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  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: DR Benjamin Werner

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Lumeau A, Guscott MA, Pere NM, Nichols I, Werner B, Dusetti N, McClelland SE ( 2025 ) . Abstract B129: Tracking genome evolution and chemoresistance in pancreatic cancer . Cancer Research vol. 85 , ( 18_Supplement_3 ) b129 - b129 .
Noorani I, Haughey M, Luebeck J, Rowan A, Grönroos E, Terenzi F, Wong IT-L, Pradella D et al. ( 2025 ) . Extrachromosomal DNA–Driven Oncogene Spatial Heterogeneity and Evolution in Glioblastoma . Cancer Discovery vol. 15 , ( 10 ) 2078 - 2095 .
Montuori G, Tu F, Qin D, Schmargon R, Rodriguez-Fos E, Helmsauer K, Hui H, Mandal S et al. ( 2025 ) . Extrachromosomal DNA-Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers . Cancer Discovery vol. 15 , ( 10 ) 2054 - 2077 .
Haughey M, Noorani I, Swanton C, Mischel PS, Werner B ( 2025 ) . Extrachromosomal DNA: shaping the evolutionary dynamics of cancer . Trends in Cancer vol. 11 , ( 9 ) 901 - 916 .
Stein A, Werner B ( 2025 ) . On the patterns of genetic intra-tumor heterogeneity before and after treatment . Genetics vol. 230 , ( 4 )
Scanu E, Werner B, Huang W ( 2024 ) . Population dynamics of multiple ecDNA types .
Hung KL, Jones MG, Wong IT-L, Curtis EJ, Lange JT, He BJ, Luebeck J, Schmargon R et al. ( 2024 ) . Coordinated inheritance of extrachromosomal DNAs in cancer cells . Nature vol. 635 , ( 8037 ) 201 - 209 .
Noorani I, Haughey M, Luebeck J, Rowan A, Grönroos E, Terenzi F, Wong IT-L, Kittel J et al. ( 2024 ) . Extrachromosomal DNA driven oncogene spatial heterogeneity and evolution in glioblastoma .
Moeller M, Werner B, Huang W ( 2024 ) . Accumulating waves of random mutations before fixation . Physical Review E vol. 110 , ( 4 )
Noorani I, Haughey M, Luebeck J, Rowan A, Gronroos EC, Bafna V, Huang W, Mischel P et al. ( 2024 ) . 111MO Extrachromosomal DNA drives oncogene spatial heterogeneity in IDH-wildtype glioblastomas . ESMO Open vol. 9 ,
Kayhanian H, Cross W, van der Horst SEM, Barmpoutis P, Lakatos E, Caravagna G, Zapata L, Van Hoeck A et al. ( 2024 ) . Homopolymer switches mediate adaptive mutability in mismatch repair-deficient colorectal cancer . Nature Genetics vol. 56 , ( 7 ) 1420 - 1433 .
Yu L, Renton J, Burian A, Khachaturyan M, Bayer T, Kotta J, Stachowicz JJ, DuBois K et al. ( 2024 ) . A somatic genetic clock for clonal species . Nature Ecology & Evolution vol. 8 , ( 7 ) 1327 - 1336 .
Moeller ME, Mon Père NV, Werner B, Huang W ( 2024 ) . Measures of genetic diversification in somatic tissues at bulk and single-cell resolution . eLife vol. 12 ,
Li H, Yang Z, Tu F, Deng L, Han Y, Fu X, Wang L, Gu D et al. ( 2023 ) . Mutation divergence over space in tumour expansion . Journal of The Royal Society Interface vol. 20 , ( 208 )
Cereser B, Yiu A, Tabassum N, Del Bel Belluz L, Zagorac S, Ancheta KRZ, Zhong R, Miere C et al. ( 2023 ) . The mutational landscape of the adult healthy parous and nulliparous human breast . Nature Communications vol. 14 , ( 1 )
Zapata L, Caravagna G, Williams MJ, Lakatos E, AbdulJabbar K, Werner B, Chowell D, James C et al. ( 2023 ) . Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors . Nature Genetics vol. 55 , ( 3 ) 451 - 460 .
