Publications: Dr James Ruffle
Mole J, Ruffle JK, Nelson A, Chan E, Shallice T, Nachev P, Cipolotti L
(
2025
)
.
A right frontal network for analogical and deductive reasoning
.
Brain
vol.
148
,
(
5
)
1757
-
1768
.
Kilani Y, Gonzalez Mosquera DA, Puelo PC, Aldiabat M, Ruffle JK, Madi MY, Farmer AD
(
2025
)
.
The Impact of Cannabis Use in Gastroparesis: A Propensity-Matched Analysis of 41,374 Gastroparesis Patients
.
American Journal of Gastroenterology
Ahmed N, Dehbi H-M, Freemantle N, Best J, Nash PS, Ruffle JK, Doig D, Werring DJ
(
2025
)
.
Optimal timing of anticoagulation after acute ischaemic stroke with atrial fibrillation (OPTIMAS): statistical analysis plan for a randomised controlled trial
.
Trials
vol.
26
,
(
1
)
Article
58
,
Foulon C, Gray R, Ruffle JK, Best J, Xu T, Watkins H, Rondina J, Pombo G et al.
(
2025
)
.
Generalizable automated ischaemic stroke lesion segmentation with vision transformers
.
Cipolotti L, Mole J, Ruffle JK, Nelson A, Gray R, Nachev P
(
2025
)
.
Cognitive control & the anterior cingulate cortex: Necessity & coherence
.
Cortex
vol.
182
,
87
-
99
.
(
2024
)
.
A machine learning approach to stratify patients with hypermobile Ehlers‐Danlos syndrome/hypermobility spectrum disorders according to disorders of gut brain interaction, comorbidities and quality of life
.
Neurogastroenterology & Motility
vol.
37
,
(
1
)
Article
e14957
,
Tariq M, Ruffle J, Mohinta S, Brothwell MRS, Brandner S, Nachev P, Hyare H
(
2024
)
.
P10.21.A MODELLING GBM RECURRENCE - THE INFLUENCE OF PERI-LESIONAL OEDEMA AND THE DISCONNECTOME
.
Neuro-Oncology
vol.
26
,
(
Supplement_5
)
v60
-
v60
.
Tan ML, Ruffle DJ, Mohinta MS, Rees DJ, Brandner PS, Nachev PP, Hyare DH
(
2024
)
.
MATHEMATICAL MODELLING OF SURVIVAL IN LOW GRADE GLIOMAS AT MALIGNANT TRANSFORMATION WITH XGBOOST
.
Neuro-Oncology
vol.
26
,
(
Supplement_7
)
vii12
-
vii13
.
Tariq MM, Ruffle DJ, Mohinta MS, Brothwell DM, Brandner PS, Nachev PP, Hyare H
(
2024
)
.
MODELLING GBM RECURRENCE: THE INflUENCE OF PERI-LESIONAL OEDEMA AND THE DISCONNECTOME
.
Neuro-Oncology
vol.
26
,
(
Supplement_7
)
vii4
-
vii4
.
Ruffle DJ, Mohinta MS, Baruteau DKP, Rajiah DR, Lee MF, Brandner PS, Nachev PP, Hyare DH
(
2024
)
.
VASARI-AUTO: PERFORMANT, EQUITABLE, EffiCIENT, ECONOMIC, AND SURVIVAL PREDICTIVE FEATURISATION OF GLIOMA MRI
.
Neuro-Oncology
vol.
26
,
(
Supplement_7
)
vii10
-
vii10
.
Pandit AS, China M, Jain R, Jalal AHB, Jelen M, Joshi SB, Skye C, Abdi Z et al.
(
2024
)
.
The utility of MRI radiological biomarkers in determining intracranial pressure
.
Scientific Reports
vol.
14
,
(
1
)
Article
23238
,
Nelson APK, Mole J, Pombo G, Gray RJ, Ruffle JK, Chan E, Rees GE, Cipolotti L et al.
(
2024
)
.
The minimal computational substrate of fluid intelligence
.
Cortex
vol.
179
,
62
-
76
.
Ruffle JK, Watkins H, Gray RJ, Hyare H, Thiebaut de Schotten M, Nachev P
(
2024
)
.
Compressed representation of brain genetic transcription
.
Human Brain Mapping
vol.
