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Research
  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: DR Sabarinath Vallath

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( 2019 ) . The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy . The Journal of Pathology vol. 249 , ( 3 ) 332 - 342 .
Kolluri KK, Alifrangis C, Kumar N, Ishii Y, Price S, Michaut M, Williams S, Barthorpe S et al. ( 2018 ) . Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells . eLife vol. 7 , Article e30224 ,
Whilding LM, Parente-Pereira AC, Zabinski T, Davies DM, Petrovic RMG, Kao YV, Saxena SA, Romain A et al. ( 2017 ) . Targeting of Aberrant αvβ6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells . Molecular Therapy vol. 25 , ( 10 ) 2427 - 2427 .
Whilding LM, Parente-Pereira AC, Zabinski T, Davies DM, Petrovic RMG, Kao YV, Saxena SA, Romain A et al. ( 2017 ) . Targeting of Aberrant αvβ6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells . Molecular Therapy vol. 25 , ( 1 ) 259 - 273 .
Vallath S, Reader C, Morton J, Sansom O, Evans J, Biankin A, Barry ST, Kocher H et al. ( 2016 ) . Abstract B53: The integrin αvβ6 is a promising therapeutic target for treating PDAC . Cancer Research . vol. 76 , B53 - B53 .
Seedhar P, Sage EK, Vallath S, Sturges G, Giangreco A ( 2016 ) . Cadm1 regulates airway stem cell growth and differentiation via modulation of Stat3 activity .
Agrawal T, Chan W-Y, Sage E, Kolluri K, Sladen P, Sturges G, Vallath S, Janes S et al. ( 2016 ) . Epithelial ErbB2 activity determines thymus homeostasis and T cell maturation . The Journal of Immunology vol. 196 , ( 1_Supplement ) 194.11 - 194.11 .
Whilding LM, Vallath S, Maher J ( 2016 ) . The integrin αvβ6: a novel target for CAR T-cell immunotherapy? . Biochemical Society Transactions vol. 44 , ( 2 ) 349 - 355 .
Vallath S, Sage EK, Kolluri KK, Lourenco SN, Teixeira VS, Chimalapati S, George PJ, Janes SM et al. ( 2016 ) . CADM1 inhibits squamous cell carcinoma progression by reducing STAT3 activity . Scientific Reports vol. 6 , ( 1 ) Article 24006 ,
Whilding LM, Parente-Pereira AC, Zabinski T, Davies DM, Petrovic R, Violette S, Ghaem-Maghami S, Vallath S et al. ( 2016 ) . Abstract B129: Chimeric antigen receptor T-cells targeting the αvβ6 integrin demonstrate potent antitumor activity in multiple solid tumors . Cancer Immunology Research . vol. 4 , B129 - B129 .
Reader CS, Vallath S, Morton J, Steele C, Kocher HM, Keyse SM, Sansom O, Marshall JF ( 2015 ) . Abstract B87: Cell lines generated from PDAC transgenic mice reveal integrin αvβ6 modifies the invasive phenotype of pancreatic cancer . Cancer Research . vol. 75 , B87 - B87 .
( 2014 ) . Abstract B046: Therapeutic targeting of integrin αvβ6 in high-risk breast cancer . Molecular Cancer Research vol. 11 , ( 10_Supplement ) B046 - B046 .
( 2014 ) . Therapeutic Targeting of Integrin αvβ6 in Breast Cancer . JNCI: Journal of the National Cancer Institute vol. 106 , ( 8 )
Vallath S, Gadaletta E, Chelala C, Scarpa A, Hart IR, Kocher HM, Marshall JF ( 2012 ) . Abstract B42: Toward targeting integrin αvβ6 for the therapy of pancreatic cancer . Therapy . Conference: Abstracts: AACR Special Conference on Pancreatic Cancer: Progress and Challenges; June 18-21, 2012; Lake Tahoe, NVB42 - B42 .
( 2014 ) . Correction . Thorax vol. 69 , ( 3 ) 253 - 253 .
Allen MD, Thomas GJ, Clark S, Dawoud MM, Vallath S, Payne SJ, Gomm JJ, Dreger SA et al. ( 2014 ) . Altered Microenvironment Promotes Progression of Preinvasive Breast Cancer: Myoepithelial Expression of αvβ6 Integrin in DCIS Identifies High-risk Patients and Predicts Recurrence . Clinical Cancer Research vol. 20 , ( 2 ) 344 - 357 .
Vallath S, Hynds RE, Succony L, Janes SM, Giangreco A ( 2014 ) . Targeting EGFR signalling in chronic lung disease: therapeutic challenges and opportunities . European Respiratory Journal vol. 44 , ( 2 ) 513 - 522 .
Vallath S, Sage EK, Teixeira VH, Janes SM, Giangreco A ( 2013 ) . S130 Role of CADM1 in squamous cell carcinoma progression . Thorax vol. 68 , ( Suppl 3 ) A67.1 - A67 .
Coughlan L, Vallath S, Gros A, Giménez-Alejandre M, Van Rooijen N, Thomas GJ, Baker AH, Cascalló M et al. ( 2012 ) . Combined Fiber Modifications Both to Target α<sub>v</sub>β<sub>6</sub>and Detarget the Coxsackievirus–Adenovirus Receptor Improve Virus Toxicity Profiles<i>In Vivo</i>but Fail to Improve Antitumoral Efficacy Relative to Adenovirus Serotype 5 . Human Gene Therapy vol. 23 , ( 9 ) 960 - 979 .
( 2011 ) . Clinical and functional significance of alpha 9 beta 1 integrin expression in breast cancer: a novel cell-surface marker of the basal phenotype that promotes tumour cell invasion . J PATHOL vol. 223 , ( 5 ) 646 - 658 .
Marsh D, Suchak K, Moutasim KA, Vallath S, Hopper C, Jerjes W, Upile T, Kalavrezos N et al. ( 2011 ) . Stromal features are predictive of disease mortality in oral cancer patients . J PATHOL vol. 223 , ( 4 ) 470 - 481 .
Marsh D, Suchak K, Moutasim KA, Vallath S, Hopper C, Jerjes W, Upile T, Kalavrezos N et al. ( 2011 ) . Stromal features are predictive of disease mortality in oral cancer patients . The Journal of pathology vol. 223 , ( 4 ) 470 - 481 .
Filipovic A, Gronau JH, Green AR, Wang J, Vallath S, Shao DM, Rasul S, Ellis IO et al. ( 2011 ) . Biological and clinical implications of nicastrin expression in invasive breast cancer . BREAST CANCER RES TR vol. 125 , ( 1 ) 43 - 53 .
Marsh D, Suchak K, Moutasim K, Vallath S, Hopper C, Jerjes W, Upile T, Kalavrezos N et al. ( 2011 ) . Stromal features are predictive of disease mortality in oral cancer patients . J Pathol vol. 4 , ( 223 ) 470 - 481 .
Saha A, Ellison D, Thomas GJ, Vallath S, Mather SJ, Hart IR, Marshall JF ( 2010 ) . High-resolution in vivo imaging of breast cancer by targeting the pro-invasive integrin alpha v beta 6 . J PATHOL vol. 222 , ( 1 ) 52 - 63 .
Wagstaff JL, Vallath S, Marshall JF, Williamson RA, Howard MJ ( 2010 ) . Two-dimensional heteronuclear saturation transfer difference NMR reveals detailed integrin alpha v beta 6 protein-peptide interactions . CHEM COMMUN vol. 46 , ( 40 ) 7533 - 7535 .
Jones J, Allen M, Thomas G, Dawoud M, Vallath S, Payne S, Edwards D, Pennington C et al. ( 2009 ) . DCIS-Associated Myoepithelial Cells Expressing the αvβ6 Integrin Modify Tumour Cell Behaviour: A Predictor of Invasive Progression? . Cancer Research vol. 69 , ( 24_Supplement ) 4159 - 4159 .
Coughlan L, Vallath S, Saha A, Flak M, McNeish IA, Vassaux G, Marshall JF, Hart IR et al. ( 2009 ) . In Vivo Retargeting of Adenovirus Type 5 to alpha v beta 6 Integrin Results in Reduced Hepatotoxicity and Improved Tumor Uptake following Systemic Delivery . J VIROL vol. 83 , ( 13 ) 6416 - 6428 .
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