Publications: PROF Claudia Langenberg

Fatumo S, Ojewunmi O, Camenzuli R, Kintu C, Kamiza A, Brandenburg J-T, Kalungi A, Kalyesubula R et al. ( 2025 ) . KidneyGenAfrica, a pan-African partnership to deliver research and training excellence in genomics of kidney disease . Nature Genetics

Pietzner M, Williamson A, Hunt KA, Koprulu M, Kohleick L, Demircan K, Finer S, Zanini JC et al. ( 2025 ) . Nanoparticle enriched mass spectrometry proteomics in British South Asians identifies novel variant-protein-disease mechanisms .

Asiimwe IG, Jorgensen AL, Pirmohamed M ( 2025 ) . <scp><i>APOE</i></scp> Genotype and Statin Response: Evidence From the <scp>UK</scp> Biobank and All of Us Program . Clinical and Translational Science vol. 18 , ( 8 ) Article e70314 ,

Smit RAJ, Wade KH, Hui Q, Arias JD, Yin X, Christiansen MR, Yengo L, Preuss MH et al. ( 2025 ) . Polygenic prediction of body mass index and obesity through the life course and across ancestries . Nature Medicine

Makhmudova U, Wild B, Williamson A, Steinhagen-Thiessen E, Langenberg C, Eils R, Landmesser U, Sannino A ( 2025 ) . Visceral adipose tissue, aortic distensibility and atherosclerotic cardiovascular risk across body mass index categories . European Journal of Preventive Cardiology Article zwaf447 ,

Robinson O, Xiao H, Homann J, Viallon V, Ferrari P, Huerta J, Jiménez-Zabala A, Kaaks R et al. ( 2025 ) . Associations of proteomic age with mortality and incident chronic diseases in the European Prospective Investigation into Cancer and Nutrition (EPIC) .

Torralbo A, Davitte JM, Croteau-Chonka DC, Ytsma C, Tomlinson C, Fitzpatrick NK, Chung S-C, Fatemifar G et al. ( 2025 ) . A computational framework for defining and validating reproducible phenotyping algorithms of 313 diseases in the UK Biobank . Scientific Reports vol. 15 , ( 1 ) Article 24607 ,

Kim HI, DeBoever C, Walter K, Kalantzis G, Li C, Mozaffari SV, Kundu K, Jacobs BM et al. ( 2025 ) . Exome sequencing and analysis of 44,028 British South Asians enriched for high autozygosity .

Koprulu M, Wheeler E, Kerrison ND, Denaxas S, Carrasco-Zanini J, Orkin CM, Hemingway H, Wareham NJ et al. ( 2025 ) . Sex differences in the genetic regulation of the human plasma proteome . Nature Communications vol. 16 , ( 1 ) Article 4001 ,

( 2025 ) . Understanding the potential contribution of polygenic risk scores to the prediction of gestational and type 2 diabetes in women from British Pakistani and Bangladeshi groups: a cohort study in Genes and Health . AJOG Global Reports vol. 5 , ( 2 ) Article 100457 , 100457 - 100457 .

( 2025 ) . Inherited predisposition to pneumothorax: estimating the frequency of Birt-Hogg-Dub� syndrome from genomics and population cohorts . Thorax vol. 80 , ( 8 ) 553 - 555 .

Henry A, Mo X, Finan C, Chaffin MD, Speed D, Issa H, Denaxas S, Ware JS et al. ( 2025 ) . Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes . Nature Genetics vol. 57 , ( 4 ) 815 - 828 .

Ferolito BR, Dashti H, Giambartolomei C, Peloso GM, Golden DJ, Gravel-Pucillo K, Rasooly D, Horimoto ARVR et al. ( 2025 ) . Leveraging Large-Scale Biobanks for Therapeutic Target Discovery .

Steinfeldt J, Wild B, Buergel T, Pietzner M, Upmeier zu Belzen J, Vauvelle A, Hegselmann S, Denaxas S et al. ( 2025 ) . Author Correction: Medical history predicts phenome-wide disease onset and enables the rapid response to emerging health threats . Nature Communications vol. 16 , ( 1 ) Article 1507 ,

Rasooly D, Giambartolomei C, Peloso GM, Dashti H, Ferolito BR, Golden D, Horimoto ARVR, Pietzner M et al. ( 2025 ) . Large-scale multi-omics identifies drug targets for heart failure with reduced and preserved ejection fraction . Nature Cardiovascular Research vol. 4 , ( 3 ) 293 - 311 .

Zoodsma M, Beuchel C, Yasmeen S, Kohleick L, Nepal A, Koprulu M, Kronenberg F, Mayr M et al. ( 2025 ) . A genetic map of human metabolism across the allele frequency spectrum .

Yoshiji S, Lu T, Butler-Laporte G, Carrasco-Zanini-Sanchez J, Su C-Y, Chen Y, Liang K, Willett JDS et al. ( 2025 ) . Integrative proteogenomic analysis identifies COL6A3-derived endotrophin as a mediator of the effect of obesity on coronary artery disease . Nature Genetics vol. 57 , ( 2 ) 345 - 357 .

Steinfeldt J, Wild B, Buergel T, Pietzner M, Upmeier zu Belzen J, Vauvelle A, Hegselmann S, Denaxas S et al. ( 2025 ) . Medical history predicts phenome-wide disease onset and enables the rapid response to emerging health threats . Nature Communications vol. 16 , ( 1 ) Article 585 ,

Pietzner M, Beuchel C, Demircan K, Anton JH, Zeng W, Römisch-Margl W, Yasmeen S, Uluvar B et al. ( 2025 ) . Machine learning-guided deconvolution of plasma protein levels .

( 2025 ) . Altered IL-6 signalling and risk of tuberculosis: a multi-ancestry mendelian randomisation study . The Lancet Microbe vol. 6 , ( 1 ) Article 100922 , 100922 - 100922 .

Gharibzadeh S, Routen A, Razieh C, Zaccardi F, Lawson C, Gillies C, Heller S, Davies M et al. ( 2025 ) . Long term health outcomes in people with diabetes 12 months after hospitalisation with COVID-19 in the UK: a prospective cohort study . eClinicalMedicine vol. 79 , Article 103005 , 103005 - 103005 .

( 2024 ) . Genetic basis of early onset and progression of type 2 diabetes in South Asians . Nature Medicine vol. 31 , ( 1 ) 323 - 331 .

Tyrer F, Gharibzadeh S, Gillies C, Lawson C, Routen A, Islam N, Razieh C, Zaccardi F et al. ( 2024 ) . Incidence of diabetes mellitus following hospitalisation for <scp>COVID</scp>‐19 in the United Kingdom: A prospective observational study . Diabetes, Obesity and Metabolism vol. 27 , ( 2 ) 767 - 776 .

( 2024 ) . Genetic architecture of routinely acquired blood tests in a British South Asian cohort . Nature Communications vol. 15 , ( 1 ) Article 8929 ,

Gordillo-Marañón M, Schmidt AF, Warwick A, Tomlinson C, Ytsma C, Engmann J, Torralbo A, Maclean R et al. ( 2024 ) . Disease coverage of human genome-wide association studies and pharmaceutical research and development . Communications Medicine vol. 4 , ( 1 ) Article 195 ,

Chen Y, Butler-Laporte G, Liang KYH, Ilboudo Y, Yasmeen S, Sasako T, Langenberg C, Greenwood CMT et al. ( 2024 ) . The performance of AlphaMissense to identify genes influencing disease . Human Genetics and Genomics Advances vol. 5 , ( 4 ) Article 100344 , 100344 - 100344 .

