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  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: MS Beatrice Malacrida

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Flanagan S, Stanley R, Tan SY, Malacrida B, Petit N, O’Reilly D, Naidoo J, Browne S et al. ( 2026 ) . Abstract 4735: Designing a novel 3D co-culture model incorporating patient T-cells to study lipid metabolism as a metabolic vulnerability in KRAS driven non-small cell lung cancer . Cancer Research vol. 86 , ( 7_Supplement ) 4735 - 4735 .
Malacrida B, Elorbany S, Laforêts F, Karim F, Bryan-Ravenscroft RC, Sideris M, Joy JD, Kotantaki P et al. ( 2026 ) . 3D pentaculture model unveils malignant cell-driven macrophage polarization in high-grade serous ovarian cancer . Nature Communications vol. 17 , ( 1 )
Laforêts F, Kotantaki P, Elorbany S, Hartlebury J, Joy JD, Malacrida B, Bryan-Ravenscroft RC, Berlato C et al. ( 2026 ) . Matrix structure and microenvironment dynamics correlate with chemotherapy response in ovarian cancer . iScience vol. 29 , ( 3 )
Kenny HA, Ip CKM, Kelliher L, Samantaray T, Kordylewicz K, Hoffmann R, Rauch S, Malacrida B et al. ( 2025 ) . Navitoclax, a Bcl-2/xL inhibitor, and YM155, a survivin inhibitor, in combination with carboplatin, effectively inhibit ovarian cancer tumor growth . Molecular Cancer Therapeutics vol. 24 , ( 8 ) 1252 - 1264 .
Samantaray T, Kenny H, Kelliher L, Lengyel ER, Ip CKM, Kordylewicz K, Hoffmann R, Rauch S et al. ( 2025 ) . Abstract 1677: Navitoclax, a Bcl-2/xL inhibitor, and YM155, a survivin inhibitor, in combination with carboplatin effectively inhibit ovarian cancer tumor growth . Cancer Research vol. 85 , ( 8_Supplement_1 ) 1677 - 1677 .
Flanagan S, Stanley R, Malacrida B, O’Reilly D, Naidoo J, Murray P, Dowling CM ( 2025 ) . Abstract 4160: Lipid metabolism is a metabolic vulnerability in LKB1 mutant, KRAS driven non-small cell lung cancer . Cancer Research vol. 85 , ( 8_Supplement_1 ) 4160 - 4160 .
Joy JD, Malacrida B, Laforêts F, Kotantaki P, Maniati E, Manchanda R, Annibaldi A, Hopkins S et al. ( 2024 ) . Human 3D Ovarian Cancer Models Reveal Malignant Cell–Intrinsic and –Extrinsic Factors That Influence CAR T-cell Activity . Cancer Research vol. 84 , ( 15 ) 2432 - 2449 .
Kenny HA, Ip C, kordylewicz K, Hoffmann R, Rauch S, Malacrida B, Balkwill FR, Battistini C et al. ( 2024 ) . Abstract A016: Organotypic high-throughput screening identifies the combinatorial treatment of navitoclax and YM155 that target chemoresistant ovarian cancer cells . Cancer Research vol. 84 , ( 5_Supplement_2 ) a016 - a016 .
Battistini C, Kenny HA, Nieddu V, Melocchi V, Decio A, Malacrida B, Gatto A, Bianchi F et al. ( 2024 ) . Abstract B068: FOXM1 mediates the crosstalk between tumor microenvironment and ovarian cancer stem cells as revealed by patient-derived organotypic models . Cancer Research vol. 84 , ( 5_Supplement_2 ) b068 - b068 .
Joy JD, Malacrida B, Laforets F, Kotantaki P, Maniati E, Manchanda R, Hopkins S, Garrobo-Calleja I et al. ( 2024 ) . Abstract B079: Human 3D ovarian cancer models reveal malignant cell intrinsic and extrinsic factors that influence CAR-T cell activity . Cancer Research vol. 84 , ( 5_Supplement_2 ) b079 - b079 .
