Publications: DR Oliver Pearce

Castro NM, Nolan J, Maniati E, Agrawal A, Gauthier V, Pearce OMT, Verbruggen SW, Knight MM ( 2025 ) . Multi-omics qualification of an organ-on-a-chip model of osteolytic bone metastasis . Acta Biomaterialia vol. 209 , 362 - 374 .

Tarantola L, Keklikoglou I, Pearce OM ( 2024 ) . Abstract C045: The extracellular matrix glycoprotein periostin supports chemotherapy resistance by modulating macrophage recruitment and phagocytosis in triple negative breast cancer . Cancer Research vol. 84 , ( 22_Supplement ) c045 - c045 .

Ramos MB, Tyler E, Soulier A, Davies M, Maher J, Sahai E, Correa de Sampaio P, Pearce O ( 2024 ) . 1374 ECM degrading bacteria boost CAR T cell therapy in solid cancers . Conference: Regular and Young Investigator Award Abstractsa1537 - a1537 .

Correa de Sampaio P, Soulier A, Ramos MB, Pearce O, Panagi M, Stylianopoulos T ( 2024 ) . 1379 Enabling checkpoint inhibitor efficacy in solid tumours through engineered live biotherapeutics . Conference: Regular and Young Investigator Award Abstractsa1542 - a1542 .

Tyler EJ ( 2024 ) . Tumor's Digest: Macrophage Metabolism Creates a Barrier to T Cells . Cancer Research vol. 84 , ( 20 ) 3322 - 3323 .

Hirani P, McDermott J, Rajeeve V, Cutillas PR, Jones JL, Pennington DJ, Wight TN, Santamaria S et al. ( 2024 ) . Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate . Cancer Research Communications vol. 4 , ( 4 ) 970 - 985 .

Liu Y, Okesola BO, de la Peña DO, Li W, Lin M, Trabulo S, Tatari M, Lawlor RT et al. ( 2024 ) . A Self‐Assembled 3D Model Demonstrates How Stiffness Educates Tumor Cell Phenotypes and Therapy Resistance in Pancreatic Cancer . Advanced Healthcare Materials vol. 13 , ( 17 )

Verbruggen SW, Nolan J, Duffy MP, Pearce OMT, Jacobs CR, Knight MM ( 2023 ) . A Novel Primary Cilium‐Mediated Mechanism Through which Osteocytes Regulate Metastatic Behavior of Both Breast and Prostate Cancer Cells . Advanced Science vol. 11 , ( 2 )

Carter EP, Yoneten KK, Gavara N, Tyler EJ, Gauthier V, Murray ER, Dijke PT, Cameron AJ et al. ( 2023 ) . Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function . The Journal of Pathology vol. 262 , ( 1 ) 90 - 104 .

Carter E, Yoneten K, Gavara N, Tyler E, Gauthier V, Murray E, Dijke PT, Cameron A et al. ( 2023 ) . Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function . Pancreatology vol. 23 , ( 4 ) e13 - e14 .

Puttock EH, Tyler EJ, Manni M, Maniati E, Butterworth C, Burger Ramos M, Peerani E, Hirani P et al. ( 2023 ) . Extracellular matrix educates an immunoregulatory tumor macrophage phenotype found in ovarian cancer metastasis . Nature Communications vol. 14 , ( 1 )

Gauthier V, Tyler E, Sharp TV ( 2023 ) . Abstract 1339: Targeting specific extracellular matrix proteins to reactivate T cell trafficking in triple-negative breast cancer . Cancer Research vol. 83 , ( 7_Supplement ) 1339 - 1339 .

Hirani P, Alonge KM, Pennington DJ, Cutillas PR, Wight TN, Pearce OM ( 2023 ) . Abstract 5841: Exploring the role of versican in immune exclusion within triple negative breast cancer . Cancer Research vol. 83 , ( 7_Supplement ) 5841 - 5841 .

Nolan J, Pearce OMT, Screen HRC, Knight MM, Verbruggen SW ( 2023 ) . Organ-on-a-Chip and Microfluidic Platforms for Oncology in the UK . Cancers vol. 15 , ( 3 )

Meng H, Fu S, Ferreira MB, Hou Y, Pearce OM, Gavara N, Knight MM ( 2022 ) . YAP activation inhibits inflammatory signalling and cartilage breakdown associated with reduced primary cilia expression . Osteoarthritis and Cartilage vol. 31 , ( 5 ) 600 - 612 .

