Publications: PROF Andrew Tinker

Ackland GL, Hosford PS, Gutierrez del Arroyo A, Korsak A, Machhada A, Pickard J, Gomez De La Torre GG, Stuckey DJ et al. ( 2025 ) . Physiological Significance of Endothelial M3 Muscarinic Receptors During Exercise . Circulation Research vol. 137 , ( 5 ) 702 - 704 .

van Duijvenboden S, Ramírez J, Scheurink J, Darweesh SKL, Orini M, Tinker A, Munroe PB, Thannhauser J et al. ( 2025 ) . Heart Rate Profiles During Exercise and Incident Parkinson's Disease . Annals of Neurology Article ana.70010 ,

Ramírez J, van Duijvenboden S, Orini M, Lambiase PD, Tinker A, Young WJ, Munroe PB ( 2024 ) . Prediction of atrial and ventricular arrhythmias using multiple cardiovascular risk-factor polygenic risk scores . Heart Rhythm

van Duijvenboden S, Ramírez J, Scheurink J, Darweesh SKL, Orini M, Tinker A, Munroe PB, Thannhauser J et al. ( 2024 ) . Cardiac autonomic function during exercise and incident Parkinson’s disease .

Young W, Sanghvi MM, Ramirez J, Orini M, Tinker A, Warren HR, Lambiase PD, Munroe PB ( 2024 ) . Circulating metabolites associate with the QT interval in individuals without prevalent cardiovascular disease . European Heart Journal vol. 45 , ( Supplement_1 ) Article ehae666.2742 ,

Ramirez J, Martinez JP, Van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB et al. ( 2024 ) . Long-term time-to-ventricular arrhythmic event prediction using a deep learning based model on the electrocardiogram signal . European Heart Journal vol. 45 , ( Supplement_1 ) Article ehae666.3434 ,

Van Duijvenboden S, Nicholson G, Smith-Byrne K, Portas L, Atkins J, Ramirez J, Orini M, Young WJ et al. ( 2024 ) . The genetic architecture of exercise-induced ventricular ectopy . European Heart Journal vol. 45 , ( Supplement_1 ) Article ehae666.3668 ,

Young WJ, van der Most PJ, Bartz TM, Bos MM, Biino G, Duong T, Foco L, Lominchar JT et al. ( 2024 ) . Genome‐Wide Interaction Analyses of Serum Calcium on Ventricular Repolarization Time in 125 393 Participants . Journal of the American Heart Association vol. 13 , ( 17 ) Article e034760 ,

Vyas V, Sandhar B, Keane JM, Wood EG, Blythe H, Jones A, Shahaj E, Fanti S et al. ( 2024 ) . Tissue-resident memory T cells in epicardial adipose tissue comprise transcriptionally distinct subsets that are modulated in atrial fibrillation . Nature Cardiovascular Research vol. 3 , ( 9 ) 1067 - 1082 .

Ramírez J, van Duijvenboden S, Young WJ, Chen Y, Usman T, Orini M, Lambiase PD, Tinker A et al. ( 2024 ) . Fine mapping of candidate effector genes for heart rate . Human Genetics vol. 143 , ( 9-10 ) 1207 - 1221 .

Tsisanova E, Nobles M, Sebastian S, Ng K-E, Thomas A, Weinstein LS, Munroe PB, Tinker A ( 2024 ) . The ric-8b protein (resistance to inhibitors of cholinesterase 8b) is key to preserving contractile function in the adult heart . Journal of Biological Chemistry vol. 300 , ( 7 ) Article 107470 , 107470 - 107470 .

Brennan S, Chen S, Makwana S, Esposito S, McGuinness LR, Alnaimi AIM, Sims MW, Patel M et al. ( 2024 ) . Identification and characterisation of functional K_ir6.1‐containing ATP‐sensitive potassium channels in the cardiac ventricular sarcolemmal membrane . British Journal of Pharmacology vol. 181 , ( 18 ) 3380 - 3400 .

