Publications: P Junchao Wang

( 2025 ) . Design of quinoline SARS-CoV-2 papain-like protease inhibitors as oral antiviral drug candidates . Nature Communications vol. 16 , ( 1 ) Article 1604 ,

( 2025 ) . Distal protein-protein interactions contribute to nirmatrelvir resistance . Nature Communications vol. 16 , ( 1 ) Article 1266 ,

( 2024 ) . Discovery of A-967079 as an Enterovirus D68 Antiviral by Targeting the Viral 2C Protein . ACS Infectious Diseases vol. 10 , ( 12 ) 4327 - 4336 .

( 2024 ) . Structure-Based Design of Covalent SARS-CoV-2 Papain-like Protease Inhibitors . Journal of Medicinal Chemistry vol. 67 , ( 22 ) 20399 - 20420 .

( 2023 ) . The EN-TEx resource of multi-tissue personal epigenomes & variant-impact models . Cell vol. 186 , ( 7 ) 1493 - 1511.e40 .

( 2022 ) . Discovery of mobocertinib, a new irreversible tyrosine kinase inhibitor indicated for the treatment of non-small-cell lung cancer harboring EGFR exon 20 insertion mutations . Medicinal Chemistry Research vol. 31 , ( 10 ) 1647 - 1662 .

( 2021 ) . The Genomic Landscape of Actinic Keratosis . Journal of Investigative Dermatology vol. 141 , ( 7 ) 1664 - 1674.e7 .

( 2021 ) . The Transcriptomic Landscape of Prostate Cancer Development and Progression: An Integrative Analysis . Cancers vol. 13 , ( 2 ) 345 - 345 .

( 2020 ) . Identification of Recurrent Mutations in the microRNA-Binding Sites of B-Cell Lymphoma-Associated Genes in Follicular Lymphoma . International Journal of Molecular Sciences vol. 21 , ( 22 ) 8795 - 8795 .

Gadaleta E, Fourgoux P, Pirró S, Thorn GJ, Nelan R, Ironside A, Rajeeve V, Cutillas PR et al. ( 2020 ) . Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer . npj Breast Cancer vol. 6 , ( 1 ) Article 38 ,

( 2020 ) . A frameshift variant in specificity protein 1 triggers superactivation of Sp1-mediated transcription in familial bone marrow failure . Proceedings of the National Academy of Sciences vol. 117 , ( 29 ) 17151 - 17155 .

( 2020 ) . Genetic heterogeneity highlighted by differential FDG-PET response in diffuse large B-cell lymphoma . Haematologica vol. 105 , ( 6 ) 318 - 321 .

Demircioglu F, Wang J, Candido J, Costa ASH, Casado P, de Luxan Delgado B, Reynolds LE, Gomez-Escudero J et al. ( 2020 ) . Cancer associated fibroblast FAK regulates malignant cell metabolism . Nature Communications vol. 11 , ( 1 ) Article 1290 ,

( 2020 ) . The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants . Nature Communications vol. 11 , ( 1 ) Article 1044 ,

Lu S, Zhang Z, Du P, Chard LS, Yan W, El Khouri M, Wang Z, Zhang Z et al. ( 2020 ) . A Virus-Infected, Reprogrammed Somatic Cell–Derived Tumor Cell (VIReST) Vaccination Regime Can Prevent Initiation and Progression of Pancreatic Cancer . Clinical Cancer Research vol. 26 , ( 2 ) 465 - 476 .

( 2019 ) . MLH1 deficiency leads to deregulated mitochondrial metabolism . Cell Death & Disease vol. 10 , ( 11 ) Article 795 ,

( 2019 ) . Epigenetic Regulation of iASPP-p63 Feedback Loop in Cutaneous Squamous Cell Carcinoma . Journal of Investigative Dermatology vol. 139 , ( 8 ) 1658 - 1671.e8 .

( 2019 ) . A Unique Panel of Patient-Derived Cutaneous Squamous Cell Carcinoma Cell Lines Provides a Preclinical Pathway for Therapeutic Testing . International Journal of Molecular Sciences vol. 20 , ( 14 ) 3428 - 3428 .

