Publications: PROF Philip Eaton

Burgoyne JR, Eaton P ( 2025 ) . Cysteine-based redox sensors in the cardiovascular system: from identification to physiology and drug discovery . Physiological Reviews vol. 105 , ( 4 ) 2033 - 2072 .

Sudhahar V, Abdelsaid K, Eaton P, Kelley S, Ushio-Fukai M, Fukai T ( 2025 ) . Exercise-Induced SOD3/H\n ₂\n O\n ₂\n Sulfenylates PKG1α to Restore Vasodilation in Diabetes . Circulation Research vol. 137 , ( 3 ) 449 - 452 .

Cho H-J, Smith J, Switzer CH, Louka E, Charles RL, Prysyazhna O, Schroder E, Fernandez-Caggiano M et al. ( 2025 ) . SFX-01 is therapeutic against myeloproliferative disorders caused by activating mutations in Shp2 . EMBO Molecular Medicine vol. 17 , ( 8 ) 2115 - 2136 .

Simoes de Jesus D, Buffonge S, Abis G, Buccafusca R, Baliga R, Warren HR, Hobbs A, Ruppert C et al. ( 2025 ) . Zinc-mediated Inhibition of Soluble Epoxide Hydrolase Promotes Pulmonary Hypertension . American Journal of Respiratory and Critical Care Medicine Article rccm.202409-1763OC ,

Green HLH, Rasetta A, Eaton P, Kaur M, Rudyk O ( 2025 ) . Investigating the role of protein kinase a regulatory subunit PKARIα in pulmonary hypertension . Free Radical Biology and Medicine vol. 233 , S33 - S33 .

Francois AA, Yin X, Oka S, Sadoshima J, Mayr M, Eaton P ( 2025 ) . On the utility of immobilized phenylarsine oxide in the study of redox sensitive cardiac proteins . Scientific Reports vol. 15 , ( 1 ) Article 15554 ,

Simoes de Jesus D, Buffonge S, Abis G, Buccafusca R, Baliga R, Warren HR, Hobbs A, Ruppert C et al. ( 2024 ) . Zinc-mediated inhibition of soluble epoxide hydrolase promotes pulmonary hypertension . Free Radical Biology and Medicine vol. 224 , S58 - S58 .

Knight H, Abis G, Kaur M, Green HLH, Krasemann S, Hartmann K, Lynham S, Clark J et al. ( 2023 ) . Cyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular Cell Proliferation . Circulation Research vol. 133 , ( 12 ) 966 - 988 .

Heusch G, Andreadou I, Bell R, Bertero E, Botker H-E, Davidson SM, Downey J, Eaton P et al. ( 2023 ) . Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection . Redox Biology vol. 67 , Article 102894 , 102894 - 102894 .

Caggiano MF, Charles R, Prysyazhna O, Eaton P ( 2023 ) . UK-5099 does not inhibit the mitochondrial pyruvate carrier through irreversible adduction to cysteine 54 in MPC2 . Free Radical Biology and Medicine vol. 208 , S66 - S66 .

Rudyk O, Prysyazhna O, Eaton P ( 2023 ) . BS17 Oxidation of protein kinase a regulatory subunit PKARIα alpha regulates vasodilation and blood pressure lowering . Basic Science . Conference: British Cardiovascular Society Annual Conference, ‘Future-proofing Cardiology for the next 10 years’, 5–7 June 2023

Switzer CH, Kasamatsu S, Ihara H, Eaton P ( 2023 ) . SOD1 is an essential H\n ₂\n S detoxifying enzyme . Proceedings of the National Academy of Sciences vol. 120 , ( 3 ) Article e2205044120 ,

Kamynina A, Guttzeit S, Eaton P, Cuello F ( 2022 ) . Blood pressure lowering by nitroxyl donor CXL-1020 is mediated by oxidation of Protein Kinase G I . Journal of Molecular and Cellular Cardiology vol. 173 , S96 - S97 .

Varadarajan S, Abdelsaid K, Boatwright H, McMenamin M, Eaton P, Ushio-Fukai M, Fukai T ( 2022 ) . Abstract 9930: Exercise-Induced ATP7A, A Cu Transporter for SOD3, Restores Endothelial Dysfunction in Type2 Diabetes via Cysteine Oxidation of Protein Kinase G . Circulation vol. 146 , ( Suppl_1 )

Charles R, Fernandez-Caggiano M, Rudyk O, Ehteramyan M, Switzer C, Buccafusca R, Bianchi K, Morales V et al. ( 2022 ) . A novel inhibitor of soluble Epoxide Hydrolase that adducts C521 is cardioprotective . Free Radical Biology and Medicine vol. 192 , 56 - 56 .

Francois AA, Yin X, Mayr M, Eaton P ( 2022 ) . Identification of Cardiac Proteins that Sense Oxidants by Intra-disulfide Formation . Free Radical Biology and Medicine vol. 192 , 60 - 61 .

Baidanoff FM, Trebucq LL, Plano SA, Eaton P, Golombek DA, Chiesa JJ ( 2022 ) . Cysteine Oxidation Promotes Dimerization/Oligomerization of Circadian Protein Period 2 . Biomolecules vol. 12 , ( 7 ) 892 - 892 .

Charles R, Eaton P ( 2022 ) . Redox Regulation of Soluble Epoxide Hydrolase—Implications for Cardiovascular Health and Disease . Cells vol. 11 , ( 12 ) 1932 - 1932 .

Switzer CH, Cho H-J, Eykyn TR, Lavender P, Eaton P ( 2022 ) . NOS2 and <i>S</i>-nitrosothiol signaling induces DNA hypomethylation and LINE-1 retrotransposon expression . Proceedings of the National Academy of Sciences of the United States of America vol. 119 , ( 21 )

Switzer CH, Cho H-J, Eykyn TR, Lavender P, Eaton P ( 2022 ) . NOS2 and\n <i>S</i>\n -nitrosothiol signaling induces DNA hypomethylation and LINE-1 retrotransposon expression . Proceedings of the National Academy of Sciences vol. 119 , ( 21 ) Article e2200022119 ,

Kamynina A, Guttzeit S, Eaton P, Cuello F ( 2022 ) . Nitroxyl Donor CXL-1020 Lowers Blood Pressure by Targeting C195 in Cyclic Guanosine-3’,5’-Monophosphate-Dependent Protein Kinase I . Hypertension vol. 79 , ( 5 ) 946 - 956 .

Nishiyama K, Nishimura A, Shimoda K, Tanaka T, Kato Y, Shibata T, Tanaka H, Kurose H et al. ( 2022 ) . Redox-dependent internalization of the purinergic P2Y\n ₆\n receptor limits colitis progression . Science Signaling vol. 15 , ( 716 ) Article eabj0644 ,

Varadarajan S, Abdelsaid K, Boatwright H, McMenamin M, Eaton P, Ushio-Fukai M, Fukai T ( 2022 ) . Exercise-Induced ATP7A, A Cu Transporter for SOD3, Restores Endothelial Dysfunction in Type2 Diabetes via Cysteine Oxidation of Protein Kinase G . CIRCULATION . vol. 146 ,

Queiroz RF, Stanley CP, Wolhuter K, Kong SMY, Rajivan R, McKinnon N, Nguyen GTH, Roveri A et al. ( 2021 ) . Hydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation . Nature Communications vol. 12 , ( 1 ) Article 6626 ,

Switzer CH, Guttzeit S, Eykyn TR, Eaton P ( 2021 ) . Cysteine trisulfide oxidizes protein thiols and induces electrophilic stress in human cells . Redox Biology vol. 47 , Article 102155 , 102155 - 102155 .

