Publications: P James Buchanan
Smith HS, Buchanan J, Goranitis I, IJzerman MJ, Lavelle TA, Marshall DA, Regier DA, Ungar WJ et al.
(
2025
)
.
Distributional Cost-Effectiveness Analysis in Genomic Medicine: Considerations for Addressing Health Equity
.
Value in Health
vol.
28
,
(
8
)
1213
-
1220
.
Sansom SL, Buchanan J, Dixon P, Peters M, Wordsworth S
(
2025
)
.
PCR42 Measuring Patient- and Carer-Reported Outcomes Following Genome Sequencing for Rare Disease Diagnosis: A Psychometric Assessment of Outcome Measurement Instruments
.
Value in Health
vol.
28
,
(
6
)
S317
-
S317
.
Buckell J, Madyiwa N, Hayward G, Middleton MR, Hobbs FDR, Buchanan J, Tsiachristas A, Nicholson BD
(
2025
)
.
Preferences for multi-cancer tests (MCTs) in primary care: discrete choice experiments of general practitioners and the general public in England
.
British Journal of Cancer
vol.
133
,
(
3
)
394
-
403
.
Buchanan J, Goranitis I, Weymann D
(
2025
)
.
The Health Economics of Genomic Technologies: A Growing Evidence Base on Value
.
Applied Health Economics and Health Policy
vol.
23
,
(
3
)
331
-
335
.
Horn R, Kerasidou A, Merchant J, Bale M, Banner N, Buchanan J, Cambon-Thomsen A, Chneiweiss H et al.
(
2025
)
.
The value of large-scale programmes in human genomics
.
European Journal of Human Genetics
vol.
33
,
(
5
)
563
-
569
.
Santos Gonzalez F, Ungar WJ, Buchanan J, Christodoulou J, Stark Z, Goranitis I
(
2025
)
.
Microcosting genomics: Challenges and opportunities
.
Genetics in Medicine
vol.
27
,
(
2
)
Article
101310
,
101310
-
101310
.
Smith HS, Regier DA, Goranitis I, Bourke M, IJzerman MJ, Degeling K, Montgomery T, Phillips KA et al.
(
2025
)
.
Approaches to Incorporation of Preferences into Health Economic Models of Genomic Medicine: A Critical Interpretive Synthesis and Conceptual Framework
.
Applied Health Economics and Health Policy
vol.
23
,
(
3
)
337
-
358
.
Mcleod M, Campbell A, Hayhoe B, Borek AJ, Tonkin-Crine S, Moore MV, Butler CC, Walker AS et al.
(
2024
)
.
How, why and when are delayed (back-up) antibiotic prescriptions used in primary care? A realist review integrating concepts of uncertainty in healthcare
.
BMC Public Health
vol.
24
,
(
1
)
Article
2820
,
Weymann D, Buckell J, Fahr P, Loewen R, Ehman M, Pollard S, Friedman JM, Stockler-Ipsiroglu S et al.
(
2024
)
.
Health Care Costs After Genome-Wide Sequencing for Children With Rare Diseases in England and Canada
.
JAMA Network Open
vol.
7
,
(
7
)
e2420842
-
e2420842
.
Baple EL, Scott RH, Banka S, Buchanan J, Fish L, Wynn S, Wilkinson D, Ellard S et al.
(
2024
)
.
Exploring the benefits, harms and costs of genomic newborn screening for rare diseases
.
Nature Medicine
vol.
30
,
(
7
)
1823
-
1825
.
Buckell J, Weymann D, Pollard S, Loewen R, Wordsworth S, Buchanan J, Regier DA
(
2024
)
.
PCR67 Exploring the Link Between Genomic Testing Decisions and Quality of Life When Diagnosing Rare Childhood Disorders: A Sequential Stated Choice Experiment
.
Value in Health
.
vol.
27
,
S307
-
S308
.
Roope LSJ, Morrell L, Buchanan J, Ledda A, Adler AI, Jit M, Walker AS, Pouwels KB et al.
(
2024
)
.
Overcoming challenges in the economic evaluation of interventions to optimise antibiotic use
.
Communications Medicine
vol.
4
,
(
1
)
Article
101
,
Lewis C, Boardman F, Buchanan J, Clark S, Gilchrist K, Hardelid P, Hunter A, Jones J et al.
