Publications: DR Maria Fragiadaki

Terzenidou M-E, Patera F, Macleod FM, Ong ACM, Fragiadaki M ( 2025 ) . ANKHD1 promotes pathogenic proliferation in Autosomal Dominant Polycystic Kidney Disease via the Cyclin D1/CDK4 pathway . Journal of Translational Medicine vol. 23 , ( 1 )

Zhou Z, Korteland S-A, Tardajos-Ayllon B, Wu J, Chambers E, Weninck J, Simons M, Dunning M et al. ( 2024 ) . Shear stress is uncoupled from atheroprotective KLK10 in atherosclerotic plaques . Atherosclerosis vol. 398 ,

Mullenger J, Zeidler M, Fragiadaki M ( 2024 ) . ANKHD1 Has a Cytoprotective Role in Stressed Kidney Cells . Journal of the American Society of Nephrology vol. 35 , ( 10S )

Ahmed E, Fragiadaki M ( 2024 ) . Influence of PKD1-Mediated Apoptosis on Proliferation and Autophagy in Human Embryonic Kidney Cells . Journal of the American Society of Nephrology vol. 35 , ( 10S )

Terzenidou M-E, Macleod F, Fragiadaki M ( 2024 ) . Role of Ankyrin Repeat and Single KH Domain 1 in Autosomal Dominant Polycystic Kidney Disease Pathogenesis and CyclinD1/CDK4-Induced Proliferation . Journal of the American Society of Nephrology vol. 35 , ( 10S )

Macleod F, Fragiadaki M ( 2024 ) . Targeting Growth Hormone/JAK2 Signaling as a Novel Therapy for Polycystic Kidney Disease Treatment . Journal of the American Society of Nephrology vol. 35 , ( 10S )

Pirri D, Tian S, Tardajos-Ayllon B, Irving SE, Donati F, Allen SP, Mammoto T, Vilahur G et al. ( 2024 ) . EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites Through Endothelial Fatty Acid Uptake . Circulation Research vol. 135 , ( 8 ) 822 - 837 .

Mullenger JL, Zeidler MP, Fragiadaki M ( 2023 ) . Evaluating the Molecular Properties and Function of ANKHD1, and Its Role in Cancer . International Journal of Molecular Sciences vol. 24 , ( 16 )

Tian S, Pirri D, Tardajos-Ayllon B, Fragiadaki M, Evans PC ( 2023 ) . BS2 Flow-regulated EPAS1 limits atherosclerosis via metabolic control of endothelial proliferation . Conference: Basic Sciencea247.2 - a2a247 .

Souilhol C, Tardajos Ayllon B, Li X, Diagbouga MR, Zhou Z, Canham L, Roddie H, Pirri D et al. ( 2022 ) . JAG1-NOTCH4 mechanosensing drives atherosclerosis . Science Advances vol. 8 , ( 35 )

Zhou Z, Wu J, Wentzel J, Schenkel T, Diagbouga M, Fragiadaki M, Simons M, Evans P ( 2022 ) . BS21 Endothelial cell profile in responses to high shear stress is different in healthy arteries and plaques . Conference: Basic sciencea158 - a159 .

Fragiadaki M ( 2022 ) . Lessons from microRNA biology: Top key cellular drivers of Autosomal Dominant Polycystic Kidney Disease . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease vol. 1868 , ( 5 )

Zhou Z, Van-Hateren N, Francis S, Fragiadaki M, Evans P ( 2021 ) . BS30 Light sheet imaging to analyse the spatial distribution of proteins in atherosclerotic plaques . Heart . Conference: Basic science vol. 107 , a172 - a173 .

Fragiadaki M, Macleod FM, Ong ACM ( 2020 ) . The Controversial Role of Fibrosis in Autosomal Dominant Polycystic Kidney Disease . International Journal of Molecular Sciences vol. 21 , ( 23 )

Evans PC, Fragiadaki M, Morris PD, Serbanovic-Canic J ( 2020 ) . Shear stress: the dark energy of atherosclerotic plaques . Cardiovascular Research vol. 117 , ( 8 ) 1811 - 1813 .

Pirri D, Fragiadaki M, Evans PC ( 2020 ) . Diabetic atherosclerosis: is there a role for the hypoxia-inducible factors? . Bioscience Reports vol. 40 , ( 8 )

Evans PC, Rainger GE, Mason JC, Guzik TJ, Osto E, Stamataki Z, Neil D, Hoefer IE et al. ( 2020 ) . Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science . Cardiovascular Research vol. 116 , ( 14 ) 2177 - 2184 .

Souilhol C, Gauci I, Feng S, Ayllon BT, Mahmoud M, Canham L, Fragiadaki M, Serbanovic-Canic J et al. ( 2019 ) . Homeobox B9 integrates bone morphogenic protein 4 with inflammation at atheroprone sites . Cardiovascular Research vol. 116 , ( 7 ) 1300 - 1310 .

Souilhol C, Serbanovic-Canic J, Fragiadaki M, Chico TJ, Ridger V, Roddie H, Evans PC ( 2019 ) . Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes . Nature Reviews Cardiology vol. 17 , ( 1 ) 52 - 63 .

