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  1. Queen Mary University of London
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Publications: PROF Pradeepa Madapura Marulasiddappa

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Summan S, Patel M, Madapura P, Shah F, Mayes A, Gunn D, Gautrot J, Caley M et al. ( 2025 ) . 248 Exploring the Effect of Skin Ageing-Related Basement Membrane Collagen Loss on Nuclear Mechanics . Journal of Investigative Dermatology vol. 145 , ( 12 )
Milan M, Runfola V, Patel M, Falbo L, Noberini R, Soriani C, Rodighiero S, Bonaldi T et al. ( 2025 ) . Mammalian H4K16ac regulates the spatiotemporal order of genome replication rather than gene expression . Nucleic Acids Research vol. 53 , ( 18 )
Jacob DR, Guiblet WM, Mamayusupova H, Shtumpf M, Ciuta I, Ruje L, Gretton S, Bikova M et al. ( 2024 ) . Nucleosome reorganisation in breast cancer tissues . Clinical Epigenetics vol. 16 , ( 1 )
Jayakumar S, Patel M, Boulet F, Aziz H, Brooke GN, Tummala H, Pradeepa MM ( 2024 ) . PSIP1/LEDGF reduces R-loops at transcription sites to maintain genome integrity . Nature Communications vol. 15 , ( 1 )
Pal D, Patel M, Boulet F, Sundarraj J, Grant OA, Branco MR, Basu S, Santos SDM et al. ( 2023 ) . H4K16ac activates the transcription of transposable elements and contributes to their cis-regulatory function . Nature Structural & Molecular Biology vol. 30 , ( 7 ) 935 - 947 .
Pradeepa MM, Manjunatha S, Sathish V ( 2023 ) . Involvement of Importin-4 in the Transport of Transition Protein 2 into the Spermatid Nucleus . Molecular and Cellular Biology vol. 28 , ( 13 ) 4331 - 4341 .
De Vas MG, Boulet F, Joshi SS, Garstang MG, Khan TN, Atla G, Parry D, Cebola I et al. ( 2023 ) . Regulatory de novo mutations underlying intellectual disability . Life Science Alliance vol. 6 , ( 5 )
Rodriguez-Algarra F, Seaborne RAE, Danson AF, Yildizoglu S, Yoshikawa H, Law PP, Ahmad Z, Maudsley VA et al. ( 2022 ) . Genetic variation at mouse and human ribosomal DNA influences associated epigenetic states . Genome Biology vol. 23 , ( 1 )
Sundarraj J, Taylor GCA, von Kriegsheim A ( 2021 ) . H3K36me3 and PSIP1/LEDGF associate with several DNA repair proteins, suggesting their role in efficient DNA repair at actively transcribing loci . Wellcome Open Research vol. 2 ,
Sundarraj J, Taylor GCA, von Kriegsheim A ( 2021 ) . H3K36me3 and PSIP1/LEDGF associate with several DNA repair proteins, suggesting their role in efficient DNA repair at actively transcribing loci . Wellcome Open Research vol. 2 ,
Olley G, Pradeepa MM, Grimes GR, Piquet S, Polo SE ( 2021 ) . Cornelia de Lange syndrome-associated mutations cause a DNA damage signalling and repair defect . Nature Communications vol. 12 , ( 1 )
Olley G, Ansari M, Bengani H, Grimes GR, Rhodes J, von Kriegsheim A, Blatnik A, Stewart FJ et al. ( 2019 ) . Publisher Correction: BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange–like syndrome . Nature Genetics vol. 51 , ( 7 ) 1192 - 1192 .
Garstang MG, Pradeepa MM ( 2018 ) . An Enhancer-Derived RNA Muscles In to Regulate Myogenin In trans . Mol Cell vol. 71 , ( 1 ) 3 - 5 .