Househam J, Heide T, Cresswell GD, Spiteri I, Kimberley C, Zapata L, Lynn C, James C et al. ( 2022 ) . Phenotypic plasticity and genetic control in colorectal cancer evolution . Nature vol. 611 , ( 7937 ) 744 - 753 .
Lange JT, Rose JC, Chen CY, Pichugin Y, Xie L, Tang J, Hung KL, Yost KE et al. ( 2022 ) . The evolutionary dynamics of extrachromosomal DNA in human cancers . Nature Genetics vol. 54 , ( 10 ) 1527 - 1533 .
Tari H, Kessler K, Trahearn N, Werner B, Vinci M, Jones C, Sottoriva A ( 2022 ) . Quantification of spatial subclonal interactions enhancing the invasive phenotype of pediatric glioma . Cell Reports vol. 40 , ( 9 )
Werner B ( 2021 ) . Shining light on dark selection in healthy human tissues . Nature Genetics vol. 53 , ( 11 ) 1525 - 1526 .
Reusch TBH, Baums IB, Werner B ( 2021 ) . Evolution via somatic genetic variation in modular species . Trends in Ecology & Evolution
Graham T, Eszter L, Marc W, Ryan S, William C, Jacob H, Luis Z, Benjamin W et al. ( 2020 ) . Evolutionary dynamics of neoantigens in growing tumours . Nature Genetics
Graham T, Caravagna G, Heide T, Williams M, Zapata L, Daniel N, Ketevan C, Cross W et al. ( 2020 ) . Subclonal reconstruction of tumors using machine learning and population genetics . Nature Genetics vol. 52 , 898 - 907 .
Acar A, Nichol D, Fernandez-Mateos J, Cresswell GD, Barozzi I, Hong SP, Trahearn N, Spiteri I et al. ( 2020 ) . Exploiting evolutionary steering to induce collateral drug sensitivity in cancer . Nature Communications vol. 11 , ( 1 ) Article 1923 ,
Williams MJ, Zapata L, Werner B, Barnes CP, Sottoriva A, Graham TA ( 2020 ) . Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios . eLife vol. 9 ,
Werner B, Case J, Williams MJ, Chkhaidze K, Temko D, Fernández-Mateos J, Cresswell GD, Nichol D et al. ( 2020 ) . Measuring single cell divisions in human tissues from multi-region sequencing data . Nature Communications vol. 11 , ( 1 )
Pichugin Y, Huang W, Werner B ( 2019 ) . Stochastic dynamics of extra-chromosomal DNA .
Retel C, Kowallik V, Huang W, Werner B, Becks L, Feulner P, Huang W ( 2019 ) . The feedback between selection and demography shapes genomic diversity during coevolution . Science Advances
Chkhaidze K, Heide T, Werner B, Williams MJ, Huang W, Caravagna G, Graham TA, Sottoriva A ( 2019 ) . Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data . PLOS Computational Biology vol. 15 , ( 7 )
Chkhaidze K, Heide T, Werner B, Williams MJ, Huang W, Caravagna G, Baker A-M, Graham TA et al. ( 2019 ) . Abstract 4232: Spatially constrained tumor growth affects the patterns of clonal selection and neutral drift in cancer genomic data . Cancer Research . vol. 79 , 4232 - 4232 .
Williams MJ, Zapata L, Werner B, Barnes C, Sottoriva A, Graham TA ( 2019 ) . Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios .
Opasic L, Zhou D, Werner B, Dingli D, Traulsen A ( 2019 ) . How many samples are needed to infer truly clonal mutations from heterogenous tumours? . BMC Cancer vol. 19 , ( 1 )
Caravagna G, Heide T, Williams M, Zapata L, Nichol D, Chkhaidze K, Cross W, Cresswell GD et al. ( 2019 ) . Model-based tumor subclonal reconstruction .
Werner B, Case J, Williams MJ, Chkhaidze K, Temko D, Fernandez-Mateos J, Cresswell GD, Nichol D et al. ( 2019 ) . Measuring single cell divisions in human cancers from multi-region sequencing data .
Chkhaidze K, Heide T, Werner B, Williams MJ, Huang W, Caravagna G, Graham TA, Sottoriva A ( 2019 ) . Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data .