(
2024
)
.
Exploring the feasibility, acceptability and impact of genomic newborn screening for rare diseases in England: A study protocol for the Generation Study - Process and Impact Evaluation
.
Marshall DA, Hua N, Buchanan J, Christensen KD, Frederix GWJ, Goranitis I, Ijzerman M, Jansen JP et al.
(
2024
)
.
Paving the path for implementation of clinical genomic sequencing globally: Are we ready?
.
Health Affairs Scholar
vol.
2
,
(
5
)
Article
qxae053
,
Nolan J, Buchanan J, Taylor J, Almeida J, Bedenham T, Blair E, Broadgate S, Butler S et al.
(
2024
)
.
Secondary (additional) findings from the 100,000 Genomes Project: Disease manifestation, health care outcomes, and costs of disclosure
.
Genetics in Medicine
vol.
26
,
(
3
)
Article
101051
,
101051
-
101051
.
Pan T, Wu Y, Buchanan J, Goranitis I
(
2023
)
.
QALYs and rare diseases: exploring the responsiveness of SF-6D, EQ-5D-5L and AQoL-8D following genomic testing for childhood and adult-onset rare genetic conditions in Australia
.
Health and Quality of Life Outcomes
vol.
21
,
(
1
)
Article
132
,
Barbosu S, Wordsworth S, Buckell J, Buchanan J
(
2023
)
.
Evaluating the Impact of Genome Sequencing on Healthcare Resource Use: Evidence from Cancer Patients
.
Academy of Management Proceedings
.
vol.
2023
,
Liao W, Coupland CAC, Burchardt J, Baldwin DR, Gleeson FV, Hippisley-Cox J, Gleeson F, Baldwin D et al.
(
2023
)
.
Predicting the future risk of lung cancer: development, and internal and external validation of the CanPredict (lung) model in 19·67 million people and evaluation of model performance against seven other risk prediction models
.
The Lancet Respiratory Medicine
vol.
11
,
(
8
)
685
-
697
.
Wiener EK, Buchanan J, Krause A, Lombard Z
(
2023
)
.
Retrospective file review shows limited genetic services fail most patients – an argument for the implementation of exome sequencing as a first-tier test in resource-constrained settings
.
Orphanet Journal of Rare Diseases
vol.
18
,
(
1
)
Article
81
,
Mitropoulou C, Fragoulakis V, Buchanan J, Wordsworth S, Patrinos GP
(
2023
)
.
Chapter 1 Introduction to economic evaluation in health sciences
.
Economic Evaluation in Genomic and Precision Medicine
,
Elsevier
(
2023
)
.
Economic Evaluation in Genomic and Precision Medicine
.
Elsevier
Mitropoulou C, Fragoulakis V, Buchanan J, Wordsworth S, Patrinos GP
(
2023
)
.
Introduction to economic evaluation in health sciences
.
Economic Evaluation in Genomic and Precision Medicine
,
Elsevier
Mitropoulou C, Wordsworth S, Buchanan J, Patrinos GP
(
2023
)
.
Preface
.
Economic Evaluation in Genomic and Precision Medicine
,
Elsevier
Wordsworth S, Doble B, Payne K, Buchanan J, Marshall D, McCabe C, Philips K, Fahr P et al.
(
2023
)
.
Using “big data” for economic evaluations in genomics
.
Economic Evaluation in Genomic and Precision Medicine
,
Elsevier
Buchanan J, Goranitis I, Slade I, Kerasidou A, Sheehan M, Sideri K, Wordsworth S
(
2022
)
.
Resource allocation in genetic and genomic medicine
.
Journal of Community Genetics
vol.
13
,
(
5
)
463
-
466
.
Pollard S, Weymann D, Chan B, Ehman M, Wordsworth S, Buchanan J, Hanna TP, Ho C et al.
(
2022
)
.
Defining a Core Data Set for the Economic Evaluation of Precision Oncology
.
Value in Health
vol.
25
,
(
8
)
1371
-
1380
.
Wiener E, Buchanan J, Lombard Z, Krause A
(
2022
)
.
Genetic services in a resource-constrained African setting – diagnostic odysseys, limited testing strategies and the need for exome sequencing
.