Kellett DO, Aziz Q, Humphries JD, Korsak A, Braga A, Gutierrez Del Arroyo A, Crescente M, Tinker A et al. ( 2024 ) . Transcriptional response of the heart to vagus nerve stimulation . Physiological Genomics vol. 56 , ( 2 ) 167 - 178 .

van Duijvenboden S, Ramírez J, Orini M, Aung N, Petersen SE, Doherty A, Tinker A, Munroe PB et al. ( 2023 ) . Prognostic Significance of Different Ventricular Ectopic Burdens During Submaximal Exercise in Asymptomatic UK Biobank Subjects . Circulation vol. 148 , ( 24 ) 1932 - 1944 .

Kellett DO, Aziz Q, Humphries JD, Korsak A, Braga A, Del Arroyo AG, Crescente M, Tinker A et al. ( 2023 ) . Transcriptional response of the heart to vagus nerve stimulation . Physiological genomics vol. 56 , ( 2 ) 167 - 178 .

Ramírez J, Miguel A, van Duijvenboden S, Orini M, J. Young W, Tinker A, Lambiase P, B. Munroe P et al. . A Multi-layer CNN Using the ECG, Age and Sex Predicts Ventricular Arrhythmias in the General Population . Computing in Cardiology Conference (CinC) . Conference: 2023 Computing in Cardiology Conference

Orini M, van Duijvenboden S, Ramírez J, Young W, Tinker A, Munroe P, Lambiase P . Ultra-Short Beat-to-Beat Repolarization Variability Predicts Cardiovascular Events in Individuals without Cardiovascular Disease . Computing in Cardiology Conference (CinC) . Conference: 2023 Computing in Cardiology Conference

Longhi P, Vyas V, Sandhar B, Wood E, Blythe H, Jones A, Shahaj E, Fanti S et al. ( 2023 ) . Tissue-resident memory T cells in Epicardial adipose tissue comprise transcriptionally distinct subsets that are modulated in Atrial Fibrillation .

Ramirez J, Martinez JP, Van Duijvenboden S, Tinker A, Lambiase P, Orini M, Munroe PB, Miguel A ( 2023 ) . Combining hypothesis-driven ECG indices with machine learning improves ventricular arrhythmic risk prediction in a low-risk population . European Heart Journal vol. 44 , ( Supplement_2 ) Article ehad655.2914 ,

Orini M, Van Duijvenboden S, Young WJ, Ramirez J, Jones AR, Tinker A, Munroe PB, Lambiase PD ( 2023 ) . Ultra-short heart rate variability over 15 seconds is associated with increased long-term risk of cardiovascular disease . European Heart Journal vol. 44 , ( Supplement_2 ) Article ehad655.2912 ,

Orini M, van Duijvenboden S, Young WJ, Ramírez J, Jones AR, Hughes AD, Tinker A, Munroe PB et al. ( 2023 ) . Long-term association of ultra-short heart rate variability with cardiovascular events . Scientific Reports vol. 13 , ( 1 ) Article 18966 ,

Ishida H, Saba R, Kokkinopoulos I, Hashimoto M, Yamaguchi O, Nowotschin S, Shiraishi M, Ruchaya P et al. ( 2023 ) . GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway . Cell Reports vol. 42 , ( 11 ) Article 113383 , 113383 - 113383 .

Sanpawithayakul K, Mistry A, Rai A, Funge G, Sebastian S, Solomou A, Lillina VM, Gaston-Massuet C et al. ( 2023 ) . Hindering the progression of cardiac fibrosis in acromegaly - the role of somatostatin receptor ligands . Endocrine Abstracts

Specterman MJ, Aziz Q, Li Y, Anderson NA, Ojake L, Ng K-E, Thomas AM, Finlay MC et al. ( 2023 ) . Hypoxia Promotes Atrial Tachyarrhythmias via Opening of ATP-Sensitive Potassium Channels . Circulation: Arrhythmia and Electrophysiology vol. 16 , ( 9 )

Williams JL, Smith CJ, Mastroianni G, Stewart M, Cutillas P, Tinker A, Metherell L ( 2023 ) . Abstract P2043: Loss Of Full-length Mylk3 Causes Dilated Cardiomyopathy Via A Myl2-independent Mechanism . Circulation Research vol. 133 , ( Suppl_1 )

Korsak A, Kellett DO, Aziz Q, Anderson C, D’Souza A, Tinker A, Ackland GL, Gourine AV ( 2023 ) . Immediate and sustained increases in the activity of vagal preganglionic neurons during exercise and after exercise training . Cardiovascular Research vol. 119 , ( 13 ) 2329 - 2341 .

