Publications: DR Jianmin Chen

Margraf A, Chen J, Christoforou M, Claria-Ribas P, Henriques Schneider A, Cecconello C, Bu W, Imbert PRC et al. ( 2025 ) . Formyl-peptide receptor type 2 activation mitigates heart and lung damage in inflammatory arthritis . EMBO Molecular Medicine vol. 17 , ( 5 ) 1153 - 1183 .

Peh HY, Chen J ( 2025 ) . Pro-resolving lipid mediators and therapeutic innovations in resolution of inflammation . Pharmacology & Therapeutics vol. 265 , Article 108753 , 108753 - 108753 .

Suffee N, Le Goff W, Chen J ( 2024 ) . Editorial: Cardiometabolic diseases and inflammatory responses . Frontiers in Immunology vol. 15 , Article 1384022 ,

Chen J, Oggero S, Cecconello C, Dalli J, Hayat H, Hjiej Andaloussi A, Sanni S, Jonassen TEN et al. ( 2023 ) . The Annexin-A1 mimetic RTP-026 promotes acute cardioprotection through modulation of immune cell activation . Pharmacological Research vol. 198 , Article 107005 , 107005 - 107005 .

Chen J, Austin-Williams S, O'Riordan CE, Claria-Ribas P, Sugimoto MA, Norling LV, Thiemermann C, Perretti M ( 2023 ) . Formyl Peptide Receptor Type 2 Deficiency in Myeloid Cells Amplifies Sepsis-Induced Cardiac Dysfunction . Journal of Innate Immunity vol. 15 , ( 1 ) 548 - 561 .

Costa VV, Sugimoto MA, Hubner J, Bonilha CS, Queiroz-Junior CM, Gonçalves-Pereira MH, Chen J, Gobbetti T et al. ( 2022 ) . Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue disease . eLife vol. 11 , Article e73853 ,

Hamers A, Primus CP, Whitear C, Kumar NA, Masucci M, Montalvo Moreira SA, Rathod K, Chen J et al. ( 2022 ) . 20‐hydroxyeicosatetraenoic acid (20‐HETE) is a pivotal endogenous ligand for TRPV1‐mediated neurogenic inflammation in the skin . British Journal of Pharmacology vol. 179 , ( 7 ) 1450 - 1469 .

Gee LC, Massimo G, Lau C, Primus C, Fernandes D, Chen J, Rathod KS, Hamers AJP et al. ( 2021 ) . Inorganic nitrate attenuates cardiac dysfunction: roles for xanthine oxidoreductase and nitric oxide . British Journal of Pharmacology vol. 179 , ( 20 ) 4757 - 4777 .

Chen J, Norling LV, Garrido Mesa J, Silva MDP, Burton SE, Reutelingsperger C, Perretti M, Cooper D ( 2021 ) . Annexin A1 attenuates cardiac diastolic dysfunction in mice with inflammatory arthritis . Proceedings of the National Academy of Sciences vol. 118 , ( 38 ) Article e2020385118 ,

de Gaetano M, Tighe C, Gahan K, Zanetti A, Chen J, Newson J, Cacace A, Marai M et al. ( 2021 ) . Asymmetric Synthesis and Biological Screening of Quinoxaline-Containing Synthetic Lipoxin A₄ Mimetics (QNX-sLXms) . Journal of Medicinal Chemistry vol. 64 , ( 13 ) 9193 - 9216 .

Chen J, Purvis GSD, Collotta D, Al Zoubi S, Sugimoto MA, Cacace A, Martin L, Colas RA et al. ( 2020 ) . RvE1 Attenuates Polymicrobial Sepsis-Induced Cardiac Dysfunction and Enhances Bacterial Clearance . Frontiers in Immunology vol. 11 , Article 2080 ,

Aziz Q, Chen J, Moyes AJ, Li Y, Anderson NA, Ang R, Aksentijevic D, Sebastian S et al. ( 2020 ) . Vascular KATP channels protect from cardiac dysfunction and preserve cardiac metabolism during endotoxemia . Journal of Molecular Medicine vol. 98 , ( 8 ) 1149 - 1160 .

