Publications: PROF Graham Meintjes

Meintjes G, Maartens G ( 2026 ) . ART timing in people being investigated for tuberculosis . The Lancet HIV

Wieder C, Horswell S, Kelly G, Stek C, Moseki R, Rossi-Smith P, Ebbels TMD, Wilkinson RJ et al. ( 2026 ) . Novel genetic variants in tuberculosis-associated immune reconstitution inflammatory syndrome . American Journal of Respiratory and Critical Care Medicine

Kuhlin J, Stadler JAM, Grint DJ, Court R, Meintjes G, Mtwa N, Maartens G, Wasserman S ( 2026 ) . Treatment Adherence With an Oral 9-Month Regimen for Rifampicin-Resistant Tuberculosis in South Africa . Clinical Infectious Diseases

Ndjeka N, Perumal R, Romanowski K, Mathema H, Amusa LB, Campbell JR, Conradie F, Schaaf HS et al. ( 2026 ) . Treatment Outcomes and Drug-Related Adverse Events Across Four Short-Course RR-TB Regimens in South Africa: A Retrospective Analysis . International Journal of Infectious Diseases vol. 165 ,

Fieggen J, Meintjes G, Boulle A, Euvrard J ( 2026 ) . Characteristics of Individuals With Advanced HIV Disease and Risk Factors for Mortality in a Contemporary Cohort in South Africa . JAIDS Journal of Acquired Immune Deficiency Syndromes vol. 101 , ( 1 ) 30 - 40 .

Scheier TC, De Gouveia K, Engel ME, Hohlfeld AS-J, Cen A, Berhe A, Fan S, Li J et al. ( 2025 ) . One-year mortality among adults with advanced HIV in sub-Saharan Africa: a systematic review and meta-analysis . AIDS

Calderin JM, Resendiz-Galvan JE, Abdelgawad N, Davis A, Stek C, Wiesner L, Meintjes G, Wilkinson RJ et al. ( 2025 ) . Pharmacokinetics of Dexamethasone in Tuberculous Meningitis . Clinical Infectious Diseases

Moolla H, Meintjes G, Davies M-A, Kassanjee R, de Waal R, Johnson LF ( 2025 ) . Short-Term CD4+ Cell Count Declines During Antiretroviral Therapy Interruptions: A Focused Review . JAIDS Journal of Acquired Immune Deficiency Syndromes vol. 100 , ( 3 ) e11 - e13 .

Lee-Jones S, Rebe K, Marais S, Meintjes G, Parker A, van der Plas H ( 2025 ) . Thalidomide as an Adjunctive Therapy for HIV-Tuberculosis–Associated Immune Reconstitution Inflammatory Syndrome: A Case Series . Open Forum Infectious Diseases vol. 12 , ( 11 )

Choshi P, Pedretti S, Chimbetete T, Gangula R, Shey M, Stek C, Lai RPJ, Wilkinson R et al. ( 2025 ) . The association of class II HLA alleles with tuberculosis-associated immune reconstitution inflammatory syndrome . PLOS Pathogens vol. 21 , ( 9 )

Rossi-Smith P, Kim J, Skirlo K, Ferris T, Green JP, Stek C, Huse KK, Mortimer PM et al. ( 2025 ) . Taurine transport is a critical modulator of ionic fluxes during NLRP3 inflammasome activation . Cell Reports vol. 44 , ( 10 )

Ellis J, Groppelli E, Doyle R, Lawrence DS, Meya DB, Boulware DR, Mwandumba HC, Kanyama C et al. ( 2025 ) . Epstein–Barr virus and cytomegalovirus co-infections and mortality risk in patients with HIV-associated cryptococcal meningitis: a post-hoc analysis of a prospective nested cohort in the AMBITION-cm randomised controlled trial . The Lancet HIV vol. 12 , ( 10 ) e691 - e700 .