45
,
(
11
)
Article
e26795
,
Ruffle J, Henderson M, Ng CE, Liddle T, Nelson A, Nachev P, Knowles C, Yiannakou Y
(
2024
)
.
O62 The lived experience of functional bowel disorders: a machine learning approach
.
Oral Presentations
.
Conference:
BSG LIVE’24, 17-20 June 2024, ICC BirminghamA38
-
A39
.
Ruffle JK, Gray RJ, Mohinta S, Pombo G, Kaul C, Hyare H, Rees G, Nachev P
(
2024
)
.
Computational limits to the legibility of the imaged human brain
.
NeuroImage
vol.
291
,
Article
120600
,
120600
-
120600
.
Ruffle JK, Mohinta S, Baruteau KP, Rajiah R, Lee F, Brandner S, Nachev P, Hyare H
(
2024
)
.
VASARI-auto: equitable, efficient, and economical featurisation of\n glioma MRI
.
Ruffle JK, Henderson M, Ng CE, Liddle T, Nelson APK, Nachev P, Knowles CH, Yiannakou Y
(
2024
)
.
Deep phenotyping of patient lived experience in functional bowel disorders
.
Topan R, Pandya S, Williams S, Ruffle JK, Zarate-Lopez N, Aziz Q, Fikree A
(
2024
)
.
Comprehensive Assessment of Nutrition and Dietary Influences in Hypermobile Ehlers-Danlos Syndrome—A Cross-Sectional Study
.
American Journal of Gastroenterology
vol.
119
,
(
4
)
727
-
738
.
Ruffle JK, Mohinta S, Baruteau KP, Rajiah R, Lee F, Brandner S, Nachev P, Hyare H
(
2024
)
.
VASARI-auto: Equitable, efficient, and economical featurisation of glioma MRI
.
NeuroImage: Clinical
vol.
44
,
Article
103668
,
103668
-
103668
.
Giles D, Gray R, Foulon C, Pombo G, Xu T, Ruffle JK, Jäger HR, Cardoso J et al.
(
2023
)
.
InterSynth: A Semi-Synthetic Framework for Benchmarking Prescriptive Inference from Observational Data
.
Lecture Notes in Computer Science
,
Springer Nature Switzerland
Ruffle JK, Watkins H, Gray RJ, Hyare H, Schotten MTD, Nachev P
(
2023
)
.
Compressed representation of brain genetic transcription
.
Lee F, Ruffle J, Mohinta S, Kopanitsa V, Nachev P, Hyare H
(
2023
)
.
AUTOMATED VASARI FEATURE SET REPORTING FOR GLIOMAS IS EffCIENT AND EFFECTIVE
.
Neuro-Oncology
vol.
25
,
(
Supplement_3
)
iii18
-
iii19
.
Ruffle J, Mohinta S, Pombo G, Gray R, Kopanitsa V, Lee F, Brandner S, Hyare H et al.
(
2023
)
.
BRAIN TUMOUR GENETIC NETWORK SIGNATURES SUPERIORLY FORECAST SURVIVAL
.
Neuro-Oncology
vol.
25
,
(
Supplement_3
)
iii3
-
iii3
.
Ruffle J, Mohinta S, Brandner S, Hyare H, Nachev P
(
2023
)
.
DEMOGRAPHICS, GENETICS, AND EPIGENETICS INflUENCE THE LESION DISTRIBUTION OF GLIOMA
.
Neuro-Oncology
vol.
25
,
(
Supplement_3
)
iii4
-
iii4
.
Tan L, Ruffle J, Rees J, Kosmin M, Nachev P, Hyare H
(
2023
)
.
MATHEMATICAL MODELLING OF SURVIVAL IN LOW GRADE GLIOMAS AT MALIGNANT TRANSFORMATION
.
Neuro-Oncology
vol.
25
,
(
Supplement_3
)
iii19
-
iii19
.
Ruffle JK, Mohinta S, Pombo G, Gray R, Kopanitsa V, Lee F, Brandner S, Hyare H et al.
(
2023
)
.
Brain tumour genetic network signatures of survival
.
Brain
vol.
146
,
(
11
)
4736
-
4754
.
Ruffle JK, Gray RJ, Mohinta S, Pombo G, Kaul C, Hyare H, Rees G, Nachev P
(
2023
)
.
