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  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: DR Gernot Walko

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Bojko J, Howard A, Lay E, Flynn B ( 2024 ) . 409 A non-transcriptional function of the oncoprotein YAP contributes to squamous cell carcinogenesis . Journal of Investigative Dermatology vol. 144 , ( 12 )
Jungwirth U ( 2024 ) . Boosting Skin Wound Healing by Agrin-Mediated YAP/TAZ Activation . Journal of Investigative Dermatology vol. 145 , ( 1 ) 6 - 8 .
Flynn B, Glallacher K ( 2024 ) . O16 Understanding the pleiotropic effects of the Rho-kinase inhibitor Y-27632 on human keratinocytes .
Kontou I, Pourzand C, Walko G ( 2024 ) . P04 How fibroblasts and azathioprine prepare the soil for cutaneous squamous cell carcinoma .
Lay E, Grant T ( 2024 ) . Generation of 3D Fibroblast-Derived Extracellular Matrix and Analysis of Tumor Cell-Matrix Interactions and Signaling . Imaging Cell Signaling , vol. 2800 , Springer Nature
Bojko J ( 2022 ) . 430 A non-transcriptional role of the oncoprotein YAP in cutaneous squamous cell carcinoma .
Howard A, Bojko J, Flynn B, Bowen S ( 2022 ) . Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers . Experimental Dermatology vol. 31 , ( 10 ) 1477 - 1499 .
Valencia RG, Mihailovska E, Winter L, Bauer K, Fischer I, Walko G, Zorec R ( 2020 ) . Plectin dysfunction in neurons leads to tau accumulation on microtubules affecting neuritogenesis, organelle trafficking, pain sensitivity and memory . Neuropathology and Applied Neurobiology vol. 47 , ( 1 ) 73 - 95 .
Walko G, Woodhouse S, Pisco AO, Rognoni E, Liakath-Ali K, Mishra A, Telerman S, Viswanathan P ( 2019 ) . 581 A genome-wide screen identifies YAP/WBP2/TEAD interplay conferring growth advantage on human epidermal stem cells . Journal of Investigative Dermatology . vol. 139 ,
Walko G, Lichtenberger B ( 2019 ) . A genome-wide screen identifies YAP/WBP2/TEAD interplay conferring growth advantage on human epidermal stem cells .
Negri VA, Logtenberg MEW, Renz LM, Oules B ( 2019 ) . Delta-like 1-mediated cis-inhibition of Jagged1/2 signalling inhibits differentiation of human epidermal cells in culture . Scientific Reports vol. 9 , ( 1 )
Rognoni E ( 2019 ) . The Roles of YAP/TAZ and the Hippo Pathway in Healthy and Diseased Skin . Cells vol. 8 , ( 5 ) 411 - 411 .
Mobasseri SA, Zijl S, Salameti V, Walko G, Stannard A ( 2019 ) . Patterning of human epidermal stem cells on undulating elastomer substrates reflects differences in cell stiffness . Acta Biomaterialia vol. 87 , 256 - 264 .
Zijl S, Vasilevich AS, Viswanathan P, Helling AL, Beijer NRM, Walko G, de Boer J ( 2018 ) . Micro-scaled topographies direct differentiation of human epidermal stem cells . Acta Biomaterialia vol. 84 , 133 - 145 .
Mishra A, Oulès B, Pisco AO, Ly T, Liakath-Ali K, Walko G, Viswanathan P, Nijjher J ( 2017 ) . A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis . eLife vol. 6 ,
Walko G, Woodhouse S, Pisco AO, Rognoni E, Liakath-Ali K, Lichtenberger BM, Mishra A, Telerman SB et al. ( 2017 ) . A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells . Nature Communications vol. 8 , ( 1 )
Osmanagic-Myers S, Rus S, Wolfram M, Brunner D, Goldmann WH, Bonakdar N, Zuzuarregui A ( 2015 ) . Plectin reinforces vascular integrity by mediating crosstalk between the vimentin and the actin networks . Development vol. 142 , ( 23 ) e1.1 - e1.1 .
Almeida FV, Walko G, McMillan JR, Wiche G, Barber AH ( 2015 ) . The cytolinker plectin regulates nuclear mechanotransduction in keratinocytes . Journal of Cell Science vol. 128 , ( 24 ) 4475 - 4486 .
Rezniczek GA, Winter L, Walko G ( 2015 ) . Chapter Thirteen Functional and Genetic Analysis of Plectin in Skin and Muscle . Methods in Enzymology vol. 569 , 235 - 259 .
Walko G, Castañón MJ, Wiche G ( 2015 ) . Molecular architecture and function of the hemidesmosome . Cell and Tissue Research vol. 360 , ( 3 ) 529 - 544 .
