Publications: PROF Kamil Kranc

Sarni D, Neary G, Carroll PL, Vink CS, Billard CV, Isobe T, Weng X, Portman JR et al. ( 2026 ) . A progeria syndrome links DNA hypermethylation to age-related pathology . Nature Genetics vol. 58 , ( 7 ) 1632 - 1642 .

Barcelo J, Teigen Y, Martin JAJ, George S, Das D, Sewell J, Perdrix-Rosell A, Bewicke-Copley F et al. ( 2026 ) . Pan-cancer analysis reveals Rho kinase addiction as a vulnerability of de-differentiated cancer cells . iScience vol. 29 , ( 6 )

To P, Dragunaite B, Casado P, Hoang Q-A, Alard E, Harrison-Oakes L, Velleca A, Woodley K et al. ( 2025 ) . Investigating ribosome biogenesis in AML identifies MYB-binding protein 1A (MYBBP1A) as an essential regulator of leukemia cells . Blood vol. 146 , ( Supplement 1 )

Ragusa D, Suen CW, Cortes GT, Pastorino F, Johns A, Cicirò Y, Dijkhuis L, van den Brink S et al. ( 2025 ) . Dissecting infant leukemia developmental origins with a hemogenic gastruloid model . vol. 14 ,

Abdelfattah A, Habib A, Thomas L-A, Menendez-Gonzalez JB, Almotiri A, Alqahtani H, Lawson H, Taha S et al. ( 2025 ) . Impaired DNA damage responses and inflammatory signaling underpin hematopoietic stem cell defects in Gata2 haploinsufficiency . Stem Cell Reports vol. 20 , ( 8 )

Dembitz V, Lawson H, Burt R, Natani S, Philippe C, James SC, Atkinson S, Durko J et al. ( 2024 ) . Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation . Leukemia vol. 38 , ( 11 ) 2395 - 2409 .

Mapperley C, Kranc KR ( 2024 ) . HOXA9 and β-catenin safeguard HSC integrity . Blood vol. 143 , ( 16 ) 1554 - 1556 .

Lawson H, Holt-Martyn JP, Dembitz V, Kabayama Y, Wang LM, Bellani A, Atwal S, Saffoon N et al. ( 2024 ) . The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia . Nature Cancer vol. 5 , ( 6 ) 916 - 937 .

Dembitz V, Durko J, Campos J, James SC, Lawson H, Kranc KR, Gallipoli P ( 2024 ) . Immunodeficient NBSGW mouse strain allows chemotherapy modeling in AML patient‐derived xenografts . HemaSphere vol. 8 , ( 1 )

Kucinski I, Campos J, Barile M, Severi F, Bohin N, Moreira PN, Allen L, Lawson H et al. ( 2024 ) . A time- and single-cell-resolved model of murine bone marrow hematopoiesis . Cell Stem Cell vol. 31 , ( 2 ) 244 - 259.e10 .

Gorur V, Kranc KR, Ganuza M, Telfer P ( 2023 ) . Haematopoietic stem cell health in sickle cell disease and its implications for stem cell therapies and secondary haematological disorders . Blood Reviews vol. 63 ,

Woodley K, Dillingh LS, Giotopoulos G, Madrigal P, Rattigan KM, Philippe C, Dembitz V, Magee AMS et al. ( 2023 ) . Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death . Nature Communications vol. 14 , ( 1 )

Fyfe C, Fiorentino G, Steinbaugh MJ, Campos J, Lawson H, Durko J, O'Carroll D, Kranc K et al. ( 2023 ) . Abstract 447: Genetic and pharmacological inhibition of TUT4 and TUT7 sensitizes AML cells to BCL-2 inhibition . Cancer Research vol. 83 , ( 7_Supplement ) 447 - 447 .

Kranc KR, Bamforth SD, Bragança J, van Lohuizen M ( 2023 ) . Transcriptional Coactivator Cited2 Induces Bmi1 and Mel18 and Controls Fibroblast Proliferation via Ink4a/ARF . Molecular and Cellular Biology vol. 23 , ( 21 ) 7658 - 7666 .

