Publications: DR Vidya Darbari

Liang R, Torres-Flores AP, Qi S, Khursheed A, Tian Y, Szwedziak P, Baker MD, Volkov VA et al. ( 2024 ) . Structural architecture of amyloid-β oligomers, curvilinear protofibrils and annular assemblies, imaged by cryo-EM and cryo-ET .

Corsini P, Wang S, Rehman S, Fenn K, Sagar A, Sirovica S, Cleaver L, Edwards-Gayle C et al. ( 2022 ) . Molecular and cellular insight into Escherichia coli SslE and its role during biofilm maturation . Access Microbiology vol. 4 , ( 5 )

Corsini PM, Wang S, Rehman S, Fenn K, Sagar A, Sirovica S, Cleaver L, Edwards-Gayle CJC et al. ( 2022 ) . Molecular and cellular insight into Escherichia coli SslE and its role during biofilm maturation . npj Biofilms and Microbiomes vol. 8 , ( 1 ) Article 9 ,

Corsini PM, Wang S, Rehman S, Fenn K, Sagar A, Sirovica S, Cleaver L, Edwards-Gayle CJC et al. ( 2021 ) . Molecular and cellular insight into <i>Escherichia coli</i> SslE and its role during biofilm maturation .

Darbari VC, Ciccone J, Patel JS, Islam B, Agarwal PK, Haider S ( 2020 ) . Electrostatic Switching Controls Channel Dynamics of the Sensor Protein VirB10 in <i>A. tumefaciens</i> Type IV Secretion System . ACS Omega vol. 5 , ( 7 ) 3271 - 3281 .

Fenn K, Wong CT, Darbari VC ( 2020 ) . Mycobacterium tuberculosis Uses Mce Proteins to Interfere With Host Cell Signaling . Frontiers in Molecular Biosciences vol. 6 , Article 149 ,

Glyde R, Ye F, Darbari VC, Zhang N, Buck M, Zhang X ( 2017 ) . Structures of RNA Polymerase Closed and Intermediate Complexes Reveal Mechanisms of DNA Opening and Transcription Initiation . Molecular Cell vol. 67 , ( 1 ) 106 - 116.e4 .

Zhang N, Darbari VC, Glyde R, Zhang X, Buck M ( 2016 ) . The bacterial enhancer-dependent RNA polymerase . Biochemical Journal vol. 473 , ( 21 ) 3741 - 3753 .

Sawicka M, Wanrooij PH, Darbari VC, Tannous E, Hailemariam S, Bose D, Makarova AV, Burgers PM et al. ( 2016 ) . The Dimeric Architecture of Checkpoint Kinases Mec1ATR and Tel1ATM Reveal a Common Structural Organization . Journal of Biological Chemistry vol. 291 , ( 26 ) 13436 - 13447 .

Yang Y, Darbari VC, Zhang N, Lu D, Glyde R, Wang Y-P, Winkelman JT, Gourse RL et al. ( 2015 ) . Structures of the RNA polymerase-σ\n ⁵⁴\n reveal new and conserved regulatory strategies . Science vol. 349 , ( 6250 ) 882 - 885 .

Chandran Darbari V, Waksman G ( 2015 ) . Structural Biology of Bacterial Type IV Secretion Systems . Annual Reviews

Darbari VC, Lawton E, Lu D, Burrows PC, Wiesler S, Joly N, Zhang N, Zhang X et al. ( 2014 ) . Molecular basis of nucleotide-dependent substrate engagement and remodeling by an AAA+ activator . Nucleic Acids Research vol. 42 , ( 14 ) 9249 - 9261 .

Rivera-Calzada A, Fronzes R, Savva CG, Chandran V, Lian PW, Laeremans T, Pardon E, Steyaert J et al. ( 2013 ) . Structure of a bacterial type IV secretion core complex at subnanometre resolution . The EMBO Journal vol. 32 , ( 8 ) 1195 - 1204 .

Chandran V ( 2013 ) . Type IV secretion machinery: molecular architecture and function . Biochemical Society Transactions vol. 41 , ( 1 ) 17 - 28 .

Banta LM, Kerr JE, Cascales E, Giuliano ME, Bailey ME, McKay C, Chandran V, Waksman G et al. ( 2011 ) . An Agrobacterium VirB10 Mutation Conferring a Type IV Secretion System Gating Defect . Journal of Bacteriology vol. 193 , ( 10 ) 2566 - 2574 .

Nurmohamed S, Vincent HA, Titman CM, Chandran V, Pears MR, Du D, Griffin JL, Callaghan AJ et al. ( 2011 ) . Polynucleotide Phosphorylase Activity May Be Modulated by Metabolites in Escherichia coli . Journal of Biological Chemistry vol. 286 , ( 16 ) 14315 - 14323 .

