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  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: MISS Rachel Lau

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Bhamidipati K, McIntyre ABR, Kazerounian S, Ce G, Wong SW, Tran M, Prell SA, Lau R et al. ( 2026 ) . Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis . Nature Immunology vol. 27 , ( 3 ) 556 - 571 .
De Lima J, Boutet M-A, Bortolotti O, Chépeaux L-A, Glasson Y, Dumé A-S, Lau R, Humbert P et al. ( 2025 ) . Spatial mapping of rheumatoid arthritis synovial niches reveals a LYVE1+ macrophage network associated with response to therapy . Annals of the Rheumatic Diseases vol. 84 , ( 12 ) 1955 - 1967 .
Lewis MJ, Çubuk C, Surace AEA, Sciacca E, Lau R, Goldmann K, Giorli G, Fossati-Jimack L et al. ( 2025 ) . Deep molecular profiling of synovial biopsies in the STRAP trial identifies signatures predictive of treatment response to biologic therapies in rheumatoid arthritis . Nature Communications vol. 16 , ( 1 )
Banda N, Moreland LW, Deane KD, Simberg D, Scheinman RI, Frank RM, Clay MR, Seifert JA et al. ( 2025 ) . Analysis of human factor H-related gene and protein expression in rheumatoid arthritis synovium identifies a novel mechanism promoting dysregulated complement pathway activation . Immunobiology vol. 230 , ( 4 )
Banda NK, Moreland LW, Deane KD, Simberg D, Scheinman RI, Frank RM, Seifert JA, Lau R et al. ( 2025 ) . Analysis of human factor H-related gene and protein expressed in rheumatoid arthritis synovium identifies a novel mechanism promoting dysregulated complement pathway activation . Scientific Reports vol. 15 , ( 1 )
Martínez-Paz P, Nerviani A, Cubuk C, Lau R, Fossati-Jimack L, Rivellese F, Somma D, Alivernini S et al. ( 2025 ) . POS0070 SPECIFIC SYNOVIAL TISSUE MACROPHAGE CLUSTER SUBTYPES ARE ASSOCIATED WITH MULTI-BIOLOGIC REFRACTORINESS IN RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases vol. 84 ,
La Rosa FG, Moreland LW, Nibali L, Curtis M, Deane KD, Strickland C, Seifert J, Keeter C et al. ( 2025 ) . Pathotype-Specific Expression of Granzyme-Perforin Pathway Genes and Their Association With Clinical Disease Activity in Early Rheumatoid Arthritis and in a Randomized Clinical Trial . Immune Network vol. 25 , ( 4 )
Çubuk C, Lau R, Cutillas P, Rajeeve V, John CR, Surace AEA, Hands R, Fossati-Jimack L et al. ( 2024 ) . Phosphoproteomic profiling of early rheumatoid arthritis synovium reveals active signalling pathways and differentiates inflammatory pathotypes . Arthritis Research & Therapy vol. 26 , ( 1 )
Lau R, Cubuk C, Rajeeve V, Cutillas P, Hands R, Fossati-Jimack L, Surace A, Lewis M et al. ( 2024 ) . OP0218 SYNOVIAL PHOSPHOPROTEOME ANALYSIS OF LATE-STAGE RHEUMATOID ARTHRITIS PATIENTS (R4RA TRIAL) IDENTIFIES SIGNALLING PATHWAYS ASSOCIATED WITH PATHOTYPE AND RESPONSE TO RITUXIMAB AND TOCILIZUMAB . Annals of the Rheumatic Diseases . vol. 83 ,
Wang S, Nair N, Cubuk C, Yap CF, Lau R, Giorli G, Fossati-Jimack L, Plant D et al. ( 2024 ) . OP0224 INTEGRATION OF DNA METHYLATION INTO MULTI-OMIC ANALYSIS OF SYNOVIAL BIOPSIES FROM THE STRAP RANDOMIZED CLINICAL TRIAL IDENTIFIES PREDICTORS OF RESPONSE TO ANTI-TNF THERAPY IN RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases . vol. 83 ,
Lau R, Yu L, Roumeliotis TI, Stewart A, Pickard L, Choudhary JS, Banerji U ( 2024 ) . Secretome of Cancer-Associated Fibroblasts (CAFs) Influences Drug Sensitivity in Cancer Cells . Journal of Proteome Research vol. 23 , ( 6 ) 2160 - 2168 .
Nerviani A, Boutet M-A, Ghirardi GM, Goldmann K, Sciacca E, Rivellese F, Pontarini E, Prediletto E et al. ( 2024 ) . Axl and MerTK regulate synovial inflammation and are modulated by IL-6 inhibition in rheumatoid arthritis . Nature Communications vol. 15 , ( 1 )
Lau R, Yu L, Roumeliotis TI, Stewart A, Pickard L, Riisanes R, Gurel B, de Bono JS et al. ( 2023 ) . Unbiased differential proteomic profiling between cancer-associated fibroblasts and cancer cell lines . Journal of Proteomics vol. 288 ,
Latta C, Trinca TM, Robertson F, Lau R, Barkaway A, Rolas L, Golding M, Imbert PRC et al. . Orphan GPR84 facilitates uropod de-adhesion to terminate leukocyte diapedesis during inflammation .
Bhamidipati K, McIntyre ABR, Kazerounian S, Ce G, Tran M, Prell SA, Lau R, Khedgikar V et al. . Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis .
Wang S, Nair N, Cubuk C, Chuan Fu Y, Lau R, Giorli G, Rivellese F, Nerviani A et al. . Synovial DNA methylation signatures predict TNF inhibitor response in rheumatoid arthritis: an integrative multi-omic and machine learning analysis . Annals of the Rheumatic Diseases
Kontra I, Ward H, Vinluan F, Lau R, Rajeeve V, Cutillas P, Stieglitz B, Lewis MJ . The acidic N-terminus of HHARI and neddylation are essential for the activation and maintenance of RIG-I-mediated type I interferon response .
Lau R, Çubuk C, Spiliopoulou A, Martínez-Paz P, Surace AEA, Fossati-Jimack L, Raychaudhuri S, Pitzalis C et al. . cellGeometry: ultra-fast single-cell deconvolution of bulk RNA-Seq using a geometric solution .
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