Publications: PROF Paul Evans

Wang Z, Chen S, Feng X, Chen X, Evans PC, Strijdom H, Ding Y, Weng J et al. ( 2025 ) . GLM7 – A Novel Composite Glycolipid Index Derived from Routine Health Indicators for Enhanced Diagnosis and Prediction of Multimorbidity . Advanced Science Article e10552 ,

Chen M-J, Zhang Z-D, Zhang F-S, Evans PC, Strijdom H, Xu S-W ( 2025 ) . Isoginkgetin, a natural biflavonoid from Ginkgo biloba, inhibits inflammatory response in endothelial cells via suppressing NF-κB activation . Acta Pharmacologica Sinica

Wei S, Evans PC, Strijdom H, Xu S ( 2025 ) . HIV infection, antiretroviral therapy and vascular dysfunction: Effects, mechanisms and treatments . Pharmacological Research vol. 217 , Article 107812 , 107812 - 107812 .

Tardajos-Ayllon B, Diagbouga M, Edsfeldt A, Kalucka J, Serbanovic-Canic J, Chambers E, Sun J, Gialeli C et al. ( 2025 ) . TWIST1 drives endothelial-to-mesenchymal-transition to stabilize atherosclerotic plaques .

Paillard M, Abdellatif M, Andreadou I, Bär C, Bertrand L, Brundel BJJM, Chiva‐Blanch G, Davidson SM et al. ( 2025 ) . Mitochondrial targets in ischaemic heart disease and heart failure, and their potential for a more efficient clinical translation. A scientific statement of the <scp>ESC</scp> Working Group on Cellular Biology of the Heart and the <scp>ESC</scp> Working Group on Myocardial Function . European Journal of Heart Failure Article ejhf.3674 ,

Sun L, Leng R, Liu M, Su M, He Q, Zhang Z, Liu Z, Wang Z et al. ( 2025 ) . Endothelial MICU1 protects against vascular inflammation and atherosclerosis by inhibiting mitochondrial calcium uptake . Journal of Clinical Investigation vol. 135 , ( 7 ) Article e181928 ,

Zhang Z, Chen M, Xu Y, Wang Z, Liu Z, He C, Zhang F, Feng X et al. ( 2025 ) . A natural small molecule isoginkgetin alleviates hypercholesterolemia and atherosclerosis by targeting ACLY . Theranostics vol. 15 , ( 10 ) 4325 - 4344 .

Davidson SM, Andreadou I, Antoniades C, Bartunek J, Basso C, Brundel BJJM, Byrne RA, Chiva-Blanch G et al. ( 2025 ) . Opportunities and challenges for the use of human samples in translational cardiovascular research: a scientific statement of the ESC Working Group on Cellular Biology of the Heart, the ESC Working Group on Cardiovascular Surgery, the ESC Council on Basic Cardiovascular Science, the ESC Scientists of Tomorrow, the European Association of Percutaneous Cardiovascular Interventions of the ESC, and the Heart Failure Association of the ESC . Cardiovascular Research vol. 121 , ( 5 ) 702 - 729 .

Tardajos Ayllon B, Bowden N, Souilhol C, Darwish H, Tian S, Duckworth C, Pritchard DM, Xu S et al. ( 2025 ) . Endothelial c-REL orchestrates atherosclerosis at regions of disturbed flow through crosstalk with TXNIP-p38 and non-canonical NF-κB pathways . Cardiovascular Research vol. 121 , ( 5 ) 748 - 759 .

Liberale L, Tual-Chalot S, Sedej S, Ministrini S, Georgiopoulos G, Grunewald M, Bäck M, Bochaton-Piallat M-L et al. ( 2025 ) . Roadmap for alleviating the manifestations of ageing in the cardiovascular system . Nature Reviews Cardiology vol. 22 , ( 8 ) 577 - 605 .

Su M, Zhao W, Jiang H, Zhao Y, Liao Z, Liu Z, Xu M, Jiang S et al. ( 2025 ) . Endothelial IGFBP6 suppresses vascular inflammation and atherosclerosis . Nature Cardiovascular Research vol. 4 , ( 2 ) 145 - 162 .

Bowley G, Irving S, Hoefer I, Wilkinson R, Pasterkamp G, Darwish HMS, White S, Francis SE et al. ( 2024 ) . Zebrafish model for functional screening of flow-responsive genes controlling endothelial cell proliferation . Scientific Reports vol. 14 , ( 1 ) Article 30130 ,

Boldock L, Inzoli A, Bonardelli S, Hsiao S, Marzo A, Narracott A, Gunn J, Dubini G et al. ( 2024 ) . Correction: Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents . PLOS ONE vol. 19 , ( 11 ) e0314392 - e0314392 .

Zhou Z, Korteland S-A, Tardajos-Ayllon B, Wu J, Chambers E, Weninck J, Simons M, Dunning M et al. ( 2024 ) . Shear stress is uncoupled from atheroprotective KLK10 in atherosclerotic plaques . Atherosclerosis vol. 398 , Article 118622 , 118622 - 118622 .

Pirri D, Tian S, Tardajos-Ayllon B, Irving SE, Donati F, Allen SP, Mammoto T, Vilahur G et al. ( 2024 ) . EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites Through Endothelial Fatty Acid Uptake . Circulation Research vol. 135 , ( 8 ) 822 - 837 .

X S, Aitken C, Mehta V, Tardajos-Ayllon B, Serbanovic-Canic J, Zhu J, Miao B, Tzima E et al. ( 2024 ) . Controversy in mechanotransduction – the role of endothelial cell–cell junctions in fluid shear stress sensing . Journal of Cell Science vol. 137 , ( 17 ) Article jcs262348 ,

Zhao Y, Wang L, Huang Y, Evans PC, Little PJ, Tian X, Weng J, Xu S ( 2024 ) . Anthocyanins in Vascular Health and Disease: Mechanisms of Action and Therapeutic Potential . Journal of Cardiovascular Pharmacology vol. 84 , ( 3 ) 289 - 302 .

Sun L, Leng R, He Q, Su M, Zhang Z, Liu Z, Wang Z, Jiang H et al. ( 2024 ) . Endothelial MICU1 protects against vascular inflammation and atherosclerosis by inhibiting mitochondrial calcium uptake .

Wentzel JJ, Bos D, White SJ, van der Heiden K, Kavousi M, Evans PC ( 2024 ) . Sex-related differences in coronary and carotid vessel geometry, plaque composition and shear stress obtained from imaging . Atherosclerosis vol. 395 , Article 117616 , 117616 - 117616 .

Tian S, Evans PC ( 2024 ) . BMPER regulates arterial adaptation to flow . Nature Cardiovascular Research vol. 3 , ( 7 ) 777 - 779 .

Xu M-Y, Xu J-J, Kang L-J, Liu Z-H, Su M-M, Zhao W-Q, Wang Z-H, Sun L et al. ( 2024 ) . Urolithin A promotes atherosclerotic plaque stability by limiting inflammation and hypercholesteremia in Apolipoprotein E–deficient mice . Acta Pharmacologica Sinica vol. 45 , ( 11 ) 2277 - 2289 .

Wagner R, Carré MJ, Perrault CM, Evans PC, Lewis R ( 2024 ) . Assessing friction and damage of cell monolayers on soft substrates\n <i>in vitro</i> . Journal of The Royal Society Interface vol. 21 , ( 215 ) Article 20230696 ,

Wei S, Wang L, Evans PC, Xu S ( 2024 ) . NAFLD and NASH: etiology, targets and emerging therapies . Drug Discovery Today vol. 29 , ( 3 ) Article 103910 , 103910 - 103910 .

Pirri D, Tian S, Tardajos-Ayllon B, Irving S, Donati F, Allen SP, Mammoto T, Vilahur G et al. ( 2023 ) . EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites through Endothelial Fatty Acid Uptake .

Evans PC, Pearson J ( 2023 ) . Editorial overview: Recent insights into the multifaceted physiology of the endothelial cell and its modulated functions in pathology . Current Opinion in Physiology vol. 36 , Article 100715 , 100715 - 100715 .

Alfaidi M, Evans PC, Pickering JG ( 2023 ) . Editorial: Endothelial-to-mesenchymal transition in cardiovascular disease . Frontiers in Cardiovascular Medicine vol. 10 , Article 1290050 ,

Tardajos-Ayllon B, Diagbouga M, Evans PC ( 2023 ) . BS29 Endothelial TWIST1 enhances features of atherosclerotic plaque stability . Basic Science . Conference: British Cardiovascular Society Annual Conference, ‘Future-proofing Cardiology for the next 10 years’, 5–7 June 2023A264.3 - A265 .

Tian S, Pirri D, Tardajos-Ayllon B, Fragiadaki M, Evans PC ( 2023 ) . BS2 Flow-regulated EPAS1 limits atherosclerosis via metabolic control of endothelial proliferation . Basic Science . Conference: British Cardiovascular Society Annual Conference, ‘Future-proofing Cardiology for the next 10 years’, 5–7 June 2023A247.2 - A247 .

