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  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: DR Simon Mcarthur

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( 2025 ) . A standardised saffron extract improves subjective and objective sleep quality in healthy older adults with sleep complaints: results from the Gut-Sleep-Brain Axis randomised, double-blind, placebo-controlled pilot study .
( 2025 ) . A standardised saffron extract improves subjective and objective sleep quality in healthy older adults with sleep complaints: results from the gut-sleep-brain axis randomised, double-blind, placebo-controlled pilot study . Food & Function
( 2025 ) . Dietary substances and their glucuronides: structures, occurrence and biological activity . Natural Product Reports
Dalile B, Boyle NB, Ruiz FT, Chakrabarti A, Respondek F, Dodd GF, Kadosh KC, Hepsomali P et al. ( 2025 ) . Targeting Cognitive Resilience through Prebiotics: A Focused Perspective . Advances in Nutrition vol. 16 , ( 1 ) Article 100343 , 100343 - 100343 .
Shah SN, Knausenberger TB-A, Pontifex MG, Connell E, Le Gall G, Hardy TAJ, Randall DW, McCafferty K et al. ( 2024 ) . Cerebrovascular damage caused by the gut microbe/host co-metabolite\n <i>p</i>\n -cresol sulfate is prevented by blockade of the EGF receptor . Gut Microbes vol. 16 , ( 1 ) Article 2431651 ,
Connell E, Le Gall G, McArthur S, Lang L, Breeze B, Pontifex MG, Sami S, Pourtau L et al. ( 2024 ) . (Poly)phenol-rich grape and blueberry extract prevents LPS-induced disruption of the blood-brain barrier through the modulation of the gut microbiota-derived uremic toxins . Neurochemistry International vol. 180 , Article 105878 , 105878 - 105878 .
Maitre L, De Leeuw VC, Van Oostrom CT, Anguita A, Chatzi L, Coen M, Gražulevičienė R, Heude B et al. ( 2024 ) . Integrated Insights into Neurodevelopmental Effects of Trimethylamine N-Oxide (TMAO) and Trimethylamine (TMA): A Multi-Cohort Study Combining Epidemiology and Toxicology . ISEE Conference Abstracts vol. 2024 , ( 1 ) Article isee.2024.1045 ,
Láng L, McArthur S, Lazar AS, Pourtau L, Gaudout D, Pontifex MG, Müller M, Vauzour D ( 2024 ) . Dietary (Poly)phenols and the Gut–Brain Axis in Ageing . Nutrients vol. 16 , ( 10 ) 1500 - 1500 .
( 2024 ) . Circulatory dietary and gut-derived metabolites predict preclinical Alzheimer’s disease .
Wickstead ES, Elliott BT, Pokorny S, Biggs C, Getting SJ, McArthur S ( 2023 ) . Stimulation of the Pro-Resolving Receptor Fpr2 Reverses Inflammatory Microglial Activity by Suppressing NFκB Activity . International Journal of Molecular Sciences vol. 24 , ( 21 ) 15996 - 15996 .
McArthur S ( 2023 ) . The gut microbe‐derived methylamine TMAO protects against neuroinflammation through restraint of pro‐inflammatory glial behaviour . Alzheimer's &amp; Dementia vol. 19 , ( S1 ) Article e066817 ,
McArthur S ( 2023 ) . Regulation of Physiological Barrier Function by the Commensal Microbiota . Life vol. 13 , ( 2 ) 396 - 396 .
Wickstead ES, Solito E, McArthur S ( 2022 ) . Promiscuous Receptors and Neuroinflammation: The Formyl Peptide Class . Life vol. 12 , ( 12 ) 2009 - 2009 .
Shah SN, Knausenberger TB-A, Pontifex MG, Connell E, Le Gall G, Hardy TAJ, Randall DW, McCafferty K et al. ( 2022 ) . Cerebrovascular damage caused by the gut microbe/host co-metabolite<i>p</i>-cresol sulfate is prevented by blockade of the EGF receptor .