Orini M, Duijvenboden SV, Young WJ, Ramírez J, Jones AR, Hughes A, Tinker A, Munroe PB et al. ( 2023 ) . Long-term association of 15-second heart rate variability with cardiovascular events .

Williams J, Stewart M, Tinker A, Cutillas P, Metherell L ( 2023 ) . BS18 Loss of full-length MYLK3 causes dilated cardiomyopathy via a MYL2-independent mechanism . Basic Science . Conference: British Cardiovascular Society Annual Conference, ‘Future-proofing Cardiology for the next 10 years’, 5–7 June 2023A258 - A259 .

Frost S, Parey E, Tinker A, Villar D ( 2023 ) . BS47 A comparative genomics approach reveals the interplay between epigenomic enhancer conservation and common genetic variation in the heart . Basic Science . Conference: British Cardiovascular Society Annual Conference, ‘Future-proofing Cardiology for the next 10 years’, 5–7 June 2023A279.2 - A279 .

Rodriguez A, Villar D, Frost S, Tinker A, Thomas A ( 2023 ) . BS56 An epigenomic investigation of atrial fibrillation in a paired left and right atrial cohort . Basic Science . Conference: British Cardiovascular Society Annual Conference, ‘Future-proofing Cardiology for the next 10 years’, 5–7 June 2023A285.1 - A285 .

Fernández-Aroca D, Frost S, Tikkas G, Rodriguez A, Tinker A, Villar D ( 2023 ) . BS69 Characterisation of in vivo and in vitro models for epigenomic investigations of cardiac hypertrophy . Basic Science . Conference: British Cardiovascular Society Annual Conference, ‘Future-proofing Cardiology for the next 10 years’, 5–7 June 2023A296.1 - A296 .

Zawada D, Kornherr J, Meier AB, Santamaria G, Dorn T, Nowak-Imialek M, Ortmann D, Zhang F et al. ( 2023 ) . Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools . Nature Communications vol. 14 , ( 1 ) Article 1722 ,

Young WJ, Haessler J, Benjamins J-W, Repetto L, Yao J, Isaacs A, Harper AR, Ramirez J et al. ( 2023 ) . Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease . Nature Communications vol. 14 , ( 1 ) Article 1411 ,

van Duijvenboden S, Ramírez J, Orini M, Doherty A, Tinker A, Munroe PB, Lambiase PD ( 2023 ) . Prognostic Significance of Different Ventricular Ectopic Burdens During Exercise in Asymptomatic UK Biobank Subjects .

Orini M, van Duijvenboden S, Young WJ, Ramírez J, Jones AR, Tinker A, Munroe PB, Lambiase PD ( 2023 ) . Premature atrial and ventricular contractions detected on wearable-format electrocardiograms and prediction of cardiovascular events . European Heart Journal - Digital Health vol. 4 , ( 2 ) 112 - 118 .

Orini M, van Duijvenboden S, Ramirez J, Tinker A, Munroe P, Lambiase\ P . Uncoupling Between Heart Rate Variability and Heart Rate During Exercise and Recovery as a Predictor of Cardiovascular Events . Computing in Cardiology Conference (CinC) . Conference: 2022 Computing in Cardiology Conference

Orini M, van Duijvenboden S, Tinker A, Munroe P, Lambiase\ P . \Association between photoplethysmography pulse upslope and cardiovascular events in over 170,000 UK Biobank participants\ . Computing in Cardiology Conference (CinC) . Conference: 2022 Computing in Cardiology Conference