Malacrida B, Elorbany S, Maniati E, Bryan-Ravenscroft R, Skingsley SLP, Laforets F, Manchanda R, Balkwill FR ( 2024 ) . Abstract PR-009: Reconstructing the metastatic tumor microenvironment of high grade serous ovarian cancer using human multicellular in vitro models . Cancer Research . vol. 84 ,
Elorbany S, Malacrida B ( 2023 ) . Interferon epsilon and ovarian cancer . Trends in Cancer vol. 9 , ( 12 ) 985 - 986 .
Malacrida B, Elorbany S, Maniati E, Laforets F, Manchanda R, Balkwill FR ( 2023 ) . Abstract 4551: Reconstructing the metastatic tumor microenvironment of high grade serous ovarian cancer: understanding the contribution of malignant cells . Cancer Research . vol. 83 , 4551 - 4551 .
Joy JD, Malacrida B, Laforêts F, Kotantaki P, Maniati E, Hopkins S, Garrobo-Calleja I, Gautrot J et al. ( 2023 ) . Abstract 4576: 3D in vitro models uncover malignant cell intrinsic and extrinsic mechanisms of CAR-T cell resistance in high grade serous ovarian cancer . Cancer Research vol. 83 , ( 7_Supplement ) 4576 - 4576 .
Laforets F, Kotantaki P, Malacrida B, Elorbany S, Manchanda R, Donnadieu E, Balkwill F ( 2023 ) . Abstract 5913: Semi-supervised analysis of myeloid and T cell behavior in ex vivo ovarian tumor slices reveals changes in cell motility after treatments . Cancer Research . vol. 83 , 5913 - 5913 .
Kotantaki P, Laforêts F, Maniati E, Berlato C, Malliouri A, Devlin MJ, Malacrida B, Elorbany S et al. ( 2023 ) . Abstract 5957: Chemotherapy-induced extracellular matrix remodeling in HGSOC . Cancer Research . vol. 83 , 5957 - 5957 .
Laforêts F, Kotantaki P, Malacrida B, Elorbany S, Manchanda R, Donnadieu E, Balkwill F ( 2023 ) . Semi-supervised analysis of myeloid and T cell behavior in ex vivo ovarian tumor slices reveals changes in cell motility after treatments . iScience vol. 26 , ( 4 )
Olivera I, Sanz-Pamplona R, Bolaños E, Rodriguez I, Etxeberria I, Cirella A, Egea J, Garasa S et al. ( 2022 ) . A Therapeutically Actionable Protumoral Axis of Cytokines Involving IL-8, TNFα, and IL-1β . Cancer Discovery vol. 12 , ( 9 ) 2140 - 2157 .
Joy JD, Malacrida B, Laforêts F, Kotantaki P, Maniati E, Hopkins S, Calleja I, Brett S et al. ( 2022 ) . Abstract 693: TGFβ-mediated targeting of the extracellular matrix enhances the migration and cytotoxicity of CAR-T cells in 3D models of ovarian cancer . Cancer Research vol. 82 , ( 12_Supplement ) 693 - 693 .
Malacrida B, Balkwill FR ( 2022 ) . Building in vitro 3D human multicellular models of high-grade serous ovarian cancer . STAR Protocols vol. 3 , ( 1 )
Laforêts F, Kotantaki P, Malacrida B, Elorbany S, Manchanda R, Donnadieu E, Balkwill F ( 2022 ) . Semi-Supervised Analysis of Myeloid and T Cell Behaviour in ex vivo Ovarian Tumour Slices Reveals Changes in Cell Motility After Treatments .
Malacrida B, Delaine-Smith R, Nichols S, Maniati E, Jones RL, Knight MM, Pearce OM, Balkwill FR ( 2021 ) . Abstract 2642: Using 3-Dimensional in vitro models to unravel the complexity of the metastatic microenvironment in high-grade serous ovarian cancer . Cancer Research . vol. 81 , 2642 - 2642 .