Stachulski AV, Knausenberger TB-A, Shah SN, Hoyles L, McArthur S ( 2022 ) . A host–gut microbial amino acid co-metabolite, <i>p</i>-cresol glucuronide, promotes blood–brain barrier integrity <i>in vivo</i> . Tissue Barriers vol. 11 , ( 1 ) Article 2073175 ,
( 2022 ) . A host–gut microbial co-metabolite of aromatic amino acids, <i>p</i>-cresol glucuronide, promotes blood–brain barrier integrity <i>in vivo</i> .
Sheikh MH, Errede M, d'Amati A, Khan NQ, Fanti S, Loiola RA, McArthur S, Purvis GSD et al. ( 2021 ) . Impact of metabolic disorders on the structural, functional, and immunological integrity of the blood‐brain barrier: Therapeutic avenues . The FASEB Journal vol. 36 , ( 1 )
Hoyles L, Pontifex MG, Rodriguez-Ramiro I, Anis-Alavi MA, Jelane KS, Snelling T, Solito E, Fonseca S et al. ( 2021 ) . Regulation of blood–brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide . Microbiome vol. 9 , ( 1 ) Article 235 ,
Adiutori R, Puentes F, Bremang M, Lombardi V, Zubiri I, Leoni E, Aarum J, Sheer D et al. ( 2021 ) . Analysis of circulating protein aggregates as a route of investigation into neurodegenerative disorders . Brain Communications vol. 3 , ( 3 ) Article fcab148 ,
Wickstead ES, Irving MA, Getting SJ, McArthur S ( 2021 ) . Exploiting formyl peptide receptor 2 to promote microglial resolution: a new approach to Alzheimer’s disease treatment . The FEBS Journal vol. 289 , ( 7 ) 1801 - 1822 .
( 2021 ) . Regulation of blood–brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine<i>N</i>-oxide .
Pearson JRD, Cuzzubbo S, McArthur S, Durrant LG, Adhikaree J, Tinsley CJ, Pockley AG, McArdle SEB ( 2020 ) . Immune Escape in Glioblastoma Multiforme and the Adaptation of Immunotherapies for Treatment . Frontiers in Immunology vol. 11 , Article 582106 ,
( 2020 ) . Analysis of Circulating Protein Aggregates Reveals Pathological Hallmarks of Amyotrophic Lateral Sclerosis .
( 2020 ) . Activation of the pro-resolving receptors Fpr2/3 attenuate lipopolysaccharide-induced inflammatory microglial activation .
Wickstead ES, Karim HA, Manuel RE, Biggs CS, Getting SJ, McArthur S ( 2020 ) . Reversal of <i>β</i>-Amyloid-Induced Microglial Toxicity <i>In Vitro</i> by Activation of Fpr2/3 . Oxidative Medicine and Cellular Longevity vol. 2020 , 1 - 13 .
Sheikh MH, Henson SM, Loiola RA, Mercurio S, Colamatteo A, Maniscalco GT, De Rosa V, McArthur S et al. ( 2020 ) . Immuno-metabolic impact of the multiple sclerosis patients’ sera on endothelial cells of the blood-brain barrier . Journal of Neuroinflammation vol. 17 , ( 1 ) Article 153 ,
( 2020 ) . Analysis of circulating protein aggregates reveals pathological hallmarks of amyotrophic lateral sclerosis .
( 2020 ) . Reversal of β-amyloid induced microglial toxicity<i>in vitro</i>by activation of Fpr2/3 .
( 2020 ) . Annexin A1 drives macrophage skewing to accelerate muscle regeneration through AMPK activation . Journal of Clinical Investigation vol. 130 , ( 3 ) 1156 - 1167 .
Wall J, Naganathar S, Praditsuktavorn B, Bugg OF, McArthur S, Thiemermann C, Tremoleda JL, Brohi K ( 2019 ) . RETRACTED: Modeling Cardiac Dysfunction Following Traumatic Hemorrhage Injury: Impact on Myocardial Integrity . Frontiers in Immunology vol. 10 , Article 2774 ,
( 2019 ) . Desmoglein-3 acts as a pro-survival protein by suppressing reactive oxygen species and doming whilst augmenting the tight junctions in MDCK cells . Mechanisms of Ageing and Development vol. 184 , Article 111174 , 111174 - 111174 .
