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Research

Publications: DR Helen Rowe

( 2023 ) . Co-option of endogenous retroviruses through genetic escape from TRIM28 repression . Cell Reports vol. 42 , ( 6 ) Article 112625 , 112625 - 112625 .
( 2023 ) . Shrouded in genomic heterochromatin are ancient viral-like elements that could jump . Open Access Government vol. 37 , ( 1 ) 182 - 183 .
( 2022 ) . A satellite DNA array barcodes chromosome 7 and regulates totipotency via ZFP819 . Science Advances vol. 8 , ( 43 ) Article eabp8085 ,
( 2022 ) . Satellite DNA arrays barcode chromosomes to regulate genes . Open Access Government vol. 36 , ( 1 ) 138 - 139 .
( 2022 ) . Co-option of endogenous retroviruses through genetic escape from TRIM28 repression .
( 2022 ) . Implications of the first complete human genome assembly . Genome Research vol. 32 , ( 4 ) 595 - 598 .
( 2020 ) . Editorial Overview: Endogenous Retroviruses in Development and Disease . Viruses vol. 12 , ( 12 ) 1446 - 1446 .
( 2020 ) . The HUSH complex is a gatekeeper of type I interferon through epigenetic regulation of LINE-1s . Nature Communications vol. 11 , ( 1 ) Article 5387 ,
( 2020 ) . Host Gene Regulation by Transposable Elements: The New, the Old and the Ugly . Viruses vol. 12 , ( 10 ) 1089 - 1089 .
( 2019 ) . A nuclear licence to silence transposons . EMBO reports vol. 20 , ( 12 ) Article e49262 ,
( 2018 ) . <scp>KAP</scp>\n 1 regulates endogenous retroviruses in adult human cells and contributes to innate immune control . EMBO reports vol. 19 , ( 10 ) Article e45000 ,
( 2018 ) . The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes . Genome Research vol. 28 , ( 6 ) 836 - 845 .
( 2018 ) . Adeno-associated virus Rep proteins antagonize phosphatase PP1 to counteract KAP1 repression of the latent viral genome . Proceedings of the National Academy of Sciences vol. 115 , ( 15 )
( 2017 ) . Cancer cells, on your histone marks, get SETDB1, silence retrotransposons, and go! . Journal of Cell Biology vol. 216 , ( 11 ) 3429 - 3431 .
( 2017 ) . Epigenetic control of retrotransposons in adult tissues: implications for immune regulation . Current Opinion in Virology vol. 25 , 28 - 33 .
( 2016 ) . Transposable Elements and Their KRAB-ZFP Controllers Regulate Gene Expression in Adult Tissues . Developmental Cell vol. 36 , ( 6 ) 611 - 623 .
( 2016 ) . A Large-Scale Functional Screen to Identify Epigenetic Repressors of Retrotransposon Expression . Methods in Molecular Biology , Springer New York
( 2015 ) . Retrotransposons shape species-specific embryonic stem cell gene expression . Retrovirology vol. 12 , ( 1 ) Article 45 ,
( 2014 ) . Loss of transcriptional control over endogenous retroelements during reprogramming to pluripotency . Genome Research vol. 24 , ( 8 ) 1251 - 1259 .
( 2013 ) . Global and Stage Specific Patterns of Krüppel-Associated-Box Zinc Finger Protein Gene Expression in Murine Early Embryonic Cells . PLoS ONE vol. 8 , ( 2 ) e56721 - e56721 .
( 2013 ) . <i>De novo</i>DNA methylation of endogenous retroviruses is shaped by KRAB-ZFPs/KAP1 and ESET . Development vol. 140 , ( 3 ) 519 - 529 .
( 2012 ) . TRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells . Genome Research vol. 23 , ( 3 ) 452 - 461 .
( 2012 ) . Embryonic stem cell potency fluctuates with endogenous retrovirus activity . Nature vol. 487 , ( 7405 ) 57 - 63 .
( 2011 ) . Dynamic control of endogenous retroviruses during development . Virology vol. 411 , ( 2 ) 273 - 287 .
( 2010 ) . KAP1 controls endogenous retroviruses in embryonic stem cells . Nature vol. 463 , ( 7278 ) 237 - 240 .
( 2009 ) . Lentiviral Vectors Transduce Proliferating Dendritic Cell Precursors Leading to Persistent Antigen Presentation and Immunization . Molecular Therapy vol. 17 , ( 9 ) 1643 - 1650 .
( 2009 ) . Expression of vFLIP in a Lentiviral Vaccine Vector Activates NF-κB, Matures Dendritic Cells, and Increases CD8<sup>+</sup>T-Cell Responses . Journal of Virology vol. 83 , ( 4 ) 1555 - 1562 .
( 2006 ) . Immunization with a Lentiviral Vector Stimulates both CD4 and CD8 T Cell Responses to an Ovalbumin Transgene . Molecular Therapy vol. 13 , ( 2 ) 310 - 319 .