Islam MMT, Tarnowski D, Zhang M, Trum M, Lebek S, Mustroph J, Daniel H, Moellencamp J et al. ( 2021 ) . Enhanced Heart Failure in Redox‐Dead Cys17Ser PKARIα Knock‐In Mice . Journal of the American Heart Association vol. 10 , ( 19 ) Article e021985 ,

Charles RL, Abis G, Fernandez BF, Guttzeit S, Buccafusca R, Conte MR, Eaton P ( 2021 ) . A thiol redox sensor in soluble epoxide hydrolase enables oxidative activation by intra-protein disulfide bond formation . Redox Biology vol. 46 , Article 102107 , 102107 - 102107 .

Simon JN, Vrellaku B, Monterisi S, Chu SM, Rawlings N, Lomas O, Marchal GA, Waithe D et al. ( 2021 ) . Oxidation of Protein Kinase A Regulatory Subunit PKARIα Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Lysosomal-Triggered Calcium Release . Circulation vol. 143 , ( 5 ) 449 - 465 .

Fernandez-Caggiano M, Eaton P ( 2021 ) . Heart failure—emerging roles for the mitochondrial pyruvate carrier . Cell Death &amp; Differentiation vol. 28 , ( 4 ) 1149 - 1158 .

Trum M, Islam MMT, Lebek S, Baier M, Hegner P, Eaton P, Maier LS, Wagner S ( 2020 ) . Inhibition of cardiac potassium currents by oxidation-activated protein kinase A contributes to early afterdepolarizations in the heart . American Journal of Physiology-Heart and Circulatory Physiology vol. 319 , ( 6 ) H1347 - H1357 .

Simon JN, VRELLAKU B, Monterisi S, Chu S, Rawlings N, Lomas O, Marchal GA, Waithe D et al. ( 2020 ) . Abstract 14219: Oxidation of PKA-RIα Protects Against Ischemia-reperfusion Injury by Inhibiting Lysosomal-triggered Calcium Release . Circulation vol. 142 , ( Suppl_3 )

Fernandez-Caggiano M, Kamynina A, Francois AA, Prysyazhna O, Eykyn TR, Krasemann S, Crespo-Leiro MG, Vieites MG et al. ( 2020 ) . Mitochondrial pyruvate carrier abundance mediates pathological cardiac hypertrophy . Nature Metabolism vol. 2 , ( 11 ) 1223 - 1231 .

Simon JN, Vrellaku B, Monterisi S, Chu S, Rawlings N, Lomas O, Marchal GA, Waithe D et al. ( 2020 ) . B Oxidized PKARIα protects against ischemia-reperfusion injury by inhibiting lysosomal-triggered calcium release . Young Investigators AwardA111.2 - A111 .

Wack G, Eaton P, Schmidtko A, Kallenborn-Gerhardt W ( 2020 ) . Redox regulation of soluble epoxide hydrolase does not affect pain behavior in mice . Neuroscience Letters vol. 721 , Article 134798 , 134798 - 134798 .

Cho H-J, Switzer CH, Kamynina A, Charles R, Rudyk O, Ng T, Burgoyne JR, Eaton P ( 2020 ) . Complex interrelationships between nitro-alkene-dependent inhibition of soluble epoxide hydrolase, inflammation and tumor growth . Redox Biology vol. 29 , Article 101405 , 101405 - 101405 .

Tarnowski D, Islam MMT, Trum M, Eaton P, Maier LS, Wagner S, Sag CM ( 2020 ) . Redox-activated protein kinase A Type I (PKA RI) exerts a protective role during pathological pressure overload . EUROPEAN HEART JOURNAL . vol. 41 , 3679 - 3679 .

Csato V, Kadir SZSA, Khavandi K, Bennett H, Sugden S, Gurney AM, Pritchard HAT, Hill‐Eubanks D et al. ( 2019 ) . “A Step and a Ceiling”: mechanical properties of Ca\n ²⁺\n spark vasoregulation in resistance arteries by pressure‐induced oxidative activation of PKG . Physiological Reports vol. 7 , ( 22 )

Prysyazhna O, Wolhuter K, Switzer C, Santos C, Yang X, Lynham S, Shah AM, Eaton P et al. ( 2019 ) . Response by Prysyazhna et al to Letter Regarding Article, “Blood Pressure–Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase” . Circulation vol. 140 , ( 22 )

Feelisch M, Akaike T, Griffiths K, Ida T, Prysyazhna O, Goodwin JJ, Gollop ND, Fernandez BO et al. ( 2019 ) . Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides, and oxidation of protein kinase G1α redox signalling . Cardiovascular Research vol. 116 , ( 1 ) 51 - 62 .

Prysyazhna O, Wolhuter K, Switzer C, Santos C, Yang X, Lynham S, Shah AM, Eaton P et al. ( 2019 ) . Blood Pressure–Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase . Circulation vol. 140 , ( 2 ) 126 - 137 .

Rudyk O, Rowan A, Prysyazhna O, Krasemann S, Hartmann K, Zhang M, Shah AM, Ruppert C et al. ( 2019 ) . Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension . Proceedings of the National Academy of Sciences vol. 116 , ( 26 ) 13016 - 13025 .

Dunham-Snary KJ, Wu D, Potus F, Sykes EA, Mewburn JD, Charles RL, Eaton P, Sultanian RA et al. ( 2019 ) . Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction . Circulation Research vol. 124 , ( 12 ) 1727 - 1746 .

Abis G, Charles RL, Kopec J, Yue WW, Atkinson RA, Bui TTT, Lynham S, Popova S et al. ( 2019 ) . 15-deoxy-Δ12,14-Prostaglandin J2 inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism . Communications Biology vol. 2 , ( 1 ) Article 188 ,

Stanley CP, Maghzal GJ, Ayer A, Talib J, Giltrap AM, Shengule S, Wolhuter K, Wang Y et al. ( 2019 ) . Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation . Nature vol. 566 , ( 7745 ) 548 - 552 .

Cuello F, Eaton P ( 2019 ) . Cysteine-Based Redox Sensing and Its Role in Signaling by Cyclic Nucleotide–Dependent Kinases in the Cardiovascular System . Annual Reviews

Duraffourd C, Huckstepp RTR, Braren I, Fernandes C, Brock O, Delogu A, Prysyazhna O, Burgoyne J et al. ( 2019 ) . PKG1α oxidation negatively regulates food seeking behaviour and reward . Redox Biology vol. 21 , Article 101077 , 101077 - 101077 .

Abis G, Charles RL, Eaton P, Conte MR ( 2019 ) . Expression, purification, and characterisation of human soluble Epoxide Hydrolase (hsEH) and of its functional C-terminal domain . Protein Expression and Purification vol. 153 , 105 - 113 .

