Publications: Dr Michael Spencer Chapman

Kamizela AE, Leongamornlert D, Williams N, Wang X, Nyamondo K, Dawson K, Spencer Chapman M, Guo J et al. ( 2025 ) . Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia . Nature vol. 640 , ( 8060 ) 982 - 990 .

Spencer Chapman M, Mitchell E, Yoshida K, Williams N, Fabre MA, Ranzoni AM, Robinson PS, Kregar LD et al. ( 2025 ) . Prolonged persistence of mutagenic DNA lesions in somatic cells . Nature vol. 638 , ( 8051 ) 729 - 738 .

Spencer Chapman M, Wilk CM, Boettcher S, Mitchell E, Dawson K, Williams N, Müller J, Kovtonyuk L et al. ( 2024 ) . Clonal dynamics after allogeneic haematopoietic cell transplantation . Nature vol. 635 , ( 8040 ) 926 - 934 .

Bernstein N, Spencer Chapman M, Nyamondo K, Chen Z, Williams N, Mitchell E, Campbell PJ, Cohen RL et al. ( 2024 ) . Analysis of somatic mutations in whole blood from 200,618 individuals identifies pervasive positive selection and novel drivers of clonal hematopoiesis . Nature Genetics vol. 56 , ( 6 ) 1147 - 1155 .

Coorens THH, Spencer Chapman M, Williams N, Martincorena I, Stratton MR, Nangalia J, Campbell PJ ( 2024 ) . Reconstructing phylogenetic trees from genome-wide somatic mutations in clonal samples . Nature Protocols vol. 19 , ( 6 ) 1866 - 1886 .

Spencer Chapman M, Cull AH, Ciuculescu MF, Esrick EB, Mitchell E, Jung H, O’Neill L, Roberts K et al. ( 2023 ) . Clonal selection of hematopoietic stem cells after gene therapy for sickle cell disease . Nature Medicine vol. 29 , ( 12 ) 3175 - 3183 .

Pascall DJ, Vink E, Blacow R, Bulteel N, Campbell A, Campbell R, Clifford S, Davis C et al. ( 2023 ) . The SARS-CoV-2 Alpha variant was associated with increased clinical severity of COVID-19 in Scotland: A genomics-based retrospective cohort analysis . PLOS ONE vol. 18 , ( 4 )

Cotton S, McHugh MP, Dewar R, Haas JG, Templeton K, Consortium TCGU, Robson SC, Connor TR et al. ( 2023 ) . Investigation of hospital discharge cases and SARS-CoV-2 introduction into Lothian care homes . Journal of Hospital Infection vol. 135 , 28 - 36 .

Willett BJ, Grove J, MacLean OA, Wilkie C, De Lorenzo G, Furnon W, Cantoni D, Scott S et al. ( 2022 ) . Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway . Nature Microbiology vol. 7 , ( 10 ) 1709 - 1709 .

Wilkinson SAJ, Richter A, Casey A, Osman H, Mirza JD, Stockton J, Quick J, Ratcliffe L et al. ( 2022 ) . Recurrent SARS-CoV-2 mutations in immunodeficient patients . Virus Evolution vol. 8 , ( 2 )

Baker S, Dougan G, Hess C, Kingston N, Lehner PJ, Lyons PA, Matheson NJ, Owehand WH et al. ( 2022 ) . Author Correction: SARS-CoV-2 evolution during treatment of chronic infection . Nature vol. 608 , ( 7922 ) e23 - e23 .

Baker S, Dougan G, Hess C, Kingston N, Lehner PJ, Lyons PA, Matheson NJ, Owehand WH et al. ( 2022 ) . Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies . Nature vol. 608 , ( 7922 ) e24 - e24 .

Smallman-Raynor MR, Cliff AD, Consortium TCGU ( 2022 ) . Spatial growth rate of emerging SARS-CoV-2 lineages in England, September 2020–December 2021 . Epidemiology and Infection vol. 150 ,

Willett BJ, Grove J, MacLean OA, Wilkie C, De Lorenzo G, Furnon W, Cantoni D, Scott S et al. ( 2022 ) . SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway . Nature Microbiology vol. 7 , ( 8 ) 1161 - 1179 .

Robson SC, Connor TR, Loman NJ, Golubchik T, Martinez Nunez RT, Bonsall D, Rambaut A, Snell LB et al. ( 2022 ) . Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England . Nature vol. 606 , ( 7915 ) e18 - e18 .

Mitchell E, Spencer Chapman M, Williams N, Dawson KJ, Mende N, Calderbank EF, Jung H, Mitchell T et al. ( 2022 ) . Clonal dynamics of haematopoiesis across the human lifespan . Nature vol. 606 , ( 7913 ) 343 - 350 .

Fabre MA, de Almeida JG, Fiorillo E, Mitchell E, Damaskou A, Rak J, Orrù V, Marongiu M et al. ( 2022 ) . The longitudinal dynamics and natural history of clonal haematopoiesis . Nature vol. 606 , ( 7913 ) 335 - 342 .

Wright DW, Harvey WT, Hughes J, Cox M, Peacock TP, Colquhoun R, Jackson B, Orton R et al. ( 2022 ) . Tracking SARS-CoV-2 mutations and variants through the COG-UK-Mutation Explorer . Virus Evolution vol. 8 , ( 1 )

de Silva TI, Liu G, Lindsey BB, Dong D, Moore SC, Hsu NS, Shah D, Wellington D et al. ( 2021 ) . The impact of viral mutations on recognition by SARS-CoV-2 specific T cells . iScience vol. 24 , ( 11 )

Robson SC, Connor TR, Loman NJ, Golubchik T, Martinez Nunez RT, Bonsall D, Rambaut A, Snell LB et al. ( 2021 ) . Genomic reconstruction of the SARS-CoV-2 epidemic in England . Nature vol. 600 , ( 7889 ) 506 - 511 .

