Publications: DR Emma Chambers

( 2025 ) . Metabolic dysfunction over a life course key to healthy ageing inequality . Aging Clinical and Experimental Research vol. 37 , ( 1 ) Article 191 ,

( 2025 ) . Age-associated inflammatory monocytes are increased in menopausal females and reversed by Hormone Replacement Therapy .

( 2025 ) . Estrogen influences class-switched memory B cell frequency only in humans with two X chromosomes . Journal of Experimental Medicine vol. 222 , ( 4 ) Article e20241253 ,

( 2025 ) . Replicating Dynamic Immune Responses at Single‐Cell Resolution within a Microfluidic Human Skin Equivalent . Advanced Science vol. 12 , ( 10 ) Article 2415717 ,

( 2025 ) . Immunotherapeutic targeting of aging‐associated isoDGR motif in chronic lung inflammation . Aging Cell vol. 24 , ( 4 ) Article e14425 ,

( 2024 ) . Replicating dynamic immune responses at single-cell resolution within a microfluidic human skin equivalent .

( 2024 ) . Multiple outcomes of the germline <scp>p16^INK4a</scp> mutation affecting senescence and immunity in human skin . Aging Cell vol. 24 , ( 2 ) Article e14373 ,

( 2024 ) . Immunogenicity of biologics used in the treatment of asthma . Human Antibodies vol. 32 , ( 3 ) 121 - 128 .

( 2024 ) . Influence of individuals’ determinants including vaccine type on cellular and humoral responses to SARS-CoV-2 vaccination . npj Vaccines vol. 9 , ( 1 ) Article 87 ,

( 2024 ) . Vitamin <scp>D₃</scp> inhibits p38 <scp>MAPK</scp> and senescence‐associated inflammatory mediator secretion by senescent fibroblasts that impacts immune responses during ageing . Aging Cell vol. 23 , ( 4 ) Article e14093 ,

( 2023 ) . Influence of age, sex, body habitus, vaccine type and anti-S serostatus on cellular and humoral responses to SARS-CoV-2 vaccination .

( 2023 ) . Age-linked lung pathology is reduced by immunotherapeutic targeting of isoDGR protein damage .

( 2022 ) . Vitamin D Supplementation Does Not Influence SARS-CoV-2 Vaccine Efficacy or Immunogenicity: Sub-Studies Nested within the CORONAVIT Randomised Controlled Trial . Nutrients vol. 14 , ( 18 ) 3821 - 3821 .

( 2022 ) . Correlation Between Postvaccination Anti-Spike Antibody Titers and Protection Against Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Population-Based Longitudinal Study . The Journal of Infectious Diseases vol. 226 , ( 11 ) 1903 - 1908 .

( 2022 ) . Influence of vitamin D supplementation on SARS-CoV-2 vaccine efficacy and immunogenicity .

( 2022 ) . Correlation between post-vaccination titres of combined IgG, IgA, and IgM anti-Spike antibodies and protection against breakthrough SARS-CoV-2 infection: a population-based longitudinal study (COVIDENCE UK) .

( 2021 ) . Cellular senescence as a possible link between prostate diseases of the ageing male . Nature Reviews Urology vol. 18 , ( 10 ) 597 - 610 .

( 2021 ) . Exploring the Evidence for an Immunomodulatory Role of Vitamin D in Juvenile and Adult Rheumatic Disease . Frontiers in Immunology vol. 11 , Article 616483 ,

( 2021 ) . The impact of ageing on monocytes and macrophages . Immunology Letters vol. 230 , 1 - 10 .

( 2021 ) . Recruitment of inflammatory monocytes by senescent fibroblasts inhibits antigen-specific tissue immunity during human aging . Nature Aging vol. 1 , ( 1 ) 101 - 113 .

( 2020 ) . Vitamin D3 replacement enhances antigen-specific immunity in older adults . Immunotherapy Advances vol. 1 , ( 1 ) Article ltaa008 ,

( 2020 ) . Reply . vol. 146 , is. 4 , pp. 922 - 923 . Elsevier BV

( 2020 ) . Can blocking inflammation enhance immunity during aging? . Journal of Allergy and Clinical Immunology vol. 145 , ( 5 ) 1323 - 1331 .

( 2020 ) . Monocyte-derived Prostaglandin E2 inhibits antigen-specific cutaneous immunity during ageing .

( 2020 ) . Sestrins induce natural killer function in senescent-like CD8+ T cells . Nature Immunology vol. 21 , ( 6 ) 684 - 694 .

( 2019 ) . Skin barrier immunity and ageing . Immunology vol. 160 , ( 2 ) 116 - 125 .

( 2019 ) . Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition . Nature Communications vol. 10 , ( 1 ) Article 2387 ,

( 2019 ) . Circulating Senescent T Cells Are Linked to Systemic Inflammation and Lesion Size During Human Cutaneous Leishmaniasis . Frontiers in Immunology vol. 9 , Article 3001 ,

( 2018 ) . Impact of Zostavax Vaccination on T-Cell Accumulation and Cutaneous Gene Expression in the Skin of Older Humans After Varicella Zoster Virus Antigen–Specific Challenge . The Journal of Infectious Diseases vol. 218 , ( suppl_2 ) S88 - S98 .

