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  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: DR Benjamin Werner

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( 2025 ) . Extrachromosomal DNA-Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in <i>MYCN</i>-Amplified Cancers . Cancer DiscoveryOF1 - OF24 .
( 2025 ) . Extrachromosomal DNA: shaping the evolutionary dynamics of cancer . Trends in Cancer
( 2025 ) . On the patterns of genetic intra-tumor heterogeneity before and after treatment . GENETICS Article iyaf101 ,
( 2025 ) . Oncogene Silencing via ecDNA Micronucleation .
( 2025 ) . Mosaic accumulation of somatic genetic variation and estimates of age in the long-lived reef-building coral <i>Acropora palmata</i> .
( 2024 ) . Population dynamics of multiple ecDNA types .
( 2024 ) . Coordinated inheritance of extrachromosomal DNAs in cancer cells . Nature vol. 635 , ( 8037 ) 201 - 209 .
( 2024 ) . Extrachromosomal DNA driven oncogene spatial heterogeneity and evolution in glioblastoma .
( 2024 ) . The maintenance and de-mixing of extrachromosomal DNA variants in single cells .
( 2024 ) . Accumulating waves of random mutations before fixation . Physical Review E vol. 110 , ( 4 ) Article 044404 ,
( 2024 ) . On the patterns of genetic intra-tumour heterogeneity before and after treatment .
( 2024 ) . 111MO Extrachromosomal DNA drives oncogene spatial heterogeneity in IDH-wildtype glioblastomas . ESMO Open vol. 9 , Article 103850 , 103850 - 103850 .
( 2024 ) . Homopolymer switches mediate adaptive mutability in mismatch repair-deficient colorectal cancer . Nature Genetics vol. 56 , ( 7 ) 1420 - 1433 .
( 2024 ) . A somatic genetic clock for clonal species . Nature Ecology &amp; Evolution vol. 8 , ( 7 ) 1327 - 1336 .
( 2024 ) . The dynamic fitness landscape of ageing haematopoiesis through clonal competition .
( 2024 ) . Measures of genetic diversification in somatic tissues at bulk and single-cell resolution . eLife vol. 12 , Article RP89780 ,
( 2023 ) . Mutation divergence over space in tumour expansion . Journal of The Royal Society Interface vol. 20 , ( 208 ) Article 20230542 ,
( 2023 ) . Precise age estimation in clonal species using a somatic genetic clock .
( 2023 ) . Clonal fitness decline in somatic differentiation hierarchies .
( 2023 ) . The mutational landscape of the adult healthy parous and nulliparous human breast . Nature Communications vol. 14 , ( 1 ) Article 5136 ,
( 2023 ) . Coordinated inheritance of extrachromosomal DNA species in human cancer cells .
( 2023 ) . Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors . Nature Genetics vol. 55 , ( 3 ) 451 - 460 .
( 2022 ) . Mutation divergence over space in tumour expansion .
( 2022 ) . Measures of genetic diversification in somatic tissues at bulk and single cell resolution .
( 2022 ) . Phenotypic plasticity and genetic control in colorectal cancer evolution . Nature vol. 611 , ( 7937 ) 744 - 753 .
( 2022 ) . The evolutionary dynamics of extrachromosomal DNA in human cancers . Nature Genetics vol. 54 , ( 10 ) 1527 - 1533 .
( 2022 ) . Quantification of spatial subclonal interactions enhancing the invasive phenotype of pediatric glioma . Cell Reports vol. 40 , ( 9 ) Article 111283 , 111283 - 111283 .
( 2022 ) . Accumulating waves of random mutations before fixation .
( 2022 ) . Mutation Rate Evolution Drives Immune Escape In Mismatch Repair-Deficient Cancer .
( 2021 ) . Evolution via somatic genetic variation in modular species . Trends in Ecology &amp; Evolution vol. 36 , ( 12 ) 1083 - 1092 .
( 2021 ) . Shining light on dark selection in healthy human tissues . Nature Genetics vol. 53 , ( 11 ) 1525 - 1526 .
( 2021 ) . Quantification of spatial subclonal interactions enhancing the invasive phenotype of paediatric glioma .
( 2021 ) . Assessment of the evolutionary consequence of putative driver mutations in colorectal cancer with spatial multiomic data .
