Publications: DR Henrike Janssen

Downey J, Oliveira-Coelho A, Kiss MG, Laghlali G, Leunig A, Radkevich E, Halasz L, Umali M et al. ( 2026 ) . Influenza hijacks myeloid cells to inflict type-I interferon-fueled damage in the heart . Immunity

Nessel I, Tsang VSK, Schroth J, Janssen H ( 2026 ) . Immunometabolism, an emerging field in perioperative and critical care medicine: a narrative review . British Journal of Anaesthesia

Giannas E, Patel A, Dias P, Heath RJ, Sinclair R, Surman K, Milton A, Middleditch A et al. ( 2025 ) . Perioperative management of renin–angiotensin system inhibitors in patients undergoing elective major noncardiac surgery: a mixed model investigation using systematic review, meta-analysis, multicentre service evaluation, and national survey . British Journal of Anaesthesia vol. 135 , ( 4 ) 861 - 869 .

Janssen H, Dias P, Ahuja S, Alharbi S, Hiller L, Khan K, Iyer K, Sundar A et al. ( 2025 ) . Accuracy of continuous glucose monitoring during noncardiac surgery: a prospective, blinded observational multicentre cohort study . British Journal of Anaesthesia vol. 135 , ( 4 ) 912 - 919 .

Janssen H, Dias P, Hiller L, Hewson R, Pearse RM, Oliver NS, Jhanji S, Ackland GL et al. ( 2025 ) . Glucose variability and mode of anaesthesia in major noncardiac surgery (GlucoVITAL): study protocol for a randomised controlled trial . BJA Open vol. 14 ,

Schuster L, Zaradzki M, Janssen H, Gallenstein N, Etheredge M, Hofmann I, Weigand MA, Immenschuh S et al. ( 2025 ) . Heme oxygenase-1 modulates CD62E-dependent endothelial cell–monocyte interactions and mitigates HLA-I-induced transplant vasculopathy in mice . Frontiers in Immunology vol. 16 ,

Pinto BB, Shelley B, Dias P, Begum S, Ennahdi-Elidrissi F, Abbott TEF, Hewson R, Patel A et al. ( 2025 ) . Targeted heart rate control using the funny current inhibitor ivabradine to reduce morbidity in patients undergoing noncardiac surgery: study protocol for a phase 2a, triple-blind, placebo-controlled randomised trial . BJA Open vol. 13 ,

Janssen HJ, Pearse R, Giannas E, Patel A, Dias P, ABBOTT T, Ackland G ( 2024 ) . Perioperative management of renin-angiotensin aldosterone-system inhibitors in patients undergoing elective major non-cardiac surgery: A mixed model investigation of systematic review, meta-analysis, multicentre service evaluation and national survey .

Giannas E, Dias P, Janssen H, Ackland G, Pearse R, Abbott T ( 2024 ) . Clinical management of stopping or continuing perioperative angiotensin II converting enzyme inhibitors and/or angiotensin receptor blockers: a survey of clinical opinion . BJA Open vol. 12 ,

Janssen H, Jhanji S, Oliver NS, Ackland GL, Investigators FTG, Korbonits M, Henson S, Yeung J et al. ( 2024 ) . Ward monitoring 4.0: real-time metabolic insights from continuous glucose monitoring into perioperative organ dysfunction . British Journal of Anaesthesia vol. 132 , ( 5 ) 843 - 848 .

Janssen H, Koekkoek LL, Swirski FK ( 2023 ) . Effects of lifestyle factors on leukocytes in cardiovascular health and disease . Nature Reviews Cardiology vol. 21 , ( 3 ) 157 - 169 .

Kiss MG, Mindur JE, Yates AG, Lee D, Fullard JF, Anzai A, Poller WC, Christie KA et al. ( 2023 ) . Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis . Immunity vol. 56 , ( 7 ) 1502 - 1514.e8 .

Janssen H, Kahles F, Liu D, Downey J, Koekkoek LL, Roudko V, D'Souza D, McAlpine CS et al. ( 2023 ) . Monocytes re-enter the bone marrow during fasting and alter the host response to infection . Immunity vol. 56 , ( 4 ) 783 - 796.e7 .

McAlpine CS, Kiss MG, Zuraikat FM, Cheek D, Schiroli G, Amatullah H, Huynh P, Bhatti MZ et al. ( 2022 ) . Sleep exerts lasting effects on hematopoietic stem cell function and diversity . Journal of Experimental Medicine vol. 219 , ( 11 )

Janssen H, Wagner NM, Napp LC, Larmann J ( 2022 ) . Editorial: Targeting innate and adaptive immunity for improvement of cardiovascular disease . Frontiers in Physiology vol. 13 ,

Poller WC, Downey J, Mooslechner AA, Khan N, Li L, Chan CT, McAlpine CS, Xu C et al. ( 2022 ) . Brain motor and fear circuits regulate leukocytes during acute stress . Nature vol. 607 , ( 7919 ) 578 - 584 .