Carrasco-Zanini J, Wheeler E, Uluvar B, Kerrison N, Koprulu M, Wareham NJ, Pietzner M, Langenberg C ( 2024 ) . Mapping biological influences on the human plasma proteome beyond the genome . Nature Metabolism vol. 6 , ( 10 ) 2010 - 2023 .

Lockhart SM, Muso M, Zvetkova I, Lam BYH, Ferrari A, Schoenmakers E, Duckett K, Leslie J et al. ( 2024 ) . Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health . Nature Metabolism vol. 6 , ( 10 ) 1922 - 1938 .

Lockhart S, Muso M, Zvetkova I, Lam B, Ferrari A, Schoenmakkers E, Duckett K, Leslie J et al. ( 2024 ) . Damaging mutations in LXR[alpha] uncouple lipogenesis from hepatotoxicity and implicate hepatic cholesterol sensing in human liver health . Endocrine Abstracts

Taquet M, Skorniewska Z, De Deyn T, Hampshire A, Trender WR, Hellyer PJ, Chalmers JD, Ho L-P et al. ( 2024 ) . Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK . The Lancet Psychiatry vol. 11 , ( 9 ) 696 - 708 .

Stefanucci L, Moslemi C, Tomé AR, Virtue S, Bidault G, Gleadall NS, Watson LPE, Kwa JE et al. ( 2024 ) . SMIM1 absence is associated with reduced energy expenditure and excess weight . Med vol. 5 , ( 9 ) 1083 - 1095.e6 .

Alwan H, Luan J, Williamson A, Carrasco-Zanini J, Stewart ID, Wareham NJ, Langenberg C, Pietzner M ( 2024 ) . Testing for a causal role of thyroid hormone measurements within the normal range on human metabolism and diseases: a systematic Mendelian randomization . eBioMedicine vol. 107 , Article 105306 , 105306 - 105306 .

Repetto L, Chen J, Yang Z, Zhai R, Timmers PRHJ, Feng X, Li T, Yao Y et al. ( 2024 ) . The genetic landscape of neuro-related proteins in human plasma . Nature Human Behaviour vol. 8 , ( 11 ) 2222 - 2234 .

( 2024 ) . An <i>LGR6</i> frameshift variant abrogates receptor expression on select leukocyte subsets and is associated with viral infections . Blood vol. 144 , ( 4 ) 420 - 434 .

( 2024 ) . Blood proteins predict the risk of many diseases years before onset . Nature Medicine vol. 30 , ( 9 ) 2419 - 2420 .

Carrasco-Zanini J, Pietzner M, Davitte J, Surendran P, Croteau-Chonka DC, Robins C, Torralbo A, Tomlinson C et al. ( 2024 ) . Proteomic signatures improve risk prediction for common and rare diseases . Nature Medicine vol. 30 , ( 9 ) 2489 - 2498 .

Lim SS, Semnani-Azad Z, Morieri ML, Ng AH, Ahmad A, Fitipaldi H, Boyle J, Collin C et al. ( 2024 ) . Reporting guidelines for precision medicine research of clinical relevance: the BePRECISE checklist . Nature Medicine vol. 30 , ( 7 ) 1874 - 1881 .

Pietzner M, Denaxas S, Yasmeen S, Ulmer MA, Nakanishi T, Arnold M, Kastenmüller G, Hemingway H et al. ( 2024 ) . Complex patterns of multimorbidity associated with severe COVID-19 and long COVID . Communications Medicine vol. 4 , ( 1 ) Article 94 ,

Desai TA, Hedman ÅK, Dimitriou M, Koprulu M, Figiel S, Yin W, Johansson M, Watts EL et al. ( 2024 ) . Identifying proteomic risk factors for overall, aggressive, and early onset prostate cancer using Mendelian Randomisation and tumour spatial transcriptomics . eBioMedicine vol. 105 , Article 105168 , 105168 - 105168 .

Carrasco-Zanini J, Pietzner M, Koprulu M, Wheeler E, Kerrison ND, Wareham NJ, Langenberg C ( 2024 ) . Proteomic prediction of diverse incident diseases: a machine learning-guided biomarker discovery study using data from a prospective cohort study . The Lancet Digital Health vol. 6 , ( 7 ) e470 - e479 .

Gaziano L, Allara E, Giambartolomei C, Stacey D, Zhao JH, Dashti H, Jiang T, Ritchie SC et al. ( 2024 ) . Transcriptome- and proteome-wide Mendelian randomization to prioritize therapeutic targets for coronary heart disease .

Ganji-Arjenaki M, Kamali Z, Evangelou E, Warren HR, Gao H, Ntritsos G, Dimou N, Esko T et al. ( 2024 ) . Prioritization of Kidney Cell Types Highlights Myofibroblast Cells in Regulating Human Blood Pressure . Kidney International Reports vol. 9 , ( 6 ) 1849 - 1859 .

Lawson CA, Moss AJ, Arnold JR, Bagot C, Banerjee A, Berry C, Greenwood J, Hughes AD et al. ( 2024 ) . Long COVID and cardiovascular disease: a prospective cohort study . Open Heart vol. 11 , ( 1 ) e002662 - e002662 .

Steinfeldt J, Wild B, Buergel T, Pietzner M, Upmeier zu Belzen J, Vauvelle A, Hegselmann S, Denaxas S et al. ( 2024 ) . RETRACTED ARTICLE: Medical history predicts phenome-wide disease onset and enables the rapid response to emerging health threats . Nature Communications vol. 15 , ( 1 ) Article 4257 ,

Keaton JM, Kamali Z, Xie T, Vaez A, Williams A, Goleva SB, Ani A, Evangelou E et al. ( 2024 ) . Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits . Nature Genetics vol. 56 , ( 5 ) 778 - 791 .

Lockhart SM, Muso M, Zvetkova I, Lam BYH, Ferrari A, Schoenmakers E, Duckett K, Leslie J et al. ( 2024 ) . Damaging mutations in LXRα uncouple lipogenesis from hepatotoxicity and implicate hepatic cholesterol sensing in human liver health .

Smith-Byrne K, Hedman Å, Dimitriou M, Desai T, Sokolov AV, Schioth HB, Koprulu M, Pietzner M et al. ( 2024 ) . Identifying therapeutic targets for cancer among 2074 circulating proteins and risk of nine cancers . Nature Communications vol. 15 , ( 1 ) Article 3621 ,

Shrine N, Guyatt AL, Erzurumluoglu AM, Jackson VE, Hobbs BD, Melbourne CA, Batini C, Fawcett KA et al. ( 2024 ) . Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries . Nature Genetics vol. 56 , ( 5 ) 1032 - 1033 .

Liew F, Efstathiou C, Fontanella S, Richardson M, Saunders R, Swieboda D, Sidhu JK, Ascough S et al. ( 2024 ) . Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease . Nature Immunology vol. 25 , ( 4 ) 607 - 621 .

Elneima O, Hurst JR, Echevarria C, Quint JK, Walker S, Siddiqui S, Novotny P, Pfeffer PE et al. ( 2024 ) . Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study – PHOSP-COVID . ERJ Open Research vol. 10 , ( 4 ) 00982 - 2023 .

