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Research
  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: DR Wenhao Li

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( 2025 ) . Combination therapies for metabolic dysfunction-associated steatohepatitis: challenges and opportunities . Gut
Huang H-T, Hewitt M, Li W, Alazawi W ( 2025 ) . Real-world evidence in metabolic dysfunction-associated steatotic liver disease (MASLD): insights, challenges, and future directions . The Lancet Regional Health - Europe vol. 62 ,
Pekarska K, Brennan PN, Wajcman DI, Towey J, Cox L, Weatherby K, McPherson S, Stine J et al. ( 2025 ) . Nutrition in MASLD: a patient focused, evidence-based clinician’s guide . Frontline Gastroenterology
( 2025 ) . Current and emerging therapeutic landscape for metabolic dysfunction-associated steatohepatitis . The Lancet Gastroenterology & Hepatology vol. 11 , ( 2 ) 150 - 162 .
Lim RY, Tan FXN, Ho GJK, Tham EKJ, Kow A, Lv G, Fan Z-Q, Syn N et al. ( 2025 ) . Incidence of Hepatocellular Carcinoma in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Reconstructed Individual Patient Data Meta-Analysis . Clinical Gastroenterology and Hepatology
( 2025 ) . Longitudinal Changes in Fibrosis Markers: Monitoring Stiffness/Fibrosis Progression and Prognostic Outcomes in MASLD . Clinical Gastroenterology and Hepatology vol. 24 , ( 2 ) 394 - 406 .
Spiers J, Li W, Aravinthan AD, Bannaga A, Caddick K, Culver EL, Faulkes RE, Gordon V et al. ( 2025 ) . Current Surveillance Strategy Is Less Effective for Detecting Early-Stage Hepatocellular Carcinoma in Patients with Non-Viral and Non-Cirrhotic Liver Disease . Liver Cancer vol. 14 , ( 5 ) 587 - 600 .
Perez Ternero C, Li W, Aubdool AA, Goldin RD, Loy J, Devalia K, Alazawi W, Hobbs AJ ( 2024 ) . Endogenous C-type natriuretic peptide offsets the pathogenesis of steatohepatitis, hepatic fibrosis and portal hypertension . PNAS Nexuspgae579 - pgae579 .
Li W, Boot J, Mein C, Loy J, Devalia K, Kendall T, Ramos MJ, Fallowfield J et al. ( 2024 ) . P32 Toll-like receptor (TLR)5 mediates deleterious effects of lipid injury and fibrogenic responses in metabolic dysfunction-associated steatohepatitis (MASH) and clinical outcomes . Conference: P32 Toll-like receptor (TLR)5 mediates deleterious effects of lipid injury and fibrogenic responses in metabolic dysfunction-associated steatohepatitis (MASH) and clinical outcomesa29 - a30 .
Li W, Brennan PN, Tavabie OD ( 2024 ) . Letter to the Editor: Future-proofing transplant hepatology training: Shared learnings from “across the pond” . Liver Transplantation vol. 31 , ( 1 ) e1 - e2 .
Chambers ES, Cai W, Vivaldi G, Jolliffe DA, Perdek N, Li W, Faustini SE, Gibbons JM et al. ( 2024 ) . Influence of individuals’ determinants including vaccine type on cellular and humoral responses to SARS-CoV-2 vaccination . npj Vaccines vol. 9 , ( 1 )
Wells G, Spiers J, Williams FR, Li W, Tavabie OD, Brennan PN ( 2024 ) . An overview of the challenges and key initiatives in hepatology practice in the UK in 2022: a cautionary tale, but reasons for optimism – British Association for the Study of the Liver (BASL) Annual Meeting 2022 Conference Report . Clinical Medicine vol. 23 , ( 1 ) 73 - 75 .
Brennan PN, Tavabie OD, Li W, Marjot T, Corless L, Fallowfield JA, Jarvis H, Mansour D et al. ( 2024 ) . Progress is impossible without change: understanding the evolving nomenclature of steatotic liver disease and its effect on hepatology practice . The Lancet Gastroenterology & Hepatology vol. 9 , ( 6 ) 577 - 582 .
