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Research

Publications: DR Melanie Smuk

Ring K, Smuk M, Radix A, Brady M, Nambiar KZ, Orkin C, Miles S ( 2025 ) . Exploring pronoun use amongst HIV and sexual health clinic staff in the UK: A mixed methods analysis . International Journal of Transgender Health vol. ahead-of-print , ( ahead-of-print ) 1 - 18 .
James M, Smuk M, Rahman N, Black G, Alazawi W ( 2025 ) . Epidemiology of Metabolic Dysfunction–Associated Steatotic Liver Disease in South Asian Ethnicities: A Systematic Review and Meta‐Analysis . Journal of Gastroenterology and Hepatology
Elias A, Pasin C, Smuk M, Paterson A, Orkin CM ( 2025 ) . Outcomes of real‐world initiation of long‐acting injectable cabotegravir and rilpivirine (LA‐I CAB + RPV) in individuals with viraemia: A systematic review of baseline characteristics, virological failure outcomes and discontinuations . HIV Medicine
Slade M, Rennick-Egglestone S, Ali Y, Newby C, Yeo C, Roe J, Hui A, Charles A et al. ( 2025 ) . Recorded mental health recovery narratives for people with mental health problems and informal carers: the NEON research programme including 3 RCTs . Programme Grants for Applied Research1 - 54 .
Orkin C, Paterson A, Elias A, Smuk M, Ring K, Volny-Anne A, Calmy A, Hazra A et al. ( 2025 ) . Establishing shared definitions of virological failure and discontinuation for long-acting injectable cabotegravir and rilpivirine therapy (the CONSENSUS-LAI Study): an international survey and Delphi process . The Lancet HIV vol. 12 , ( 9 ) e649 - e659 .
Hayes R, Smuk M, Kasadha B, Halim N, Apea V, Paparini S, Orkin CM ( 2025 ) . Achieving equitable recruitment through inclusive protocol design: lessons learned from the ILANA study . Trials vol. 26 , ( 1 )
Ring K, Elias A, Devonald M, Smuk M, Orkin C ( 2025 ) . Long‐acting injectable cabotegravir and rilpivirine in observational cohort studies: A systematic review on virological failure, resistance and re‐suppression outcomes in virally suppressed individuals living with HIV . HIV Medicine vol. 26 , ( 8 ) 1267 - 1288 .
Chasekwa B, Munhanzi F, Madhuyu L, Mbewe G, Mabika V, Chidhanguro D, Kofi T, Munengiwa J et al. ( 2025 ) . A Trial of Trimethoprim–Sulfamethoxazole in Pregnancy to Improve Birth Outcomes . The New England Journal of Medicine vol. 392 , ( 21 ) 2125 - 2134 .
Bwakura-Dangarembizi M, Amadi B, Singa BO, Muyemayema S, Ngosa D, Mwalekwa L, Ngao N, Kazhila L et al. ( 2025 ) . An adaptive multiarm randomised trial of biomedical and psychosocial interventions to improve convalescence following severe acute malnutrition in sub-Saharan Africa: Co-SAM trial protocol . BMJ Open vol. 15 , ( 5 )
Apea V, Titanji BK, Dakin FH, Hayes R, Smuk M, Kawu H, Waters L, Levy I et al. ( 2025 ) . International healthcare workers’ experiences and perceptions of the 2022 multi-country mpox outbreak . PLOS Global Public Health vol. 5 , ( 2 )
Piper JD, Mazhanga C, Mwapaura M, Mapako G, Mapurisa I, Mashedze T, Munyama E, Kuona M et al. ( 2024 ) . School-age growth and development following infant feeding and/or water, sanitation, and hygiene interventions in rural Zimbabwe: long-term follow-up of a cluster-randomised trial . EClinicalMedicine vol. 78 ,
Slade M, Rennick-Egglestone S, Robinson C, Newby C, Elliott RA, Ali Y, Yeo C, Glover T et al. ( 2024 ) . Effectiveness and cost-effectiveness of online recorded recovery narratives in improving quality of life for people with psychosis experience (NEON Trial): a pragmatic randomised controlled trial . The Lancet Regional Health - Europe vol. 47 ,
Piper JD, Mazhanga C, Mwapaura M, Mapako G, Mapurisa I, Mashedze T, Munyama E, Kuona M et al. ( 2024 ) . Growth, physical, and cognitive function in children who are born HIV-free: School-age follow-up of a cluster-randomised trial in rural Zimbabwe . PLOS Medicine vol. 21 , ( 10 )
Allotey J, Archer L, Snell KIE, Coomar D, Massé J, Sletner L, Wolf H, Daskalakis G et al. ( 2024 ) . Development and validation of a prognostic model to predict birth weight: individual participant data meta-analysis . BMJ Medicine vol. 3 , ( 1 )
Allotey J, Archer L, Coomar D, Snell KI, Smuk M, Oakey L, Haqnawaz S, Betrán AP et al. ( 2024 ) . Development and validation of prediction models for fetal growth restriction and birthweight: an individual participant data meta-analysis . Health Technology Assessment vol. 28 , ( 47 ) 1 - 119 .