Malacrida B, Nichols S, Maniati E, Jones R, Delanie-Smith R, Roozitalab R, Tyler EJ, Thomas M et al. ( 2021 ) . A human multi-cellular model shows how platelets drive production of diseased extracellular matrix and tissue invasion . iScience vol. 24 , ( 6 )
Delaine-Smith RM, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones RR, Lecker LSM, Pearce OMT et al. ( 2021 ) . Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer . iScience vol. 24 , ( 6 )
Delaine-Smith RM, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones RR, Lecker L, Pearce OMT et al. ( 2021 ) . Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer .
Mahdi AF, Malacrida B, Nolan J, McCumiskey ME, Merrigan AB, Lal A, Lowery AJ ( 2020 ) . Expression of Annexin A2 Promotes Cancer Progression in Estrogen Receptor Negative Breast Cancers . Cells vol. 9 , ( 7 )
Mahdi AF, Malacrida B, Nolan J, McGourty K, Lowery AJ ( 2019 ) . Abstract 2027: Understanding the role and regulation of newly synthesized Annexin A2 in the progression of breast cancer . Conference: Tumor Biology2027 - 2027 .
Flygaard RK, Malacrida B, Kiely P, Jenner LB ( 2019 ) . Purification and characterization of native human elongation factor 2 . Protein Expression and Purification vol. 158 , 15 - 19 .
Collins CM, Malacrida B, Burke C, Kiely PA, Dunleavy EM ( 2018 ) . ATP synthase F1 subunits recruited to centromeres by CENP-A are required for male meiosis . Nature Communications vol. 9 , ( 1 )
Day JP, Whiteley E, Freeley M, Long A, Malacrida B, Kiely P, Baillie GS ( 2018 ) . RAB40C regulates RACK1 stability via the ubiquitinproteasome system . Future Science OA vol. 4 , ( 7 )
Malacrida B, Dowling CM, Flygaard RK, Kiely M, Coffey JC, Jenner LB, Kiely PA ( 2018 ) . Abstract 1914: Elongation factor 2: A novel target for cancer progression . Cancer Research . vol. 78 , 1914 - 1914 .
Mahdi AF, Malacrida B, McGourty K, Lowery AJ, Kiely PA ( 2018 ) . Abstract 2100: Using in vitro models to identify newly synthesised proteins involved in the progression of breast cancer . Cancer Research . vol. 78 , 2100 - 2100 .
Mahdi AF, Malacrida B, Lowery AJ, Kiely PA ( 2018 ) . AB071. 60. Using in vitro models to identify and target proteins involved in the progression of breast cancer . Mesentery and Peritoneum vol. 2 , ( 2 ) ab071 - ab071 .
Malacrida B, Flygaard RK, Dowling CM, Coffey JC, Jenner LB, Kiely PA ( 2017 ) . Abstract 4485: Identification and characterization of novel RACK1 binding partners that may modulate the elongation phase of protein synthesis . Cancer Research . vol. 77 , 4485 - 4485 .
Hayes S, Malacrida B, Kiely M, Kiely PA ( 2016 ) . Studying protein-protein interactions: progress, pitfalls and solutions . Biochemical Society Transactions vol. 44 , ( 4 ) 994 - 1004 .
Pinto A, Malacrida B, Oieni J, Serafini MM, Davin A, Galbiati V, Corsini E, Racchi M ( 2015 ) . DHEA modulates the effect of cortisol on RACK1 expression via interference with the splicing of the glucocorticoid receptor . British Journal of Pharmacology vol. 172 , ( 11 ) 2918 - 2927 .
Laforêts F, Kotantaki P, Elorbany S, Hartlebury J, Joy JD, Malacrida B, Bryan-Ravenscroft RC, Berlato C et al. . Matrix structure and microenvironment dynamics correlate with chemotherapy response in ovarian cancer .
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