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  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: Dr Simon Haas

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Lutz R, Poos AM, Solé-Boldo L, John L, Wagner J, Prokoph N, Baertsch MA, Vonficht D et al. ( 2025 ) . Bone marrow breakout lesions act as key sites for tumor-immune cell diversification in multiple myeloma . Science Immunology vol. 10 , ( 104 )
Lutz R, Grünschläger F, Simon M, Awwad MHS, Bauer M, Yousefian S, Beumer N, Jopp-Saile L et al. ( 2024 ) . Multiple myeloma long-term survivors exhibit sustained immune alterations decades after first-line therapy . Nature Communications vol. 15 , ( 1 )
Yanai I, Haas S, Lippert C, Kretzmer H ( 2024 ) . Cellular atlases are unlocking the mysteries of the human body . Nature vol. 635 , ( 8039 ) 553 - 555 .
Derigs P, Schubert M-L, Dreger P, Schmitt A, Yousefian S, Haas S, Röthemeier C, Neuber B et al. ( 2024 ) . Third-generation anti-CD19 CAR T cells for relapsed/refractory chronic lymphocytic leukemia: a phase 1/2 study . Leukemia vol. 38 , ( 11 ) 2419 - 2428 .
Carrasco-Zanini J, Pietzner M, Davitte J, Surendran P, Croteau-Chonka DC, Robins C, Torralbo A, Tomlinson C et al. ( 2024 ) . Proteomic signatures improve risk prediction for common and rare diseases . Nature Medicine vol. 30 , ( 9 ) 2489 - 2498 .
Ramberger E, Sapozhnikova V, Ng YLD, Dolnik A, Ziehm M, Popp O, Sträng E, Kull M et al. ( 2024 ) . The proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunities . Nature Cancer vol. 5 , ( 8 ) 1267 - 1284 .
Baumgartner F, Bamopoulos SA, Faletti L, Hsiao H-J, Holz M, Gonzalez-Menendez I, Solé-Boldo L, Horne A et al. ( 2024 ) . Activation of gp130 signaling in T cells drives TH17-mediated multi-organ autoimmunity . Science Signaling vol. 17 , ( 824 )
Winkler I, Tolkachov A, Lammers F, Lacour P, Daugelaite K, Schneider N, Koch M-L, Panten J et al. ( 2024 ) . The cycling and aging mouse female reproductive tract at single-cell resolution . Cell vol. 187 , ( 4 ) 981 - 998.e25 .
Bouman BJ, Demerdash Y, Sood S, Grünschläger F, Pilz F, Itani AR, Kuck A, Marot-Lassauzaie V et al. ( 2023 ) . Single-cell time series analysis reveals the dynamics of HSPC response to inflammation . Life Science Alliance vol. 7 , ( 3 )
Funk MC, Gleixner JG, Heigwer F, Vonficht D, Valentini E, Aydin Z, Tonin E, Del Prete S et al. ( 2023 ) . Aged intestinal stem cells propagate cell-intrinsic sources of inflammaging in mice . Developmental Cell vol. 58 , ( 24 ) 2914 - 2929.e7 .
Solé-Boldo L, Haas S ( 2023 ) . Systematic perturbation of chromatin factors identifies regulatory networks during healthy and malignant hematopoiesis . Nature Genetics vol. 55 , ( 9 ) 1430 - 1431 .
John L, Poos AM, Brobeil A, Schinke C, Huhn S, Prokoph N, Lutz R, Wagner B et al. ( 2023 ) . Resolving the spatial architecture of myeloma and its microenvironment at the single-cell level . Nature Communications vol. 14 , ( 1 )
Eifert T, Hsu C-J, Becker AL, Graessle S, Horne A, Bemmann F, Zhang Q, Heuser M et al. ( 2023 ) . Cell fate determinant Llgl1 is required for propagation of acute myeloid leukemia . Leukemia vol. 37 , ( 10 ) 2027 - 2035 .
Schubert M-L, Schmitt A, Hückelhoven-Krauss A, Neuber B, Kunz A, Waldhoff P, Vonficht D, Yousefian S et al. ( 2023 ) . Treatment of adult ALL patients with third-generation CD19-directed CAR T cells: results of a pivotal trial . Journal of Hematology & Oncology vol. 16 , ( 1 )
Saini M, Schmidleitner L, Moreno HD, Donato E, Falcone M, Bartsch JM, Klein C, Vogel V et al. ( 2023 ) . Resistance to mesenchymal reprogramming sustains clonal propagation in metastatic breast cancer . Cell Reports vol. 42 , ( 6 )
Beneyto-Calabuig S, Merbach AK, Kniffka J-A, Antes M, Szu-Tu C, Rohde C, Waclawiczek A, Stelmach P et al. ( 2023 ) . Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia . Cell Stem Cell vol. 30 , ( 5 ) 706 - 721.e8 .