Lakatos E, Williams MJ, Schenck RO, Cross WCH, Househam J, Werner B, Gatenbee C, Robertson-Tessi M et al. ( 2019 ) . Evolutionary dynamics of neoantigens in growing tumours .
Spiteri I, Caravagna G, Cresswell GD, Vatsiou A, Nichol D, Acar A, Ermini L, Chkhaidze K et al. ( 2018 ) . Evolutionary dynamics of residual disease in human glioblastoma . Annals of Oncology vol. 30 , ( 3 ) 456 - 463 .
Werner B, Williams MJ, Barnes CP, Graham TA, Sottoriva A ( 2018 ) . Reply to ‘Currently available bulk sequencing data do not necessarily support a model of neutral tumor evolution’ . Nature Genetics vol. 50 , ( 12 ) 1624 - 1626 .
Heide T, Zapata L, Williams MJ, Werner B, Caravagna G, Barnes CP, Graham TA, Sottoriva A ( 2018 ) . Reply to ‘Neutral tumor evolution?’ . Nature Genetics vol. 50 , ( 12 ) 1633 - 1637 .
Khan KH, Cunningham D, Werner B, Vlachogiannis G, Spiteri I, Heide T, Mateos JF, Vatsiou A et al. ( 2018 ) . Longitudinal Liquid Biopsy and Mathematical Modeling of Clonal Evolution Forecast Time to Treatment Failure in the PROSPECT-C Phase II Colorectal Cancer Clinical Trial . Cancer Discovery vol. 8 , ( 10 ) 1270 - 1285 .
Williams MJ, Werner B, Heide T, Barnes CP, Graham TA, Sottoriva A ( 2018 ) . Reply to ‘Revisiting signatures of neutral tumor evolution in the light of complexity of cancer genomic data’ . Nature Genetics vol. 50 , ( 12 ) 1628 - 1630 .
Böttcher MA, Dingli D, Werner B, Traulsen A ( 2018 ) . Replicative cellular age distributions in compartmentalized tissues . Journal of The Royal Society Interface vol. 15 , ( 145 )
Williams MJ, Werner B, Heide T, Curtis C, Barnes CP, Sottoriva A, Graham TA ( 2018 ) . Author Correction: Quantification of subclonal selection in cancer from bulk sequencing data . Nature Genetics vol. 50 , ( 9 ) 1342 - 1342 .
Werner B, Sottoriva A ( 2018 ) . Variation of mutational burden in healthy human tissues suggests non-random strand segregation and allows measuring somatic mutation rates . PLOS Computational Biology vol. 14 , ( 6 )
Werner B, Sottoriva A ( 2018 ) . Variation of mutational burden in healthy human tissues suggests non-random strand segregation and allows measuring somatic mutation rates .
Böttcher MA, Werner B, Dingli D, Traulsen A ( 2018 ) . Replicative cellular age distributions in compartmentalised tissues .
Heide T, Zapata L, Williams MJ, Werner B, Barnes CP, Graham TA, Sottoriva A ( 2018 ) . Reply: Neutral tumor evolution? .
Williams MJ, Werner B, Barnes CP, Graham TA, Sottoriva A ( 2018 ) . Reply: Is the evolution of tumors Darwinian or non-Darwinian? . National Science Review vol. 5 , ( 1 ) 17 - 19 .
Huang W, Traulsen A, Werner B, Hiltunen T, Becks L ( 2017 ) . Dynamical trade-offs arise from antagonistic coevolution and decrease intraspecific diversity . Nat Commun vol. 8 , ( 1 ) 2059 - 2059 .
Williams MJ, Werner B, Barnes CP, Graham TA, Sottoriva A ( 2017 ) . Reply: Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures . Nature Genetics vol. 49 , ( 9 ) 1289 - 1291 .
Werner B, Traulsen A, Sottoriva A, Dingli D ( 2017 ) . Detecting truly clonal alterations from multi-region profiling of tumours . Scientific Reports vol. 7 , ( 1 )
Lote H, Spiteri I, Ermini L, Vatsiou A, Roy A, McDonald A, Maka N, Balsitis M et al. ( 2017 ) . Carbon dating cancer: defining the chronology of metastatic progression in colorectal cancer . Annals of Oncology vol. 28 , ( 6 ) 1243 - 1249 .