Osmanagic-Myers S, Rus S, Wolfram M, Brunner D, Goldmann WH, Bonakdar N, Fischer I, Wiche G ( 2015 ) . Plectin reinforces vascular integrity by mediating crosstalk between the vimentin and the actin networks . Journal of Cell Science vol. 128 , ( 22 ) 4138 - 4150 .
Walko G, Castañón MJ, Wiche G ( 2014 ) . Molecular architecture and function of the hemidesmosome . Cell and Tissue Research vol. 360 , ( 2 ) 363 - 378 .
Bonakdar N, Schilling A, Spörrer M, Lennert P, Mainka A, Wiche G, Fabry B ( 2014 ) . Determining the mechanical properties of plectin in mouse myoblasts and keratinocytes . Experimental Cell Research vol. 331 , ( 2 ) 331 - 337 .
Jungwirth U, Gojo J, Tuder T, Walko G, Holcmann M, Nowikovsky K, Wilfinger N, Kowol CR et al. ( 2014 ) . Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46 . Molecular Cancer Therapeutics vol. 13 , ( 10 ) 2436 - 2449 .
Gregor M, Osmanagic‐Myers S, Burgstaller G, Wolfram M, Fischer I, Walko G ( 2013 ) . Mechanosensing through focal adhesion‐anchored intermediate filaments . The FASEB Journal vol. 28 , ( 2 ) 715 - 729 .
Walko G, Wögenstein KL, Winter L, Fischer I ( 2013 ) . Stabilization of the dystroglycan complex in Cajal bands of myelinating Schwann cells through plectin‐mediated anchorage to vimentin filaments . Glia vol. 61 , ( 8 ) 1274 - 1287 .
Castañón MJ, Walko G, Winter L ( 2013 ) . Plectin–intermediate filament partnership in skin, skeletal muscle, and peripheral nerve . Histochemistry and Cell Biology vol. 140 , ( 1 ) 33 - 53 .
Valencia RG, Walko G, Janda L, Novacek J, Mihailovska E, Reipert S ( 2013 ) . Intermediate filament-associated cytolinker plectin 1c destabilizes microtubules in keratinocytes . Molecular Biology of the Cell vol. 24 , ( 6 ) 768 - 784 .
Walko G, Vukasinovic N, Gross K, Fischer I, Sibitz S, Fuchs P, Reipert S, Berger W et al. ( 2011 ) . Targeted Proteolysis of Plectin Isoform 1a Accounts for Hemidesmosome Dysfunction in Mice Mimicking the Dominant Skin Blistering Disease EBS-Ogna . PLOS Genetics vol. 7 , ( 12 )
Rezniczek GA, Wiche G ( 2010 ) . Plectin Gene Defects Lead to Various Forms of Epidermolysis Bullosa Simplex . Dermatologic Clinics vol. 28 , ( 1 ) 33 - 41 .
Fuchs P, Reipert S, Rezniczek GA, Propst F, Walko G, Fischer I, Bauer J, Lüscher B et al. ( 2009 ) . Targeted Inactivation of a Developmentally Regulated Neural Plectin Isoform (Plectin 1c) in Mice Leads to Reduced Motor Nerve Conduction Velocity* . Journal of Biological Chemistry vol. 284 , ( 39 ) 26502 - 26509 .
Kostan J, Gregor M, Wiche G ( 2009 ) . Plectin Isoform-dependent Regulation of Keratin-Integrin α6β4 Anchorage via Ca2+/Calmodulin* . Journal of Biological Chemistry vol. 284 , ( 27 ) 18525 - 18536 .
Ackerl R, Walko G, Fuchs P, Fischer I, Schmuth M ( 2007 ) . Conditional targeting of plectin in prenatal and adult mouse stratified epithelia causes keratinocyte fragility and lesional epidermal barrier defects . Journal of Cell Science vol. 120 , ( 14 ) 2435 - 2443 .
Osmanagic-Myers S, Gregor M, Walko G, Reipert S ( 2006 ) . Plectin-controlled keratin cytoarchitecture affects MAP kinases involved in cellular stress response and migration . Journal of Cell Biology vol. 174 , ( 4 ) 557 - 568 .
Hartmann R, Walko G ( 2001 ) . Inhibition of 2′‐5′ oligoadenylate synthetase by divalent metal ions . FEBS Letters vol. 507 , ( 1 ) 54 - 58 .
Mishra A, Pisco AO, Oules B, Ly T, Liakath-Ali K, Walko G, Viswanathan P, Nijjher J et al. . A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis .
Bojko J, Walko G . ESDR430 - A non-transcriptional role of the oncoprotein YAP in cutaneous squamous cell carcinoma .
Bojko J, Flynn B, Aschenbrenner B, Howard A, Lay E, Bailey E, Krajic N, Catalan S et al. . YAP engages RIF1 to dampen replication stress in squamous cell carcinoma .
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