Simon JN, Vrellaku B, Monterisi S, Chu S, Rawlings N, Lomas O, Marchal GA, Waithe D et al. ( 2019 ) . Redox-mediated PKA-RIalpha localisation to the lysosome inhibits myocardial calcium release and robustly reduces myocardial injury . EUROPEAN HEART JOURNAL . vol. 40 , 1266 - 1266 .

Smith J, Schroder E, Prysyazhna O, Cho H, Mayr M, Eaton P ( 2018 ) . Sulforaphane-mediated inhibition of SHP2 as a potential pharmacotherapy for Noonan syndrome . Free Radical Biology and Medicine . vol. 128 , S42 - S42 .

Cuello F, Wittig I, Lorenz K, Eaton P ( 2018 ) . Oxidation of cardiac myofilament proteins: Priming for dysfunction? . Molecular Aspects of Medicine vol. 63 , 47 - 58 .

De Nicola GF, Bassi R, Nichols C, Fernandez-Caggiano M, Golforoush PA, Thapa D, Anderson R, Martin ED et al. ( 2018 ) . The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules . JCI Insight vol. 3 , ( 16 ) Article e121144 ,

Stocker R ( 2018 ) . Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation . Free Radical Biology and Medicine . vol. 120 , S10 - S11 .

Wolhuter K, Whitwell HJ, Switzer CH, Burgoyne JR, Timms JF, Eaton P ( 2018 ) . Evidence against Stable Protein S-Nitrosylation as a Widespread Mechanism of Post-translational Regulation . Molecular Cell vol. 69 , ( 3 ) 438 - 450.e5 .

Towhidul Islam MM, Eaton P, Maier L, Wagner S ( 2017 ) . Modulation of Cardiac Function by Oxidized Type I Protein Kinase A . Free Radical Biology and Medicine . vol. 112 , 123 - 124 .

Todd Milne G, Sandner P, Lincoln KA, Harrison PC, Chen H, Wang H, Clifford H, Qian HS et al. ( 2017 ) . Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications . BMC Pharmacology and Toxicology vol. 18 , ( S1 ) Article 64 ,

Rudyk O, Eaton P ( 2017 ) . Examining a role for PKG Iα oxidation in the pathogenesis of cardiovascular dysfunction during diet-induced obesity . Free Radical Biology and Medicine vol. 110 , 390 - 398 .

Burgoyne JR, Prysyazhna O, Richards DA, Eaton P ( 2017 ) . Proof of Principle for a Novel Class of Antihypertensives That Target the Oxidative Activation of PKG Iα (Protein Kinase G Iα) . Hypertension vol. 70 , ( 3 ) 577 - 586 .

Bassi R, Burgoyne JR, DeNicola GF, Rudyk O, DeSantis V, Charles RL, Eaton P, Marber MS ( 2017 ) . Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3 . Journal of Biological Chemistry vol. 292 , ( 39 ) 16161 - 16173 .

Donzelli S, Goetz M, Schmidt K, Wolters M, Stathopoulou K, Diering S, Prysyazhna O, Polat V et al. ( 2017 ) . Oxidant sensor in the cGMP-binding pocket of PKGIα regulates nitroxyl-mediated kinase activity . Scientific Reports vol. 7 , ( 1 ) Article 9938 ,

Wolhuter K, Eaton P ( 2017 ) . How widespread is stable protein S-nitrosylation as an end-effector of protein regulation? . Free Radical Biology and Medicine vol. 109 , 156 - 166 .

Sag CM, Schnelle M, Zhang J, Murdoch CE, Kossmann S, Protti A, Santos CXC, Sawyer G et al. ( 2017 ) . Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell NAPDH Oxidase 2 on Blood Pressure . Circulation vol. 135 , ( 22 ) 2163 - 2177 .

Valek L, Häussler A, Dröse S, Eaton P, Schröder K, Tegeder I ( 2017 ) . Redox-guided axonal regrowth requires cyclic GMP dependent protein kinase 1: Implication for neuropathic pain . Redox Biology vol. 11 , 176 - 191 .

Diering S, Goetz M, Schobesberger S, Stathopoulou K, Piasecki A, Nikolaev VO, Eaton P, Cuello F ( 2017 ) . Exposure of adult rat ventricular myocytes to nitroxyl induces activation of cAMP-dependent protein kinase through interdisulfide formation and substrate targeting . JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY . vol. 109 , 34 - 35 .

Goetz M, Donzelli S, Schmidt K, Wolters M, Stathopoulou K, Prysyazhna O, Scotcher J, Dees C et al. ( 2017 ) . Nitroxyl mediates vasodilation by inducing an activating intradisulfide bond in the high affinity cGMP-binding site of PKGIα . JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY . vol. 109 , 38 - 38 .

Rudyk O, Krasemann S, Hartmann K, Prysyazhna O, Zhang M, Weiss A, Zhao L, Schermuly R et al. ( 2017 ) . PKGIα oxidation during chronic hypoxia provides an adaptive vasodilatory mechanism that limits pulmonary hypertension . JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY . vol. 109 , 9 - 9 .

Cowan J, Longman MR, Eaton P, Snabaitis AK ( 2017 ) . Regulation of cardiomyocyte DNA damage and apoptosis by the type 2A protein phosphatase regulatory protein alpha4 . JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY . vol. 109 , 51 - 51 .

Schulz S, Prysyazhna O, Eaton P, Cuello F ( 2017 ) . Revealing transcriptomic changes in response to chronic angiotensin II infusion in atria versus ventricles of the mouse by nanostring analysis . JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY . vol. 109 , 25 - 26 .

Wolhuter K, Burgoyne JR, Eaton P ( 2016 ) . Are S-Nitrosothiols Predominantly Stable End-Effectors of Protein Function or Transient Intermediates Leading to Disulfide Formation? . Free Radical Biology and Medicine . vol. 100 , S47 - S48 .

Prysyazhna O, Scotcher J, Boguslavskyi A, Kistamas K, Hadgraft N, Martin ED, Worthington J, Rudyk O et al. ( 2016 ) . Redox Control of Protein Kinase G Iα Fine-Tunes the Frank-Starling Law of the Heart in Vivo by Regulating Diastolic Relaxation . Free Radical Biology and Medicine . vol. 100 , S148 - S148 .

Maghzal GJ, Stanley C, Shengule S, Giltrap AM, Chadha PC, Prysyazhna S, Prado FM, Yamamoto Y et al. ( 2016 ) . Regulation of Vascular Tone and Blood Pressure by a Tryptophan-Derived Tricyclic Hydroperoxide . Free Radical Biology and Medicine . vol. 100 , S46 - S46 .