Williams MJ, Werner B, Curtis C, Barnes CP, Sottoriva A, Graham TA ( 2016 ) . Quantification of subclonal selection in cancer from bulk sequencing data .
Werner B, Traulsen A, Dingli D ( 2016 ) . Response to the Editor: On the Growth of Hematopoietic Stem Cells and Childhood Leukemias . Stem Cells vol. 34 , ( 10 ) 2610 - 2610 .
Hindersin L, Werner B, Dingli D, Traulsen A ( 2016 ) . Should tissue structure suppress or amplify selection to minimize cancer risk? . Biology Direct vol. 11 , ( 1 )
Williams MJ, Werner B, Graham TA, Sottoriva A ( 2016 ) . Functional versus non-functional intratumor heterogeneity in cancer . Molecular & Cellular Oncology vol. 3 , ( 4 ) e1162897 - e1162897 .
Werner B, Scott JG, Sottoriva A, Anderson ARA, Traulsen A, Altrock PM ( 2016 ) . The Cancer Stem Cell Fraction in Hierarchically Organized Tumors Can Be Estimated Using Mathematical Modeling and Patient-Specific Treatment Trajectories . Cancer Research vol. 76 , ( 7 ) 1705 - 1713 .
Williams MJ, Werner B, Barnes CP, Graham TA, Sottoriva A ( 2016 ) . Identification of neutral tumor evolution across cancer types . Nature Genetics vol. 48 , ( 3 ) 238 - 244 .
Sottoriva A, Graham TA, Werner B, Williams M, Barnes C ( 2016 ) . Neutral Evolution in Colorectal Cancer: How Can We Distinguish Functional from Non-functional Variation? . JOURNAL OF PATHOLOGY . vol. 240 , 7 - 7 .
Werner B, Traulsen A, Dingli D ( 2015 ) . Ontogenic growth as the root of fundamental differences between childhood and adult cancer . Stem Cells vol. 34 , ( 3 ) 543 - 550 .
Bouillon A-S, Ferreira MS, Werner B, Hummel S, Panse JP, Reinecke P, Schemenau J, Haas R et al. ( 2015 ) . Comprehensive Analysis of Telomere Biology in Patients with Aplastic Anemia and Hypoplastic Myelodysplastic Syndrome: Further Evidence for a Common Mechanism . Blood vol. 126 , ( 23 )
Werner B, Beier F, Hummel S, Balabanov S, Lassay L, Orlikowsky T, Dingli D, Brümmendorf TH et al. ( 2015 ) . Reconstructing the in vivo dynamics of hematopoietic stem cells from telomere length distributions . eLife vol. 4 ,
Werner B, Gallagher RE, Paietta EM, Litzow MR, Tallman MS, Wiernik PH, Slack JL, Willman CL et al. ( 2014 ) . Dynamics of Leukemia Stem-like Cell Extinction in Acute Promyelocytic Leukemia . Cancer Research vol. 74 , ( 19 ) 5386 - 5396 .
Schulz R, Werner B, Behn U ( 2014 ) . Self-Tolerance in a Minimal Model of the Idiotypic Network . Frontiers in Immunology vol. 5 ,
Werner B, Dingli D, Traulsen A ( 2013 ) . A deterministic model for the occurrence and dynamics of multiple mutations in hierarchically organized tissues . Journal of The Royal Society Interface vol. 10 , ( 85 )
Werner B, Dingli D, Traulsen A ( 2013 ) . A deterministic model for the occurrence and dynamics of multiple mutations in hierarchically organized tissues .
Glauche I, Bystrykh L, Eaves C, Roeder I, participants O ( 2013 ) . Stem cell clonality — Theoretical concepts, experimental techniques, and clinical challenges . Blood Cells Molecules and Diseases vol. 50 , ( 4 ) 232 - 240 .
