Skip to main content
Research
  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: DR Suthesh Sivapalaratnam

Back to Search
Constantinescu-Bercu A, Smith KE, Wong SY, Ballerini M, Nastro A, Wiggins BG, Pirri D, Li Y et al. ( 2026 ) . Von Willebrand factor deficiency impairs angiogenesis via angiopoietin-2: relevance for gut angiodysplasia . Blood vol. 147 , ( 21 ) 2541 - 2553 .
Rutten KHG, Tsiamita O, Platton S, Fiore M, Urbanus RT, Sivapalaratnam S, Schutgens REG ( 2026 ) . The use of light transmission aggregometry for monitoring platelet transfusion response in a small case cohort of Glanzmann thrombasthenia patients: a hypothesis-generating study . Platelets vol. 37 , ( 1 )
Piazzese C, Williams S, Slabaugh G, Farren T, Freeman T, Aiken L, Dadhra J, Browne S et al. ( 2025 ) . BloodImage: Benchmarking vision transformers for blast detection in digital blood films using public and clinical datasets . Journal of Pathology Informatics vol. 19 ,
Rutten KHG, Tsiamita O, Van Thillo Q, Raheja P, Kaler M, van Galen KPM, Hogg M, Bowles L et al. ( 2025 ) . Management of pregnancy and childbirth in Glanzmann thrombasthenia: A case series and review . British Journal of Haematology vol. 207 , ( 4 ) 1702 - 1708 .
Kamali S, Dave M, Raheja P, Sivapalaratnam S, Platton S ( 2025 ) . Evaluation of International Council for Standardization in Haematology Recommendations on Activated Partial Thromboplastin Time Mixing Tests Using an Automated Haemostasis Analyser . International Journal of Laboratory Hematology vol. 47 , ( 6 ) 1178 - 1185 .
Platton S, Sivapalaratnam S, Raheja P ( 2024 ) . Platton S, Sivapalaratnam S, Raheja P. Diagnosis and laboratory monitoring of acquired hemophilia A. Hematology Am Soc Hematol Educ Program. 2023;2023(1):11-18 . Hematology vol. 2024 , ( 1 )
Platton S, Sivapalaratnam S, Raheja P ( 2023 ) . Diagnosis and laboratory monitoring of acquired hemophilia A . Hematology vol. 2023 , ( 1 ) 11 - 18 .
Platton S, Schönborn L, Charrot S, Badat M, McDonald V, Sivapalaratnam S, Bowles L ( 2021 ) . Vaccine‐induced immune thrombocytopenia and thrombosis: The decline in anti‐platelet factor 4 antibodies is assay‐dependent . British Journal of Haematology vol. 197 , ( 4 ) 428 - 430 .
Sims MC, Mayer L, Collins JH, Bariana TK, Megy K, Lavenu-Bombled C, Seyres D, Kollipara L et al. ( 2020 ) . Novel manifestations of immune dysregulation and granule defects in gray platelet syndrome . Blood vol. 136 , ( 17 ) 1956 - 1967 .
Levi M, Sivapalaratnam S ( 2020 ) . An overview of thrombotic complications of old and new anticancer drugs . Thrombosis Research vol. 191 , s17 - s21 .
Bowles L, Platton S, Yartey N, Dave M, Lee K, Hart DP, MacDonald V, Green L et al. ( 2020 ) . Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19 . The New England Journal of Medicine vol. 383 , ( 3 ) 288 - 290 .
Chan MV, Hayman MA, Sivapalaratnam S, Crescente M, Allan HE, Edin ML, Zeldin DC, Milne GL et al. ( 2020 ) . Identification of a homozygous recessive variant in <i>PTGS1</i> resulting in a congenital aspirin-like defect in platelet function . Haematologica vol. 106 , ( 5 ) 1423 - 1432 .
Downes K, Megy K, Duarte D, Vries M, Gebhart J, Hofer S, Shamardina O, Deevi SVV et al. ( 2019 ) . Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders . Blood vol. 134 , ( 23 ) 2082 - 2091 .
Lentaigne C, Greene D, Sivapalaratnam S, Favier R, Seyres D, Thys C, Grassi L, Mangles S et al. ( 2019 ) . Germline mutations in the transcription factor IKZF5 cause thrombocytopenia . Blood vol. 134 , ( 23 ) 2070 - 2081 .
Akay M, Vaidya S, Sivapalaratnam S, Theodoulou A, Hart D ( 2019 ) . A novel variant causing α2 antiplasmin deficiency: case report and experience in a UK centre . British Journal of Haematology vol. 187 , ( 2 ) e42 - e44 .