Secchi M, Gonzalez-Anton S, Tromans-Coia C, Cimini B, O'Caroll D, Kranc K, Celso CL, Luis TC ( 2023 ) . 3173 – INTRAVITAL MICROSCOPY OF HIGHLY PURE HAEMATOPOIETIC STEM CELLS USING A NOVEL TRANSGENIC REPORTER STRATEGY UNCOVERS UNEXPECTED INTERACTION DYNAMICS WITHIN THE STEM CELL NICHE . Experimental Hematology vol. 124 ,

Secchi M, Gonzalez-Anton S, Tromans-Coia C, Cimini B, O'Caroll D, Kranc K, Lo Celso C, Luis TC ( 2023 ) . INTRAVITAL MICROSCOPY OF HIGHLY PURE HAEMATOPOIETIC STEM CELLS USING A NOVEL TRANSGENIC REPORTER STRATEGY UNCOVERS UNEXPECTED INTERACTION DYNAMICS WITHIN THE STEM CELL NICHE . EXPERIMENTAL HEMATOLOGY . vol. 124 , S136 - S136 .

Fyfe C, Fiorentino G, Steinbaugh M, Campos J, Lawson H, Durko J, O'Carroll D, Kranc K et al. ( 2022 ) . Genetic and Pharmacological Inhibition of TUT4/TUT7 Sensitizes AML Cells to BCL-2 Inhibition . Blood vol. 140 , ( Supplement 1 )

Ragusa D, Suen C-W, Torregrosa G, Dijkhuis L, Byrne C, Balayo T, Tavosanis A, Durko J et al. ( 2022 ) . Haemogenic Gastruloids Recapitulate Developmental Haematopoiesis and Provide an Ontogeny-Relevant Context to Dissect the Origins of Infant Leukemia . Blood vol. 140 , ( Supplement 1 ) 1684 - 1685 .

Dembitz V, Lawson H, Philippe C, Burt RJ, James S, Magee ASM, Woodley K, Durko J et al. ( 2022 ) . Inhibition of Stearoyl-CoA Desaturase Has Anti-Leukemic Properties in Acute Myeloid Leukemia . Blood vol. 140 , ( Supplement 1 ) 3058 - 3060 .

Lawson H, Holt-Martyn J, Dembitz V, Durko J, Kabayama Y, Wang L, Van De Lagemaat L, Dubusse L et al. ( 2022 ) . Targeting HIF-Hydroxylases Compromises Disease Initiation and Propagation, and Synergises with Current Therapies to Eliminate Cancer Stem Cells in AML . Blood vol. 140 , ( Supplement 1 ) 8731 - 8732 .

Edwards-Hicks J, Su H, Mangolini M, Yoneten KK, Wills J, Rodriguez-Blanco G, Young C, Cho K et al. ( 2022 ) . MYC sensitises cells to apoptosis by driving energetic demand . Nature Communications vol. 13 , ( 1 )

Mirchandani AS, Jenkins SJ, Bain CC, Sanchez-Garcia MA, Lawson H, Coelho P, Murphy F, Griffith DM et al. ( 2022 ) . Author Correction: Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation . Nature Immunology vol. 23 , ( 9 ) 1394 - 1394 .

Young C, Russell JR, Van De Lagemaat LN, Lawson H, Mapperley C, Kranc KR, Christophorou MA ( 2022 ) . Intrinsic function of the peptidylarginine deiminase PADI4 is dispensable for normal haematopoiesis . Biology Open vol. 11 , ( 6 )

Mirchandani AS, Jenkins SJ, Bain CC, Sanchez-Garcia MA, Lawson H, Coelho P, Murphy F, Griffith DM et al. ( 2022 ) . Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation . Nature Immunology vol. 23 , ( 6 ) 927 - 939 .

Sommerkamp P, Brown JA, Haltalli MLR, Mercier FE, Vu LP ( 2022 ) . m6A RNA modifications: Key regulators of normal and malignant hematopoiesis . Experimental Hematology vol. 111 , 25 - 31 .

Turner DJ, Saveliev A, Salerno F, Matheson LS, Screen M, Lawson H, Wotherspoon D, Kranc KR et al. ( 2022 ) . A functional screen of RNA binding proteins identifies genes that promote or limit the accumulation of CD138+ plasma cells . vol. 11 ,

Mapperley C, Lawson H, Kabayama Y, Georges E, Azar A, Van der Lagemaat L, Paris J, Morgan M et al. ( 2022 ) . 3009 – THERAPEUTIC TARGETING OF RNA DEGRADATION PATHWAYS- NEW AVENUES FOR INTERVENTION IN ACUTE MYELOID LEUKAEMIA . Experimental Hematology vol. 111 ,

Mapperley C, Lawson H, Kabayama Y, Azar A, Paris J, Morgan M, Vernimmen D ( 2022 ) . THERAPEUTIC TARGETING OF RNA DEGRADATION PATHWAYS- NEW AVENUES FOR INTERVENTION IN ACUTE MYELOID LEUKAEMIA . EXPERIMENTAL HEMATOLOGY . vol. 111 , S49 - S49 .