Piper JD, Mazhanga C, Mapako G, Mapurisa I, Mashedze T, Munyama E, Mwapaura M, Chidhanguro D et al. ( 2024 ) . Piloting the adaptation of the Kaufman Assessment Battery for Children—2 nd edition (KABC-II) to assess school-age neurodevelopment in rural Zimbabwe . Wellcome Open Research vol. 7 ,
Havers L, Bhui K, Shuai R, Fonagy P, Fazel M, Morgan C, Fancourt D, McCrone P et al. ( 2024 ) . A cross‐sectional investigation into the role of intersectionality as a moderator of the relation between youth adversity and adolescent depression/anxiety symptoms in the community . Journal of Adolescence vol. 96 , ( 6 ) 1304 - 1315 .
Havers L, Shuai R, Fonagy P, Fazel M, Morgan C, Fancourt D, McCrone P, Smuk M et al. ( 2024 ) . Youth adversity and trajectories of depression/anxiety symptoms in adolescence in the context of intersectionality in the United Kingdom . Psychological Medicine vol. 54 , ( 10 ) 2677 - 2687 .
Sturgeon JP, Tome J, Dumbura C, Majo FD, Ngosa D, Mutasa K, Zyambo K, Besa E et al. ( 2024 ) . Inflammation and epithelial repair predict mortality, hospital readmission, and growth recovery in complicated severe acute malnutrition . Science Translational Medicine vol. 16 , ( 736 ) eadh0673 - eadh0673 .
Mathur S, Smuk M, Evans C, Wedderburn CJ, Gibb DM, Penazzato M, Prendergast AJ ( 2024 ) . Estimating the impact of alternative programmatic cotrimoxazole strategies on mortality among children born to mothers with HIV: A modelling study . PLOS Medicine vol. 21 , ( 2 )
J NH, Venkataraman A, Thiruvengadam K, B B, M K, S S, Balaji S, S E et al. ( 2024 ) . Evaluation of platelet indices as markers of tuberculosis among children in India . ERJ Open Research vol. 10 , ( 1 ) 00734 - 02023 .
Hayes R, Dakin F, Smuk M, Paparini S, Apea V, Dewsnap C, Waters L, Anderson J et al. ( 2024 ) . Cross-sectional survey of sexual health professionals’ experiences and perceptions of the 2022 mpox outbreak in the UK . BMJ Open vol. 14 , ( 1 )
Slade M, Rennick‐Egglestone S, Elliott RA, Newby C, Robinson C, Gavan SP, Paterson L, Ali Y et al. ( 2024 ) . Effectiveness and cost‐effectiveness of online recorded recovery narratives in improving quality of life for people with non‐psychotic mental health problems: a pragmatic randomized controlled trial . World Psychiatry vol. 23 , ( 1 ) 101 - 112 .
Sohanpal R, Pinnock H, Steed L, Heslop-Marshall K, Kelly MJ, Chan C, Wileman V, Barradell A et al. ( 2024 ) . A tailored psychological intervention for anxiety and depression management in people with chronic obstructive pulmonary disease: TANDEM RCT and process evaluation . Health Technology Assessment vol. 28 , ( 1 ) 1 - 129 .