Stanczak MA, Rodrigues Mantuano N, Kirchhammer N, Sanin DE, Jacob F, Coelho R, Everest-Dass AV, Wang J et al. ( 2022 ) . Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade . Science Translational Medicine vol. 14 , ( 669 ) eabj1270 - eabj1270 .

Beatson R, Läubli H ( 2022 ) . Editorial: Glycans: Masters of immunity, from cancers to inflammatory disease . Frontiers in Immunology vol. 13 ,

Sarmin AM, Moussaid NE, Suntornnond R, Tyler EJ, Kim Y-H, Di Cio S, Megone WV ( 2022 ) . Multi-Scale Analysis of the Composition, Structure, and Function of Decellularized Extracellular Matrix for Human Skin and Wound Healing Models . Biomolecules vol. 12 , ( 6 )

Murray ER, Menezes S, Henry JC, Williams JL, Alba-Castellón L, Baskaran P, Quétier I, Desai A et al. ( 2022 ) . Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion . Cell Reports vol. 38 , ( 4 )

Malacrida B, Balkwill FR ( 2022 ) . Building in vitro 3D human multicellular models of high-grade serous ovarian cancer . STAR Protocols vol. 3 , ( 1 )

Lecker LSM, Berlato C, Maniati E, Delaine-Smith R, Pearce OMT, Heath O, Nichols SJ, Trevisan C et al. ( 2021 ) . TGFBI Production by Macrophages Contributes to an Immunosuppressive Microenvironment in Ovarian CancerTGFBI and Ovarian Cancer . Cancer Research vol. 81 , ( 22 ) 5706 - 5719 .

Hirani P, Gauthier V, Allen CE ( 2021 ) . Targeting Versican as a Potential Immunotherapeutic Strategy in the Treatment of Cancer . Frontiers in Oncology vol. 11 ,

Malacrida B, Delaine-Smith R, Nichols S, Maniati E, Jones RL, Knight MM, Pearce OM, Balkwill FR ( 2021 ) . Abstract 2642: Using 3-Dimensional in vitro models to unravel the complexity of the metastatic microenvironment in high-grade serous ovarian cancer . Cancer Research . vol. 81 , 2642 - 2642 .

Verbruggen SW, Thompson CL, Duffy MP, Lunetto S, Nolan J, Pearce OMT, Jacobs CR, Knight MM ( 2021 ) . Mechanical Stimulation Modulates Osteocyte Regulation of Cancer Cell Phenotype . Cancers vol. 13 , ( 12 )

Malacrida B, Nichols S, Maniati E, Jones R, Delanie-Smith R, Roozitalab R, Tyler EJ, Thomas M et al. ( 2021 ) . A human multi-cellular model shows how platelets drive production of diseased extracellular matrix and tissue invasion . iScience vol. 24 , ( 6 )

Delaine-Smith RM, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones RR, Lecker LSM, Pearce OMT et al. ( 2021 ) . Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer . iScience vol. 24 , ( 6 )

Delaine-Smith RM, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones RR, Lecker L, Pearce OMT et al. ( 2021 ) . Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer .

Reuten R, Zendehroud S, Nicolau M, Fleischhauer L, Laitala A, Kiderlen S, Nikodemus D, Wullkopf L et al. ( 2021 ) . Basement membrane stiffness determines metastases formation . Nature Materials vol. 20 , ( 6 ) 892 - 903 .

Pearce OMT, Läubli H ( 2020 ) . A Sweet Approach to Heat Up Cancer Response to Immunotherapy . Cancer Discovery vol. 10 , ( 12 ) 1789 - 1790 .