( 2023 ) . Correction to: EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 43 , ( 6 )

Li X, Souilhol C, Canham L, Jia X, Diagbouga M, Ayllon BT, Serbanovic-Canic J, Evans PC ( 2023 ) . DLL4 promotes partial endothelial-to-mesenchymal transition at atherosclerosis-prone regions of arteries . Vascular Pharmacology vol. 150 , Article 107178 , 107178 - 107178 .

Canham L, Sendac S, Diagbouga MR, Wolodimeroff E, Pirri D, Tardajos Ayllon B, Feng S, Souilhol C et al. ( 2023 ) . EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 43 , ( 4 ) 547 - 561 .

de Winther MPJ, Bäck M, Evans P, Gomez D, Goncalves I, Jørgensen HF, Koenen RR, Lutgens E et al. ( 2022 ) . Translational opportunities of single-cell biology in atherosclerosis . European Heart Journal vol. 44 , ( 14 ) 1216 - 1230 .

Souilhol C, Tardajos Ayllon B, Li X, Diagbouga MR, Zhou Z, Canham L, Roddie H, Pirri D et al. ( 2022 ) . JAG1-NOTCH4 mechanosensing drives atherosclerosis . Science Advances vol. 8 , ( 35 ) Article eabo7958 ,

Evans PC, Davidson SM, Wojta J, Bäck M, Bollini S, Brittan M, Catapano AL, Chaudhry B et al. ( 2022 ) . From novel discovery tools and biomarkers to precision medicine—basic cardiovascular science highlights of 2021/22 . Cardiovascular Research vol. 118 , ( 13 ) 2754 - 2767 .

Boldock L, Inzoli A, Bonardelli S, Hsiao S, Marzo A, Narracott A, Gunn J, Dubini G et al. ( 2022 ) . Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents . PLOS ONE vol. 17 , ( 7 ) e0271469 - e0271469 .

Zhou Z, Wu J, Wentzel J, Schenkel T, Diagbouga M, Fragiadaki M, Simons M, Evans P ( 2022 ) . BS21 Endothelial cell profile in responses to high shear stress is different in healthy arteries and plaques . Basic science . Conference: British Cardiovascular Society Annual Conference, ‘100 years of Cardiology’, 6–8 June 2022A158 - A159 .

Chen Y, Evans PC, Wilkinson RN ( 2022 ) . A Workflow to Track and Analyze Endothelial Migration During Vascular Development in Zebrafish Embryos Using Lightsheet Microscopy . Methods in Molecular Biology , Springer US

Arbustini E, Behr ER, Carrier L, van Duijn C, Evans P, Favalli V, van der Harst P, Haugaa KH et al. ( 2022 ) . Interpretation and actionability of genetic variants in cardiomyopathies: a position statement from the European Society of Cardiology Council on cardiovascular genomics . European Heart Journal vol. 43 , ( 20 ) 1901 - 1916 .

Iqbal J, Chamberlain J, Alfaidi M, Hughes M, Alizadeh T, Casbolt H, Evans P, Mann B et al. ( 2021 ) . Carbon Monoxide Releasing Molecule A1 Reduces Myocardial Damage After Acute Myocardial Infarction in a Porcine Model . Journal of Cardiovascular Pharmacology vol. 78 , ( 5 ) e656 - e661 .

Chiva-Blanch G, Evans PC ( 2021 ) . Scientists on the Spot: A matter of blood flow . Cardiovascular Research vol. 117 , ( 12 ) e162 - e163 .

Bowley G, Chico TJA, Serbanovic-Canic J, Evans PC ( 2021 ) . Quantifying endothelial cell proliferation in the zebrafish embryo . F1000Research vol. 10 , 1032 - 1032 .

Kugler E, Snodgrass R, Bowley G, Plant K, Serbanovic-Canic J, Hamilton N, Evans PC, Chico T et al. ( 2021 ) . The effect of absent blood flow on the zebrafish cerebral and trunk vasculature . Vascular Biology vol. 3 , ( 1 ) 1 - 16 .

Kraler S, Libby P, Evans PC, Akhmedov A, Schmiady MO, Reinehr M, Camici GG, Lüscher TF ( 2021 ) . Resilience of the Internal Mammary Artery to Atherogenesis: Shifting From Risk to Resistance to Address Unmet Needs . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 41 , ( 8 ) 2237 - 2251 .

Chen Y, Jiang Z, Fisher KH, Kim HR, Evans PC, Wilkinson RN ( 2021 ) . Blood flow coordinates collective endothelial cell migration during vascular plexus formation and promotes angiogenic sprout regression via <i>vegfr3/flt4</i> .

Davidson SM, Padró T, Bollini S, Vilahur G, Duncker DJ, Evans PC, Guzik T, Hoefer IE et al. ( 2021 ) . Progress in cardiac research: from rebooting cardiac regeneration to a complete cell atlas of the heart . Cardiovascular Research vol. 117 , ( 10 ) 2161 - 2174 .

Evans P, Wojta J, Hoefer IE, Waltenberger J, Guzik T, Badimon L ( 2021 ) . <b>Erratum to:</b> The year in basic vascular biology research: from mechanoreceptors and neutrophil extracellular traps to smartphone data and omics . Cardiovascular Research vol. 117 , ( 9 ) 2107 - 2107 .

Ayllón BT, Souilhol C, Oakley F, Evans PC ( 2021 ) . A c-REL drives atherosclerosis at sites of disturbed blood flow . Young investigators award . Conference: British Cardiovascular Society Virtual Annual Conference, ‘Cardiology and the Environment’, 7–10 June 2021A176.1 - A176 .

Bowley G, Evans P, Serbanovic-Canic J, Chico T ( 2021 ) . BS15 Using zebrafish embryos to identify genes that regulate endothelial proliferation . Basic science . Conference: British Cardiovascular Society Virtual Annual Conference, ‘Cardiology and the Environment’, 7–10 June 2021A163.2 - A164 .

Zhou Z, Van-Hateren N, Francis S, Fragiadaki M, Evans P ( 2021 ) . BS30 Light sheet imaging to analyse the spatial distribution of proteins in atherosclerotic plaques . Basic science . Conference: British Cardiovascular Society Virtual Annual Conference, ‘Cardiology and the Environment’, 7–10 June 2021A172.2 - A173 .

Bowley G, Kugler E, Wilkinson R, Lawrie A, van Eeden F, Chico TJA, Evans PC, Noël ES et al. ( 2021 ) . Zebrafish as a tractable model of human cardiovascular disease . British Journal of Pharmacology vol. 179 , ( 5 ) 900 - 917 .

Ward AO, Sala-Newby GB, Ladak S, Angelini GD, Caputo M, Suleiman M-S, Evans PC, George SJ et al. ( 2021 ) . Nrf2-Keap-1 imbalance under acute shear stress induces inflammatory response in venous endothelial cells . Perfusion vol. 37 , ( 6 ) 582 - 589 .

Evans P, Wojta J, Hoefer IE, Waltenberger J, Guzik T, Badimon L, Weber C ( 2021 ) . The year in basic vascular biology research: from mechanoreceptors and neutrophil extracellular traps to smartphone data and omics . Cardiovascular Research vol. 117 , ( 8 ) 1814 - 1822 .

Wagner RMF, Maiti R, Carré MJ, Perrault CM, Evans PC, Lewis R ( 2021 ) . Bio-tribology of Vascular Devices: A Review of Tissue/Device Friction Research . Biotribology vol. 25 , Article 100169 , 100169 - 100169 .

An W, Luong LA, Bowden NP, Yang M, Wu W, Zhou X, Liu C, Niu K et al. ( 2021 ) . Cezanne is a critical regulator of pathological arterial remodelling by targeting β-catenin signalling . Cardiovascular Research vol. 118 , ( 2 ) 638 - 653 .

Wang M, Murdoch CE, Brewer AC, Ivetic A, Evans P, Shah AM, Zhang M ( 2021 ) . Endothelial NADPH oxidase 4 protects against angiotensin II‐induced cardiac fibrosis and inflammation . ESC Heart Failure vol. 8 , ( 2 ) 1427 - 1437 .

Evans PC, Fragiadaki M, Morris PD, Serbanovic-Canic J ( 2020 ) . Shear stress: the dark energy of atherosclerotic plaques . Cardiovascular Research vol. 117 , ( 8 ) 1811 - 1813 .

Ward AO, Angelini GD, Caputo M, Evans PC, Johnson JL, Suleiman MS, Tulloh RM, George SJ et al. ( 2020 ) . NF-κB inhibition prevents acute shear stress-induced inflammation in the saphenous vein graft endothelium . Scientific Reports vol. 10 , ( 1 ) Article 15133 ,

Dweck MR, Maurovich-Horvat P, Leiner T, Cosyns B, Fayad ZA, Gijsen FJH, Van der Heiden K, Kooi ME et al. ( 2020 ) . Contemporary rationale for non-invasive imaging of adverse coronary plaque features to identify the vulnerable patient: a Position Paper from the European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology and the European Association of Cardiovascular Imaging . European Heart Journal - Cardiovascular Imaging vol. 21 , ( 11 ) 1177 - 1183 .