Buchanan J, Hill M, Vass CM, Hammond J, Riedijk S, Klapwijk JE, Harding E, Lou S et al.
(
2022
)
.
Factors that impact on women's decision‐making around prenatal genomic tests: An international discrete choice survey
.
Prenatal Diagnosis
vol.
42
,
(
7
)
934
-
946
.
Koleva-Kolarova R, Buchanan J, Vellekoop H, Huygens S, Versteegh M, Mölken MR-V, Szilberhorn L, Zelei T et al.
(
2022
)
.
Financing and Reimbursement Models for Personalised Medicine: A Systematic Review to Identify Current Models and Future Options
.
Applied Health Economics and Health Policy
vol.
20
,
(
4
)
501
-
524
.
Lewis C, Buchanan J, Clarke A, Clement E, Friedrich B, Hastings-Ward J, Hill M, Horn R et al.
(
2022
)
.
Mixed-methods evaluation of the NHS Genomic Medicine Service for paediatric rare diseases: study protocol
.
NIHR Open Research
vol.
1
,
23
-
23
.
Yang M, Roope LSJ, Buchanan J, Attema AE, Clarke PM, Walker AS, Wordsworth S
(
2022
)
.
Eliciting risk preferences that predict risky health behavior: A comparison of two approaches
.
Health Economics
vol.
31
,
(
5
)
836
-
858
.
Hammond J, Klapwijk JE, Riedijk S, Lou S, Ormond KE, Vogel I, Hui L, Sziepe E-J et al.
(
2022
)
.
Assessing women’s preferences towards tests that may reveal uncertain results from prenatal genomic testing: Development of attributes for a discrete choice experiment, using a mixed-methods design
.
PLOS ONE
vol.
17
,
(
1
)
e0261898
-
e0261898
.
Lewis C, Buchanan J, Clarke A, Clement E, Friedrich B, Hastings-Ward J, Hill M, Horn R et al.
(
2021
)
.
Mixed-methods evaluation of the NHS Genomic Medicine Service for paediatric rare diseases: study protocol
.
NIHR Open Research
vol.
1
,
23
-
23
.
(
2021
)
.
100,000 Genomes Pilot on Rare-Disease Diagnosis in Health Care — Preliminary Report
.
New England Journal of Medicine
vol.
385
,
(
20
)
1868
-
1880
.
Borek AJ, Campbell A, Dent E, Moore M, Butler CC, Holmes A, Walker AS, McLeod M et al.
(
2021
)
.
Development of an intervention to support the implementation of evidence-based strategies for optimising antibiotic prescribing in general practice
.
Implementation Science Communications
vol.
2
,
(
1
)
Article
104
,
Morrell L, Buchanan J, Roope LSJ, Pouwels KB, Butler CC, Hayhoe B, Tonkin-Crine S, McLeod M et al.
(
2021
)
.
Public preferences for delayed or immediate antibiotic prescriptions in UK primary care: A choice experiment
.
PLOS Medicine
vol.
18
,
(
8
)
e1003737
-
e1003737
.
Morrell L, Buchanan J, Rees S, Barker RW, Wordsworth S
(
2021
)
.
What Aspects of Illness Influence Public Preferences for Healthcare Priority Setting? A Discrete Choice Experiment in the UK
.
PharmacoEconomics
vol.
39
,
(
12
)
1443
-
1454
.
Buchanan J, Altunkaya J, Van Kinh N, Van Vinh Chau N, Trieu Ly V, Thi Thanh Thuy P, Hai Vinh V, Thi Hong Hanh D et al.
(
2021
)
.
Cost-Effectiveness of Amphotericin B Deoxycholate Versus Itraconazole for Induction Therapy of Talaromycosis in Human Immunodeficiency Virus–Infected Adults in Vietnam
.
Open Forum Infectious Diseases
vol.
8
,
(
7
)
Article
ofab357
,
Pollard S, Weymann D, Dunne J, Mayanloo F, Buckell J, Buchanan J, Wordsworth S, Friedman JM et al.
(
2021
)
.
Correction to: Toward the diagnosis of rare childhood genetic diseases: what do parents value most?
.
European Journal of Human Genetics
vol.
29
,
(
10
)
1589
-
1589
.
Pollard S, Weymann D, Dunne J, Mayanloo F, Buckell J, Buchanan J, Wordsworth S, Friedman JM et al.