Kurtova AV, Heinlein M, Haas S, Velten L, Dijkgraaf GJP, Storm EE, Kljavin NM, Boumahdi S et al. ( 2023 ) . Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis . Blood Advances vol. 7 , ( 4 ) 491 - 507 .
Obermayer B, Keilholz L, Conrad T, Frentsch M, Blau I-W, Vuong L, Lesch S, Movasshagi K et al. ( 2023 ) . Single-cell clonal tracking of persistent T-cells in allogeneic hematopoietic stem cell transplantation . Frontiers in Immunology vol. 14 ,
Demel UM, Wirth M, Yousefian S, Zhang L, Isaakidis K, Dönig J, Böger M, Singh N et al. ( 2022 ) . Small-molecule SUMO inhibition for biomarker-informed B-cell lymphoma therapy . Haematologica vol. 108 , ( 2 ) 555 - 567 .
Raffel S, Velten L, Haas S ( 2022 ) . Cellular hierarchies predict drug response in acute myeloid leukemia . Cancer Cell vol. 40 , ( 9 ) 917 - 919 .
Bogeska R, Mikecin A-M, Kaschutnig P, Fawaz M, Büchler-Schäff M, Le D, Ganuza M, Vollmer A et al. ( 2022 ) . Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging . Cell Stem Cell vol. 29 , ( 8 ) 1273 - 1284.e8 .
Demel UM, Lutz R, Sujer S, Demerdash Y, Sood S, Grünschläger F, Kuck A, Werner P et al. ( 2022 ) . A complex proinflammatory cascade mediates the activation of HSCs upon LPS exposure in vivo . Blood Advances vol. 6 , ( 11 ) 3513 - 3528 .
Demel UM, Böger M, Yousefian S, Grunert C, Zhang L, Hotz PW, Gottschlich A, Köse H et al. ( 2022 ) . Activated SUMOylation restricts MHC class I antigen presentation to confer immune evasion in cancer . Journal of Clinical Investigation vol. 132 , ( 9 )
Hernández-Malmierca P, Vonficht D, Schnell A, Uckelmann HJ, Bollhagen A, Mahmoud MAA, Landua S-L, van der Salm E et al. ( 2022 ) . Antigen presentation safeguards the integrity of the hematopoietic stem cell pool . Cell Stem Cell vol. 29 , ( 5 ) 760 - 775.e10 .
Trumpp A, Haas S ( 2022 ) . Cancer stem cells: The adventurous journey from hematopoietic to leukemic stem cells . Cell vol. 185 , ( 8 ) 1266 - 1270 .
Maschmeyer P, Haas S ( 2022 ) . ATACing single cells with phages . Molecular Cell vol. 82 , ( 2 ) 234 - 236 .
Triana S, Vonficht D, Jopp-Saile L, Raffel S, Lutz R, Leonce D, Antes M, Hernández-Malmierca P et al. ( 2021 ) . Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states . Nature Immunology vol. 22 , ( 12 ) 1577 - 1589 .
Young K, Eudy E, Bell R, Loberg MA, Stearns T, Sharma D, Velten L, Haas S et al. ( 2021 ) . Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging . Cell Stem Cell vol. 28 , ( 8 ) 1473 - 1482.e7 .
Velten L, Story BA, Hernández-Malmierca P, Raffel S, Leonce DR, Milbank J, Paulsen M, Demir A et al. ( 2021 ) . Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics . Nature Communications vol. 12 , ( 1 )
Lutsik P, Baude A, Mancarella D, Öz S, Kühn A, Toth R, Hey J, Toprak UH et al. ( 2020 ) . Globally altered epigenetic landscape and delayed osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of bone . Nature Communications vol. 11 , ( 1 )
Carrelha J, Lin DS, Rodriguez-Fraticelli AE, Luis TC, Wilkinson AC, Cabezas-Wallscheid N, Tremblay CS, Haas S ( 2020 ) . Single-cell lineage tracing approaches in hematology research: technical considerations . Experimental Hematology vol. 89 , 26 - 36 .
Loughran SJ, Haas S, Wilkinson AC, Klein AM, Brand M ( 2020 ) . Lineage commitment of hematopoietic stem cells and progenitors: insights from recent single cell and lineage tracing technologies . Experimental Hematology vol. 88 , 1 - 6 .
Al-Sabah J, Baccin C, Haas S ( 2020 ) . Single-cell and spatial transcriptomics approaches of the bone marrow microenvironment . Current Opinion in Oncology vol. 32 , ( 2 ) 146 - 153 .