Computational limits to the legibility of the imaged human brain
.
Nelson AP, Mole J, Pombo G, Gray RJ, Ruffle JK, Chan E, Rees GE, Cipolotti L et al.
(
2023
)
.
The minimal computational substrate of fluid intelligence
.
Ruffle JK, Foulon C, Nachev P
(
2023
)
.
The human cost of ethical artificial intelligence
.
Brain Structure and Function
vol.
228
,
(
6
)
1365
-
1369
.
(
2023
)
.
An exploratory machine learning study on paediatric abdominal pain phenotyping and prediction
.
Ruffle JK, Mohinta S, Gray R, Hyare H, Nachev P
(
2023
)
.
Brain tumour segmentation with incomplete imaging data
.
Brain Communications
vol.
5
,
(
2
)
Article
fcad118
,
Pandit AS, China M, Jain R, Jalal AHB, Joshi SB, Skye C, Abdi Z, Aldabbagh Y et al.
(
2023
)
.
The utility of MRI radiological biomarkers in determining intracranial pressure
.
Elmalem MS, Moody H, Ruffle JK, de Schotten MT, Haggard P, Diehl B, Nachev P, Jha A
(
2023
)
.
A framework for focal and connectomic mapping of transiently disrupted brain function
.
Communications Biology
vol.
6
,
(
1
)
Article
430
,
Giles D, Gray R, Foulon C, Pombo G, Ruffle JK, Xu T, Jäger HR, Cardoso J et al.
(
2023
)
.
Individualized prescriptive inference in ischaemic stroke
.
Ruffle JK, Mohinta S, Pombo G, Gray R, Kopanitsa V, Lee F, Brandner S, Hyare H et al.
(
2023
)
.
Brain tumour genetic network signatures of survival
.
(
2023
)
.
Disorders of gut-brain interaction in patients with hypermobile Ehlers-Danlos syndrome/hypermobility spectrum disorders: Characterisation of co-morbidities and quality of life
.
NEUROGASTROENTEROLOGY AND MOTILITY
.
vol.
35
,
Topan R, Pandya S, Williams S, Ruffle J, Zarate-Lopez N, Aziz Q, Fikree A
(
2023
)
.
Positive screen for Avoidant-Restrictive Food Intake Disorder (ARFID) increases odds of artificial nutrition by four-fold in Hypermobile Ehlers-Danlos Syndrome (hEDS)
.
NEUROGASTROENTEROLOGY AND MOTILITY
.
vol.
35
,
Cipolotti L, Ruffle JK, Mole J, Xu T, Hyare H, Shallice T, Chan E, Nachev P
(
2022
)
.
Graph lesion-deficit mapping of fluid intelligence
.
Brain
vol.
146
,
(
1
)
167
-
181
.
Lim EA, Ruffle JK, Gnanadurai R, Lee H, Escobedo-Cousin M, Wall E, Cwynarski K, Heyderman RS et al.
(
2022
)
.
Author Correction: Differentiating central nervous system infection from disease infiltration in hematological malignancy
.
Scientific Reports
vol.
12
,
(
1
)
Article
21009
,
Ruffle J, Mohinta S, Pombo G, Gray R, Kopanitsa V, Lee F, Brandner S, Hyare H et al.
(
2022
)
.
CNSC-26. NETWORK SIGNATURES OF SURVIVAL IN BRAIN TUMOUR GENETICS
.
Neuro-Oncology
vol.
24
,
(
Supplement_7
)
vii27
-
vii28
.
Ruffle J, Mohinta S, Brandner S, Hyare H, Nachev P
(
2022
)
.
NIMG-35. THE DEEP TOPOLOGY OF GLIOMAS
.
Neuro-Oncology
vol.
24
,
(
Supplement_7
)
vii171
-
vii171
.
Carruthers R, Straw I, Ruffle JK, Herron D, Nelson A, Bzdok D, Fernandez-Reyes D, Rees G et al.
(
2022
)
.
Representational ethical model calibration
.
npj Digital Medicine
vol.
5
,
(
1
)
Article
170
,
Elmalem MS, Moody H, Ruffle JK, de Schotten MT, Haggard P, Diehl B, Nachev P, Jha A
(
2022
)
.