Phillips AN, Bansi-Matharu L, van Oosterhout JJ, Hyle E, van de Vijver D, Kouyos R, Hong SY, Chun H et al. ( 2025 ) . Evaluation of antiretroviral regimen switching options in adults with HIV with sustained viral load non-suppression on dolutegravir, lamivudine, and tenofovir in eastern, central, southern, and western Africa: a modelling study . The Lancet HIV vol. 12 , ( 8 ) e578 - e586 .

Mdlenyani L, Mohamed Z, Stadler JAM, Mtwa N, Meintjes G, Warren R, Saunders MJ, Kuhlin J et al. ( 2025 ) . Treatment outcomes of bedaquiline-resistant tuberculosis: a retrospective and matched cohort study . The Lancet Infectious Diseases vol. 25 , ( 10 ) 1149 - 1158 .

Mntonintshi M, Sossen B, Bookholane H, Lifson A, Africa L, Goliath R, Wearne N, Parrish A et al. ( 2025 ) . Urine-based assays for inpatients with HIV-associated tuberculosis in rural South Africa . Southern African Journal of HIV Medicine vol. 26 , ( 1 )

Vitoria M, Meintjes G, Ford N, Frigati L, Sugandhi N, Calmy A ( 2025 ) . Retiring the language of first-line and second-line ART . The Lancet HIV vol. 12 , ( 9 ) e608 - e610 .

Barr DA, Boloko L, Davies GD, Warner D, Schutz C, Meintjes G ( 2025 ) . CFU counting may underestimate TB bacilli number of blood, biasing limit of detection estimates in spiking experiments . The International Journal of Tuberculosis and Lung Disease vol. 29 , ( 6 ) 283 - 284 .

Stadler JAM, Kuhlin J, Molloy SF, Mtwa N, Hayes C, Stead D, Maartens G, Warren R et al. ( 2025 ) . Treatment Outcomes With an Oral Short Course Regimen for Rifampicin-resistant Tuberculosis in a High HIV Prevalence, Programmatic Setting in South Africa . Clinical Infectious Diseases vol. 81 , ( 4 ) e153 - e162 .

Boyles T, Sossen B, Omar SV, Meintjes G, Taljaard J ( 2025 ) . Equitable access to diagnostic resources means one Xpert-Ultra cartridge for all inpatients with HIV being investigated for tuberculosis . South African Medical Journal vol. 115 , ( 4 ) e3102 - e3102 .

Vermeulen M, Scarsi KK, Furl R, Sayles H, Anderson MJ, Valawalkar S, Kadam A, Cox SR et al. ( 2025 ) . Patient and provider preferences for long-acting TB preventive therapy . IJTLD OPEN vol. 2 , ( 5 ) 276 - 283 .

van Heerden JK, Zhao Y, Keene CM, Griesel R, Omar Z, Goliath R, Delaney K, van Zyl G et al. ( 2025 ) . Longer-term virologic outcomes on tenofovir-lamivudine-dolutegravir in second-line ART . Southern African Journal of HIV Medicine vol. 26 , ( 1 )

Abdelgawad N, Wasserman S, Gausi K, Davis A, Stek C, Wiesner L, Meintjes G, Wilkinson RJ et al. ( 2025 ) . Population Pharmacokinetics of Rifampicin in Plasma and Cerebrospinal Fluid in Adults With Tuberculosis Meningitis . Journal of Infectious Diseases vol. 232 , ( 2 ) e234 - e241 .

Boloko L, Vermeulen M, Sossen B, Bekiswa A, Namale PE, Centner C, Wilkinson RJ, Schutz C et al. ( 2025 ) . Blood and urine early treatment response biomarkers in HIV-associated disseminated tuberculosis . Southern African Journal of HIV Medicine vol. 26 , ( 1 )

Stead D, Wasserman S, Steenkamp E, Parrish A, Barr D, Meintjes G ( 2025 ) . Comparative Performance of Urine Lipoarabinomannan and Urine Xpert MTB/RIF Ultra for Diagnosing Tuberculosis in Adult Inpatients With HIV in East London, South Africa . Clinical Infectious Diseases vol. 81 , ( 4 ) e146 - e152 .