Loiola RA, Wickstead ES, Solito E, McArthur S ( 2019 ) . Estrogen Promotes Pro-resolving Microglial Behavior and Phagocytic Cell Clearance Through the Actions of Annexin A1 . Frontiers in Endocrinology vol. 10 , Article 420 ,
Loiola RA, Wickstead ES, Solito E, McArthur S ( 2019 ) . Estrogen Promotes Pro-resolving Microglial Behavior and Phagocytic Cell Clearance Through the Actions of Annexin A1 . FRONTIERS IN ENDOCRINOLOGY vol. 10 , Article ARTN 420 ,
( 2018 ) . Estrogen promotes pro-resolving microglial behaviour and phagocytic cell clearance through the actions of annexin A1 .
Barrios-Silva LV, Parnell M, Shinwari ZB, Chaudhary GA, Xenofontos T, van Bekhoven A, McArthur S, Elliott BT ( 2018 ) . Activin subfamily peptides predict chronological age in humans . Physiological Reports vol. 6 , ( 17 ) e13823 - e13823 .
( 2018 ) . Annexin A1 drives macrophage skewing towards a resolving phenotype to accelerate the regeneration of muscle injury through AMPK activation .
Wickstead E, McArthur S ( 2018 ) . The Fpr2 agonist Quin-C1 stimulates inflammatory resolution in microglia; a role for metabolic homeostasis? .
Hoyles L, Snelling T, Umlai U-K, Nicholson JK, Carding SR, Glen RC, McArthur S ( 2018 ) . Microbiome–host systems interactions: protective effects of propionate upon the blood–brain barrier . Microbiome vol. 6 , ( 1 ) Article 55 ,
( 2017 ) . Microbiome–host systems interactions: Protective effects of propionate upon the blood–brain barrier .
( 2017 ) . Annexin A1 supplementation prevents the progression to fibrosis of nonalcoholic steatoepatitis (NASH) . Journal of Hepatology . vol. 66 , S608 - S608 .
McArthur S, Loiola RA, Maggioli E, Errede M, Virgintino D, Solito E ( 2016 ) . The restorative role of annexin A1 at the blood–brain barrier . Fluids and Barriers of the CNS vol. 13 , ( 1 ) Article 17 ,
Virdee K, Kentrop J, Jupp B, Venus B, Hensman D, McArthur S, Wilkinson J, Robbins TW et al. ( 2016 ) . Counteractive effects of antenatal glucocorticoid treatment on D1 receptor modulation of spatial working memory . Psychopharmacology vol. 233 , ( 21-22 ) 3751 - 3761 .
Maggioli E, McArthur S, Mauro C, Kieswich J, Kusters DHM, Reutelingsperger CPM, Yaqoob M, Solito E ( 2016 ) . Estrogen protects the blood–brain barrier from inflammation-induced disruption and increased lymphocyte trafficking . Brain, Behavior, and Immunity vol. 51 , 212 - 222 .
( 2015 ) . Definition of a Novel Pathway Centered on Lysophosphatidic Acid To Recruit Monocytes during the Resolution Phase of Tissue Inflammation . The Journal of Immunology vol. 195 , ( 3 ) 1139 - 1151 .
McArthur S, Pienaar IS, Siddiqi SM, Gillies GE ( 2015 ) . Sex-specific disruption of murine midbrain astrocytic and dopaminergic developmental trajectories following antenatal GC treatment . Brain Structure and Function vol. 221 , ( 5 ) 2459 - 2475 .
Shende VH, McArthur S, Gillies GE, Opacka-Juffry J ( 2015 ) . Astroglial Plasticity Is Implicated in Hippocampal Remodelling in Adult Rats Exposed to Antenatal Dexamethasone . Neural Plasticity vol. 2015 , 1 - 8 .
( 2014 ) . Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis . Proceedings of the National Academy of Sciences vol. 111 , ( 52 ) 18685 - 18690 .
