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Research

Publications: DR Cara Croft

( 2024 ) . Reactive astrocytes secrete the chaperone HSPB1 to mediate neuroprotection . Science Advances vol. 10 , ( 12 ) Article eadk9884 ,
( 2023 ) . P2X7R influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytes . Brain, Behavior, and Immunity vol. 114 , 414 - 429 .
( 2022 ) . Optical pulse labeling studies reveal exogenous seeding slows α-synuclein clearance . npj Parkinson's Disease vol. 8 , ( 1 ) Article 173 ,
( 2022 ) . Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy . Molecular Neurodegeneration vol. 17 , ( 1 ) Article 80 ,
( 2022 ) . Pathogenic tau recruits wild-type tau into brain inclusions and induces gut degeneration in transgenic SPAM mice . Communications Biology vol. 5 , ( 1 ) Article 446 ,
( 2022 ) . Soluble brain homogenates from diverse human and mouse sources preferentially seed diffuse Aβ plaque pathology when injected into newborn mouse hosts . Free Neuropathology vol. 3 ,
( 2021 ) . Photodynamic studies reveal rapid formation and appreciable turnover of tau inclusions . Acta Neuropathologica vol. 141 , ( 3 ) 359 - 381 .
( 2020 ) . Utilizing minimally purified secreted rAAV for rapid and cost-effective manipulation of gene expression in the CNS . Molecular Neurodegeneration vol. 15 , ( 1 ) Article 15 ,
( 2019 ) . Organotypic brain slice cultures to model neurodegenerative proteinopathies . Molecular Neurodegeneration vol. 14 , ( 1 ) Article 45 ,
( 2019 ) . An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes . Journal of Experimental Medicine vol. 216 , ( 11 ) 2479 - 2491 .
( 2019 ) . rAAV-based brain slice culture models of Alzheimer’s and Parkinson’s disease inclusion pathologies . Journal of Experimental Medicine vol. 216 , ( 3 ) 539 - 555 .
( 2018 ) . SIRT1: A Novel Way to Target Tau? . The Journal of Neuroscience vol. 38 , ( 36 ) 7755 - 7757 .
( 2018 ) . Novel monoclonal antibodies targeting the microtubule-binding domain of human tau . PLOS ONE vol. 13 , ( 4 ) e0195211 - e0195211 .
( 2018 ) . Distinct differences in prion-like seeding and aggregation between Tau protein variants provide mechanistic insights into tauopathies . Journal of Biological Chemistry vol. 293 , ( 7 ) 2408 - 2421 .
( 2018 ) . Preparation of organotypic brain slice cultures for the study of Alzheimer's disease . F1000research vol. 7 ,
( 2017 ) . Inhibition of glycogen synthase kinase-3 by BTA-EG4 reduces tau abnormalities in an organotypic brain slice culture model of Alzheimer’s disease . Scientific Reports vol. 7 , ( 1 ) Article 7434 ,
( 2017 ) . Targeting psychologic stress signaling pathways in Alzheimer’s disease . Molecular Neurodegeneration vol. 12 , ( 1 ) Article 49 ,
( 2017 ) . Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures . Cell Death & Disease vol. 8 , ( 3 ) e2671 - e2671 .
( 2016 ) . Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer’s disease brain . Acta Neuropathologica Communications vol. 4 , ( 1 ) Article 34 ,
( 2015 ) . Constant light enhances synchrony among circadian clock cells and promotes behavioral rhythms in VPAC2-signaling deficient mice . Scientific Reports vol. 5 , ( 1 ) Article 14044 ,
( 2014 ) . Astrocytes and neuroinflammation in Alzheimer's disease . Biochemical Society Transactions vol. 42 , ( 5 ) 1321 - 1325 .
( 2013 ) . Calpain cleavage and inactivation of the sodium calcium exchanger‐3 occur downstream of <scp>A</scp>β in <scp>A</scp>lzheimer's disease . Aging Cell vol. 13 , ( 1 ) 49 - 59 .