Scotcher J, Prysyazhna O, Boguslavskyi A, Kistamas K, Hadgraft N, Martin ED, Worthington J, Rudyk O et al. ( 2016 ) . Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank–Starling response . Nature Communications vol. 7 , ( 1 ) Article 13187 ,

Khavandi K, Baylie RL, Sugden SA, Ahmed M, Csato V, Eaton P, Hill-Eubanks DC, Bonev AD et al. ( 2016 ) . Pressure-induced oxidative activation of PKG enables vasoregulation by Ca\n ²⁺\n sparks and BK channels . Science Signaling vol. 9 , ( 449 )

Prysyazhna O, Burgoyne JR, Scotcher J, Grover S, Kass D, Eaton P ( 2016 ) . Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G Iα Oxidation . Journal of Biological Chemistry vol. 291 , ( 33 ) 17427 - 17436 .

Fernandez-Caggiano M, Schröder E, Cho H-J, Burgoyne J, Barallobre-Barreiro J, Mayr M, Eaton P ( 2016 ) . Oxidant-induced Interprotein Disulfide Formation in Cardiac Protein DJ-1 Occurs via an Interaction with Peroxiredoxin 2 . Journal of Biological Chemistry vol. 291 , ( 19 ) 10399 - 10410 .

Stathopoulou K, Wittig I, Heidler J, Piasecki A, Richter F, Diering S, Velden J, Buck F et al. ( 2016 ) . <i>S</i>‐glutathiolation impairs phosphoregulation and function of cardiac myosin‐binding protein C in human heart failure . The FASEB Journal vol. 30 , ( 5 ) 1849 - 1864 .

Akashi S, Ahmed KA, Sawa T, Ono K, Tsutsuki H, Burgoyne JR, Ida T, Horio E et al. ( 2016 ) . Persistent Activation of cGMP-Dependent Protein Kinase by a Nitrated Cyclic Nucleotide via Site Specific Protein <i>S</i>-Guanylation . Biochemistry vol. 55 , ( 5 ) 751 - 761 .

Fernández-Caggiano M, Prysyazhna O, Barallobre-Barreiro J, CalviñoSantos R, Aldama López G, Generosa Crespo-Leiro M, Eaton P, Doménech N ( 2016 ) . Analysis of Mitochondrial Proteins in the Surviving Myocardium after Ischemia Identifies Mitochondrial Pyruvate Carrier Expression as Possible Mediator of Tissue Viability . Molecular &amp; Cellular Proteomics vol. 15 , ( 1 ) 246 - 255 .

Trum M, Zitron E, Eaton P, Maier LS, Wagner S ( 2016 ) . Reactive oxygen specied inhibit inward rectifying K current by redox-activated protein kinase A . EUROPEAN HEART JOURNAL . vol. 37 , 894 - 895 .

Mistry RK, Murray TVA, Prysyazhna O, Martin D, Burgoyne JR, Santos C, Eaton P, Shah AM et al. ( 2016 ) . Transcriptional Regulation of Cystathionine-γ-Lyase in Endothelial Cells by NADPH Oxidase 4-Dependent Signaling . Journal of Biological Chemistry vol. 291 , ( 4 ) 1774 - 1788 .

Kohl T, Weninger G, Zalk R, Eaton P, Lehnart SE ( 2015 ) . Intensity matters: Ryanodine receptor regulation during exercise . Proceedings of the National Academy of Sciences vol. 112 , ( 50 ) 15271 - 15272 .

Rudyk O, Prysyazhna O, Zhao L, Eaton P ( 2015 ) . Evaluating a possible role for PKG1α redox state in chronic hypoxia-induced pulmonary hypertension . BMC Pharmacology and Toxicology vol. 16 , ( S1 ) Article A80 ,

Prysyazhna O, Burgoyne JR, Eaton P ( 2015 ) . Tadalafil protects from doxorubicin-induced heart failure by attenuating PKG Iα disulfide dimerisation . BMC Pharmacology and Toxicology vol. 16 , ( S1 ) Article A75 ,

Burgoyne JR, Rudyk O, Cho H-J, Prysyazhna O, Hathaway N, Weeks A, Evans R, Ng T et al. ( 2015 ) . Deficient angiogenesis in redox-dead Cys17Ser PKARIα knock-in mice . Nature Communications vol. 6 , ( 1 ) Article 7920 ,

Prysyazhna O, Eaton P ( 2015 ) . Redox regulation of cGMP-dependent protein kinase Iα in the cardiovascular system . Frontiers in Pharmacology vol. 6 ,

Cameron JM, Gabrielsen M, Chim YH, Munro J, McGhee EJ, Sumpton D, Eaton P, Anderson KI et al. ( 2015 ) . Polarized Cell Motility Induces Hydrogen Peroxide to Inhibit Cofilin via Cysteine Oxidation . Current Biology vol. 25 , ( 11 ) 1520 - 1525 .

Nakamura T, Ranek MJ, Lee DI, Shalkey Hahn V, Kim C, Eaton P, Kass DA ( 2015 ) . Prevention of PKG1α oxidation augments cardioprotection in the stressed heart . Journal of Clinical Investigation vol. 125 , ( 6 ) 2468 - 2472 .

Eaton P ( 2015 ) . Thiol redox sensing and signalling and the control of blood pressure . Nitric Oxide . vol. 47 , S6 - S7 .

Khavandi K, Baylie R, Ahmed M, Sugden S, Eaton P, Nelson MT, Greenstein A ( 2015 ) . PKG-I[[Unable to Display Character: &]] Oxidative Activation Regulates Small Artery Myogenic Tone Through Calcium Sparks and the BK Channel . CIRCULATION . vol. 132 ,

Stubbert D, Prysyazhna O, Rudyk O, Scotcher J, Burgoyne JR, Eaton P ( 2014 ) . Protein Kinase G Iα Oxidation Paradoxically Underlies Blood Pressure Lowering by the Reductant Hydrogen Sulfide . Hypertension vol. 64 , ( 6 ) 1344 - 1351 .

Sawa T, Ahmed A, Ono K, Ida T, Fujii S, Eaton P, Akaike T ( 2014 ) . Persistent activation of protein kinase G by a nitrated cyclic nucleotide via site specific S-guanylation and its implication for vascular hyporeactivity in endotoxin shock . Nitric Oxide . vol. 42 , 140 - 140 .

Wolhuter K, Robert Burgoyne J, Eaton P ( 2014 ) . Protein S-Nitrosation Is Primarily a Transient Intermediate Leading to Disulfide Formation . Free Radical Biology and Medicine . vol. 76 , S18 - S19 .

Lorenz JE, Kallenborn-Gerhardt W, Lu R, Syhr KMJ, Eaton P, Geisslinger G, Schmidtko A ( 2014 ) . Oxidant-Induced Activation of cGMP-Dependent Protein Kinase Iα Mediates Neuropathic Pain After Peripheral Nerve Injury . Antioxidants &amp; Redox Signaling vol. 21 , ( 10 ) 1504 - 1515 .

Eaton P, Shah AM ( 2014 ) . Preface for redox signalling in the cardiovascular system . Journal of Molecular and Cellular Cardiology vol. 73 , 1 - 1 .

Charles RL, Rudyk O, Prysyazhna O, Kamynina A, Yang J, Morisseau C, Hammock BD, Freeman BA et al. ( 2014 ) . Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase . Proceedings of the National Academy of Sciences vol. 111 , ( 22 ) 8167 - 8172 .

