Publications: P Angus Cameron

Calleja V, Henry JC, Cobbaut M, Sewell J, Rizzoti K, Houghton F, Boeing S, Anyanwu N et al. ( 2025 ) . The penetrant chordoid glioma PRKCA mutation is an oncogenic gain-of-function kinase inactivation eliciting early onset chondrosarcoma in mice .

Bolton CL, O'Sullivan R, Menezes S, Cameron AJ, Marin G, Marshall JF, Carter EP, Henkemeyer M et al. ( 2025 ) . Abstract 3859: Ephrin inhibition disrupts stromal-cancer crosstalk and reduces metastasis in pancreatic cancer . Cancer Research vol. 85 , ( 8_Supplement_1 ) 3859 - 3859 .

Henry JC, Cameron AJM ( 2025 ) . Cancer‐associated fibroblast heterogeneity in chordoma^† . The Journal of Pathology vol. 266 , ( 1 ) 5 - 8 .

zur Nedden S, Safari MS, Weber D, Kuenkel L, Garmsiri C, Lang L, Orset C, Freret T et al. ( 2024 ) . Protein kinase N1 deficiency results in upregulation of cerebral energy metabolism and is highly protective in in vivo and in vitro stroke models . Metabolism vol. 161 , Article 156039 , 156039 - 156039 .

Luna C, Eguíluz AG, Barrientos-Díez J, Moreno A, Guerra A, Esquer M, Seoane ML, Kay S et al. ( 2024 ) . Breadboarding the European Moon Rover System: discussion and results of the analogue field test campaign . 2024 International Conference on Space Robotics (iSpaRo) . Conference: 2024 International Conference on Space Robotics (iSpaRo) from: 24/06/2024 to: 27/06/2024 , 145 - 150 .

De Benedetti M, Kay S, Ocón J, Jalvo R, Cerezo ME, Gómez Eguíluz A, Alonso M, Fernandez JR et al. ( 2024 ) . RAPID & FASTNAV Projects: High-Speed Semi-Autonomous Rovers Enabling High Return Planetary Missions . 2024 International Conference on Space Robotics (iSpaRo) . Conference: 2024 International Conference on Space Robotics (iSpaRo) from: 24/06/2024 to: 27/06/2024 , 260 - 265 .

Jalil SMA, Henry JC, Cameron AJM ( 2024 ) . Targets in the Tumour Matrisome to Promote Cancer Therapy Response . Cancers vol. 16 , ( 10 ) 1847 - 1847 .

Carter EP, Yoneten KK, Gavara N, Tyler EJ, Gauthier V, Murray ER, ten Dijke P, Cameron AJ et al. ( 2023 ) . Opposing roles for <scp>ADAMTS2</scp> and <scp>ADAMTS14</scp> in myofibroblast differentiation and function . The Journal of Pathology vol. 262 , ( 1 ) 90 - 104 .

Rulten SL, Grose RP, Gatz SA, Jones JL, Cameron AJM ( 2023 ) . The Future of Precision Oncology . International Journal of Molecular Sciences vol. 24 , ( 16 ) 12613 - 12613 .

Okail MH, Kocher H, Cameron A ( 2023 ) . Investigating the Role of Protein Kinase N2 (PKN2) in Pancreatic Ductal Adenocarcinoma . Pancreatology vol. 23 , ( 4 ) e10 - e10 .

Carter E, Yoneten K, Gavara N, Tyler E, Gauthier V, Murray E, ten Dijke P, Cameron A et al. ( 2023 ) . Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function . Pancreatology vol. 23 , ( 4 ) e13 - e14 .

( 2023 ) . TGFβ-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progression . npj Breast Cancer vol. 9 , ( 1 ) Article 9 ,

Luna C, Barrientos-Díez J, Esquer M, Guerra A, López-Seoane M, Colmenarejo I, Gandía F, Kay S et al. ( 2023 ) . Modularity for lunar exploration: European Moon Rover System Pre-Phase A Design and Field Test Campaign Results . Proceedings of the International Astronautical Congress Iac . vol. 2023-October ,

Carter EP, Yoneten KK, Gavara N, Tyler EJ, Gauthier V, Murray ER, Cameron AJ, Pearce O et al. ( 2022 ) . Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function .

Marshall JJT, Cull JJ, Alharbi HO, Zaw Thin M, Cooper STE, Barrington C, Vanyai H, Snoeks T et al. ( 2022 ) . PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responses . Biochemical Journal vol. 479 , ( 13 ) 1467 - 1486 .