( 2021 ) . Principles of ecDNA random inheritance drive rapid genome change and therapy resistance in human cancers .
( 2020 ) . Evolutionary dynamics of neoantigens in growing tumors . Nature Genetics vol. 52 , ( 10 ) 1057 - 1066 .
( 2020 ) . Mutational landscapes of normal breast during age and pregnancy determine cancer risk .
( 2020 ) . Subclonal reconstruction of tumors by using machine learning and population genetics . Nature Genetics vol. 52 , ( 9 ) 898 - 907 .
( 2020 ) . <i>dN/dS</i>dynamics quantify tumour immunogenicity and predict response to immunotherapy .
( 2020 ) . Exploiting evolutionary steering to induce collateral drug sensitivity in cancer . Nature Communications vol. 11 , ( 1 ) Article 1923 ,
( 2020 ) . Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios . eLife vol. 9 , Article e48714 ,
( 2020 ) . Measuring single cell divisions in human tissues from multi-region sequencing data . Nature Communications vol. 11 , ( 1 ) Article 1035 ,
( 2019 ) . Stochastic dynamics of extra-chromosomal DNA .
( 2019 ) . The feedback between selection and demography shapes genomic diversity during coevolution . Science Advances vol. 5 , ( 10 ) Article eaax0530 ,
( 2019 ) . Abstract 4232: Spatially constrained tumor growth affects the patterns of clonal selection and neutral drift in cancer genomic data . Cancer Research . vol. 79 , 4232 - 4232 .
( 2019 ) . Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios .
( 2019 ) . How many samples are needed to infer truly clonal mutations from heterogenous tumours? . BMC Cancer vol. 19 , ( 1 ) Article 403 ,
( 2019 ) . How many samples are needed to infer truly clonal mutations from heterogenous tumours? .
( 2019 ) . Model-based tumor subclonal reconstruction .
( 2019 ) . Evolutionary dynamics of residual disease in human glioblastoma . Annals of Oncology vol. 30 , ( 3 ) 456 - 463 .
( 2019 ) . Measuring single cell divisions in human cancers from multi-region sequencing data .
( 2019 ) . Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data .
( 2019 ) . Evolutionary dynamics of neoantigens in growing tumours .
( 2019 ) . Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data . PLoS Comput. Biol. vol. 15 , Article 7 ,
( 2018 ) . Reply to ‘Currently available bulk sequencing data do not necessarily support a model of neutral tumor evolution’ . Nature Genetics vol. 50 , ( 12 ) 1624 - 1626 .
( 2018 ) . Reply to ‘Neutral tumor evolution?’ . Nature Genetics vol. 50 , ( 12 ) 1633 - 1637 .
( 2018 ) . Longitudinal Liquid Biopsy and Mathematical Modeling of Clonal Evolution Forecast Time to Treatment Failure in the PROSPECT-C Phase II Colorectal Cancer Clinical Trial . Cancer Discovery vol. 8 , ( 10 ) 1270 - 1285 .
( 2018 ) . Reply to ‘Revisiting signatures of neutral tumor evolution in the light of complexity of cancer genomic data’ . Nature Genetics vol. 50 , ( 12 ) 1628 - 1630 .
( 2018 ) . Replicative cellular age distributions in compartmentalized tissues . Journal of The Royal Society Interface vol. 15 , ( 145 ) 20180272 - 20180272 .
( 2018 ) . Author Correction: Quantification of subclonal selection in cancer from bulk sequencing data . Nature Genetics vol. 50 , ( 9 ) 1342 - 1342 .
( 2018 ) . Variation of mutational burden in healthy human tissues suggests non-random strand segregation and allows measuring somatic mutation rates . PLOS Computational Biology vol. 14 , ( 6 ) e1006233 - e1006233 .
( 2018 ) . Variation of mutational burden in healthy human tissues suggests non-random strand segregation and allows measuring somatic mutation rates .
( 2018 ) . Quantification of subclonal selection in cancer from bulk sequencing data . Nature Genetics vol. 50 , ( 6 ) 895 - 903 .
( 2018 ) . Replicative cellular age distributions in compartmentalised tissues .
( 2018 ) . Reply: Neutral tumor evolution? .