Bourke C, Robertson R ( 2023 ) . Severe acute malnutrition promotes bacterial binding over pro-inflammatory cytokine secretion by circulating innate immune cells . Science Advances vol. 9 , ( 44 ) Article eadh2284 ,
Phiri TN, Mutasa K, Rukobo S, Govha M, Mushayanembwa P, Mwakamui S, Haider T, Zyambo K et al. ( 2023 ) . Severe acute malnutrition promotes bacterial binding over proinflammatory cytokine secretion by circulating innate immune cells . Science Advances vol. 9 , ( 44 ) eadh2284 - eadh2284 .
Wan YI, Smuk M, Pearse RM, Paparini S, Apea VJ, Orkin CM ( 2023 ) . Clinical research in the NHS: a cross-sectional study of research engagement during the monkeypox pandemic . BMJ Leader vol. 7 , ( Suppl 2 )
Hosang GM, Havers L, Shuai R, Fonagy P, Fazel M, Morgan C, Karamanos A, Fancourt D et al. ( 2023 ) . Protocol for secondary data analysis of 4 UK cohorts examining youth adversity and mental health in the context of intersectionality . PLOS ONE vol. 18 , ( 8 )
Taylor SJC, Sohanpal R, Steed L, Marshall K, Chan C, Yaziji N, Barradell AC, Font-Gilabert P et al. ( 2023 ) . Tailored psychological intervention for anxiety or depression in COPD (TANDEM): a randomised controlled trial . European Respiratory Journal vol. 62 , ( 5 ) 2300432 - 2300432 .
Orkin C, Paparini S, Thornhill JP, Apea V, Mwendera CA, Smuk M, Hayes R, Anderson J et al. ( 2023 ) . SHARING to create knowledge in a crisis . BMJ Leader vol. 7 , ( Suppl 2 )
Piper JD, Mazhanga C, Mwapaura M, Mapako G, Mapurisa I, Mashedze T, Munyama E, Kuona M et al. ( 2023 ) . The Sanitation Hygiene Infant Nutrition Efficacy (SHINE) Trial: Protocol for school-age follow-up . Wellcome Open Research vol. 8 ,
Piper JD, Mazhanga C, Mwapaura M, Mapako G, Mapurisa I, Mashedze T, Munyama E, Kuona M et al. ( 2023 ) . The Sanitation Hygiene Infant Nutrition Efficacy (SHINE) Trial: Protocol for school-age follow-up . Wellcome open research vol. 8 ,
James M, Rahman N, Smuk M, Alazawi W ( 2023 ) . SAT-512 A systematic review and meta-analysis of the prevalence and cross-sectional severity of South Asian patients with non-alcoholic fatty liver disease . Journal of Hepatology vol. 78 , s726 - s727 .
Sheikh J, Allotey J, Kew T, Fernández-Félix BM, Zamora J, Khalil A, Thangaratinam S, Network IC et al. ( 2022 ) . Effects of race and ethnicity on perinatal outcomes in high-income and upper-middle-income countries: an individual participant data meta-analysis of 2 198 655 pregnancies . The Lancet vol. 400 , ( 10368 ) 2049 - 2062 .
Paparini S, Whitacre R, Smuk M, Thornhill J, Mwendera C, Strachan S, Nutland W, Orkin C ( 2022 ) . Public understanding and awareness of and response to monkeypox virus outbreak: A cross‐sectional survey of the most affected communities in the United Kingdom during the 2022 public health emergency . HIV Medicine vol. 24 , ( 5 ) 544 - 557 .
Piper JD, Mazhanga C, Mapako G, Mapurisa I, Mashedze T, Munyama E, Mwapaura M, Chidhanguro D et al. ( 2022 ) . Piloting the adaptation of the Kaufman Assessment Battery for Children—2nd edition (KABC-II) to assess school-age neurodevelopment in rural Zimbabwe . Wellcome Open Research vol. 7 ,
Venkataraman A, Shanmugam S, Balaji S, Mani K, Shanmugavel AK, Muthuramalingam K, Hissar S, Thiruvengadam K et al. ( 2022 ) . Comparison of two mycobacterial strains in performance of the whole blood mycobacterial growth inhibition assay in Indian children . Tuberculosis vol. 137 ,
Allotey J, Whittle R, Snell KIE, Smuk M, Townsend R, von Dadelszen P, Magee L, Smith GCS et al. ( 2022 ) . External validation of prognostic models to predict stillbirth using International Prediction of Pregnancy Complications (IPPIC) Network database: individual participant data meta‐analysis . Ultrasound in Obstetrics and Gynecology vol. 59 , ( 2 ) 209 - 219 .