Zaghdoudi S, Decaup E, Belhabib I, Samain R, Cassant-Sourdy S, Rochotte J, Brunel A, Schlaepfer D et al. ( 2020 ) . FAK activity in cancer-associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer . EMBO MOLECULAR MEDICINE vol. 12 , ( 11 ) Article ARTN e12010 ,

Zaghdoudi S, Decaup E, Belhabib I, Samain R, Cassant‐Sourdy S, Rochotte J, Schlaepfer D, Cros J et al. ( 2020 ) . FAK activity in cancer‐associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer . EMBO Molecular Medicine vol. 12 , ( 11 )

Wight TN, Kang I, Evanko SP, Harten IA, Chang MY, Pearce OMT, Allen CE, Frevert CW ( 2020 ) . Versican—A Critical Extracellular Matrix Regulator of Immunity and Inflammation . Frontiers in Immunology vol. 11 ,

Maniati E, Berlato C, Gopinathan G, Heath O, Kotantaki P, Lakhani A, McDermott J, Pegrum C et al. ( 2020 ) . Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment . Cell Reports vol. 30 , ( 2 ) 525 - 540.e7 .

Maniati E, Berlato C, Gopinathan G, Heath O, Kotantaki P, Lakhani A, McDermott J, Pegrum C et al. ( 2019 ) . Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment .

Lecker LS, Trevisan C, Delaine-Smith R, Maniati E, Pearce O, Meinert C, Iwanicki M, Drapkin R et al. ( 2018 ) . Abstract A31: Mutant p53 increases integrin-ECM interactions in early HGSOC . Clinical Cancer Research . vol. 24 , a31 - a31 .

Pearce OMT ( 2018 ) . Cancer Immunotherapy . Glycobiology vol. 28 , ( 9 ) 638 - 639 .

Pearce OMT ( 2018 ) . Cancer glycan epitopes: biosynthesis, structure and function . Glycobiology vol. 28 , ( 9 ) 670 - 696 .

Pearce OMT, Delaine-Smith RM, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D et al. ( 2018 ) . Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers . Cancer Discovery vol. 8 , ( 3 )

Pearce OMT, Nichols S, Delaine-Smith R, Jones RR, Maniati E, Rootizalab R, Mackerodt J, Knight MM et al. ( 2018 ) . Investigating drivers of the tumour matrisome, and their role in disease progression . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 99 , A49 - A49 .

Puttock E, Rastrick J, White A ( 2018 ) . Investigating the tumour ECM in the inhibition of anti-tumour immunity . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 99 , A58 - A59 .

Bergfeld AK, Lawrence R, Diaz SL, Pearce OMT, Ghaderi D, Gagneux P, Leakey MG, Varki A ( 2017 ) . N-glycolyl groups of nonhuman chondroitin sulfates survive in ancient fossils . Proceedings of the National Academy of Sciences of the United States of America vol. 114 , ( 39 ) e8155 - e8164 .

Naba A, Pearce OMT, Del Rosario A, Ma D, Ding H, Rajeeve V, Cutillas PR, Balkwill FR et al. ( 2017 ) . Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics . Journal of Proteome Research vol. 16 , ( 8 ) 3083 - 3091 .

Balkwill FR, Pearce OM, Delaine-Smith R, Maniati E, Nichols S, Wang J, Bessant C, Knight M ( 2017 ) . Abstract 5558: Deconstruction of a human tumor microenvironment . Cancer Research . vol. 77 , 5558 - 5558 .

Montfort A, Pearce O, Maniati E, Vincent BG, Bixby L, Böhm S, Dowe T, Wilkes EH et al. ( 2017 ) . A Strong B-cell Response Is Part of the Immune Landscape in Human High-Grade Serous Ovarian Metastases . Clinical Cancer Research vol. 23 , ( 1 ) 250 - 262 .

Böhm S, Montfort A, Pearce OMT, Topping J, Chakravarty P, Everitt GLA, Clear A, McDermott JR et al. ( 2016 ) . Neoadjuvant Chemotherapy Modulates the Immune Microenvironment in Metastases of Tubo-Ovarian High-Grade Serous Carcinoma . Clinical Cancer Research vol. 22 , ( 12 ) 3025 - 3036 .

Pearce OMT, Läubli H ( 2015 ) . Sialic acids in cancer biology and immunity . Glycobiology vol. 26 , ( 2 ) 111 - 128 .

Gopinathan G, Milagre C, Pearce OMT, Reynolds LE, Hodivala-Dilke K, Leinster DA ( 2015 ) . Interleukin-6 Stimulates Defective Angiogenesis . Cancer Research vol. 75 , ( 15 ) 3098 - 3107 .

