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  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: DR Gabor Czibik

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Korbonits M, Wang X, Barry S, Suleyman O, Stefano DT, Uddin N, Hall CL, Laura P et al. ( 2025 ) . OR25-07 A Novel and Severe Multisystem Metabolic Disease due to Homozygous AIP Variants . Journal of the Endocrine Society vol. 9 , ( Supplement_1 )
Júnior RFR, Sawaki D, Chan LF, Czibik G ( 2025 ) . Editorial: Endocrine insights into heart disease . Frontiers in Endocrinology vol. 16 ,
Littlewood K, Gegic J, Hickman M, Henson RCJ, Bishop JR, Kershaw T, Diamond P, Slabaugh G et al. ( 2025 ) . Metabolic dysfunction over a life course key to healthy ageing inequality . Aging Clinical and Experimental Research vol. 37 , ( 1 )
Perna L, Salsbury G, Dushti M, Smith CJ, Morales V, Bianchi K, Czibik G, Chapple JP ( 2024 ) . Altered Cellular Metabolism Is a Consequence of Loss of the Ataxia-Linked Protein Sacsin . International Journal of Molecular Sciences vol. 25 , ( 24 )
Naushad S, Gaucher J, Mezdari Z, Détrait M, Belaidi E, Zhang Y, Vial G, Bouyon S et al. ( 2024 ) . Chronic intermittent hypoxia triggers cardiac fibrosis: Role of epididymal white adipose tissue senescent remodeling? . Acta Physiologica vol. 240 , ( 11 )
Derumeaux G, Sawaki D ( 2024 ) . Trajectories in Cardiac Aging: Journey to the Crossroads of Inflammation and Metabolism . Circulation vol. 149 , ( 25 ) 1935 - 1937 .
Sanpawithayakul K, Czibik G, Korbonits M ( 2023 ) . Live Fast, Die Young? . The Journal of Clinical Endocrinology & Metabolism vol. 109 , ( 1 ) e426 - e427 .
Sawaki D, Zhang Y, Mohamadi A, Pini M, Mezdari Z, Lipskaia L, Naushad S, Lamendour L et al. ( 2023 ) . Osteopontin promotes age-related adipose tissue remodeling through senescence-associated macrophage dysfunction . JCI Insight vol. 8 , ( 8 )
Lezoualc’h F, Badimon L, Baker H, Bernard M, Czibik G, de Boer RA, Kergoat M, Kowala M et al. ( 2022 ) . Diabetic cardiomyopathy: the need for adjusting experimental models to meet clinical reality . Cardiovascular Research vol. 119 , ( 5 ) 1130 - 1145 .
Czibik G, d’Humières T, Derumeaux G ( 2021 ) . When does too much energy become a danger to the heart? . European Heart Journal vol. 43 , ( 9 ) 878 - 880 .
Pini M, Czibik G, Sawaki D, Mezdari Z, Braud L, Delmont T, Mercedes R, Martel C et al. ( 2021 ) . Adipose tissue senescence is mediated by increased ATP content after a short‐term high‐fat diet exposure . Aging Cell vol. 20 , ( 8 )
Czibik G, Mezdari Z, Altintas DM, Bréhat J, Pini M, d’Humières T, Delmont T, Radu C et al. ( 2021 ) . Dysregulated Phenylalanine Catabolism Plays a Key Role in the Trajectory of Cardiac Aging . Circulation vol. 144 , ( 7 ) 559 - 574 .
( 2019 ) . The antioxidant N-acetylcysteine protects from lung emphysema but induces lung adenocarcinoma in mice . JCI Insight vol. 4 , ( 19 )
( 2019 ) . Response by Sawaki et al to Letter Regarding Article, “Visceral Adipose Tissue Drives Cardiac Aging Through Modulation of Fibroblast Senescence by Osteopontin Production” . Circulation vol. 139 , ( 6 ) 845 - 846 .
Mougenot N, Mika D, Czibik G, Marcos E, Abid S, Houssaini A, Vallin B, Guellich A et al. ( 2019 ) . Cardiac adenylyl cyclase overexpression precipitates and aggravates age-related myocardial dysfunction . Cardiovascular Research vol. 115 , ( 12 ) 1778 - 1790 .
( 2018 ) . Carbon monoxide–induced metabolic switch in adipocytes improves insulin resistance in obese mice . JCI Insight vol. 3 , ( 22 )
Sawaki D, Czibik G, Pini M, Ternacle J, Suffee N, Mercedes R, Marcelin G, Surenaud M et al. ( 2018 ) . Visceral Adipose Tissue Drives Cardiac Aging Through Modulation of Fibroblast Senescence by Osteopontin Production . Circulation vol. 138 , ( 8 ) 809 - 822 .
Yavari A, Bellahcene M, Bucchi A, Sirenko S, Pinter K, Herring N, Jung JJ, Tarasov KV et al. ( 2017 ) . Mammalian γ2 AMPK regulates intrinsic heart rate . Nature Communications vol. 8 , ( 1 )
Ernande L, Audureau E, Jellis CL, Bergerot C, Henegar C, Sawaki D, Volpi C, Canoui-Poitrine F et al. ( 2017 ) . Clinical Implications of Echocardiographic Phenotypes of Patients With Diabetes Mellitus . Journal of the American College of Cardiology vol. 70 , ( 14 ) 1704 - 1716 .
( 2017 ) . Connective tissue growth factor and bone morphogenetic protein 2 are induced following myocardial ischemia in mice and humans . Scandinavian Journal of Clinical and Laboratory Investigation vol. 77 , ( 5 ) 321 - 331 .