Lawson H, van de Lagemaat LN, Barile M, Tavosanis A, Durko J, Villacreces A, Bellani A, Mapperley C et al. ( 2021 ) . CITED2 coordinates key hematopoietic regulatory pathways to maintain the HSC pool in both steady-state hematopoiesis and transplantation . Stem Cell Reports vol. 16 , ( 11 ) 2784 - 2797 .

Adam J, Finch A, Sepulveda C, Ducker M, Torroba MB, Krell D, Szele F, Ratcliffe P et al. ( 2021 ) . Elevated 2HG does not cause features of tumorigenesis . Neuro-Oncology . vol. 23 , iv1 - iv1 .

Neary G, Vink C, Heyn P, Campos J, Paris J, Young C, Kranc K, Dzierzak E et al. ( 2021 ) . 3106 – A GAIN OF FUNCTION MUTATION IN DNMT3A IMPAIRS HAEMATOPOIESIS . Experimental Hematology vol. 100 ,

Codino A, Turowski T, van de Lagemaat LN, Ivanova I, Tavosanis A, Much C, Auchynnikava T, Vasiliauskaitė L et al. ( 2021 ) . NANOS2 is a sequence-specific mRNA-binding protein that promotes transcript degradation in spermatogonial stem cells . iScience vol. 24 , ( 7 )

Kranc KR ( 2021 ) . The essential reading list for AML: the m6A transcripts . Blood vol. 138 , ( 1 ) 6 - 7 .

Lawson H, Sepulveda C, van de Lagemaat LN, Durko J, Barile M, Tavosanis A, Georges E, Shmakova A et al. ( 2021 ) . JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells . Blood Advances vol. 5 , ( 3 ) 889 - 899 .

Mapperley C, van de Lagemaat LN, Lawson H, Tavosanis A, Paris J, Campos J, Wotherspoon D, Durko J et al. ( 2020 ) . The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function . Journal of Experimental Medicine vol. 218 , ( 3 )

Luis TC, Lawson H, Kranc KR ( 2020 ) . Divide and Rule: Mitochondrial Fission Regulates Quiescence in Hematopoietic Stem Cells . Cell Stem Cell vol. 26 , ( 3 ) 299 - 301 .

Baumeister J, Chatain N, Hubrich A, Maié T, Costa IG, Han L, Küstermann C, Sontag S et al. ( 2019 ) . Hypoxia-inducible factor 1 (HIF-1) is a new therapeutic target in JAK2V617F-positive myeloproliferative neoplasms . Leukemia vol. 34 , ( 4 ) 1062 - 1074 .

Menendez-Gonzalez JB, Vukovic M, Abdelfattah A, Saleh L, Almotiri A, Thomas L-A, Azevedo A, Menezes AC et al. ( 2019 ) . Gata2 as a Crucial Regulator of Stem Cells in Adult Hematopoiesis and Acute Myeloid Leukemia . Stem Cell Reports vol. 13 , ( 2 ) 291 - 306 .

Yamamoto A, Hester J, Macklin PS, Kawai K, Uchiyama M, Biggs D, Bishop T, Bull K et al. ( 2019 ) . Systemic silencing of PHD2 causes reversible immune regulatory dysfunction . Journal of Clinical Investigation vol. 129 , ( 9 ) 3640 - 3656 .

Mogilenko DA, Haas JT, L’homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J et al. ( 2019 ) . Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR . Cell vol. 178 , ( 1 )

Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Becquart C, Wartelle J, Pineau L et al. ( 2019 ) . Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR . Cell vol. 177 , ( 5 ) 1201 - 1216.e19 .

Paris J, Morgan M, Campos J, Spencer GJ, Shmakova A, Ivanova I, Mapperley C, Lawson H et al. ( 2019 ) . Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia . Cell Stem Cell vol. 25 , ( 1 ) 137 - 148.e6 .