Baccin C, Al-Sabah J, Velten L, Helbling PM, Grünschläger F, Hernández-Malmierca P, Nombela-Arrieta C, Steinmetz LM et al. ( 2019 ) . Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization . Nature Cell Biology vol. 22 , ( 1 ) 38 - 48 .
Haas S, Trumpp A, Milsom MD ( 2018 ) . Causes and Consequences of Hematopoietic Stem Cell Heterogeneity . Cell Stem Cell vol. 22 , ( 5 ) 627 - 638 .
Haas S, Trumpp A ( 2018 ) . An Intrinsic Interferon Program Protects Stem Cells from Viral Infection . Developmental Cell vol. 44 , ( 3 ) 279 - 280 .
Gundry MC, Dever DP, Yudovich D, Bauer DE, Haas S, Wilkinson AC, Singbrant S ( 2017 ) . Technical considerations for the use of CRISPR/Cas9 in hematology research . Experimental Hematology vol. 54 , 4 - 11 .
Brocks D, Schmidt CR, Daskalakis M, Jang HS, Shah NM, Li D, Li J, Zhang B et al. ( 2017 ) . DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats . Nature Genetics vol. 49 , ( 7 ) 1052 - 1060 .
Hirche C, Frenz T, Haas SF, Döring M, Borst K, Tegtmeyer P-K, Brizic I, Jordan S et al. ( 2017 ) . Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo . Cell Reports vol. 19 , ( 11 ) 2345 - 2356 .
Velten L, Haas SF, Raffel S, Blaszkiewicz S, Islam S, Hennig BP, Hirche C, Lutz C et al. ( 2017 ) . Human haematopoietic stem cell lineage commitment is a continuous process . Nature Cell Biology vol. 19 , ( 4 ) 271 - 281 .
Prendergast ÁM, Kuck A, van Essen M, Haas S, Blaszkiewicz S, Essers MAG ( 2016 ) . IFNα-mediated remodeling of endothelial cells in the bone marrow niche . Haematologica vol. 102 , ( 3 ) 445 - 453 .
Uckelmann H, Blaszkiewicz S, Nicolae C, Haas S, Schnell A, Wurzer S, Wagener R, Aszodi A et al. ( 2016 ) . Extracellular matrix protein Matrilin-4 regulates stress-induced HSC proliferation via CXCR4 . Journal of Experimental Medicine vol. 213 , ( 10 ) 1961 - 1971 .
Scognamiglio R, Cabezas-Wallscheid N, Thier MC, Altamura S, Reyes A, Prendergast ÁM, Baumgärtner D, Carnevalli LS et al. ( 2016 ) . Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause . Cell vol. 164 , ( 4 ) 668 - 680 .
Paul F, Arkin Y, Giladi A, Jaitin DA, Kenigsberg E, Keren-Shaul H, Winter D, Lara-Astiaso D et al. ( 2015 ) . Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors . Cell vol. 163 , ( 7 ) 1663 - 1677 .
Haas S, Hansson J, Klimmeck D, Loeffler D, Velten L, Uckelmann H, Wurzer S, Prendergast ÁM et al. ( 2015 ) . Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors . Cell Stem Cell vol. 17 , ( 4 ) 422 - 434 .
Lipka DB, Wang Q, Cabezas-Wallscheid N, Klimmeck D, Weichenhan D, Herrmann C, Lier A, Brocks D et al. ( 2014 ) . Identification of DNA methylation changes at cis-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfite sequencing . Cell Cycle vol. 13 , ( 22 ) 3476 - 3487 .
Cabezas-Wallscheid N, Klimmeck D, Hansson J, Lipka DB, Reyes A, Wang Q, Weichenhan D, Lier A et al. ( 2014 ) . Identification of Regulatory Networks in HSCs and Their Immediate Progeny via Integrated Proteome, Transcriptome, and DNA Methylome Analysis . Cell Stem Cell vol. 15 , ( 4 ) 507 - 522 .
Klattenhoff CA, Scheuermann JC, Surface LE, Bradley RK, Fields PA, Steinhauser ML, Ding H, Butty VL et al. ( 2013 ) . Braveheart, a Long Noncoding RNA Required for Cardiovascular Lineage Commitment . Cell vol. 152 , ( 3 ) 570 - 583 .
Ketzer P, Haas SF, Engelhardt S, Hartig JS, Nettelbeck DM ( 2012 ) . Synthetic riboswitches for external regulation of genes transferred by replication-deficient and oncolytic adenoviruses . Nucleic Acids Research vol. 40 , ( 21 ) e167 - e167 .
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