Gopinathan G, Milagre C, Pearce OMT, Reynolds L, Hodivala-Dilke K, Zhong H, Hollingsworth RE ( 2015 ) . Abstract 4162: Interleukin–6 stimulates defective angiogenesis . Cancer Research vol. 75 , ( 15_Supplement ) 4162 - 4162 .

Schwarz F, Pearce OM, Wang X, Samraj AN, Läubli H, Garcia JO, Fu X, Heyser C et al. ( 2015 ) . Siglec receptors impact mammalian lifespan by modulating oxidative stress . eLife vol. 4 ,

Sumida M, Hane M, Yabe U, Shimoda Y, Pearce OMT, Kiso M, Sawada M, Sato C ( 2015 ) . Rapid Trimming of Cell Surface Polysialic Acid (PolySia) by Exovesicular Sialidase Triggers Release of Preexisting Surface Neurotrophin* . Journal of Biological Chemistry vol. 290 , ( 21 ) 13202 - 13214 .

Pearce OMT, Samraj AN, Läubli H, Varki A ( 2015 ) . Reply to Mackenzie: A comparison of Neu5Gc and α-gal xenoantigens . Proceedings of the National Academy of Sciences of the United States of America vol. 112 , ( 12 ) e1405 - e1405 .

Samraj AN, Pearce OMT, Läubli H, Crittenden AN, Banda K, Bingman AE, Secrest P ( 2014 ) . A red meat-derived glycan promotes inflammation and cancer progression . Proceedings of the National Academy of Sciences of the United States of America vol. 112 , ( 2 ) 542 - 547 .

Pearce OMT, Läubli H, Verhagen A, Secrest P, Zhang J, Varki N ( 2014 ) . Abstract 1063: Inverse hormesis of cancer growth mediated by narrow ranges of tumor-directed antibodies . Cancer Research . vol. 74 , 1063 - 1063 .

Läubli H, Pearce OMT, Schwarz F, Deng L, Stanczak M, Verhagen A, Lusk C, Varki N et al. ( 2014 ) . Abstract 3659: Engagement of myelomonocytic siglecs by tumor-associated ligands modulates innate immune responses to cancer . Cancer Research . vol. 74 , 3659 - 3659 .

Samraj AN, Laubli H, Pearce O, Secrest P, Varki A ( 2014 ) . Abstract LB-156: A diet-derived sialic acid promotes inflammation and hepatocellular cancer . Cancer Research . vol. 74 ,

Läubli H, Pearce OMT, Schwarz F, Deng L, Stanczak MA, Deng L, Lusk C, Schwartz AG ( 2014 ) . Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer . Proceedings of the National Academy of Sciences of the United States of America vol. 111 , ( 39 ) 14211 - 14216 .

Pearce OM, Läubli H, Varki A ( 2014 ) . Hormesis in cancer immunology . OncoImmunology vol. 3 , ( 6 )

Pearce OMT, Läubli H, Verhagen A, Secrest P, Zhang J, Bui JD ( 2014 ) . Inverse hormesis of cancer growth mediated by narrow ranges of tumor-directed antibodies . Proceedings of the National Academy of Sciences of the United States of America vol. 111 , ( 16 ) 5998 - 6003 .

Bergfeld A, Lawrence R, Diaz S, Pearce O, van Vleet J, Esko J ( 2014 ) . Discovery of novel monosaccharides in animal glycans: natural occurrence of N‐glycolylhexosamines (607.6) . The FASEB Journal vol. 28 , ( S1 )

Buchlis G, Odorizzi P, Soto PC, Pearce OMT, Hui DJ, Jordan MS, Varki A ( 2013 ) . Enhanced T Cell Function in a Mouse Model of Human Glycosylation . The Journal of Immunology vol. 191 , ( 1 ) 228 - 237 .

Bergfeld AK, Pearce OMT, Diaz SL, Varki A ( 2012 ) . Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups ELUCIDATING THE INTRACELLULAR FATE OF THE NON-HUMAN SIALIC ACID N-GLYCOLYLNEURAMINIC ACID* . Journal of Biological Chemistry vol. 287 , ( 34 ) 28865 - 28881 .