( 2019 ) . Correction: Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma . Leukemia vol. 33 , ( 6 ) 1540 - 1540 .

( 2019 ) . Applications and analysis of targeted genomic sequencing in cancer studies . Computational and Structural Biotechnology Journal vol. 17 , 1348 - 1359 .

( 2018 ) . The Identification and Interpretation of cis-Regulatory Noncoding Mutations in Cancer . High-Throughput vol. 8 , ( 1 ) 1 - 1 .

( 2018 ) . The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature . Nature Communications vol. 9 , ( 1 ) Article 3667 ,

( 2018 ) . Transmission of diffuse large B-cell lymphoma by an allogeneic stem-cell transplant . Haematologica vol. 104 , ( 4 ) e174 - e177 .

( 2018 ) . MicroRNA and transcriptome analysis in periocular Sebaceous Gland Carcinoma . Scientific Reports vol. 8 , ( 1 ) Article 7531 ,

Dayem Ullah AZ, Oscanoa J, Wang J, Nagano A, Lemoine NR, Chelala C ( 2018 ) . SNPnexus: assessing the functional relevance of genetic variation to facilitate the promise of precision medicine . Nucleic Acids Research vol. 46 , ( W1 ) W109 - W113 .

( 2018 ) . CSF1R+ Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype . Cell Reports vol. 23 , ( 5 ) 1448 - 1460 .

( 2018 ) . GATA2 monoallelic expression underlies reduced penetrance in inherited GATA2-mutated MDS/AML . Leukemia vol. 32 , ( 11 ) 2502 - 2507 .

( 2018 ) . Diagnostic and prognostic potential of serum miR-132/212 cluster in patients with hepatocellular carcinoma . Annals of Clinical Biochemistry: International Journal of Laboratory Medicine vol. 55 , ( 5 ) 576 - 582 .

( 2018 ) . Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma . Leukemia vol. 32 , ( 5 ) 1261 - 1265 .

( 2018 ) . Hsa_circ_0014717 is downregulated in colorectal cancer and inhibits tumor growth by promoting p16 expression . Biomedicine & Pharmacotherapy vol. 98 , 775 - 782 .

( 2018 ) . PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer . Cell Reports vol. 22 , ( 9 ) 2469 - 2481 .

( 2018 ) . IW-Scoring: an Integrative Weighted Scoring framework for annotating and prioritizing genetic variations in the noncoding genome . Nucleic Acids Research vol. 46 , ( 8 ) e47 - e47 .

Klymenko T, Bloehdorn J, Bahlo J, Robrecht S, Akylzhanova G, Cox K, Estenfelder S, Wang J et al. ( 2017 ) . Lamin B1 regulates somatic mutations and progression of B-cell malignancies . Leukemia vol. 32 , ( 2 ) 364 - 375 .

Sangaralingam A, Dayem Ullah AZ, Marzec J, Gadaleta E, Nagano A, Ross-Adams H, Wang J, Lemoine NR et al. ( 2017 ) . ‘Multi-omic’ data analysis using O-miner . Briefings in Bioinformatics vol. 20 , ( 1 ) 130 - 143 .

Wang J, Dumartin L, Mafficini A, Ulug P, Sangaralingam A, Alamiry NA, Radon TP, Salvia R et al. ( 2017 ) . Splice variants as novel targets in pancreatic ductal adenocarcinoma . Scientific Reports vol. 7 , ( 1 ) Article 2980 ,

( 2017 ) . Recurrent somatic JAK-STAT pathway variants within a RUNX1-mutated pedigree . European Journal of Human Genetics vol. 25 , ( 8 ) 1020 - 1024 .

( 2016 ) . Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma . Nature Communications vol. 7 , ( 1 ) Article 12493 ,

( 2016 ) . Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma . Cancer Research vol. 76 , ( 16 ) 4861 - 4871 .