(
2021
)
.
Toward the diagnosis of rare childhood genetic diseases: what do parents value most?
.
European Journal of Human Genetics
vol.
29
,
(
10
)
1491
-
1501
.
Buchanan J, Roope LSJ, Morrell L, Pouwels KB, Robotham JV, Abel L, Crook DW, Peto T et al.
(
2021
)
.
Preferences for Medical Consultations from Online Providers: Evidence from a Discrete Choice Experiment in the United Kingdom
.
Applied Health Economics and Health Policy
vol.
19
,
(
4
)
521
-
535
.
Phillips KA, Douglas MP, Wordsworth S, Buchanan J, Marshall DA
(
2021
)
.
Availability and funding of clinical genomic sequencing globally
.
BMJ Global Health
vol.
6
,
(
2
)
e004415
-
e004415
.
Borek AJ, Campbell A, Dent E, Butler CC, Holmes A, Moore M, Walker AS, McLeod M et al.
(
2021
)
.
Implementing interventions to reduce antibiotic use: a qualitative study in high-prescribing practices
.
BMC Family Practice
vol.
22
,
(
1
)
Article
25
,
Gaille M, Horn R
(
2021
)
.
The ethics of genomic medicine: redefining values and norms in the UK and France
.
European Journal of Human Genetics
vol.
29
,
(
5
)
780
-
788
.
Koleva-Kolarova R, Buchanan J, Wordsworth S, Tsiachristas A
(
2020
)
.
RE1 Financing and Reimbursement for Personalised Medicine - Are WE There YET?
.
Value in Health
.
vol.
23
,
S756
-
S756
.
Pouwels KB, Roope LSJ, Buchanan J, Morrell L, Tonkin-Crine S, Peters M, Jones LF, Castro-Sánchez E et al.
(
2020
)
.
Awareness of Appropriate Antibiotic Use in Primary Care for Influenza-Like Illness: Evidence of Improvement from UK Population-Based Surveys
.
Antibiotics
vol.
9
,
(
10
)
690
-
690
.
Morrell L, Buchanan J, Roope L, Pouwels K, Butler C, Hayhoe B, Moore M, Tonkin-Crine S et al.
(
2020
)
.
Delayed Antibiotic Prescription by General Practitioners in the UK: A Stated-Choice Study
.
Antibiotics
vol.
9
,
(
9
)
608
-
608
.
Phillips K, Wordsworth S, Regier D, Marshall D, Douglas MP, Buchanan J
(
2020
)
.
PCV3 Global Landscape of Clinical Genomic Sequencing: Who, Where, and How?
.
Value in Health Regional Issues
vol.
22
,
S26
-
S26
.
Roope LSJ, Buchanan J, Morrell L, Pouwels KB, Sivyer K, Mowbray F, Abel L, Cross ELA et al.
(
2020
)
.
Why do hospital prescribers continue antibiotics when it is safe to stop? Results of a choice experiment survey
.
BMC Medicine
vol.
18
,
(
1
)
Article
196
,
Marshall DA, Grazziotin LR, Regier DA, Wordsworth S, Buchanan J, Phillips K, Ijzerman M
(
2020
)
.
Addressing Challenges of Economic Evaluation in Precision Medicine Using Dynamic Simulation Modeling
.
Value in Health
vol.
23
,
(
5
)
566
-
573
.
Pouwels KB, Vansteelandt S, Batra R, Edgeworth J, Wordsworth S, Robotham JV, Anyanwu PE, Borek A et al.
(
2020
)
.
Estimating the Effect of Healthcare-Associated Infections on Excess Length of Hospital Stay Using Inverse Probability–Weighted Survival Curves
.
Clinical Infectious Diseases
vol.
71
,
(
9
)
e415
-
e420
.
Morrison M, Teare H, Bertier G, Buchanan J, Bylstra Y, Gaff C, Jackson L, Kato K et al.
(
2020
)
.
Chapter 8 Implications of secondary findings for clinical contexts
.
Secondary Findings in Genomic Research
,
Elsevier
Morrison M, Teare H, Bertier G, Buchanan J, Bylstra Y, Gaff C, Jackson L, Kato K et al.
(
2020
)
.
Implications of secondary findings for clinical contexts
.