Rêgo AT, Chandran V, Waksman G ( 2010 ) . Two-step and one-step secretion mechanisms in Gram-negative bacteria: contrasting the type IV secretion system and the chaperone-usher pathway of pilus biogenesis . Biochemical Journal vol. 425 , ( 3 ) 475 - 488 .

Chandran V, Fronzes R, Duquerroy S, Cronin N, Navaza J, Waksman G ( 2009 ) . Structure of the outer membrane complex of a type IV secretion system . Nature vol. 462 , ( 7276 ) 1011 - 1015 .

Durand E, Verger D, Rego A, Chandran V, Meng G, Fronzes R, Waksman G ( 2009 ) . Structural Biology of Bacterial Secretion Systems in Gram-Negative Pathogens- Potential for New Drug Targets . Infectious Disorders - Drug Targets vol. 9 , ( 5 ) 518 - 547 .

Meng G, Fronzes R, Chandran V, Remaut H, Waksman G ( 2009 ) . Protein oligomerization in the bacterial outer membrane (Review) . Molecular Membrane Biology vol. 26 , ( 3 ) 136 - 145 .

Chandran V, Poljak L, Vanzo NF, Leroy A, Miguel RN, Fernandez-Recio J, Parkinson J, Burns C et al. ( 2007 ) . Recognition and Cooperation Between the ATP-dependent RNA Helicase RhlB and Ribonuclease RNase E . Journal of Molecular Biology vol. 367 , ( 1 ) 113 - 132 .

Marcaida MJ, DePristo MA, Chandran V, Carpousis AJ, Luisi BF ( 2006 ) . The RNA degradosome: life in the fast lane of adaptive molecular evolution . Trends in Biochemical Sciences vol. 31 , ( 7 ) 359 - 365 .

Chandran V, Luisi BF ( 2006 ) . Recognition of Enolase in the Escherichia coli RNA Degradosome . Journal of Molecular Biology vol. 358 , ( 1 ) 8 - 15 .

Chandran V, Stollar EJ, Lindorff-Larsen K, Harper JF, Chazin WJ, Dobson CM, Luisi BF, Christodoulou J ( 2006 ) . Structure of the Regulatory Apparatus of a Calcium-dependent Protein Kinase (CDPK): A Novel Mode of Calmodulin-target Recognition . Journal of Molecular Biology vol. 357 , ( 2 ) 400 - 410 .

Chandran V ( 2006 ) . Structural and functional characterisation of the protein-protein and protein-RNA interactions in the RNA degradosome .

Callaghan AJ, Aurikko JP, Ilag LL, Günter Grossmann J, Chandran V, Kühnel K, Poljak L, Carpousis AJ et al. ( 2004 ) . Studies of the RNA Degradosome-organizing Domain of the Escherichia coli Ribonuclease RNase E . Journal of Molecular Biology vol. 340 , ( 5 ) 965 - 979 .

Chandran V, Callaghan A, Long J, Zaid O, Aurikka J, Ilag L, Robinson C, Carpousis AJ et al. ( 2004 ) . Protein-protein interactions in the RNA degradosome . PROTEIN SCIENCE . vol. 13 , 144 - 144 .

Dasgupta S, Chandran V, Bhinge A, Sewlikar S, Nimbkar A, Datta D ( 2004 ) . Role of L-lysine HCl in adoptive immune therapy towards development of suitable tuberculosis vaccination . Indian journal of experimental biology vol. 42 , Article 8 , 758 - 765 .

Dasgupta S, Bhinge A, Chandran V, Sewlikar S, Nimbkar A, Datta D ( 2003 ) . Role of l-lysine HCl in immunopotentiation towards development of suitable tuberculosis vaccination . Vaccine vol. 21 , ( 32 ) 4722 - 4727 .

Calladine CR, Pratap V, Chandran V, Mizuguchi K, Luisi BF ( 2003 ) . Cylindrical Channels from Concave Helices . Science vol. 299 , ( 5607 ) 661 - 662 .

Datta D, Bhinge A, Chandran V ( 2001 ) . Lysine: Is it worth more? . Cytotechnology vol. 36 , ( 1-3 ) 3 - 32 .

Datta D, Kundu PK, Biswas S, Dasgupta S, Bhinge A, Chandran V ( 2000 ) . Effect of Cationic Amino Acid, L-Lysine and its Polymers on the Growth and Secretion of Hybridoma Cell Line OKT-3 . Hybridoma vol. 19 , ( 4 ) 339 - 346 .