Bergfeld AK, Pearce OMT, Diaz SL, Lawrence R, Vocadlo DJ, Choudhury B, Varki A ( 2012 ) . Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups INCORPORATION OF N-GLYCOLYLHEXOSAMINES INTO MAMMALIAN GLYCANS BY FEEDING N-GLYCOLYLGALACTOSAMINE* . Journal of Biological Chemistry vol. 287 , ( 34 ) 28898 - 28916 .

Davies LRL, Pearce OMT, Tessier MB, Assar S, Smutova V, Pajunen M, Sumida M, Kitajima K et al. ( 2012 ) . Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups RESISTANCE OF α2–8-LINKED N-GLYCOLYLNEURAMINIC ACID TO ENZYMATIC CLEAVAGE* . Journal of Biological Chemistry vol. 287 , ( 34 ) 28917 - 28931 .

Bergfeld AK, Pearce OMT, Diaz S, Pham T ( 2012 ) . Intracellular fate of the non‐human sialic acid N‐glycolylneuraminic acid . The FASEB Journal . vol. 26 , 793.1 - 793.1 .

Davies L, Pearce O, Tessier M, Assar S, Smutova V, Varki A ( 2012 ) . Unusual chemical and enzymatic stability of polysialic acid containing N‐glycolylneuraminic acid . The FASEB Journal vol. 26 , ( S1 ) 610.1 - 610.1 .

Bergfeld AK, Diaz SL, Lawrence R, Esko JD ( 2012 ) . Natural occurrence of <i>N</i>-glycolyl-hexosamines in chondroitin/dermatan sulfates in mammalian tissues, derived from the metabolism of <i>N</i>-glycolylneuraminic acid . GLYCOBIOLOGY . vol. 22 , 1539 - 1539 .

Buchlis G, Mingozzi F, Soto PC, Pearce O, Hui DJ ( 2010 ) . Intrinsically Hyperactive and Hyperproliferative CD8+ T Cells In Cmah-/- Mice as a Model of Human Gene Transfer Responses . Blood vol. 116 , ( 21 )

Pearce OMT ( 2010 ) . Chemo-enzymatic synthesis of the carbohydrate antigen N-glycolylneuraminic acid from glucose . Carbohydrate Research vol. 345 , ( 9 ) 1225 - 1229 .

Pearce OMT, Fisher KD, Humphries J, Seymour LW ( 2005 ) . Cover Picture: Glycoviruses: Chemical Glycosylation Retargets Adenoviral Gene Transfer (Angew. Chem. Int. Ed. 7/2005) . Angewandte Chemie International Edition vol. 44 , ( 7 ) 983 - 983 .

Pearce OMT, Fisher KD, Humphries J, Smith A ( 2005 ) . Glycoviruses: Chemical Glycosylation Retargets Adenoviral Gene Transfer . Angewandte Chemie International Edition vol. 44 , ( 7 ) 1057 - 1061 .

Pearce OMT, Fisher KD, Smith A ( 2005 ) . Titelbild: Glycoviruses: Chemical Glycosylation Retargets Adenoviral Gene Transfer (Angew. Chem. 7/2005) . Angewandte Chemie vol. 117 , ( 7 ) 1005 - 1005 .

Puttock EH, Tyler EJ, Manni M, Maniati E, Butterworth C, Peerani E, Hirani P, Gauthier V et al. . Extracellular matrix educates a tumor macrophage phenotype found in ovarian cancer metastasis .

Pearce O, Tyler E, Liu Y, Tarantola L, Maniati E, Thornton K, Gauthier V, Hirani P et al. . Glycosylated extracellular matrix drives immune suppression by controlling T cell movement, macrophage phenotype, and macrophage-T cell crosstalk in triple negative breast cancer .

Carter EP, Yoneten KK, Gavara N, Tyler EJ, Gauthier V, Murray ER, Cameron AJ, Pearce O et al. . Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function .

Stylianopoulos T, Panagi M, Mpekris F, Ramos MB, Voutouri C, Michael C, Pearce O, de Sampaio PC et al. . Programmable bacteria act as live biotherapeutics to remodel tumor stroma and potentiate immunotherapy .

Stanczak MA, Mantuano NR, Kirchhammer N, Sanin DE, Wang J, Trefny MP, Monaco G, Gray MA et al. . Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade .

. Targeting extracellular matrix deposition from tumour cells reactivates T cell infiltration and anti-PD1 response in immune-excluded triple-negative breast cancer .