Publications: PROF Tony Michael

Michael AE ( 2023 ) . Steroid Hormones and Prostaglandins . Part 1 MRCOG Synoptic Revision Guide , Cambridge University Press (CUP)

Michael AE, Thurston LM, Fowkes RC ( 2019 ) . Hormonal Regulation of Glucocorticoid Inactivation and Reactivation in αT3-1 and LβT2 Gonadotroph Cells . Biology vol. 8 , ( 4 )

Hannen R, Udeh-Momoh C, Upton J, Wright M, Michael A, Gulati A, Rajpopat S, Clayton N et al. ( 2017 ) . Dysfunctional Skin-Derived Glucocorticoid Synthesis Is a Pathogenic Mechanism of Psoriasis . Journal of Investigative Dermatology vol. 137 , ( 8 ) 1630 - 1637 .

Michael AE, Glenn C, Wood PJ, Webb RJ, Pellatt L, Mason HD ( 2013 ) . Ovarian 11β-Hydroxysteroid Dehydrogenase (11βHSD) Activity Is Suppressed in Women With Anovulatory Polycystic Ovary Syndrome (PCOS): Apparent Role for Ovarian Androgens . The Journal of Clinical Endocrinology & Metabolism vol. 98 , ( 8 ) 3375 - 3383 .

Cabrera-Sharp V, Mirczuk SM, Shervill E, Michael AE, Fowkes RC ( 2013 ) . Regulation of glucocorticoid metabolism in the boar testis and caput epididymidis by the gonadotrophin-cAMP signalling pathway . Cell and Tissue Research vol. 352 , ( 3 ) 751 - 760 .

Glister C, Satchell L, Michael AE, Bicknell AB, Knight PG ( 2012 ) . The Anti-Epileptic Drug Valproic Acid (VPA) Inhibits Steroidogenesis in Bovine Theca and Granulosa Cells In Vitro . PLOS ONE vol. 7 , ( 11 )

Mukherjee S, James JL, Thilaganathan B, Whitley, Michael AE, Cartwright JE ( 2011 ) . Elevated glucocorticoid metabolism in placental tissue from first trimester pregnancies at increased risk of pre-eclampsia . Placenta vol. 32 , ( 9 ) 687 - 693 .

Hannen RF, Michael AE, Jaulim A, Bhogal R, Burrin JM, Philpott MP ( 2010 ) . Steroid synthesis by primary human keratinocytes; implications for skin disease . Biochemical and Biophysical Research Communications vol. 404 , ( 1 ) 62 - 67 .

Webley GE, Michael AE, Abayasekara DRE ( 2010 ) . The relationship between the production and the anti-gonadotrophic action of prostaglandin F2α in luteal cells from the marmoset monkey (Callithrix jacchus) in the early and mid-luteal phase . General and Comparative Endocrinology vol. 166 , ( 2 ) 436 - 442 .

Sharp V, Thurston LM, Fowkes RC, Michael AE ( 2009 ) . Expression and activities of 11βHSD enzymes in the testes and reproductive tracts of sexually immature male pigs . The Journal of Steroid Biochemistry and Molecular Biology vol. 115 , ( 3-5 ) 98 - 106 .

Webb RJ, Sunak N, Wren L, Michael AE ( 2008 ) . Inactivation of glucocorticoids by 11β-hydroxysteroid dehydrogenase enzymes increases during the meiotic maturation of porcine oocytes . Reproduction vol. 136 , ( 6 ) 725 - 732 .

Michael AE, Papageorghiou AT ( 2008 ) . Potential significance of physiological and pharmacological glucocorticoids in early pregnancy . Human Reproduction Update vol. 14 , ( 5 ) 497 - 517 .

Hannen RF, Michael AE, Burrin J, Philpott MP ( 2008 ) . StAR role for glucocorticoid synthesis in keratinocytes . BRITISH JOURNAL OF DERMATOLOGY . vol. 158 , 881 - 881 .

Hannen RF, Michael AE, Burrin JM, Philpott M ( 2007 ) . Human skin and keratinocytes express cholesterol transporters and primary keratinocytes are capable of metabolising progesterone into cortisol . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 127 , S60 - S60 .