Charles R, Jayawardhana T, Eaton P ( 2014 ) . Gel-based methods in redox proteomics . Biochimica et Biophysica Acta (BBA) - General Subjects vol. 1840 , ( 2 ) 830 - 837 .

Bassi R, Rudyk O, Burgoyne J, Eaton P, Marber MS ( 2014 ) . 3 Can Redox-Sensitive Cysteines in P38A-MAPK Modulate Activation During Stress? . Heart . vol. 100 , A2.3 - A2 .

Rudyk O, Eaton P ( 2014 ) . Biochemical methods for monitoring protein thiol redox states in biological systems . Redox Biology vol. 2 , 803 - 813 .

Islam T, Dantz C, Daniel H, Moellencamp J, El-Armouche A, Eaton P, Maier LS, Wagner S ( 2014 ) . Disruption of oxidative PKA activation contributes to ventricular remodeling upon increased afterload . EUROPEAN HEART JOURNAL . vol. 35 , 330 - 330 .

Kallenborn-Gerhardt W, Lorenz JE, Lu R, Eaton P, Geisslinger G, Schmidtko A ( 2014 ) . Oxidant-induced activation of cGMP-dependent protein kinase Iα contributes to neuropathic pain processing after nerve injury . NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY . vol. 387 , S55 - S55 .

Ranek MJ, Nakamura T, Holewinski R, Lee D-I, Zhu G, Chakir K, Eaton P, Van Eyk J et al. ( 2014 ) . Protein Kinase G Oxidation Blunts Its Suppression of Cardiac Hypertrophy by Diminishing Phosphorylation of Tuberin and Consequent Autophagy . CIRCULATION . vol. 130 ,

Hohl M, Ardehali H, Azuaje FJ, Breckenridge RA, Doehner W, Eaton P, Ehret GB, Fujita T et al. ( 2013 ) . Meeting highlights from the 2013 <scp>E</scp>uropean <scp>S</scp>ociety of <scp>C</scp>ardiology <scp>H</scp>eart <scp>F</scp>ailure <scp>A</scp>ssociation <scp>W</scp>inter <scp>M</scp>eeting on <scp>T</scp>ranslational <scp>H</scp>eart <scp>F</scp>ailure <scp>R</scp>esearch . European Journal of Heart Failure vol. 16 , ( 1 ) 6 - 14 .

Prysyazhna O, Robert Burgoyne J, Philip Eaton P ( 2013 ) . Cys42Ser PKG Iα Mutant Mice Are Protected from Doxorubicin-Induced Cardiomyopathy . Free Radical Biology and Medicine . vol. 65 , S80 - S81 .

Charles RL, Rudyk O, Prysyazhna O, Yang J, Morisseau C, Hammock B, Freeman B, Eaton P ( 2013 ) . Loss of Redox Regulation in Cys521Ser Soluble Epoxide Hydrolase Knock-In Mice Results in Hypertension and Hypertrophy . Free Radical Biology and Medicine . vol. 65 , S69 - S69 .

Burgoyne JR, Rudyk O, Prysyazhna O, Schröder K, Brandes RP, Shah AM, Eaton P ( 2013 ) . Oxidation of Camp Dependent Protein Kinase Regulatory RIα Mediates Angiogenesis . Free Radical Biology and Medicine . vol. 65 , S68 - S68 .

Rudyk O, Prysyazhna O, Eaton P ( 2013 ) . Redox-Dead Protein Kinase a RIα knock-in Mouse Is Not Hypertensive But Has Increased Vascular Reactivity to Oxidants . Free Radical Biology and Medicine . vol. 65 , S82 - S82 .

Stubbert D, Prysyazhna O, Rudyk O, Robert Burgoyne J, Eaton P ( 2013 ) . The Blood Pressure-Lowering Action of the Reductant Hydrogen Sulfide Is Paradoxically Mediated by the Oxidative Activation of Protein Kinase G Iα . Free Radical Biology and Medicine . vol. 65 , S84 - S84 .

Burgoyne JR, Oviosu O, Eaton P ( 2013 ) . The PEG-switch assay: A fast semi-quantitative method to determine protein reversible cysteine oxidation . Journal of Pharmacological and Toxicological Methods vol. 68 , ( 3 ) 297 - 301 .

Rudyk O, Phinikaridou A, Prysyazhna O, Burgoyne JR, Botnar R, Eaton P ( 2013 ) . Protein kinase G oxidation contribute to hypotension and organ injury during sepsis . BMC Pharmacology and Toxicology vol. 14 , ( S1 ) Article P58 ,

Rudyk O, Phinikaridou A, Prysyazhna O, Burgoyne JR, Botnar RM, Eaton P ( 2013 ) . Protein kinase G oxidation is a major cause of injury during sepsis . Proceedings of the National Academy of Sciences vol. 110 , ( 24 ) 9909 - 9913 .

Burgoyne JR, Eaton P ( 2013 ) . Approaches for Monitoring PKG1α Oxidative Activation . 163 - 173 .

Burgoyne JR, Oka S-I, Ale-Agha N, Eaton P ( 2013 ) . Hydrogen Peroxide Sensing and Signaling by Protein Kinases in the Cardiovascular System . Antioxidants &amp; Redox Signaling vol. 18 , ( 9 ) 1042 - 1052 .

Burgoyne JR, Din HM, Eaton P, Shah AM ( 2013 ) . Response to Detailed Aspects of Redox Signaling in Cardiac Physiology and Pathology . Circulation Research vol. 112 , ( 1 )

Burgoyne JR, Eaton P ( 2013 ) . Detecting Disulfide-Bound Complexes and the Oxidative Regulation of Cyclic Nucleotide-Dependent Protein Kinases by H2O2 . 111 - 128 .

Fernandez-Caggiano M, Schroder E, Burgoyne J, Eaton P ( 2012 ) . Characterization of Redox Changes in Cardiac DJ-1 during Oxidant Stress . Free Radical Biology and Medicine . vol. 53 , S159 - S160 .

Charles R, Yin X, Mayr M, Eaton P ( 2012 ) . Detection and Identification of Cardiac Proteins Modified by the Dietary Flavanol Curcumin . Free Radical Biology and Medicine . vol. 53 , S157 - S158 .

Schroder E, Prysyazhna O, Charles R, Burgoyne J, Eaton P ( 2012 ) . Detection of Systemic Modification of Proteins in Mice by Sulforaphane after Oral Consumption . Free Radical Biology and Medicine . vol. 53 , S174 - S174 .

Prysyazhna O, Cuello F, Eaton P ( 2012 ) . Impaired Diastolic Relaxation in Cys42Ser PKGIalpha Mutant Mice . Free Radical Biology and Medicine . vol. 53 , S172 - S172 .

Robert Burgoyne J, Rudyk O, Eaton P ( 2012 ) . Protein Kinase a Regulatory RI Oxidation Mediates Angiogenesis . Free Radical Biology and Medicine . vol. 53 , S156 - S156 .

Robert Burgoyne J, Prysyazhna O, Rudyk O, Eaton P ( 2012 ) . cGMP Impedes Disulfide Activation of Protein Kinase G: Implications in Blood Pressure Regulation . Free Radical Biology and Medicine . vol. 53 , S156 - S156 .