Olley G, Ansari M, Bengani H, Grimes GR, Rhodes J, von Kriegsheim A, Blatnik A, Stewart FJ et al. ( 2018 ) . Publisher Correction: BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange–like syndrome . Nature Genetics vol. 50 , ( 5 ) 767 - 767 .
Olley G, Ansari M, Bengani H, Grimes GR, Rhodes J, von Kriegsheim A, Stewart FJ, Carroll N et al. ( 2018 ) . BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange–like syndrome . Nature Genetics vol. 50 , ( 3 ) 329 - 332 .
Marin R, Cortez D, Lamanna F, Pradeepa MM, Leushkin E, Julien P, Halbert J, Brüning T et al. ( 2017 ) . Convergent origination of a Drosophila-like dosage compensation mechanism in a reptile lineage . Genome Research vol. 27 , ( 12 ) 1974 - 1987 .
Pradeepa MM, Taylor GCA ( 2017 ) . ­­­Proteomic analysis of H3K36me3 and PSIP1/p75 (LEDGF) complexes reveal their wider role in DNA repair . Wellcome Open Research vol. 2 ,
Pradeepa MM, Taylor GCA ( 2017 ) . ­­­Proteomic analysis of H3K36me3 and PSIP1/p75 (LEDGF) complexes reveal their wider role in DNA repair . Wellcome Open Research vol. 2 ,
Pradeepa MM, Taylor GCA, Bengani H, Wood AJ, Bhatia S, Bickmore WA ( 2017 ) . Psip1/p52 regulates posterior Hoxa genes through activation of lncRNA Hottip . PLOS Genetics vol. 13 , ( 4 )
Pradeepa MM ( 2017 ) . Causal role of histone acetylations in enhancer function . Transcription vol. 8 , ( 1 ) 40 - 47 .
Marulasiddappa P, Pradeepa MM, Kumar Y, Grimes G, Illingworth R ( 2016 ) . Native chromatin immunoprecipitation of histone marks to Identify enhancer status . Protocol Exchange
Pradeepa MM, Grimes GR, Kumar Y, Olley G, Taylor GCA, Schneider R, Bickmore WA ( 2016 ) . Histone H3 globular domain acetylation identifies a new class of enhancers . Nature Genetics vol. 48 , ( 6 ) 681 - 686 .
Robertson KA, Hsieh WY, Forster T, Blanc M, Lu H, Crick PJ, Yutuc E, Watterson S et al. ( 2016 ) . An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway . PLOS Biology vol. 14 , ( 3 )
Illingworth RS, Moffat M, Mann AR, Read D, Hunter CJ, Pradeepa MM ( 2015 ) . The E3 ubiquitin ligase activity of RING1B is not essential for early mouse development . Genes & Development vol. 29 , ( 18 ) 1897 - 1902 .
Gupta N, Madapura MP, Bhat UA, Rao MRS ( 2015 ) . Mapping of Post-translational Modifications of Transition Proteins, TP1 and TP2, and Identification of Protein Arginine Methyltransferase 4 and Lysine Methyltransferase 7 as Methyltransferase for TP2* . Journal of Biological Chemistry vol. 290 , ( 19 ) 12101 - 12122 .
Pradeepa MM, Grimes GR, Sutherland HG ( 2014 ) . Psip1/Ledgf p75 restrains Hox gene expression by recruiting both trithorax and polycomb group proteins . Nucleic Acids Research vol. 42 , ( 14 ) 9021 - 9032 .
Taylor GCA, Eskeland R, Hekimoglu-Balkan B, Pradeepa MM ( 2013 ) . H4K16 acetylation marks active genes and enhancers of embryonic stem cells, but does not alter chromatin compaction . Genome Research vol. 23 , ( 12 ) 2053 - 2065 .
Pradeepa MM, Sutherland HG, Ule J, Grimes GR ( 2012 ) . Psip1/Ledgf p52 Binds Methylated Histone H3K36 and Splicing Factors and Contributes to the Regulation of Alternative Splicing . PLOS Genetics vol. 8 , ( 5 )
Pradeepa MM, Nikhil G, Kishore AH, Bharath GN, Rao MRS ( 2009 ) . Acetylation of Transition Protein 2 (TP2) by KAT3B (p300) Alters Its DNA Condensation Property and Interaction with Putative Histone Chaperone NPM3* . Journal of Biological Chemistry vol. 284 , ( 43 ) 29956 - 29967 .
Kolthur-Seetharam U, Pradeepa MM, Gupta N, Rao MRS ( 2009 ) . Spatiotemporal Organization of AT- and GC-rich DNA and Their Association With Transition Proteins TP1 and TP2 in Rat Condensing Spermatids . Journal of Histochemistry & Cytochemistry vol. 57 , ( 10 ) 951 - 962 .
Pradeepa MM, Rao MRS ( 2007 ) . Chromatin remodeling during mammalian spermatogenesis: role of testis specific histone variants and transition proteins . Society of Reproduction and Fertility vol. 63 , 1 - 10 .
Dhar S, Pradeepa MM, Rao MRS ( 2007 ) . Emerging concepts of chromatin remodeling in modulating genome functions . PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES INDIA SECTION B-BIOLOGICAL SCIENCES vol. 77 , 61 - 71 .
. BRD4 represses developmental and neuronal genes through interactions with polycomb complexes .
Olley G, Pradeepa MM, FitzPatrick DR, Bickmore WA, Boumendil C . Cornelia-de Lange syndrome-associated mutations cause a DNA damage signalling and repair defect .
De Vas MG, Garstang MG, Joshi SS, Khan TN, Atla G, Parry D, Moore D, Cebola I et al. . De novo variants in population constrained fetal brain enhancers and intellectual disability .
Pradeepa M, Patel M, Ali A, Dabrowska A, Boulet F, Kulkarni R, Ince C, Sinha A . De-repression of Transposable Elements by Histone Hyperacetylation Leads to Sterile Inflammation in Preeclampsia .
Patel M, Ali AS, Dabrowska A, Boulet F, Sinha AK, Pradeepa MM . Early Prediction of Preeclampsia Based on Transposable Elements signature in cell-free RNA .
Rodriguez-Algarra F, Seaborne RAE, Danson AF, Yildizoglu S, Yoshikawa H, Law PP, Ahmad Z, Maudsley VA et al. . Genetic variation at mouse and human ribosomal DNA influences associated epigenetic states .
Pal D, Patel M, Boulet F, Sundarraj J, Grant OA, Branco MR, Basu S, Santos S et al. . H4K16ac activates the transcription of transposable elements and contributes to their cis-regulatory function .
Cao Y, Dovgusha O, Ebrahimi A, Bevan S, Widmer L, Torabi F, Kurlovich J, Rodríguez-Polo I et al. . Non-canonical enhancers control gene expression and cell fate in human pluripotent stem cells .
Patel MB, Maniati E, Atanur SS, Pal D, Rio-Machin A, Heward J, Kocher HM, Fitzgibbon J et al. . Non-coding mutations at enhancer clusters contribute to pancreatic ductal adenocarcinoma .
Jacob DR, Guiblet WM, Mamayusupova H, Shtumpf M, Ciuta I, Ruje L, Gretton S, Bikova M et al. . Nucleosome reorganisation in breast cancer tissues .
Jayakumar S, Patel M, Boulet F, Aziz H, Brooke GN, Tummala H, Pradeepa MM . PSIP1/LEDGF reduces R-loops at transcription sites to maintain genome integrity .
Pradeepa MM, Taylor G, Grimes GR, Wood AJ, Bickmore WA . Psip1/p52 regulates distal Hoxa genes through activation of lncRNA Hottip .
De Vas MG, Boulet F, Joshi SS, Garstang MG, Khan TN, Atla G, Parry D, Moore D et al. . Regulatory de novo mutations underlying intellectual disability .
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