2024 ) . Incidence of menstrual symptoms suggestive of possible endometriosis in adolescents: and variance in these by ethnicity and socio-economic status . British Journal of General Practice vol. 74 , ( suppl 1 ) bjgp24X737685 - bjgp24X737685 .

Saatci D, Zhu C, Harnden A, Hippisley-Cox J ( 2024 ) . Presentation of B-cell lymphoma in childhood and adolescence: a systematic review and meta-analysis . BMC Cancer vol. 24 , ( 1 ) Article 718 ,

Chen DT-H, Copland E, Hirst JA, Mi E, Dixon S, Coupland C, Hippisley-Cox J ( 2024 ) . Uptake, effectiveness and safety of COVID-19 vaccines in individuals at clinical risk due to immunosuppressive drug therapy or transplantation procedures: a population-based cohort study in England . BMC Medicine vol. 22 , ( 1 ) Article 237 ,

Copland E, Patone M, Saatci D, Handunnetthi L, Hirst J, Hunt DPJ, Mills NL, Moss P et al. ( 2024 ) . Safety outcomes following COVID-19 vaccination and infection in 5.1 million children in England . Nature Communications vol. 15 , ( 1 ) Article 3822 ,

Clift AK, Tan PS, Patone M, Liao W, Coupland C, Bashford-Rogers R, Sivakumar S, Hippisley-Cox J ( 2024 ) . Predicting the risk of pancreatic cancer in adults with new-onset diabetes: development and internal–external validation of a clinical risk prediction model . British Journal of Cancer vol. 130 , ( 12 ) 1969 - 1978 .

Ahmed H, Reeve N, Farewell D, Hamilton F, Ponsford M, Hippisley‐Cox J, Noble S ( 2024 ) . Risk of bleeding amongst warfarin and direct oral anticoagulant users prescribed immediate antibiotics for respiratory tract infection: Cohort study . Pharmacoepidemiology and Drug Safety vol. 33 , ( 5 ) Article e5794 ,

( 2024 ) . New risk score for cardiovascular disease with improved performance . Nature Medicine vol. 30 , ( 5 ) 1255 - 1256 .

Hippisley-Cox J, Coupland CAC, Bafadhel M, Russell REK, Sheikh A, Brindle P, Channon KM ( 2024 ) . Development and validation of a new algorithm for improved cardiovascular risk prediction . Nature Medicine vol. 30 , ( 5 ) 1440 - 1447 .

Gleeson F ( 2024 ) . 15 The Integration and Analysis of Data using Artificial Intelligence to Improve Patient Outcomes with Thoracic Diseases (DART) research programme . Lung Cancer vol. 190 , Article 107576 , 107576 - 107576 .

Copland E, Hirst J, Mi E, Patone M, Chen D, Coupland C, Hippisley-Cox J ( 2024 ) . Effectiveness and safety of COVID-19 vaccination in people with blood cancer . European Journal of Cancer vol. 201 , Article 113603 , 113603 - 113603 .

Kerr S, Millington T, Rudan I, McCowan C, Tibble H, Jeffrey K, Fagbamigbe AF, Simpson CR et al. ( 2023 ) . External validation of the QCovid 2 and 3 risk prediction algorithms for risk of COVID-19 hospitalisation and mortality in adults: a national cohort study in Scotland . BMJ Open vol. 13 , ( 12 ) e075958 - e075958 .

Tanner KT, Keogh RH, Coupland CAC, Hippisley-Cox J, Diaz-Ordaz K ( 2023 ) . Dynamic updating of clinical survival prediction models in a changing environment . Diagnostic and Prognostic Research vol. 7 , ( 1 ) Article 24 ,

Jack RH, Joseph RM, Hollis C, Hippisley-Cox J, Butler D, Waldram D, Coupland C ( 2023 ) . Seasonal trends in antidepressant prescribing, depression, anxiety and self-harm in adolescents and young adults: an open cohort study using English primary care data . BMJ Mental Health vol. 26 , ( 1 ) e300855 - e300855 .

( 2023 ) . Uptake, effectiveness and safety of COVID-19 vaccines in the immunocompromised population: A population-based cohort study in England .

Jack RH, Coupland CAC, Joseph RM, Hollis C, Morriss R, Knaggs RD, Cipriani A, Cortese S et al. ( 2023 ) . Importance of accurate and accessible recording of healthcare contacts in mental health . BMC Medicine vol. 21 , ( 1 ) Article 346 ,

Hippisley-Cox J, Mei W, Fitzgerald R, Coupland C ( 2023 ) . Development and validation of a novel risk prediction algorithm to estimate 10-year risk of oesophageal cancer in primary care: prospective cohort study and evaluation of performance against two other risk prediction models . The Lancet Regional Health - Europe vol. 32 , Article 100700 , 100700 - 100700 .

Clift AK, Collins GS, Lord S, Petrou S, Dodwell D, Brady M, Hippisley-Cox J ( 2023 ) . Predicting 10-year breast cancer mortality risk in the general female population in England: a model development and validation study . The Lancet Digital Health vol. 5 , ( 9 ) e571 - e581 .

Liao W, Coupland CAC, Burchardt J, Baldwin DR, Gleeson FV, Hippisley-Cox J, Gleeson F, Baldwin D et al. ( 2023 ) . Predicting the future risk of lung cancer: development, and internal and external validation of the CanPredict (lung) model in 19·67 million people and evaluation of model performance against seven other risk prediction models . The Lancet Respiratory Medicine vol. 11 , ( 8 ) 685 - 697 .

Jack R, Joseph R, Hollis C, Hippisley-Cox J, Butler D, Waldram D, Coupland C ( 2023 ) . Seasonal trends in antidepressant prescribing, depression, anxiety, and self-harm in adolescents and young adults: an open cohort study using UK primary care data . British Journal of General Practice vol. 73 , ( suppl 1 ) bjgp23X733677 - bjgp23X733677 .

Hippisley-Cox J, Khunti K, Sheikh A, Nguyen-Van-Tam JS, Coupland CAC ( 2023 ) . Risk prediction of covid-19 related death or hospital admission in adults testing positive for SARS-CoV-2 infection during the omicron wave in England (QCOVID4): cohort study . BMJe072976 - e072976 .

Lyons J, Nafilyan V, Akbari A, Bedston S, Harrison E, Hayward A, Hippisley-Cox J, Kee F et al. ( 2023 ) . An external validation of the QCOVID3 risk prediction algorithm for risk of hospitalisation and death from COVID-19: An observational, prospective cohort study of 1.66m vaccinated adults in Wales, UK . PLOS ONE vol. 18 , ( 5 ) e0285979 - e0285979 .

Clift AK, Dodwell D, Lord S, Petrou S, Brady M, Collins GS, Hippisley-Cox J ( 2023 ) . Development and internal-external validation of statistical and machine learning models for breast cancer prognostication: cohort study . BMJe073800 - e073800 .

Liao W, Coupland CAC, Innes H, Jepsen P, Matthews PC, Campbell C, Barnes E, Hippisley-Cox J et al. ( 2023 ) . Disparities in care and outcomes for primary liver cancer in England during 2008–2018: a cohort study of 8.52 million primary care population using the QResearch database . eClinicalMedicine vol. 59 , Article 101969 , 101969 - 101969 .

( 2023 ) . Dynamic Updating of Clinical Survival Prediction Models in a Rapidly Changing Environment .

Hirst J, Mi E, Copland E, Patone M, Coupland C, Hippisley-Cox J ( 2023 ) . Uptake of COVID-19 vaccination in people with blood cancer: Population-level cohort study of 12 million patients in England . European Journal of Cancer vol. 183 , 162 - 170 .

Tan PS, Patone M, Clift AK, Dambha-Miller H, Saatci D, Ranger TA, Garriga C, Zaccardi F et al. ( 2023 ) . Factors influencing influenza, pneumococcal and shingles vaccine uptake and refusal in older adults: a population-based cross-sectional study in England . BMJ Open vol. 13 , ( 3 ) e058705 - e058705 .

Campbell C, Wang T, Burrow R, Mandal S, Hippisley-Cox J, Barnes E, Matthews PC ( 2023 ) . Estimating the epidemiology of chronic Hepatitis B Virus (HBV) infection in the UK: what do we know and what are we missing? . Wellcome Open Research vol. 7 , 203 - 203 .

Mills NL, Patone M, Hippisley-Cox J ( 2023 ) . Response by Mills et al Regarding Article, “Risk of Myocarditis After Sequential Doses of COVID-19 Vaccine and SARS-CoV-2 Infection by Age and Sex” . Circulation vol. 147 , ( 10 )

Zaccardi F, Tan PS, Shah BR, Everett K, Clift AK, Patone M, Saatci D, Coupland C et al. ( 2023 ) . Ethnic disparities in COVID-19 outcomes: a multinational cohort study of 20 million individuals from England and Canada . BMC Public Health vol. 23 , ( 1 ) Article 399 ,

Dixon S, Ranger TA, Burchardt J, Patone M, Snelling AJHL, Vincent K, Hippisley-Cox J ( 2023 ) . Exploring the interface between adolescent dysmenorrhoea and endometriosis: a protocol for a cohort and nested case–control study within the QResearch Database . BMJ Open vol. 13 , ( 2 ) e069984 - e069984 .

Ranger TA, Clift AK, Patone M, Coupland CAC, Hatch R, Thomas K, Watkinson P, Hippisley-Cox J ( 2023 ) . Preexisting Neuropsychiatric Conditions and Associated Risk of Severe COVID-19 Infection and Other Acute Respiratory Infections . JAMA Psychiatry vol. 80 , ( 1 ) 57 - 57 .

Ranger TA, Clift AK, Patone M, Coupland CAC, Hatch R, Thomas K, Watkinson P, Hippisley-Cox J ( 2023 ) . Preexisting Neuropsychiatric Conditions and Associated Risk of Severe COVID-19 Infection and Other Acute Respiratory Infections . JAMA psychiatry vol. 80 , ( 1 ) 57 - 65 .

( 2022 ) . Analysis of uptake, effectiveness and safety of COVID-19 vaccinations in pregnancy using the QResearch® database: research protocol and statistical analysis plan .

Briggs SEW, Law P, East JE, Wordsworth S, Dunlop M, Houlston R, Hippisley-Cox J, Tomlinson I ( 2022 ) . Integrating genome-wide polygenic risk scores and non-genetic risk to predict colorectal cancer diagnosis using UK Biobank data: population based cohort study . BMJe071707 - e071707 .

Liao W, Jepsen P, Coupland C, Innes H, Matthews PC, Campbell C, Barnes E, Hippisley-Cox J ( 2022 ) . Development and validation of personalised risk prediction models for early detection and diagnosis of primary liver cancer among the English primary care population using the QResearch® database: research protocol and statistical analysis plan . Diagnostic and Prognostic Research vol. 6 , ( 1 ) Article 21 ,

( 2022 ) . Impact of vaccination on COVID-19-associated admissions to critical care in England: a population cohort study of linked data .

Zaccardi F, Tan PS, Coupland C, Shah BR, Clift AK, Saatci D, Patone M, Griffin SJ et al. ( 2022 ) . Ethnicity and risks of severe <scp>COVID</scp>‐19 outcomes associated with glucose‐lowering medications: A cohort study . Diabetes, Obesity and Metabolism vol. 25 , ( 2 ) 611 - 617 .

Patone M, Mei XW, Handunnetthi L, Dixon S, Zaccardi F, Shankar-Hari M, Watkinson P, Khunti K et al. ( 2022 ) . Risk of Myocarditis After Sequential Doses of COVID-19 Vaccine and SARS-CoV-2 Infection by Age and Sex . Circulation vol. 146 , ( 10 ) 743 - 754 .