Pirri D, Fragiadaki M, Evans PC ( 2020 ) . Diabetic atherosclerosis: is there a role for the hypoxia-inducible factors? . Bioscience Reports vol. 40 , ( 8 ) Article BSR20200026 ,

Evans PC, Rainger GE, Mason JC, Guzik TJ, Osto E, Stamataki Z, Neil D, Hoefer IE et al. ( 2020 ) . Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science . Cardiovascular Research vol. 116 , ( 14 ) 2177 - 2184 .

Kugler E, Snodgrass R, Bowley G, Plant K, Serbanovic-Canic J, Evans PC, Chico T, Armitage P ( 2020 ) . The effect of absent blood flow on the zebrafish cerebral and trunk vasculature .

Morris PD, Gosling R, Zwierzak I, Evans H, Aubiniere-Robb L, Czechowicz K, Evans PC, Hose DR et al. ( 2020 ) . A novel method for measuring absolute coronary blood flow and microvascular resistance in patients with ischaemic heart disease . Cardiovascular Research vol. 117 , ( 6 ) 1567 - 1577 .

Naase H, Harling L, Kidher E, Sepehripour A, Nguyen B, Kapelouzou A, Cokkinos D, Stavridis G et al. ( 2020 ) . Toll-like receptor 9 and the inflammatory response to surgical trauma and cardiopulmonary bypass . Journal of Cardiothoracic Surgery vol. 15 , ( 1 ) Article 137 ,

Souilhol C, Li X, Canham L, Roddie H, Pirri D, Ayllon BT, Chambers EV, Dunning MJ et al. ( 2020 ) . JAG1-NOTCH4 Mechanosensing Drives Atherosclerosis .

Alexander Y, Osto E, Schmidt-Trucksäss A, Shechter M, Trifunovic D, Duncker DJ, Aboyans V, Bäck M et al. ( 2020 ) . Endothelial function in cardiovascular medicine: a consensus paper of the European Society of Cardiology Working Groups on Atherosclerosis and Vascular Biology, Aorta and Peripheral Vascular Diseases, Coronary Pathophysiology and Microcirculation, and Thrombosis . Cardiovascular Research vol. 117 , ( 1 ) 29 - 42 .

Patera F, Hautbergue GM, Wilson P, Evans PC, Ong ACM, Fragiadaki M ( 2020 ) . <i>Ankhd1</i>enhances polycystic kidney disease development via promoting proliferation and fibrosis .

Mahmoud MM, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J et al. ( 2020 ) . Author Correction: Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail . Scientific Reports vol. 10 , ( 1 ) Article 3870 ,

Gomez I, Ward B, Souilhol C, Recarti C, Ariaans M, Johnston J, Burnett A, Mahmoud M et al. ( 2020 ) . Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium . Nature Communications vol. 11 , ( 1 ) Article 214 ,

Zun PS, Narracott AJ, Evans PC, van Rooij BJM, Hoekstra AG ( 2019 ) . A particle-based model for endothelial cell migration under flow conditions . Biomechanics and Modeling in Mechanobiology vol. 19 , ( 2 ) 681 - 692 .

Gijsen F, Katagiri Y, Barlis P, Bourantas C, Collet C, Coskun U, Daemen J, Dijkstra J et al. ( 2019 ) . Expert recommendations on the assessment of wall shear stress in human coronary arteries: existing methodologies, technical considerations, and clinical applications . European Heart Journal vol. 40 , ( 41 ) 3421 - 3433 .

Souilhol C, Gauci I, Feng S, Tardajos Ayllon B, Mahmoud M, Canham L, Fragiadaki M, Serbanovic-Canic J et al. ( 2019 ) . Homeobox B9 integrates bone morphogenic protein 4 with inflammation at atheroprone sites . Cardiovascular Research vol. 116 , ( 7 ) 1300 - 1310 .

Souilhol C, Serbanovic-Canic J, Fragiadaki M, Chico TJ, Ridger V, Roddie H, Evans PC ( 2019 ) . Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes . Nature Reviews Cardiology vol. 17 , ( 1 ) 52 - 63 .

Ketelhuth DFJ, Lutgens E, Bäck M, Binder CJ, Van den Bossche J, Daniel C, Dumitriu IE, Hoefer I et al. ( 2019 ) . Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology . Cardiovascular Research vol. 115 , ( 9 ) 1385 - 1392 .

Xanthis I, Souilhol C, Serbanovic-Canic J, Roddie H, Kalli AC, Fragiadaki M, Wong R, Shah DR et al. ( 2019 ) . β1 integrin is a sensor of blood flow direction . Journal of Cell Science vol. 132 , ( 11 ) Article jcs229542 ,

Tardajos Ayllón B, Souilhol C, Oakley F, Evans P ( 2019 ) . BS14 c-Rel drives atherosclerosis at sites of disturbed blood flow by activating inflammatory and proliferative transcriptional programmes in endothelium . Basic Science . Conference: British Cardiovascular Society Annual Conference ‘Digital Health Revolution’ 3–5 June 2019A148.2 - A148 .

Roddie H, Fragiadaki M, Evans P ( 2019 ) . BS28 Endothelial STAT5A is enriched at atheroprone regions of the aorta and drives inflammation in response to low shear stress . Basic Science . Conference: British Cardiovascular Society Annual Conference ‘Digital Health Revolution’ 3–5 June 2019A158.1 - A158 .

Souilhol C, Canham L, Xueqi J, Evans P ( 2019 ) . BS3 Notch ligand JAG1 promotes endothelial-to-mesenchymal transition and atherosclerosis at regions of disturbed flow . Basic Science . Conference: British Cardiovascular Society Annual Conference ‘Digital Health Revolution’ 3–5 June 2019A142.1 - A142 .

Serbanovic-Canic J, Souilhol C, Evans PC ( 2019 ) . Shear stress makes its mark on the endothelial genome . Cardiovascular Research vol. 115 , ( 10 ) 1449 - 1451 .

Baeriswyl DC, Prionisti I, Peach T, Tsolkas G, Chooi KY, Vardakis J, Morel S, Diagbouga MR et al. ( 2019 ) . Disturbed flow induces a sustained, stochastic NF-κB activation which may support intracranial aneurysm growth in vivo . Scientific Reports vol. 9 , ( 1 ) Article 4738 ,

Mahmoud M, Souilhol C, Serbanovic-Canic J, Evans P ( 2019 ) . GATA4-Twist1 Signalling in Disturbed Flow-Induced Atherosclerosis . Cardiovascular Drugs and Therapy vol. 33 , ( 2 ) 231 - 237 .

Xanthis I, Souilhol C, Serbanovic-Canic J, Roddie H, Kalli AC, Fragiadaki M, Wong R, Shah DR et al. ( 2019 ) . β1 integrin is a sensor of blood flow direction .

Fragiadaki M, Evans PC ( 2018 ) . The Bernard and Joan Marshall Early Career Investigators and Distinguished Investigator Award 2018 . Cardiovascular Drugs and Therapy vol. 33 , ( 2 ) 203 - 205 .

Tuñón J, Badimón L, Bochaton-Piallat M-L, Cariou B, Daemen MJ, Egido J, Evans PC, Hoefer IE et al. ( 2018 ) . Identifying the anti-inflammatory response to lipid lowering therapy: a position paper from the working group on atherosclerosis and vascular biology of the European Society of Cardiology . Cardiovascular Research vol. 115 , ( 1 ) 10 - 19 .

Xing R, Moerman AM, Ridwan RY, Gaalen KV, Meester EJ, van der Steen AFW, Evans PC, Gijsen FJH et al. ( 2018 ) . The effect of the heart rate lowering drug Ivabradine on hemodynamics in atherosclerotic mice . Scientific Reports vol. 8 , ( 1 ) Article 14014 ,

Caporali A, Bäck M, Daemen MJ, Hoefer IE, Jones EA, Lutgens E, Matter CM, Bochaton-Piallat M-L et al. ( 2018 ) . Future directions for therapeutic strategies in post-ischaemic vascularization: a position paper from European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology . Cardiovascular Research vol. 114 , ( 11 ) 1411 - 1421 .

Alfaidi MA, Chamberlain J, Rothman A, Crossman D, Villa‐Uriol M, Hadoke P, Wu J, Schenkel T et al. ( 2018 ) . Dietary Docosahexaenoic Acid Reduces Oscillatory Wall Shear Stress, Atherosclerosis, and Hypertension, Most Likely Mediated via an IL‐1–Mediated Mechanism . Journal of the American Heart Association vol. 7 , ( 13 ) Article e008757 ,

Tuñón J, Bäck M, Badimón L, Bochaton-Piallat M-L, Cariou B, Daemen MJ, Egido J, Evans PC et al. ( 2018 ) . Interplay between hypercholesterolaemia and inflammation in atherosclerosis: Translating experimental targets into clinical practice . European Journal of Preventive Cardiology vol. 25 , ( 9 ) 948 - 955 .