Fowler A, Wahedally M, ABBOTT T, Smuk M, Prowle J, Pearse R, Cromwell D ( 2021 ) . Death following surgery among patients with long-term disease: Prospective study of routinely collected data in the English NHS . British Journal of Anaesthesia
Priebe S, Fung C, Brusco LI, Carbonetti F, Gomez-Restrepo C, Uribe M, Diez-Canseco F, Smuk M et al. ( 2021 ) . Which resources help young people to prevent and overcome mental distress in deprived urban areas in Latin America? A protocol for a prospective cohort study . BMJ Open
Smith NR, Marshall L, Albakri M, Smuk M, Hagell A ( 2021 ) . Adolescent mental health difficulties and educational attainment: findings from the UK household longitudinal study . BMJ Open vol. 11 , ( 7 )
Slade M, Rennick-Egglestone S, Llewellyn-Beardsley J, Yeo C, Roe J, Bailey S, Smith RA, Booth S et al. ( 2021 ) . Recorded Mental Health Recovery Narratives as a Resource for People Affected by Mental Health Problems: Development of the Narrative Experiences Online (NEON) Intervention . JMIR Formative Research vol. 5 , ( 5 )
Stansfeld S, Clark C, Smuk M, Babisch W ( 2021 ) . Road traffic noise, noise sensitivity, noise annoyance, psychological and physical health and mortality . Environmental Health vol. 20 , ( 1 )
Carpenter JR ( 2021 ) . Missing data: A statistical framework for practice . Biometrical Journal vol. 63 , ( 5 ) 915 - 947 .
Gordeev VS, Akuze J, Baschieri A, Thysen SM, Dzabeng F, Haider MM, Smuk M, Wild M et al. ( 2021 ) . Paradata analyses to inform population-based survey capture of pregnancy outcomes: EN-INDEPTH study . Population Health Metrics vol. 19 , ( Suppl 1 )
Allotey J, Laivuori H, Snell KI, Smuk M, Hooper R, Chan CL, Ahmed A, Chappell LC et al. ( 2020 ) . Validation and development of models using clinical, biochemical and ultrasound markers for predicting pre-eclampsia: an individual participant data meta-analysis . Health Technology Assessment vol. 24 , ( 72 ) 1 - 252 .
Snell KIE, Allotey J, Smuk M, Hooper R, Chan C, Ahmed A, Chappell LC, Von Dadelszen P et al. ( 2020 ) . External validation of prognostic models predicting pre-eclampsia: individual participant data meta-analysis . BMC Medicine vol. 18 , ( 1 )
Chan CL, Smuk M, Sohanpal R, Pinnock H, Taylor SJC ( 2020 ) . Tailored, psychological intervention for anxiety and/or depression in people with chronic obstructive pulmonary disease (COPD), TANDEM (Tailored intervention for ANxiety and DEpression Management in COPD): statistical analysis plan for a randomised controlled trial . Trials vol. 21 , ( 1 )
Rennick-Egglestone S, Elliott R, Smuk M, Robinson C, Bailey S, Smith R, Keppens J, Hussain H et al. ( 2020 ) . Impact of receiving recorded mental health recovery narratives on quality of life in people experiencing psychosis, people experiencing other mental health problems and for informal carers: Narrative Experiences Online (NEON) study protocol for three randomised controlled trials . Trials vol. 21 , ( 1 )
Stansfeld S, Clark C, Gallacher J ( 2020 ) . Road traffic noise, noise sensitivity, psychological and physical health and mortality .
Sohanpal R, Pinnock H, Steed L, Heslop Marshall K, Chan C, Kelly M, Priebe S, Roberts CM et al. ( 2020 ) . Tailored, psychological intervention for anxiety or depression in people with chronic obstructive pulmonary disease (COPD), TANDEM (Tailored intervention for ANxiety and DEpression Management in COPD): protocol for a randomised controlled trial . Trials vol. 21 , ( 1 )
ELDRIDGE SM ( 2018 ) . The effects of the London 2012 Olympics and related urban regeneration on physical and mental health: the ORiEL mixed-methods evaluation of a natural experiment . Public Health Res
Stansfeld SA, Carr E, Smuk M, Clark C, Murray E ( 2018 ) . Mid-life psychosocial work environment as a predictor of work exit by age 50 . PLoS One vol. 13 , ( 4 ) e0195495 - e0195495 .