Focal and Connectomic Mapping of Transiently Disrupted Brain Function
.
(
2022
)
.
Brain effect of transcutaneous vagal nerve stimulation: A m<scp>eta‐analysis</scp> of neuroimaging evidence
.
Neurogastroenterology & Motility
vol.
36
,
(
8
)
Article
e14484
,
Ruffle J, Mohinta S, Gray R, Hyare H, Nachev P
(
2022
)
.
Deep Learning for Tumour Segmentation with Missing Data
.
Neuro-Oncology
vol.
24
,
(
Supplement_4
)
iv16
-
iv16
.
Ruffle J, Mohinta S, Gray R, Hyare H, Nachev P
(
2022
)
.
Identifying Enhancing Tumour Without Contrast-Enhanced Imaging
.
Neuro-Oncology
vol.
24
,
(
Supplement_4
)
iv3
-
iv3
.
Lim EA, Ruffle JK, Gnanadurai R, Lee H, Escobedo-Cousin M, Wall E, Cwynarski K, Heyderman RS et al.
(
2022
)
.
Differentiating central nervous system infection from disease infiltration in hematological malignancy
.
Scientific Reports
vol.
12
,
(
1
)
Article
15805
,
Cipolotti L, Ruffle JK, Mole J, Xu T, Hyare H, Shallice T, Chan E, Nachev P
(
2022
)
.
Graph lesion-deficit mapping of fluid intelligence
.
Carruthers R, Straw I, Ruffle JK, Herron D, Nelson A, Bzdok D, Fernandez-Reyes D, Rees G et al.
(
2022
)
.
Representational Ethical Model Calibration
.
Topan R, Williams S, Pandya S, Ruffle JK, Zarate-Lopez N, Aziz Q, Fikree A
(
2022
)
.
O57 Artificial nutrition use in hypermobile ehlers danlos syndrome: common with autonomic symptoms and disordered eating
.
Oral presentations
.
Conference:
Abstracts of the BSG Annual Meeting, 20–23 June 2022A32.2
-
A33
.
Topan R, Pandya S, Williams S, Ruffle JK, Zarate-Lopez N, Aziz Q, Fikree A
(
2022
)
.
P297 Altered diet in hypermobile ehlers danlos syndromeis predicted by upper gastrointestinal disorders and psychopathology
.
Poster presentations
.
Conference:
Abstracts of the BSG Annual Meeting, 20–23 June 2022A184.1
-
A184
.
Ruffle JK, Mohinta S, Gray RJ, Hyare H, Nachev P
(
2022
)
.
Brain tumour segmentation with incomplete imaging data
.
Takahashi K, Ruffle JK, Terai S, Satti H, Aziz Q
(
2022
)
.
537: CAN ARTIFICIAL INTELLIGENCE PREDICT THE DEVELOPMENT OF ABDOMINAL PAIN IN CHILDREN?
.
Gastroenterology
vol.
162
,
(
7
)
S
-
125
.
Nelson APK, Gray RJ, Ruffle JK, Watkins HC, Herron D, Sorros N, Mikhailov D, Cardoso MJ et al.
(
2022
)
.
Deep forecasting of translational impact in medical research
.
Patterns
vol.
3
,
(
5
)
Article
100483
,
100483
-
100483
.
(
2022
)
.
CAN ARTIFICIAL INTELLIGENCE PREDICT THE DEVELOPMENT OF ABDOMINAL PAIN IN CHILDREN?
.
GASTROENTEROLOGY
.
vol.
162
,
S125
-
S125
.
Ruffle J, Mohinta S, Pombo G, Gray R, Kopanitsa V, Lee F, Brandner S, Hyare H et al.
(
2022
)
.
NETWORK SIGNATURES OF SURVIVAL IN BRAIN TUMOUR GENETICS
.
NEURO-ONCOLOGY
.
vol.
24
,
27
-
28
.
Ruffle J, Mohinta S, Brandner S, Hyare H, Nachev P
(
2022
)
.
THE DEEP TOPOLOGY OF GLIOMAS
.
NEURO-ONCOLOGY
.
vol.
24
,
171
-
171
.
Nelson AP, Gray RJ, Ruffle JK, Watkins HC, Herron D, Sorros N, Mikhailov D, Cardoso MJ et al.
(
2021
)
.
Deep forecasting of translational impact in medical research
.
(
2021
)
.
The autonomic brain: Multi-dimensional generative hierarchical modelling of the autonomic connectome
.
Cortex
vol.
143
,
164
-
179
.
Lim EA, Gnanadurai R, Ruffle JK, Lee H, Miller RF, Hyare H
(
2021
)
.
Neuroimaging of CNS infection in haematological malignancy: important signs and common diagnostic pitfalls
.
Clinical Radiology
vol.
76
,
(
6
)
470.e1
-
470.e12
.
Ruffle J, Tinkler L, Emmett C, Ford A, Nachev P, Aziz Q, Farmer A, Yiannakou Y
(
2021
)
.
P342 Constipation-predominant irritable bowel syndrome and functional constipation are not discrete disorders: a machine learning approach
.
Posters
.
Conference:
Abstracts of the BSG Campus, 21–29 January 2021A218
-
A218
.
Rajiah R, Henderson M, Aziz Q, Yiannakou Y, Ruffle J
(
2021
)
.
Network modelling in chronic constipation
.
NEUROGASTROENTEROLOGY AND MOTILITY
.
vol.
33
,
Rajiah R, Takahashi K, Aziz Q, Ruffle J
(
2021
)
.
Transcutaneous vagal nerve stimulation as a potential treatment in functional gastrointestinal disorders: A meta-analysis of neuroimaging evidence
.
NEUROGASTROENTEROLOGY AND MOTILITY
.
vol.
33
,
Colecchia F, Ruffle JK, Pombo GC, Gray R, Hyare H, Nachev P
(
2020
)
.
Knowledge-driven deep neural network models for brain tumour segmentation
.
Journal of Physics: Conference Series
.
vol.
1662
,
012010
-
012010
.
(
2020
)
.
Constipation Predominant Irritable Bowel Syndrome and Functional Constipation Are Not Discrete Disorders: A Machine Learning Approach
.
American Journal of Gastroenterology
vol.
116
,
(
1
)
142
-
151
.
(
2020
)
.
Transcutaneous vagus nerve stimulation prevents the development of, and reverses, established oesophageal pain hypersensitivity
.
Alimentary Pharmacology & Therapeutics
vol.
52
,
(
6
)
988
-
996
.
Farmer AD, Wood E, Ruffle JK
(
2020
)
.
An approach to the care of patients with irritable bowel syndrome
.
Canadian Medical Association Journal
vol.
192
,
(
11
)
E275
-
E282
.
Ruffle JK, Farmer AD, Aziz Q
(
2020
)
.
Artificial intelligence in gastroenterology
.
Precision Medicine for Investigators, Practitioners and Providers
,
Elsevier
Ruffle JK, Farmer AD, Aziz Q
(
2020
)
.
Chapter 33 Artificial intelligence in gastroenterology
.
Precision Medicine for Investigators, Practitioners and Providers
,
Elsevier
Kanber B, Ruffle J, Cardoso J, Ourselin S, Ciccarelli O
(
2019
)
.
Neurosense: deep sensing of full or near-full coverage head/brain scans in human magnetic resonance imaging
.
Neuroinformatics
vol.
18
,
(
2
)
333
-
336
.
Farmer AD, Ruffle JK
(
2019
)
.
Irritable bowel syndrome
.
Medicine
vol.
47
,
(
6
)
350
-
353
.
(
2019
)
.
OWE-14 Symptom burden in chronic constipation is predicted by sensory domains, not stool frequency
.
Neurogastroenterology
.
Conference:
British Society of Gastroenterology Annual Meeting, 17–20 June 2019, AbstractsA205
-
A205
.
(
2019
)
.
PWE-097 Machine learning can accurately classify chronic constipation patients by symptom burden using pain measures alone
.
Posters
.
Conference:
British Society of Gastroenterology Annual Meeting, 17–20 June 2019, AbstractsA218
-
A219
.
Ruffle JK, Tinkler L, Emmett C, Aziz Q, Farmer AD, Yiannakou Y
(
2019
)
.
Su1630 – Sensory Domains, Not Stool Frequency, Predict a Higher Symptom Burden and a Reduction in Quality of Life in Chronic Constipation
.
Gastroenterology
vol.
156
,
(
6
)
S
-
590
.
Ruffle JK, Tinkler L, Emmett C, Aziz Q, Farmer AD, Yiannakou Y
(
2019
)
.
Su1631 – Machine Learning with Pain Measures Alone Can Accurately Classify Chronic Constipation Patients to High Or Low Total Symptom Burden
.
Gastroenterology
vol.
156
,
(
6
)
(
2019
)
.
Functional brain networks and neuroanatomy underpinning nausea severity can predict nausea susceptibility using machine learning
.
The Journal of Physiology
vol.
597
,
(
6
)
1517
-
1529
.
(
2019
)
.
Abdominal Pain Presenting as a Tight Squeeze on a Tchaikovsky Score
.
Gastroenterology
vol.
156
,
(
3
)
e3
-
e5
.
(
2019
)
.
MACHINE LEARNING WITH PAIN MEASURES ALONE CAN ACCURATELY CLASSIFY CHRONIC CONSTIPATION PATIENTS TO HIGH OR LOW TOTAL SYMPTOM BURDEN
.
GASTROENTEROLOGY
.
vol.
156
,
S590
-
S591
.
(
2019
)
.
SENSORY DOMAINS, NOT STOOL FREQUENCY, PREDICT A HIGHER SYMPTOM BURDEN AND A REDUCTION IN QUALITY OF LIFE IN CHRONIC CONSTIPATION
.
GASTROENTEROLOGY
.
vol.
156
,
S590
-
S590
.
Farmer AD, Ruffle JK, Hobson AR
(
2018
)
.
Linaclotide increases cecal pH, accelerates colonic transit, and increases colonic motility in irritable bowel syndrome with constipation
.
Neurogastroenterology & Motility
vol.
31
,
(
2
)
Article
e13492
,
Farmer AD, Ruffle JK, Barber M
(
2018
)
.
Moving <i>Neurogastroenterology</i><i>and Motility</i> into the social media age
.
Neurogastroenterology & Motility
vol.
30
,
(
11
)
Article
e13455
,
(
2018
)
.
Artificial Intelligence-Assisted Gastroenterology— Promises and Pitfalls
.
American Journal of Gastroenterology
vol.
114
,
(
3
)
422
-
428
.
(
2018
)
.
Systematic review with meta‐analysis: conditioned pain modulation in patients with the irritable bowel syndrome
.
Alimentary Pharmacology & Therapeutics
vol.
48
,
(
8
)
797
-
806
.
(
2018
)
.
Preliminary report: parasympathetic tone links to functional brain networks during the anticipation and experience of visceral pain
.
Scientific Reports
vol.
8
,
(
1
)
Article
13410
,
(
2018
)
.
OWE-026 Conditioned pain modulation in functional gastrointestinal disorders: systematic review & meta-analysis
.
Neurogastroenterology & motility
.
Conference:
British Society of Gastroenterology, Annual General Meeting, 4–7 June 2018, AbstractsA207
-
A207
.
(
2018
)
.
PWE-144 Susceptibility to nausea is concurrently associated with subcortical morphology and autonomic tone
.
Neurogastroenterology & motility
.
Conference:
British Society of Gastroenterology, Annual General Meeting, 4–7 June 2018, AbstractsA219.2
-
A220
.
(
2018
)
.
PWE-146 Pain endophenotypes display complex subcortical brain morphological differences influenced by autonomic neurophysiology or personality traits
.
Neurogastroenterology & motility
.
Conference:
British Society of Gastroenterology, Annual General Meeting, 4–7 June 2018, AbstractsA220.2
-
A221
.
Ruffle JK, Coen SJ, Giampietro V, Williams SC, Aziz Q, Farmer AD
(
2018
)
.
745 - Visceral Pain Endophenotypes Associate to Intricate Subcortical Brain Morphological Differences Contingent on Differing Autonomic Physiology or Personality
.
Gastroenterology
vol.
154
,
(
6
)
(
2018
)
.
Pronociceptive effects mediated by adenosinergic A2A activity at the nucleus accumbens, but what about the autonomic nervous system?
.
Pain
vol.
159
,
(
5
)
997
-
997
.
(
2018
)
.
Delineation between different components of chronic pain using dimension reduction – an <scp>ASL fMRI</scp> study in hand osteoarthritis
.
European Journal of Pain
vol.
22
,
(
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