Sivapalaratnam S, Linpower L, Sirigireddy B, Agapidou A, Jain S, Win N, Tsitsikas DA ( 2019 ) . Treatment of post‐transfusion hyperhaemolysis syndrome in Sickle Cell Disease with the anti‐IL6R humanised monoclonal antibody Tocilizumab . British Journal of Haematology vol. 186 , ( 6 ) e212 - e214 .
Levi M, Sivapalaratnam S ( 2019 ) . Coagulation and anticoagulation in the intraoperative setting . Transfusion and Apheresis Science vol. 58 , ( 4 ) 386 - 391 .
Justice AE, Karaderi T, Highland HM, Young KL, Graff M, Lu Y, Turcot V, Auer PL et al. ( 2019 ) . Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution . Nature Genetics vol. 51 , ( 3 ) 452 - 469 .
Sivapalaratnam S ( 2019 ) . Artificial intelligence and machine learning in haematology . British Journal of Haematology vol. 185 , ( 2 ) 207 - 208 .
van Geffen JP, Brouns SLN, Batista J, McKinney H, Kempster C, Nagy M, Sivapalaratnam S, Baaten CCFMJ et al. ( 2018 ) . High-throughput elucidation of thrombus formation reveals sources of platelet function variability . Haematologica vol. 104 , ( 6 ) 1256 - 1267 .
Levi M, Sivapalaratnam S ( 2018 ) . Disseminated intravascular coagulation: an update on pathogenesis and diagnosis . Expert Review of Hematology vol. 11 , ( 8 ) 663 - 672 .
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T et al. ( 2018 ) . Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity . Nature Genetics vol. 50 , ( 5 ) 766 - 767 .
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T et al. ( 2017 ) . Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity . Nature Genetics vol. 50 , ( 1 ) 26 - 41 .
Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C et al. ( 2017 ) . Exome-wide association study of plasma lipids in >300,000 individuals . Nature Genetics vol. 49 , ( 12 ) 1758 - 1766 .
Holzinger ER, Verma SS, Moore CB, Hall M, De R, Gilbert-Diamond D, Lanktree MB, Pankratz N et al. ( 2017 ) . Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals . BioData Mining vol. 10 , ( 1 )
Sivapalaratnam S, Collins J, Gomez K ( 2017 ) . Diagnosis of inherited bleeding disorders in the genomic era . British Journal of Haematology vol. 179 , ( 3 ) 363 - 376 .
Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, Fine RS, Lu Y et al. ( 2017 ) . Rare and low-frequency coding variants alter human adult height . Nature vol. 542 , ( 7640 ) 186 - 190 .
Sivapalaratnam S, Westbury SK, Stephens JC, Greene D, Downes K, Kelly AM, Lentaigne C, Astle WJ et al. ( 2016 ) . Rare variants in GP1BB are responsible for autosomal dominant macrothrombocytopenia . Blood vol. 129 , ( 4 ) 520 - 524 .
Astle WJ, Elding H, Jiang T, Allen D, Ruklisa D, Mann AL, Mead D, Bouman H et al. ( 2016 ) . The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease . Cell vol. 167 , ( 5 ) 1415 - 1429.e19 .
van Iperen EPA, Sivapalaratnam S, Holmes MV, Hovingh GK, Zwinderman AH, Asselbergs FW ( 2016 ) . Genetic analysis of emerging risk factors in coronary artery disease . Atherosclerosis vol. 254 , 35 - 41 .
Simeoni I, Stephens JC, Hu F, Deevi SVV, Megy K, Bariana TK, Schulman S, Sivapalaratnam S et al. ( 2016 ) . A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders . Blood vol. 127 , ( 23 ) 2791 - 2803 .
Leusink M, der Zee AHM-V, Ding B, Drenos F, van Iperen EP, Warren HR, Caulfield MJ, Cupples LA et al. ( 2016 ) . A genetic risk score is associated with statin-induced low-density lipoprotein cholesterol lowering . Pharmacogenomics vol. 17 , ( 6 ) 583 - 591 .
Nüesch E, Dale C, Palmer TM, White J, Keating BJ, van Iperen EP, Goel A, Padmanabhan S et al. ( 2015 ) . Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis . International Journal of Epidemiology vol. 45 , ( 6 ) 1927 - 1937 .
Maiwald S, Motazacker MM, van Capelleveen JC, Sivapalaratnam S, van der Wal AC, van der Loos C, Kastelein JJP, Ouwehand WH et al. ( 2015 ) . A rare variant in MCF2L identified using exclusion linkage in a pedigree with premature atherosclerosis . European Journal of Human Genetics vol. 24 , ( 1 ) 86 - 91 .