Bercea C, Limbu R, Behnam K, Ng K-E, Aziz Q, Tinker A, Tamagnini F, Cottrell GS et al. ( 2022 ) . Omega-3 polyunsaturated fatty acid-induced vasodilation in mouse aorta and mesenteric arteries is not mediated by ATP-sensitive potassium channels . Frontiers in Physiology vol. 13 , Article 1033216 ,

Kwek X-Y, Hall AR, Lim W-W, Katwadi K, Soong PL, Grishina E, Lin K-H, Crespo-Avilan G et al. ( 2022 ) . Role of cardiac mitofusins in cardiac conduction following simulated ischemia–reperfusion . Scientific Reports vol. 12 , ( 1 ) Article 21049 ,

Morera C, Kim J, Paredes-Redondo A, Nobles M, Rybin D, Moccia R, Kowala A, Meng J et al. ( 2022 ) . CRISPR-mediated correction of skeletal muscle Ca2+ handling in a novel DMD patient-derived pluripotent stem cell model . Neuromuscular Disorders vol. 32 , ( 11-12 ) 908 - 922 .

Wilson D, Tinker A, Iskratsch T ( 2022 ) . Investigating cardiomyocyte dysfunction in dilated cardiomyopathy associated with Duchenne muscular dystrophy . Journal of Molecular and Cellular Cardiology vol. 173 , S18 - S18 .

Sebastian S, Weinstein LS, Ludwig A, Munroe P, Tinker A ( 2022 ) . Slowing Heart Rate Protects Against Pathological Cardiac Hypertrophy . Function vol. 4 , ( 1 ) Article zqac055 ,

Ramírez J, van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB ( 2022 ) . Prediction of Coronary Artery Disease and Major Adverse Cardiovascular Events Using Clinical and Genetic Risk Scores for Cardiovascular Risk Factors . Circulation: Genomic and Precision Medicine vol. 15 , ( 5 )

Wilson DGS, Tinker A, Iskratsch T ( 2022 ) . The role of the dystrophin glycoprotein complex in muscle cell mechanotransduction . Communications Biology vol. 5 , ( 1 ) Article 1022 ,

Ramírez J, Kiviniemi A, van Duijvenboden S, Tinker A, Lambiase PD, Junttila J, Perkiömäki JS, Huikuri HV et al. ( 2022 ) . ECG T‐Wave Morphologic Variations Predict Ventricular Arrhythmic Risk in Low‐ and Moderate‐Risk Populations . Journal of the American Heart Association vol. 11 , ( 17 ) Article e025897 ,

Young WJ, Lahrouchi N, Isaacs A, Duong T, Foco L, Ahmed F, Brody JA, Salman R et al. ( 2022 ) . Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways . Nature Communications vol. 13 , ( 1 ) Article 5144 ,

Williams JL, Paudyal A, Stewart M, Cutillas P, Tinker A, Metherell L ( 2022 ) . Abstract P2005: Loss Of Full-length Mylk3 Causes Dilated Cardiomyopathy Via A MYL2-independent Mechanism . Circulation Research vol. 131 , ( Suppl_1 )

Ramírez J, Van Duijvenboden S, Young W, Tinker A, Lambiase P, Orini M, Munroe P ( 2022 ) . Prediction of coronary artery disease and major adverse cardiovascular events using clinical and genetic risk scores for cardiovascular risk factors . Atherosclerosis vol. 355 , 3 - 4 .

Bercea C, Limbu R, Behnam K, Ng K-E, Aziz Q, Tinker A, Tamagnini F, Cotrell G et al. ( 2022 ) . Omega-3 polyunsaturated fatty acid-induced vasodilation in mouse aorta and mesenteric arteries is not mediated by ATP-sensitive potassium channels .

Jones A, Tinker A ( 2022 ) . BS11 Novel T-type calcium current pharmacology shows promise in the study of atrial fibrillation . Basic science . Conference: British Cardiovascular Society Annual Conference, ‘100 years of Cardiology’, 6–8 June 2022A150.1 - A150 .

Zawada D, Kornherr J, Meier AB, Santamaria G, Dorn T, Ortmann D, Lachmann M, Ortiz M et al. ( 2022 ) . Retinoic acid signaling modulation guides <i>in vitro</i> specification of human heart field-specific progenitor pools .