Rasooly D, Giambartolomei C, Peloso GM, Dashti H, Ferolito BR, Golden D, Horimoto ARVR, Pietzner M et al. ( 2024 ) . Large-scale Mendelian randomization identifies novel pathways as therapeutic targets for heart failure with reduced ejection fraction and with preserved ejection fraction .

Desai TA, Hedman AK, Dimitriou M, Koprulu M, Figiel S, Yin W, Johansson M, Watts EL et al. ( 2024 ) . Abstract 7330: Identifying proteomic risk factors for overall, aggressive and early onset prostate cancer using mendelian randomization and tumor spatial transcriptomics . Cancer Research vol. 84 , ( 6_Supplement ) 7330 - 7330 .

Buergel T, Loock L, Steinfeldt J, Hoffmann L, Künzel SE, Upmeier zu Belzen J, Khawaja AP, Luben R et al. ( 2024 ) . A predictive atlas of disease onset from retinal fundus photographs .

( 2024 ) . Partitioned polygenic scores highlight role of beta-cell function and unfavourable fat distribution patterns in young onset type 2 diabetes in south Asians .

Chen Y, Butler-Laporte G, Liang KYH, Ilboudo Y, Yasmeen S, Sasako T, Langenberg C, Greenwood CMT et al. ( 2024 ) . The performance of AlphaMissense to identify genes causing disease .

Pietzner M, Uluvar B, Kolnes KJ, Jeppesen PB, Frivold SV, Skattebo Ø, Johansen EI, Skålhegg BS et al. ( 2024 ) . Systemic proteome adaptions to 7-day complete caloric restriction in humans . Nature Metabolism vol. 6 , ( 4 ) 764 - 777 .

Suzuki K, Hatzikotoulas K, Southam L, Taylor HJ, Yin X, Lorenz KM, Mandla R, Huerta-Chagoya A et al. ( 2024 ) . Genetic drivers of heterogeneity in type 2 diabetes pathophysiology . Nature vol. 627 , ( 8003 ) 347 - 357 .

Koprulu M, Wheeler E, Kerrison ND, Denaxas S, Carrasco-Zanini J, Orkin CM, Hemingway H, Wareham NJ et al. ( 2024 ) . Similar and different: systematic investigation of proteogenomic variation between sexes and its relevance for human diseases .

Sterenborg RBTM, Steinbrenner I, Li Y, Bujnis MN, Naito T, Marouli E, Galesloot TE, Babajide O et al. ( 2024 ) . Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications . Nature Communications vol. 15 , ( 1 ) Article 888 ,

Lord JM, Veenith T, Sullivan J, Sharma-Oates A, Richter AG, Greening NJ, McAuley HJC, Evans RA et al. ( 2024 ) . Accelerated immune ageing is associated with COVID-19 disease severity . Immunity &amp; Ageing vol. 21 , ( 1 ) Article 6 ,

Sofianopoulou E, Kaptoge SK, Afzal S, Jiang T, Gill D, Gundersen TE, Bolton TR, Allara E et al. ( 2024 ) . Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses . The Lancet Diabetes &amp; Endocrinology vol. 12 , ( 1 ) e2 - e11 .

Noce D, Foco L, Orth-Höller D, König E, Barbieri G, Pietzner M, Ghasemi-Semeskandeh D, Coassin S et al. ( 2024 ) . Genetic determinants of complement activation in the general population . Cell Reports vol. 43 , ( 1 ) Article 113611 , 113611 - 113611 .

Elneima O, McAuley HJC, Leavy OC, Chalmers JD, Horsley A, Ho L-P, Marks M, Poinasamy K et al. ( 2023 ) . Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study . International Journal of Epidemiology vol. 53 , ( 1 ) Article dyad165 ,

Trichia E, Koulman A, Stewart ID, Brage S, Griffin SJ, Griffin JL, Khaw K, Langenberg C et al. ( 2023 ) . Plasma Metabolites Related to the Consumption of Different Types of Dairy Products and Their Association with New‐Onset Type 2 Diabetes: Analyses in the Fenland and EPIC‐Norfolk Studies, United Kingdom . Molecular Nutrition &amp; Food Research vol. 68 , ( 1 ) Article 2300154 ,

Iglesias MJ, Sanchez-Rivera L, Ibrahim-Kosta M, Naudin C, Munsch G, Goumidi L, Farm M, Smith PM et al. ( 2023 ) . Author Correction: Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism . Nature Communications vol. 14 , ( 1 ) Article 7752 ,

Tin A, Fohner AE, Yang Q, Brody JA, Davies G, Yao J, Liu D, Caro I et al. ( 2023 ) . Identification of circulating proteins associated with general cognitive function among middle-aged and older adults . Communications Biology vol. 6 , ( 1 ) Article 1117 ,

Yoshiji S, Lu T, Butler-Laporte G, Carrasco-Zanini-Sanchez J, Chen Y, Liang K, Willett J, Su C et al. ( 2023 ) . INTEGRATIVE PROTEOGENOMICS ANALYSIS IDENTIFIES COL6A3-DERIVED ENDOTROPHIN AS AN ACTIONABLE MEDIATOR OF THE EFFECT OF OBESITY ON CORONARY ARTERY DISEASE . Canadian Journal of Diabetes vol. 47 , ( 7 ) S173 - S173 .

Brightling CE, Evans RA, Singapuri A, Smith N, Wain LV, Brightling CE, Evans RA, Wain LV et al. ( 2023 ) . Long COVID research: an update from the PHOSP-COVID Scientific Summit . The Lancet Respiratory Medicine vol. 11 , ( 11 ) e93 - e94 .

Raman B, McCracken C, Cassar MP, Moss AJ, Finnigan L, Samat AHA, Ogbole G, Tunnicliffe EM et al. ( 2023 ) . Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study . The Lancet Respiratory Medicine vol. 11 , ( 11 ) 1003 - 1019 .

Carrasco-Zanini J, Pietzner M, Wheeler E, Kerrison ND, Langenberg C, Wareham NJ ( 2023 ) . Multi-omic prediction of incident type 2 diabetes . Diabetologia vol. 67 , ( 1 ) 102 - 112 .

Willems SM, Ng NHJ, Fernandez J, Fine RS, Wheeler E, Wessel J, Kitajima H, Marenne G et al. ( 2023 ) . Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization . Wellcome Open Research vol. 8 , 483 - 483 .

Willems SM, Ng NHJ, Fernandez J, Fine RS, Wheeler E, Wessel J, Kitajima H, Marenne G et al. ( 2023 ) . Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization . Wellcome open research vol. 8 ,

( 2023 ) . Genetic architecture of routinely acquired blood tests in a UK cohort of South Asian ancestry reveals ancestry-specific causal variants .

Hingorani AD, Gratton J, Finan C, Schmidt AF, Patel R, Sofat R, Kuan V, Langenberg C et al. ( 2023 ) . Performance of polygenic risk scores in screening, prediction, and risk stratification: secondary analysis of data in the Polygenic Score Catalog . BMJ Medicine vol. 2 , ( 1 ) e000554 - e000554 .