Eagan ME, Clark C, Evans GW ( 2018 ) . Assessing aircraft noise conditions affecting classroom behaviors . Inter Noise 2018 47th International Congress and Exposition on Noise Control Engineering Impact of Noise Control Engineering .
Clark C, Smuk M, Lain D, Stansfeld S ( 2017 ) . THE IMPACT OF LIFE-COURSE PSYCHOLOGICAL HEALTH ON LABOUR FORCE PARTICIPATION AND EXIT IN LATER LIFE . Innovation in Aging vol. 1 , ( suppl_1 ) 278 - 278 .
Rahtz E, BHUI KS, Smuk M ( 2017 ) . Violent injury predicts poor psychololgical outcomes after traumatic injury in a hard to reach population: an observational cohort study . BMJ Open
Fahy AE, Stansfeld SA, Smuk M, Lain D, Clark C ( 2017 ) . Longitudinal associations of experiences of adversity and socioeconomic disadvantage during childhood with labour force participation and exit in later adulthood . Social Science & Medicine vol. 183 , 80 - 87 .
Smuk M, Carpenter JR ( 2017 ) . Erratum to: What impact do assumptions about missing data have on conclusions? a practical sensitivity analysis for a cancer survival registry . BMC Med Res Methodol vol. 17 , ( 1 ) 51 - 51 .
Smuk M, Carpenter JR ( 2017 ) . What impact do assumptions about missing data have on conclusions? A practical sensitivity analysis for a cancer survival registry . BMC Medical Research Methodology vol. 17 , ( 1 )
Clark C, Smuk M, Lain D, van der Horst M ( 2016 ) . The impact of childhood psychological health on labour force participation in later life . EUROPEAN JOURNAL OF PUBLIC HEALTH . Conference: Internoise vol. 26 , 159 - 159 .
STANSFELD SA, Clark C, smuk M, davidson T ( 2016 ) . Childhood Adversity and midlife suicidal ideation . Psychological Medicine
Ajaz A, David R, Brown D, Korszun A ( 2016 ) . BASH: badmouthing, attitudes and stigmatisation in healthcare as experienced by medical students . BJPsych Bull vol. 40 , ( 2 ) 97 - 102 .
Smith NR, Clark C, Smuk M, Cummins S ( 2015 ) . The influence of social support on ethnic differences in well-being and depression in adolescents: findings from the prospective Olympic Regeneration in East London (ORiEL) study . Social Psychiatry and Psychiatric Epidemiology vol. 50 , ( 11 ) 1701 - 1711 .
Stansfeld SA, Kerry S, Chandola T, Russell J, Berney L, Hounsome N, Lanz D, Costelloe C et al. ( 2015 ) . Pilot study of a cluster randomised trial of a guided e-learning health promotion intervention for managers based on management standards for the improvement of employee well-being and reduction of sickness absence: GEM Study . BMJ Open vol. 5 , ( 10 )
Smith NR, Clark C, Smuk M ( 2015 ) . The influence of social support on ethnic differences in well-being and depression in adolescents: findings from the prospective Olympic Regeneration in East London (ORiEL) study . Social Psychiatry and Psychiatric Epidemiology vol. 50 , ( 11 ) 1701 - 1711 .
Stansfeld S, Smuk M, Onwumere J, Clark C, Pike C, McManus S ( 2014 ) . Stressors and common mental disorder in informal carers--an analysis of the English Adult Psychiatric Morbidity Survey 2007 . Soc Sci Med vol. 120 , 190 - 198 .
Clark C, Smuk M, Stansfeld S, Notley H ( 2014 ) . What factors are associated with noise sensitivity in the UK population? . Internoise 2014 43rd International Congress on Noise Control Engineering Improving the World Through Noise Control .