Morera C, Kim J, Paredes-Redondo A, Nobles M, Rybin D, Moccia R, Kowala A, Meng J et al. ( 2022 ) . CRISPR-mediated correction of skeletal muscle Ca²⁺handling in a novel DMD patient-derived pluripotent stem cell model .

Tinker A, Aziz Q, Li Y ( 2022 ) . ATP-Dependent K+ Channels . Encyclopedia of Molecular Pharmacology , Springer International Publishing

Olczak K, Aziz Q, Sebastian S, Rajeeve V, Otunsola R, Tinker A, Munroe P ( 2022 ) . Investigating the potential role of R-Ras in blood pressure control . JOURNAL OF HUMAN HYPERTENSION . vol. 36 , 2 - 3 .

Olczak KJ, Aziz Q, Sebastian S, Tinker A, Munroe PB ( 2022 ) . Investigating the potential role of the small GTPase R-Ras in mechanisms of blood pressure control . ACTA PHYSIOLOGICA . vol. 236 , 543 - 543 .

Ramirez J, van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB ( 2022 ) . Prediction of coronary artery disease: Do risk factor genetic risk scores add value? . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 30 , 188 - 189 .

Bercea CI, Limbu R, Behnam K, Ng K-E, Aziz Q, Tinker A, Tamagnini F, Cottrell G et al. ( 2022 ) . The role of ATP-sensitive potassium channels in omega-3 polyunsaturated fatty acid-mediated vasodilation in mouse aorta and mesenteric arteries . ACTA PHYSIOLOGICA . vol. 236 , 565 - 567 .

Christensen SL, Rasmussen RH, Cour SL, Ernstsen C, Hansen TF, Kogelman LJA, Lauritzen SP, Guzaite G et al. ( 2021 ) . Smooth muscle ATP-sensitive potassium channels mediate migraine-relevant hypersensitivity in mouse models . Cephalalgia vol. 42 , ( 2 ) 93 - 107 .

Williams J, paudyal A, Stewart M, Cutillas P, Cox RD, Tinker A, Metherell L ( 2021 ) . Abstract 14037: A Shorter Myosin Light Chain Kinase 3 Isoform Maintains Myosin Light Chain 2 Phosphorylation but Does Not Attenuate the Dilated Cardiomyopathy Seen in C57BL/6N Mice . Circulation vol. 144 , ( Suppl_1 )

Young WJ, Lahrouchi N, Isaacs A, Duong T, Foco L, Ahmed F, Brody JA, Salman R et al. ( 2021 ) . Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization .

Mistry A, Funge G, Sebastian S, Aziz Q, Solomou A, Vignola ML, Thong LC, Herincs M et al. . Acromegalic cardiomyopathy in pituitary-specific aryl hydrocarbon receptor interacting protein (Aip) gene knockout animals . Endocrine Abstracts .

Tinker A ( 2021 ) . Does knowledge of the mutation in hereditary long QT syndrome aid risk stratification? . European Heart Journal vol. 42 , ( 46 ) 4756 - 4758 .

Rathod VSHS, Harmer S, Royal A, Aziz Q, Lambiase P, Tinker A ( 2021 ) . B-PO02-015 ENHANCING MUTANT IKSCHANNEL ACTIVITY BY ALTERING ENDOGENOUS PIP2 LEVELS AND ITS INTERACTION WITH PKA SIGNALLING PATHWAY . Heart Rhythm vol. 18 , ( 8 ) S101 - S101 .

van Duijvenboden S, Ramírez J, Young WJ, Orini M, Mifsud B, Tinker A, Lambiase PD, Munroe PB ( 2021 ) . Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders . Human Molecular Genetics vol. 30 , ( 24 ) 2513 - 2523 .

Li Y, Aziz Q, Tinker A ( 2021 ) . The Pharmacology of ATP-Sensitive K+ Channels (KATP) . 357 - 378 .

Ng KE, Delaney PJ, Thenet D, Murtough S, Webb CM, Zaman N, Tsisanova E, Mastroianni G et al. ( 2021 ) . Early inflammation precedes cardiac fibrosis and heart failure in desmoglein 2 murine model of arrhythmogenic cardiomyopathy . Cell and Tissue Research vol. 386 , ( 1 ) 79 - 98 .

Ramírez J, Duijvenboden SV, Young WJ, Orini M, Jones AR, Lambiase PD, Munroe PB, Tinker A ( 2021 ) . Analysing electrocardiographic traits and predicting cardiac risk in UK biobank . JRSM Cardiovascular Disease vol. 10 , Article 20480040211023664 ,

van Duijvenboden S, Ramirez J, Orini M, Tinker A, Munroe P, Lambiase P ( 2021 ) . 85 Prognostic value of premature ventricular complexes during exercise stress testing in 56,000 individuals without known structural heart disease from UK biobank: is a single ectopic prognostic? . Cardiac rhythm management . Conference: British Cardiovascular Society Virtual Annual Conference, ‘Cardiology and the Environment’, 7–10 June 2021A68 - A68 .

Young W, Warren H, Mook-Kanamori D, Ramirez J, van Duijvenboden S, Orini M, Tinker A, van Heemst D et al. ( 2021 ) . BS8 Genetically-determined serum calcium levels influence markers of ventricular repolarisation: a mendelian randomisation study . Basic science . Conference: British Cardiovascular Society Virtual Annual Conference, ‘Cardiology and the Environment’, 7–10 June 2021A159.2 - A160 .

Young WJ, Warren HR, Mook-Kanamori DO, Ramírez J, van Duijvenboden S, Orini M, Tinker A, van Heemst D et al. ( 2021 ) . Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization: A Mendelian Randomization Study in the UK Biobank . Circulation: Genomic and Precision Medicine vol. 14 , ( 3 ) Article e003231 ,

Rathod V, Harmer SC, Royal A, Aziz Q, Lambiase P, Tinker A ( 2021 ) . Enhancing mutant IKS channel activity by increasing endogenous PIP2 levels and its interaction with PKA signalling pathway . EP Europace vol. 23 , ( Supplement_3 ) Article euab116.543 ,

Sebastian S, Nobles M, Tsisanova E, Ludwig A, Munroe PB, Tinker A ( 2021 ) . The role of resistance to inhibitors of cholinesterase 8b in the control of heart rate . Physiological Genomics vol. 53 , ( 4 ) 150 - 159 .

Mensah-Kane J, Schmidt AF, Hingorani AD, Finan C, Chen Y, van Duijvenboden S, Orini M, Lambiase PD et al. ( 2021 ) . No Clinically Relevant Effect of Heart Rate Increase and Heart Rate Recovery During Exercise on Cardiovascular Disease: A Mendelian Randomization Analysis . Frontiers in Genetics vol. 12 , Article 569323 ,

Young WJ, van Duijvenboden S, Ramírez J, Jones A, Tinker A, Munroe PB, Lambiase PD, Orini M ( 2021 ) . A Method to Minimise the Impact of ECG Marker Inaccuracies on the Spatial QRS-T angle: Evaluation on 1,512 Manually Annotated ECGs . Biomedical Signal Processing and Control vol. 64 , Article 102305 , 102305 - 102305 .

Ramirez J, van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB ( 2021 ) . Prediction of Coronary Artery Disease using Traditional and Genetic Risk Scores for Cardiovascular Risk Factors . GENETIC EPIDEMIOLOGY . vol. 45 , 783 - 783 .