Burgoyne JR, Prysyazhna O, Rudyk O, Eaton P ( 2012 ) . cGMP-Dependent Activation of Protein Kinase G Precludes Disulfide Activation . Hypertension vol. 60 , ( 5 ) 1301 - 1308 .

Burgoyne JR, Mongue-Din H, Eaton P, Shah AM ( 2012 ) . Redox Signaling in Cardiac Physiology and Pathology . Circulation Research vol. 111 , ( 8 ) 1091 - 1106 .

Burgoyne⁎ JR, Rudyk O, Eaton P ( 2012 ) . A potential role for PKA oxidation in growth factor mediated angiogenesis . Free Radical Biology and Medicine . vol. 53 , S129 - S129 .

Fernandez-Caggiano⁎ M, Schroder E, Eaton P ( 2012 ) . Dynamic and Complex Redox-Dependent Modifications of DJ-1 in Cardiac Cells and Tissue During Oxidative Stress . Free Radical Biology and Medicine . vol. 53 , S61 - S62 .

Burgoyne⁎ JR, Prysyazhna O, Eaton P ( 2012 ) . Dynamic interplay between classical and oxidative activation of PKG1α - implications for blood pressure control . Free Radical Biology and Medicine . vol. 53 , S129 - S130 .

Eaton⁎ P ( 2012 ) . In vivo dissection of redox-regulated protein kinase activation in the heart . Free Radical Biology and Medicine . vol. 53 , S21 - S21 .

Rudyk⁎ O, Prysyazhna O, Eaton P ( 2012 ) . Nitroglycerin fails to lower blood pressure in redox-dead Cys42Ser PKG1α knock-in mouse . Free Radical Biology and Medicine . vol. 53 , S138 - S138 .

Zhang M, Takimoto E, Lee D-I, Santos CXC, Nakamura T, Hsu S, Jiang A, Nagayama T et al. ( 2012 ) . Pathological Cardiac Hypertrophy Alters Intracellular Targeting of Phosphodiesterase Type 5 From Nitric Oxide Synthase-3 to Natriuretic Peptide Signaling . Circulation vol. 126 , ( 8 ) 942 - 951 .

Rudyk O, Prysyazhna O, Burgoyne JR, Eaton P ( 2012 ) . Nitroglycerin Fails to Lower Blood Pressure in Redox-Dead Cys42Ser PKG1α Knock-In Mouse . Circulation vol. 126 , ( 3 ) 287 - 295 .

Rudyk O, Prysyazhna O, Burgoyne JR, Eaton P ( 2012 ) . Loss of nitroglycerin-induced blood pressure lowering in redox-dead Cys42Ser PKG1α knock-in mouse . Nitric Oxide . vol. 27 , S13 - S14 .

Shao D, Oka S-I, Brady CD, Haendeler J, Eaton P, Sadoshima J ( 2012 ) . Redox modification of cell signaling in the cardiovascular system . Journal of Molecular and Cellular Cardiology vol. 52 , ( 3 ) 550 - 558 .

Prysyazhna O, Rudyk O, Eaton P ( 2012 ) . Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension . Nature Medicine vol. 18 , ( 2 ) 286 - 290 .

Prysyazhna O, Rudyk O, Eaton P ( 2012 ) . ATTENUATED EDHF-RESPONSE UNDERLIES HYPERTENSION IN REDOX-DEAD CYS42SER PKGIα KNOCK-IN MOUSE . JOURNAL OF VASCULAR RESEARCH . vol. 49 , 39 - 39 .

Wagner S, Neumann K, Daniel H, Dantz C, Moellenamp J, Eaton P, Maier LS ( 2012 ) . Redox-dead protein kinase A disturbs excitation-contraction coupling . EUROPEAN HEART JOURNAL . vol. 33 , 1044 - 1044 .

Prysyazhna O, Rudyk O, Eaton P ( 2011 ) . Cys42Ser Substitution in Murine Protein Kinase G1alpha Eliminates Oxidant Sensing To Cause Hypertension . Free Radical Biology and Medicine . vol. 51 , S49 - S49 .

Rudyk O, Prysyazhna O, Burgoyne J, Eaton P ( 2011 ) . Oxidation-Induced Activation of PKG 1alpha Contributes To Nitroglycerin-Induced Vasorelaxation . Free Radical Biology and Medicine . vol. 51 , S50 - S50 .

Burgoyne JR, Eaton P ( 2011 ) . Contemporary techniques for detecting and identifying proteins susceptible to reversible thiol oxidation . Biochemical Society Transactions vol. 39 , ( 5 ) 1260 - 1267 .

Akaike T, Vliet AVD, Eaton P ( 2011 ) . Frontiers in nitric oxide and redox signaling . Nitric Oxide vol. 25 , ( 2 ) 57 - 58 .

Prysyazhna O, Rudyk O, Eaton P ( 2011 ) . High blood pressure and lost EDHF response in redox dead Cys42Ser PKGIα knock-in mouse . BMC Pharmacology vol. 11 , ( S1 ) Article O22 ,

Burgoyne JR, Rudyk O, Mayr M, Eaton P ( 2011 ) . Nitrosative protein oxidation is modulated during early endotoxemia . Nitric Oxide vol. 25 , ( 2 ) 118 - 124 .

Ray R, Murdoch CE, Wang M, Santos CX, Zhang M, Alom-Ruiz S, Anilkumar N, Ouattara A et al. ( 2011 ) . Endothelial Nox4 NADPH Oxidase Enhances Vasodilatation and Reduces Blood Pressure In Vivo . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 31 , ( 6 ) 1368 - 1376 .

Charles RL, Burgoyne JR, Mayr M, Weldon SM, Hubner N, Dong H, Morisseau C, Hammock BD et al. ( 2011 ) . Redox Regulation of Soluble Epoxide Hydrolase by 15-Deoxy-Δ-Prostaglandin J\n ₂\n Controls Coronary Hypoxic Vasodilation . Circulation Research vol. 108 , ( 3 ) 324 - 334 .

Zhang M, Takimoto E, Lee DI, Santos CX, Hsu S, Bedja D, Yuan Y, Eaton P et al. ( 2011 ) . Altered PDE5 Targeting in Pathologic Hearts. Switching From NO-cGMP to ANP/BNP-cGMP . CIRCULATION . vol. 124 ,

Nakamura T, Shalkey V, Bedja D, Takimoto E, Eaton P, Kass DA ( 2011 ) . Cysteine Redox Dead in PKG-1α Suppresses Cardiac Pressure Overload-Induced Hypertrophy and Heart Failure . CIRCULATION . vol. 124 ,

Maller C, Schröder E, Eaton P ( 2011 ) . Glyceraldehyde 3-Phosphate Dehydrogenase is Unlikely to Mediate Hydrogen Peroxide Signaling: Studies with a Novel Anti-Dimedone Sulfenic Acid Antibody . Antioxidants &amp; Redox Signaling vol. 14 , ( 1 ) 49 - 60 .