( 2018 ) . Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase–induced inflammation . Journal of Allergy and Clinical Immunology vol. 142 , ( 3 ) 844 - 856 .

( 2017 ) . Dendritic cell phenotype in severe asthma reflects clinical responsiveness to glucocorticoids . Clinical &amp; Experimental Allergy vol. 48 , ( 1 ) 13 - 22 .

( 2017 ) . Human <scp>CD</scp>8⁺<scp>EMRA</scp> T cells display a senescence‐associated secretory phenotype regulated by p38 <scp>MAPK</scp> . Aging Cell vol. 17 , ( 1 ) Article e12675 ,

( 2016 ) . Inflammatory response to saline in the skin of older individuals is driven in part by macrophages . BRITISH JOURNAL OF DERMATOLOGY . vol. 175 , 38 - 38 .

( 2015 ) . 1<i>α</i>,25‐dihydroxyvitamin D3 acts via transforming growth factor‐<i>β</i> to up‐regulate expression of immunosuppressive CD73 on human CD4⁺ Foxp3^– T cells . Immunology vol. 146 , ( 3 ) 423 - 431 .

( 2015 ) . Distinct endotypes of steroid-resistant asthma characterized by IL-17Ahigh and IFN-γhigh immunophenotypes: Potential benefits of calcitriol . Journal of Allergy and Clinical Immunology vol. 136 , ( 3 ) 628 - 637.e4 .

( 2014 ) . Vitamin D Influences Asthmatic Pathology through Its Action on Diverse Immunological Pathways . Annals of the American Thoracic Society vol. 11 , ( Supplement 5 ) S314 - S321 .

( 2014 ) . 1<i>α</i>,25‐dihydroxyvitamin D3 in combination with transforming growth factor‐<i>β</i> increases the frequency of Foxp3⁺ regulatory T cells through preferential expansion and usage of interleukin‐2 . Immunology vol. 143 , ( 1 ) 52 - 60 .

( 2014 ) . The effects of calcitriol treatment in glucocorticoid-resistant asthma . Journal of Allergy and Clinical Immunology vol. 133 , ( 6 ) 1755 - 1757.e4 .

( 2014 ) . Immunoregulatory mechanisms of vitamin D relevant to respiratory health and asthma . Annals of the New York Academy of Sciences vol. 1317 , ( 1 ) 57 - 69 .

( 2014 ) . Corticosteroids enhance potentially pathogenic IL-17A+CD4+T cells . IMMUNOLOGY . vol. 143 , 83 - 84 .

( 2014 ) . The effects of calcitriol treatment in glucocorticoid-resistant asthma . JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY vol. 133 , ( 6 ) 1755 - 1757 .

( 2013 ) . Defective IL-10 expression and in vitro steroid-induced IL-17A in paediatric severe therapy-resistant asthma . Thorax vol. 69 , ( 6 ) 508 - 515 .

( 2013 ) . P193 A role for active Vitamin D in steroid resistant asthma patients who have enhanced production of IL-17A and reduced IL-10 . Thorax . vol. 68 , A163.2 - A163 .

( 2013 ) . Enhanced production of IL-17A in patients with severe asthma is inhibited by 1α,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion . Journal of Allergy and Clinical Immunology vol. 132 , ( 2 ) 297 - 304.e3 .

( 2012 ) . The role of 1α,25‐dihydroxyvitamin <scp>D</scp>3 and cytokines in the promotion of distinct <scp>F</scp>oxp3⁺and <scp>IL</scp>‐10⁺<scp>CD</scp>4⁺<scp>T</scp> cells . European Journal of Immunology vol. 42 , ( 10 ) 2697 - 2708 .

( 2012 ) . Serum 25-dihydroxyvitamin D levels correlate with CD4+Foxp3+ T-cell numbers in moderate/severe asthma . Journal of Allergy and Clinical Immunology vol. 130 , ( 2 ) 542 - 544 .

( 2011 ) . Differential production of IL-17 expression in peripheral blood cultures of steroid refractory versus steroid sensitive asthmatics . IMMUNOLOGY . vol. 135 , 188 - 188 .

( 2011 ) . Serum 25(OH)D levels can predict Foxp3+treg frequency and steroid responsiveness in severe asthmatics . IMMUNOLOGY . vol. 135 , 201 - 201 .

( 2011 ) . Steroid refractory asthma patients express lower levels of the immunomodulatory transcription factor FoxP3 and have lower levels of serum vitamin D . CLINICAL AND EXPERIMENTAL ALLERGY . vol. 41 , 1840 - 1840 .

( 2010 ) . The frequency of CD4(+) Foxp3(+) T cells is lower in the peripheral blood of steroid-refractory than steroid-sensitive asthmatics . IMMUNOLOGY . vol. 131 , 88 - 88 .

( 2010 ) . The Impact of Vitamin D on Regulatory T Cells . Current Allergy and Asthma Reports vol. 11 , ( 1 ) 29 - 36 .