Xanthis I, Souilhol C, Serbanovic-Canic J, Roddie H, Kalli AC, Fragiadaki M, Wong R, Shah DR et al. ( 2019 ) . β1 integrin is a sensor of blood flow direction . Journal of Cell Science vol. 132 , ( 11 )

Roddie H, Fragiadaki M, Evans P ( 2019 ) . BS28 Endothelial STAT5A is enriched at atheroprone regions of the aorta and drives inflammation in response to low shear stress . Heart . Conference: Basic Science vol. 105 ,

Patera F, Cudzich-Madry A, Huang Z, Fragiadaki M ( 2019 ) . Renal expression of JAK2 is high in polycystic kidney disease and its inhibition reduces cystogenesis . Scientific Reports vol. 9 , ( 1 )

Fragiadaki M, Evans PC ( 2018 ) . The Bernard and Joan Marshall Early Career Investigators and Distinguished Investigator Award 2018 . Cardiovascular Drugs and Therapy vol. 33 , ( 2 ) 203 - 205 .

Fisher KH, Fragiadaki M, Pugazhendhi D, Bausek N, Arredondo MA, Thomas SJ, Brown S, Zeidler MP ( 2018 ) . A genome-wide RNAi screen identifies MASK as a positive regulator of cytokine receptor stability . Journal of Cell Science vol. 131 , ( 13 )

Fragiadaki M, Zeidler MP ( 2018 ) . Ankyrin repeat and single KH domain 1 (ANKHD1) drives renal cancer cell proliferation via binding to and altering a subset of miRNAs . Journal of Biological Chemistry vol. 293 , ( 25 ) 9570 - 9579 .

Feng S, Fragiadaki M, Souilhol C, Ridger V, Evans PC ( 2017 ) . Response by Feng et al to Letter Regarding Article, “Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites” . Arteriosclerosis Thrombosis and Vascular Biology vol. 37 , ( 12 ) e199 - e200 .

Feng S, Bowden N, Fragiadaki M, Souilhol C, Hsiao S, Mahmoud M, Allen S, Pirri D et al. ( 2017 ) . Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites . Arteriosclerosis Thrombosis and Vascular Biology vol. 37 , ( 11 ) 2087 - 2101 .

Fragiadaki M, Lannoy M, Themanns M, Maurer B, Leonhard WN, Peters DJM, Moriggl R, Ong ACM ( 2017 ) . STAT5 drives abnormal proliferation in autosomal dominant polycystic kidney disease . Kidney International vol. 91 , ( 3 ) 575 - 586 .

Ikeda T, Fragiadaki M, Shi-wen X, Ponticos M, Khan K, Denton C, Garcia P, Bou-Gharios G et al. ( 2016 ) . Data on CUX1 isoforms in idiopathic pulmonary fibrosis lung and systemic sclerosis skin tissue sections . Data in Brief vol. 8 , 1377 - 1380 .

Ikeda T, Fragiadaki M, Shi-wen X, Ponticos M, Khan K, Denton C, Garcia P, Bou-Gharios G et al. ( 2016 ) . Transforming growth factor-β-induced CUX1 isoforms are associated with fibrosis in systemic sclerosis lung fibroblasts . Biochemistry and Biophysics Reports vol. 7 , 246 - 252 .

Luong LA, Fragiadaki M, Smith J, Boyle J, Lutz J, Dean JLE, Harten S, Ashcroft M et al. ( 2013 ) . Cezanne Regulates Inflammatory Responses to Hypoxia in Endothelial Cells by Targeting TRAF6 for Deubiquitination . Circulation Research vol. 112 , ( 12 ) 1583 - 1591 .

Fragiadaki M, Hill N, Hewitt R, Bou-Gharios G, Cook T, Tam FW, Domin J, Mason RM ( 2012 ) . Hyperglycemia Causes Renal Cell Damage via CCN2-Induced Activation of the TrkA Receptor Implications for Diabetic Nephropathy . Diabetes vol. 61 , ( 9 ) 2280 - 2288 .

Fragiadaki M, Witherden AS, Kaneko T, Sonnylal S, Pusey CD, Bou-Gharios G, Mason RM ( 2011 ) . Interstitial fibrosis is associated with increased COL1A2 transcription in AA-injured renal tubular epithelial cells in vivo . Matrix Biology vol. 30 , ( 7-8 ) 396 - 403 .

Fragiadaki M, Mason RM ( 2011 ) . Epithelial‐mesenchymal transition in renal fibrosis – evidence for and against . International Journal of Experimental Pathology vol. 92 , ( 3 ) 143 - 150 .

Fragiadaki M, Ikeda T, Witherden A, Mason RM, Abraham D, Bou-Gharios G ( 2011 ) . High doses of TGF-β potently suppress type I collagen via the transcription factor CUX1 . Molecular Biology of the Cell vol. 22 , ( 11 ) 1836 - 1844 .

Patera F, Hautbergue GM, Wilson P, Evans PC, Ong AC, Fragiadaki M . Ankhd1 enhances polycystic kidney disease development via promoting proliferation and fibrosis .

Pirri D, Tian S, Tardajos-Ayllon B, Irving S, Donati F, Allen SP, Mammoto T, Vilahur G et al. . EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites through Endothelial Fatty Acid Uptake .

Souilhol C, Li X, Canham L, Roddie H, Pirri D, Ayllon BT, Chambers EV, Dunning MJ et al. . JAG1-NOTCH4 Mechanosensing Drives Atherosclerosis .

Xanthis I, Souilhol C, Serbanovic-Canic J, Roddie H, Kalli AC, Fragiadaki M, Wong R, Shah DR et al. . β1 integrin is a sensor of blood flow direction .