Spencer Chapman M, Nangalia J ( 2021 ) . Caught in the antiviral crossfire: Ganciclovir-associated mutagenesis in HSC transplant recipients . Cell Stem Cell vol. 28 , ( 10 ) 1683 - 1685 .

Twohig KA, Nyberg T, Zaidi A, Thelwall S, Sinnathamby MA, Aliabadi S, Seaman SR, Harris RJ et al. ( 2021 ) . Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study . The Lancet Infectious Diseases vol. 22 , ( 1 ) 35 - 42 .

Coorens THH, Moore L, Robinson PS, Sanghvi R, Christopher J, Hewinson J, Przybilla MJ, Lawson ARJ et al. ( 2021 ) . Extensive phylogenies of human development inferred from somatic mutations . Nature vol. 597 , ( 7876 ) 387 - 392 .

Jackson B, Boni MF, Bull MJ, Colleran A, Colquhoun RM, Darby AC, Haldenby S, Hill V et al. ( 2021 ) . Generation and transmission of interlineage recombinants in the SARS-CoV-2 pandemic . Cell vol. 184 , ( 20 ) 5179 - 5188.e8 .

Tonkin-Hill G, Martincorena I, Amato R, Lawson AR, Gerstrung M, Johnston I, Jackson DK, Park N et al. ( 2021 ) . Patterns of within-host genetic diversity in SARS-CoV-2 . eLife vol. 10 ,

Meng B, Kemp SA, Papa G, Datir R, Ferreira IATM, Marelli S, Harvey WT, Lytras S et al. ( 2021 ) . Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7 . Cell Reports vol. 35 , ( 13 )

Spencer Chapman M, Ranzoni AM, Myers B, Williams N, Coorens THH, Mitchell E, Butler T, Dawson KJ et al. ( 2021 ) . Lineage tracing of human development through somatic mutations . Nature vol. 595 , ( 7865 ) 85 - 90 .

Abascal F, Harvey LMR, Mitchell E, Lawson ARJ, Lensing SV, Ellis P, Russell AJC, Alcantara RE et al. ( 2021 ) . Somatic mutation landscapes at single-molecule resolution . Nature vol. 593 , ( 7859 ) 405 - 410 .

Graham MS, Sudre CH, May A, Antonelli M, Murray B, Varsavsky T, Kläser K, Canas LS et al. ( 2021 ) . Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study . The Lancet Public Health vol. 6 , ( 5 ) e335 - e345 .

Baker S, Dougan G, Hess C, Kingston N, Lehner PJ, Lyons PA, Matheson NJ, Owehand WH et al. ( 2021 ) . Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies . Nature vol. 593 , ( 7857 ) 136 - 141 .

Hamilton WL, Tonkin-Hill G, Smith ER, Aggarwal D, Houldcroft CJ, Warne B, Meredith LW, Hosmillo M et al. ( 2021 ) . Genomic epidemiology of COVID-19 in care homes in the East of England . eLife vol. 10 ,

Baker S, Dougan G, Hess C, Kingston N, Lehner PJ, Lyons PA, Matheson NJ, Owehand WH et al. ( 2021 ) . SARS-CoV-2 evolution during treatment of chronic infection . Nature vol. 592 , ( 7853 ) 277 - 282 .

Thomson EC, Rosen LE, Shepherd JG, Spreafico R, da Silva Filipe A, Wojcechowskyj JA, Davis C, Piccoli L et al. ( 2021 ) . Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity . Cell vol. 184 , ( 5 ) 1171 - 1187.e20 .

Volz E, Hill V, McCrone JT, Price A, Jorgensen D, O’Toole Á, Southgate J, Johnson R et al. ( 2020 ) . Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity . Cell vol. 184 , ( 1 ) 64 - 75.e11 .

Spencer Chapman M, May PC, Olavarria E, Nadal Melsio E ( 2020 ) . Three distinct hematological malignancies from a single germ cell tumor: a case report . Journal of Medical Case Reports vol. 14 , ( 1 )

Chapman MS, Kiritkumar K, Lund K, Bain BJ ( 2018 ) . An unusual hemoglobinopathy: compound heterozygosity for hemoglobins C and E . American Journal of Hematology vol. 94 , ( 1 ) 144 - 144 .

Spencer‐Chapman M, Luqmani A, Layton DM, Bain BJ ( 2018 ) . Unusual inclusions in hemoglobin H disease post‐splenectomy . American Journal of Hematology vol. 93 , ( 7 ) 963 - 964 .

Chapman MS, Araf S, Smith M ( 2015 ) . Clinical and laboratory characteristics of acute myeloid leukaemia (AML) at relapse and the risk of acute incapacitation . Journal of Clinical Pathology vol. 69 , ( 3 )

Spencer-Chapman M, Harber M ( 2012 ) . Massive urinary tract haemorrhage following bladder decompression by urethral catheterisation . BJUI

Stephens PJ, Tarpey PS, Davies H, Van Loo P, Greenman C, Wedge DC, Nik-Zainal S, Martin S et al. ( 2012 ) . The landscape of cancer genes and mutational processes in breast cancer . Nature vol. 486 , ( 7403 ) 400 - 404 .