Baumeister J, Chatain N, Hubrich A, Küstermann C, Sontag S, Seré K, Zenke M, Brümmendorf TH et al. ( 2018 ) . Implication of Hypoxia-Inducible Factor-1 (HIF-1) As a New Therapeutic Target in JAK2V617F Positive Myeloproliferative Neoplasms (MPN) . Blood . vol. 132 ,

van de Lagemaat LN, Flenley M, Lynch MD, Garrick D, Tomlinson SR ( 2018 ) . CpG binding protein (CFP1) occupies open chromatin regions of active genes, including enhancers and non-CpG islands . Epigenetics & Chromatin vol. 11 , ( 1 )

Guitart AV, Finch AJ, Kranc KR ( 2018 ) . Ca2+tapulting HSCs into action . Journal of Experimental Medicine vol. 215 , ( 8 ) 1971 - 1973 .

Pellicano F, Park L, Hopcroft LEM, Shah MM, Jackson L, Scott MT, Clarke CJ, Sinclair A et al. ( 2018 ) . hsa-mir183/EGR1–mediated regulation of E2F1 is required for CML stem/progenitor cell survival . Blood vol. 131 , ( 14 ) 1532 - 1544 .

O'Duibhir E, Paris J, Lawson H, Sepulveda C, Shenton DD, Carragher NO, Kranc KR ( 2018 ) . Machine Learning Enables Live Label-Free Phenotypic Screening in Three Dimensions . Assay and Drug Development Technologies vol. 16 , ( 1 ) 51 - 63 .

Guitart AV, Panagopoulou TI, Villacreces A, Vukovic M, Sepulveda C, Allen L, Carter RN, van de Lagemaat LN et al. ( 2017 ) . Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions . Journal of Experimental Medicine vol. 214 , ( 3 ) 719 - 735 .

Woodward J, Taylor GC, Boyle S, Sie D, Read D, Chathoth K, Vukovic M, Tarrats N et al. ( 2016 ) . Condensin II mutation causes T-cell lymphoma through tissue-specific genome instability . Genes & Development vol. 30 , ( 19 ) 2173 - 2186 .

Sinclair A, Park L, Shah M, Drotar M, Calaminus S, Hopcroft LEM, Kinstrie R, Guitart AV et al. ( 2016 ) . CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells . Blood vol. 128 , ( 3 ) 371 - 383 .

Karvela M, Baquero P, Kuntz EM, Mukhopadhyay A, Mitchell R, Chan E, Kranc KR, Calabretta B et al. ( 2016 ) . ATG7 regulates energy metabolism, differentiation and survival of Philadelphia-chromosome-positive cells . Autophagy vol. 12 , ( 6 ) 936 - 948 .

Vukovic M, Sepulveda C, Subramani C, Guitart AV, Mohr J, Allen L, Panagopoulou TI, Paris J et al. ( 2016 ) . Adult hematopoietic stem cells lacking Hif-1α self-renew normally . Blood vol. 127 , ( 23 ) 2841 - 2846 .

Vukovic M, Guitart AV, Sepulveda C, Villacreces A, O'Duibhir E, Ivens A, Menendez-Gonzalez J, Allen L et al. ( 2015 ) . Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance . Journal of Experimental Medicine vol. 212 , ( 13 ) 2223 - 2234 .

Guitart AV, Vukovic M, Sepulveda C, Panagopoulou T, Allen L, Pollard P, Morton N ( 2015 ) . Dual function of fumarate hydratase in haematopoietic stem cell fates . Experimental Hematology . vol. 43 ,

Kranc KR, Dzierzak E ( 2015 ) . Relieving oxidative stress in immune cells . Journal of Experimental Medicine vol. 212 , ( 8 ) 1140 - 1140 .

Kranc KR, Oliveira DV, Armesilla-Diaz A, Pacheco-Leyva I, Matias AC, Escapa AL, Subramani C, Wheadon H et al. ( 2015 ) . Acute Loss of Cited2 Impairs Nanog Expression and Decreases Self‐Renewal of Mouse Embryonic Stem Cells . Stem Cells vol. 33 , ( 3 ) 699 - 712 .

Guitart AV, Vukovic M, Sas Z, Vila M, Sepulveda C, Panagopoulou T, Allen L, Pollard P et al. ( 2015 ) . FUMARATE HYDRATASE IS AN ESSENTIAL REGULATOR OF EMBRYONIC AND ADULT HAEMATOPOIETIC STEM CELL . HAEMATOLOGICA . vol. 100 , 123 - 123 .