Menezes S, Okail MH, Jalil SMA, Kocher HM, Cameron AJM ( 2022 ) . Cancer‐associated fibroblasts in pancreatic cancer: new subtypes, new markers, new targets . The Journal of Pathology vol. 257 , ( 4 ) 526 - 544 .

Marshall JJT, Cull JJ, Alharbi HO, Thin MZ, Cooper STE, Barrington C, Vanyai H, Snoeks T et al. ( 2022 ) . PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responses .

Murray ER, Menezes S, Henry JC, Williams JL, Alba-Castellón L, Baskaran P, Quétier I, Desai A et al. ( 2022 ) . Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion . Cell Reports vol. 38 , ( 4 ) Article 110227 , 110227 - 110227 .

Colomba A, Claus J, Gao F, George R, Fornili A, Cameron AJM ( 2022 ) . Targeting the HER3 pseudokinase domain with small molecule inhibitors . 455 - 505 .

Hetmanski JHR, de Belly H, Busnelli I, Waring T, Nair RV, Sokleva V, Dobre O, Cameron A et al. ( 2019 ) . Membrane Tension Orchestrates Rear Retraction in Matrix-Directed Cell Migration . Developmental Cell vol. 51 , ( 4 ) 460 - 475.e10 .

Hetmanski JHR, de Belly H, Nair RV, Sokleva V, Dobre O, Cameron A, Gauthier N, Lamaze C et al. ( 2019 ) . Membrane tension orchestrates rear retraction in matrix directed cell migration . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 100 , A44 - A45 .

Tsui C, Martinez-Martin N, Gaya M, Maldonado P, Llorian M, Legrave NM, Rossi M, MacRae JI et al. ( 2018 ) . Protein Kinase C-β Dictates B Cell Fate by Regulating Mitochondrial Remodeling, Metabolic Reprogramming, and Heme Biosynthesis . Immunity vol. 48 , ( 6 ) 1144 - 1159.e5 .

Claus J, Patel G, Autore F, Colomba A, Weitsman G, Soliman TN, Roberts S, Zanetti-Domingues LC et al. ( 2018 ) . Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface . eLife vol. 7 , Article e32271 ,

Nedden SZ, Eith R, Schwarzer C, Zanetti L, Seitter H, Fresser F, Koschak A, Cameron AJM et al. ( 2018 ) . Protein kinase N1 critically regulates cerebellar development and long-term function . Journal of Clinical Investigation vol. 128 , ( 5 ) 2076 - 2088 .

Zur Nedden S, Orset C, Haellewyn B, Freret T, Fresser F, Eith R, Cameron AJM, Parker PJ et al. ( 2018 ) . ADORA2A-mediated protection of ischemia-reperfusion injury. Role of protein kinase N1: A new player in the pathophysiology of experimental stroke . PURINERGIC SIGNALLING . vol. 14 , S50 - S50 .

Murray ER, Cameron AJM ( 2017 ) . Towards specific inhibition of mTORC2 . Aging vol. 9 , ( 12 ) 2461 - 2462 .

Hurst CD, Alder O, Platt FM, Droop A, Stead LF, Burns JE, Burghel GJ, Jain S et al. ( 2017 ) . Genomic Subtypes of Non-invasive Bladder Cancer with Distinct Metabolic Profile and Female Gender Bias in KDM6A Mutation Frequency . Cancer Cell vol. 32 , ( 5 ) 701 - 715.e7 .

Cameron AJM, Veeriah S, Marshall JJT, Murray ER, Larijani B, Parker PJ ( 2017 ) . Uncoupling TORC2 from AGC kinases inhibits tumour growth . Oncotarget vol. 8 , ( 49 ) 84685 - 84696 .

Cenciarelli C, Marei HE, Felsani A, Casalbore P, Sica G, Puglisi MA, Cameron AJM, Olivi A et al. ( 2017 ) . Correction: PDGFRα depletion attenuates glioblastoma stem cells features by modulation of STAT3, RB1 and multiple oncogenic signals . Oncotarget vol. 8 , ( 22 ) 36931 - 36931 .