Li W, Sheridan D, McPherson S, Alazawi W, Abeysekera K, Marjot T, Brennan P, Mahgoub S et al. ( 2023 ) . National study of NAFLD management identifies variation in delivery of care in the UK between 2019 to 2022 . JHEP Reports vol. 5 , ( 12 )
Li W, Sheridan D, Mcpherson S, Alazawi W ( 2023 ) . THU-447 The national audit of non-alcoholic fatty liver disease (NAFLD) identifies variations and shortfalls in delivery of care in the UK . Journal of Hepatology vol. 78 ,
Li W, Garrido P, Mir IG, Waller K, Jong AV-D, Brindley JH, Khan W, Hood G et al. ( 2023 ) . WED-406 Toll-like receptor 5 signalling mediates pro-inflammatory and fibrogenic responses in non-alcoholic steatohepatitis (NASH) . Journal of Hepatology vol. 78 ,
UK TTCFRAAIH, Tavabie OD, Abeysekera KW, Brennan PN, Marjot T, Kronsten VT, Li W, Nayagam JS et al. ( 2023 ) . Regional variation in characteristics of patients with decompensated cirrhosis admitted to hospitals in the UK . The Lancet Gastroenterology & Hepatology vol. 8 , ( 7 ) 604 - 606 .
Li W, Abbas N, Brennan PN, Mcdowell H, Navaratnam J, Phoolchund A, Scott R, Shearer J et al. ( 2023 ) . UK national trainee survey of hepatology training, research and the future workforce . Frontline Gastroenterology vol. 14 , ( 4 ) 326 - 333 .
Wells G, Spiers J, Williams FR, Li W, Tavabie OD, Brennan PN ( 2023 ) . An overview of the challenges and key initiatives in hepatology practice in the UK in 2022: a cautionary tale, but reasons for optimism - British Association for the Study of the Liver (BASL) Annual Meeting 2022 Conference Report . Clinical Medicine vol. 23 , ( 1 ) 73 - 75 .
Waller KJ, Saihi H, Li W, Brindley JH, De Jong A, Syn W-K, Bessant C, Alazawi W ( 2022 ) . Single-cell phenotypes of peripheral blood immune cells in early and late stages of non-alcoholic fatty liver disease . Clinical and Molecular Hepatology vol. 29 , ( 2 ) 417 - 432 .
Jolliffe DA, Vivaldi G, Chambers ES, Cai W, Li W, Faustini SE, Gibbons JM, Pade C et al. ( 2022 ) . Vitamin D Supplementation Does Not Influence SARS-CoV-2 Vaccine Efficacy or Immunogenicity: Sub-Studies Nested within the CORONAVIT Randomised Controlled Trial . Nutrients vol. 14 , ( 18 )
Vivaldi G, Jolliffe DA, Faustini S, Shields AM, Holt H, Perdek N, Talaei M, Tydeman F et al. ( 2022 ) . Correlation Between Postvaccination Anti-Spike Antibody Titers and Protection Against Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Population-Based Longitudinal Study . Journal of Infectious Diseases vol. 226 , ( 11 ) 1903 - 1908 .
Spiers J, Brindley JH, Li W, Alazawi W ( 2022 ) . What’s new in non-alcoholic fatty liver disease? . Frontline Gastroenterology vol. 13 , ( e1 ) e102 - e108 .
McPherson S, Armstrong MJ, Cobbold JF, Corless L, Anstee QM, Aspinall RJ, Barclay ST, Brennan PN et al. ( 2022 ) . Quality standards for the management of non-alcoholic fatty liver disease (NAFLD): consensus recommendations from the British Association for the Study of the Liver and British Society of Gastroenterology NAFLD Special Interest Group . The Lancet Gastroenterology & Hepatology vol. 7 , ( 8 ) 755 - 769 .
Li W, Kadler BK, Brindley JH, Hood G, Devalia K, Loy J, Syn W-K, Alazawi W ( 2022 ) . The contribution of daytime sleepiness to impaired quality of life in NAFLD in an ethnically diverse population . Scientific Reports vol. 12 , ( 1 )
Kavanagh E, Fernandes L, Li W, Roycroft M, FitzPatrick M ( 2022 ) . Physician trainee research collaboratives: a mixed methods exploration of UK experience . Clinical Medicine vol. 22 , ( 2 ) 119 - 124 .
Usai C, Gibbons JM, Pade C, Li W, Jacobs SRM, McKnight Á, Kennedy PTF, Gill US ( 2022 ) . The β-NGF/TrkA Signalling Pathway Is Associated With the Production of Anti-Nucleoprotein IgG in Convalescent COVID-19 . Frontiers in Immunology vol. 12 ,
Li W, Ng CH, Quek J, Chan KE, Tan C, Zeng RW, Yong JN, Tay H et al. ( 2022 ) . The growing prevalence of nonalcoholic fatty liver disease (NAFLD), determined by fatty liver index, amongst young adults in the United States. A 20-year experience . Metabolism and Target Organ Damage vol. 2 , ( 4 ) null - null .
Li W, Kadler BK, Brindley JH, Berryman V, Preston J, Pattrick M, Sutcliffe C, Hood G et al. ( 2021 ) . Undiagnosed obstructive sleep apnoea is a major component in NAFLD quality of life impairment . JOURNAL OF HEPATOLOGY . vol. 75 , S536 - S537 .
