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  1. Queen Mary University of London
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Publications: DR Diego Villar Lozano

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Rodriguez A, Frost S, Thomas AM, Fernandez-Aroca D, Choudhury J, Tikkas G, Tinker A, Munroe PB et al. ( 2026 ) . An epigenomic investigation of atrial fibrillation in a matched left and right atrial human cohort . Clinical Epigenetics vol. 18 , ( 1 )
Rimoldi M, Wang N, Zhang J, Villar D, Odom DT, Taipale J, Flicek P, Roller M ( 2024 ) . DNA methylation patterns of transcription factor binding regions characterize their functional and evolutionary contexts . Genome Biology vol. 25 , ( 1 )
Lu AT, Fei Z, Haghani A, Robeck TR, Zoller JA, Li CZ, Lowe R, Yan Q et al. ( 2023 ) . Author Correction: Universal DNA methylation age across mammalian tissues . Nature Aging vol. 3 , ( 11 ) 1462 - 1462 .
Parey E, Fernandez-Aroca D, Frost S, Uribarren A, Park TJ, Zöttl M, St John Smith E, Berthelot C et al. ( 2023 ) . Phylogenetic modeling of enhancer shifts in African mole-rats reveals regulatory changes associated with tissue-specific traits . Genome Research vol. 33 , ( 9 ) 1513 - 1526 .
Haghani A, Li CZ, Robeck TR, Zhang J, Lu AT, Ablaeva J, Acosta-Rodríguez VA, Adams DM et al. ( 2023 ) . DNA methylation networks underlying mammalian traits . Science vol. 381 , ( 6658 ) eabq5693 - eabq5693 .
Lu AT, Fei Z, Haghani A, Robeck TR, Zoller JA, Li CZ, Lowe R, Yan Q et al. ( 2023 ) . Universal DNA methylation age across mammalian tissues . Nature Aging vol. 3 , ( 9 ) 1144 - 1166 .
Frost S, Parey E, Tinker A, Villar D ( 2023 ) . BS47 A comparative genomics approach reveals the interplay between epigenomic enhancer conservation and common genetic variation in the heart . Conference: Basic Sciencea279.2 - a2a279 .
Rodriguez A, Villar D, Frost S, Tinker A, Thomas A ( 2023 ) . BS56 An epigenomic investigation of atrial fibrillation in a paired left and right atrial cohort . Conference: Basic Sciencea285.1 - a2a285 .
Fernández-Aroca D, Frost S, Tikkas G, Rodriguez A, Tinker A, Villar D ( 2023 ) . BS69 Characterisation of in vivo and in vitro models for epigenomic investigations of cardiac hypertrophy . Conference: Basic Sciencea296.1 - a2a296 .
Villar D ( 2023 ) . BS76 A phylogenetic modelling approach to identify evolutionary shifts in tissue-specific enhancers - application to the mole-rat clade . Conference: Basic Sciencea301 - a301 .
Fernández-Aroca DM, García-Flores N, Frost S, Jiménez-Suárez J, Rodríguez-González A, Fernández-Aroca P, Sabater S, Andrés I et al. ( 2023 ) . MAPK11 (p38β) is a major determinant of cellular radiosensitivity by controlling ionizing radiation-associated senescence: An in vitro study . Clinical and Translational Radiation Oncology vol. 41 ,
Roller M, Stamper E, Villar D, Izuogu O, Martin F, Redmond AM, Ramachanderan R, Harewood L et al. ( 2021 ) . LINE retrotransposons characterize mammalian tissue-specific and evolutionarily dynamic regulatory regions . Genome Biology vol. 22 , ( 1 )
Villar D, Frost S, Deloukas P, Tinker A ( 2020 ) . The contribution of non-coding regulatory elements to cardiovascular disease . Open Biology vol. 10 , ( 7 )
Berthelot C, Villar D, Odom DT, Flicek P ( 2019 ) . The gene expression consequences of mammalian regulatory evolution . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 27 , 767 - 767 .
Berthelot C, Villar D, Horvath JE, Odom DT, Flicek P ( 2017 ) . Complexity and conservation of regulatory landscapes underlie evolutionary resilience of mammalian gene expression . Nature Ecology & Evolution vol. 2 , ( 1 ) 152 - 163 .
Jasinska AJ, Zelaya I, Service SK, Peterson CB, Cantor RM, Choi O-W, DeYoung J, Eskin E et al. ( 2017 ) . Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate . Nature Genetics vol. 49 , ( 12 ) 1714 - 1721 .
Villar D, Odom DT ( 2016 ) . Unwinding Limb Development . Cell vol. 167 , ( 3 ) 598 - 600 .
Rensch T, Villar D, Horvath J, Odom DT, Flicek P ( 2016 ) . Mitochondrial heteroplasmy in vertebrates using ChIP-sequencing data . Genome Biology vol. 17 , ( 1 )
Rudolph KLM, Schmitt BM, Villar D, White RJ, Marioni JC, Kutter C, Odom DT ( 2016 ) . Codon-Driven Translational Efficiency Is Stable across Diverse Mammalian Cell States . PLOS Genetics vol. 12 , ( 5 )
Naranjo JR, Zhang H, Villar D, González P, Dopazo XM, Morón-Oset J, Higueras E, Oliveros JC et al. ( 2016 ) . Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease . Journal of Clinical Investigation vol. 126 , ( 2 ) 627 - 638 .
Villar D, Odom DT ( 2015 ) . When the Snake Lost Its Limbs, What Did the Mouse and Lizard Say? . Developmental Cell vol. 35 , ( 1 ) 3 - 4 .