Secondary Findings in Genomic Research
,
Elsevier
Schwarze K, Buchanan J, Fermont JM, Dreau H, Tilley MW, Taylor JM, Antoniou P, Knight SJL et al.
(
2020
)
.
The complete costs of genome sequencing: a microcosting study in cancer and rare diseases from a single center in the United Kingdom
.
Genetics in Medicine
vol.
22
,
(
1
)
85
-
94
.
Fahr P, Buchanan J, Wordsworth S
(
2019
)
.
A Review of Health Economic Studies Comparing Traditional and Massively Parallel Sequencing Diagnostic Pathways for Suspected Genetic Disorders
.
PharmacoEconomics
vol.
38
,
(
2
)
143
-
158
.
Buchanan J, Blair E, Thomson KL, Ormondroyd E, Watkins H, Taylor JC, Wordsworth S
(
2019
)
.
Do health professionals value genomic testing? A discrete choice experiment in inherited cardiovascular disease
.
European Journal of Human Genetics
vol.
27
,
(
11
)
1639
-
1648
.
Copsey B, Buchanan J, Fitzpatrick R, Lamb SE, Dutton SJ, Cook JA
(
2019
)
.
Duration of Treatment Effect Should Be Considered in the Design and Interpretation of Clinical Trials: Results of a Discrete Choice Experiment
.
Medical Decision Making
vol.
39
,
(
4
)
461
-
473
.
Roope LSJ, Smith RD, Pouwels KB, Buchanan J, Abel L, Eibich P, Butler CC, Tan PS et al.
(
2019
)
.
The challenge of antimicrobial resistance: What economics can contribute
.
Science
vol.
364
,
(
6435
)
Article
eaau4679
,
Fahr P, Buchanan J, Wordsworth S
(
2019
)
.
A Review of the Challenges of Using Biomedical Big Data for Economic Evaluations of Precision Medicine
.
Applied Health Economics and Health Policy
vol.
17
,
(
4
)
443
-
452
.
Leal J, Manetti S, Buchanan J
(
2019
)
.
Correction to: The Impact of Hospital Costing Methods on Cost-Effectiveness Analysis: A Case Study
.
PharmacoEconomics
vol.
37
,
(
6
)
867
-
867
.
Yang Y, Abel L, Buchanan J, Fanshawe T, Shinkins B
(
2018
)
.
Use of Decision Modelling in Economic Evaluations of Diagnostic Tests: An Appraisal and Review of Health Technology Assessments in the UK
.
PharmacoEconomics - Open
vol.
3
,
(
3
)
281
-
291
.
Buchanan J, Wordsworth S
(
2018
)
.
Evaluating the Outcomes Associated with Genomic Sequencing: A Roadmap for Future Research
.
PharmacoEconomics - Open
vol.
3
,
(
2
)
129
-
132
.
Schwarze K, Buchanan J, Taylor JC, Wordsworth S
(
2018
)
.
Are whole-exome and whole-genome sequencing approaches cost-effective? A systematic review of the literature
.
Genetics in Medicine
vol.
20
,
(
10
)
1122
-
1130
.
Phillips KA, Deverka PA, Marshall DA, Wordsworth S, Regier DA, Christensen KD, Buchanan J
(
2018
)
.
Methodological Issues in Assessing the Economic Value of Next-Generation Sequencing Tests: Many Challenges and Not Enough Solutions
.
Value in Health
vol.
21
,
(
9
)
1033
-
1042
.
Wordsworth S, Doble B, Payne K, Buchanan J, Marshall DA, McCabe C, Regier DA
(
2018
)
.
Using “Big Data” in the Cost-Effectiveness Analysis of Next-Generation Sequencing Technologies: Challenges and Potential Solutions
.
Value in Health
vol.
21
,
(
9
)
1048
-
1053
.
Regier DA, Weymann D, Buchanan J, Marshall DA, Wordsworth S
(
2018
)
.
Valuation of Health and Nonhealth Outcomes from Next-Generation Sequencing: Approaches, Challenges, and Solutions
.
Value in Health
vol.
21
,
(
9
)
1043
-
1047
.
Leal J, Manetti S, Buchanan J
(
2018
)
.
The Impact of Hospital Costing Methods on Cost-Effectiveness Analysis: A Case Study
.
PharmacoEconomics
vol.
36
,
(
10
)
1263
-
1272
.
Schwarze K, Buchanan J, Taylor JC, Wordsworth S
(
2018
)
.
Are whole Exome and whole Genome Sequencing Approaches Cost-Effective? A Systematic Review of the Literature
.
Value in Health
vol.
21
,
S100
-
S100
.
Parker B, Buchanan J, Wordsworth S, Keshav S, George B, East JE
(
2017
)
.
Surgery versus surveillance in ulcerative colitis patients with endoscopically invisible low-grade dysplasia: a cost-effectiveness analysis
.
Gastrointestinal Endoscopy
vol.
86
,
(
6
)
1088
-
1099.e5
.
Buchanan J, Wordsworth S, Clifford R, Robbe P, Taylor JC, Schuh A, Knight SJL
(
2017
)
.
Using Genomic Information to Guide Ibrutinib Treatment Decisions in Chronic Lymphocytic Leukaemia: A Cost-Effectiveness Analysis
.
PharmacoEconomics
vol.
35
,
(
8
)
845
-
858
.
Monahan KJ, Alsina D, Bach S, Buchanan J, Burn J, Clark S, Dawson P, De Souza B et al.
(
2017
)
.
Urgent improvements needed to diagnose and manage Lynch syndrome
.
BMJj1388
-
j1388
.
Hollowell J, Li Y, Malouf R, Buchanan J
(
2016
)
.
Women’s birth place preferences in the United Kingdom: a systematic review and narrative synthesis of the quantitative literature
.
BMC Pregnancy and Childbirth
vol.
16
,
(
1
)
Article
213
,
Buchanan J, Wordsworth S, Schuh A
(
2016
)
.
Patients’ Preferences for Genomic Diagnostic Testing in Chronic Lymphocytic Leukaemia: A Discrete Choice Experiment
.
The Patient - Patient-Centered Outcomes Research
vol.
9
,
(
6
)
525
-
536
.
Wordsworth S, Buchanan J, Towse A
(
2016
)
.
Health Economic Perspectives of Genomics
.
Genomics and Society
,
Elsevier
Peters JL, Cooper C, Buchanan J
(
2015
)
.
Evidence used in model-based economic evaluations for evaluating pharmacogenetic and pharmacogenomic tests: a systematic review protocol
.
BMJ Open
vol.
5
,
(
11
)
e008465
-
e008465
.
Buchanan J, Wordsworth S, Taylor J, Jewell D
(
2015
)
.
PTU-029 Managing the long-term care of inflammatory bowel disease patients: the cost to European health care providers
.
Gut
vol.
59
,
(
Suppl 1
)
A60.1
-
A60
.
Buchanan J, Wordsworth S, O'Connor L, Pike G, Walker AS, Wilcox MH, Crook DW
(
2015
)
.
Management of patients with suspected infectious diarrhoea in hospitals in England
.
Journal of Hospital Infection
vol.
90
,
(
3
)
199
-
207
.
Parker B, Buchanan J, Wordsworth S, East J, Keshav S, George B
(
2015
)
.
OC-014 Management of low-grade dysplasia in ulcerative colitis in the uk national health service: the cost-effectiveness of immediate surgery versus ongoing surveillance
.
Gut
vol.
64
,
(
Suppl 1
)
A7.3
-
A8
.
Buchanan J, Wordsworth S
(
2015
)
.
Welfarism Versus Extra-Welfarism: Can the Choice of Economic Evaluation Approach Impact on the Adoption Decisions Recommended by Economic Evaluation Studies?
.
PharmacoEconomics
vol.
33
,
(
6
)
571
-
579
.
Pankhurst L, Macfarlane-Smith L, Buchanan J, Anson L, Davies K, O’Connor L, Ashwin H, Pike G et al.
(
2014
)
.
Can rapid integrated polymerase chain reaction-based diagnostics for gastrointestinal pathogens improve routine hospital infection control practice? A diagnostic study
.
Health Technology Assessment
vol.
18
,
(
53
)
1
-
167
.
Buchanan J, Wordsworth S, Schuh A
(
2013
)
.
Issues Surrounding the Health Economic Evaluation of Genomic Technologies
.
Pharmacogenomics
vol.
14
,
(
15
)
1833
-
1847
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