( 2023 ) . ADRA2A and IRX1 are putative risk genes for Raynaud’s phenomenon . Nature Communications vol. 14 , ( 1 ) Article 6156 ,

Yoshiji S, Lu T, Butler-Laporte G, Carrasco-Zanini-Sanchez J, Chen Y, Liang K, Sunday Willett JD, Su C-Y et al. ( 2023 ) . THU582 Actionable Circulating Proteins Mediate The Effect Of Obesity On Cardiometabolic Diseases: An Integrative Proteogenomics Analysis . Journal of the Endocrine Society vol. 7 , ( Supplement_1 ) Article bvad114.580 ,

Henry A, Mo X, Finan C, Chaffin MD, Speed D, Issa H, Denaxas S, Ware JS et al. ( 2023 ) . Mapping the aetiological foundations of the heart failure spectrum using human genetics .

Yoshiji S, Lu T, Butler-Laporte G, Carrasco-Zanini-Sanchez J, Chen Y, Liang K, Willett J, Su C et al. ( 2023 ) . INTEGRATIVE PROTEOGENOMICS ANALYSIS IDENTIFIES COL6A3-DERIVED ENDOTROPHIN AS AN ACTIONABLE MEDIATOR OF THE EFFECT OF OBESITY ON CORONARY ARTERY DISEASE . Canadian Journal of Cardiology vol. 39 , ( 10 ) S209 - S210 .

Shrine N, Izquierdo AG, Chen J, Packer R, Hall RJ, Guyatt AL, Batini C, Thompson RJ et al. ( 2023 ) . Author Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk . Nature Genetics vol. 55 , ( 10 ) 1778 - 1779 .

Desai TA, Hedman ÅK, Dimitriou M, Koprulu M, Figiel S, Yin W, Johansson M, Watts EL et al. ( 2023 ) . Identifying proteomic risk factors for overall, aggressive and early onset prostate cancer using Mendelian randomization and tumor spatial transcriptomics .

Lagou V, Jiang L, Ulrich A, Zudina L, González KSG, Balkhiyarova Z, Faggian A, Maina JG et al. ( 2023 ) . GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification . Nature Genetics vol. 55 , ( 9 ) 1448 - 1461 .

Noce D, Foco L, Orth-Höller D, König E, Barbieri G, Pietzner M, Coassin S, Fuchsberger C et al. ( 2023 ) . 176 A genome-wide association screening of complement activation from a general population study . Immunobiology vol. 228 , ( 5 ) Article 152626 , 152626 - 152626 .

Alwan H, Luan J, Williamson A, Steward I, Wareham N, Langenberg C, Pietzner M ( 2023 ) . Testing for a causal role of thyroid hormone measurements within the normal range: a systematic mendelian randomization study . Endocrine Abstracts

Zhou S, Sosina OA, Bovijn J, Laurent L, Sharma V, Akbari P, Forgetta V, Jiang L et al. ( 2023 ) . Converging evidence from exome sequencing and common variants implicates target genes for osteoporosis . Nature Genetics vol. 55 , ( 8 ) 1277 - 1287 .

Carland C, Png G, Malarstig A, Kho PF, Gustafsson S, Michaelsson K, Lind L, Tsafantakis E et al. ( 2023 ) . Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases . Clinical Proteomics vol. 20 , ( 1 ) Article 31 ,

Zheng J, Wheeler E, Pietzner M, Andlauer TFM, Yau MS, Hartley AE, Brumpton BM, Rasheed H et al. ( 2023 ) . Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and Its Risk Factors: Evidence From a <scp>Genome‐Wide</scp> Association <scp>Meta‐Analysis</scp> Followed by Mendelian Randomization . Arthritis &amp; Rheumatology vol. 75 , ( 10 ) 1781 - 1792 .

Jackson C, Stewart ID, Plekhanova T, Cunningham PS, Hazel AL, Al-Sheklly B, Aul R, Bolton CE et al. ( 2023 ) . Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study . The Lancet Respiratory Medicine vol. 11 , ( 8 ) 673 - 684 .

van der Spek A, Stewart ID, Kühnel B, Pietzner M, Alshehri T, Gauß F, Hysi PG, MahmoudianDehkordi S et al. ( 2023 ) . Circulating metabolites modulated by diet are associated with depression . Molecular Psychiatry vol. 28 , ( 9 ) 3874 - 3887 .

Carrasco-Zanini J, Pietzner M, Davitte J, Surendran P, Croteau-Chonka DC, Robins C, Torralbo A, Tomlinson C et al. ( 2023 ) . Proteomic prediction of common and rare diseases .

Langenberg C, Hingorani AD, Whitty CJM ( 2023 ) . Biological and functional multimorbidity—from mechanisms to management . Nature Medicine vol. 29 , ( 7 ) 1649 - 1657 .

Rasooly D, Peloso GM, Pereira AC, Dashti H, Giambartolomei C, Wheeler E, Aung N, Ferolito BR et al. ( 2023 ) . Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure . Nature Communications vol. 14 , ( 1 ) Article 3826 ,

Cai L, Gonzales T, Wheeler E, Kerrison ND, Day FR, Langenberg C, Perry JRB, Brage S et al. ( 2023 ) . Causal associations between cardiorespiratory fitness and type 2 diabetes . Nature Communications vol. 14 , ( 1 ) Article 3904 ,

Williamson A, Norris DM, Yin X, Broadaway KA, Moxley AH, Vadlamudi S, Wilson EP, Jackson AU et al. ( 2023 ) . Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake . Nature Genetics vol. 55 , ( 6 ) 973 - 983 .

Iglesias MJ, Sanchez-Rivera L, Ibrahim-Kosta M, Naudin C, Munsch G, Goumidi L, Farm M, Smith PM et al. ( 2023 ) . Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism . Nature Communications vol. 14 , ( 1 ) Article 3280 ,

Zheng B, Vivaldi G, Daines L, Leavy OC, Richardson M, Elneima O, McAuley HJC, Shikotra A et al. ( 2023 ) . Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls . The Lancet Regional Health - Europe vol. 29 , Article 100635 , 100635 - 100635 .

Pietzner M, Denaxas S, Yasmeen S, Ulmer MA, Nakanishi T, Arnold M, Kastenmüller G, Hemingway H et al. ( 2023 ) . Complex patterns of multimorbidity associated with severe COVID-19 and Long COVID .

Graham SE, Clarke SL, Wu K-HH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I et al. ( 2023 ) . Author Correction: The power of genetic diversity in genome-wide association studies of lipids . Nature vol. 618 , ( 7965 ) E19 - E20 .

Li JH, Brenner LN, Kaur V, Figueroa K, Schroeder P, Huerta-Chagoya A, Chen J, Spracklen CN et al. ( 2023 ) . Genome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH . Diabetologia vol. 66 , ( 7 ) 1260 - 1272 .

Smith-Byrne K, Hedman Å, Dimitriou M, Desai T, Sokolov AV, Schioth HB, Koprulu M, Pietzner M et al. ( 2023 ) . Identifying therapeutic targets for cancer: 2,094 circulating proteins and risk of nine cancers .

Yoshiji S, Lu T, Butler-Laporte G, Carrasco-Zanini-Sanchez J, Chen Y, Liang K, Willett JDS, Su C-Y et al. ( 2023 ) . COL6A3-derived endotrophin mediates the effect of obesity on coronary artery disease: an integrative proteogenomics analysis .