Villar D, Berthelot C, Aldridge S, Rayner TF, Lukk M, Pignatelli M, Park TJ, Deaville R et al. ( 2015 ) . Enhancer Evolution across 20 Mammalian Species . Cell vol. 160 , ( 3 ) 554 - 566 .
Villar D, Flicek P, Odom DT ( 2014 ) . Evolution of transcription factor binding in metazoans — mechanisms and functional implications . Nature Reviews Genetics vol. 15 , ( 4 ) 221 - 233 .
Gonzalez-Flores A, Aguilar-Quesada R, Siles E, Pozo S, Rodríguez-Lara MI, López –Jiménez L, López-Rodríguez M, Peralta-Leal A et al. ( 2013 ) . Interaction between PARP-1 and HIF-2α in the hypoxic response . Oncogene vol. 33 , ( 7 ) 891 - 898 .
Villar D, Ortiz-Barahona A, Gómez-Maldonado L, Pescador N, Sánchez-Cabo F, Hackl H, Rodriguez BAT, Trajanoski Z et al. ( 2012 ) . Cooperativity of Stress-Responsive Transcription Factors in Core Hypoxia-Inducible Factor Binding Regions . PLOS ONE vol. 7 , ( 9 )
Villar D, Odom DT ( 2012 ) . Generalizing complexity: a fruitful partnership of functional genomics and systems biology . Genome Medicine vol. 4 , ( 2 )
Tiana M, Villar D, Pérez-Guijarro E, Gómez-Maldonado L, Moltó E, Fernández-Miñán A, Gómez-Skarmeta JL, Montoliu L et al. ( 2011 ) . A role for insulator elements in the regulation of gene expression response to hypoxia . Nucleic Acids Research vol. 40 , ( 5 ) 1916 - 1927 .
Rivas M, Villar D, González P, Dopazo XM, Mellstrom B, Naranjo JR ( 2011 ) . Building the DREAM interactome . Science China Life Sciences vol. 54 , ( 8 ) 786 - 792 .
Pescador N, Villar D, Cifuentes D, Garcia-Rocha M, Ortiz-Barahona A, Vazquez S, Ordoñez A, Cuevas Y et al. ( 2010 ) . Hypoxia Promotes Glycogen Accumulation through Hypoxia Inducible Factor (HIF)-Mediated Induction of Glycogen Synthase 1 . PLOS ONE vol. 5 , ( 3 )
Ortiz-Barahona A, Villar D, Pescador N, Amigo J, del Peso L ( 2010 ) . Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction . Nucleic Acids Research vol. 38 , ( 7 ) 2332 - 2345 .
Villar D, Vara-Vega A, Landázuri MO, Del Peso L ( 2007 ) . Identification of a region on hypoxia-inducible-factor prolyl 4-hydroxylases that determines their specificity for the oxygen degradation domains . Biochemical Journal vol. 408 , ( 2 ) 231 - 240 .
Pescador N, Cuevas Y, Naranjo S, Alcaide M, Villar D, Landázuri MO, del Peso L ( 2005 ) . Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene . Biochemical Journal vol. 390 , ( 1 ) 189 - 197 .
Rodriguez A, Frost S, Thomas AM, Fernandez-Aroca D, Choudhury J, Tikkas G, Tinker A, Munroe PB et al. . An epigenomic investigation of atrial fibrillation in a matched left and right atrial human cohort .
Berthelot C, Villar D, Horvath JE, Odom DT, Flicek P . Complexity and conservation of regulatory landscapes underlie evolutionary resilience of mammalian gene expression .
Daunesse M, Liorzou E, Parey E, Villar D, Berthelot C . Coordinated shifts in gene expression and regulation during mole-rat evolution .
Haghani A, Lu AT, Li CZ, Robeck TR, Belov K, Breeze CE, Brooke RT, Clarke S et al. . DNA Methylation Networks Underlying Mammalian Traits .
Rimoldi M, Wang N, Zhang J, Villar D, Odom DT, Taipale J, Flicek P, Roller M . DNA methylation patterns of transcription factor binding regions characterize their functional and evolutionary contexts .
Li CZ, Haghani A, Robeck TR, Villar D, Lu AT, Zhang J, Faulkes CG, Vu H et al. . Epigenetic predictors of maximum lifespan and other life history traits in mammals .
Jasinska AJ, Zelaya I, Service SK, Peterson CB, Cantor RM, Choi O-W, DeYoung J, Eskin E et al. . Genetic variation and gene expression across multiple tissues and developmental stages in a non-human primate .
Roller M, Stamper E, Villar D, Izuogu O, Martin F, Redmond A, Ramachanderan R, Harewood L et al. . LINE elements are a reservoir of regulatory potential in mammalian genomes .
Fernández-Aroca D, García-Flores N, Frost S, Jiménez-Suarez J, Rodríguez-González A, Fernández-Aroca P, Sabater S, Andrés I et al. . MAPK11 (p38β) is a major determinant of cellular radiosensitivity by enhancing IR-associated senescence .
Frost S, Fernandez-Aroca D, Parey E, Rodriguez-Gonzalez A, Pavon-Heredia D, Villar D . Mammalian epigenomic conservation of promoters and enhancers in the heart associates with trait-associated variation and impacts cardiomyocyte phenotypes .
Parey E, Frost S, Uribarren A, Park TJ, Zoettl M, St. John Smith E, Berthelot C, Villar D . Phylogenetic modeling of enhancer shifts in African mole-rats reveals regulatory changes associated with tissue-specific traits .
Lu AT, Fei Z, Haghani A, Robeck TR, Zoller JA, Li CZ, Lowe R, Yan Q et al. . Universal DNA methylation age across mammalian tissues .
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