Gomez I, Ward B, Souilhol C, Recarti C, Ariaans M, Johnston J, Burnett A, Mahmoud M et al. ( 2018 ) . Neutrophil microvesicles drive atherosclerosis by delivering<i>miR-155</i>to atheroprone endothelium .

Souilhol C, Evans PC ( 2018 ) . Notching Up Vascular Inflammation . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 38 , ( 4 ) 698 - 699 .

Gijsen FJH, Wentzel JJ, Heiden KVD, Evans PC ( 2018 ) . Biomechanics in vascular biology and cardiovascular disease . Thrombosis and Haemostasis vol. 115 , ( 03 ) 465 - 466 .

Souilhol C, Harmsen MC, Evans PC, Krenning G ( 2018 ) . Endothelial–mesenchymal transition in atherosclerosis . Cardiovascular Research vol. 114 , ( 4 ) 565 - 577 .

Feng S, Fragiadaki M, Souilhol C, Ridger V, Evans PC ( 2017 ) . Response by Feng et al to Letter Regarding Article, “Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites” . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 37 , ( 12 )

Ridger VC, Boulanger CM, Angelillo-Scherrer A, Badimon L, Blanc-Brude O, Bochaton-Piallat M-L, Boilard E, Buzas EI et al. ( 2017 ) . Microvesicles in vascular homeostasis and diseases . Thrombosis and Haemostasis vol. 117 , ( 07 ) 1296 - 1316 .

Le L, Duckles H, Schenkel T, Mahmoud M, Tremoleda J, Wylezinska-Arridge M, Ali M, Bowden N et al. ( 2017 ) . Heart rate reduction with ivabradine promotes shear stress-dependent anti-inflammatory mechanisms in arteries . Thrombosis and Haemostasis vol. 116 , ( 07 ) 181 - 190 .

Green JP, Souilhol C, Xanthis I, Martinez-Campesino L, Bowden NP, Evans PC, Wilson HL ( 2017 ) . Atheroprone flow activates inflammation via endothelial ATP-dependent P2X7-p38 signalling . Cardiovascular Research vol. 114 , ( 2 ) 324 - 335 .

Feng S, Bowden N, Fragiadaki M, Souilhol C, Hsiao S, Mahmoud M, Allen S, Pirri D et al. ( 2017 ) . Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 37 , ( 11 ) 2087 - 2101 .

Mahmoud MM, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J et al. ( 2017 ) . Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail . Scientific Reports vol. 7 , ( 1 ) Article 3375 ,

Mann P, Khamis RYJ, Haskard D, Ta M, Kojima C, Ammari T, Caga-Anan M, Nguyen BA et al. ( 2017 ) . 169 Developing capture assays to measure circulating crp/oxidised low density lipoprotein complexes in patients undergoing cardiopulmonary bypass and examining use of crp/oxidised low density lipoprotein complexes as a biomarker of atherosclerosis . Heart vol. 103 , ( Suppl 5 ) A119.2 - A119 .

Nguyen BAV, McDonald G, Fiorentino F, Reeves BC, Kwak J, Pyo S, Angelini GD, Anderson JR et al. ( 2017 ) . Consumption of Broccoli Sprouts Attenuates Intracellular P38 Map Kinase and Reactive Oxygen Species Pro-Inflammatory Activation in Human Leukocytes: A Randomised- Controlled Trial . Journal of Clinical Nutrition &amp; Dietetics vol. 03 , ( 04 )

Serbanovic-Canic J, de Luca A, Warboys C, Ferreira PF, Luong LA, Hsiao S, Gauci I, Mahmoud M et al. ( 2017 ) . Zebrafish Model for Functional Screening of Flow-Responsive Genes . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 37 , ( 1 ) 130 - 143 .

Nguyen B, Reeves B, Angelini G, Haskard D, Evans P ( 2016 ) . Reply . The Annals of Thoracic Surgery vol. 102 , ( 5 ) 1765 - 1766 .

Holloway PM, Gillespie S, Becker F, Vital SA, Nguyen V, Alexander JS, Evans PC, Gavins FNE ( 2016 ) . Sulforaphane induces neurovascular protection against a systemic inflammatory challenge via both Nrf2-dependent and independent pathways . Vascular Pharmacology vol. 85 , 29 - 38 .

Hsiao ST, Spencer T, Boldock L, Prosseda SD, Xanthis I, Tovar-Lopez FJ, Van Beusekom HMM, Khamis RY et al. ( 2016 ) . Endothelial repair in stented arteries is accelerated by inhibition of Rho-associated protein kinase . Cardiovascular Research vol. 112 , ( 3 ) 689 - 701 .

Bowden N, Bryan MT, Duckles H, Feng S, Hsiao S, Kim HR, Mahmoud M, Moers B et al. ( 2016 ) . Experimental Approaches to Study Endothelial Responses to Shear Stress . Antioxidants &amp; Redox Signaling vol. 25 , ( 7 ) 389 - 400 .

Halliday I, Lishchuk SV, Spencer TJ, Pontrelli G, Evans PC ( 2016 ) . Local membrane length conservation in two-dimensional vesicle simulation using a multicomponent lattice Boltzmann equation method . Physical Review E vol. 94 , ( 2 ) Article 023306 ,

Mahmoud MM, Kim HR, Xing R, Hsiao S, Mammoto A, Chen J, Serbanovic-Canic J, Feng S et al. ( 2016 ) . TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis . Circulation Research vol. 119 , ( 3 ) 450 - 462 .

Green J, Evans P, Wilson H ( 2016 ) . 191 Atheroprone Flow Alters ATP-Induced Calcium Signalling in the Endothelium . Heart vol. 102 , ( Suppl 6 ) A130.1 - A130 .

Bowden N, Feng S, Francis S, Evans P ( 2016 ) . 211 Non-Canonical NF-Κb Signalling Promotes Endothelial Proliferation in Response to Low Wall Shear Stress . Heart vol. 102 , ( Suppl 6 ) A140.1 - A140 .

Nguyen BAV, Fiorentino F, Reeves BC, Baig K, Athanasiou T, Anderson JR, Haskard DO, Angelini GD et al. ( 2016 ) . Mini Bypass and Proinflammatory Leukocyte Activation: A Randomized Controlled Trial . The Annals of Thoracic Surgery vol. 101 , ( 4 ) 1454 - 1463 .

Brown AJ, Teng Z, Evans PC, Gillard JH, Samady H, Bennett MR ( 2016 ) . Role of biomechanical forces in the natural history of coronary atherosclerosis . Nature Reviews Cardiology vol. 13 , ( 4 ) 210 - 220 .

Maguire R, Duckles H, Evans PC, Chico T ( 2016 ) . How does blood flow regulate vascular notch signalling? . Atherosclerosis vol. 244 , e8 - e8 .

Morris PD, Narracott A, von Tengg-Kobligk H, Silva Soto DA, Hsiao S, Lungu A, Evans P, Bressloff NW et al. ( 2015 ) . Computational fluid dynamics modelling in cardiovascular medicine . Heart vol. 102 , ( 1 ) 18 - 28 .

Di Marco LY, Venneri A, Farkas E, Evans PC, Marzo A, Frangi AF ( 2015 ) . Vascular dysfunction in the pathogenesis of Alzheimer's disease — A review of endothelium-mediated mechanisms and ensuing vicious circles . Neurobiology of Disease vol. 82 , 593 - 606 .

Green J, Wilson H, Evans P ( 2015 ) . 185 Shear Stress Dependent Regulation of p2x4 and p2x7 Receptors in the Endothelium . Heart vol. 101 , ( Suppl 4 ) A104.1 - A104 .

Alfaidi M, Schenkel T, Evans P, Chamberlain J, Francis S ( 2015 ) . 192 Dietary Docosahexaenoic Acid Reduced Experimental Atherosclerosis by Inducing Protective Haemodynamic Conditions . Heart vol. 101 , ( Suppl 4 ) A107.2 - A107 .

Mahmoud M, Kim R, Hsiao S, Xing R, Heiden KVD, Mammoto A, Chen J, Gauci I et al. ( 2015 ) . 204 Disturbed Flow Promotes Atherogenesis through the Activation of Endothelial-Mesenchymal Transition . Heart vol. 101 , ( Suppl 4 ) A112.2 - A113 .

Bryan M, Xanthis I, Hsiao S, Evans P ( 2015 ) . 206 Using Magnetic Tweezers to probe Mechanically-Induced Signalling in Endothelial Cells . Heart . vol. 101 , A113.2 - A114 .

Gomez I, Ward B, Evans P, Hellewell P, Ridger V ( 2015 ) . YIA2 Neutrophil Microvesicles Influence Atherogenesis and Contain Mirna . Heart vol. 101 , ( Suppl 4 ) A122 - A123 .

Hoefer IE, Steffens S, Ala-Korpela M, Bäck M, Badimon L, Bochaton-Piallat M-L, Boulanger CM, Caligiuri G et al. ( 2015 ) . Novel methodologies for biomarker discovery in atherosclerosis . European Heart Journal vol. 36 , ( 39 ) 2635 - 2642 .