Levi M, Sivapalaratnam S ( 2014 ) . Hemostatic abnormalities in critically ill patients . Internal and Emergency Medicine vol. 10 , ( 3 ) 287 - 296 .
Do R, Stitziel NO, Won H-H, Jørgensen AB, Duga S, Angelica Merlini P, Kiezun A, Farrall M et al. ( 2014 ) . Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction . Nature vol. 518 , ( 7537 ) 102 - 106 .
Maiwald S, Sivapalaratnam S, Motazacker MM, van Capelleveen JC, Bot I, de Jager SC, van Eck M, Jolley J et al. ( 2014 ) . Mutation in KERA Identified by Linkage Analysis and Targeted Resequencing in a Pedigree with Premature Atherosclerosis . PLOS ONE vol. 9 , ( 5 )
Maiwald S, Oey RC, Sivapalaratnam S, Bakhtiari K, Hovingh GK, Basart DCG, Trip MD, Dallinga-Thie GM ( 2014 ) . Abnormal hemostatic parameters in patients with myocardial infarction but angiographically normal coronary arteries . International Journal of Cardiology vol. 174 , ( 3 ) 734 - 735 .
Mahajan A, Go MJ, Zhang W, Below JE, Gaulton KJ, Ferreira T, Horikoshi M, Johnson AD et al. ( 2014 ) . Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility . Nature Genetics vol. 46 , ( 3 ) 234 - 244 .
Holmes MV, Asselbergs FW, Palmer TM, Drenos F, Lanktree MB, Nelson CP, Dale CE, Padmanabhan S et al. ( 2014 ) . Mendelian randomization of blood lipids for coronary heart disease . European Heart Journal vol. 36 , ( 9 ) 539 - 550 .
van Iperen EPA, Sivapalaratnam S, Boekholdt SM, Hovingh GK, Maiwald S, Tanck MW, Soranzo N, Stephens JC et al. ( 2013 ) . Common genetic variants do not associate with CAD in familial hypercholesterolemia . European Journal of Human Genetics vol. 22 , ( 6 ) 809 - 813 .
Stitziel NO, Fouchier SW, Sjouke B, Peloso GM, Moscoso AM, Auer PL, Goel A, Gigante B et al. ( 2013 ) . Exome Sequencing and Directed Clinical Phenotyping Diagnose Cholesterol Ester Storage Disease Presenting as Autosomal Recessive Hypercholesterolemia . Arteriosclerosis Thrombosis and Vascular Biology vol. 33 , ( 12 ) 2909 - 2914 .
Maiwald S, Zwetsloot P-P, Sivapalaratnam S, Dallinga-Thie GM ( 2013 ) . Monocyte gene expression and coronary artery disease . Current Opinion in Clinical Nutrition & Metabolic Care vol. 16 , ( 4 ) 411 - 417 .
Singaraja RR, Sivapalaratnam S, Hovingh K, Dubé M-P, Castro-Perez J, Collins HL, Adelman SJ, Riwanto M et al. ( 2012 ) . The Impact of Partial and Complete Loss-of-Function Mutations in Endothelial Lipase on High-Density Lipoprotein Levels and Functionality in Humans . Circulation Genomic and Precision Medicine vol. 6 , ( 1 ) 54 - 62 .
Elbers CC, Guo Y, Tragante V, van Iperen EPA, Lanktree MB, Castillo BA, Chen F, Yanek LR et al. ( 2012 ) . Gene-Centric Meta-Analysis of Lipid Traits in African, East Asian and Hispanic Populations . PLOS ONE vol. 7 , ( 12 )
Asselbergs FW, Guo Y, van Iperen EPA, Sivapalaratnam S, Tragante V, Lanktree MB, Lange LA, Almoguera B et al. ( 2012 ) . Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci . American Journal of Human Genetics vol. 91 , ( 5 ) 823 - 838 .
Oosterveer DM, Versmissen J, Defesche JC, Sivapalaratnam S, Yazdanpanah M, Mulder M, van der Zee L, Uitterlinden AG et al. ( 2012 ) . Low-density lipoprotein receptor mutations generate synthetic genome-wide associations . European Journal of Human Genetics vol. 21 , ( 5 ) 563 - 566 .
Morris AP, Voight BF, Teslovich TM, Ferreira T, Segré AV, Steinthorsdottir V, Strawbridge RJ, Khan H et al. ( 2012 ) . Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes . Nature Genetics vol. 44 , ( 9 ) 981 - 990 .