Murray JM, Pfeffer P, Seifert R, Hermann A, Handke J, Kummer L, Janssen H, Weigand MA et al. ( 2021 ) . Vesseg . Arteriosclerosis Thrombosis and Vascular Biology vol. 41 , ( 10 ) 2516 - 2522 .

McAlpine CS, Park J, Griciuc A, Kim E, Choi SH, Iwamoto Y, Kiss MG, Christie KA et al. ( 2021 ) . Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease . Nature vol. 595 , ( 7869 ) 701 - 706 .

Gillmann H-J, Dieding J, Schrimpf C, Janssen H, Sahlmann B, Rustum S, Aper T, Lichtinghagen R et al. ( 2020 ) . Prospective evaluation of preoperative lung ultrasound for prediction of perioperative outcome and myocardial injury in adult patients undergoing vascular surgery (LUPPO study) . Minerva Anestesiologica vol. 86 , ( 11 ) 1151 - 1160 .

Chan CT, Fenn AM, Harder NK, Mindur JE, McAlpine CS, Patel J, Valet C, Rattik S et al. ( 2020 ) . Liver X receptors are required for thymic resilience and T cell output . Journal of Experimental Medicine vol. 217 , ( 10 )

Handke J, Scholz AS, Dehne S, Krisam J, Gillmann H-J, Janssen H, Arens C, Espeter F et al. ( 2020 ) . Presepsin for pre-operative prediction of major adverse cardiovascular events in coronary heart disease patients undergoing noncardiac surgery: Post hoc analysis of the Leukocytes and Cardiovascular Peri-operative Events-2 (LeukoCAPE-2) Study . European Journal of Anaesthesiology vol. 37 , ( 10 ) 908 - 919 .

Larmann J, Handke J, Scholz AS, Dehne S, Arens C, Gillmann H-J, Uhle F, Motsch J et al. ( 2020 ) . Preoperative neutrophil to lymphocyte ratio and platelet to lymphocyte ratio are associated with major adverse cardiovascular and cerebrovascular events in coronary heart disease patients undergoing non-cardiac surgery . BMC Cardiovascular Disorders vol. 20 , ( 1 )

Janssen H, Felgner L, Kummer L, Gillmann H-J, Schrimpf C, Rustum S, Lichtinghagen R, Sahlmann B et al. ( 2020 ) . Sequential Surgical Procedures in Vascular Surgery Patients Are Associated With Perioperative Adverse Cardiac Events . Frontiers in Cardiovascular Medicine vol. 7 ,

Scholz AS, Handke J, Gillmann H-J, Zhang Q, Dehne S, Janssen H, Arens C, Espeter F et al. ( 2019 ) . Frontline Science: Low regulatory T cells predict perioperative major adverse cardiovascular and cerebrovascular events after noncardiac surgery . Journal of Leukocyte Biology vol. 107 , ( 5 ) 717 - 730 .

Janßen H, Dehne S, Giannitsis E, Weigand MA, Larmann J ( 2019 ) . Perioperative kardiovaskuläre Morbidität und Letalität bei nichtherzchirurgischen Eingriffen . Die Anaesthesiologie vol. 68 , ( 10 ) 653 - 664 .

Handke J, Scholz AS, Gillmann H-J, Janssen H, Dehne S, Arens C, Kummer L, Uhle F et al. ( 2019 ) . Elevated Presepsin Is Associated With Perioperative Major Adverse Cardiovascular and Cerebrovascular Complications in Elevated-Risk Patients Undergoing Noncardiac Surgery . Anesthesia & Analgesia vol. Publish Ahead of Print , ( &NA; )

Larmann J, Jurk K, Janssen H, Müller M, Herzog C, Lorenz A, Schmitz M, Nofer J-R et al. ( 2015 ) . Hepatic Overexpression of Soluble Urokinase Receptor (uPAR) Suppresses Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient (LDLR-/-) Mice . PLOS ONE vol. 10 , ( 8 )

Janssen H, Wagner CS, Demmer P, Callies S, Sölter G, Loghmani-khouzani H, Hu N, Schuett H et al. ( 2015 ) . Acute perioperative-stress-induced increase of atherosclerotic plaque volume and vulnerability to rupture in apolipoprotein-E-deficient mice is amenable to statin treatment and IL-6 inhibition . Disease Models & Mechanisms vol. 8 , ( 9 ) 1071 - 1080 .