Hurst CD, Alder O, Platt FM, Droop A, Stead LF, Burns JE, Burghel GJ, Jain S et al. ( 2016 ) . Abstract LB-323: The genomic landscape of non-muscle-invasive bladder cancer: implications for molecular classification and treatment . Cancer Research vol. 76 , ( 14_Supplement )

Cenciarelli C, Marei HE, Felsani A, Casalbore P, Sica G, Puglisi MA, Cameron AJM, Olivi A et al. ( 2016 ) . PDGFRα depletion attenuates glioblastoma stem cells features by modulation of STAT3, RB1 and multiple oncogenic signals . Oncotarget vol. 7 , ( 33 ) 53047 - 53063 .

Quétier I, Marshall JJT, Spencer-Dene B, Lachmann S, Casamassima A, Franco C, Escuin S, Worrall JT et al. ( 2016 ) . Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion . Cell Reports vol. 14 , ( 3 ) 440 - 448 .

Martin-Liberal J, Cameron AJ, Claus J, Judson IR, Parker PJ, Linch M ( 2014 ) . Targeting protein kinase C in sarcoma . Biochimica et Biophysica Acta (BBA) - Reviews on Cancer vol. 1846 , ( 2 ) 547 - 559 .

Linch M, Riou P, Claus J, Cameron AJ, de Naurois J, Larijani B, Ng T, McDonald NQ et al. ( 2014 ) . Functional implications of assigned, assumed and assembled PKC structures . Biochemical Society Transactions vol. 42 , ( 1 ) 35 - 41 .

Linch M, Sanz-Garcia M, Rosse C, Riou P, Peel N, Madsen CD, Sahai E, Downward J et al. ( 2013 ) . Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids . Carcinogenesis vol. 35 , ( 2 ) 396 - 406 .

Linch M, Sanz-Garcia M, Soriano E, Zhang Y, Riou P, Rosse C, Cameron A, Knowles P et al. ( 2013 ) . A Cancer-Associated Mutation in Atypical Protein Kinase Cι Occurs in a Substrate-Specific Recruitment Motif . Science Signaling vol. 6 , ( 293 )

Claus J, Cameron AJM, Parker PJ ( 2013 ) . Pseudokinase drug intervention: a potentially poisoned chalice . Biochemical Society Transactions vol. 41 , ( 4 ) 1083 - 1088 .

Cameron AJM, Linch MD, Saurin AT, Escribano C, Parker PJ ( 2011 ) . mTORC2 targets AGC kinases through Sin1-dependent recruitment . Biochemical Journal vol. 439 , ( 2 ) 287 - 297 .

Cameron AJM ( 2011 ) . Occupational hazards: allosteric regulation of protein kinases through the nucleotide-binding pocket . Biochemical Society Transactions vol. 39 , ( 2 ) 472 - 476 .

Rosse C, Linch M, Kermorgant S, Cameron AJM, Boeckeler K, Parker PJ ( 2010 ) . PKC and the control of localized signal dynamics . NAT REV MOL CELL BIO vol. 11 , ( 2 ) 103 - 112 .

Cameron AJM, Parker PJ ( 2010 ) . Protein kinase C – A family of protein kinases, allosteric effectors or both? . Advances in Enzyme Regulation vol. 50 , ( 1 ) 169 - 177 .

Cameron AJM, Escribano C, Saurin AT, Kostelecky B, Parker PJ ( 2009 ) . PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity . Nature Structural &amp; Molecular Biology vol. 16 , ( 6 ) 624 - 630 .

Saurin AT, Durgan J, Cameron AJ, Faisal A, Marber MS, Parker PJ ( 2008 ) . The regulated assembly of a PKCɛ complex controls the completion of cytokinesis . Nature Cell Biology vol. 10 , ( 8 ) 891 - 901 .

Cameron AJ, Procyk KJ, Leitges M, Parker PJ ( 2008 ) . PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival . International Journal of Cancer vol. 123 , ( 4 ) 769 - 779 .

Durgan J, Cameron AJ, Saurin AT, Hanrahan S, Totty N, Messing RO, Parker PJ ( 2008 ) . The identification and characterization of novel PKCϵ phosphorylation sites provide evidence for functional cross-talk within the PKC superfamily . Biochemical Journal vol. 411 , ( 2 ) 319 - 331 .

Cameron AJ, De Rycker M, Calleja V, Alcor D, Kjaer S, Kostelecky B, Saurin A, Faisal A et al. ( 2007 ) . Protein kinases, from B to C . Biochemical Society Transactions vol. 35 , ( 5 ) 1013 - 1017 .