Madhani M, Hall AR, Cuello F, Charles RL, Burgoyne JR, Fuller W, Hobbs AJ, Shattock MJ et al. ( 2010 ) . Phospholemman Ser69 phosphorylation contributes to sildenafil-induced cardioprotection against reperfusion injury . AM J PHYSIOL-HEART C vol. 299 , ( 3 ) H827 - H836 .

Burgoyne JR, Eaton P ( 2010 ) . Oxidant Sensing by Protein Kinases A and G Enables Integration of Cell Redox State with Phosphoregulation . Sensors vol. 10 , ( 4 ) 2731 - 2751 .

Burgoyne JR, Eaton P ( 2010 ) . A Rapid Approach for the Detection, Quantification, and Discovery of Novel Sulfenic Acid or S-Nitrosothiol Modified Proteins Using a Biotin-Switch Method . Methods in Enzymology , Elsevier

Oyama K, Ahtesham AK, Sawa T, Okamoto T, Fujii S, Eaton P, Akaike T ( 2010 ) . Activation mechanism of cGMP-dependent protein kinase by a nitrated derivative of cGMP . NITRIC OXIDE-BIOLOGY AND CHEMISTRY . vol. 22 , S57 - S57 .

Prysvazhna O, Eaton P ( 2010 ) . Deficit in hydrogen peroxide-induced vasodilation in thoracic aorta from redox-dead Cys42Ser PKGIα knock-in mouse . NITRIC OXIDE-BIOLOGY AND CHEMISTRY . vol. 22 , S50 - S51 .

Burgoyne JR, Eaton P ( 2009 ) . Transnitrosylating Nitric Oxide Species Directly Activate Type I Protein Kinase A, Providing a Novel Adenylate Cyclase-independent Cross-talk to β-Adrenergic-like Signaling . Journal of Biological Chemistry vol. 284 , ( 43 ) 29260 - 29268 .

Schröder E, Eaton P ( 2009 ) . Hydrogen Peroxide and Cysteine Protein Signaling Pathways . Wiley

Burgoyne JR, Eaton P ( 2009 ) . Beating the silent killer: A new way to relax . Biologist vol. 56 , ( 1 ) 40 - 45 .

Eaton P, Clements‐Jewery H ( 2009 ) . Peroxynitrite: <i>in vivo</i> cardioprotectant or arrhythmogen? . British Journal of Pharmacology vol. 155 , ( 7 ) 972 - 973 .

Charles RL, Burgoyne J, Mayr M, Landar A, Eaton P ( 2009 ) . 15-deoxy-Δ 12, 14-prostaglandin J₂ Adducts to Soluble Epoxide Hydrolase at Cys521 Resulting in its Inhibition which Couples to Coronary Vasodilation . FREE RADICAL BIOLOGY AND MEDICINE . vol. 47 , S56 - S56 .

Burgoyne JR, Eaton P ( 2009 ) . Novel cAMP-Independent Mechanism for Beta-Adrenergic like Signalling Through Direct Activation of Type 1 PKA by S-Nitrosylation . FREE RADICAL BIOLOGY AND MEDICINE . vol. 47 , S54 - S55 .

Eaton P ( 2009 ) . Redox control of protein kinase G couples to vasoregulation . FREE RADICAL RESEARCH . vol. 43 , 31 - 31 .

Schröder E, Brennan JP, Eaton P ( 2008 ) . Cardiac peroxiredoxins undergo complex modifications during cardiac oxidant stress . American Journal of Physiology-Heart and Circulatory Physiology vol. 295 , ( 1 ) H425 - H433 .

Charles RL, Eaton P ( 2008 ) . Redox signalling in cardiovascular disease . PROTEOMICS – Clinical Applications vol. 2 , ( 6 ) 823 - 836 .

SCHRODER E, EATON P ( 2008 ) . Hydrogen peroxide as an endogenous mediator and exogenous tool in cardiovascular research: issues and considerations . Current Opinion in Pharmacology vol. 8 , ( 2 ) 153 - 159 .

Bell JR, Kennington E, Fuller W, Dighe K, Donoghue P, Clark JE, Jia L-G, Tucker AL et al. ( 2008 ) . Characterization of the phospholemman knockout mouse heart: depressed left ventricular function with increased Na-K-ATPase activity . American Journal of Physiology-Heart and Circulatory Physiology vol. 294 , ( 2 ) H613 - H621 .

Eaton P ( 2008 ) . O3. Redox regulation of protein kinases A and G in the cardiovascular system . Nitric Oxide . vol. 19 , 20 - 20 .

Eaton P ( 2008 ) . REDOX REGULATION OF PROTEIN KINASE G . FREE RADICAL BIOLOGY AND MEDICINE . vol. 45 , S10 - S10 .

Burgoyne JR, Mayr M, Eaton P ( 2008 ) . S-Nitrosylation in the Rat Heart: a Novel Mechanism for the Activation of PKG1a and Type I PKA . FREE RADICAL BIOLOGY AND MEDICINE . vol. 45 , S111 - S111 .

Bell JR, Eaton P, Shattock MJ ( 2007 ) . ROLE OF p38‐MITOGEN‐ACTIVATED PROTEIN KINASE IN ISCHAEMIC PRECONDITIONING IN RAT HEART . Clinical and Experimental Pharmacology and Physiology vol. 35 , ( 2 ) 126 - 134 .

Burgoyne JR, Madhani M, Cuello F, Charles RL, Brennan JP, Schröder E, Browning DD, Eaton P ( 2007 ) . Cysteine Redox Sensor in PKGIa Enables Oxidant-Induced Activation . Science vol. 317 , ( 5843 ) 1393 - 1397 .

Charles RL, Schroder E, May G, Free P, Gaffney PRJ, Wait R, Begum S, Heads RJ et al. ( 2007 ) . Protein sulfenation as a redox sensor - Proteomics studies using a novel biotinylated dimedone analogue . MOL CELL PROTEOMICS vol. 6 , ( 9 ) 1473 - 1484 .

Burgoyne JR, Madhani M, Cuello F, Charles RL, Brennan JP, Schroeder E, Eaton P ( 2007 ) . H2O2 operates as an endothelium-derived hyperpolarizing factor by directly activating protein kinase G (PKG) Iα independently of cGMP via disulfide formation . CIRCULATION . vol. 116 , 8 - 8 .

Brennan JP, Bardswell SC, Burgoyne JR, Fuller W, Schroder E, Wait R, Begum S, Kentish JC et al. ( 2006 ) . Direct activation of type I protein kinase a (PKA) by oxidants independently of cAMP is mediated by RI subunit interprotein disulphide bond formation . CIRCULATION . vol. 114 , 1 - 2 .

Brennan JP, Bardswell SC, Burgoyne JR, Fuller W, Schroder E, Wait R, Begum S, Kentish JC et al. ( 2006 ) . Oxidant-induced activation of type I protein kinase a is mediated by RI subunit interprotein disulfide bond formation . J BIOL CHEM vol. 281 , ( 31 ) 21827 - 21836 .

Brennan JP, Eaton P ( 2006 ) . Oxidized Proteins in Cardiac Ischemia and Reperfusion . Wiley

Eaton P ( 2006 ) . Protein thiol oxidation in health and disease: Techniques for measuring disulfides and related modifications in complex protein mixtures . Free Radical Biology and Medicine vol. 40 , ( 11 ) 1889 - 1899 .

