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  1. Queen Mary University of London
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Publications: DR Bella Kotantaki

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Joy JD, Malacrida B, Laforêts F, Kotantaki P, Maniati E, Manchanda R, Annibaldi A, Hopkins S et al. ( 2024 ) . Human 3D Ovarian Cancer Models Reveal Malignant Cell–Intrinsic and –Extrinsic Factors That Influence CAR T-cell Activity . Cancer Research vol. 84 , ( 15 ) 2432 - 2449 .
Joy JD, Malacrida B, Laforets F, Kotantaki P, Maniati E, Manchanda R, Hopkins S, Garrobo-Calleja I et al. ( 2024 ) . Abstract B079: Human 3D ovarian cancer models reveal malignant cell intrinsic and extrinsic factors that influence CAR-T cell activity . Cancer Research vol. 84 , ( 5_Supplement_2 ) b079 - b079 .
Joy JD, Malacrida B, Laforêts F, Kotantaki P, Maniati E, Hopkins S, Garrobo-Calleja I, Gautrot J et al. ( 2023 ) . Abstract 4576: 3D in vitro models uncover malignant cell intrinsic and extrinsic mechanisms of CAR-T cell resistance in high grade serous ovarian cancer . Cancer Research vol. 83 , ( 7_Supplement ) 4576 - 4576 .
Laforets F, Kotantaki P, Malacrida B, Elorbany S, Manchanda R, Donnadieu E, Balkwill F ( 2023 ) . Abstract 5913: Semi-supervised analysis of myeloid and T cell behavior in ex vivo ovarian tumor slices reveals changes in cell motility after treatments . Cancer Research . vol. 83 , 5913 - 5913 .
Kotantaki P, Laforêts F, Maniati E, Berlato C, Malliouri A, Devlin MJ, Malacrida B, Elorbany S et al. ( 2023 ) . Abstract 5957: Chemotherapy-induced extracellular matrix remodeling in HGSOC . Cancer Research . vol. 83 , 5957 - 5957 .
Laforêts F, Kotantaki P, Malacrida B, Elorbany S, Manchanda R, Donnadieu E, Balkwill F ( 2023 ) . Semi-supervised analysis of myeloid and T cell behavior in ex vivo ovarian tumor slices reveals changes in cell motility after treatments . iScience vol. 26 , ( 4 )
Devlin M-J, Miller R, Laforets F, Kotantaki P, Garsed DW, Kristeleit R, Bowtell DD, McDermott J et al. ( 2022 ) . The tumour microenvironment of clear cell ovarian cancer . Cancer Immunology Research vol. 10 , ( 11 ) 1326 - 1339 .
Joy JD, Malacrida B, Laforêts F, Kotantaki P, Maniati E, Hopkins S, Calleja I, Brett S et al. ( 2022 ) . Abstract 693: TGFβ-mediated targeting of the extracellular matrix enhances the migration and cytotoxicity of CAR-T cells in 3D models of ovarian cancer . Cancer Research vol. 82 , ( 12_Supplement ) 693 - 693 .
Murray ER, Menezes S, Henry JC, Williams JL, Alba-Castellón L, Baskaran P, Quétier I, Desai A et al. ( 2022 ) . Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion . Cell Reports vol. 38 , ( 4 )
Laforêts F, Kotantaki P, Malacrida B, Elorbany S, Manchanda R, Donnadieu E, Balkwill F ( 2022 ) . Semi-Supervised Analysis of Myeloid and T Cell Behaviour in ex vivo Ovarian Tumour Slices Reveals Changes in Cell Motility After Treatments .
Joy JD, Malacrida B, Laforets F, Kotantaki P, Maniati E, Hopkins S, Calleja I, Brett S et al. ( 2022 ) . TGFß-mediated targeting of the extracellular matrix enhances the migration and cytotoxicity of CAR-T cells in 3D models of ovarian cancer . CANCER RESEARCH . vol. 82 ,
Berlato C, Heath O, Maniati E, Gopinathan G, Kotantaki P, Elorbany S, McDermott J, Pegrum C et al. ( 2021 ) . Abstract 2745: Murine high grade serous ovarian cancer (HGSOC) models replicate the human tumor microenvironment and suggest anti-tumor activities of macrophages after chemotherapy . Cancer Research . vol. 81 , 2745 - 2745 .
Devlin M-J, Kristeleit RS, McDermott J, Maniati E, Laforêts F, Kotantaki P, Miller R, Balkwill F ( 2021 ) . Abstract 2748: Impact of ARID1A mutation on the tumor microenvironment of advanced clear cell ovarian cancer . Cancer Research . vol. 81 , 2748 - 2748 .
Heath O, Berlato C, Maniati E, Lakhani A, Pegrum C, Kotantaki P, Elorbany S, Böhm S et al. ( 2021 ) . Chemotherapy Induces Tumor-Associated Macrophages that Aid Adaptive Immune Responses in Ovarian Cancer . Cancer Immunology Research vol. 9 , ( 6 ) 665 - 681 .
Maniati E, Berlato C, Gopinathan G, Heath O, Kotantaki P, Lakhani A, McDermott J, Pegrum C et al. ( 2020 ) . Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment . Cell Reports vol. 30 , ( 2 ) 525 - 540.e7 .
Maniati E, Berlato C, Gopinathan G, Heath O, Kotantaki P, Lakhani A, McDermott J, Pegrum C et al. ( 2019 ) . Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment .
( 2016 ) . The expression of tumor suppressor gene Cyld is upregulated by histone deacetylace inhibitors in human hepatocellular carcinoma cell lines . Cell Biochemistry and Function vol. 34 , ( 7 ) 465 - 468 .
( 2016 ) . Inactivation of CYLD in intestinal epithelial cells exacerbates colitis-associated colorectal carcinogenesis - a short report . Cellular Oncology vol. 39 , ( 3 ) 287 - 293 .
( 2014 ) . Geminin deletion increases the number of fetal hematopoietic stem cells by affecting the expression of key transcription factors . Development vol. 142 , ( 1 ) 70 - 81 .
( 2014 ) . Life without geminin . Cell Cycle vol. 9 , ( 16 ) 3201 - 3205 .
( 2012 ) . Reduced Geminin levels promote cellular senescence . Mechanisms of Ageing and Development vol. 134 , ( 1-2 ) 10 - 23 .
( 2011 ) . T Cell Proliferation and Homeostasis: An Emerging Role for the Cell Cycle Inhibitor Geminin . Critical Reviews in Immunology vol. 31 , ( 3 ) 209 - 231 .
( 2010 ) . Differential Geminin Requirement for Proliferation of Thymocytes and Mature T Cells . The Journal of Immunology vol. 184 , ( 5 ) 2432 - 2441 .
( 2008 ) . Cdt1 and Geminin in cancer: markers or triggers of malignant transformation? . Frontiers in Bioscience-Landmark vol. 13 , ( 13 ) 4485 - 4494 .
( 2007 ) . Licensing regulators Geminin and Cdt1 identify progenitor cells of the mouse CNS in a specific phase of the cell cycle . Neuroscience vol. 147 , ( 2 ) 373 - 387 .
( 2006 ) . Investigating geminin's role in the immune system . Review of Clinical Pharmacology and Pharmacokinetics International Edition . vol. 20 , 216 - 219 .
Laforêts F, Kotantaki P, Elorbany S, Hartlebury J, Joy JD, Malacrida B, Bryan-Ravenscroft RC, Berlato C et al. . Matrix structure and microenvironment dynamics correlate with chemotherapy response in ovarian cancer .
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