( 2014 ) . Identification of a Novel Recycling Sequence in the C-tail of FPR2/ALX Receptor . Journal of Biological Chemistry vol. 289 , ( 52 ) 36166 - 36178 .
Gillies GE, Virdee K, McArthur S, Dalley JW ( 2014 ) . Sex-dependent diversity in ventral tegmental dopaminergic neurons and developmental programing: A molecular, cellular and behavioral analysis . Neuroscience vol. 282 , 69 - 85 .
( 2014 ) . Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice . Hepatology vol. 60 , ( 2 ) 531 - 544 .
Locatelli I, Sutti S, Jindal A, Vacchiano M, Bozzola C, Reutelingsperger C, Kusters D, Bena S et al. ( 2014 ) . P261 ROLE OF ANNEXIN A1 IN THE PROGRESSION OF NONALCOHOLIC STEATOHEPATITIS (NASH) . Journal of Hepatology . vol. 60 , S152 - S152 .
( 2013 ) . Ligand-specific conformational change of the G-protein–coupled receptor ALX/FPR2 determines proresolving functional responses . Proceedings of the National Academy of Sciences vol. 110 , ( 45 ) 18232 - 18237 .
( 2013 ) . Chemerin15 inhibits neutrophil‐mediated vascular inflammation and myocardial ischemia‐reperfusion injury through ChemR23 . EMBO reports vol. 14 , ( 11 ) 999 - 1007 .
Virdee K, McArthur S, Brischoux F, Caprioli D, Ungless MA, Robbins TW, Dalley JW, Gillies GE ( 2013 ) . Antenatal Glucocorticoid Treatment Induces Adaptations in Adult Midbrain Dopamine Neurons, which Underpin Sexually Dimorphic Behavioral Resilience . Neuropsychopharmacology vol. 39 , ( 2 ) 339 - 350 .
Nadkarni S, McArthur S ( 2013 ) . Oestrogen and immunomodulation: new mechanisms that impact on peripheral and central immunity . Current Opinion in Pharmacology vol. 13 , ( 4 ) 576 - 581 .
Katsouri L, Vizcaychipi MP, McArthur S, Harrison I, Suárez-Calvet M, Lleo A, Lloyd DG, Ma D et al. ( 2013 ) . Prazosin, an α1-adrenoceptor antagonist, prevents memory deterioration in the APP23 transgenic mouse model of Alzheimer's disease . Neurobiology of Aging vol. 34 , ( 4 ) 1105 - 1115 .
Cristante E, McArthur S, Mauro C, Maggioli E, Romero IA, Wylezinska-Arridge M, Couraud PO, Lopez-Tremoleda J et al. ( 2012 ) . Identification of an essential endogenous regulator of blood–brain barrier integrity, and its pathological and therapeutic implications . Proceedings of the National Academy of Sciences vol. 110 , ( 3 ) 832 - 841 .
( 2012 ) . Annexin A1 N-Terminal Derived Peptide Ac2-26 Exerts Chemokinetic Effects on Human Neutrophils . Frontiers in Pharmacology vol. 3 ,
McArthur S, Gillies GE ( 2011 ) . Peripheral vs. Central Sex Steroid Hormones in Experimental Parkinson?s Disease . Frontiers in Endocrinology vol. 2 ,
McArthur S, Robinson IC, Gillies GE ( 2010 ) . Novel Ontogenetic Patterns of Sexual Differentiation in Arcuate Nucleus GHRH Neurons Revealed in GHRH-Enhanced Green Fluorescent Protein Transgenic Mice . Endocrinology vol. 152 , ( 2 ) 607 - 617 .
McArthur S, Cristante E, Paterno M, Christian H, Roncaroli F, Gillies GE, Solito E ( 2010 ) . Annexin A1: A Central Player in the Anti-Inflammatory and Neuroprotective Role of Microglia . J IMMUNOL vol. 185 , ( 10 ) 6317 - 6328 .