Mulders TA, Sivapalaratnam S, Stroes ESG, Kastelein JJP, Guerci AD, Pinto-Sietsma S-J ( 2012 ) . Asymptomatic Individuals With a Positive Family History for Premature Coronary Artery Disease and Elevated Coronary Calcium Scores Benefit From Statin Treatment A Post Hoc Analysis From the St. Francis Heart Study . JACC Cardiovascular Imaging vol. 5 , ( 3 ) 252 - 260 .
Sivapalaratnam S, Basart H, Watkins NA, Maiwald S, Rendon A, Krishnan U, Sondermeijer BM, Creemers EE et al. ( 2012 ) . Monocyte Gene Expression Signature of Patients with Early Onset Coronary Artery Disease . PLOS ONE vol. 7 , ( 2 )
Sondermeijer BM, Bakker A, Halliani A, de Ronde MWJ, Marquart AA, Tijsen AJ, Mulders TA, Kok MGM et al. ( 2011 ) . Platelets in Patients with Premature Coronary Artery Disease Exhibit Upregulation of miRNA340* and miRNA624* . PLOS ONE vol. 6 , ( 10 )
Sivapalaratnam S, Farrugia R, Nieuwdorp M, Langford CF, van Beem RT, Maiwald S, Zwaginga JJ, Gusnanto A et al. ( 2011 ) . Identification of candidate genes linking systemic inflammation to atherosclerosis; results of a human in vivoLPS infusion study . BMC Medical Genomics vol. 4 , ( 1 )
Albers CA, Cvejic A, Favier R, Bouwmans EE, Alessi M-C, Bertone P, Jordan G, Kettleborough RNW et al. ( 2011 ) . Exome sequencing identifies NBEAL2 as the causative gene for gray platelet syndrome . Nature Genetics vol. 43 , ( 8 ) 735 - 737 .
Paul DS, Nisbet JP, Yang T-P, Meacham S, Rendon A, Tallila J, White J, Tijssen MR et al. ( 2011 ) . Maps of Open Chromatin Guide the Functional Follow-Up of Genome-Wide Association Signals: Application to Hematological Traits . PLOS Genetics vol. 7 , ( 6 )
Schunkert H, König IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AFR et al. ( 2011 ) . Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease . Nature Genetics vol. 43 , ( 4 ) 333 - 338 .
Sivapalaratnam S, Motazacker MM, Maiwald S, Hovingh GK, Kastelein JJP, Levi M, Trip MD, Dallinga-Thie GM ( 2011 ) . Genome-Wide Association Studies in Atherosclerosis . Current Atherosclerosis Reports vol. 13 , ( 3 ) 225 - 232 .
Sivapalaratnam S, Boekholdt SM, Trip MD, Sandhu MS, Luben R, Kastelein JJP, Wareham NJ, Khaw K-T ( 2010 ) . Family history of premature coronary heart disease and risk prediction in the EPIC-Norfolk prospective population study . Heart vol. 96 , ( 24 )
van der Graaf A, Vissers MN, Gaudet D, Brisson D, Sivapalaratnam S, Roseboom TJ, Jansen ACM, Kastelein JJP et al. ( 2010 ) . Dyslipidemia of Mothers With Familial Hypercholesterolemia Deteriorates Lipids in Adult Offspring . Arteriosclerosis Thrombosis and Vascular Biology vol. 30 , ( 12 ) 2673 - 2677 .
Aalbers CJ, Groen JL, Sivapalaratnam S ( 2010 ) . More outreach for young scientists . Nature vol. 467 , ( 7314 ) 401 - 401 .
Sivapalaratnam S, van Loendersloot LL, Hutten BA, Kastelein JJP, Trip MD, de Groot E ( 2010 ) . Long-term LDL-c lowering in heterozygous familial hypercholesterolemia normalizes carotid intima-media thickness . Atherosclerosis vol. 212 , ( 2 ) 571 - 574 .
Kreuter D, Taylor J, Deltadahl S, Besser M, Bradley JR, Gilbey J, Kaptoge S, Kingston N et al. . Artificial Intelligence for Pre-Anaemic Iron Deficiency Detection Using Rich Complete Blood Count Data .
Downes K, Megy K, Duarte D, Vries M, Gebhart J, Hofer S, Shamardina O, Deevi SV et al. . Diagnostic high-throughput sequencing of 2,390 patients with bleeding, thrombotic and platelet disorders .
Back to Search