Harrison D, Watkinson P, Doidge J, Shankar-Hari M, Mouncey P, Patone M, Coupland C, Hippisley-Cox J et al. ( 2022 ) . Impact of vaccination on COVID-19-associated admissions to critical care in England: a study of population linked data with quantitative bias analysis for linkage error . International Journal of Population Data Science vol. 7 , ( 3 )

Dambha-Miller H, Hinton W, Wilcox CR, Lemanska A, Joy M, Feher M, Stuart B, de Lusignan S et al. ( 2022 ) . Mortality from angiotensin-converting enzyme-inhibitors and angiotensin receptor blockers in people infected with COVID-19: a cohort study of 3.7 million people . Family Practice vol. 40 , ( 2 ) 330 - 337 .

( 2022 ) . Uptake of Sotrovimab for prevention of severe COVID-19 and its safety in the community in England .

( 2022 ) . QCovid 4 - Predicting risk of death or hospitalisation from COVID-19 in adults testing positive for SARS-CoV-2 infection during the Omicron wave in England .

Campbell C, Wang T, Burrow R, Mandal S, Hippisley-Cox J, Barnes E, Matthews PC ( 2022 ) . Estimating the epidemiology of chronic Hepatitis B Virus (HBV) infection in the UK: what do we know and what are we missing? . Wellcome Open Research vol. 7 , 203 - 203 .

Ward IL, Bermingham C, Ayoubkhani D, Gethings OJ, Pouwels KB, Yates T, Khunti K, Hippisley-Cox J et al. ( 2022 ) . Risk of covid-19 related deaths for SARS-CoV-2 omicron (B.1.1.529) compared with delta (B.1.617.2): retrospective cohort study . BMJe070695 - e070695 .

Piernas C, Patone M, Astbury NM, Gao M, Sheikh A, Khunti K, Shankar-Hari M, Dixon S et al. ( 2022 ) . Associations of BMI with COVID-19 vaccine uptake, vaccine effectiveness, and risk of severe COVID-19 outcomes after vaccination in England: a population-based cohort study . The Lancet Diabetes &amp; Endocrinology vol. 10 , ( 8 ) 571 - 580 .

Thygesen JH, Tomlinson C, Hollings S, Mizani MA, Handy A, Akbari A, Banerjee A, Cooper J et al. ( 2022 ) . COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records . The Lancet Digital Health vol. 4 , ( 7 ) e542 - e557 .

Clift AK, Ranger TA, Patone M, Coupland CAC, Hatch R, Thomas K, Hippisley-Cox J, Watkinson P ( 2022 ) . Neuropsychiatric Ramifications of Severe COVID-19 and Other Severe Acute Respiratory Infections . JAMA Psychiatry vol. 79 , ( 7 ) 690 - 690 .

Mei XW, Burchardt J, Ranger TA, McDermott CJ, Radunovic A, Coupland C, Hippisley-Cox J ( 2022 ) . Identifying key signs of motor neurone disease in primary care: a nested case–control study using the QResearch database . BMJ Open vol. 12 , ( 6 ) e058383 - e058383 .

Tan PS, Garriga C, Clift A, Liao W, Patone M, Coupland C, Bashford-Rogers R, Sivakumar S et al. ( 2022 ) . Temporality of body mass index, blood tests, comorbidities and medication use as early markers for pancreatic ductal adenocarcinoma (PDAC): a nested case–control study . Gut vol. 72 , ( 3 ) 512 - 521 .

Kerr S, Robertson C, Nafilyan V, Lyons RA, Kee F, Cardwell CR, Coupland C, Lyons J et al. ( 2022 ) . Common protocol for validation of the QCOVID algorithm across the four UK nations . BMJ Open vol. 12 , ( 6 ) e050994 - e050994 .

( 2022 ) . Predicting the future risk of lung cancer: development and validation of QCancer2 (10-year risk) lung model and evaluating the model performance of nine prediction models .

( 2022 ) . Estimating the epidemiology of chronic Hepatitis B Virus (HBV) infection in the UK: what do we know and what are we missing? .

Clift AK, Hippisley-Cox J, Dodwell D, Lord S, Brady M, Petrou S, Collins GS ( 2022 ) . Development and validation of clinical prediction models for breast cancer incidence and mortality: a protocol for a dual cohort study . BMJ Open vol. 12 , ( 3 ) e050828 - e050828 .

Saatci D, Oke J, Harnden A, Hippisley-Cox J ( 2022 ) . Childhood, teenage and young adult cancer diagnosis during the first wave of the COVID-19 pandemic: a population-based observational cohort study in England . Archives of Disease in Childhood vol. 107 , ( 8 ) 740 - 746 .

Joseph RM, Jack RH, Morriss R, Knaggs RD, Butler D, Hollis C, Hippisley-Cox J, Coupland C ( 2022 ) . Association between mirtazapine use and serious self-harm in people with depression: an active comparator cohort study using UK electronic health records . Evidence Based Mental Health vol. 25 , ( 4 ) 169 - 176 .

( 2022 ) . Risk of COVID-19 related deaths for SARS-CoV-2 Omicron (B.1.1.529) compared with Delta (B.1.617.2) .

Gao M, Aveyard P, Lindson N, Hartmann-Boyce J, Watkinson P, Young D, Coupland C, Clift AK et al. ( 2022 ) . Association between smoking, e-cigarette use and severe COVID-19: a cohort study . International Journal of Epidemiology vol. 51 , ( 4 ) 1062 - 1072 .

Henry JA, Jebb SA, Aveyard P, Garriga C, Hippisley-Cox J, Piernas C ( 2022 ) . Lifestyle advice for hypertension or diabetes: trend analysis from 2002 to 2017 in England . British Journal of General Practice vol. 72 , ( 717 ) e269 - e275 .

Lyons J, Nafilyan V, Akbari A, Davies G, Griffiths R, Harrison E, Hippisley-Cox J, Hollinghurst J et al. ( 2022 ) . Validating the QCOVID risk prediction algorithm for risk of mortality from COVID-19 in the adult population in Wales, UK . International Journal of Population Data Science vol. 5 , ( 4 )

Joseph RM, Jack RH, Morriss R, Knaggs RD, Butler D, Hollis C, Hippisley-Cox J, Coupland C ( 2022 ) . The risk of all-cause and cause-specific mortality in people prescribed mirtazapine: an active comparator cohort study using electronic health records . BMC Medicine vol. 20 , ( 1 ) Article 43 ,

Burchardt JM, Mei XW, Ranger T, McDermott CJ, Radunovic A, Coupland C, Hippisley-Cox J ( 2022 ) . Analysis of incidence of motor neuron disease in England 1998–2019: use of three linked datasets . Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration vol. 23 , ( 5-6 ) 363 - 371 .

( 2022 ) . Development and validation of personalised risk prediction models for early detection and diagnosis of primary liver cancer among the English primary care population using the QResearch^® database: research protocol and statistical analysis plan .

Usher‐Smith JA, Li L, Roberts L, Harrison H, Rossi SH, Sharp SJ, Coupland C, Hippisley‐Cox J et al. ( 2022 ) . Risk models for recurrence and survival after kidney cancer: a systematic review . BJU International vol. 130 , ( 5 ) 562 - 579 .

( 2022 ) . Development, validation, and evaluation of prediction models to identify individuals at high risk of lung cancer for screening in the English primary care population using the QResearch^® database: research protocol and statistical analysis plan .

( 2021 ) . Predicting risk of pancreatic cancer in individuals with new-onset type-2 diabetes in primary care: protocol for the development and validation of a clinical prediction model (QPancreasD) .

( 2021 ) . Risk of myocarditis following sequential COVID-19 vaccinations by age and sex .

Ahmed H, Whitaker H, Farewell D, Hippisley-Cox J, Noble S ( 2021 ) . Respiratory tract infection and risk of bleeding in oral anticoagulant users: self-controlled case series . BMJe068037 - e068037 .

Patone M, Mei XW, Handunnetthi L, Dixon S, Zaccardi F, Shankar-Hari M, Watkinson P, Khunti K et al. ( 2021 ) . Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection . Nature Medicine vol. 28 , ( 2 ) 410 - 422 .

Patone M, Handunnetthi L, Saatci D, Pan J, Katikireddi SV, Razvi S, Hunt D, Mei XW et al. ( 2021 ) . Publisher Correction: Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection . Nature Medicine vol. 27 , ( 12 ) 2249 - 2249 .

Simpson CR, Robertson C, Kerr S, Shi T, Vasileiou E, Moore E, McCowan C, Agrawal U et al. ( 2021 ) . External validation of the QCovid risk prediction algorithm for risk of COVID-19 hospitalisation and mortality in adults: national validation cohort study in Scotland . Thorax vol. 77 , ( 5 ) 497 - 504 .

Patone M, Thomas K, Hatch R, Tan PS, Coupland C, Liao W, Mouncey P, Harrison D et al. ( 2021 ) . Mortality and critical care unit admission associated with the SARS-CoV-2 lineage B.1.1.7 in England: an observational cohort study . The Lancet Infectious Diseases vol. 21 , ( 11 ) 1518 - 1528 .

Clift AK, Dodwell D, Lord S, Petrou S, Brady SM, Collins GS, Hippisley-Cox J ( 2021 ) . The current status of risk-stratified breast screening . British Journal of Cancer vol. 126 , ( 4 ) 533 - 550 .

Patone M, Handunnetthi L, Saatci D, Pan J, Katikireddi SV, Razvi S, Hunt D, Mei XW et al. ( 2021 ) . Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection . Nature Medicine vol. 27 , ( 12 ) 2144 - 2153 .

Clift AK, Saatci D, Coupland CAC, Dambha-Miller H, Hippisley-Cox J ( 2021 ) . Sickle Cell Disorders and Severe COVID-19 Outcomes: A Cohort Study . Annals of Internal Medicine vol. 174 , ( 10 ) 1483 - 1487 .

Vinogradova Y, Dening T, Hippisley-Cox J, Taylor L, Moore M, Coupland C ( 2021 ) . Use of menopausal hormone therapy and risk of dementia: nested case-control studies using QResearch and CPRD databases . BMJn2182 - n2182 .

Clift AK, von Ende A, Tan PS, Sallis HM, Lindson N, Coupland CAC, Munafò MR, Aveyard P et al. ( 2021 ) . Smoking and COVID-19 outcomes: an observational and Mendelian randomisation study using the UK Biobank cohort . Thorax vol. 77 , ( 1 ) 65 - 73 .

( 2021 ) . Integrating genome-wide polygenic risk scores and non-genetic risk to predict colorectal cancer diagnosis: a cohort study in UK Biobank .

( 2021 ) . Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: national prospective cohort study . BMJn2300 - n2300 .

Hippisley-Cox J, Coupland CAC, Mehta N, Keogh RH, Diaz-Ordaz K, Khunti K, Lyons RA, Kee F et al. ( 2021 ) . Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: national prospective cohort study . BMJn2244 - n2244 .

Saatci D, Ranger TA, Garriga C, Clift AK, Zaccardi F, Tan PS, Patone M, Coupland C et al. ( 2021 ) . Association Between Race and COVID-19 Outcomes Among 2.6 Million Children in England . JAMA Pediatrics vol. 175 , ( 9 ) 928 - 928 .

Hippisley-Cox J, Patone M, Mei XW, Saatci D, Dixon S, Khunti K, Zaccardi F, Watkinson P et al. ( 2021 ) . Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: self-controlled case series study . BMJn1931 - n1931 .