Su C-Y, Zhou S, Gonzalez-Kozlova E, Butler-Laporte G, Brunet-Ratnasingham E, Nakanishi T, Jeon W, Morrison DR et al. ( 2023 ) . Circulating proteins to predict COVID-19 severity . Scientific Reports vol. 13 , ( 1 ) Article 6236 ,

Suzuki K, Hatzikotoulas K, Southam L, Taylor HJ, Yin X, Lorenz KM, Mandla R, Huerta-Chagoya A et al. ( 2023 ) . Multi-ancestry genome-wide study in &gt;2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications .

Repetto L, Chen J, Yang Z, Zhai R, Timmers P, Li T, Twait E, May-Wilson S et al. ( 2023 ) . Unraveling Neuro-Proteogenomic Landscape and Therapeutic Implications for Human Behaviors and Psychiatric Disorders .

Xu Y, Ritchie SC, Liang Y, Timmers PRHJ, Pietzner M, Lannelongue L, Lambert SA, Tahir UA et al. ( 2023 ) . An atlas of genetic scores to predict multi-omic traits . Nature vol. 616 , ( 7955 ) 123 - 131 .

Koprulu M, Carrasco-Zanini J, Wheeler E, Lockhart S, Kerrison ND, Wareham NJ, Pietzner M, Langenberg C ( 2023 ) . Author Correction: Proteogenomic links to human metabolic diseases . Nature Metabolism vol. 5 , ( 4 ) 710 - 710 .

Steinfeldt J, Wild B, Buergel T, Pietzner M, Upmeier zu Belzen J, Vauvelle A, Hegselmann S, Denaxas S et al. ( 2023 ) . Medical history predicts phenome-wide disease onset and enables the rapid response to emerging health threats .

Carland C, Png G, Malarstig A, Kho PF, Gustafsson S, Michaelsson K, Lind L, Tsafantakis E et al. ( 2023 ) . Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases .

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( 2012 ) . Physical activity reduces the risk of incident type 2 diabetes in general and in abdominally lean and obese men and women: the EPIC–InterAct Study . Diabetologia vol. 55 , ( 7 ) 1944 - 1952 .

( 2012 ) . Circulating 25-hydroxyvitamin D concentration and the risk of type 2 diabetes: results from the European Prospective Investigation into Cancer (EPIC)-Norfolk cohort and updated meta-analysis of prospective studies . Diabetologia vol. 55 , ( 8 ) 2173 - 2182 .

( 2012 ) . No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels . Diabetes vol. 61 , ( 5 ) 1291 - 1296 .

( 2012 ) . Circadian Gene Variants and Susceptibility to Type 2 Diabetes: A Pilot Study . PLoS ONE vol. 7 , ( 4 ) e32670 - e32670 .

( 2012 ) . Genetic determinants of glucose homeostasis . Best Practice &amp; Research Clinical Endocrinology &amp; Metabolism vol. 26 , ( 2 ) 159 - 170 .

( 2012 ) . Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals . PLoS Genetics vol. 8 , ( 3 ) e1002607 - e1002607 .

Imamura M, Maeda S, Yamauchi T, Hara K, Yasuda K, Morizono T, Takahashi A, Horikoshi M et al. ( 2012 ) . A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations . Human Molecular Genetics vol. 21 , ( 13 ) 3042 - 3049 .

Stahl EA, Wegmann D, Trynka G, Gutierrez-Achury J, Do R, Voight BF, Kraft P, Chen R et al. ( 2012 ) . Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis . Nature Genetics vol. 44 , ( 5 ) 483 - 489 .

( 2012 ) . Evaluation of common genetic variants identified by GWAS for early onset and morbid obesity in population-based samples . International Journal of Obesity vol. 37 , ( 2 ) 191 - 196 .

( 2012 ) . P128 Identification de nouveaux polymorphismes génétiques associés au risque de diabète de type 2 chez les obèses et non obèses européens . Diabetes &amp; Metabolism . vol. 38 , A61 - A62 .

( 2012 ) . The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis . The Lancet vol. 379 , ( 9822 ) 1214 - 1224 .

Demirkan A, van Duijn CM, Ugocsai P, Isaacs A, Pramstaller PP, Liebisch G, Wilson JF, Johansson Å et al. ( 2012 ) . Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations . PLoS Genetics vol. 8 , ( 2 ) e1002490 - e1002490 .

( 2012 ) . Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes . Nature Genetics vol. 44 , ( 3 ) 297 - 301 .

( 2012 ) . Low-Frequency Variants in <i>HMGA1</i> Are Not Associated With Type 2 Diabetes Risk . Diabetes vol. 61 , ( 2 ) 524 - 530 .

( 2012 ) . The association between prior infection with five serotypes of Coxsackievirus B and incident type 2 diabetes mellitus in the EPIC-Norfolk study . Diabetologia vol. 55 , ( 4 ) 967 - 970 .

( 2012 ) . A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans . PLoS ONE vol. 7 , ( 1 ) e29202 - e29202 .

Dimas AS, Gomes VI, Knowles J, Maegi R, Barker A, Hivert M-F, Benazzo A, Rybin D et al. ( 2012 ) . Impact of Type 2 Diabetes Susceptibility Loci on Variation in Physiologic Glycaemic Traits in Non-Diabetic Individuals . CIRCULATION . vol. 126 ,

( 2012 ) . Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways . NATURE GENETICS vol. 44 , ( 9 ) 991 - + .

( 2012 ) . Mendelian Randomization Studies to Understand the Role for Reduced Adiponectin Levels in Insulin Resistance or Type 2 Diabetes . DIABETES . vol. 61 , A395 - A395 .

Langenberg C, Ye Z, Gillson C, Plotka M, Khaw K-T, Poulton J, Wareham NJ ( 2012 ) . The association of the mitochondrial DNA 16184-16193 poly-C variant with type 2 diabetes . DIABETOLOGIA . vol. 55 , S77 - S78 .

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( 2011 ) . New gene functions in megakaryopoiesis and platelet formation . Nature vol. 480 , ( 7376 ) 201 - 208 .

( 2011 ) . Validity of a short questionnaire to assess physical activity in 10 European countries . European Journal of Epidemiology vol. 27 , ( 1 ) 15 - 25 .

( 2011 ) . Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1 . American Journal of Human Genetics vol. 89 , ( 5 ) 619 - 627 .

Bown MJ, Jones GT, Harrison SC, Wright BJ, Bumpstead S, Baas AF, Gretarsdottir S, Badger SA et al. ( 2011 ) . Abdominal Aortic Aneurysm Is Associated with a Variant in Low-Density Lipoprotein Receptor-Related Protein 1 . The American Journal of Human Genetics vol. 89 , ( 5 ) 619 - 627 .

Chambers JC, Zhang WH, Sehmi J, Li XZ, Wass MN, Van der Harst P, Holm H, Sanna S et al. ( 2011 ) . Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma . NAT GENET vol. 43 , ( 11 ) 1131 - U129 .

( 2011 ) . Mendelian Randomization Study of B-Type Natriuretic Peptide and Type 2 Diabetes: Evidence of Causal Association from Population Studies . PLoS Medicine vol. 8 , ( 10 ) e1001112 - e1001112 .

( 2011 ) . Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes . Diabetes vol. 60 , ( 10 ) 2624 - 2634 .

( 2011 ) . The Lin28/let-7 Axis Regulates Glucose Metabolism . Cell vol. 147 , ( 1 ) 81 - 94 .

( 2011 ) . Total Zinc Intake May Modify the Glucose-Raising Effect of a Zinc Transporter (<i>SLC30A8</i>) Variant . Diabetes vol. 60 , ( 9 ) 2407 - 2416 .