Hillyard DZ, Nutt CD, Thomson J, McDonald KJ, Wan RK, Cameron AJM, Mark PB, Jardine AG ( 2007 ) . Statins inhibit NK cell cytotoxicity by membrane raft depletion rather than inhibition of isoprenylation . Atherosclerosis vol. 191 , ( 2 ) 319 - 325 .

Cameron AJ, De Rycker M, Calleja V, Alcor D, Kjaer S, Kostelecky B, Saurin A, Faisal A et al. ( 2007 ) . Protein kinases, from B to C . Biochemical Society Transactions vol. 35 , ( 5 ) 1013 - 1017 .

HILLYARD D ( 2004 ) . Simvastatin inhibits lymphocyte function in normal subjects and patients with cardiovascular disease . Atherosclerosis vol. 175 , ( 2 ) 305 - 313 .

Hillyard D ( 2004 ) . Fluvastatin inhibits raft dependent Fcγ receptor signalling in human monocytes . Atherosclerosis vol. 172 , ( 2 ) 219 - 228 .

Cameron AJM, McDonald KJ, Harnett MM, Allen JM ( 2002 ) . Differentiation of the human monocyte cell line, U937, with dibutyryl cyclicAMP induces the expression of the inhibitory Fc receptor, FcγRIIb . Immunology Letters vol. 83 , ( 3 ) 171 - 179 .

Hillyard DZ, Cameron AJM, McIntyre AH, Hadden MH, Marshall HE, Johnston N, Jardine AG ( 2002 ) . Inhibition Of Proliferation And Signalling Mechanisms In Human Lymphocytes By Fluvastatin . Clinical and Experimental Pharmacology and Physiology vol. 29 , ( 8 ) 673 - 678 .

Hillyard DZ, Cameron AJM, MacIntyre A, Jardine AG ( 2002 ) . Mechanism of the Immunosuppressive Effects of Fluvastatin in Human Lymphocytes . Clinical Science vol. 102 , ( s46 ) 8P - 8P .

McDonald KJ, Cameron AJM, Allen JM, McLay JS, Jardine AG ( 2002 ) . A pathophysiological role for tubular Fc receptors in glomerulonephritis? . JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY vol. 13 , 175A - 175A .

McDonald KJ, Cameron AJM, Allen JM, Jardine AG ( 2002 ) . Expression of Fc α/μ Receptor by Human Mesangial Cells: A Candidate Receptor for Immune Complex Deposition in IgA Nephropathy . Biochemical and Biophysical Research Communications vol. 290 , ( 1 ) 438 - 442 .

Cameron, Allen ( 2001 ) . The human high‐affinity immunoglobulin G receptor activates SH2‐containing inositol phosphatase (SHIP) . Immunology vol. 97 , ( 4 ) 641 - 647 .

Cameron AJM, Harnett MM, Allen JM ( 2001 ) . Differential recruitment of accessory molecules by FcγRI during monocyte differentiation . European Journal of Immunology vol. 31 , ( 9 ) 2718 - 2725 .

CAMERON AJM, ALLEN JM ( 1999 ) . The human high affinity IgG receptor (FcγRI) induces the association of the 5′Inositol phosphatase, SHIP, with She in U937 cells . Biochemical Society Transactions vol. 27 , ( 3 ) A128 - A128 .

Melendez A, Floto RA, Cameron AJ, Gillooly DJ, Harnett MM, Allen JM ( 1998 ) . A molecular switch changes the signalling pathway used by the FcγRI antibody receptor to mobilise calcium . Current Biology vol. 8 , ( 4 ) 210 - 222 .

CAMERON AJM, ALLEN JM ( 1997 ) . Differential expression of the human high affinity IgG receptor FcγRI and associated signalling molecules in differentiated U937 monocyte cells . Biochemical Society Transactions vol. 25 , ( 3 ) 502S - 502S .

Leng J, Cameron AJ, Buckel S, Kennelly PJ ( 1995 ) . Isolation and cloning of a protein-serine/threonine phosphatase from an archaeon . Journal of Bacteriology vol. 177 , ( 22 ) 6510 - 6517 .

Hetmanski JHR, de Belly H, Nair RV, Sokleva V, Dobre O, Cameron A, Gauthier N, Lamaze C et al. . Membrane Tension Orchestrates Rear Retraction in Matrix Directed Cell Migration .