( 2018 ) . Reply: Is the evolution of tumors Darwinian or non-Darwinian? . National Science Review vol. 5 , ( 1 ) 17 - 19 .
( 2017 ) . Dynamical trade-offs arise from antagonistic coevolution and decrease intraspecific diversity . Nature Communications vol. 8 , ( 1 ) Article 2059 ,
( 2017 ) . Reply: Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures . Nature Genetics vol. 49 , ( 9 ) 1289 - 1291 .
( 2017 ) . Carbon dating cancer: defining the chronology of metastatic progression in colorectal cancer . Annals of Oncology vol. 28 , ( 6 ) 1243 - 1249 .
( 2017 ) . Detecting truly clonal alterations from multi-region profiling of tumours . Scientific Reports vol. 7 , ( 1 ) Article 44991 ,
( 2016 ) . Quantification of subclonal selection in cancer from bulk sequencing data .
( 2016 ) . Response to the Editor: On the Growth of Hematopoietic Stem Cells and Childhood Leukemias . Stem Cells vol. 34 , ( 10 ) 2610 - 2610 .
( 2016 ) . Should tissue structure suppress or amplify selection to minimize cancer risk? . Biology Direct vol. 11 , ( 1 ) Article 41 ,
( 2016 ) . Should tissue structure suppress or amplify selection to minimize cancer risk? .
( 2016 ) . Functional versus non-functional intratumor heterogeneity in cancer . Molecular &amp; Cellular Oncology vol. 3 , ( 4 ) e1162897 - e1162897 .
( 2016 ) . The Cancer Stem Cell Fraction in Hierarchically Organized Tumors Can Be Estimated Using Mathematical Modeling and Patient-Specific Treatment Trajectories . Cancer Research vol. 76 , ( 7 ) 1705 - 1713 .
( 2016 ) . Identification of neutral tumor evolution across cancer types . Nature Genetics vol. 48 , ( 3 ) 238 - 244 .
( 2016 ) . Neutral Evolution in Colorectal Cancer: How Can We Distinguish Functional from Non-functional Variation? . JOURNAL OF PATHOLOGY . vol. 240 , 7 - 7 .
( 2015 ) . Ontogenic growth as the root of fundamental differences between childhood and adult cancer . Stem Cells vol. 34 , ( 3 ) 543 - 550 .
( 2015 ) . Comprehensive Analysis of Telomere Biology in Patients with Aplastic Anemia and Hypoplastic Myelodysplastic Syndrome: Further Evidence for a Common Mechanism . Blood vol. 126 , ( 23 ) 2858 - 2858 .
( 2015 ) . Reconstructing the in vivo dynamics of hematopoietic stem cells from telomere length distributions . eLife vol. 4 , Article e08687 ,
( 2015 ) . Estimating stem cell fractions in hierarchically organized tumors .
( 2014 ) . Dynamics of Leukemia Stem-like Cell Extinction in Acute Promyelocytic Leukemia . Cancer Research vol. 74 , ( 19 ) 5386 - 5396 .
( 2014 ) . Self-Tolerance in a Minimal Model of the Idiotypic Network . Frontiers in Immunology vol. 5 ,
( 2013 ) . A deterministic model for the occurrence and dynamics of multiple mutations in hierarchically organized tissues . Journal of The Royal Society Interface vol. 10 , ( 85 ) 20130349 - 20130349 .
( 2013 ) . A deterministic model for the occurrence and dynamics of multiple mutations in hierarchically organized tissues .
( 2013 ) . Stem cell clonality — Theoretical concepts, experimental techniques, and clinical challenges . Blood Cells, Molecules, and Diseases vol. 50 , ( 4 ) 232 - 240 .
( 2012 ) . The impact of random frequency-dependent mutations on the average population fitness . BMC Evolutionary Biology vol. 12 , ( 1 ) Article 160 ,
( 2011 ) . Dynamics of Resistance Development to Imatinib under Increasing Selection Pressure: A Combination of Mathematical Models and In Vitro Data . PLoS ONE vol. 6 , ( 12 ) e28955 - e28955 .
( 2011 ) . Dynamics of Mutant Cells in Hierarchical Organized Tissues . PLoS Computational Biology vol. 7 , ( 12 ) e1002290 - e1002290 .
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