Gomez I, Ward B, Evans P, Hellewell P, Ridger V ( 2015 ) . Abstract 558: Neutrophils-derived-microvesicle Could Play a Role in the Early Stage of Atherosclerosis . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 35 , ( suppl_1 )

Kidher E, Jarral OA, Harling L, Anderson JR, Chukwuemeka A, Ashrafian H, Evans PC, Athanasiou T ( 2015 ) . NR2 antibody is associated with quality of life in aortic valve replacement . Asian Cardiovascular and Thoracic Annals vol. 23 , ( 6 ) 690 - 700 .

Mylroie H, Dumont O, Bauer A, Thornton CC, Mackey J, Calay D, Hamdulay SS, Choo JR et al. ( 2015 ) . PKCε-CREB-Nrf2 signalling induces HO-1 in the vascular endothelium and enhances resistance to inflammation and apoptosis . Cardiovascular Research vol. 106 , ( 3 ) 509 - 519 .

Enesa K, Moll HP, Luong L, Ferran C, Evans PC ( 2015 ) . A20 suppresses vascular inflammation by recruiting proinflammatory signaling molecules to intracellular aggresomes . The FASEB Journal vol. 29 , ( 5 ) 1869 - 1878 .

Bowden N, Duckles H, Mahmoud M, Hsiao S, Francis SE, Evans PC ( 2014 ) . Disturbed flow induces expression of the negative NF-kappaB regulator Cezanne . Atherosclerosis vol. 237 , ( 2 ) e2 - e2 .

Gauci I, Mahmoud M, Duckles H, Feng S, Hsiao S, Evans PC ( 2014 ) . Disturbed flow influences endothelial activation by inducing homeobox transcription factors . Atherosclerosis vol. 237 , ( 2 ) e8 - e8 .

Mahmoud M, Hsiao S, Gauci I, Kim HR, Evans PC ( 2014 ) . GATA4 promotes endothelial cell turnover at regions of arteries exposed to disturbed flow . Atherosclerosis vol. 237 , ( 2 ) e2 - e3 .

Duckles H, Mahmoud M, Hsiao S, Gauci I, Bowden N, Luong L, Evans PC ( 2014 ) . Identification of a molecular switch controlling the induction of senescence or quiescence by flow . Atherosclerosis vol. 237 , ( 2 ) e7 - e7 .

Bryan MT, Duckles H, Feng S, Hsiao ST, Kim HR, Serbanovic-Canic J, Evans PC ( 2014 ) . Mechanoresponsive Networks Controlling Vascular Inflammation . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 34 , ( 10 ) 2199 - 2205 .

Kwak BR, Bäck M, Bochaton-Piallat M-L, Caligiuri G, Daemen MJAP, Davies PF, Hoefer IE, Holvoet P et al. ( 2014 ) . Biomechanical factors in atherosclerosis: mechanisms and clinical implications . European Heart Journal vol. 35 , ( 43 ) 3013 - 3020 .

Li J, Hou B, Tumova S, Muraki K, Bruns A, Ludlow MJ, Sedo A, Hyman AJ et al. ( 2014 ) . Piezo1 integration of vascular architecture with physiological force . Nature vol. 515 , ( 7526 ) 279 - 282 .

Cuhlmann S, Gsell W, Van der Heiden K, Habib J, Tremoleda JL, Khalil M, Turkheimer F, Meens MJ et al. ( 2014 ) . In Vivo Mapping of Vascular Inflammation Using the Translocator Protein Tracer ¹⁸F-FEDAA1106 . Molecular Imaging vol. 13 , ( 6 ) Article 7290.2014.00014 ,

Amini N, Boyle JJ, Moers B, Warboys CM, Malik TH, Zakkar M, Francis SE, Mason JC et al. ( 2014 ) . Requirement of JNK1 for endothelial cell injury in atherogenesis . Atherosclerosis vol. 235 , ( 2 ) 613 - 618 .

Nguyen B, Luong L, Naase H, Vives M, Jakaj G, Finch J, Boyle J, Mulholland JW et al. ( 2014 ) . Sulforaphane pretreatment prevents systemic inflammation and renal injury in response to cardiopulmonary bypass . The Journal of Thoracic and Cardiovascular Surgery vol. 148 , ( 2 ) 690 - 697.e3 .

Hsiao S, Tovar-Lopez FJ, Gunn J, Spencer T, Halliday I, Perrault C, Evans PC ( 2014 ) . 292Endothelial cell forward migration in a disturbed wall shear stress environment is promoted by ROCK inhibition . Cardiovascular Research vol. 103 , ( suppl 1 ) S53.3 - S53 .

Mahmoud M, Kim R, De Luca A, Gauci I, Hsiao S, Evans PC ( 2014 ) . P470Disturbed flow promotes endothelial cell injury via the induction of developmental genes . Cardiovascular Research . vol. 103 , S86.1 - S86 .

Kidher E, Harling L, Ashrafian H, Naase H, Francis DP, Evans P, Athanasiou T ( 2014 ) . Aortic stiffness as a marker of cardiac function and myocardial strain in patients undergoing aortic valve replacement . Journal of Cardiothoracic Surgery vol. 9 , ( 1 ) Article 102 ,

Nguyen BAV, Suleiman M-S, Anderson JR, Evans PC, Fiorentino F, Reeves BC, Angelini GD ( 2014 ) . Metabolic derangement and cardiac injury early after reperfusion following intermittent cross-clamp fibrillation in patients undergoing coronary artery bypass graft surgery using conventional or miniaturized cardiopulmonary bypass . Molecular and Cellular Biochemistry vol. 395 , ( 1-2 ) 167 - 175 .

Kidher E, Harling L, Sugden C, Ashrafian H, Casula R, Evans P, Nihoyannopoulos P, Athanasiou T ( 2014 ) . Aortic stiffness is an indicator of cognitive dysfunction before and after aortic valve replacement for aortic stenosis . Interactive CardioVascular and Thoracic Surgery vol. 19 , ( 4 ) 595 - 604 .

Mahmoud M, Kim R, de Luca A, Gauci I, Hsiao S, Evans P ( 2014 ) . 189 Disturbed Flow Promotes Endothelial Cell Injury Via the Induction of Developmental Genes . Heart . vol. 100 , A105.2 - A105 .

Gauci I, Luong L, Mahmoud M, Duckles H, Hsiao S, DeLuca A, Evans P ( 2014 ) . 192 The Induction of Homeobox Genes by Disturbed Flow Limits Inflammation at Atherosusceptible Sites . Heart . vol. 100 , A106.2 - A107 .

Hsiao S, Tovar F, Gunn J, Spencer T, Halliday I, Perrault C, Evans P ( 2014 ) . 219 Rock Inhibits Endothelial Migration in Disturbed flow Condition: A Potential Therapeutic Target in PCI . Heart vol. 100 , ( Suppl 3 ) A120.1 - A120 .

Luong L, Duckles H, Schenkel T, Arnold N, Gsell W, Lungu A, Spencer T, Hose R et al. ( 2014 ) . Abstract 258: A Pharmacological Approach to Promote Shear Stress-Dependent Anti-inflammatory Mechanisms in Arteries . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 34 , ( suppl_1 )

Mahmoud M, Kim R, de Luca A, Gauci I, Hsiao S, Evans PC ( 2014 ) . Abstract 266: Disturbed Flow Promotes Endothelial Cell Injury via the Induction of Developmental Genes . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 34 , ( suppl_1 )

Hsiao S, Tovar-Lopez F, Gunn J, Spencer T, Halliday I, Perrault C, Evans P ( 2014 ) . Abstract 521: Endothelial Cell Forward Migration in a Disturbed Wall Shear Stress Environment is Promoted by Rho-Kinase Inhibition . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 34 , ( suppl_1 )

Warboys CM, de Luca A, Amini N, Luong L, Duckles H, Hsiao S, White A, Biswas S et al. ( 2014 ) . Disturbed Flow Promotes Endothelial Senescence via a p53-Dependent Pathway . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 34 , ( 5 ) 985 - 995 .

Enesa K, Evans P ( 2014 ) . The Biology of A20-Like Molecules . Advances in Experimental Medicine and Biology , Springer New York

Bovens SM, Foin N, O'Clery N, Van Der Heiden K, Cuhlmann S, Carlsen H, Barahona M, Evans PC et al. ( 2013 ) . Shear stress and nitric oxide transport affect NFkB dynamics in endothelial cells . European Heart Journal vol. 34 , ( suppl 1 ) P582 - P582 .

Wells RE, Barry JD, Warrington SJ, Cuhlmann S, Evans P, Huber W, Strutt D, Zeidler MP ( 2013 ) . Control of tissue morphology by Fasciclin III-mediated intercellular adhesion . Development vol. 140 , ( 18 ) 3858 - 3868 .