Sharp V, Thurston LM, Fowkes RC, Michael AE ( 2007 ) . 11β-Hydroxysteroid dehydrogenase enzymes in the testis and male reproductive tract of the boar (Sus scrofa domestica) indicate local roles for glucocorticoids in male reproductive physiology . Reproduction vol. 134 , ( 3 ) 473 - 482 .

Chandras C, Harris TE, Bernal AL, Abayasekara DRE, Michael AE ( 2007 ) . PTGER1 and PTGER2 receptors mediate regulation of progesterone synthesis and type 1 11β-hydroxysteroid dehydrogenase activity by prostaglandin E2 in human granulosa–lutein cells . Journal of Endocrinology vol. 194 , ( 3 ) 595 - 602 .

Sunak N, Green DF, Abeydeera LR, Thurston LM, Michael AE ( 2007 ) . Implication of cortisol and 11β-hydroxysteroid dehydrogenase enzymes in the development of porcine (Sus scrofa domestica) ovarian follicles and cysts . Reproduction vol. 133 , ( 6 ) 1149 - 1158 .

Thurston LM, Abayasekara DRE, Michael AE ( 2007 ) . 11β-Hydroxysteroid dehydrogenase expression and activities in bovine granulosa cells and corpora lutea implicate corticosteroids in bovine ovarian physiology . Journal of Endocrinology vol. 193 , ( 2 ) 299 - 310 .

Jonas KC, Chandras C, Abayasekara DRE, Michael AE ( 2006 ) . Role for Prostaglandins in the Regulation of Type 1 11β-Hydroxysteroid Dehydrogenase in Human Granulosa-Lutein Cells . Endocrinology vol. 147 , ( 12 ) 5865 - 5872 .

Chandras C, Ragoobir J, Barrett GE, Bruckdorfer KR, Graham A, Abayasekara DRE, Michael AE ( 2004 ) . Roles for prostaglandins in the steroidogenic response of human granulosa cells to high-density lipoproteins . Molecular and Cellular Endocrinology vol. 222 , ( 1-2 ) 1 - 8 .

McMullen S, Osgerby JC, Thurston LM, Gadd TS, Wood PJ, Wathes DC, Michael AE ( 2004 ) . Alterations in placental 11β-hydroxysteroid dehydrogenase (11βHSD) activities and fetal cortisol:cortisone ratios induced by nutritional restriction prior to conception and at defined stages of gestation in ewes . Reproduction vol. 127 , ( 6 ) 717 - 725 .

Michael AE, Thurston LM, Rae MT ( 2003 ) . Glucocorticoid metabolism and reproduction: a tale of two enzymes . Reproduction vol. 126 , ( 4 ) 425 - 441 .

Thurston LM, Norgate DP, Jonas KC, Gregory L, Wood PJ, Cooke BA, Michael AE ( 2003 ) . Ovarian modulators of type 1 11β‐hydroxysteroid dehydrogenase (11βHSD) activity and intra‐follicular cortisol:cortisone ratios correlate with the clinical outcome of IVF . Human Reproduction vol. 18 , ( 8 ) 1603 - 1612 .

Thurston LM, Chin E, Jonas KC, Bujalska IJ, Stewart PM, Abayasekara DRE, Michael AE ( 2003 ) . Expression of 11beta-hydroxysteroid dehydrogenase (11betaHSD) proteins in luteinizing human granulosa-lutein cells . Journal of Endocrinology vol. 178 , ( 1 ) 127 - 135 .

Michael AE, Collins TD, Norgate DP, Gregory L, Wood PJ, Cooke BA ( 2003 ) . Relationship between ovarian cortisol:cortisone ratios and the clinical outcome of in vitro fertilization and embryo transfer (IVF‐ET) . Clinical Endocrinology vol. 51 , ( 5 ) 535 - 540 .