Kieswich J, Chen J, Alliouachene S, Caton P, McCafferty K, Thiemermann C, Yaqoob M ( 2020 ) . Immunohistochemistry of Kidney a-SMA, Collagen 1, and Collagen 3, in A Novel Mouse Model of Reno-cardiac Syndrome . BIO-PROTOCOL vol. 10 , ( 18 )

Yun Y, Chen J, Liu R, Chen W, Liu C, Wang R, Hou Z, Yu Z et al. ( 2019 ) . Long residence time adenosine A1 receptor agonists produce sustained wash-resistant antilipolytic effect in rat adipocytes . Biochemical Pharmacology vol. 164 , 45 - 52 .

de Gaetano M, Butler E, Gahan K, Zanetti A, Marai M, Chen J, Cacace A, Hams E et al. ( 2019 ) . Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms) . European Journal of Medicinal Chemistry vol. 162 , 80 - 108 .

Al Zoubi S, Chen J, Murphy C, Martin L, Chiazza F, Collotta D, Yaqoob MM, Collino M et al. ( 2018 ) . Linagliptin Attenuates the Cardiac Dysfunction Associated With Experimental Sepsis in Mice With Pre-existing Type 2 Diabetes by Inhibiting NF-κB . Frontiers in Immunology vol. 9 , Article 2996 ,

Kieswich JE, Chen J, Alliouachene S, Caton PW, McCafferty K, Thiemermann C, Yaqoob MM ( 2018 ) . A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain . BMC Nephrology vol. 19 , ( 1 ) Article 346 ,

Khan AI, Kapoor A, Chen J, Martin L, Rogazzo M, Mercier T, Decosterd L, Collino M et al. ( 2018 ) . The Antimalarial Drug Artesunate Attenuates Cardiac Injury in A Rodent Model of Myocardial Infarction . Shock (Augusta, Ga.) vol. 49 , ( 6 ) 675 - 681 .

Chen J, Hamers AJP, Finsterbusch M, Massimo G, Zafar M, Corder R, Colas RA, Dalli J et al. ( 2018 ) . Endogenously generated arachidonate‐derived ligands for TRPV1 induce cardiac protection in sepsis . The FASEB Journal vol. 32 , ( 7 ) 3816 - 3831 .

Purvis GSD, Chiazza F, Chen J, Azevedo-Loiola R, Martin L, Kusters DHM, Reutelingsperger C, Fountoulakis N et al. ( 2017 ) . RETRACTED ARTICLE: Annexin A1 attenuates microvascular complications through restoration of Akt signalling in a murine model of type 1 diabetes . Diabetologia vol. 61 , ( 2 ) 482 - 495 .

Johnson FL, Patel NSA, Purvis GSD, Chiazza F, Chen J, Sordi R, Hache G, Merezhko VV et al. ( 2017 ) . Inhibition of IκB Kinase at 24 Hours After Acute Kidney Injury Improves Recovery of Renal Function and Attenuates Fibrosis . Journal of the American Heart Association vol. 6 , ( 7 ) Article e005092 ,

Martin L, Gombert A, Chen J, Liebens J, Verleger J, Kalder J, Marx G, Jacobs M et al. ( 2017 ) . The β-d-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men . Frontiers in Immunology vol. 8 , Article 681 ,

Martin L, Chen J, Zechendorf E, Chiazza F, Oggero S, Collino M, Marx G, Schuerholz T et al. ( 2017 ) . ROLE OF THE β-D-ENDOGLUCURONIDASE HEPARANASE IN SEPTIC CARDIOMYOPATHY . SHOCK . vol. 47 , 129 - 129 .

Chen J, Thiemermann C ( 2016 ) . Selenium and Niacin for Sepsis Therapy: The Sum Is Greater Than Its Parts* . Critical Care Medicine vol. 44 , ( 6 ) 1256 - 1257 .

Chen J, Kieswich JE, Chiazza F, Moyes AJ, Gobbetti T, Purvis GSD, Salvatori DCF, Patel NSA et al. ( 2016 ) . IκB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD . Journal of the American Society of Nephrology vol. 28 , ( 1 ) 94 - 105 .