Brennan JP, Miller JIA, Fuller W, Wait R, Begum S, Dunn MJ, Eaton P ( 2006 ) . The utility of N,N-biotinyl glutathione disulfide in the study of protein S-glutathiolation . MOL CELL PROTEOMICS vol. 5 , ( 2 ) 215 - 225 .

EATON P, SHATTOCK MJ ( 2002 ) . Purification of Proteins Susceptible to Oxidation at Cysteine Residues: Identification of Malate Dehydrogenase as a Target for S‐Glutathiolation . Annals of the New York Academy of Sciences . vol. 973 , 529 - 532 .

Schröder E, Brennan JP, Eaton P ( 2006 ) . Modification of cardiac peroxiredoxin in response to hydrogen peroxide . HEART . vol. 92 ,

Burgoyne JR, Brennan JP, Eaton P ( 2006 ) . Studies assessing protein S-nitrosylation in the rat heart . HEART . vol. 92 ,

Eaton P, Bell RM, Cave AC, Shattock MJ ( 2005 ) . Ischemic Preconditioning: A Potential Role for Protein<i>S</i>-Thiolation? . Antioxidants &amp; Redox Signaling vol. 7 , ( 7-8 ) 882 - 888 .

Eaton P, Shattock MJ ( 2005 ) . Protein <i>S</i>-Thiolation: Emphasis on Cell Signaling and Gene Expression . Antioxidants &amp; Redox Signaling vol. 7 , ( 7-8 ) 839 - 840 .

SILVERMAN B, FULLER W, EATON P, DENG J, MOORMAN J, CHEUNG J, JAMES A, SHATTOCK M ( 2005 ) . Serine 68 phosphorylation of phospholemman: acute isoform-specific activation of cardiac Na/K ATPase . Cardiovascular Research vol. 65 , ( 1 ) 93 - 103 .

Saurin AT, Neubert H, Brennan JP, Eaton P ( 2004 ) . Widespread sulfenic acid formation in tissues in response to hydrogen peroxide . Proceedings of the National Academy of Sciences vol. 101 , ( 52 ) 17982 - 17987 .

Brennan JP, Wait R, Begum S, Bell JR, Dunn MJ, Eaton P ( 2004 ) . Detection and mapping of widespread intermolecular protein disulfide formation during cardiac oxidative stress using proteomics with diagonal electrophoresis . J BIOL CHEM vol. 279 , ( 40 ) 41352 - 41360 .

Fuller W, Eaton P, Bell JR, Shattock MJ ( 2003 ) . Ischemia‐induced phosphorylation of phospholemman directly activates rat cardiac Na/K ATPase . The FASEB Journal vol. 18 , ( 1 ) 197 - 199 .

THOMAS JD, EATON P ( 2003 ) . Accumulation of free amino acids and humic substances in a freshwater modular system and their ecological significance . Freshwater Biology vol. 35 , ( 2 ) 323 - 338 .

Eaton P, Jones ME, McGregor E, Dunn MJ, Leeds N, Byers HL, Leung KY, Ward MA et al. ( 2003 ) . Reversible cysteine-targeted oxidation of proteins during renal oxidative stress . JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY . vol. 14 , S290 - S296 .

Fuller W ( 2003 ) . Cardiac ischemia causes inhibition of the Na/K ATPase by a labile cytosolic compound whose production is linked to oxidant stress . Cardiovascular Research vol. 57 , ( 4 ) 1044 - 1051 .

Eaton P, Wright N, Hearse DJ, Shattock MJ ( 2002 ) . Glyceraldehyde Phosphate Dehydrogenase Oxidation During Cardiac Ischemia and Reperfusion . Journal of Molecular and Cellular Cardiology vol. 34 , ( 11 ) 1549 - 1560 .

Eaton P, Fuller W, Shattock MJ ( 2002 ) . S-Thiolation of HSP27 Regulates Its Multimeric Aggregate Size Independently of Phosphorylation . Journal of Biological Chemistry vol. 277 , ( 24 ) 21189 - 21196 .

Eaton P, Byers HL, Leeds N, Ward MA, Shattock MJ ( 2002 ) . Detection, Quantitation, Purification, and Identification of Cardiac Proteins S-Thiolated during Ischemia and Reperfusion . Journal of Biological Chemistry vol. 277 , ( 12 ) 9806 - 9811 .

Eaton P, Fuller W, Bell JR, Shattock MJ ( 2001 ) . α B Crystallin Translocation and Phosphorylation: Signal Transduction Pathways and Preconditioning in the Isolated Rat Heart . Journal of Molecular and Cellular Cardiology vol. 33 , ( 9 ) 1659 - 1671 .

Eaton P ( 2001 ) . Lipid hydroperoxide modification of proteins during myocardial ischaemia . Cardiovascular Research vol. 51 , ( 2 ) 294 - 303 .

Fuller W, Eaton P, Medina RA, Bell J, Shattock MJ ( 2001 ) . Differential centrifugation separates cardiac sarcolemmal and endosomal membranes from Langendorff-perfused rat hearts . ANAL BIOCHEM vol. 293 , ( 2 ) 216 - 223 .

Eaton P, Awad WI, Miller JIA, Hearse DJ, Shattock MJ ( 2000 ) . Ischemic Preconditioning: a Potential Role for Constitutive Low Molecular Weight Stress Protein Translocation and Phosphorylation? . Journal of Molecular and Cellular Cardiology vol. 32 , ( 6 ) 961 - 971 .

Eaton P, Thomas JD ( 1999 ) . The accumulation and metabolism of amino acids by Biomphalaria glabrata, a freshwater pulmonate snail . Comparative Biochemistry and Physiology Part A: Molecular &amp; Integrative Physiology vol. 122 , ( 4 ) 421 - 428 .

Eaton P, Li J-M, Hearse DJ, Shattock MJ ( 1999 ) . Formation of 4-hydroxy-2-nonenal-modified proteins in ischemic rat heart . American Journal of Physiology-Heart and Circulatory Physiology vol. 276 , ( 3 ) H935 - H943 .

Thomas JD, Eaton P ( 1998 ) . The Origins, Fate, and Ecological Significance of Free Amino Compounds Released by Freshwater Pulmonate Snails . Comparative Biochemistry and Physiology Part A: Molecular &amp; Integrative Physiology . vol. 119 , 341 - 349 .

Thomas JD, Eaton P ( 1996 ) . The accumulation of amino-acids and humic substances in media conditioned by axenic and non-axenic duckweed (Lemna minor L.) and their possible ecological significance . Hydrobiologia vol. 333 , ( 2 ) 121 - 128 .

Thomas JD, Eaton P ( 1996 ) . The spatio-temporal patterns and ecological significance of free amino acids and humic substances in contrasting oligotrophic and eutrophic freshwater ecosystems . Hydrobiologia vol. 332 , ( 3 ) 183 - 211 .

Thomas JD, Eaton P ( 1993 ) . Amino acid medleys of snail origin as possible sources of information for conspecifics, schistosome miracidia and predators . Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology vol. 106 , ( 3 ) 781 - 796 .