( 2016 ) . Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1 . Cell Reports vol. 16 , ( 6 ) 1604 - 1613 .

( 2016 ) . Erratum: Corrigendum: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma . Nature Genetics vol. 48 , ( 6 ) 700 - 700 .

( 2016 ) . Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia . Leukemia vol. 30 , ( 11 ) 2179 - 2186 .

( 2016 ) . Longitudinal copy number, whole exome and targeted deep sequencing of 'good risk' IGHV-mutated CLL patients with progressive disease . Leukemia vol. 30 , ( 6 ) 1301 - 1310 .

( 2016 ) . Recurrent mTORC1-activating <i>RRAGC</i> mutations in follicular lymphoma . NATURE GENETICS vol. 48 , ( 2 ) 183 - 188 .

( 2015 ) . Genetics and Prognostication in Splenic Marginal Zone Lymphoma: Revelations from Deep Sequencing . Clinical Cancer Research vol. 21 , ( 18 ) 4174 - 4183 .

( 2015 ) . Disease evolution and outcomes in familial AML with germline CEBPA mutations . Blood vol. 126 , ( 10 ) 1214 - 1223 .

Yuan M, Zhang W, Wang J, Al Yaghchi C, Ahmed J, Chard L, Lemoine NR, Wang Y ( 2015 ) . Efficiently Editing the Vaccinia Virus Genome by Using the CRISPR-Cas9 System . Journal of Virology vol. 89 , ( 9 ) 5176 - 5179 .

Haider S, Wang J, Nagano A, Desai A, Arumugam P, Dumartin L, Fitzgibbon J, Hagemann T et al. ( 2014 ) . A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma . Genome Medicine vol. 6 , ( 12 ) Article 105 ,

( 2014 ) . Loss of imprinting at the 14q32 domain is associated with microRNA overexpression in acute promyelocytic leukemia . Blood vol. 123 , ( 13 ) 2066 - 2074 .

( 2013 ) . Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma . Nature Genetics vol. 46 , ( 2 ) 176 - 181 .

Ene–Obong A, Clear AJ, Watt J, Wang J, Fatah R, Riches JC, Marshall JF, Chin–Aleong J et al. ( 2013 ) . Activated Pancreatic Stellate Cells Sequester CD8+ T Cells to Reduce Their Infiltration of the Juxtatumoral Compartment of Pancreatic Ductal Adenocarcinoma . Gastroenterology vol. 145 , ( 5 ) 1121 - 1132 .

( 2013 ) . EZH2 mutations are frequent and represent an early event in follicular lymphoma . Blood vol. 122 , ( 18 ) 3165 - 3168 .

( 2013 ) . Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes . The Journal of Pathology vol. 230 , ( 1 ) 107 - 117 .

( 2012 ) . Three-point appraisal of genetic linkage maps . Theoretical and Applied Genetics vol. 125 , ( 7 ) 1393 - 1402 .

( 2012 ) . InterStoreDB: A Generic Integration Resource for Genetic and Genomic Data^F . Journal of Integrative Plant Biology vol. 54 , ( 5 ) 345 - 355 .

( 2011 ) . Regulatory Hotspots Are Associated with Plant Gene Expression under Varying Soil Phosphorus Supply in Brassica rapa . PLANT PHYSIOL vol. 156 , ( 3 ) 1230 - 1241 .

( 2011 ) . Integration of linkage maps for the Amphidiploid Brassica napus and comparative mapping with Arabidopsis and Brassica rapa . BMC GENOMICS vol. 12 , Article 101 ,

( 2007 ) . Effect of Divergence Time and Recombination Rate on Molecular Evolution of Drosophila INE-1 Transposable Elements and Other Candidates for Neutrally Evolving Sites . Journal of Molecular Evolution vol. 65 , ( 6 ) 627 - 639 .

( 2006 ) . MCALIGN2: Faster, accurate global pairwise alignment of non-coding DNA sequences based on explicit models of indel evolution . BMC BIOINFORMATICS vol. 7 , Article 292 ,