Thurston LM, Jonas KC, Abayasekara DRE, Michael AE ( 2003 ) . Ovarian Modulators of 11β-Hydroxysteroid Dehydrogenase (11βHSD) Activity in Follicular Fluid from Bovine and Porcine Large Antral Follicles and Spontaneous Ovarian Cysts1 . Biology of Reproduction vol. 68 , ( 6 ) 2157 - 2163 .

Yoong WC, Tuck SM, Michael AE ( 2003 ) . Binding of ovarian steroids to erythrocytes in patients with sickle cell disease; effects on cell sickling and osmotic fragility . The Journal of Steroid Biochemistry and Molecular Biology vol. 84 , ( 1 ) 71 - 78 .

Michael AE ( 2003 ) . Life after liquorice: the link between cortisol and conception . Reproductive BioMedicine Online vol. 7 , ( 6 ) 683 - 690 .

Thurston LM, Norgate DP, Jonas KC, Chandras C, Kloosterboer HJ, Cooke BA, Michael AE ( 2002 ) . Ovarian modulators of 11beta-hydroxysteroid dehydrogenase (11betaHSD) activity in follicular fluid from gonadotrophin-stimulated assisted conception cycles . Reproduction vol. 124 , ( 6 ) 801 - 812 .

Ragoobir J, Abayasekara DRE, Bruckdorfer KR, Michael AE ( 2002 ) . Stimulation of progesterone production in human granulosa-lutein cells by lipoproteins: evidence for cholesterol-independent actions of high-density lipoproteins . Journal of Endocrinology vol. 173 , ( 1 ) 103 - 111 .

MICHAEL ( 2002 ) . 11βHSD and the mechanism of gossypol‐induced hypokalemia . International Journal of Andrology vol. 21 , ( 5 ) 313 - 313 .

Fowkes RC, Chandras C, Chin EC, Okolo S, Abayasekara DR, Michael AE ( 2001 ) . Relationship between the production of prostaglandins and progesterone by luteinizing human granulosa cells . Journal of Endocrinology vol. 171 , ( 3 ) 455 - 462 .

Harris TE, Squires PE, Michael AE, Bernal AL, Abayasekara DR ( 2001 ) . Human Granulosa-Lutein Cells Express Functional EP1 and EP2 Prostaglandin Receptors . Biochemical and Biophysical Research Communications vol. 285 , ( 5 ) 1089 - 1094 .

Thompson A, Bailey MA, Michael AE, Unwin RJ ( 2000 ) . Effects of Changes in Dietary Intake of Sodium and Potassium and of Metabolic Acidosis on 11β-Hydroxysteroid Dehydrogenase Activities in Rat Kidney . Experimental Nephrology vol. 8 , ( 1 ) 44 - 51 .

Ferguson SE, Pallikaros Z, Michael AE, Cooke BA ( 1999 ) . The effects of different culture media, glucose, pyridine nucleotides and adenosine on the activity of 11β-hydroxysteroid dehydrogenase in rat Leydig cells . Molecular and Cellular Endocrinology vol. 158 , ( 1-2 ) 37 - 44 .

SEWELL KJ, SHIRLEY DG, MICHAEL AE, THOMPSON A, NORGATE DP, UNWIN RJ ( 1998 ) . Inhibition of renal 11β-hydroxysteroid dehydrogenase in vivo by carbenoxolone in the rat and its relationship to sodium excretion . Clinical Science vol. 95 , ( 4 ) 435 - 443 .

Michael AE, Evagelatou M, Norgate DP, Clarke RJ, Antoniw JW, Stedman BA, Brennan A, Welsby R et al. ( 1997 ) . Isoforms of 11β-hydroxysteroid dehydrogenase in human granulosa-lutein cells . Molecular and Cellular Endocrinology vol. 132 , ( 1-2 ) 43 - 52 .

Ramnath HI, Peterson S, Michael AE, Stocco DM, Cooke BA ( 1997 ) . Modulation of Steroidogenesis by Chloride Ions in MA-10 Mouse Tumor Leydig Cells: Roles of Calcium, Protein Synthesis, and the Steroidogenic Acute Regulatory Protein . Endocrinology vol. 138 , ( 6 ) 2308 - 2314 .