( 2011 ) . Mediterranean Diet and Type 2 Diabetes Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC) Study . Diabetes Care vol. 34 , ( 9 ) 1913 - 1918 .

( 2011 ) . Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study . Diabetologia vol. 54 , ( 9 ) 2272 - 2282 .

( 2011 ) . No evidence for a causal link between uric acid and type 2 diabetes: a Mendelian randomisation approach . Diabetologia vol. 54 , ( 10 ) 2561 - 2569 .

( 2011 ) . Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile . Nature Genetics vol. 43 , ( 8 ) 753 - 760 .

( 2011 ) . Individual and cumulative effect of type 2 diabetes genetic susceptibility variants on risk of coronary heart disease . Diabetologia vol. 54 , ( 9 ) 2283 - 2287 .

( 2011 ) . Association of Genetic Loci With Glucose Levels in Childhood and Adolescence . Diabetes vol. 60 , ( 6 ) 1805 - 1812 .

( 2011 ) . Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes . Nature Genetics vol. 43 , ( 6 ) 561 - 564 .

( 2011 ) . Associations of Common Genetic Variants With Age-Related Changes in Fasting and Postload Glucose . Diabetes vol. 60 , ( 5 ) 1617 - 1623 .

( 2011 ) . An amino acid profile to predict diabetes? . Nature Medicine vol. 17 , ( 4 ) 418 - 420 .

( 2011 ) . Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis (vol 42, pg 579, 2010) . NAT GENET vol. 43 , ( 4 ) 388 - 388 .

Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, Gudnason V, Eiriksdottir G et al. ( 2011 ) . Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits . PLoS Genetics vol. 7 , ( 3 ) e1001324 - e1001324 .

( 2011 ) . Common variants at 10 genomic loci influence hemoglobin A1C levels via glycemic and nonglycemic pathways (Diabetes (2010) 59, (3229-3239)) . Diabetes vol. 60 , ( 3 )

( 2011 ) . Mendelian Randomization Studies Do Not Support a Role for Raised Circulating Triglyceride Levels Influencing Type 2 Diabetes, Glucose Levels, or Insulin Resistance . Diabetes vol. 60 , ( 3 ) 1008 - 1018 .

( 2011 ) . Erratum . Diabetes Care vol. 34 , ( 3 ) 785 - 786 .

( 2011 ) . Genetic predisposition to obesity leads to increased risk of type 2 diabetes . Diabetologia vol. 54 , ( 4 ) 776 - 782 .

Adler A, Langenberg C, Sims M, Wareham NJ ( 2011 ) . Are population-based carriers of a mutation associated with cystic fibrosis patients more likely to have diabetes? . DIABETOLOGIA . vol. 54 , S154 - S154 .

Langenberg C, Wareham NJ ( 2011 ) . Design and Cohort Description of the InterAct Project: An Examination of the Interaction of Genetic and Lifestyle Factors on the Incidence of Type 2 Diabetes in the EPIC Study . DIABETES . vol. 60 , A367 - A367 .

Scott RA, Manning AK, Hivert M-F, Bouatia-Naji N, Grimsby J, Liu C-T, Chen H, Bielak LF et al. ( 2011 ) . Genome-wide joint meta-analysis of SNP by BMI interaction on fasting insulin: a MAGIC study . DIABETOLOGIA . vol. 54 , S76 - S76 .

Prokopenko I, Lagou V, Scott RA, Wheeler E, Welch R, Luan J, Maegi R, Teslovich TM et al. ( 2011 ) . Large-scale replication using \Metabochip\ array identifies additional genetic loci influencing glycaemic traits . DIABETOLOGIA . vol. 54 , S47 - S48 .

Langenberg C, Sharp SJ, Wareham NJ ( 2011 ) . Long-term risk of type 2 diabetes and measures of overall and regional obesity: the European InterAct study . DIABETOLOGIA . vol. 54 , S118 - S119 .

Forouhi NG, Ye Z, Rickard AP, Khaw K-T, Luben R, Langenberg C, Wareham NJ ( 2011 ) . The association and causal inference between circulating 25-hydroxy vitamin D concentration and the risk of type 2 diabetes . DIABETOLOGIA . vol. 54 , S75 - S75 .

( 2010 ) . Differential White Blood Cell Count and Type 2 Diabetes: Systematic Review and Meta-Analysis of Cross-Sectional and Prospective Studies . PLoS ONE vol. 5 , ( 10 ) e13405 - e13405 .

( 2010 ) . Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways . Diabetes vol. 59 , ( 12 ) 3229 - 3239 .

( 2010 ) . Interactions of Dietary Whole-Grain Intake With Fasting Glucose– and Insulin-Related Genetic Loci in Individuals of European Descent . Diabetes Care vol. 33 , ( 12 ) 2684 - 2691 .

( 2010 ) . Biological, clinical and population relevance of 95 loci for blood lipids . NATURE vol. 466 , ( 7307 ) 707 - 713 .

( 2010 ) . Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis . NAT GENET vol. 42 , ( 7 ) 579 - U155 .

( 2010 ) . Genetic Markers of Adult Obesity Risk Are Associated with Greater Early Infancy Weight Gain and Growth . PLoS Medicine vol. 7 , ( 5 ) e1000284 - e1000284 .

( 2010 ) . Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk . Nature Genetics vol. 42 , ( 5 ) 464 - 464 .

( 2010 ) . MTNR1B rs10830963 is associated with fasting plasma glucose, HbA1Cand impaired beta-cell function in Chinese Hans from Shanghai . BMC Medical Genetics vol. 11 , ( 1 ) Article 59 ,

Dash S, Langenberg C, Fawcett KA, Semple RK, Romeo S, Sharp S, Sano H, Lienhard GE et al. ( 2010 ) . Analysis of TBC1D4 in patients with severe insulin resistance . Diabetologia vol. 53 , ( 6 ) 1239 - 1242 .

Bouatia-Naji N, Saxena R, Hivert MF, Langenberg C, Tanaka T, Pankow J, Vollenweider P, Lyssenko V et al. ( 2010 ) . O10 Une méta-analyse GWA de la glycémie après 2 h d’HGPO révèle que GIPR est associé avec la sécrétion de l’insuline en réponse au glucose et que ADCY5 est un nouveau gène de susceptibilité au diabète de type 2 . Diabetes &amp; Metabolism vol. 36 , A3 - A3 .

( 2010 ) . Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans . Diabetes vol. 59 , ( 5 ) 1266 - 1275 .

( 2010 ) . Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge . NAT GENET vol. 42 , ( 2 ) 142 - U75 .

( 2010 ) . New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk . NAT GENET vol. 42 , ( 2 ) 105 - U32 .

Langenberg C, Jensen AC, Barker A, Brunner EJ, Hingorani AD, Kumari M, Kivimaeki M, Wareham NJ et al. ( 2010 ) . Age-dependent genetic effects on post-load glucose during 18 years of follow-up of the Whitehall II Cohort . DIABETOLOGIA . vol. 53 , S122 - S123 .

Nettleton JA, McKeown NM, Kanoni S, Lemaitre RN, Hivert M-F, Ngwa J, van Rooij FJA, Sonestedt E et al. ( 2010 ) . Interactions of Dietary Whole-Grain Intake With Fasting Glucose- and Insulin-Related Genetic Loci in Individuals of European Descent A meta-analysis of 14 cohort studies . DIABETES CARE vol. 33 , ( 12 ) 2684 - 2691 .