Vukovic M, Guitart AV ( 2015 ) . HIF-2A IS A TUMOUR SUPPRESSOR IN AML . HAEMATOLOGICA . vol. 100 , 10 - 10 .

Sepulveda C, Guitart A, Panagopoulou TI, Lengelling A, Ratcliffe PJ ( 2015 ) . THE ROLE OF 2-OXOGLUTARATE DEPENDENT DIOXYGENASES IN NORMAL HAEMATOPOIESIS AND ACUTE MYELOID LEUKEMIA . HAEMATOLOGICA . vol. 100 , 9 - 9 .

Yang M, Su H, Soga T, Kranc KR ( 2014 ) . Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism . Hypoxia vol. 2 , ( 0 ) 127 - 142 .

Gezer D, Vukovic M, Soga T, Pollard PJ ( 2014 ) . Concise Review: Genetic Dissection of Hypoxia Signaling Pathways in Normal and Leukemic Stem Cells . Stem Cells vol. 32 , ( 6 ) 1390 - 1397 .

Gezer D, Guitart AV, Vukovic M, Subramani C, Dunn K, Pollard P, Ratcliffe PJ, Holyoake TL et al. ( 2013 ) . HIF-1α Is Not Essential For The Establishment Of MLL-Leukaemic Stem Cells . Blood vol. 122 , ( 21 )

Guitart AV, Subramani C, Armesilla-Diaz A, Smith G, Sepulveda C, Gezer D, Vukovic M, Dunn K et al. ( 2013 ) . Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance . Blood vol. 122 , ( 10 ) 1741 - 1745 .

Calaminus SDJ, Guitart AV, Sinclair A, Watson SP, Holyoake TL ( 2013 ) . Correction: Lineage Tracing of Pf4-Cre Marks Hematopoietic Stem Cells and Their Progeny . PLOS ONE vol. 8 , ( 5 )

Sinclair A, Calaminus S, Pellicano F, Guitart A, Graham S, Poncz M, Graham G, Sansom O ( 2013 ) . CHEMOKINE SIGNALLING REGULATES HAEMOPOIETIC STEM CELL SURVIVAL . HAEMATOLOGICA . vol. 98 , 391 - 392 .

Guitart A, Pollard P, Holyoake T, Enver T, Kranc K ( 2013 ) . HIF-1ALPHA AND HIF-2APLPHA ARE NOT ESSENTIAL FOR STEADY-STATE HEMATOPOIETIC STEM CELL MAINTENANCE . HAEMATOLOGICA . vol. 98 , 493 - 493 .

Calaminus SDJ, Guitart A, Sinclair A, Schachtner H, Holyoake TL, Kranc KR ( 2012 ) . Lineage Tracing of Pf4-Cre Marks Hematopoietic Stem Cells and Their Progeny . PLOS ONE vol. 7 , ( 12 )

Sinclair A, Pellicano P, Graham SM, Kinstrie R, Kranc K ( 2012 ) . An investigation of the role of CXCL1-CXCR2 signalling in haemopoietic stem cell quiescence . BRITISH JOURNAL OF HAEMATOLOGY . vol. 157 , 26 - 27 .

Mortensen M, Soilleux EJ, Djordjevic G, Tripp R, Lutteropp M, Sadighi-Akha E, Stranks AJ, Knight S ( 2011 ) . The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance . Journal of Cell Biology vol. 192 , ( 5 ) i5 - i5 .

Mortensen M, Soilleux EJ, Djordjevic G, Tripp R, Sadighi-Akha E, Stranks AJ, Knight S, Jacobsen S-EW ( 2011 ) . The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance . Journal of Experimental Medicine vol. 208 , ( 3 ) 455 - 467 .

Pollard PJ ( 2010 ) . Hypoxia Signaling in Hematopoietic Stem Cells: A Double-Edged Sword . Cell Stem Cell vol. 7 , ( 3 ) 276 - 278 .

Kranc KR, Schepers H, Rodrigues NP, Bamforth S, Villadsen E, Ferry H, Bouriez-Jones T ( 2009 ) . Cited2 Is an Essential Regulator of Adult Hematopoietic Stem Cells . Cell Stem Cell vol. 5 , ( 6 ) 659 - 665 .