Gillies GE, McArthur S ( 2010 ) . Estrogen Actions in the Brain and the Basis for Differential Action in Men and Women: A Case for Sex-Specific Medicines . Pharmacological Reviews vol. 62 , ( 2 ) 155 - 198 .
Yazid S, Ayoub SS, Solito E, McArthur S, Vo P, Dufton N, Flower RJ ( 2010 ) . Anti-allergic drugs and the Annexin-A1 system . PHARMACOL REP vol. 62 , ( 3 ) 511 - 517 .
Gillies GE, McArthur S ( 2010 ) . Independent influences of sex steroids of systemic and central origin in a rat model of Parkinson's disease: A contribution to sex-specific neuroprotection by estrogens . Hormones and Behavior vol. 57 , ( 1 ) 23 - 34 .
McArthur S, Yazid S, Christian H, Sirha R, Flower R, Buckingham J, Solito E ( 2009 ) . Annexin A1 regulates hormone exocytosis through a mechanism involving actin reorganization . FASEB J vol. 23 , ( 11 ) 4000 - 4010 .
Yazid S, Solito E, Christian H, McArthur S, Goulding N, Flower R ( 2009 ) . Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1 . BIOCHEM PHARMACOL vol. 77 , ( 12 ) 1814 - 1826 .
McArthur S, Prasongchean W, Gillies G, Solito E ( 2008 ) . A critical role for the anti-inflammatory protein annexin A1 in microglial phagocytosis . FUND CLIN PHARMACOL vol. 22 , 23 - 23 .
Solito E, McArthur S, Christian H, Gavins F, Buckingham JC, Gillies GE ( 2008 ) . Annexin A1 in the brain-undiscovered roles? . TRENDS PHARMACOL SCI vol. 29 , ( 3 ) 135 - 142 .
McArthur S, McHale E, Gillies GE ( 2006 ) . The Size and Distribution of Midbrain Dopaminergic Populations are Permanently Altered by Perinatal Glucocorticoid Exposure in a Sex- Region- and Time-Specific Manner . Neuropsychopharmacology vol. 32 , ( 7 ) 1462 - 1476 .
McArthur S, Murray HE, Dhankot A, Dexter DT, Gillies GE ( 2006 ) . Striatal susceptibility to a dopaminergic neurotoxin is independent of sex hormone effects on cell survival and DAT expression but is exacerbated by central aromatase inhibition . Journal of Neurochemistry vol. 100 , ( 3 ) 678 - 692 .
Gillies G, McArthur S, McHale E ( 2006 ) . Sex dimorphisms in the 3D cytoarchitecture of the adult VTA and permanent alterations by glucocorticoid exposure in late gestation . Frontiers in Neuroendocrinology vol. 27 , ( 1 ) 95 - 96 .
McArthur S, Siddique Z-L, Christian HC, Capone G, Theogaraj E, John CD, Smith SF, Morris JF et al. ( 2006 ) . Perinatal Glucocorticoid Treatment Disrupts the Hypothalamo-Lactotroph Axis in Adult Female, But Not Male, Rats . Endocrinology vol. 147 , ( 4 ) 1904 - 1915 .
McArthur S, McHale E, Dalley JW, Buckingham JC, Gillies GE ( 2005 ) . Altered Mesencephalic Dopaminergic Populations in Adulthood as a Consequence of Brief Perinatal Glucocorticoid Exposure . Journal of Neuroendocrinology vol. 17 , ( 8 ) 475 - 482 .
Gillies GE, Murray HE, Dexter D, McArthur S ( 2004 ) . Sex dimorphisms in the neuroprotective effects of estrogen in an animal model of Parkinson's disease . Pharmacology Biochemistry and Behavior vol. 78 , ( 3 ) 513 - 522 .
Murray HE, Pillai AV, McArthur SR, Razvi N, Datla KP, Dexter DT, Gillies GE ( 2003 ) . Dose- and sex-dependent effects of the neurotoxin 6-hydroxydopamine on the nigrostriatal dopaminergic pathway of adult rats: differential actions of estrogen in males and females . Neuroscience vol. 116 , ( 1 ) 213 - 222 .
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