Chen J, Hamers AJP, Finsterbusch M, Thiemermann C, Ahluwalia A ( 2016 ) . Activation of TRPV1 by 12(s)‐HpETE and 20‐HETE Releases CGRP and Protects the Heart Against the Cardiac Dysfunction Caused by LPS . The FASEB Journal . vol. 30 ,

Chen J, Hamers AJP, Finsterbusch M, Thiemermann C, Ahluwalia A ( 2016 ) . ACTIVATION OF TRPV1 BY 12(S)-HPETE AND 20-HETE RELEASES CGRP AND PROTECTS THE HEART AGAINST THE CARDIAC DYSFUNCTION CAUSED BY LPS . SHOCK . vol. 46 , 31 - 32 .

Martin LB, Zechendorf E, Chen J, Brandenburg K, Marx G, Thiemermann C, Schuerholz T ( 2016 ) . THE SYNTHETIC ANTIMICROBIAL PEPTIDE 19-2.5 ATTENUATES SEPTIC CARDIOMYOPATHY IN A MURINE MODEL OF POLYMICROBIAL SEPSIS . SHOCK . vol. 46 , 31 - 31 .

Zhang W, Zhao X, Xiao Y, Chen J, Han P, Zhang J, Fu H, James Kang Y ( 2016 ) . The association of depressed angiogenic factors with reduced capillary density in the Rhesus monkey model of myocardial ischemia . Metallomics vol. 8 , ( 7 ) 654 - 662 .

Chen J, Kieswich J, Chiazza F, Gobbetti T, Patel NS, Perretti M, Collino M, Yaqoob MM et al. ( 2015 ) . THE CARDIAC DYSFUNCTION CAUSED BY SEPSIS IN ANIMALS WITH CHRONIC KIDNEY DISEASE IS ATTENUATED BY INHIBITING IκB KINASE . SHOCK . vol. 43 , 92 - 93 .

Gobbetti T, Coldewey SM, Chen J, McArthur S, le Faouder P, Cenac N, Flower RJ, Thiemermann C et al. ( 2014 ) . Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis . Proceedings of the National Academy of Sciences vol. 111 , ( 52 ) 18685 - 18690 .

Chen J, Chiazza F, Collino M, Patel NSA, Coldewey SM, Thiemermann C ( 2014 ) . Gender Dimorphism of the Cardiac Dysfunction in Murine Sepsis: Signalling Mechanisms and Age-Dependency . PLoS ONE vol. 9 , ( 6 ) e100631 - e100631 .

Chen J, Chiazza F, Collino M, Coldewey SM, Patel NS, Thiemermann C ( 2014 ) . GENDER DIMORPHISM OF THE CARDIAC DYSFUNCTION IN SEPSIS . SHOCK . vol. 41 , 35 - 35 .

Chen J, Kieswich J, Yaqoob MM, Thiemermann C ( 2014 ) . PRE-EXISTING CHRONIC KIDNEY DISEASE WORSENS MYOCARDIAL DYSFUNCTION CAUSED BY SEPSIS IN MICE . SHOCK . vol. 41 , 40 - 41 .

Sun X, Cai J, Fan X, Han P, Xie Y, Chen J, Xiao Y, Kang YJ ( 2013 ) . Decreases in Electrocardiographic R-Wave Amplitude and QT Interval Predict Myocardial Ischemic Infarction in Rhesus Monkeys with Left Anterior Descending Artery Ligation . PLoS ONE vol. 8 , ( 8 ) e71876 - e71876 .

Hafner S, Wepler M, McCook O, Scheuerle A, Wagner F, Matallo J, Chen J, Calzia E et al. ( 2013 ) . EFFECTS OF THE PPAR-β/δ AGONIST GW0742 ON RENAL INFLAMMATION AND KIDNEY TISSUE INJURY DURING RESUSCITATED PORCINE SEPTIC SHOCK . SHOCK . vol. 40 , 24 - 24 .

Xie Y, Chen J, Han P, Yang P, Hou J, Kang YJ ( 2012 ) . Immunohistochemical detection of differentially localized up-regulation of lysyl oxidase and down-regulation of matrix metalloproteinase-1 in rhesus monkey model of chronic myocardial infarction . Experimental Biology and Medicine vol. 237 , ( 7 ) 853 - 859 .