Scheier TC, Tufa TB, Feldt T, Hardy Y, Minga A, Moh R, Damasceno A, Chambal L et al. ( 2025 ) . Standard of care in advanced HIV disease: review of HIV treatment guidelines in sub-Saharan African countries—an extension study of eight countries . AIDS Research and Therapy vol. 22 , ( 1 )

Mave V, Paradkar M, Conradie F, Gupta A, Avihingsanon A, Meintjes G, Turkova A, Dooley KE et al. ( 2025 ) . Tuberculosis disease among people with HIV: therapeutic advances . The Lancet HIV vol. 12 , ( 5 ) e367 - e381 .

Goletti D, Matteelli A, Cliff JM, Meintjes G, Graham S, Esmail H, Shan Lee S ( 2025 ) . World TB Day 2025 Theme “Yes! We Can End TB: Commit, Invest, Deliver” can be made a reality through concerted global efforts to advance diagnosis, treatment and research of tuberculosis infection and disease . International Journal of Infectious Diseases vol. 155 ,

Sossen B, Kubjane M, Meintjes G ( 2025 ) . Tuberculosis and HIV coinfection: Progress and challenges towards reducing incidence and mortality . International Journal of Infectious Diseases vol. 155 ,

Zhao Y, Holtman M, Mudaly V, van Zyl G, Maartens G, Meintjes G ( 2025 ) . Brief Report: Resistance to Dolutegravir in Treatment-Experienced Patients in South Africa: A Retrospective Cohort Study . JAIDS Journal of Acquired Immune Deficiency Syndromes vol. 99 , ( 3 ) 283 - 287 .

Moyo M, Lawrence DS, Jafali J, Molloy SF, Kanyama C, Ndhlovu CE, Mosepele M, Meya DB et al. ( 2025 ) . Recent Antiretroviral Therapy Initiation Is Associated With Increased Mortality Risk in HIV–associated Cryptococcal Meningitis: An Analysis of Clinical Trial Data From Africa . Clinical Infectious Diseases vol. 81 , ( 1 ) 75 - 83 .

Goletti D, Meintjes G, Zumla A ( 2024 ) . Insights from the 2024 WHO Global Tuberculosis Report – More Comprehensive Action, Innovation, and Investments required for achieving WHO End TB goals . International Journal of Infectious Diseases vol. 150 ,

Syarif O, Oladele R, Gils T, Rajasingham R, Falconer J, Achii P, Tembo E, Tobaiwa DD et al. ( 2024 ) . Resolving the CD4-testing crisis to help end AIDS-related deaths . The Lancet Global Health vol. 13 , ( 1 ) e16 - e18 .

Walker NF, Schutz C, Ward A, Barr D, Opondo C, Shey M, Elkington PT, Wilkinson KA et al. ( 2024 ) . Elevated Plasma Matrix Metalloproteinases Are Associated With Mycobacterium tuberculosis Bloodstream Infection and Mortality in Human Immunodeficiency Virus–Associated Tuberculosis . Journal of Infectious Diseases vol. 231 , ( 1 ) 109 - 114 .

Meintjes G ( 2024 ) . HIV-Associated Tuberculosis . The New England Journal of Medicine vol. 391 , ( 4 ) 343 - 355 .

Hermans SM, Akkerman OW, Grobusch MP ( 2024 ) . Post-tuberculosis treatment paradoxical reactions . Infection vol. 52 , ( 5 ) 2083 - 2095 .

Davis AG, Wasserman S, Stek C, Maxebengula M, Jason Liang C, Stegmann S, Koekemoer S, Jackson A et al. ( 2022 ) . A Phase 2A Trial of the Safety and Tolerability of Increased Dose Rifampicin and Adjunctive Linezolid, With or Without Aspirin, for Human Immunodeficiency Virus–Associated Tuberculous Meningitis: The LASER-TBM Trial . Clinical Infectious Diseases vol. 76 , ( 8 ) 1412 - 1422 .