( 2009 ) . Ghrelin and Bone: Is There an Association in Older Adults?: The Rancho Bernardo Study . Journal of Bone and Mineral Research vol. 21 , ( 5 ) 752 - 757 .

( 2009 ) . A Genome-Wide Association Study Reveals Variants in ARL15 that Influence Adiponectin Levels . PLOS GENET vol. 5 , ( 12 ) Article e1000768 ,

( 2009 ) . Parental origin of sequence variants associated with complex diseases . Nature vol. 462 , ( 7275 ) 868 - 874 .

( 2009 ) . Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes . Human Molecular Genetics vol. 19 , ( 3 ) 535 - 544 .

( 2009 ) . Common Genetic Determinants of Glucose Homeostasis in Healthy Children . Diabetes vol. 58 , ( 12 ) 2939 - 2945 .

( 2009 ) . Underlying Genetic Models of Inheritance in Established Type 2 Diabetes Associations . American Journal of Epidemiology vol. 170 , ( 5 ) 537 - 545 .

( 2009 ) . A truncation mutation in\n <i>TBC1D4</i>\n in a family with acanthosis nigricans and postprandial hyperinsulinemia . Proceedings of the National Academy of Sciences vol. 106 , ( 23 ) 9350 - 9355 .

Langenberg C, Pascoe L, Mari A, Tura A, Laakso M, Frayling TM, Barroso I, Loos RJF et al. ( 2009 ) . Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response . Diabetologia vol. 52 , ( 8 ) 1537 - 1542 .

Wheeler E, Soranzo N, Sanna S, Gieger C, Radke D, Dupuis J, Stolerman E, Bouatia-Naji N et al. ( 2009 ) . A Large Genome-wide Association Study of Glycated Hemoglobin Identifies Ten Common Variants not Mediated Through BMI . GENETIC EPIDEMIOLOGY . vol. 33 , 758 - 759 .

Elks C, Loos RJF, Davey-Smith G, Dunger D, Wareham N, Ong K, Sharp S, Langenberg C et al. ( 2009 ) . Childhood Phenotypes Related to Adult Obesity: The Application of Genetic Risk Variants . OBESITY . vol. 17 , S80 - S81 .

Langenberg C, Saxena R, Hivert M-F, Tanaka T, Pankow JS, Lyssenko V, Boutia-Naji N, Kao WHL et al. ( 2009 ) . Genome-wide meta-analysis identifies novel genetic loci associated with OGTT-induced post-challenge glucose . DIABETOLOGIA . vol. 52 , S37 - S38 .

( 2009 ) . Mendelian Randomization Studies of the Role of Biomarkers in Type 2 Diabetes . DIABETES . vol. 58 , A311 - A311 .

Saxena R, Hivert M-F, Dupuis J, Langenberg C, Kao WL, Tanaka T, Jackson AU, Pankow JS et al. ( 2009 ) . Meta-Analyses of Genome-Wide Association Studies for 2-Hour Glucose Levels during an Oral Glucose Tolerance Test Identify Novel Genetic Loci . DIABETES . vol. 58 , A48 - A48 .

Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL et al. ( 2009 ) . Novel Genetic Loci Implicated in Fasting Glucose Homeostasis and Their Impact on Related Metabolic Traits . GENETIC EPIDEMIOLOGY . vol. 33 , 788 - 788 .

Prokopenko I, Dupuis J, Langenberg C, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL et al. ( 2009 ) . Novel genetic loci implicated in fasting glucose homeostasis and their impact on related metabolic traits . DIABETOLOGIA . vol. 52 , S38 - S38 .

( 2009 ) . Variants in MTNR1B influence fasting glucose levels . NAT GENET vol. 41 , ( 1 ) 77 - 81 .

Prokopenko I, Hottenga JJ, Aulchenko YS, Thorleifsson G, Dupuis J, Florez JC, Go MJ, Jackson AU et al. ( 2009 ) . Variants in the DGKB Gene Influence Fasting Glucose Levels in Populations of European and East Asian Descent . DIABETES . vol. 58 , A48 - A48 .

( 2008 ) . Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes . NAT GENET vol. 40 , ( 5 ) 638 - 645 .

( 2008 ) . Usefulness of Microalbuminuria Versus the Metabolic Syndrome as a Predictor of Cardiovascular Disease in Women and Men &gt;40 Years of Age (from the Rancho Bernardo Study) . The American Journal of Cardiology vol. 101 , ( 9 ) 1275 - 1280 .

( 2008 ) . Prevalence of Angina in Women Versus Men . Circulation vol. 117 , ( 12 ) 1526 - 1536 .

Batty GD, Gale CR, Mortensen LH, Langenberg C, Shipley MJ, Deary IJ ( 2008 ) . Pre-morbid intelligence, the metabolic syndrome and mortality: the Vietnam Experience Study . Diabetologia vol. 51 , ( 3 ) 436 - 443 .

Langenberg C, Loos RJF, Brage S, Sardinha LB, Andersen LB, Ekelund U, Wareham NJ ( 2008 ) . Novel type 2 diabetes susceptibility loci and measures of glycaemic control in a population based study of healthy children . DIABETOLOGIA . vol. 51 , S31 - S31 .

( 2007 ) . Diabetes and Coronary Heart Disease in Filipino-American Women . Diabetes Care vol. 30 , ( 3 ) 535 - 541 .

( 2007 ) . Life course body size and lipid levels at 53 years in a British birth cohort . Journal of Epidemiology &amp; Community Health vol. 61 , ( 3 ) 215 - 220 .

( 2006 ) . Household Wealth and the Metabolic Syndrome in the Whitehall II Study . Diabetes Care vol. 29 , ( 12 ) 2694 - 2700 .

( 2006 ) . Social Circumstances and Education: Life Course Origins of Social Inequalities in Metabolic Risk in a Prospective National Birth Cohort . American Journal of Public Health vol. 96 , ( 12 ) 2216 - 2221 .

( 2006 ) . Adult height and lung function as markers of life course exposures: Associations with risk factors and cause-specific mortality . European Journal of Epidemiology vol. 21 , ( 11 ) 795 - 801 .

( 2006 ) . Association of Adiponectin with Coronary Heart Disease and Mortality: The Rancho Bernardo Study . American Journal of Epidemiology vol. 165 , ( 2 ) 164 - 174 .

( 2006 ) . Birth weight, components of height and coronary heart disease: evidence from the Whitehall II study . International Journal of Epidemiology vol. 35 , ( 6 ) 1532 - 1542 .

( 2006 ) . Cardiovascular Death and the Metabolic Syndrome . Diabetes Care vol. 29 , ( 6 ) 1363 - 1369 .

Langenberg C, Barrett-Connor E, Damant J, Hemingway H ( 2006 ) . Sex differences in angina pectoris: meta-analysis of international variations in 53 studies in 23 countries . European Journal of Cardiovascular Prevention &amp; Rehabilitation vol. 13 , ( Supplement 1 ) S31 - S31 .

Batty GD, Shipley MJ, Langenberg C, Marmot MG, Davey Smith G ( 2006 ) . Adult height in relation to mortality from 14 cancer sites in men in London (UK): evidence from the original Whitehall study . Annals of Oncology vol. 17 , ( 1 ) 157 - 166 .