De Luca A, Warboys CM, Amini N, Ferreira P, Gatehouse P, Firmin D, Mason J, Sherwin S et al. ( 2012 ) . Image-Based Computational Hemodynamics and Microarray Analysis of the Porcine Aortic Arch Reveals a Correlation Between Shear Stress and Endothelial Cell Apoptosis . ASME 2012 Summer Bioengineering Conference, Parts A and B . Conference: ASME 2012 Summer Bioengineering Conference from: 20/06/2012 to: 23/06/2012 , 923 - 924 .

Van der Heiden K, Groen HC, Evans PC, Speelman L, Gijsen F, de Jong M, van der Steen AFW, Wentzel JJ ( 2012 ) . Non-Invasive Molecular Imaging of Shear Stress-Induced Endothelial Activation and Atherosclerotic Plaque Vulnerability . ASME 2012 Summer Bioengineering Conference, Parts A and B . Conference: ASME 2012 Summer Bioengineering Conference from: 20/06/2012 to: 23/06/2012 , 91 - 92 .

Luong LA, Fragiadaki M, Smith J, Boyle J, Lutz J, Dean JLE, Harten S, Ashcroft M et al. ( 2013 ) . Cezanne Regulates Inflammatory Responses to Hypoxia in Endothelial Cells by Targeting TRAF6 for Deubiquitination . Circulation Research vol. 112 , ( 12 ) 1583 - 1591 .

Evans PC, Kwak BR ( 2013 ) . Biomechanical factors in cardiovascular disease . Cardiovascular Research vol. 99 , ( 2 ) 229 - 231 .

Gray C, Bratt D, Lees J, daCosta M, Plant K, Watson OJ, Solaymani-Kohal S, Tazzyman S et al. ( 2013 ) . Loss of Function of Parathyroid Hormone Receptor 1 Induces Notch-Dependent Aortic Defects During Zebrafish Vascular Development . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 33 , ( 6 ) 1257 - 1263 .

De Luca A, Warboys C, Amini N, Ferreira P, Firmin D, Mason J, Sherwin S, Evans P ( 2013 ) . 170 TRANSCRIPTOME PROFILING IN PORCINE ARTERIES TO IDENTIFY NOVEL SHEAR-RESPONSIVE REGULATORS OF ENDOTHELIAL CELL FATE . Heart vol. 99 , ( suppl 2 ) A98.2 - A99 .

Serbanovic-Canic J, de Luca A, Warboys C, Chico T, Evans P ( 2013 ) . YIA4: IDENTIFICATION OF NOVEL SHEAR STRESS-RESPONSIVE REGULATORS OF ENDOTHELIAL CELL DYSFUNCTION USING THE ZEBRAFISH MODEL . Heart vol. 99 , ( suppl 2 ) A6.1 - A6 .

Van der Heiden K, Gijsen FJH, Narracott A, Hsiao S, Halliday I, Gunn J, Wentzel JJ, Evans PC ( 2013 ) . The effects of stenting on shear stress: relevance to endothelial injury and repair . Cardiovascular Research vol. 99 , ( 2 ) 269 - 275 .

Haskard DO, Boyle JJ, Evans PC, Mason JC, Randi AM ( 2013 ) . Cytoprotective Signaling and Gene Expression in Endothelial Cells and Macrophages—Lessons for Atherosclerosis . Microcirculation vol. 20 , ( 3 ) 203 - 216 .

Bovens SM, Foin N, O'Clery N, Van der Heiden K, Cuhlmann S, Carlsen H, Barahona M, Evans PC et al. ( 2013 ) . Shear stress and nitric oxide transport affect NFkB dynamics in endothelial cells . EUROPEAN HEART JOURNAL . vol. 34 , 110 - 110 .

Warboys CM, de Luca A, Amini N, Evans PC ( 2012 ) . The influence of flow on vascular endothelial cell senescence . Atherosclerosis . vol. 225 , e6 - e6 .

Golubnitschaja O, Costigliola V ( 2012 ) . General Report &amp; Recommendations in Predictive, Preventive and Personalised Medicine 2012: White Paper of the European Association for Predictive, Preventive and Personalised Medicine . EPMA Journal vol. 3 , ( 1 ) Article 14 ,

Nayak A, König CS, Kishore U, Evans PC ( 2012 ) . Regulation of Endothelial Activation and Vascular Inflammation by Shear Stress . Micro and Nano Flow Systems for Bioanalysis , Springer New York

Dumont O, Mylroie H, Bauer A, Calay D, Sperone A, Thornton C, Hamdulay SS, Ali N et al. ( 2012 ) . Protein kinase Cϵ activity induces anti-inflammatory and anti-apoptotic genes via an ERK1/2- and NF-κB-dependent pathway to enhance vascular protection . Biochemical Journal vol. 447 , ( 2 ) 193 - 204 .

Pfenniger A, Wong C, Sutter E, Cuhlmann S, Dunoyer-Geindre S, Mach F, Horrevoets AJ, Evans PC et al. ( 2012 ) . Shear stress modulates the expression of the atheroprotective protein Cx37 in endothelial cells . Journal of Molecular and Cellular Cardiology vol. 53 , ( 2 ) 299 - 309 .

Boyle JJ, Christou I, Iqbal MB, Nguyen AT, Leung VWY, Evans PC, Liu Y, Johns M et al. ( 2012 ) . Solid-Phase Immunoglobulins IgG and IgM Activate Macrophages with Solid-Phase IgM Acting via a Novel Scavenger Receptor A Pathway . The American Journal of Pathology vol. 181 , ( 1 ) 347 - 361 .

Kuhlmann MT, Cuhlmann S, Hoppe I, Krams R, Evans PC, Strijkers GJ, Nicolay K, Hermann S et al. ( 2012 ) . Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice . Journal of Visualized Experiments ( 59 )

Boyle JJ, Johns M, Lo J, Chiodini A, Ambrose N, Evans PC, Mason JC, Haskard DO ( 2011 ) . Heme Induces Heme Oxygenase 1 via Nrf2 . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 31 , ( 11 ) 2685 - 2691 .

Luong LA, Evans PC ( 2011 ) . Targeting Inhibitor of Apoptosis Proteins to Block Vascular Inflammation . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 31 , ( 10 ) 2165 - 2166 .

Halliday I, Atherton M, Care CM, Collins MW, Evans D, Evans PC, Hose DR, Khir AW et al. ( 2011 ) . Multi-scale interaction of particulate flow and the artery wall . MED ENG PHYS vol. 33 , ( 7 ) 840 - 848 .

Harling L, Warren OJ, Martin A, Kemp PR, Evans PC, Darzi A, Athanasiou T ( 2011 ) . Do Miniaturized Extracorporeal Circuits Confer Significant Clinical Benefit Without Compromising Safety? A Meta-Analysis of Randomized Controlled Trials . ASAIO Journal vol. 57 , ( 3 ) 141 - 151 .

Jevon M, Ansari TI, Finch J, Zakkar M, Evans PC, Shurey S, Sibbons PD, Hornick P et al. ( 2011 ) . Smooth muscle cells in porcine vein graft intimal hyperplasia are derived from the local vessel wall . Cardiovascular Pathology vol. 20 , ( 3 ) e91 - e94 .

Cuhlmann S, Van der Heiden K, Saliba D, Tremoleda JL, Khalil M, Zakkar M, Chaudhury H, Luong LA et al. ( 2011 ) . Disturbed Blood Flow Induces RelA Expression via c-Jun N-Terminal Kinase 1 . Circulation Research vol. 108 , ( 8 ) 950 - 959 .

Warboys CM, Amini N, Luca AD, Evans PC ( 2011 ) . The role of blood flow in determining the sites of atherosclerotic plaques . F1000 Medicine Reports vol. 3 ,

Evans PC ( 2011 ) . The influence of sulforaphane on vascular health and its relevance to nutritional approaches to prevent cardiovascular disease . EPMA Journal vol. 2 , ( 1 ) 9 - 14 .

Zakkar M, Luong LA, Chaudhury H, Ruud O, Punjabi PP, Anderson JR, Mullholand JW, Clements AT et al. ( 2011 ) . Dexamethasone Arterializes Venous Endothelial Cells by Inducing Mitogen-Activated Protein Kinase Phosphatase-1 . Circulation vol. 123 , ( 5 ) 524 - 532 .

Warboys CM, Amini N, Luca AD, Evans PC ( 2011 ) . When stress is good . Scientist vol. 25 , ( 2 )

Gsell W, Cuhlmann S, Van der Heiden K, Tremoleda JL, Khalil M, Clark J, Bird J, Jones H et al. ( 2011 ) . <SUP>18</SUP>FEDAA is a more specific probe than <SUP>18</SUP>FDG for imaging vascular inflammation . EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING vol. 38 , S210 - S210 .

Pfenniger A, Sutter E, Cuhlmann S, Evans PC, Krams R, Kwak BR ( 2011 ) . Endothelial Cx37 expression is regulated by the shear stress responsive transcription factor KLF2 . EUROPEAN HEART JOURNAL . vol. 32 , 937 - 937 .

