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Research

Publications: DR Sarah Morgan

( 2025 ) . Molecular hallmarks of cognitive resilience and resistance in Alzheimer's disease: Insights from excitatory and inhibitory neurons . Alzheimer's & Dementia vol. 21 , ( Suppl 1 ) e096285 - e096285 .
( 2025 ) . Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheimer’s disease . Molecular Neurodegeneration vol. 20 , ( 1 )
( 2025 ) . Redefining ALS: Large-scale proteomic profiling reveals a prolonged pre-diagnostic phase with immune, muscular, metabolic, and brain involvement . rs.3.rs - 7452736 .
( 2025 ) . Redefining ALS: Large-scale proteomic profiling reveals a prolonged pre-diagnostic phase with immune, muscular, metabolic, and brain involvement .
( 2025 ) . A PKCη missense mutation enhances Golgi-localized signaling and is associated with recessively inherited familial Alzheimer’s disease . Science Signaling vol. 18 , ( 893 ) eadv0970 - eadv0970 .
Castanho I, Yeganeh PN, Boix CA, Mathys H, Prokopenko D, White B, Morgan S, Lange C et al. ( 2025 ) . Deciphering the molecular and cellular underpinnings of cognitive resilience in Alzheimer’s disease . Alzheimer's & Dementia vol. 20 , ( Suppl 1 )
Naderi Yeganeh P, Teo YY, Karagkouni D, Pita-Juárez Y, Morgan SL, Slack FJ, Vlachos IS, Hide WA ( 2023 ) . PanomiR: a systems biology framework for analysis of multi-pathway targeting by miRNAs . Briefings in Bioinformatics vol. 24 , ( 6 )
Morgan SL, Naderi P, Koler K, Pita-Juarez Y, Prokopenko D, Vlachos IS, Tanzi RE, Bertram L et al. ( 2022 ) . Most Pathways Can Be Related to the Pathogenesis of Alzheimer’s Disease . Frontiers in Aging Neuroscience vol. 14 ,
Prokopenko D, Morgan SL, Lange C, Hide W, Bertram L, Tanzi RE ( 2022 ) . Reply to Neupane et al.: Replication study of AD‐associated rare variants . Alzheimer's & Dementia vol. 18 , ( 4 ) 863 - 864 .
Garton FC, Benyamin B, Zhao Q, Liu Z, Gratten J, Henders AK, Zhang Z, Edson J et al. ( 2017 ) . Whole exome sequencing and DNA methylation analysis in a clinical amyotrophic lateral sclerosis cohort . Molecular Genetics & Genomic Medicine vol. 5 , ( 4 ) 418 - 428 .
Morgan S, Shatunov A, Sproviero W, Jones AR, Shoai M, Hughes D, Al Khleifat A, Malaspina A et al. ( 2017 ) . A comprehensive analysis of rare genetic variation in amyotrophic lateral sclerosis in the UK . Brain vol. 140 , ( 6 ) 1611 - 1618 .
Abdelkarim S, Morgan S, Plagnol V, Lu C-H, Adamson G, Howard R, Malaspina A, Orrell R et al. ( 2015 ) . CHCHD10 Pro34Ser is not a highly penetrant pathogenic variant for amyotrophic lateral sclerosis and frontotemporal dementia . Brain vol. 139 , ( 2 ) e9 - e9 .
Morgan S, Shoai M, Fratta P, Sidle K, Orrell R, Sweeney MG, Shatunov A, Sproviero W et al. ( 2014 ) . Investigation of next-generation sequencing technologies as a diagnostic tool for amyotrophic lateral sclerosis . Neurobiology of Aging vol. 36 , ( 3 ) 1600.e5 - 1600.e8 .
Johnson JO, Pioro EP, Boehringer A, Chia R, Feit H, Renton AE, Pliner HA, Abramzon Y et al. ( 2014 ) . Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis . Nature Neuroscience vol. 17 , ( 5 ) 664 - 666 .
Homann J, Smith AG, Morgan S, Frick EA, Liu F, Viallon V, Maurya R, Korologou-Linden R et al. . Large-scale plasma proteomics uncovers preclinical molecular signatures of Parkinson’s disease and overlap with other neurodegenerative disorders .
Castanho I, Yeganeh PN, Boix CA, Morgan SL, Mathys H, Prokopenko D, White B, Soto LM et al. . Molecular hallmarks of excitatory and inhibitory neuronal resilience and resistance to Alzheimer’s disease .
Yeganeh PN, Teo YY, Karagkouni D, Pita-Juárez Y, Morgan SL, Slack FJ, Vlachos IS, Hide WA . PanomiR: A systems biology framework for analysis of multi-pathway targeting by miRNAs .
Gauron MC, Prokopenko D, Lee S, Wolfe SA, Hecker J, Willett J, Waqas M, Lordén G et al. . Protein kinase C eta enhances Golgi-localized signaling and is associated with Alzheimer’s disease using a recessive mode of inheritance .