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Research
  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: DR Mike Spencer Chapman

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( 2025 ) . Clonal architecture and dynamics of somatic evolution in aplastic anemia and paroxysmal nocturnal hemoglobinuria . Blood . vol. 146 ,
Uryu H, Saeki K, Haeno H, Kapadia CD, Furudate K, Nangalia J, Spencer Chapman M, Zhang L et al. ( 2025 ) . Author Correction: Clonal evolution of hematopoietic stem cells after autologous stem cell transplantation . Nature Genetics vol. 57 , ( 9 ) 2339 - 2339 .
Mitchell E, Pham MH, Clay A, Sanghvi R, Williams N, Pietsch S, Hsu JI, Øbro NF et al. ( 2025 ) . Author Correction: The long-term effects of chemotherapy on normal blood cells . Nature Genetics vol. 57 , ( 8 ) 2075 - 2075 .
Uryu H, Saeki K, Haeno H, Kapadia CD, Furudate K, Nangalia J, Spencer Chapman M, Zhang L et al. ( 2025 ) . Clonal evolution of hematopoietic stem cells after autologous stem cell transplantation . Nature Genetics vol. 57 , ( 7 ) 1695 - 1707 .
Mitchell E, Pham MH, Clay A, Sanghvi R, Williams N, Pietsch S, Hsu JI, Øbro NF et al. ( 2025 ) . The long-term effects of chemotherapy on normal blood cells . Nature Genetics vol. 57 , ( 7 ) 1684 - 1694 .
Kregar LD, Williams N, Lee J, Spencer-Chapman M, Nikolaienko O, Mitchell E, Gansmo LB, Lønning PE et al. ( 2025 ) . Abstract LB308: Rewiring of methylation during embryogenesis can seed cancer decades later . Cancer Research vol. 85 , ( 8_Supplement_2 ) lb308 - lb308 .
Kamizela AE, Leongamornlert D, Williams N, Wang X, Nyamondo K, Dawson K, Guo J, Lee J et al. ( 2025 ) . Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia . Nature vol. 640 , ( 8060 ) 982 - 990 .
Spencer Chapman M, Mitchell E, Yoshida K, Williams N, Fabre MA, Ranzoni AM, Robinson PS, Kregar LD et al. ( 2025 ) . Prolonged persistence of mutagenic DNA lesions in somatic cells . Nature vol. 638 , ( 8051 ) 729 - 738 .
Spencer Chapman M, Wilk CM, Boettcher S, Mitchell E, Dawson K, Williams N, Müller J, Kovtonyuk L et al. ( 2024 ) . Clonal dynamics after allogeneic haematopoietic cell transplantation . Nature vol. 635 , ( 8040 ) 926 - 934 .
Bernstein N, Spencer Chapman M, Nyamondo K, Chen Z, Williams N, Cohen RL ( 2024 ) . Analysis of somatic mutations in whole blood from 200,618 individuals identifies pervasive positive selection and novel drivers of clonal hematopoiesis . Nature Genetics vol. 56 , ( 6 ) 1147 - 1155 .
Coorens THH, Spencer Chapman M, Williams N, Martincorena I, Stratton MR ( 2024 ) . Reconstructing phylogenetic trees from genome-wide somatic mutations in clonal samples . Nature Protocols vol. 19 , ( 6 ) 1866 - 1886 .
Spencer Chapman M, Cull AH, Ciuculescu MF, Esrick EB, Mitchell E, Jung H, O’Neill L, Roberts K et al. ( 2023 ) . Clonal selection of hematopoietic stem cells after gene therapy for sickle cell disease . Nature Medicine vol. 29 , ( 12 ) 3175 - 3183 .
Mitchell E, Spencer Chapman M, Williams N, Dawson KJ, Mende N, Calderbank EF, Jung H, Coorens THH et al. ( 2022 ) . Clonal dynamics of haematopoiesis across the human lifespan . Nature vol. 606 , ( 7913 ) 343 - 350 .
Fabre MA, de Almeida JG, Fiorillo E, Mitchell E, Damaskou A, Rak J, Orrù V, Marongiu M et al. ( 2022 ) . The longitudinal dynamics and natural history of clonal haematopoiesis . Nature vol. 606 , ( 7913 ) 335 - 342 .
Spencer Chapman M ( 2021 ) . Caught in the antiviral crossfire: Ganciclovir-associated mutagenesis in HSC transplant recipients . Cell Stem Cell vol. 28 , ( 10 ) 1683 - 1685 .
Coorens THH, Moore L, Robinson PS, Sanghvi R, Christopher J, Hewinson J, Przybilla MJ, Spencer Chapman M et al. ( 2021 ) . Extensive phylogenies of human development inferred from somatic mutations . Nature vol. 597 , ( 7876 ) 387 - 392 .
Spencer Chapman M, Ranzoni AM, Myers B, Williams N, Coorens THH, Mitchell E, Butler T, Dawson KJ et al. ( 2021 ) . Lineage tracing of human development through somatic mutations . Nature vol. 595 , ( 7865 ) 85 - 90 .
Abascal F, Harvey LMR, Mitchell E, Lawson ARJ, Lensing SV, Ellis P, Russell AJC, Alcantara RE et al. ( 2021 ) . Somatic mutation landscapes at single-molecule resolution . Nature vol. 593 , ( 7859 ) 405 - 410 .
Hamilton WL, Tonkin-Hill G, Smith ER, Aggarwal D, Houldcroft CJ, Warne B, Meredith LW, Hosmillo M et al. ( 2021 ) . Genomic epidemiology of COVID-19 in care homes in the East of England . eLife vol. 10 ,
Spencer Chapman M, May PC, Olavarria E ( 2020 ) . Three distinct hematological malignancies from a single germ cell tumor: a case report . Journal of Medical Case Reports vol. 14 , ( 1 )
Chapman MS, Kiritkumar K ( 2018 ) . An unusual hemoglobinopathy: compound heterozygosity for hemoglobins C and E . American Journal of Hematology vol. 94 , ( 1 ) 144 - 144 .
Spencer‐Chapman M, Luqmani A, Layton DM ( 2018 ) . Unusual inclusions in hemoglobin H disease post‐splenectomy . American Journal of Hematology vol. 93 , ( 7 ) 963 - 964 .
Chapman MS, Araf S ( 2015 ) . Clinical and laboratory characteristics of acute myeloid leukaemia (AML) at relapse and the risk of acute incapacitation . Journal of Clinical Pathology vol. 69 , ( 3 )
Spencer M, Greville‐Heygate F, Singer R, Rees J, MacDonagh R ( 2015 ) . Health Improvement Project Zanzibar: a new model of healthcare delivery . Trends in Urology & Men's Health vol. 6 , ( 5 ) 35 - 39 .
Spencer-Chapman M, Harber M ( 2012 ) . Massive urinary tract haemorrhage following bladder decompression by urethral catheterisation . BJUI
Stephens PJ, Tarpey PS, Davies H, Van Loo P, Greenman C, Wedge DC, Nik-Zainal S, Martin S et al. ( 2012 ) . The landscape of cancer genes and mutational processes in breast cancer . Nature vol. 486 , ( 7403 ) 400 - 404 .
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