Jassal SK, Langenberg C, Bergstrom J, von Muhlen D, Barrett-Connor E ( 2006 ) . Albuminuria improves prediction of cardiovascular disease mortality in older women with or without metabolic syndrome . CIRCULATION . vol. 113 , E344 - E345 .

Langenberg C, Allison M, Wong N, Detrano R, Shea S, Carr J, Criqui M ( 2006 ) . Aortic and coronary calcium in diabetic and nondiabetic men and women in the Multi-Ethnic Study of Atherosclerosis (MESA) . CIRCULATION . vol. 113 , E358 - E358 .

Langenberg C, Bergstrom J, Von Mühlen D, Barrett-Connor E ( 2006 ) . Metabolic syndrome improves the prediction of coronary heart disease mortality in diabetes . CIRCULATION . vol. 113 , E343 - E343 .

Bergstrom J, Langenberg C, von Muhlen D, Barrett-Connor E ( 2006 ) . Novel risk factors do not improve prediction of cardiovascular mortality: Evidence from the Rancho Bernardo Study . CIRCULATION . vol. 113 , E334 - E334 .

( 2005 ) . Ghrelin and the Metabolic Syndrome in Older Adults . The Journal of Clinical Endocrinology &amp; Metabolism vol. 90 , ( 12 ) 6448 - 6453 .

( 2005 ) . Ghrelin, Adiponectin, and Leptin Do Not Predict Long-term Changes in Weight and Body Mass Index in Older Adults: Longitudinal Analysis of the Rancho Bernardo Cohort . American Journal of Epidemiology vol. 162 , ( 12 ) 1189 - 1197 .

Perel P, Langenberg C, Ferrie J, Moser K, Brunner E, Marmot M ( 2005 ) . 211-S: Household Wealth and the Metabolic Syndrome in the Whitehall II Cohort . American Journal of Epidemiology vol. 161 , ( Supplement_1 ) S53 - S53 .

( 2005 ) . Department of Error . The Lancet vol. 365 , ( 9471 ) 1620 - 1620 .

( 2005 ) . Influence of short stature on the change in pulse pressure, systolic and diastolic blood pressure from age 36 to 53 years: an analysis using multilevel models . International Journal of Epidemiology vol. 34 , ( 4 ) 905 - 913 .

( 2005 ) . Adult Socioeconomic Position and the Association Between Height and Coronary Heart Disease Mortality: Findings From 33 Years of Follow-Up in the Whitehall Study . American Journal of Public Health vol. 95 , ( 4 ) 628 - 632 .

Kuh D, Langenberg C, Hardy R, Kok H, Cooper R, Butterworth S, Wadsworth MEJ ( 2005 ) . Cardiovascular risk at age 53 years in relation to the menopause transition and use of hormone replacement therapy: a prospective British birth cohort study . BJOG: An International Journal of Obstetrics &amp; Gynaecology vol. 112 , ( 4 ) 476 - 485 .

Hardy R, Kuh D, Langenberg C, Wadsworth MEJ ( 2005 ) . Birthweight, childhood social class, and change in adult blood pressure in the 1946 British birth cohort (vol 362, pg 1178, 2003) . LANCET vol. 365 , ( 9471 ) 1620 - 1620 .

Langenberg C, Bergstrom J, Barrett-Connor E ( 2005 ) . Cardiovascular death and the metabolic syndrome: Role of inflammatory cytokines and adiposity signaling hormones . CIRCULATION . vol. 112 , U889 - U889 .

Langenberg C, Bergstrom J, Laughlin GA, Barrett-Connor E ( 2005 ) . Hormonal signals of weight homeostasis and 18-year weight change in older adults: Longitudinal analysis of the Rancho Bernardo cohort . CIRCULATION . vol. 111 , E205 - E205 .

( 2004 ) . Birth Weight and Lipids in a National Birth Cohort Study . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 24 , ( 3 ) 588 - 594 .

( 2004 ) . Birthweight, childhood growth, and blood pressure at 43 years in a British birth cohort . International Journal of Epidemiology vol. 33 , ( 1 ) 121 - 129 .

( 2003 ) . Commentary: The association between height growth and cholesterol levels during puberty: implications for adult health . International Journal of Epidemiology vol. 32 , ( 6 ) 1110 - 1111 .

Wadsworth MEJ, Butterworth SL, Hardy RJ, Kuh DJ, Richards M, Langenberg C, Hilder WS, Connor M ( 2003 ) . The life course prospective design: an example of benefits and problems associated with study longevity . Social Science &amp; Medicine vol. 57 , ( 11 ) 2193 - 2205 .

( 2003 ) . Birthweight, childhood social class, and change in adult blood pressure in the 1946 British birth cohort . The Lancet vol. 362 , ( 9391 ) 1178 - 1183 .

Langenberg C ( 2003 ) . Central and total obesity in middle aged men and women in relation to lifetime socioeconomic status: evidence from a national birth cohort . Journal of Epidemiology &amp; Community Health vol. 57 , ( 10 ) 816 - 822 .

( 2003 ) . Commentary: Disentangling the association between short height and cardiovascular risk—genes or environment? . International Journal of Epidemiology vol. 32 , ( 4 ) 614 - 616 .

( 2003 ) . Influence of height, leg and trunk length on pulse pressure, systolic and diastolic blood pressure . Journal of Hypertension vol. 21 , ( 3 ) 537 - 543 .

( 2003 ) . Human organic anion transporter 3 (hOAT3) in human adrenocortical cells transports cortisol . FASEB JOURNAL . vol. 17 , A477 - A477 .

( 2002 ) . Mortality in adults aged 26-54 years related to socioeconomic conditions in childhood and adulthood: post war birth cohort study . BMJ vol. 325 , ( 7372 ) 1076 - 1080 .

Pritsche L, Donner-Banzhoff N, Druck G, Kunz R, Langenberg C, Lelgemann M, Pientka L, Von Maxen A et al. ( 2001 ) . EbM-courses for hospital and practise settings - Current models in Germany . Zeitschrift Fur Arztliche Fortbildung Und Qualitatssicherung vol. 95 , ( 4 ) 297 - 298 .

Helou A, Perleth M, Lühmann D, Langenberg C, Busse R ( 2001 ) . Evidence-based medicine: What kind of competencies should medical education provide? . Medizinische Ausbildung . vol. 18 , 31 - 37 .

Raspe H, Langenberg C ( 1999 ) . Final and causal foundations of medical practice--two achievements of evidence-based medicine . Zeitschrift Fur Arztliche Fortbildung Und Qualitatssicherung in Zusammenarbeit Mit Der Kaiserin Friedrich Stiftung Fur Das Arztliche Fortbildungswesen vol. 93 , ( 4 )

. Coding Variant In&amp;nbsp; &lt;i&gt;LEP&lt;/i&gt;&amp;nbsp;Associated with Lower Leptin Concentrations Implicates Leptin in the Regulation of Early Adiposity .

. Elucidating the genetic architecture underlying IGF1 levels and its impact on genomic instability and cancer risk .

. Exome Sequencing Identifies Multiple Genes and Gene-Sets Contributing to Severe Childhood Obesity .

Mehta N, Mytton O, Mullins E, Fowler T, Falconer C, Murphy O, Langenberg C, Jayatunga W et al. . SARS-CoV-2 (COVID-19): What Do We Know About Children? A Systematic Review .

. Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation .