Publications: DR Donato Iacovazzo

Kaniuka-Jakubowska S, Kaszubowski M, Davis J, Abeyaratne D, Akker S, Archer N, Ayuk J, Drake W et al. ( 2025 ) . Pituitary gigantism: what differences beyond height can we expect compared to acromegaly? a comparison of clinical features and mortality in 3244 patients . Endocrine Abstracts

Loughrey PB, Mothojakan NB, Iacovazzo D, Arni A, Aflorei ED, Arnaldi G, Barlier A, Beckers A et al. ( 2025 ) . Reassessing the role of the p.(Arg304Gln) missense AIP variant in pituitary tumorigenesis . European Journal of Endocrinology vol. 192 , ( 4 ) 385 - 397 .

Christ E, Iacovazzo D, Korbonits M ( 2023 ) . Insulinomatosis: new aspects . Endocrine Related Cancer vol. 30 , ( 6 )

Walker EM, Cha J, Tong X, Liu J-H, Iacovazzo D, Mauvais-Jarvis F, Flanagan SE, Stafford J ( 2021 ) . Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males . Cell Reports vol. 37 , ( 2 )

Nadhamuni VS, Iacovazzo D, Evanson J, Sahdev A, Trouillas J, Hussain K ( 2021 ) . GHRH secretion from a pancreatic neuroendocrine tumor causing gigantism in a patient with MEN1 . Endocrinology Diabetes and Metabolism Case Reports vol. 2021 , 20 - 0208 .

Loughrey PB, Baker G, Herron B, Cooke S, Lindsay ( 2021 ) . Invasive ACTH-Producing Pituitary Gland Neoplasm Secondary to MSH2 Mutation . Cancer Genetics

Marques P, Caimari F, Hernandez-Ramirez LC, Collier D, Iacovazzo D, Ronaldson A, Stals K ( 2020 ) . Significant benefits of AIP testing and clinical screening in familial isolated and young-onset pituitary tumors .

Iacovazzo D, Thong LC, Quezado R, Drummond J, Antonio DSBF, Cuenco J, Brändle M, Walker E et al. ( 2020 ) . The MAFA gene mutation responsible for familial insulinomatosis and diabetes impairs insulin secretion and results in downregulation of critical cell cycle regulators . Endocrine Abstracts

CHA J, WALKER EM, TONG X, GUO M, LIU JH, YU S, IACOVAZZO D, MAUVAIS-JARVIS F et al. ( 2020 ) . 2116-P: MAFA S64F Missense Mutation Causes Islet Beta-Cell Aging and Senescence . Diabetes vol. 69 , ( Supplement_1 )

Marques P, Caimari F, Hernández-Ramírez LC, Collier D, Iacovazzo D, Ronaldson A, Magid K, Lim CT et al. ( 2020 ) . Significant Benefits of AIP Testing and Clinical Screening in Familial Isolated and Young-onset Pituitary Tumors . The Journal of Clinical Endocrinology & Metabolism vol. 105 , ( 6 )

Iacovazzo D, Chiloiro S, Carlsen E, Bianchi A, Giampietro A, Tartaglione T, Bima C, Bracaccia ME et al. ( 2019 ) . Tumour-infiltrating cytotoxic T lymphocytes in somatotroph pituitary neuroendocrine tumours . Endocrine vol. 67 , ( 3 ) 651 - 658 .

Nadhamuni VS, Iacovazzo D, Evanson J, Trouillas J, Kurzawinski T ( 2019 ) . Unusual cause of gigantism - Growth hormone releasing hormone (GHRH)-secreting pancreatic neuroendocrine tumour in a patient with multiple endocrine neoplasia type 1 (MEN1) . Endocrine Abstracts

Dutta P, Reddy KS, Rai A, Madugundu AK, Solanki HS, Bhansali A, Radotra BD, Kumar N et al. ( 2019 ) . Surgery, Octreotide, Temozolomide, Bevacizumab, Radiotherapy, and Pegvisomant Treatment of an AIP Mutation‒Positive Child . The Journal of Clinical Endocrinology & Metabolism vol. 104 , ( 8 ) 3539 - 3544 .

Pepe S, Korbonits M, Iacovazzo D ( 2019 ) . Germline and mosaic mutations causing pituitary tumours: genetic and molecular aspects . Journal of Endocrinology vol. 240 , ( 2 ) r21 - r45 .

Yang ZJ, Lillina VM, Collier D, Thong LC, Awad S ( 2018 ) . Identifying disease causing variants in aryl hydrocarbon receptor-interacting protein (AIP) variants and their significance on the clinical phenotypes . Endocrine Abstracts

Caimari F, Hernández-Ramírez LC, Dang MN, Gabrovska P, Iacovazzo D ( 2018 ) . Risk category system to identify pituitary adenoma patients with AIP mutations . Journal of Medical Genetics vol. 55 , ( 4 )

Imran SA, Aldahmani KA, Penney L, Croul SE, Clarke DB, Collier DM ( 2018 ) . Unusual AIP mutation and phenocopy in the family of a young patient with acromegalic gigantism . Endocrinol Diabetes Metab Case Rep vol. 2018 ,

Iacovazzo D, Flanagan SE, Walker E, Quezado R, de Sousa Barros FA, Caswell R, Johnson MB, Wakeling M et al. ( 2018 ) . MAFA missense mutation causes familial insulinomatosis and diabetes mellitus . Proc Natl Acad Sci U S A vol. 115 , ( 5 ) 1027 - 1032 .

Iacovazzo D, Kumar A, Abbs S, Solomon A, Korbonits M, Druce M ( 2017 ) . A novel variant in the androgen receptor gene causing familial mild androgen insensitivity syndrome . Endocrine Abstracts

Koehler VF, Jungheim K, Groß U, Iacovazzo D ( 2017 ) . Novel Germline p.Gly42Val MEN1 Mutation in a Family with Multiple Endocrine Neoplasia Type 1 - Excellent Response of Prolactinoma to Cabergoline . Ann Clin Lab Sci vol. 47 , ( 5 ) 606 - 610 .

Kiefer FW, Winhofer Y, Iacovazzo D, Wolfsberger S, Trautinger F, Höftberger R, Luger A ( 2017 ) . PRKAR1A mutation causing pituitary-dependent Cushing disease in a patient with Carney complex . Eur J Endocrinol vol. 177 , ( 2 ) K7 - K12 .

Amarawardena WKMG, Newell-Price JDC, Ross RJM, Iacovazzo D, Debono M ( 2017 ) . Pasireotide: successful treatment of a sparsely granulated tumour in a resistant case of acromegaly . Endocrinol Diabetes Metab Case Rep vol. 2017 ,

Salvatori R, Radian S, Diekmann Y, Iacovazzo D, David A, Gabrovska P, Grassi G, Bussell A-M et al. ( 2017 ) . In-frame seven amino-acid duplication in AIP arose over the last 3000 years, disrupts protein interaction and stability and is associated with gigantism . Eur J Endocrinol vol. 177 , ( 3 ) 257 - 266 .

Bima C, Chiloiro S, Iacovazzo D, Tartaglione T, Bracaccia ME, Giampietro A, Bianchi A, De ML ( 2017 ) . Biochemical normalization in acromegaly after 79 months' treatment with Pasireotide: case report . Endocrine Abstracts

Iacovazzo D, Hernández-Ramírez LC ( 2017 ) . Sporadic pituitary adenomas: the role of germline mutations and recommendations for genetic screening . Expert Review of Endocrinology and Metabolism vol. 12 , ( 2 ) 143 - 153 .

Roncaroli F, Iacovazzo D, Rodd C, Gurlek A, Dutta P, Ellard S, Korbonits M ( 2017 ) . Distinct pathological features of pituitary adenomas in patients with X-linked acrogigantism (XLAG) . NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY . Conference: 118th Meeting of the British-Neuropathological-Society vol. 43 , 20 - 20 .

Iacovazzo D, Flanagan SE, Walker E, Caswell R, Brandle M, Johnson M, Wakeling M, Dang MN et al. ( 2016 ) . A missense mutation in the islet-enriched transcription factor MAFA leads to familial insulinomatosis and diabetes . Endocrine Abstracts

Afghan WK, Iacovazzo D, Alevizaki M, Foulkes W, Lugli F, Druce M, Dutta P, Dang MN et al. ( 2016 ) . ESR2 mutations in RET mutation-negative familial medullary thyroid carcinoma . Endocrine Abstracts

Mothojakan NB, Ferrau F, Dang MN, Barlier A, Chanson P, Occhi G, Daly AF, Schofl C et al. ( 2016 ) . Polymorphism or mutation? - The role of the R304Q missense AIP mutation in the predisposition to pituitary adenoma . Endocrine Abstracts

Iacovazzo D ( 2016 ) . Gigantism: X-linked acrogigantism and GPR101 mutations . Growth Horm IGF Res vol. 30-31 , 64 - 69 .

Hernández-Ramírez LC, Martucci F, Morgan RML, Trivellin G, Tilley D, Iacovazzo D ( 2016 ) . Rapid Proteasomal Degradation of Mutant Proteins Is the Primary Mechanism Leading to Tumorigenesis in Patients With Missense AIP Mutations . Journal of Clinical Endocrinology and Metabolism vol. 101 , ( 8 ) 3144 - 3154 .

Iacovazzo D, Caswell R, Bunce B, Jose S, Yuan B, Hernández-Ramírez LC, Kapur S, Caimari F et al. ( 2016 ) . Germline or somatic GPR101 duplication leads to X-linked acrogigantism: a clinico-pathological and genetic study . Acta Neuropathologica Communications vol. 4 , ( 1 )

Giampietro A, Chiloiro S, Mormando M, Bima C, Bracaccia ME, Piacentini S, Tartaglione L, Iacovazzo D et al. ( 2016 ) . Bone metabolism in acromegaly . Endocrine Abstracts

Rodd C, Millette M, Iacovazzo D, Stiles CE, Barry S, Evanson J, Albrecht S, Caswell R et al. ( 2016 ) . Somatic GPR101 Duplication Causing X-Linked Acrogigantism (XLAG)—Diagnosis and Management . The Journal of Clinical Endocrinology & Metabolism vol. 101 , ( 5 ) 1927 - 1930 .

Ramírez-Rentería C, Hernández-Ramírez LC, Portocarrero-Ortiz L, Vargas G, Melgar V, Espinosa E, Espinosa-de-los-Monteros AL, Sosa E et al. ( 2016 ) . AIP mutations in young patients with acromegaly and the Tampico Giant: the Mexican experience . Endocrine vol. 53 , ( 2 ) 402 - 411 .

Losa M, Bogazzi F, Cannavo S, Ceccato F, Curtò L, Iacovazzo D, Lombardi G, Mantovani G et al. ( 2016 ) . Temozolomide therapy in patients with aggressive pituitary adenomas or carcinomas . Journal of Neuro Oncology vol. 126 , ( 3 ) 519 - 525 .

Koehler VF, Jungheim K, Gross U, Iacovazzo D, Korbonits M ( 2016 ) . Novel germline p.Gly42Val MEN1 mutation in a family with multiple endocrine neoplasia type 1 .

Losa M, Bogazzi F, Cannavo S, Ceccato F, De Marinis L, Iacovazzo D, Mantovani G, Mazza E et al. ( 2015 ) . Temozolomide therapy in patients with aggressive pituitary adenomas or carcinomas . Journal of Neuro-Oncology vol. 126 , ( 3 ) 519 - 525 .

Iacovazzo D, Carlsen E, Lugli F, Chiloiro S, Piacentini S, Bianchi A, Giampietro A, Mormando M et al. ( 2015 ) . Factors predicting pasireotide responsiveness in somatotroph pituitary adenomas resistant to first-generation somatostatin analogues: an immunohistochemical study . European Journal of Endocrinology vol. 174 , ( 2 ) 241 - 250 .

Coxson E, Iacovazzo D, Bunce B, Jose S, Sampson J, Korbonits M ( 2015 ) . Pegvisomant treatment for X-linked acrogigantism syndrome . Endocrine Abstracts

Iacovazzo D, Jose S, Bunce B, Caswell R, Hernandez-Ramirez LC, Caimari F, Ferrau F, Kapur S et al. ( 2015 ) . Unique clinical picture in patients with X-linked acrogigantism . Endocrine Abstracts

Farchione A, Rufini V, Brizi MG, Iacovazzo D, Larghi A, Massara RM, Petrone G, Poscia A et al. ( 2015 ) . Evaluation of the Added Value of Diffusion-Weighted Imaging to Conventional Magnetic Resonance Imaging in Pancreatic Neuroendocrine Tumors and Comparison With 68Ga-DOTANOC Positron Emission Tomography/Computed Tomography . Pancreas

Hernández-Ramírez LC, Gabrovska P, Dénes J, Stals K, Trivellin G, Tilley D, Ferraù F, Evanson J et al. ( 2015 ) . Landscape of Familial Isolated and Young-Onset Pituitary Adenomas: Prospective Diagnosis in AIP Mutation Carriers . The Journal of Clinical Endocrinology & Metabolism vol. 100 , ( 9 ) e1242 - e1254 .

Chiloiro S, Doglietto F, Trapasso B, Iacovazzo D, Giampietro A, Di Nardo F, De Waure C, Lauriola L et al. ( 2015 ) . Typical and atypical pituitary adenomas: A single-center analysis of outcome and prognosis . Neuroendocrinology vol. 101 , ( 2 ) 143 - 150 .

Chiloiro S, Doglietto F, Iacovazzo D, Giampietro A, Di NF, de WC, Lauriola L, Mangiola A et al. ( 2015 ) . Outcome and prognosis of typical and atypical pituitary adenomas in a monocentric experience . Endocrine Abstracts

Iacovazzo D, Lugli F, Piacentini S, Bianchi A, Inzani F, Larocca LM, De Marinis L ( 2015 ) . Systemic mastocytosis mimicking carcinoid syndrome . Endocrine vol. 48 , ( 2 ) 718 - 719 .

Iacovazzo D ( 2015 ) . Treatment of hyperprolactinemia in post-menopausal women: pros . Endocrine vol. 48 , ( 1 ) 76 - 78 .

Chiloiro S, Doglietto F, Trapasso B, Giampietro A, Di Nardo F, Lauriola L, Mangiola A, Anile C ( 2015 ) . Typical and Atypical Pituitary Adenomas: A Single-Center Analysis of Outcome and Prognosis . Neuroendocrinology vol. 101 , ( 2 ) 143 - 150 .

Iacovazzo D, Piacentini S, Lugli F, Bianchi A, Persiani R, Korbonits M ( 2015 ) . A Novel MEN1 Gene Variant in a Sporadic Case of Multiple Endocrine Neoplasia Type 1 . NEUROENDOCRINOLOGY . vol. 102 , 150 - 150 .

Piacentini S, Iacovazzo D, Lugli F, Giampietro A, Bianchi A, Chiloiro S ( 2015 ) . Two Cases of Ectopic ACTH-Secreting Neoplasm of Occult Origin Becoming Overt after Bilateral Adrenalectomy . NEUROENDOCRINOLOGY . vol. 102 , 153 - 153 .

Iacovazzo D ( 2014 ) . Treatment of hyperprolactinemia in post-menopausal women: pros . Endocrine vol. 48 , ( 1 ) 76 - 78 .

Chiloiro S, Bianchi A, Giampietro A, Iacovazzo D, Trapasso B, Tartaglione L . Correlation between atypical pituitary adenomas and Ki-67 Li: clinical and prognostic aspects . Endocrine Abstracts .

Iacovazzo D, Lugli F, Capoluongo E, Lucci-Cordisco E, Persiani R, Doglietto GB, Pontecorvi A, Rindi G . Efficacy of lanreotide autogel in men1-related gastrinomas: a case series . Endocrine Abstracts .

Lugli F, Iacovazzo D, Lanza P, Waure CD, Rindi G . Evaluation of vegf and endocan/esm-1 expression in pnets and correlation with Ki67 and prognosis . Endocrine Abstracts .

Bianchi A, Tartaglione L, Giampietro A, Milardi D, Angelini F, Mormando M, Lugli F, Piacentini S et al. ( 2014 ) . IGF1 response to rhGH in adult GHD: role of GH receptor (GHR) isoforms . Endocrine Abstracts

Iacovazzo D, Lugli F, Piacentini S, Bianchi A ( 2014 ) . Systemic mastocytosis mimicking carcinoid syndrome . Endocrine vol. 48 , ( 2 ) 718 - 719 .

Iacovazzo D, Morrison P, Foulkes W, Ross D, Lugli F, Neri G, Korbonits M ( 2014 ) . RET mutation negative familial medullary thyroid carcinoma: four families and literature review . Endocrine Abstracts

Bianchi A, Tartaglione L, Giampietro A, Milardi D, Angelini F, Mormando M, Lugli F, Grande G et al. ( 2014 ) . Determinants of IGF-I Response to Rhgh in Adult Ghd: Role of GH Receptor (GHR) Isoforms . ENDOCRINE REVIEWS vol. 35 , ( 3 )

Iacovazzo D, Lugli F, Bianchi A, Capoluongo E, Lucci-Cordisco E, Persiani R, Pontecorvi A ( 2014 ) . Efficacy of Lanreotide Autogel in MEN1-Related Gastrinoma: A Case Series . NEUROENDOCRINOLOGY . vol. 99 , 272 - 272 .

Lugli F, Iacovazzo D, Lanza P, De Waure C ( 2014 ) . Evaluation of VEGF and Endocan/Esm-1 Expression in Pnets and Correlation with Ki-67 and Prognosis . ENDOCRINE REVIEWS . vol. 35 ,

Farchione A, Rufini V, Brizi MG, Lanza F, Iacovazzo D, Larghi A, Massara RM, Petrone G ( 2014 ) . Evaluation of the Added Value of Diffusion-Weighted Imaging to Conventional MRI in Pancreatic Neuroendocrine Tumors and Comparison with 68Ga-DOTANOC PET/CT . NEUROENDOCRINOLOGY . vol. 99 , 260 - 260 .

Iacovazzo D, Sampson JR, Morrison PJ, Foulkes W, Lugli F, Lucci-Cordisco E ( 2014 ) . Five families with RET-mutation negative familial medullary thyroid carcinoma: what lies beyond RET? . WIENER KLINISCHE WOCHENSCHRIFT vol. 126 , S141 - S142 .

Iacovazzo D, Morrison PJ, Foulkes W, Ross DS, Lugli F, Gabrovska P ( 2014 ) . Four Families with RET-Mutation Negative Familial Medullary Thyroid Carcinoma: What Lies Beyond RET? . ENDOCRINE REVIEWS vol. 35 , ( 3 )

Lugli F, Iacovazzo D, Piacentini S, Giampietro A, Doglietto F, Balducci M, Maira G ( 2014 ) . Temozolomide: A Useful Treatment for an Aggressive ACTH Secreting Pituitary Adenoma . ENDOCRINE REVIEWS . vol. 35 ,

Chiloiro S, Bianchi A, Doglietto F, de Waure C, Giampietro A, Fusco A, Iacovazzo D, Tartaglione L et al. ( 2013 ) . Radically resected pituitary adenomas: prognostic role of Ki 67 labeling index in a monocentric retrospective series and literature review . Pituitary vol. 17 , ( 3 ) 267 - 276 .

Iacovazzo D, Lugli F, Plastino F, Schinzari G, Bianchi A, Fusco A, Rindi G, Pontecorvi A et al. ( 2013 ) . Everolimus treatment in a series of patients with advanced neuroendocrine tumors . Endocrine Abstracts

Fusco A, Bianchi A, Giampietro A, Iacovazzo D, Lugli F, Chiloiro S, Piacentini S, Tartaglione L et al. ( 2013 ) . Factors Affecting Prognosis in a Series of Acromegalic Patients . Endocrine Abstracts

Treglia G, Iacovazzo D, Caldarella C, Muoio B, Bianchi A ( 2013 ) . A Rare Case of Malignant Granular Cell Tumor of the Colon Incidentally Detected by 18 F-FDG Positron Emission Tomography/Computed Tomography . Nuclear Medicine and Molecular Imaging vol. 47 , ( 2 ) 148 - 150 .

Iacovazzo D, Bianchi A, Lugli F, Milardi D, Giampietro A, Lucci-Cordisco E, Doglietto F ( 2013 ) . Double pituitary adenomas . Endocrine vol. 43 , ( 2 ) 452 - 457 .

Fusco A, Giampietro A, Bianchi A, Tartaglione L, Cimino V, Chiloiro S, Iacovazzo D, Piacentini S et al. ( 2012 ) . P02-41 Non alcoholic fatty liver disease is associated with increased GHBP and reduced GH/IGF-1 levels . Growth Hormone & IGF Research vol. 22 , s64 - s65 .

Iacovazzo D, Giampietro A ( 2012 ) . Ectopic posterior pituitary causing hyperprolactinemia . Endocrine vol. 42 , ( 2 ) 449 - 450 .

Iacovazzo D, Lugli F, Bianchi A, Cimino V, Grande G, Treglia G, Granone PM ( 2012 ) . A Case of ACTH-Secreting Bronchial Carcinoid . NEUROENDOCRINOLOGY . vol. 96 , 38 - 38 .

Larghi A, Fusco A, Lugli F, Iacovazzo D, Celico M, Pontecorvi A, Rindi G ( 2012 ) . Endoscopic Ultrasound-Guided Fine Needle Tissue Acquisition (EUS-FNTA) Using a 19-G Needle for Histological Grading of Pancreatic Endocrine Tumors (PETs): A Prospective Study . NEUROENDOCRINOLOGY . vol. 96 , 44 - 44 .

Bianchi A, Iacovazzo D, Plastino F, Lugli F, Giordano A, Barone CAM ( 2012 ) . Establishment of a Multidisciplinary Tumor Board for Patients with Neuroendocrine Neoplasms . NEUROENDOCRINOLOGY . vol. 96 , 21 - 21 .

Lugli F, Iacovazzo D, Bianchi A, Chiloiro S, Tartaglione L, Giaccari A ( 2012 ) . Insulin Autoimmune Syndrome Mimicking Insulinoma: A Challenging Diagnosis . NEUROENDOCRINOLOGY . vol. 96 , 44 - 44 .

Bianchi A, Iacovazzo D, Fusco A, Lugli F, Giampietro A, Lorusso M, D'Uonnolo A, Pontecorvi A ( 2011 ) . Medical and Peptide Receptor Radionuclide Therapy (PRRT) with Somatostatin Analogues (SSA) in Well- and Moderately Differentiated Neuroendocrine Tumors . NEUROENDOCRINOLOGY . vol. 94 , 16 - 17 .

Iacovazzo D, Lugli F, Fusco A, Bianchi A, Schinzari G, Rindi G ( 2011 ) . Pancreatic Metastases from Bronchopulmonary Atypical Carcinoid: An Uncommon Tumor Spreading to a Rare Location . NEUROENDOCRINOLOGY . vol. 94 , 27 - 27 .

Fusco A, Bianchi A, Giampietro A, Tilaro L, Veltri F, Piacentini S, Iacovazzo D, Lorusso M et al. ( 2010 ) . The Clinical Experience at a Single Centre with Pegvisomant Therapy in Acromegaly . ENDOCRINE REVIEWS . vol. 31 ,

Fusco A, Lugli F, Bianchi A, Iacovazzo D, Tartaglione L, Piacentini S, Perotti G, Doglietto G ( 2010 ) . The Importance of Endoscopic Ultrasound in Detecting Recurrent Gastrinoma in a Case of MEN 1 . NEUROENDOCRINOLOGY . vol. 92 , 30 - 31 .

Lugli F, Fusco A, Bianchi A, Iacovazzo D, Mormando M, Doglietto G ( 2010 ) . The Role of 18F DOPA-PET in a Case of Malignant Pheochromocytoma . NEUROENDOCRINOLOGY . vol. 92 , 43 - 43 .

KORBONITS MJ . Germline or somatic GPR101 duplication leads to X-linked acrogigantism: a clinico-pathological and genetic study . Acta Neuropathologica Communications

TUFTON NK, akker S . SDHA mutated paragangliomas may be at high risk of metastasis . Endocrine-Related Cancer

Walker EM, Cha J, Tong X, Guo M, Liu J-H, Yu S, Iacovazzo D, Mauvais-Jarvis F et al. . Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males .