Harkiolaki M, Holmes SL, Svendsen P, Gregersen JW, McMahon R, Friese MA, Etzensperger R, Tzartos JS et al. ( 2009 ) . T Cell-Mediated Autoimmune Disease Due to Low-Affinity Crossreactivity to Common Microbial Peptides . Immunity vol. 30 , ( 4 )

Harkiolaki M, Holmes SL, Svendsen P, Gregersen JW, Jensen LT, Friese MA, van Boxel G, Etzensperger R et al. ( 2009 ) . T Cell-Mediated Autoimmune Disease Due to Low-Affinity Crossreactivity to Common Microbial Peptides . Immunity vol. 30 , ( 3 ) 348 - 357 .

Gregersen JW, Kranc KR, Ke X, Madsen LS, Thomsen AR ( 2006 ) . Functional epistasis on a common MHC haplotype associated with multiple sclerosis . Nature vol. 443 , ( 7111 ) 574 - 577 .

Clark JF, Kranc KR ( 2005 ) . The role of the mitochondrion in smooth muscle cell fate choices of proliferation versus apoptosis during vascular and cardiovascular diseases . Expert Opinion on Therapeutic Targets vol. 3 , ( 4 ) 513 - 525 .

Kranc KR, Taylor AM, Willcox N ( 2005 ) . Control of autoimmunity by ‘epitope theft’ . Trends in Molecular Medicine vol. 11 , ( 1 ) 1 - 4 .

Kranc KR, Pyne GJ, Tao L, Claridge TDW, Cadoux‐Hudson TAD, Turnbull JJ, Schofield CJ ( 2001 ) . Oxidative degradation of bilirubin produces vasoactive compounds . The FEBS Journal vol. 267 , ( 24 ) 7094 - 7101 .

Bamforth SD, Bragança J, Eloranta JJ, Marques FIR, Hurst HC, Bhattacharya S ( 2001 ) . Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator . Nature Genetics vol. 29 , ( 4 ) 469 - 474 .

Clark JF, Pyne GJ, Claridge T, Harris D, Kranc K, Schofield C ( 2001 ) . Oxidative degradation of bilirubin produces vasoactive compounds in subarachnoid hemorrhage patients with cerebral vasospasm . FASEB JOURNAL . vol. 15 , A112 - A112 .

Kucinski I, Campos J, Barile M, Severi F, Bohin N, Moreira PN, Allen L, Lawson H et al. . A time and single-cell resolved model of hematopoiesis .

Ragusa D, Suen C-W, Torregrosa-Cortés G, Pastorino F, Johns A, Cicirò Y, Dijkhuis L, van den Brink S et al. . Dissecting infant leukemia developmental origins with a hemogenic gastruloid model .

Mirchandani AS, Jenkins SJ, Bain CC, Lawson H, Coelho P, Murphy F, Griffith D, Zhang A et al. . Hypoxia shapes the immune landscape in lung injury promoting inflammation persistence .

Abdelfattah A, Habib A, Thomas L-A, Menendez-Gonzalez JB, Almotiri A, Alqahtani H, Lawson H, Taha S et al. . Impaired DNA damage response and inflammatory signalling underpins hematopoietic stem cell defects in Gata2 haploinsufficiency .

Woodley K, Dillingh LS, Giotopoulos G, Madrigal P, Rattigan KM, Philippe C, Dembitz V, Magee AMS et al. . Mannose metabolism inhibition sensitizes acute myeloid leukemia cells to cytarabine and FLT3 inhibitor therapy by modulating fatty acid metabolism to drive ferroptotic cell death .

Young C, Russell JR, Lawson H, Mapperley C, Kranc KR, Christophorou MA . Peptidylarginine deiminase IV (PADI4) is not essential for cell-autonomous HSC maintenance and normal haematopoiesis .

Dembitz V, Lawson H, Burt R, Philippe C, James SC, Atkinson S, Durko J, Wang LM et al. . SCD inhibition preferentially eradicates AML displaying high de novo fatty acid desaturation and synergizes with chemotherapy .

Turner DJ, Saveliev A, Salerno F, Matheson LS, Screen M, Lawson H, Wotherspoon D, Kranc KR et al. . The RNA m6A binding protein YTHDF2 promotes the B cell to plasma cell transition .

Kranc K . The mRNA m6A reader YTHDF2 supresses pro-inflammatory pathways and sustains hematopoietic stem cell function . Journal of Experimental Medicine