Persson MSM, Harman KE, Thomas KS, Chalmers JR, Vinogradova Y, Langan SM, Hippisley-Cox J, Gran S ( 2021 ) . Long-term oral prednisolone exposure in primary care for bullous pemphigoid: population-based study . British Journal of General Practice vol. 71 , ( 713 ) e904 - e911 .

Ranger TA, Burchardt J, Clift AK, Mei WX, Coupland C, Tan PS, Dixon S, Cardwell CR et al. ( 2021 ) . Hormone replacement therapy and cancer survival: a longitudinal cohort study: protocol paper . BMJ Open vol. 11 , ( 8 ) e046701 - e046701 .

Aveyard P, Gao M, Lindson N, Hartmann-Boyce J, Watkinson P, Young D, Coupland CAC, Tan PS et al. ( 2021 ) . Association between pre-existing respiratory disease and its treatment, and severe COVID-19: a population cohort study . The Lancet Respiratory Medicine vol. 9 , ( 8 ) 909 - 923 .

( 2021 ) . Correction to: Integrated Polygenic Tool Substantially Enhances Coronary Artery Disease Prediction . Circulation: Genomic and Precision Medicine vol. 14 , ( 4 ) Article e000085 ,

Liao W, Clift AK, Patone M, Coupland C, González-Izquierdo A, Pereira SP, Hippisley-Cox J ( 2021 ) . Identifying symptoms associated with diagnosis of pancreatic exocrine and neuroendocrine neoplasms: a nested case-control study of the UK primary care population . British Journal of General Practice vol. 71 , ( 712 ) e836 - e845 .

( 2021 ) . P76: Long‐term oral prednisolone exposure in primary care for bullous pemphigoid: a population‐based study . British Journal of Dermatology . vol. 185 , 62 - 62 .

Nafilyan V, Humberstone B, Mehta N, Diamond I, Coupland C, Lorenzi L, Pawelek P, Schofield R et al. ( 2021 ) . An external validation of the QCovid risk prediction algorithm for risk of mortality from COVID-19 in adults: a national validation cohort study in England . The Lancet Digital Health vol. 3 , ( 7 ) e425 - e433 .

Gao M, Piernas C, Astbury NM, Hippisley-Cox J, O'Rahilly S, Aveyard P, Jebb SA ( 2021 ) . Associations between body-mass index and COVID-19 severity in 6·9 million people in England: a prospective, community-based, cohort study . The Lancet Diabetes &amp; Endocrinology vol. 9 , ( 6 ) 350 - 359 .

Dambha-Miller H, Tan PS, Saatci D, Clift AK, Zaccardi F, Coupland C, Locufier P, Davies F et al. ( 2021 ) . Quantifying the association between ethnicity and COVID-19 mortality: a national cohort study protocol . BMJ Open vol. 11 , ( 4 ) e045286 - e045286 .

Clift AK, Coupland CAC, Keogh RH, Hemingway H, Hippisley-Cox J ( 2021 ) . COVID-19 Mortality Risk in Down Syndrome: Results From a Cohort Study of 8 Million Adults . Annals of Internal Medicine vol. 174 , ( 4 ) 572 - 576 .

Riveros-Mckay F, Weale ME, Moore R, Selzam S, Krapohl E, Sivley RM, Tarran WA, Sørensen P et al. ( 2021 ) . Integrated Polygenic Tool Substantially Enhances Coronary Artery Disease Prediction . Circulation: Genomic and Precision Medicine vol. 14 , ( 2 ) Article e003304 ,

McMenamin Ú, Hicks B, Hughes C, Murchie P, Hippisley-Cox J, Ranger T, Coupland C, Cardwell C ( 2021 ) . Hormone replacement therapy in women with cancer and risk of cancer-specific mortality and cardiovascular disease: a protocol for a cohort study from Scotland and Wales . BMC Cancer vol. 21 , ( 1 ) Article 313 ,

( 2021 ) . Analysis of severe outcomes associated with the SARS-CoV-2 Variant of Concern 202012/01 in England using ICNARC Case Mix Programme and QResearch databases .

Dambha-Miller H, Griffin SJ, Young D, Watkinson P, Tan PS, Clift AK, Payne RA, Coupland C et al. ( 2021 ) . The Use of Primary Care Big Data in Understanding the Pharmacoepidemiology of COVID-19: A Consensus Statement From the COVID-19 Primary Care Database Consortium . The Annals of Family Medicine vol. 19 , ( 2 ) 135 - 140 .

( 2021 ) . Chronic acid-suppressant use and risk of Oesophageal cancer: protocol for a longitudinal study using a large population based cohort .

Robson J, Garriga C, Coupland C, Hippisley-Cox J ( 2021 ) . NHS Health Checks: an observational study of equity and outcomes 2009–2017 . British Journal of General Practice vol. 71 , ( 710 ) e701 - e710 .

( 2021 ) . PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression .

( 2021 ) . OX2: Understanding the pattern of symptoms for pancreatic neuroendocrine neoplasms (PNENs) to improve the early diagnosis of pancreatic cancer: analysis of the QResearch database .

Persson MSM, Harman KE, Thomas KS, Chalmers JR, Vinogradova Y, Langan SM, Hippisley-Cox J, Gran S ( 2021 ) . Using electronic health records to inform trial feasibility in a rare autoimmune blistering skin disease in England . BMC Medical Research Methodology vol. 21 , ( 1 ) Article 22 ,

( 2021 ) . An external validation of the QCovid risk prediction algorithm for risk of mortality from COVID-19 in adults: national validation cohort study in England .

Hippisley-Cox J, Coupland C ( 2020 ) . Predicting the risk of prostate cancer in asymptomatic men: a cohort study to develop and validate a novel algorithm . British Journal of General Practice vol. 71 , ( 706 ) e364 - e371 .

Pereira S, Hippisley-Cox J, Timms J, Hsuan J, Fusai K, Williams N, Costello E, Greenhalf B et al. ( 2020 ) . ADEPTS (Accelerated Diagnosis of neuroEndocrine and Pancreatic TumourS) and EDRA (Early Diagnosis Research Alliance) . Pancreatology vol. 20 , ( 8 ) e14 - e14 .

Clift AK, Coupland CAC, Hippisley-Cox J ( 2020 ) . Prostate-specific antigen testing and opportunistic prostate cancer screening: a cohort study in England, 1998–2017 . British Journal of General Practice vol. 71 , ( 703 ) e157 - e165 .

Garriga C, Robson J, Coupland C, Hippisley-Cox J ( 2020 ) . NHS Health Checks for people with mental ill-health 2013–2017: an observational study . Epidemiology and Psychiatric Sciences vol. 29 , Article e188 ,

Hippisley-Cox J, Tan PS, Coupland C ( 2020 ) . The Authors’ reply . Heart vol. 107 , ( 1 ) 85.2 - 86 .

Hippisley-Cox J, Tan PS, Coupland C ( 2020 ) . Risk of severe COVID-19 disease with ACE inhibitors and angiotensin receptor blockers: cohort study including 8.3 million people . Heart vol. 107 , ( 2 ) 170.2 - 171 .

Vinogradova Y, Coupland C, Hippisley-Cox J ( 2020 ) . Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases . BMJm3873 - m3873 .

Clift AK, Coupland CAC, Keogh RH, Diaz-Ordaz K, Williamson E, Harrison EM, Hayward A, Hemingway H et al. ( 2020 ) . Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study . BMJm3731 - m3731 .

Garriga C, Robson J, Coupland C, Lay-Flurrie S, Hippisley-Cox J ( 2020 ) . Nationwide health check program by patients with severe mental illness or long-term antidepressants . European Journal of Public Health . vol. 30 ,

Hippisley-Cox J, Young D, Coupland C, Channon KM, Tan PS, Harrison DA, Rowan K, Aveyard P et al. ( 2020 ) . Risk of severe COVID-19 disease with ACE inhibitors and angiotensin receptor blockers: cohort study including 8.3 million people . Heart vol. 106 , ( 19 ) 1503 - 1511 .

Jack RH, Hollis C, Coupland C, Morriss R, Knaggs RD, Butler D, Cipriani A, Cortese S et al. ( 2020 ) . Incidence and prevalence of primary care antidepressant prescribing in children and young people in England, 1998–2017: A population-based cohort study . PLOS Medicine vol. 17 , ( 7 ) e1003215 - e1003215 .

Persson MSM, Harman KE, Vinogradova Y, Langan SM, Hippisley-Cox J, Thomas KS, Gran S ( 2020 ) . Validation study of bullous pemphigoid and pemphigus vulgaris recording in routinely collected electronic primary healthcare records in England . BMJ Open vol. 10 , ( 7 ) e035934 - e035934 .

Hippisley-Cox J, Clift AK, Coupland C, Keogh R, Diaz-Ordaz K, Williamson E, Harrison EM, Hayward A et al. ( 2020 ) . Protocol for the development and evaluation of a tool for predicting risk of short-term adverse outcomes due to COVID-19 in the general UK population .

De Crescenzo F, Garriga C, Tomlinson A, Coupland C, Efthimiou O, Fazel S, Hippisley-Cox J, Cipriani A ( 2020 ) . Real-world effect of antidepressants for depressive disorder in primary care: protocol of a population-based cohort study . Evidence Based Mental Health vol. 23 , ( 3 ) 122 - 126 .

( 2020 ) . Associations between COVID-19 infection, tobacco smoking and nicotine use, common respiratory conditions and inhaled corticosteroids: a prospective QResearch-Case Mix Programme data linkage study January-May 2020 .

( 2020 ) . An integrated polygenic and clinical risk tool enhances coronary artery disease prediction .

Hippisley-Cox J ( 2020 ) . Prediction models for endometrial cancer for the general population or symptomatic women . Critical Reviews in Oncology/Hematology vol. 150 , Article 102712 , 102712 - 102712 .

Jack RH, Joseph RM, Coupland C, Butler D, Hollis C, Morriss R, Knaggs RD, Cipriani A et al. ( 2020 ) . Secondary care specialist visits made by children and young people prescribed antidepressants in primary care: a descriptive study using the QResearch database . BMC Medicine vol. 18 , ( 1 ) Article 93 ,

Persson MSM, Harman KE, Vinogradova Y, Langan SM, Hippisley‐Cox J, Thomas KS, Gran S ( 2020 ) . Incidence, prevalence and mortality of bullous pemphigoid in England 1998–2017: a population‐based cohort study* . British Journal of Dermatology vol. 184 , ( 1 ) 68 - 77 .

Averbeck MA ( 2020 ) . Editorial Comment: Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control . International braz j urol vol. 46 , ( 2 ) 283 - 284 .

Vinogradova Y, Coupland C, Hippisley-Cox J ( 2020 ) . Hormone replacement therapy (HRT) and risk of breast cancer: Nested case-control studies using QResearch and clinical practice research datalink (CPRD) . PHARMACOEPIDEMIOLOGY AND DRUG SAFETY . vol. 29 , 164 - 165 .

Persson MSM, Harman KE, Vinogradova Y, Langan SM, Hippisley-Cox J, Thomas KS, Gran S ( 2020 ) . Incidence, prevalence and mortality of bullous pemphigoid in England 1998-2017: a population-based cohort study . BRITISH JOURNAL OF DERMATOLOGY . vol. 183 , 9 - 10 .

Coupland CAC, Moore M, Hippisley-Cox J ( 2019 ) . Association of Anticholinergic Drug Exposure With Increased Occurrence of Dementia—Reply . JAMA Internal Medicine vol. 179 , ( 12 ) 1730 - 1730 .

Wein AJ ( 2019 ) . Re: Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case Control Study . Journal of Urology vol. 202 , ( 6 ) 1103 - 1104 .

Coupland CAC, Hill T, Dening T, Morriss R, Moore M, Hippisley-Cox J ( 2019 ) . Anticholinergic Drug Exposure and the Risk of Dementia . JAMA Internal Medicine vol. 179 , ( 8 ) 1084 - 1084 .

Morriss R, Coupland C, Hippisley-Cox J, Moore M ( 2019 ) . Safety of antidepressants: suicides, self-harm, cardiovascular, falls and mortality analysis in quarter of million people with newly diagnosed depression aged 20-64 years in United Kingdom . Journal of Affective Disorders vol. 254 , 151 - 151 .

Jack RH, Hollis C, Coupland C, Morriss R, Knaggs RD, Cipriani A, Cortese S, Hippisley-Cox J ( 2019 ) . Trends in antidepressant prescriptions in children and young people in England, 1998–2017: protocol of a cohort study using linked primary care and secondary care datasets . Evidence Based Mental Health vol. 22 , ( 3 ) 129 - 133 .

Vinogradova Y, Coupland C, Hippisley-Cox J ( 2019 ) . Use of hormone replacement therapy and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases . BMJk4810 - k4810 .

Vinogradova Y, Coupland C, Hill T, Hippisley-Cox J ( 2018 ) . Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care . BMJk2505 - k2505 .

Vinogradova Y, Coupland C, Hippisley-Cox J ( 2018 ) . Risk of bleeding with direct oral anticoagulants versus warfarin: cohort studies using primary care datasets . British Journal of General Practice vol. 68 , ( suppl 1 ) bjgp18X696629 - bjgp18X696629 .

Coupland C, Hill T, Morriss R, Moore M, Arthur A, Hippisley-Cox J ( 2018 ) . Antidepressant use and risk of adverse outcomes in people aged 20–64 years: cohort study using a primary care database . BMC Medicine vol. 16 , ( 1 ) Article 36 ,

Vinogradova Y, Coupland C, Hippisley-Cox J, Whyte S, Penny C ( 2018 ) . Effects of severe mental illness on survival of people with diabetes . British Journal of Psychiatry vol. 197 , ( 4 ) 272 - 277 .

Hippisley-Cox J, Coupland C ( 2017 ) . Development and validation of QDiabetes-2018 risk prediction algorithm to estimate future risk of type 2 diabetes: cohort study . BMJj5019 - j5019 .

Hippisley-Cox J, Coupland C ( 2017 ) . Development and validation of QMortality risk prediction algorithm to estimate short term risk of death and assess frailty: cohort study . BMJj4208 - j4208 .

Hippisley-Cox J, Coupland C ( 2017 ) . Development and validation of risk prediction equations to estimate survival in patients with colorectal cancer: cohort study . BMJj2497 - j2497 .

Hippisley-Cox J, Coupland C, Brindle P ( 2017 ) . Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study . BMJj2099 - j2099 .

Hippisley-Cox J ( 2017 ) . Incorporating cancer risk information into general practice: a qualitative study using focus groups with health professionals . British Journal of General Practice vol. 67 , ( 657 ) 158.2 - 158 .

Hippisley-Cox J, Coupland C ( 2016 ) . Diabetes treatments and risk of heart failure, cardiovascular disease, and all cause mortality: cohort study in primary care . BMJi3477 - i3477 .

Vinogradova Y, Coupland C, Brindle P, Hippisley-Cox J ( 2016 ) . Discontinuation and restarting in patients on statin treatment: prospective open cohort study using a primary care database . BMJi3305 - i3305 .

Hippisley-Cox J, Coupland C ( 2016 ) . Diabetes treatments and risk of amputation, blindness, severe kidney failure, hyperglycaemia, and hypoglycaemia: open cohort study in primary care . BMJi1450 - i1450 .

Coupland C, Hill T, Morriss R, Moore M, Arthur A, Hippisley-Cox J ( 2016 ) . Antidepressant use and risk of cardiovascular outcomes in people aged 20 to 64: cohort study using primary care database . BMJi1350 - i1350 .

Robson J, Dostal I, Sheikh A, Eldridge S, Madurasinghe V, Griffiths C, Coupland C, Hippisley-Cox J ( 2016 ) . The NHS Health Check in England: an evaluation of the first 4 years . BMJ Open vol. 6 , ( 1 ) e008840 - e008840 .

Hill T, Coupland C, Morriss R, Arthur A, Moore M, Hippisley-Cox J ( 2015 ) . Antidepressant use and risk of epilepsy and seizures in people aged 20 to 64 years: cohort study using a primary care database . BMC Psychiatry vol. 15 , ( 1 ) Article 315 ,

Hippisley-Cox J, Coupland C ( 2015 ) . Development and validation of risk prediction equations to estimate future risk of blindness and lower limb amputation in patients with diabetes: cohort study . BMJ vol. 351 , ( nov11 1 ) h5441 - h5441 .

Vinogradova Y, Coupland C, Brindle P, Hippisley-Cox J ( 2015 ) . Patients who discontinued statin treatment: a protocol for cohort study using primary care data . BMJ Open vol. 5 , ( 10 ) e008701 - e008701 .

Hippisley-Cox J, Coupland C, Brindle P ( 2015 ) . Concerns on “Validation of a Data Collection Tool and Stroke Risk Predictor” . International Journal of Stroke vol. 10 , ( 7 ) E82 - E82 .

Hippisley-Cox J, Coupland C ( 2015 ) . Development and validation of risk prediction equations to estimate future risk of heart failure in patients with diabetes: a prospective cohort study . BMJ Open vol. 5 , ( 9 ) e008503 - e008503 .

Vinogradova Y, Coupland C, Hippisley-Cox J ( 2015 ) . Authors' reply to Zagarella . BMJ vol. 350 , ( jun24 10 ) h3308 - h3308 .

Hippisley-Cox J ( 2015 ) . Response to Letter on Statin Use and Risk of Cataracts . Journal of Cardiovascular Pharmacology and Therapeutics vol. 21 , ( 2 ) 222 - 222 .

Vinogradova Y, Coupland C, Hippisley-Cox J ( 2015 ) . Use of combined oral contraceptives and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases . BMJ vol. 350 , ( may26 13 ) h2135 - h2135 .

Hippisley-Cox J, Coupland C ( 2015 ) . Development and validation of risk prediction algorithms to estimate future risk of common cancers in men and women: prospective cohort study . BMJ Open vol. 5 , ( 3 ) e007825 - e007825 .

Coupland C, Hill T, Morriss R, Arthur A, Moore M, Hippisley-Cox J ( 2015 ) . Antidepressant use and risk of suicide and attempted suicide or self harm in people aged 20 to 64: cohort study using a primary care database . BMJ vol. 350 , ( feb18 32 ) h517 - h517 .

( 2015 ) . Correction . British Journal of General Practice vol. 65 , ( 631 ) 64 - 64 .

Hankey GJ ( 2014 ) . QBleed predicted risk for gastrointestinal and intracranial bleeding . vol. 161 , is. 12 , pp. JC13 - JC13 . American College of Physicians

Hippisley-Cox J, Coupland C, Brindle P ( 2014 ) . The performance of seven QPrediction risk scores in an independent external sample of patients from general practice: a validation study . BMJ Open vol. 4 , ( 8 ) e005809 - e005809 .

Heath I, Evans S, Furberg C, Hippisley-Cox J, Krumholz H, Mulrow C, Wicks P ( 2014 ) . Report of the independent panel considering the retraction of two articles in The BMJ . BMJ vol. 349 , ( aug14 11 ) g5176 - g5176 .

Hippisley-Cox J, Coupland C ( 2014 ) . Predicting risk of upper gastrointestinal bleed and intracranial bleed with anticoagulants: cohort study to derive and validate the QBleed scores . BMJ vol. 349 , ( jul28 14 ) g4606 - g4606 .

Vinogradova Y, Coupland C, Hippisley-Cox J ( 2014 ) . Exposure to combined oral contraceptives and risk of venous thromboembolism: a protocol for nested case–control studies using the QResearch and the CPRD databases . BMJ Open vol. 4 , ( 4 ) e004499 - e004499 .

Hippisley-Cox J, Coupland C, Robson J, Brindle P ( 2014 ) . QRISK2 validation by ethnic group . Heart vol. 100 , ( 5 ) 436 - 436 .

Hippisley-Cox J, Coupland C ( 2013 ) . Predicting risk of emergency admission to hospital using primary care data: derivation and validation of QAdmissions score . BMJ Open vol. 3 , ( 8 ) e003482 - e003482 .

Vinogradova Y, Coupland C, Hippisley-Cox J ( 2013 ) . Exposure to bisphosphonates and risk of common non-gastrointestinal cancers: series of nested case–control studies using two primary-care databases . British Journal of Cancer vol. 109 , ( 3 ) 795 - 806 .

Hippisley-Cox J, Coupland C ( 2013 ) . Independent external validation of QCancer (Ovarian) . European Journal of Cancer Care vol. 22 , ( 4 ) 559 - 560 .

Coupland C, Morriss R, Arthur A, Moore M, Hill T, Hippisley-Cox J ( 2013 ) . Safety of antidepressants in adults aged under 65: protocol for a cohort study using a large primary care database . BMC Psychiatry vol. 13 , ( 1 ) Article 135 ,

Hippisley-Cox J, Coupland C, Brindle P ( 2013 ) . Derivation and validation of QStroke score for predicting risk of ischaemic stroke in primary care and comparison with other risk scores: a prospective open cohort study . BMJ vol. 346 , ( may02 1 ) f2573 - f2573 .

Vinogradova Y, Coupland C, Hippisley-Cox J ( 2013 ) . Authors' reply to Abrahamsen and colleagues . BMJ vol. 346 , ( mar12 3 ) f1518 - f1518 .

Hippisley-Cox J, Coupland C ( 2013 ) . Symptoms and risk factors to identify people with suspected cancer in primary care . British Journal of General Practice vol. 63 , ( 608 ) 125.2 - 126 .

Vinogradova Y, Coupland C, Hippisley-Cox J ( 2013 ) . Exposure to bisphosphonates and risk of gastrointestinal cancers: series of nested case-control studies with QResearch and CPRD data . BMJ vol. 346 , ( jan16 1 ) f114 - f114 .

Hippisley-Cox J, Coupland C ( 2013 ) . Symptoms and risk factors to identify men with suspected cancer in primary care: derivation and validation of an algorithm . British Journal of General Practice vol. 63 , ( 606 ) e1 - e10 .

Hippisley-Cox J, Coupland C ( 2013 ) . Symptoms and risk factors to identify women with suspected cancer in primary care: derivation and validation of an algorithm . British Journal of General Practice vol. 63 , ( 606 ) e11 - e21 .

Coupland C, Hippisley-Cox J ( 2012 ) . Predicting risk of bladder cancer in the UK . British Journal of General Practice vol. 62 , ( 604 ) 570.3 - 571 .

Robson J, Hippisley‐Cox J, Coupland C ( 2012 ) . QRISK or Framingham? . British Journal of Clinical Pharmacology vol. 74 , ( 3 ) 545 - 546 .

Robson J, Hippisley-Cox J, Brindle P ( 2012 ) . Adding Systematic Family History Enquiry to Cardiovascular Disease Risk Assessment: Clinical Utility in Primary Care . Annals of Internal Medicine vol. 157 , ( 2 ) 148 - 148 .

Robson J, Hippisley-Cox J, Coupland C ( 2012 ) . QRisk superior in diverse South Asian groups . International Journal of Clinical Practice vol. 66 , ( 7 ) 722 - 722 .

Cresswell KM, Sadler S, Rodgers S, Avery A, Cantrill J, Murray SA, Sheikh A ( 2012 ) . An embedded longitudinal multi-faceted qualitative evaluation of a complex cluster randomized controlled trial aiming to reduce clinically important errors in medicines management in general practice . Trials vol. 13 , ( 1 ) Article 78 ,

Hippisley-Cox J, Coupland C ( 2012 ) . Derivation and validation of updated QFracture algorithm to predict risk of osteoporotic fracture in primary care in the United Kingdom: prospective open cohort study . BMJ vol. 344 , ( may22 1 ) e3427 - e3427 .

( 2012 ) . Lifetime Risks of Cardiovascular Disease . New England Journal of Medicine vol. 366 , ( 17 ) 1641 - 1643 .

Hippisley-Cox J, Coupland C ( 2012 ) . Identifying patients with suspected renal tract cancer in primary care: derivation and validation of an algorithm . British Journal of General Practice vol. 62 , ( 597 ) e251 - e260 .

Burtscher M ( 2012 ) . Lifetime risks of cardiovascular disease . The New England journal of medicine vol. 366 , ( 17 )

Hippisley-Cox J, Coupland C, Robson J, Brindle P ( 2012 ) . Atrial fibrillation and rheumatoid arthritis are cardiovascular risk factors . BMJ vol. 344 , ( mar27 2 ) e2259 - e2259 .

Hippisley-Cox J, Coupland C ( 2012 ) . Predictive effect of heartburn and indigestion and risk of upper gastro-intestinal malignancy . British Journal of General Practice vol. 62 , ( 596 ) 124.2 - 126 .

Coloma PM, Trifirò G, Schuemie MJ, Gini R, Herings R, Hippisley‐Cox J, Mazzaglia G, Picelli G et al. ( 2012 ) . Electronic healthcare databases for active drug safety surveillance: is there enough leverage? . Pharmacoepidemiology and Drug Safety vol. 21 , ( 6 ) 611 - 621 .

Berry JD, Dyer A, Cai X, Garside DB, Ning H, Thomas A, Greenland P, Van Horn L et al. ( 2012 ) . Lifetime Risks of Cardiovascular Disease . New England Journal of Medicine vol. 366 , ( 4 ) 321 - 329 .

Vinogradova Y, Coupland C, Hippisley-Cox J ( 2012 ) . Exposure to bisphosphonates and risk of cancer: a protocol for nested case–control studies using the QResearch primary care database . BMJ Open vol. 2 , ( 1 ) e000548 - e000548 .

Hippisley-Cox J, Coupland C ( 2012 ) . Identifying women with suspected ovarian cancer in primary care: derivation and validation of algorithm . BMJ vol. 344 , ( jan04 1 ) d8009 - d8009 .

Hippisley-Cox J, Coupland C ( 2012 ) . Identifying patients with suspected colorectal cancer in primary care: derivation and validation of an algorithm . British Journal of General Practice vol. 62 , ( 594 ) e29 - e37 .

Hippisley-Cox J, Coupland C ( 2012 ) . Identifying patients with suspected pancreatic cancer in primary care: derivation and validation of an algorithm . British Journal of General Practice vol. 62 , ( 594 ) e38 - e45 .

McEvoy JW ( 2012 ) . Lifetime Risks of Cardiovascular Disease . NEW ENGLAND JOURNAL OF MEDICINE vol. 366 , ( 17 ) 1642 - 1642 .

Hippisley-Cox J, Coupland C ( 2011 ) . Identifying patients with suspected gastro-oesophageal cancer in primary care: derivation and validation of an algorithm . British Journal of General Practice vol. 61 , ( 592 ) e707 - e714 .

Hippisley-Cox J, Coupland C ( 2011 ) . Identifying patients with suspected lung cancer in primary care: derivation and validation of an algorithm . British Journal of General Practice vol. 61 , ( 592 ) e715 - e723 .

Vinogradova Y, Coupland C, Hippisley-Cox J ( 2011 ) . Risk of pneumonia in patients taking statins: population-based nested case-control study . British Journal of General Practice vol. 61 , ( 592 ) e742 - e748 .

Vinogradova Y, Coupland C, Hippisley-Cox J ( 2011 ) . Exposure to statins and risk of common cancers: a series of nested case-control studies . BMC Cancer vol. 11 , ( 1 ) Article 409 ,

Hippisley-Cox J, Coupland C ( 2011 ) . Development and validation of risk prediction algorithm (QThrombosis) to estimate future risk of venous thromboembolism: prospective cohort study . BMJ vol. 343 , ( aug16 1 ) d4656 - d4656 .

Trifirò G, Patadia V, Schuemie MJ, Coloma PM, Gini R, Herings R, Hippisley-Cox J, Mazzaglia G et al. ( 2011 ) . EU-ADR healthcare database network vs. spontaneous reporting system database: preliminary comparison of signal detection . Studies in Health Technology and Informatics vol. 166 , 25 - 30 .

Vinogradova Y, Coupland C, Hippisley-Cox J ( 2011 ) . O4-4.4 Exposure to cyclo-oxygenase-2 inhibitors and risk of cancer: nested case-control studies . Journal of Epidemiology &amp; Community Health vol. 65 , ( Suppl 1 ) A44 - A45 .

Coupland C, Dhiman P, Morriss R, Arthur A, Barton G, Hippisley-Cox J ( 2011 ) . Antidepressant use and risk of adverse outcomes in older people: population based cohort study . BMJ vol. 343 , ( aug02 1 ) d4551 - d4551 .

Coupland CAC, Dhiman P, Barton G, Morriss R, Arthur A, Sach T, Hippisley-Cox J ( 2011 ) . A study of the safety and harms of antidepressant drugs for older people: a cohort study using a large primary care database . Health Technology Assessment vol. 15 , ( 28 )

Vinogradova Y, Coupland C, Hippisley-Cox J ( 2011 ) . Exposure to cyclooxygenase-2 inhibitors and risk of cancer: nested case–control studies . British Journal of Cancer vol. 105 , ( 3 ) 452 - 459 .

Logan RF, Vinogradova Y, Coupland CA, Hippisley-Cox J ( 2011 ) . Is Low-Dose Aspirin Use Associated With a Reduced Risk of Colorectal Cancer? A Qresearch Primary Care Database Analysis . Gastroenterology vol. 140 , ( 5 ) S - 402 .

HARCOURT SE, SMITH GE, ELLIOT AJ, PEBODY R, CHARLETT A, IBBOTSON S, REGAN M, HIPPISLEY-COX J ( 2011 ) . Use of a large general practice syndromic surveillance system to monitor the progress of the influenza A(H1N1) pandemic 2009 in the UK . Epidemiology and Infection vol. 140 , ( 1 ) 100 - 105 .

Logan RF, Vinogradova Y, Coupland CA, Hippisley-Cox J ( 2011 ) . Is low-dose aspirin use associated with a reduced risk of colorectal cancer? A QResearch primary care database analysis . Gut vol. 60 , ( Suppl 1 ) A3 - A3 .

Hippisley-Cox J, Coupland C, Robson J, Brindle P ( 2011 ) . Advantages of QRISK2 (2010): the key issue is ethnicity and extent of reallocation . Heart vol. 97 , ( 6 ) 515 - 515 .

Smith S, Smith GE, Olowokure B, Ibbotson S, Foord D, Maguire H, Pebody R, Charlett A et al. ( 2011 ) . Early spread of the 2009 influenza A(H1N1) pandemic in the United Kingdom – use of local syndromic data, May–August 2009 . Eurosurveillance vol. 16 , ( 3 )

Coupland CAC, Dhiman P, Barton G, Morriss R, Arthur A, Sach T, Hippisley-Cox J ( 2011 ) . A study of the safety and harms of antidepressant drugs for older people: a cohort study using a large primary care database . HEALTH TECHNOLOGY ASSESSMENT vol. 15 , ( 28 ) 1 - + .

Smith S, Smith GE, Olowokure B, Ibbotson S, Foord D, Maguire H, Pebody R, Charlett A et al. ( 2011 ) . Early spread of the 2009 influenza A(H1N1) pandemic in the United Kingdom--use of local syndromic data, May-August 2009 . Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin vol. 16 , ( 3 )

Coloma PM, Trifiro G, Schuemie M, Gini R, Herings R, Hippisley-Cox J, Mazzaglia G, Corrao G et al. ( 2011 ) . For How Many and What Types of Drugs Can Longitudinal Healthcare Databases Detect Safety Signals? A View from the EU-ADR Project . PHARMACOEPIDEMIOLOGY AND DRUG SAFETY . vol. 20 , S160 - S160 .

Trifiro' G, Avillach P, Gini R, Coloma P, Mazzaglia G, Picelli G, Scotti L, Herings R et al. ( 2011 ) . Harmonization of the Event Identification Process in Eight European Healthcare Databases: The Experience from the EU-ADR Project . PHARMACOEPIDEMIOLOGY AND DRUG SAFETY . vol. 20 , S4 - S4 .

Logan RE, Vinogradova Y, Coupland CA, Hippisley-Cox J ( 2011 ) . Is Low-Dose Aspirin Use Associated With a Reduced Risk of Colorectal Cancer? A Qresearch Primary Care Database Analysis . GASTROENTEROLOGY . vol. 140 , S402 - S402 .

Hippisley-Cox J, Coupland C, Robson J, Brindle P ( 2010 ) . Derivation, validation, and evaluation of a new QRISK model to estimate lifetime risk of cardiovascular disease: cohort study using QResearch database . BRIT MED J vol. 341 , Article c6624 ,

Hippisley-Cox J, Coupland C, Robson J, Brindle P ( 2010 ) . Derivation, validation, and evaluation of a new QRISK model to estimate lifetime risk of cardiovascular disease: cohort study using QResearch database . BMJ (Clinical research ed.) vol. 341 ,

Coloma PM, Schuemie MJ, Trifirò G, Gini R, Herings R, Hippisley‐Cox J, Mazzaglia G, Giaquinto C et al. ( 2010 ) . Combining electronic healthcare databases in Europe to allow for large‐scale drug safety monitoring: the EU‐ADR Project . Pharmacoepidemiology and Drug Safety vol. 20 , ( 1 ) 1 - 11 .

Parker C, Coupland C, Hippisley-Cox J ( 2010 ) . Antipsychotic drugs and risk of venous thromboembolism: nested case-control study . BMJ vol. 341 , ( sep21 1 ) c4245 - c4245 .

Smith S, Elliot AJ, Mallaghan C, Modha D, Hippisley-Cox J, Large S, Regan M, Smith GE ( 2010 ) . Value of syndromic surveillance in monitoring a focal waterborne outbreak due to an unusual Cryptosporidium genotype in Northamptonshire, United Kingdom, June-July 2008 . EUROSURVEILLANCE vol. 15 , ( 33 ) Article 19643 ,

Simpson CR, Hippisley-Cox J, Sheikh A ( 2010 ) . Trends in the epidemiology of chronic obstructive pulmonary disease in England: a national study of 51 804 patients . British Journal of General Practice vol. 60 , ( 576 ) e277 - e284 .

Hippisley-Cox J, Coupland C ( 2010 ) . Predicting the risk of Chronic Kidney Disease in Men and Women in England and Wales: prospective derivation and external validation of the QKidney®Scores . BMC Family Practice vol. 11 , ( 1 ) Article 49 ,

Hippisley-Cox J, Coupland C ( 2010 ) . Individualising the risks of statins in men and women in England and Wales: population-based cohort study . Heart vol. 96 , ( 12 ) 939 - 947 .

Hippisley-Cox J, Coupland C ( 2010 ) . Unintended effects of statins in men and women in England and Wales: population based cohort study using the QResearch database . BMJ vol. 340 , ( may19 4 ) c2197 - c2197 .

Vinogradava Y, Leighton M, Hippisley-Cox J, Hawkey CJ ( 2010 ) . 737 Continuing Undue Risks in UK Prescribing of Non-Steroidal Anti-Inflammatory Drugs . Gastroenterology vol. 138 , ( 5 ) S - 100 .

Chisholm D, Stanciole AE, Tan Torres Edejer T, Evans DB ( 2010 ) . Economic impact of disease and injury: counting what matters . BMJ vol. 340 , ( mar02 1 ) c924 - c924 .

Simpson CR, Hippisley-Cox J, Sheikh A ( 2010 ) . Trends in the epidemiology of smoking recorded in UK general practice . British Journal of General Practice vol. 60 , ( 572 ) e121 - e127 .

Vinogradava Y, Leighton M, Hippisley-Cox J, Hawkey CJ ( 2010 ) . Continuing Undue Risks in UK Prescribing of Non-Steroidal Anti-Inflammatory Drugs . GASTROENTEROLOGY . vol. 138 , S100 - S100 .

Avillach Paul, Joubert Michel, Thiessard Frantz, Trifir&ograve; Gianluca, Dufour Jean-Charles, Pariente Antoine, Mougin Fleur, Polimeni Giovanni et al. ( 2010 ) . Design and evaluation of a semantic approach for the homogeneous identification of events in eight patient databases: a contribution to the European EU-ADR project .

Avillach P, Joubert M, Thiessard F, Trifirò G, Dufour J-C, Pariente A, Mougin F, Polimeni G et al. ( 2010 ) . Design and evaluation of a semantic approach for the homogeneous identification of events in eight patient databases: a contribution to the European EU-ADR project . Studies in health technology and informatics vol. 160 , ( Pt 2 ) 1085 - 1089 .

Gini R, Avillach P, Coloma PM, Mougin F, Dufour J-C, Thiessard F, Joubert M, Mazzaglia G et al. ( 2010 ) . HARMONISING DEFINITIONS OF ADVERSE EVENTS AMONG 8 EUROPEAN HEALTHCARE DATABASES PARTICIPATING IN THE EU-ADR PROJECT . EPIDEMIOLOGIA & PREVENZIONE . vol. 34 , 89 - 90 .

Coloma P, Trifiro' G, Schuemie M, Gini R, Herings R, Hippisley-Cox J, Mazzaglia G, Corrao G et al. ( 2010 ) . Psychotropic Drug Use in the Elderly Across Europe: A Perspective from the EU-ADR Project . PHARMACOEPIDEMIOLOGY AND DRUG SAFETY . vol. 19 , S230 - S230 .

Simpson CR, Hippisley-Cox J, Sheikh A ( 2010 ) . Trends in the epidemiology of smoking recorded in UK general practice . The British journal of general practice : the journal of the Royal College of General Practitioners vol. 60 , ( 572 )

Hippisley-Cox J, Coupland C ( 2009 ) . Predicting risk of osteoporotic fracture in men and women in England and Wales: prospective derivation and validation of QFractureScores . BMJ vol. 339 , ( nov19 1 ) b4229 - b4229 .

Vinogradova Y, Hippisley-Cox J, Coupland C ( 2009 ) . Identification of new risk factors for pneumonia: population-based case-control study . British Journal of General Practice vol. 59 , ( 567 ) e329 - e338 .

Trifirò G, Pariente A, Coloma PM, Kors JA, Polimeni G, Miremont‐Salamé G, Catania MA, Salvo F et al. ( 2009 ) . Data mining on electronic health record databases for signal detection in pharmacovigilance: which events to monitor? . Pharmacoepidemiology and Drug Safety vol. 18 , ( 12 ) 1176 - 1184 .

Vinogradova Y, Leighton M, Avery A, Logan RF, Kendrick D, Atherton JC, Shonde A, Hippisley-Cox J et al. ( 2009 ) . 408 Increased Aspirin Use and Upper Gastrointestinal Bleeding Rates in Socially Deprived Patients . Gastroenterology vol. 136 , ( 5 ) A - 69 .

Leighton M, Vinogradova Y, Shonde A, Atherton JC, Logan RF, Avery A, Kendrick D, Hippisley-Cox J et al. ( 2009 ) . T1973 Diagnostic Precision of Primary Care Electronic Database for Study of Gastrointestinal Bleeding and Its Ability to Detect the Influence of Aspirin . Gastroenterology vol. 136 , ( 5 ) A - 612 .

Simpson CR, Newton J, Hippisley-Cox J, Sheikh A ( 2009 ) . Trends in the epidemiology and prescribing of medication for eczema in England . Journal of the Royal Society of Medicine vol. 102 , ( 3 ) 108 - 117 .

Hippisley-Cox J, Coupland C, Robson J, Sheikh A, Brindle P ( 2009 ) . Predicting risk of type 2 diabetes in England and Wales: prospective derivation and validation of QDScore . BRIT MED J vol. 338 , Article b880 ,

Hippisley-Cox J, Coupland C, Robson J, Sheikh A, Brindle P ( 2009 ) . Predicting risk of type 2 diabetes in England and Wales: prospective derivation and validation of QDScore . BMJ (Clinical research ed.) vol. 338 ,

Avillach Paul, Mougin Fleur, Joubert Michel, Thiessard Frantz, Pariente Antoine, Dufour Jean-Charles, Trifir&ograve; Gianluca, Polimeni Giovanni et al. ( 2009 ) . A Semantic Approach for the Homogeneous Identification of Events in Eight Patient Databases: A Contribution to the European eu-ADR Project .

Sheikh A, Hippisley-Cox J, Newton J, Fenty J ( 2009 ) . Anaphylaxis epidemic: Fact or fiction? (vol 122, pg 1166, 2008) . JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY vol. 123 , ( 5 ) 1195 - 1195 .

Leighton M, Vivogravada Y, Shonde A, Atherton JC, Logan RFA, Avery A, Kendrick D, Hippisley-Cox J et al. ( 2009 ) . DIAGNOSTIC PRECISION OF PRIMARY CARE ELECTRONIC DATABASE FOR STUDY OF GASTROINTESTINAL BLEEDING AND ITS ABILITY TO DETECT THE INFLUENCE OF ASPIRIN . GUT . vol. 58 , A139 - A139 .

Trifiro G, Pariente A, Coloma PM, Kors JA, Polimeni G, Miremont-Salame G, Catania MA, Salvo F et al. ( 2009 ) . Data Mining on Electronic Health Record Databases for Signal Detection in Pharmacovigilance: Which Events To Monitor? . PHARMACOEPIDEMIOLOGY AND DRUG SAFETY . vol. 18 , S212 - S212 .

Leighton M, Vinogradova Y, Shonde A, Atherton JC, Logan RF, Avery A, Kendrick D, Hippisley-Cox J et al. ( 2009 ) . Diagnostic Precision of Primary Care Electronic Database for Study of Gastrointestinal Bleeding and Its Ability to Detect the Influence of Aspirin . GASTROENTEROLOGY . vol. 136 , A612 - A612 .

Vinogradova Y, Leighton M, Avery A, Logan RF, Kendrick D, Atherton JC, Shonde A, Hippisley-Cox J et al. ( 2009 ) . Increased Aspirin Use and Upper Gastrointestinal Bleeding Rates in Socially Deprived Patients . GASTROENTEROLOGY . vol. 136 , A69 - A69 .

Coloma P, Schuemie M, Trifiro' G, Herings R, Hippisley-Cox J, Gini R, Molokhia M, Mazagglia G et al. ( 2009 ) . Opportunity in Diversity: Merging Healthcare Databases in Europe for Safety Signal Detection in Pharmacovigilance . PHARMACOEPIDEMIOLOGY AND DRUG SAFETY . vol. 18 , S184 - S184 .

Simpson CR, Newton J, Hippisley-Cox J, Sheikh A ( 2008 ) . Incidence and prevalence of multiple allergic disorders recorded in a national primary care database . Journal of the Royal Society of Medicine vol. 101 , ( 11 ) 558 - 563 .

Ghouri N, Hippisley-Cox J, Newton J, Sheikh A ( 2008 ) . Trends in the epidemiology and prescribing of medication for allergic rhinitis in England . Journal of the Royal Society of Medicine vol. 101 , ( 9 ) 466 - 472 .

Hippisley-Cox J, Coupland C, Vinogradova Y, Robson J, Minhas R, Sheikh A, Brindle P ( 2008 ) . Predicting cardiovascular risk in England and Wales: prospective derivation and validation of QRISK2 . BRIT MED J vol. 336 , ( 7659 ) 1475 - + .

Holt TA, Stables D, Hippisley-Cox J, O'Hanlon S, Majeed A ( 2008 ) . Identifying undiagnosed diabetes: cross-sectional survey of 3.6 million patients' electronic records . British Journal of General Practice vol. 58 , ( 548 ) 192 - 196 .

Sheikh A, Hippisley-Cox J, Newton J, Fenty J ( 2008 ) . Trends in national incidence, lifetime prevalence and adrenaline prescribing for anaphylaxis in England . Journal of the Royal Society of Medicine vol. 101 , ( 3 ) 139 - 143 .

Bayly JR, Potter J, Fenty J, Parker C, Masud T, Hippisley-Cox J ( 2008 ) . Managing osteoporosis in UK general practice: Results from a national evaluation using the QRESEARCH database . CALCIFIED TISSUE INTERNATIONAL . vol. 82 , S213 - S213 .

Hippisley-Cox J, Coupland C, Vinogradova Y, Robson J, Brindle P ( 2008 ) . Performance of the QRISK cardiovascular risk prediction algorithm in an independent UK sample of patients from general practice: a validation study . HEART vol. 94 , ( 1 ) 34 - 39 .

Hippisley-Cox J, Vinogradova Y, Coupland C, Parker C ( 2007 ) . Risk of Malignancy in Patients With Schizophrenia or Bipolar Disorder . Archives of General Psychiatry vol. 64 , ( 12 ) 1368 - 1368 .

Whyte S, Penny C, Phelan M, Hippisley‐Cox J, Majeed A ( 2007 ) . Quality of diabetes care in patients with schizophrenia and bipolar disorder: cross‐sectional study . Diabetic Medicine vol. 24 , ( 12 ) 1442 - 1448 .

Heath I, Hippisley-Cox J, Smeeth L ( 2007 ) . Measuring performance and missing the point? . BMJ vol. 335 , ( 7629 ) 1075 - 1076 .

Hippisley-Cox J, Parker C, Coupland C, Vinogradova Y ( 2007 ) . Inequalities in the primary care of patients with coronary heart disease and serious mental health problems: a cross-sectional study . Heart vol. 93 , ( 10 ) 1256 - 1262 .

Coupland C, Harcourt S, Vinogradova Y, Smith G, Joseph C, Pringle M, Hippisley-Cox J ( 2007 ) . Inequalities in uptake of influenza vaccine by deprivation and risk group: Time trends analysis . Vaccine vol. 25 , ( 42 ) 7363 - 7371 .