Ternacle J, Wan F, Sawaki D, Surenaud M, Pini M, Mercedes R, Ernande L, Adnot S ( 2017 ) . Short-term high-fat diet compromises myocardial function: a radial strain rate imaging study . European Heart Journal - Cardiovascular Imaging vol. 18 , ( 11 ) 1283 - 1291 .
( 2016 ) . Resistance of dynamin-related protein 1 oligomers to disassembly impairs mitophagy, resulting in myocardial inflammation and heart failure . Journal of Biological Chemistry vol. 291 , ( 49 )
( 2016 ) . Extracellular Calpain/Calpastatin Balance Is Involved in the Progression of Pulmonary Hypertension . American Journal of Respiratory Cell and Molecular Biology vol. 55 , ( 3 ) 337 - 351 .
( 2016 ) . Selective Tuberous Sclerosis Complex 1 Gene Deletion in Smooth Muscle Activates Mammalian Target of Rapamycin Signaling and Induces Pulmonary Hypertension . American Journal of Respiratory Cell and Molecular Biology vol. 55 , ( 3 ) 352 - 367 .
( 2016 ) . Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity . Proceedings of the National Academy of Sciences of the United States of America vol. 113 , ( 26 ) e3706 - e3715 .
Yavari A, Stocker CJ, Ghaffari S, Wargent ET, Steeples V, Pinter K, Bellahcene M, Woods A et al. ( 2016 ) . Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function . Cell Metabolism vol. 23 , ( 5 ) 821 - 836 .
( 2015 ) . Calpastatin overexpression impairs postinfarct scar healing in mice by compromising reparative immune cell recruitment and activation . AJP Heart and Circulatory Physiology vol. 309 , ( 11 ) h1883 - h1893 .
( 2014 ) . Subunit composition of AMPK trimers present in the cytokinetic apparatus: Implications for drug target identification . Cell Cycle vol. 11 , ( 5 ) 917 - 921 .
( 2014 ) . Heme oxygenase-1: an emerging therapeutic target to curb cardiac pathology . Basic Research in Cardiology vol. 109 , ( 6 )
( 2014 ) . Citric Acid Cycle Intermediates in Cardioprotection . Circulation Genomic and Precision Medicine vol. 7 , ( 5 ) 711 - 719 .
( 2014 ) . Expression of bone morphogenetic protein 4 and its receptors in the remodeling heart . Life Sciences vol. 97 , ( 2 ) 145 - 154 .
( 2012 ) . Aquaporin-1 in cardiac endothelial cells is downregulated in ischemia, hypoxia and cardioplegia . Journal of Molecular and Cellular Cardiology vol. 56 , 22 - 33 .
( 2012 ) . Embryonic expression of AMPK γ subunits and the identification of a novel γ2 transcript variant in adult heart . Journal of Molecular and Cellular Cardiology vol. 53 , ( 3 ) 342 - 349 .
Ashrafian H, Czibik G, Bellahcene M, Aksentijević D, Smith AC, Mitchell SJ, Dodd MS, Kirwan J et al. ( 2012 ) . Fumarate Is Cardioprotective via Activation of the Nrf2 Antioxidant Pathway . Cell Metabolism vol. 15 , ( 3 ) 361 - 371 .
( 2011 ) . Gene therapy with hypoxia-inducible factor 1 alpha in skeletal muscle is cardioprotective in vivo . Life Sciences vol. 88 , ( 11-12 ) 543 - 550 .
( 2010 ) . Mechanisms of novel cardioprotective functions of CCN2/CTGF in myocardial ischemia-reperfusion injury . AJP Heart and Circulatory Physiology vol. 300 , ( 4 ) h1291 - h1302 .
( 2010 ) . Complex role of the HIF system in cardiovascular biology . Journal of Molecular Medicine vol. 88 , ( 11 ) 1101 - 1111 .
Czibik G, Sagave J, Martinov V, Sohl M, Sefland I, Carlsen H, Farnebo F ( 2009 ) . Cardioprotection by hypoxia-inducible factor 1 alpha transfection in skeletal muscle is dependent on haem oxygenase activity in mice . Cardiovascular Research vol. 82 , ( 1 ) 107 - 114 .
( 2009 ) . In vivo Remote Delivery of DNA Encoding for Hypoxia-inducible Factor 1 Alpha Reduces Myocardial Infarct Size . Clinical and Translational Science
( 2008 ) . Human adaptation to ischemia by preconditioning or unstable angina: involvement of nuclear factor kappa B, but not hypoxia-inducible factor 1 alpha in the heart . European Journal of Cardio-Thoracic Surgery vol. 34 , ( 5 ) 976 - 984 .
( 2007 ) . Myocardial protection evoked by hyperoxic exposure involves signaling through nitric oxide and mitogen activated protein kinases . Basic Research in Cardiology vol. 102 , ( 4 ) 318 - 326 .
( 2006 ) . Myocardial protection evoked by hyperoxic exposure involves signaling through nitric oxide and mitogen activated protein kinases . Journal of Molecular and Cellular Cardiology vol. 40 , ( 6 )
( 2006 ) . Gene Deletion of NF-κB p105 Enhances Neointima Formation in a Mouse Model of Carotid Artery Injury . Cardiovascular Drugs and Therapy vol. 20 , ( 2 ) 103 - 111 .
( 2002 ) . Robotic cardiac surgery: Present and future applications . Journal of Cardiothoracic and Vascular Anesthesia vol. 16 , ( 4 ) 495 - 501 .
Korbonits M, Wang X, Barry S, Lim CT, Suleyman O, De Tito S, Uddin N, Vignola ML et al. . Chaperone AIP Couples mTORC1 Activation and Catabolic Metabolism During Neonatal Development .
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