Sperone A, Dryden NH, Birdsey GM, Madden L, Johns M, Evans PC, Mason JC, Haskard DO et al. ( 2011 ) . The Transcription Factor Erg Inhibits Vascular Inflammation by Repressing NF-κB Activation and Proinflammatory Gene Expression in Endothelial Cells . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 31 , ( 1 ) 142 - 150 .

Sperone A, Dryden N, Birdsey GM, Madden LE, Evans P, Mason JC, Boyle J, Paleolog E et al. ( 2010 ) . The transcription factor Erg represses ICAM-1 expression and vascular inflammation . ATHEROSCLEROSIS . vol. 213 , E17 - E17 .

Vossenkamper A, Marches O, Fairclough PD, Warnes G, Stagg AJ, Lindsay JO, Evans PC, Luong L et al. ( 2010 ) . Inhibition of NF-kappa B Signaling in Human Dendritic Cells by the Enteropathogenic Escherichia coli Effector Protein NleE . J IMMUNOL vol. 185 , ( 7 ) 4118 - 4127 .

Cuhlmann S, van der Heiden K, Zakkar M, Chaudhury H, Luong LA, Mason J, Haskard DO, Carlsen H et al. ( 2010 ) . YIA4 C Jun N-terminal kinase promotes endothelial activation at atherosclerosis-susceptible sites by enhancing expression of NF- B transcription factors . Heart vol. 96 , ( 17 ) e10 - e10 .

Hamdulay SS, Wang B, Birdsey GM, Ali F, Dumont O, Evans PC, Haskard DO, Wheeler-Jones CP et al. ( 2010 ) . Celecoxib activates PI-3K/Akt and mitochondrial redox signaling to enhance heme oxygenase-1-mediated anti-inflammatory activity in vascular endothelium . Free Radical Biology and Medicine vol. 48 , ( 8 ) 1013 - 1023 .

Chaudhury H, Zakkar M, Boyle J, Cuhlmann S, van der Heiden K, Luong LA, Davis J, Platt A et al. ( 2010 ) . c-Jun N-Terminal Kinase Primes Endothelial Cells at Atheroprone Sites for Apoptosis . ARTERIOSCL THROM VAS vol. 30 , ( 3 ) 546 - U393 .

van der Heiden K, Cuhlmann S, Luong LA, Zakkar M, Evans PC ( 2010 ) . Role of nuclear factor κB in cardiovascular health and disease . Clinical Science vol. 118 , ( 10 ) 593 - 605 .

Amirak E, Zakkar M, Evans PC, Kemp PR ( 2010 ) . Perfusion of veins at arterial pressure increases the expression of KLF5 and cell cycle genes in smooth muscle cells . Biochemical and Biophysical Research Communications vol. 391 , ( 1 ) 818 - 823 .

Pfenniger A, Galan K, Wong C, Cuhlmann S, Evans PC, Krams R, Kwak BR ( 2010 ) . Shear Stress Modulates the Expression of the Vasoprotective Protein Cx37 in Endothelial Cells . CIRCULATION . vol. 122 ,

Krams R, Cuhlmann S, Foin N, Evans P ( 2010 ) . Shear stress, inflammation and Atherosclerosis . Artery Research vol. 4 , ( 2 ) 41 - 41 .

Zakkar M, Van der Heiden K, Luong LA, Chaudhury H, Cuhlmann S, Hamdulay SS, Krams R, Edirisinghe I et al. ( 2009 ) . Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a Proinflammatory State . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 29 , ( 11 ) 1851 - 1857 .

Evans P ( 2008 ) . Reservoir Souring Modelling, Prediction and Mitigation . Volume 5: Materials Technology; CFD and VIV . Conference: ASME 2008 27th International Conference on Offshore Mechanics and Arctic Engineering from: 15/06/2008 to: 20/06/2008 , 67 - 73 .

Ali F, Zakkar M, Karu K, Lidington EA, Hamdulay SS, Boyle JJ, Zloh M, Bauer A et al. ( 2009 ) . Induction of the Cytoprotective Enzyme Heme Oxygenase-1 by Statins Is Enhanced in Vascular Endothelium Exposed to Laminar Shear Stress and Impaired by Disturbed Flow . Journal of Biological Chemistry vol. 284 , ( 28 ) 18882 - 18892 .

Evans PC ( 2009 ) . Nur77 . Circulation Research vol. 104 , ( 6 ) 707 - 709 .

Zakkar M, van der Heiden K, Chaudhury H, Krams R, Haskard DO, Mason JC, Evans PC ( 2009 ) . ACTIVATION OF NF-E2 RELATED FACTOR-2 (NRF2) PROTECTS ARTERIES FROM EXHIBITING A PRO-INFLAMMATORY STATE . HEART . vol. 95 ,

Chaudhury HA, Zakkar M, Boyle J, Dennis J, van der Heiden K, Luong L, Cuhlmann S, Mason JM et al. ( 2009 ) . ENDOTHELIAL CELLS AT ATHEROSUSCEPTIBLE SITES EXPRESS ACTIVATED C-JUN N-TERMINAL KINASE WHICH INDUCES PRO-APOPTOTIC MOLECULES . HEART . vol. 95 ,

Cuhlmann S, van der Heiden K, Zakkar M, Chaudhury H, Luong LA, Mason JM, Haskard DO, Krams R et al. ( 2009 ) . HIGH SHEAR STRESS SUPPRESSES THE EXPRESSION AND ACTIVITY OF NF-KAPPAB TRANSCRIPTION FACTORS IN ARTERIAL ENDOTHELIUM . HEART . vol. 95 ,

Foin N, Plata-Garcia A, Cuhlmann S, Evans PC, Caro CG, Krams R ( 2009 ) . SHEAR STRESS AND NITRIC OXIDE TRANSPORT AFFECT NF-KB DYNAMICS IN ENDOTHELIAL CELLS . HEART . vol. 95 ,

Foin N, Plata-Garcia A, Qin Q, Cuhlmann S, Evans PC, Caro CG, Krams R ( 2009 ) . Shear Stress and Nitric Oxide Transport Affect NF-κB Dynamics In Endothelial Cells . ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY . vol. 29 , E78 - E78 .

Evans PC ( 2008 ) . Effects of shear stress on endothelial activation and vascular inflammation . Biomedicine &amp; Pharmacotherapy vol. 62 , ( 8 ) 503 - 504 .

Ridger V, Krams R, Carpi A, Evans PC ( 2008 ) . Hemodynamic parameters regulating vascular inflammation and atherosclerosis: A brief update . Biomedicine &amp; Pharmacotherapy vol. 62 , ( 8 ) 536 - 540 .

Zakkar M, Chaudhury H, Sandvik G, Enesa K, Luong LA, Cuhlmann S, Mason JC, Krams R et al. ( 2008 ) . Increased Endothelial Mitogen-Activated Protein Kinase Phosphatase-1 Expression Suppresses Proinflammatory Activation at Sites That Are Resistant to Atherosclerosis . Circulation Research vol. 103 , ( 7 ) 726 - 732 .

Lutz J, Luong LA, Strobl M, Deng M, Huang H, Anton M, Zakkar M, Enesa K et al. ( 2008 ) . The A20 gene protects kidneys from ischaemia/reperfusion injury by suppressing pro-inflammatory activation . Journal of Molecular Medicine vol. 86 , ( 12 ) 1329 - 1339 .

Zakkar M, Chaudhury H, Krams R, Mason JC, Clark AR, Haskard DO, Evans PC ( 2008 ) . MAP KINASE PHOSPHATASE-1 SUPPRESSES ENDOTHELIAL ACTIVATION IN REGIONS OF THE ARTERIAL TREE THAT ARE RESISTANT TO ATHEROSCLEROSIS . Atherosclerosis . vol. 199 , 465 - 465 .

Enesa K, Ito K, Luong LA, Thorbjornsen I, Phua C, To Y, Dean J, Haskard DO et al. ( 2008 ) . Hydrogen Peroxide Prolongs Nuclear Localization of NF-κB in Activated Cells by Suppressing Negative Regulatory Mechanisms . Journal of Biological Chemistry vol. 283 , ( 27 ) 18582 - 18590 .

Birks EJ, Latif N, Enesa K, Folkvang T, Luong LA, Sarathchandra P, Khan M, Ovaa H et al. ( 2008 ) . Elevated p53 expression is associated with dysregulation of the ubiquitin-proteasome system in dilated cardiomyopathy . Cardiovascular Research vol. 79 , ( 3 ) 472 - 480 .

Kinderlerer AR, Ali F, Johns M, Lidington EA, Leung V, Boyle JJ, Hamdulay SS, Evans PC et al. ( 2008 ) . KLF2-dependent, Shear Stress-induced Expression of CD59 . Journal of Biological Chemistry . vol. 283 , 14636 - 14644 .