Vinogradova Y, Hippisley–Cox J, Coupland C, Logan RF ( 2007 ) . Risk of Colorectal Cancer in Patients Prescribed Statins, Nonsteroidal Anti-Inflammatory Drugs, and Cyclooxygenase-2 Inhibitors: Nested Case-Control Study . Gastroenterology vol. 133 , ( 2 ) 393 - 402 .

Hippisley-Cox J, Coupland C, Vinogradova Y, Robson J, May M, Brindle P ( 2007 ) . Derivation and validation of QRISK, a new cardiovascular disease risk score for the United Kingdom: prospective open cohort study . BRIT MED J vol. 335 , ( 7611 ) 136 - 141 .

Davies SJC, Jackson PR, Ramsay LE, Ghahramani P, Palmer RL, Hippisley‐Cox J ( 2007 ) . No Evidence That Panic Attacks Are Associated With the White Coat Effect in Hypertension . The Journal of Clinical Hypertension vol. 5 , ( 2 ) 145 - 152 .

Parker C, Hippisley-Cox J, Coupland C, Vinogradova Y ( 2007 ) . Rectal and postmenopausal bleeding: Consultation and referral of patients with and without severe mental health problems . British Journal of General Practice vol. 57 , ( 538 ) 371 - 376 .

PEBODY RG, HIPPISLEY-COX J, HARCOURT S, PRINGLE M, PAINTER M, SMITH G ( 2007 ) . Uptake of pneumococcal polysaccharide vaccine in at-risk populations in England and Wales 1999–2005 . Epidemiology and Infection vol. 136 , ( 3 ) 360 - 369 .

Bethea J, Hippisley-Cox J, Coupland C, Pringle M ( 2007 ) . General practitioners' attitudes towards the provision of services to young people aged under 16: A cross-sectional survey . Quality in Primary Care vol. 15 , ( 1 ) 11 - 19 .

Smith G, Hippisley-Cox J, Harcourt S, Heaps M, Painter M, Porter A, Pringle M ( 2006 ) . Developing a national primary care-based early warning system for health protection—a surveillance tool for the future? Analysis of routinely collected data . Journal of Public Health vol. 29 , ( 1 ) 75 - 82 .

Coupland C, Hippisley-Cox J, Smith S, Irving W, Pringle M, Ryder S, Neal K, Cater R et al. ( 2006 ) . General practice characteristics associated with rates of testing and detection of hepatitis C: cross-sectional study in Nottingham and Derbyshire . BRIT J GEN PRACT vol. 56 , ( 529 ) 620 - 623 .

Hippisley-Cox J, Smith S, Smith GE, Porter A, Heaps M, Holland R, Fenty J, Harcourt S et al. ( 2006 ) . QFLU: new influenza monitoring in UK primary care to support pandemic influenza planning . Weekly releases (1997–2007) vol. 11 , ( 25 )

Groom L, Kendrick D, Coupland C, Patel B, Hippisley-Cox J ( 2006 ) . Inequalities in hospital admission rates for unintentional poisoning in young children . Injury Prevention vol. 12 , ( 3 ) 166 - 170 .

Hippisley-Cox J, Yates J, Pringle M, Coupland C, Hammersley V ( 2006 ) . Sex inequalities in access to care for patients with diabetes in primary care: Questionnaire survey . British Journal of General Practice vol. 56 , ( 526 ) 342 - 348 .

Hippisley-Cox J, Coupland C ( 2006 ) . Erratum: Effect of combinations of drugs on all cause mortality in patients with ischaemic heart disease: Nested case-control analysis (British Medical Journal (May 7, 2005) 330 (1059-1063)) . British Medical Journal vol. 332 , ( 7546 )

Irving WL, Smith S, Cater R, Pugh S, Neal KR, Coupland CAC, Ryder SD, Thomson BJ et al. ( 2006 ) . Clinical pathways for patients with newly diagnosed hepatitis C - What actually happens . J VIRAL HEPATITIS vol. 13 , ( 4 ) 264 - 271 .

Hippisley-Cox J, Coupland C ( 2006 ) . Effect of combinations of drugs on all cause mortality in patients with ischaemic heart disease: nested case-control analysis (vol 330, pg 1059, 2005) . BRITISH MEDICAL JOURNAL vol. 332 , ( 7546 ) 912 - 912 .

Hippisley-Cox J, Coupland C, Logan R ( 2005 ) . Risk of adverse gastrointestinal outcomes in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis . BMJ vol. 331 , ( 7528 ) 1310 - 1316 .

Hippisley-Cox J ( 2005 ) . Effect of statins on the mortality of patients with ischaemic heart disease: population based cohort study with nested case-control analysis . Heart vol. 92 , ( 6 ) 752 - 758 .

Hippisley-Cox J, Coupland C ( 2005 ) . Effect of Combinations of Drugs on All-Cause Mortality in Patients With Ischemic Heart Disease: Nested Case-control Analysis . ACC Current Journal Review vol. 14 , ( 8 ) 3 - 3 .

Wilson A, Hippisley-Cox J, Coupland C, Coleman T, Britton J, Barrett S ( 2005 ) . Smoking cessation treatment in primary care: prospective cohort study . Tobacco Control vol. 14 , ( 4 ) 242 - 246 .

Hippisley-Cox J, Coupland C ( 2005 ) . Drug combinations and all cause mortality in heart disease: Authors' reply . BMJ vol. 331 , ( 7509 ) 160.1 - 160.1 .

Hippisley-Cox J, Coupland C ( 2005 ) . Risk of myocardial infarction in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: Population based nested case-control analysis . British Medical Journal vol. 330 , ( 7504 ) 1366 - 1369 .

Hippisley-Cox J, Coupland C ( 2005 ) . Risk of myocardial infarction in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis . BMJ vol. 330 , ( 7504 ) 1366 - 1366 .

Kroese WLG, Avery AJ, Savelyich BSP, Brown NS, Schers H, Howard R, Hippisley-Cox J, Horsfield P ( 2005 ) . Assessing the accuracy of a computerized decision support system for digoxin dosing in primary care: an observational study . Journal of Clinical Pharmacy and Therapeutics vol. 30 , ( 3 ) 279 - 283 .

Hippisley-Cox J, Coupland C ( 2005 ) . Effect of combinations of drugs on all cause mortality in patients with ischaemic heart disease: nested case-control analysis . BMJ vol. 330 , ( 7499 ) 1059 - 1063 .

Hippisley-Cox J, Pringle M, Cater R, Coupland C, Meal A ( 2005 ) . Coronary heart disease prevention and age inequalities: The first year of the National Service Framework for CHD . British Journal of General Practice vol. 55 , ( 514 ) 369 - 375 .

Coupland CAC, Savelyich BSP, Hippisley-Cox J, Kendrick D, Groom L, Cross E ( 2005 ) . A randomized controlled trial of the effect of providing information on accidental injury admissions and their costs to Primary Care Groups and Trusts . Family Practice vol. 22 , ( 3 ) 249 - 252 .

West J, Hippisley-Cox J, Coupland CAC, Price GM, Groom LM, Kendrick D, Webber E ( 2004 ) . Do rates of hospital admission for falls and hip fracture in elderly people vary by socio-economic status? . Public Health vol. 118 , ( 8 ) 576 - 581 .

Hippisley-Cox J ( 2004 ) . Association of deprivation, ethnicity, and sex with quality indicators for diabetes: population based survey of 53 000 patients in primary care . BMJ vol. 329 , ( 7477 ) 1267 - 1269 .

Hippisley-Cox J, O'Hanlon S, Coupland C ( 2004 ) . Association of deprivation, ethnicity, and sex with quality indicators for diabetes: population based survey of 53 000 patients in primary care . BMJ vol. 329 , ( 7477 ) 1267 - 1269 .

Meal A, Wynn A, Pringle M, Cater R, Hippisley-Cox J ( 2004 ) . Learning by heart: An interview study in general practice during the advent of the National Service Framework for coronary heart disease . Quality in Primary Care vol. 12 , ( 3 ) 179 - 184 .

Hippisley-Cox J, Pringle M ( 2004 ) . Prevalence, care, and outcomes for patients with diet-controlled diabetes in general practice: cross sectional survey . The Lancet vol. 364 , ( 9432 ) 423 - 428 .

Hippisley-Cox J ( 2004 ) . Inequalities in access to care for patients with ischemic heart disease . British Journal of General Practice vol. 54 , ( 503 ) 411 - 412 .

Hippisley-Cox J, Hammersley V, Pringle M, Coupland C, Crown N, Wright L ( 2004 ) . Methodology for Assessing the Usefulness of General Practice Data for Research in One Research Network . Health Informatics Journal vol. 10 , ( 2 ) 91 - 109 .

Meal A, Wynn A, Pringle M, Cater R, Hippisley-Cox J ( 2004 ) . Forging links: Evolving attitudes of clinical governance leads in general practice . Quality in Primary Care vol. 12 , ( 1 ) 59 - 64 .

Groom L, Hippisley-Cox J, Kendrick D ( 2004 ) . Primary care organization board members' views on accident prevention . Primary Health Care Research and Development vol. 5 , ( 2 ) 135 - 144 .

Hippisley-Cox J, Stables D, Pringle M ( 2004 ) . QRESEARCH: a new general practice database for research . Journal of Innovation in Health Informatics vol. 12 , ( 1 ) 49 - 50 .

Hippisley-Cox J, Pringle M, Cater R, Wynn A, Hammersley V, Coupland C ( 2003 ) . The use of patient group directions for zanamivir in 2000/2001: Cross-sectional survey of primary care organisations in England . Quality in Primary Care vol. 11 , ( 2 ) 97 - 106 .

Allen J, Hippisley-Cox J, Pringle M, Groom L ( 2003 ) . Assisted delivery in the teenage population: The effect of inter-hospital variation, deprivation, and age . International Journal of Adolescent Medicine and Health vol. 15 , ( 4 )

Hippisley-Cox J ( 2003 ) . Electronic patient records in primary care . BMJ vol. 327 , ( 7415 )

Hippisley-Cox J ( 2003 ) . Electronic patient records in primary care: Author's reply . BMJ vol. 327 , ( 7415 )

Shaw NT ( 2003 ) . Electronic patient records in primary care: Study has serious flaw . BMJ vol. 327 , ( 7415 )

Coupland C ( 2003 ) . Severe traffic injuries to children, Trent, 1992-7: time trend analysis . BMJ vol. 327 , ( 7415 ) 593 - 594 .

( 2003 ) . Effectiveness of lipid lowering drugs in general practice : Authors' reply . BMJ (Clinical research ed.) vol. 327 , ( 7405 ) 51 - 51 .

Hippisley-Cox J, Pringle M, Coupland C ( 2003 ) . Effectiveness of lipid lowering drugs in general practice . BMJ vol. 327 , ( 7405 )

Hippisley-Cox J ( 2003 ) . The electronic patient record in primary care--regression or progression? A cross sectional study . BMJ vol. 326 , ( 7404 ) 1439 - 1443 .

Kendrick D ( 2003 ) . Accidental injury: a neglected area within Primary Care Groups and Trusts? . Health Education Research vol. 18 , ( 3 ) 380 - 388 .

Hippisley-Cox J ( 2003 ) . Cross sectional survey of effectiveness of lipid lowering drugs in reducing serum cholesterol concentration in patients in 17 general practices . BMJ vol. 326 , ( 7391 ) 689 - 689 .

Hippisley-Cox J, Pringle M, Crown N, Coupland C ( 2003 ) . A case-control study on the effect of hormone replacement therapy on ischaemic heart disease . British Journal of General Practice vol. 53 , ( 488 ) 191 - 196 .

