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Research
  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: DR Barrie Peck

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( 2025 ) . LIMD1 Loss Confers a GPX4-Dependent Cell State in Lung Cancer .
( 2024 ) . <i>CREBBP</i> histone acetyltransferase domain mutations predict response to mTOR inhibition in relapsed/refractory follicular lymphoma . British Journal of Haematology vol. 205 , ( 5 ) 1804 - 1809 .
( 2024 ) . Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation . Leukemia vol. 38 , ( 11 ) 2395 - 2409 .
( 2023 ) . Abstract B020: <i>SF3B1 </i>hotspot mutations confer sensitivity to PARP inhibition through a defective replication stress response . Molecular Cancer Therapeutics vol. 22 , ( 12_Supplement ) B020 - B020 .
( 2023 ) . SCD inhibition preferentially eradicates AML displaying high de novo fatty acid desaturation and synergizes with chemotherapy .
( 2023 ) . SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response . Nature Genetics vol. 55 , ( 8 ) 1311 - 1323 .
( 2023 ) . TGFβ-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progression . npj Breast Cancer vol. 9 , ( 1 ) Article 9 ,
( 2023 ) . Abstract P6-10-05: Mutations in the RNA Splicing Factor SF3B1 drive endocrine therapy resistance and confer a targetable replication stress response defect through PARP inhibition . Cancer Research vol. 83 , ( 5_Supplement )
( 2022 ) . Inhibition of Stearoyl-CoA Desaturase Has Anti-Leukemic Properties in Acute Myeloid Leukemia . Blood vol. 140 , ( Supplement 1 ) 3058 - 3060 .
( 2021 ) . Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence . Nature Communications vol. 12 , ( 1 ) Article 5507 ,
( 2021 ) . 3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer . Cancer Research vol. 81 , ( 4 ) 847 - 859 .
( 2020 ) . A micronutrient with major effects on cancer cell viability . Nature Metabolism vol. 2 , ( 7 ) 564 - 565 .
( 2019 ) . Lipid Metabolism at the Nexus of Diet and Tumor Microenvironment . Trends in Cancer vol. 5 , ( 11 ) 693 - 703 .
( 2019 ) . 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers . Molecular Cancer Therapeutics vol. 18 , ( 2 ) 376 - 388 .
( 2018 ) . Abstract 788: Modeling tumor microenvironmental heterogeneity identifies CREBBP as a novel tumor suppressor in breast cancer . Cancer Research vol. 78 , ( 13_Supplement ) 788 - 788 .
( 2018 ) . The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma . Oncogene vol. 37 , ( 40 ) 5435 - 5450 .
( 2017 ) . Identification and Validation of Driver Kinases from Next-Generation Sequencing Data . 179 - 195 .
( 2017 ) . Abstract NTOC-093: SYNTHETIC LETHAL APPROACHES TO TARGET ARID1A DEFICIENT OVARIAN CANCERS . Clinical Cancer Research vol. 23 , ( 11_Supplement )
( 2016 ) . Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures . Journal of Visualized Experiments ( 118 )
( 2016 ) . Three‐dimensional modelling identifies novel genetic dependencies associated with breast cancer progression in the isogenic<scp>MCF10</scp>model . The Journal of Pathology vol. 240 , ( 3 ) 315 - 328 .
( 2016 ) . Functional assessment of low-frequency mutations in breast cancer . European Journal of Cancer vol. 61 , S17 - S17 .
( 2016 ) . Modelling the tumour microenvironment and employing functional genomics identifies CREBBP as a novel tumour suppressor in triple negative breast cancers . European Journal of Cancer vol. 61 , S73 - S74 .
( 2016 ) . Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments . Cancer &amp; Metabolism vol. 4 , ( 1 ) Article 6 ,
( 2016 ) . Lipid desaturation – the next step in targeting lipogenesis in cancer? . The FEBS Journal vol. 283 , ( 15 ) 2767 - 2778 .
( 2016 ) . Abstract PR06: Modeling the tumor microenvironment to identify novel loss of function mutations in breast cancer progression . Molecular Cancer Research vol. 14 , ( 2_Supplement ) PR06 - PR06 .
( 2015 ) . SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme . Oncogene vol. 34 , ( 40 ) 5128 - 5140 .
( 2015 ) . Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress . Cancer Cell vol. 27 , ( 1 ) 57 - 71 .
( 2014 ) . Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation . Cell Reports vol. 9 , ( 1 ) 349 - 365 .
( 2014 ) . Acetyl-coA synthetase 2 promotes acetate utilization and maintains cell growth under metabolic stress . Cancer &amp; Metabolism vol. 2 , ( S1 ) Article O9 ,
( 2014 ) . Cholesteryl Esters: Fueling the Fury of Prostate Cancer . Cell Metabolism vol. 19 , ( 3 ) 350 - 352 .
( 2013 ) . Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development . Disease Models &amp; Mechanisms vol. 6 , ( 6 ) 1353 - 1363 .
( 2013 ) . Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth . Cancer &amp; Metabolism vol. 1 , ( 1 ) Article 3 ,
( 2013 ) . Antagonism between FOXO and MYC Regulates Cellular Powerhouse . Frontiers in Oncology vol. 3 ,
( 2011 ) . FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression . Cell Death &amp; Differentiation vol. 19 , ( 6 ) 968 - 979 .
( 2011 ) . A role for the cancer-associated miR-106b~25 cluster in neuronal stem cells . Aging vol. 3 , ( 4 ) 329 - 331 .
( 2010 ) . SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2 . Molecular Cancer Therapeutics vol. 9 , ( 4 ) 844 - 855 .
( 2010 ) . FOXM1 Confers Acquired Cisplatin Resistance in Breast Cancer Cells . Molecular Cancer Research vol. 8 , ( 1 ) 24 - 34 .
( 2009 ) . FoxM1 is a downstream target and marker of HER2 overexpression in breast cancer . INT J ONCOL vol. 35 , ( 1 ) 57 - 68 .
( 2009 ) . Gefitinib (Iressa) represses FOXM1 expression via FOXO3a in breast cancer . MOL CANCER THER vol. 8 , ( 3 ) 582 - 591 .
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