Mason JC, Kinderlerer A, Ali F, Johns M, Leung V, Boyle J, Evans P, Haskard DO ( 2008 ) . KLF‐2‐dependent, shear stress‐induced expression of CD59: a novel cytoprotective mechanism against complement‐mediated injury in the vasculature . The FASEB Journal vol. 22 , ( S1 )

Enesa K, Zakkar M, Chaudhury H, Luong LA, Rawlinson L, Mason JC, Haskard DO, Dean JLE et al. ( 2008 ) . NF-κB Suppression by the Deubiquitinating Enzyme Cezanne . Journal of Biological Chemistry vol. 283 , ( 11 ) 7036 - 7045 .

Foin N, Evans P, Krams R ( 2008 ) . Atherosclerosis: cell biology and lipoproteins - new developments in imaging of inflammation of the vulnerable plaque . CURR OPIN LIPIDOL vol. 19 , ( 1 ) 98 - 100 .

Zakkar M, Chaudhury H, Punjabi PP, Haskard DO, Evans PC ( 2008 ) . Acute high shear stress activates venous but not arterial endothelial cells by signalling through the p38 MAP kinase pathway . HEART . vol. 94 ,

Helderman F, Segers D, de Crom R, Hierck BP, Poelmann RE, Evans PC, Krams R ( 2007 ) . Effect of shear stress on vascular inflammation and plaque development . Current Opinion in Lipidology vol. 18 , ( 5 ) 527 - 533 .

Evans KEAPC ( 2007 ) . Chains of command: Ubiquitin in proinflammatory signalling . The Biochemist vol. 29 , ( 4 ) 24 - 27 .

Partridge J, Carlsen H, Enesa K, Chaudhury H, Zakkar M, Luong L, Kinderlerer A, Johns M et al. ( 2007 ) . Laminar shear stress acts as a switch to regulate divergent functions of NF‐κB in endothelial cells . The FASEB Journal vol. 21 , ( 13 ) 3553 - 3561 .

Adcock I, Evans PC ( 2007 ) . Resolution of Inflammatory Responses: a brief introduction . Biochemical Society Transactions . vol. 35 , 261 - 262 .

Partridge J, Enesa K, Kinderlerer A, Johns M, Mason JC, Haskard DO, Evans PC ( 2007 ) . Shear stress modulates endothelial responses to TNFα by suppressing proinflammatory transcripts and enhancing cytoprotective transcripts . HEART . vol. 93 ,

Evans P, Dunsmore B ( 2006 ) . Reservoir simulation of sulfate-reducing bacteria activity in the deep sub-surface . Nace International Corrosion Conference Series . 066641 - 0666417 .

Marques C, Guo W, Pereira P, Taylor A, Patterson C, Evans PC, Shang F ( 2006 ) . The triage of damaged proteins: degradation by the ubiquitin‐proteasome pathway or repair by molecular chaperones . The FASEB Journal vol. 20 , ( 6 ) 741 - 743 .

Evans PC ( 2005 ) . Regulation of pro-inflammatory signalling networks by ubiquitin: identification of novel targets for anti-inflammatory drugs . Expert Reviews in Molecular Medicine vol. 7 , ( 12 ) 1 - 19 .

Goodman RS, Ewing J, Evans PC, Craig J, Poulton K, Dyer PA, Marcus RE, Taylor CJ ( 2005 ) . Donor CD31 genotype and its association with acute graft-versus-host disease in HLA identical sibling stem cell transplantation . Bone Marrow Transplantation vol. 36 , ( 2 ) 151 - 156 .

EVANS PC, OVAA H, HAMON M, KILSHAW PJ, HAMM S, BAUER S, PLOEGH HL, SMITH TS ( 2004 ) . Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity . Biochemical Journal vol. 378 , ( 3 ) 727 - 734 .

Evans PC, Smith TS, Lai M-J, Williams MG, Burke DF, Heyninck K, Kreike MM, Beyaert R et al. ( 2003 ) . A Novel Type of Deubiquitinating Enzyme . Journal of Biological Chemistry vol. 278 , ( 25 ) 23180 - 23186 .

EVANS PC, TAYLOR ER, COADWELL J, HEYNINCK K, BEYAERT R, KILSHAW PJ ( 2001 ) . Isolation and characterization of two novel A20-like proteins . Biochemical Journal vol. 357 , ( 3 ) 617 - 617 .

Corps E, Carter C, Karecla P, Ahrens T, Evans P, Kilshaw P ( 2001 ) . Recognition of E-cadherin by Integrin αEβ7 . Journal of Biological Chemistry vol. 276 , ( 33 ) 30862 - 30870 .

EVANS PC, TAYLOR ER, COADWELL J, HEYNINCK K, BEYAERT R, KILSHAW PJ ( 2001 ) . Isolation and characterization of two novel A20-like proteins . Biochemical Journal vol. 357 , ( 3 ) 617 - 623 .

Evans PC, Smith S, Hirschfield G, Rigopoulou E, Wreghitt TG, Wight DGD, Taylor CJ, Alexander GJM ( 2001 ) . Recipient HLA-DR3, tumour necrosis factor-α promoter allele-2 (tumour necrosis factor-2) and cytomegalovirus infection are inter-related risk factors for chronic rejection of liver grafts . Journal of Hepatology vol. 34 , ( 5 ) 711 - 715 .

Evans PC, Taylor ER, Kilshaw PJ ( 2001 ) . SIGNALING THROUGH CD31 PROTECTS ENDOTHELIAL CELLS FROM APOPTOSIS . Transplantation vol. 71 , ( 3 ) 457 - 460 .

Buckley CD ( 2001 ) . Signaling Through CD31 Protects Endothelial Cells from Apoptosis. Transplantation 2001; 71: 457 . Transplantation vol. 71 , ( 3 ) 343 - 344 .

Evans PC, Kilshaw PJ ( 2000 ) . INTERLEUKIN-13 PROTECTS ENDOTHELIAL CELLS FROM APOPTOSIS AND ACTIVATION . Transplantation vol. 70 , ( 6 ) 928 - 934 .

Lambert NC, Evans PC, Hashizumi TL, Maloney S, Gooley T, Furst DE, Nelson JL ( 2000 ) . Cutting Edge: Persistent Fetal Microchimerism in T Lymphocytes Is Associated with HLA-DQA1*0501: Implications in Autoimmunity . The Journal of Immunology vol. 164 , ( 11 ) 5545 - 5548 .

Evans PC, Soin A, Wreghitt TG, Taylor CJ, Wight DGD, Alexander GJM ( 2000 ) . AN ASSOCIATION BETWEEN CYTOMEGALOVIRUS INFECTION AND CHRONIC REJECTION AFTER LIVER TRANSPLANTATION . Transplantation vol. 69 , ( 1 ) 30 - 30 .

EVANS PC, GRAY JJ, WREGHITT TG, MARCUS RE, ALEXANDER GJM ( 1999 ) . Comparison of three PCR techniques for detecting cytomegalovirus (CMV) DNA in serum, detection of early antigen fluorescent foci and culture for the diagnosis of CMV infection . Journal of Medical Microbiology vol. 48 , ( 11 ) 1029 - 1035 .

Evans PC, Coleman N, Wreghitt TG, Wight DGD, Alexander GJM ( 1999 ) . Cytomegalovirus infection of bile duct epithelial cells, hepatic artery and portal venous endothelium in relation to chronic rejection of liver grafts . Journal of Hepatology vol. 31 , ( 5 ) 913 - 920 .

Nasu K, Whyte A, Green SJ, Evans PC, Kilshaw PJ ( 1999 ) . ??-GALACTOSYL-MEDIATED ACTIVATION OF PORCINE ENDOTHELIAL CELLS . Transplantation vol. 68 , ( 6 ) 861 - 867 .

Maloney S, Smith A, Furst DE, Myerson D, Rupert K, Evans PC, Nelson JL ( 1999 ) . Microchimerism of maternal origin persists into adult life . Journal of Clinical Investigation vol. 104 , ( 1 ) 41 - 47 .

Evans PC, Lambert N, Maloney S, Furst DE, Moore JM, Nelson JL ( 1999 ) . Long-Term Fetal Microchimerism in Peripheral Blood Mononuclear Cell Subsets in Healthy Women and Women With Scleroderma . Blood vol. 93 , ( 6 ) 2033 - 2037 .

Evans PC, Soin A, Wreghitt TG, Alexander GJ ( 1998 ) . Qualitative and semiquantitative polymerase chain reaction testing for cytomegalovirus DNA in serum allows prediction of CMV related disease in liver transplant recipients . Journal of Clinical Pathology vol. 51 , ( 12 ) 914 - 921 .

Evans PC, Gray J, Wreghitt TG, Alexander GJM ( 1998 ) . Optimisation of the polymerase chain reaction and dot-blot hybridisation for detecting cytomegalovirus DNA in urine: comparison with detection of early antigen fluorescent foci and culture . Journal of Virological Methods vol. 73 , ( 1 ) 41 - 52 .

Nelson JL, Furst DE, Maloney S, Gooley T, Evans PC, Smith A, Bean MA, Ober C et al. ( 1998 ) . Microchimerism and HLA-compatible relationships of pregnancy in scleroderma . The Lancet vol. 351 , ( 9102 ) 559 - 562 .