Li W, Alazawi W ( 2020 ) . Non-alcoholic fatty liver disease . Clinical Medicine vol. 20 , ( 5 ) 509 - 512 .
Li W, Kemos P, Salciccioli JD, Marshall DC, Shalhoub J, Alazawi W ( 2020 ) . Socioeconomic Factors Associated With Liver-Related Mortality From 1985 to 2015 in 36 Developed Countries . Clinical Gastroenterology and Hepatology vol. 19 , ( 8 ) 1698 - 1707.e13 .
Li W, Homer K, Hull S, Boomla K, Robson J, Alazawi W ( 2019 ) . Obesity Predicts Liver Function Testing and Abnormal Liver Results . Obesity vol. 28 , ( 1 ) 132 - 138 .
Li W, Britton G, Kudo H, Goldin RD, Alazawi W ( 2019 ) . FRI-279-Stat2 is a pathogenic factor in human non-alcoholic steatohepatitis and mouse models of liver injury and mediates fatty acid-induced Inflammasome activation in hepatocytes . Journal of Hepatology . vol. 70 ,
Waller K, Jong AV-D, Li W, Lowe R, Kemos P, Syn W-K, Alazawi W ( 2019 ) . FRI-356-Single cell peripheral innate and adaptive immune signature of non-alcoholic steatohepatitis by cytometry time of flight . Journal of Hepatology . vol. 70 , e551 - e552 .
Li W, Homer K, Boomla K, Robson J, Hull S, Alazawi W ( 2018 ) . PS-062 Prevalence and explanatory factors for liver function testing and abnormality in a population-based study of children and young people . Journal of Hepatology . vol. 68 , s34 - s35 .
Li W, Chattree A ( 2018 ) . Small-Bowel Obstruction Due to Strongyloides stercoralis Infection . Clinical Gastroenterology and Hepatology vol. 17 , ( 6 ) a41 - a42 .
Li W, Salciccioli JD, Marshall D, Shalhoub J, Alazawi W ( 2018 ) . Factors Influencing Global Trends in Liver-Related Mortality - an Observational Study from 1985 to 2015 . HEPATOLOGY . vol. 68 , 451A - 451A .
De Silva S, Li W, Kemos P, Brindley JH, Mecci J, Samsuddin S, Chin-Aleong J, Feakins RM et al. ( 2017 ) . Non-invasive markers of liver fibrosis in fatty liver disease are unreliable in people of South Asian descent . Frontline Gastroenterology vol. 9 , ( 2 )
De Silva S, Li W, Kemos P, Brindley J, Mecci J, Samsuddin S, Chin-Aleong J, Feakins R et al. ( 2017 ) . PWE-075 Non-invasive markers of liver fibrosis in fatty liver disease are unreliable in people of south asian descent . Gut . Conference: Liver vol. 66 ,
Li W, Kotha S, Joshi D ( 2017 ) . Upper Gastrointestinal Bleeding Caused by Hereditary Hemorrhagic Telangectasia . Clinical Gastroenterology and Hepatology vol. 15 , ( 7 ) a25 - a26 .
De Silva S, Li W, Kemos P, Brindley JH, Feakins R, Chinaleong J, Samsuddin S, Foster GR et al. ( 2017 ) . SAT-320 Blood-test based assessment of liver fibrosis, but not transient elastography, is less accurate in NAFLD patients of South Asian compared to White ethnicity . Journal of Hepatology . vol. 66 , s595 - s596 .
Vivaldi G, Jolliffe DA, Faustini S, Holt H, Perdek N, Talaei M, Tydeman F, Chambers ES et al. . Correlation between post-vaccination titres of combined IgG, IgA, and IgM anti-Spike antibodies and protection against breakthrough SARS-CoV-2 infection: a population-based longitudinal study (COVIDENCE UK) .
Chambers ES, Cai W, Vivaldi G, Jolliffe DA, Perdek N, Li W, Faustini SE, Gibbons JM et al. . Influence of age, sex, body habitus, vaccine type and anti-S serostatus on cellular and humoral responses to SARS-CoV-2 vaccination .
Jolliffe DA, Vivaldi G, Chambers ES, Cai W, Li W, Faustini SE, Gibbons JM, Pade C et al. . Influence of vitamin D supplementation on SARS-CoV-2 vaccine efficacy and immunogenicity .
Usai C, Gibbons JM, Pade C, Li W, Jacobs SRM, McKnight Á, Kennedy PTF, Gill US . The β-NGF/TrkA signalling pathway is associated with the production of anti- nucleoprotein IgG in convalescent COVID-19 .
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