Carpenter R, McGarvey C, Mitchell EA, Tappin DM, Vennemann MM ( 2013 ) . Bed sharing when parents do not smoke: is there a risk of SIDS? An individual level analysis of five major case-control studies . BMJ Open vol. 3 , ( 5 )
Havers L, Bhui K, Shuai R, Fonagy P, Fazel M, Morgan C, Fancourt D, McCrone P et al. . A cross-sectional investigation into the role of intersectionality as a moderator of the relation between youth adversity and adolescent depression/anxiety symptoms in the community .
Clark C, Smuk M, Cummins S, Eldridge S, Fahy A, Lewis D, Moore DG, Smith N et al. . An Olympic Legacy? Does the urban regeneration associated with the London 2012 Olympic Games impact on adolescent mental health? . American Journal of Epidemiology
Wan YI, Smuk M, Pearse RM, Paparini S, Apea VJ, Orkin CM . Clinical academics in the NHS: a cross-section study of research engagement during the monkeypox pandemic .
Clark LV, Buckland M, Murphy G, Taylor N, Vleck V, Mein C, Wozniak E, Smuk M et al. . Cytokine responses to exercise and activity in patients with chronic fatigue syndrome: case control study . Clinical and Experimental Immunology
Mathur S, Smuk M, Evans C, Wedderburn CJ, Gibb DM, Penazzato M, Prendergast AJ . Estimating the Impact of Alternative Programmatic Cotrimoxazole Strategies on Mortality Among Children Born to Mothers with HIV: A Modelling Study .
Piper JD, Mazhanga C, Mwapaura M, Mapako G, Mapurisa I, Mashedze T, Munyama E, Kuona M et al. . Growth, physical and cognitive function in children who are born HIV-free: school-age follow-up of a cluster-randomized trial in rural Zimbabwe .
Apea V, Titanji BK, Dakin FH, Hayes R, Smuk M, Kawu H, Waters L, Levy I et al. . International healthcare workers’ experiences and perceptions of the 2022 multi-country mpox outbreak .
Havers L, Fazel M, Smuk M, Fancourt D, Fonagy P, McCrone P, Pavarini G, Bhui K et al. . Intersectional inequalities in childhood maltreatment and adolescent emotional problems: a MAIHDA analysis of a large community sample in England .
FAHY AE, Stansfeld SA, Smuk M, Smith NR, Cummins S, Clark C . Longitudinal associations between cyberbullying involvement and adolescent mental health . Journal of Adolescent Health
Orkin C, Ring K, Smuk M . Multicentre service evaluation of injectable cabotegravir and rilpivirine delivery and outcomes across 12 UK clinics (SHARE LAI-net) . HIV Medicine
Hosang GM, Havers L, Shuai R, Fonagy P, Fazel M, Morgan C, Karamanos A, Fancourt D et al. . Protocol for secondary data analysis of 4 UK cohorts examining youth adversity and mental health in the context of intersectionality .
Paparini S, Whitacre R, Smuk M, Thornhill J, Mwendera C, Strachan S, Nutland W, Orkin C . Public understanding, awareness, and response to monkeypox virus outbreak: A cross-sectional survey of the most affected communities in the United Kingdom during the 2022 public health emergency .
Slade M, Rennick-Egglestone S, Llewellyn-Beardsley J, Yeo C, Roe J, Bailey S, Smith RA, Booth S et al. . Recorded Mental Health Recovery Narratives as a Resource for People Affected by Mental Health Problems: Development of the Narrative Experiences Online (NEON) Intervention (Preprint) .
Stansfeld S, Clark C, Smuk M, Gallacher J, Babisch W . Road Traffic Noise, Noise Sensitivity, Noise Annoyance, Psychological and Physical Health and Mortality .
Piper JD, Mazhanga C, Mwapaura M, Mapako G, Mapurisa I, Mashedze T, Munyama E, Kuona M et al. . The Sanitation Hygiene Infant Nutrition Efficacy (SHINE) Trial: Protocol for School-Age Follow-up .
CLARK C, Smuk M, Lain D, Stansfeld SA, Carr E, Head J, Vickerstaff S . The impact of childhood and adulthood psychological health on labour force participation and exit in later life . Psychological Medicine
Havers L, Shuai R, Fonagy P, Fazel M, Craig M, Fancourt D, McCrone P, Smuk M et al. . Youth adversity and trajectories of depression and anxiety symptoms in adolescence in the context of intersectionality .