Huang W, Werner B, Traulsen A ( 2012 ) . The impact of random frequency-dependent mutations on the average population fitness . BMC Ecology and Evolution vol. 12 , ( 1 )
Werner B, Lutz D, Brümmendorf TH, Traulsen A, Balabanov S ( 2011 ) . Dynamics of Resistance Development to Imatinib under Increasing Selection Pressure: A Combination of Mathematical Models and In Vitro Data . PLOS ONE vol. 6 , ( 12 )
Werner B, Dingli D, Lenaerts T, Pacheco JM, Traulsen A ( 2011 ) . Dynamics of Mutant Cells in Hierarchical Organized Tissues . PLOS Computational Biology vol. 7 , ( 12 )
Moeller M, Werner B, Huang W . Accumulating waves of random mutations before fixation .
Heide T, Househam J, Cresswell GD, Spiteri I, Lynn C, Kimberley C, Mossner M, Zapata L et al. . Assessment of the evolutionary consequence of putative driver mutations in colorectal cancer with spatial multiomic data .
Ahmed I, Dingli D, Huang W, Werner B . Clonal fitness decline in somatic differentiation hierarchies .
Hung KL, Jones MG, Wong IT-L, Lange JT, Luebeck J, Scanu E, He BJ, Brückner L et al. . Coordinated inheritance of extrachromosomal DNA species in human cancer cells .
Werner B, Scott JG, Sottoriva A, Anderson ARA, Traulsen A, Altrock PM . Estimating stem cell fractions in hierarchically organized tumors .
Opasic L, Zhou D, Werner B, Dingli D, Traulsen A . How many samples are needed to infer truly clonal mutations from heterogenous tumours? .
Moeller ME, Père NVM, Werner B, Huang W . Measures of genetic diversification in somatic tissues at bulk and single cell resolution .
Conn T, Renton J, Chamberland VF, Dellaert Z, Reusch TBH, Werner B, Baums IB . Mosaic accumulation of somatic genetic variation and estimates of age in the long-lived reef-building coral Acropora palmata .
Kayhanian H, Barmpoutis P, Lakatos E, Cross W, Caravagna G, Zapata L, Litchfield K, Steele C et al. . Mutation Rate Evolution Drives Immune Escape In Mismatch Repair-Deficient Cancer .
Li H, Tu F, Deng L, Yang Z, Han Y, Fu X, Wang L, Gu D et al. . Mutation divergence over space in tumour expansion .
Cereser B, Tabassum N, Del Bel Belluz L, Yiu A, Zagorac S, Miere C, Werner B, Moderau N et al. . Mutational landscapes of normal breast during age and pregnancy determine cancer risk .
Stein A, Werner B . On the patterns of genetic intra-tumour heterogeneity before and after treatment .
Brückner L, Xu R, Tang J, Herrmann A, Wong IT-L, Zhang S, Tu F, Pilon M et al. . Oncogene Silencing via ecDNA Micronucleation .
Yu L, Renton J, Burian A, Khachaturyan M, Kotta J, Stachowicz JJ, DuBois K, Baums IB et al. . Precise age estimation in clonal species using a somatic genetic clock .
Lange JT, Chen CY, Pichugin Y, Xie L, Tang J, Hung L, Yost KE, Shi Q et al. . Principles of ecDNA random inheritance drive rapid genome change and therapy resistance in human cancers .
Tari H, Kessler K, Trahearn N, Werner B, Vinci M, Jones C, Sottoriva A . Quantification of spatial subclonal interactions enhancing the invasive phenotype of paediatric glioma .
GRAHAM TA, WILLIAMS MJ, Benjamin W, Timon H, Christina C, Barnes CP, Andrea S . Quantification of subclonal selection in cancer from bulk sequencing data . Nature Genetics
Hindersin L, Werner B, Dingli D, Traulsen A . Should tissue structure suppress or amplify selection to minimize cancer risk? .
Père NM, Terenzi F, Werner B . The dynamic fitness landscape of ageing haematopoiesis through clonal competition .
Scanu E, Werner B, Huang W . The maintenance and de-mixing of extrachromosomal DNA variants in single cells .
Zapata L, Caravagna G, Williams MJ, Lakatos E, AbdulJabbar K, Werner B, Graham TA, Sottoriva A . dN/dS dynamics quantify tumour immunogenicity and predict response to immunotherapy .
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