Davis AG, Wasserman S, Maxebengula M, Stek C, Bremer M, Daroowala R, Aziz S, Goliath R et al. ( 2021 ) . Study protocol for a phase 2A trial of the safety and tolerability of increased dose rifampicin and adjunctive linezolid, with or without aspirin, for HIV-associated tuberculous meningitis [LASER-TBM] . Wellcome Open Research vol. 6 ,

Mendelson M, Booyens L, Boutall A, Cairncross L, Calligaro G, Dave JA, Dlamini S, Dyer S et al. ( 2020 ) . The mechanics of setting up a COVID-19 response: Experiences of the COVID-19 epidemic from Groote Schuur Hospital, Cape Town, South Africa . South African Medical Journal vol. 110 , ( 10 ) 968 - 972 .

Mendelson M, Boloko L, Boutall A, Cairncross L, Calligaro G, Coccia C, Dave JA, de Villiers M et al. ( 2020 ) . Clinical management of COVID-19: Experiences of the COVID-19 epidemic from Groote Schuur Hospital, Cape Town, South Africa . South African Medical Journal vol. 110 , ( 10 ) 973 - 981 .

Barr DA, Lewis JM, Feasey N, Schutz C, Kerkhoff AD, Jacob ST, Andrews B, Kelly P et al. ( 2020 ) . Mycobacterium tuberculosis bloodstream infection prevalence, diagnosis, and mortality risk in seriously ill adults with HIV: a systematic review and meta-analysis of individual patient data . The Lancet Infectious Diseases vol. 20 , ( 6 ) 742 - 752 .

Barr DA, Lewis JM, Feasey N, Schutz C, Kerkhoff AD, Jacob ST, Andrews B, Kelly P et al. ( 2019 ) . Mycobacterium Tuberculosis Blood Stream Infection Prevalence, Diagnosis, and Mortality Hazard in HIV-Positive Adults: A Systematic Review and Meta-Analysis of Individual Patient Data .

Conesa-Botella A, Meintjes G, Coussens AK, van der Plas H, Goliath R, Schutz C, Moreno-Reyes R, Mehta M et al. ( 2012 ) . Corticosteroid Therapy, Vitamin D Status, and Inflammatory Cytokine Profile in the HIV-Tuberculosis Immune Reconstitution Inflammatory Syndrome . Clinical Infectious Diseases vol. 55 , ( 7 ) 1004 - 1011 .

Sossen B, Schutz C, Boloko L, Broger T, Ward A, Bekiswa A, Balfour A, Shey M et al. . A measurement model to quantify systemic bacilli load in severe HIV-associated tuberculosis .

Samuels THA, Molloy SF, Lawrence DS, Loyse A, Kanyama C, Heyderman RS, Lai WS, Mfinanga S et al. . Personalised risk prediction tools for cryptococcal meningitis mortality to guide treatment stratification; a pooled analysis of two randomised-controlled trials .

Calderin JM, Resendiz-Galvan JE, Abdelgawad N, Davis A, Stek C, Wiesner L, Meintjes G, Wilkinson RJ et al. . Pharmacokinetics of dexamethasone in tuberculosis meningitis .

Mdlenyani L, Mohamed Z, Stadler JA, Mtwa N, Meintjes G, Warren R, Kuhlin J, Wasserman S . Treatment outcomes of bedaquiline-resistant tuberculosis: a retrospective and matched cohort study .

Balfour A, Masina N, Queiroz ATL, Andrade BB, Fukutani ER, Bekiswa A, Lewinsohn D, Lewinsohn D et al. . Two distinct cytokine response clusters identified in healthcare workers with apparent resistance to infection with Mycobacterium tuberculosis despite sustained occupational exposure .