Michael AE, Gregory L, Thaventhiran L, Antoniw JW, Cooke BA ( 1996 ) . Follicular variation in ovarian 11β-hydroxysteroid dehydrogenase (11βHSD) activities: evidence for the paracrine inhibition of 11βHSD in human granulosa-lutein cells . Journal of Endocrinology vol. 148 , ( 3 ) 419 - 425 .

Pallikaros Z, Schulster D, Baldwin SA, Helliwell RJA, Michael AE, Cooke BA ( 1995 ) . Characterization of site-directed antibodies to the LH receptor in functionally active gonadal cells and their differential effects on LH-stimulated signal transduction in Leydig tumour (MA10) cells . Molecular and Cellular Endocrinology vol. 114 , ( 1-2 ) 57 - 68 .

Michael AE, Gregory L, Piercy EC, Walker SM, Shaw RW, Cooke BA ( 1995 ) . Ovarian 11β-hydroxysteroid dehydrogenase activity is inversely related to the outcome of in vitro fertilization-embryo transfer treatment cycles**The use of 11β-hydroxysteroid dehydrogenase measurements to predict the outcome of IVF-ET in all species is governed under International Patent Application PCT/GB94/00596.††Supported by grant C3/91 from Wellbeing (formerly Birthright; London, United Kingdom) and by grants from the Stanley Thomas Johnson Foundation (Berne, Switzerland) . Fertility and Sterility vol. 64 , ( 3 ) 590 - 598 .

Michael AE, Cooke BA ( 1994 ) . A working hypothesis for the regulation of steroidogenesis and germ cell development in the gonads by glucocorticoids and 11β-hydroxysteroid dehydrogenase (11βHSD) . Molecular and Cellular Endocrinology vol. 100 , ( 1-2 ) 55 - 63 .

Michael AE, Abayasekara DRE, Webley GE ( 1994 ) . Cellular mechanisms of luteolysis . Molecular and Cellular Endocrinology vol. 99 , ( 1 ) r1 - r9 .

Abayasekara DRE, Michael AE, Webley GE, Flint APF ( 1993 ) . Mode of action of prostaglandin F2α in human luteinized granulosa cells: role of protein kinase C . Molecular and Cellular Endocrinology vol. 97 , ( 1-2 ) 81 - 91 .

Michael AE, Antoniw JW, Cooke BA, Gregory L, Walker SM, Shaw RW, Edwards CRW ( 1993 ) . Ovarian 11β-hydroxysteroid dehydrogenase: potential predictor of conception by in-vitro fertilisation and embryo transfer . The Lancet vol. 342 , ( 8873 ) 711 - 712 .

Michael AE, Abayasekara DR, Webley GE ( 1993 ) . The luteotrophic actions of prostaglandins E2 and F2α on dispersed marmoset luteal cells are differentially mediated via cyclic AMP and protein kinase C . Journal of Endocrinology vol. 138 , ( 2 ) 291 - 298 .

Michael AE, Webley GE ( 1993 ) . Roles of cyclic AMP and inositol phosphates in the luteolytic action of cloprostenol, a prostaglandin F2α analogue, in marmoset monkeys (Callithrix jacchus) . J Reprod Fertil vol. 97 , ( 2 ) 425 - 431 .

Abayasekara DRE, Jones PM, Persaud SJ, Michael AE, Flint APF ( 1993 ) . Prostaglandin F2α activates protein kinase C in human ovarian cells . Molecular and Cellular Endocrinology vol. 91 , ( 1-2 ) 51 - 57 .

Michael AE, Webley GE ( 1991 ) . Prostaglandin F2α stimulates cAMP phosphodiesterase via protein kinase C in cultured human granulosa cells . Molecular and Cellular Endocrinology vol. 82 , ( 2-3 ) 207 - 214 .

Michael AE, Webley GE ( 1991 ) . Prior exposure to gonadotrophins prevents the subsequent antigonadotrophic actions of cloprostenol by a cyclic AMP-dependent mechanism in cultured human granulosa cells . Journal of Endocrinology vol. 131 , ( 2 ) 319 - 325 .