Hippisley-Cox J ( 2003 ) . This week in the BMJ: Paperless records are better than traditional system (vol 327, pg 1439, 2003) . BMJ-BRITISH MEDICAL JOURNAL vol. 327 , ( 7413 ) 483 - 483 .

Hippisley-Cox J ( 2002 ) . Married couples' risk of same disease: cross sectional study . BMJ vol. 325 , ( 7365 ) 636 - 636 .

Hippisley-Cox J, Pringle M, Coupland C, Cater R ( 2002 ) . Waiting times for surgery - Inheritance for primary care organisations in Trent . Journal of Clinical Governance vol. 10 , ( 2 ) 63 - 69 .

Hammersley VS, Hippisley-Cox J, Wilson A, Pringle M ( 2002 ) . A comparison of research general practices and their patients with other practices - A cross-sectional survey in trent . British Journal of General Practice vol. 52 , ( 479 ) 463 - 468 .

Hippisley-Cox J ( 2002 ) . Cross sectional survey of socioeconomic variations in severity and mechanism of childhood injuries in Trent 1992-7 . BMJ vol. 324 , ( 7346 ) 1132 - 1132 .

Churchill D, Allen J, Pringle M, Hippisley-Cox J ( 2002 ) . Teenagers at risk of unintended pregnancy: identification of practical risk markers for use in general practice from a retrospective analysis of case records in the United Kingdom . International Journal of Adolescent Medicine and Health vol. 14 , ( 2 )

Hippisley-Cox J, Pringle M, Hammersley V, Crown N, Wynn A, Meal A, Coupland C ( 2001 ) . Antidepressants as risk factor for ischaemic heart disease: case-control study in primary care . BMJ vol. 323 , ( 7314 ) 666 - 669 .

Hippisley-Cox J, Pringle M, Coupland C, Hammersley V, Wilson A ( 2001 ) . Do single handed practices offer poorer care? Cross sectional survey of processes and outcomes . BMJ vol. 323 , ( 7308 ) 320 - 323 .

Hippisley-Cox J, Pringle M ( 2001 ) . General practice workload implications of the national service framework for coronary heart disease: cross sectional survey . BMJ vol. 323 , ( 7307 ) 269 - 270 .

Hippisley-Cox J ( 2001 ) . Sex inequalities in ischaemic heart disease in general practice: cross sectional survey . BMJ vol. 322 , ( 7290 ) 832 - 832 .

Leung WC, Duffield K, Josen PK, Low E, Teare K, Wray E, Churchill D, Allen J et al. ( 2001 ) . Contraception in general practice before teenage pregnancy . BMJ vol. 322 , ( 7282 )

Churchill D, Allen J, Pringle M, Hippisley-Cox J, Ebdon D, Macpherson M, Bradley S ( 2001 ) . Contraception in general practice before teenage pregnancy - Reply . BRITISH MEDICAL JOURNAL vol. 322 , ( 7282 ) 363 - 363 .

Anderson J, Baum M, Bero LA, Chalmers I, Chapman S, Deary IJ, Ebrahim S, Evans M et al. ( 2000 ) . Music to be born to, music to die to . BMJ vol. 321 , ( 7276 ) 1577 - 1579 .

Allen J, Hippisley-Cox J ( 2000 ) . Teenage pregnancy in the UK: Where are we going wrong? . International Journal of Adolescent Medicine and Health vol. 12 , ( 4 )

Hippisley-Cox J, Pringle M ( 2000 ) . The cost-effectiveness of lipid lowering in patients with ischaemic heart disease: An intervention and evaluation in primary care . British Journal of General Practice vol. 50 , ( 458 ) 699 - 705 .

Hippisley-Cox J, Pringle M ( 2000 ) . Inequalities in access to coronary angiography and revascularisation: The association of deprivation and location of primary care services . British Journal of General Practice vol. 50 , ( 455 ) 449 - 454 .

Churchill D ( 2000 ) . Consultation patterns and provision of contraception in general practice before teenage pregnancy: case-control study . BMJ vol. 321 , ( 7259 ) 486 - 489 .

Gbolade BA, Leung WC, Bland M, Hippisley-Cox J ( 2000 ) . Teenage pregnancy rates and the age and sex of general practitioners . BMJ vol. 321 , ( 7257 )

Gbolade BA, Leung WC, Bland M, Hippisley-Cox J ( 2000 ) . Teenage pregnancy rates and the age and sex of general practitioners (multiple letters) . British Medical Journal vol. 321 , ( 7257 ) 381 - 383 .

Hippisley-Cox J ( 2000 ) . Association between teenage pregnancy rates and the age and sex of general practitioners: cross sectional survey in Trent 1994-7 . BMJ vol. 320 , ( 7238 ) 842 - 845 .

Cates C, Wilcock M, Hippisley-Cox J, Pringle M ( 2000 ) . A vote of no confidence in the precision of the estimated cost-effectiveness of lipid lowering (multiple letters) . British Journal of General Practice vol. 50 , ( 460 ) 917 - 918 .

Hippisley-Cox J, Pringle M ( 2000 ) . A vote of no confidence in the precision of the estimated cost-effectiveness of lipid lowering - In response .. . BRITISH JOURNAL OF GENERAL PRACTICE vol. 50 , ( 460 ) 918 - 918 .

Davies SJC, Ghahramani P, Jackson PR, Noble W, Hardy PG, Hippisley-Cox J, Yeo WW, Ramsay LE et al. ( 2000 ) . Asociación entre los trastornos de pánico y ataques de pánico y la hipertensión . Hipertensión y Riesgo Vascular vol. 17 , ( 2 ) 73 - 74 .

Hippisley-Cox J ( 2000 ) . Association between teenage pregnancy rates and the age and sex of general practitioners: cross sectional survey in Trent 1994-7 (vol 320, pg 842, 2000) . BRITISH MEDICAL JOURNAL vol. 320 , ( 7247 ) 1436 - 1436 .

Hippisley-Cox J ( 2000 ) . Teenage pregnancy rates and the age and sex of general practitioners - Reply . BRITISH MEDICAL JOURNAL vol. 321 , ( 7257 ) 382 - 383 .

Davies SJC, Ghahramani P, Jackson PR, Noble TW, Hardy PG, Hippisley-Cox J, Yeo WW, Ramsay LE ( 1999 ) . Association of panic disorder and panic attacks with hypertension . The American Journal of Medicine vol. 107 , ( 4 ) 310 - 316 .

Kendrick T, Earnshaw G, Hippisley-Cox J, Pringle M ( 1998 ) . Depression as a risk factor for ischaemic heart disease in men . BMJ vol. 317 , ( 7170 ) 1450 - 1450 .

Kendrick T, Earnshaw G, Hippisley-Cox J, Pringle M ( 1998 ) . Depression as a risk factor for ischaemic heart disease in men (multiple letters) [2] . British Medical Journal vol. 317 , ( 7170 ) 1450 - 1451 .

Hippisley-Cox J, Fielding K, Pringle M ( 1998 ) . DEPRESSION AND RISK OF CORONARY HEART DISEASE . Southern Medical Journal vol. 91 , ( 11 ) 1085 - 1086 .

Hippisley-Cox J, Pringle M ( 1998 ) . Are spouses of patients with hypertension at increased risk of having hypertension? A population-based case-control study . British Journal of General Practice vol. 48 , ( 434 ) 1580 - 1583 .

Inwald AC, Hippisley-Cox J, Hippisley-Cox S, Hill-Smith I ( 1998 ) . Ethical dilemma: Competency, consent, and the duty of care   Best of motives, worst of consequences   Let the courts decide   The only failure was the outcome . BMJ vol. 317 , ( 7161 ) 809 - 809 .

Hippisley-Cox J, Hippisley-Cox S ( 1998 ) . Let the courts decide . vol. 317 , is. 7161 , pp. 809 - 810 .

Hippisley-Cox J ( 1998 ) . Correction: Depression as a risk factor for ischaemic heart disease in men: Population based case-control study (British Medical Journal (1998) (1714-1719)) . British Medical Journal vol. 317 , ( 7152 )

Hippisley-Cox J, Fielding K, Pringle M ( 1998 ) . Depression as a risk factor for ischaemic heart disease in men: population based case-control study . BMJ vol. 316 , ( 7146 ) 1714 - 1719 .

DAVIES S ( 1998 ) . Panic attacks and panic disorder in hypertension: An important association often overlooked . American Journal of Hypertension vol. 11 , ( 4 ) 21A - 21A .

Hippisley-Cox J, Pringle M ( 1998 ) . Depression as a risk factor for ischaemic heart disease in men - Key assumption about control group undermines study's validity - Reply . BRITISH MEDICAL JOURNAL vol. 317 , ( 7170 ) 1451 - 1451 .

Hippisley-Cox J ( 1998 ) . Depression as a risk factor for ischaemic heart disease in men: population based case-control study (vol 317, pg 1714, 1998) . BRITISH MEDICAL JOURNAL vol. 317 , ( 7152 ) 185 - 185 .

Davies SJC, Ghahramani P, Palmer RL, Hippisley-Cox J, Jackson PR, Yeo WW, Ramsay LE ( 1998 ) . Does white-coat effect contribute to treatment resistance in hypertension? . JOURNAL OF HYPERTENSION . vol. 16 , S209 - S209 .

Hippisley-Cox J, Hardy C, Pringle M, Fielding K, Carlisle R, Chilvers C, Avery A ( 1997 ) . Are patients who present late with cancer registered with low referring practices? . British Journal of General Practice vol. 47 , ( 424 ) 731 - 732 .

Williams T, Jackson A, Turbitt D, Scrivener G, Lloyd D, Sturdy P, Pereira F, Hull S et al. ( 1997 ) . Effect of deprivation on general practitioners' referral rates . BMJ vol. 315 , ( 7112 ) 882 - 883 .

Davies SJC, Ghahramani P, Jackson PR, Hippisley-Cox J, Yeo WW, Ramsay LE ( 1997 ) . Panic disorder, anxiety and depression in resistant hypertension - a case–control study . Journal of Hypertension vol. 15 , ( 10 ) 1077 - 1082 .

Hippisley-Cox J ( 1997 ) . A pilot study of a randomized controlled trial of pragmatic eradication of Helicobactor pylori in primary care . British Journal of General Practice vol. 47 , ( 419 ) 375 - 377 .

Hippisley-Cox J, Hardy C, Pringle M, Fielding K, Carlisle R, Chilvers C ( 1997 ) . The effect of deprivation on variations in general practitioners' referral rates: a cross sectional study of computerised data on new medical and surgical outpatient referrals in Nottinghamshire . BMJ vol. 314 , ( 7092 ) 1458 - 1458 .

Smeeth L, Hippisley-Cox J, Paris JAG, Tiner R ( 1997 ) . Newly licensed drugs (multiple letters) [5] . British Medical Journal vol. 314 , ( 7080 ) 604 - 605 .

Smeeth L, Hippisley-Cox J, Paris JAG, Tiner R ( 1997 ) . Newly licensed drugs . BMJ vol. 314 , ( 7080 ) 604 - 604 .

Hippisley-Cox J ( 1997 ) . Newly licensed drugs. Randomised controlled trials are needed in primary care before new drugs are licensed . BMJ (Clinical research ed.) vol. 314 , ( 7080 ) 604 - 605 .

HippisleyCox J, Hardy C, Pringle M, Carlisle R, Fielding K, Chilvers C ( 1997 ) . Effect of deprivation on general practitioners' referral rates - reply . BRITISH MEDICAL JOURNAL vol. 315 , ( 7112 ) 884 - 884 .

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