Young W, Srinivasan N, Tinker A, Munroe P, Lambiase P, Orini M . Comparison of the spatial QRS-T angle With Intra-cardiac Markers of Depolarisation and Repolarisation . Computing in Cardiology Conference (CinC) . Conference: 2020 Computing in Cardiology Conference

van Duijvenboden S, Ramírez J, J. Young W, Tinker A, B. Munroe P, D. Lambiase P, Orini M . Evaluating the Impact of Physiological Variability in Genome-Wide Association Studies of Resting Heart Rate . Computing in Cardiology Conference (CinC) . Conference: 2020 Computing in Cardiology Conference

Ramírez J, van Duijvenboden S, Young W, Tinker A, Lambiase P, Munroe P, Orini M . Interaction Between ECG and Genetic Markers of Coronary Artery Disease . Computing in Cardiology Conference (CinC) . Conference: 2020 Computing in Cardiology Conference

Ramírez J, van Duijvenboden S, Tinker A, Lambiase P, Munroe P, Orini M . Sex Differences in the Morphology of RR-Matched T-waves . Computing in Cardiology Conference (CinC) . Conference: 2020 Computing in Cardiology Conference

Young W, Ramírez J, van Duijvenboden S, Tinker A, Lambiase P, Munroe P, Orini M . Will Genetic Data Significantly Change Cardiovascular Risk Prediction in Daily Practice? . Computing in Cardiology Conference (CinC) . Conference: 2020 Computing in Cardiology Conference

Ramírez J, Tinker A ( 2020 ) . Ventricular Restitution Predicts Paroxysmal Atrial Fibrillation in Horses . Function vol. 2 , ( 1 ) Article zqaa038 ,

Balestrini S, Mikati MA, Álvarez-García-Rovés R, Carboni M, Hunanyan AS, Kherallah B, McLean M, Prange L et al. ( 2020 ) . Cardiac phenotype in\n <i>ATP1A3</i>\n -related syndromes . Neurology vol. 95 , ( 21 )

Li Y, Aziz Q, Anderson N, Ojake L, Tinker A ( 2020 ) . Endothelial ATP-Sensitive Potassium Channel Protects Against the Development of Hypertension and Atherosclerosis . Hypertension vol. 76 , ( 3 ) 776 - 784 .

van Duijvenboden S, Ramírez J, Young WJ, Mifsud B, Orini M, Tinker A, Munroe PB, Lambiase PD ( 2020 ) . Genetic Basis and Prognostic Value of Exercise QT Dynamics . Circulation: Genomic and Precision Medicine vol. 13 , ( 4 ) Article e002774 ,

Aziz Q, Chen J, Moyes AJ, Li Y, Anderson NA, Ang R, Aksentijevic D, Sebastian S et al. ( 2020 ) . Vascular KATP channels protect from cardiac dysfunction and preserve cardiac metabolism during endotoxemia . Journal of Molecular Medicine vol. 98 , ( 8 ) 1149 - 1160 .

Villar D, Frost S, Deloukas P, Tinker A ( 2020 ) . The contribution of non-coding regulatory elements to cardiovascular disease . Open Biology vol. 10 , ( 7 ) Article 200088 ,

Ng KE, Delaney PJ, Thenet D, Murtough S, Webb CM, Tsisanova E, Walker SLM, Westaby JD et al. ( 2020 ) . Early cardiac inflammation as a driver of murine model of Arrhythmogenic Cardiomyopathy .

Aziz Q, Tinker A ( 2020 ) . The Pathophysiology of Cardiac Abnormalities in Cantu Syndrome: Perspective on “The Mechanism of High-Output Cardiac Hypertrophy Arising From Potassium Channel Gain-of-Function in Cantú Syndrome” . Function vol. 1 , ( 1 ) Article zqaa005 ,

Ramírez J, van Duijvenboden S, Young WJ, Orini M, Lambiase PD, Munroe PB, Tinker A ( 2020 ) . Common Genetic Variants Modulate the Electrocardiographic Tpeak-to-Tend Interval . The American Journal of Human Genetics vol. 106 , ( 6 ) 764 - 778 .

Ntalla I, Weng L-C, Cartwright JH, Hall AW, Sveinbjornsson G, Tucker NR, Choi SH, Chaffin MD et al. ( 2020 ) . Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction . Nature Communications vol. 11 , ( 1 ) Article 2542 ,

Williams JL, Paudyal A, Awad S, Nicholson J, Grzesik D, Botta J, Meimaridou E, Maharaj AV et al. ( 2020 ) . <i>Mylk3</i>null C57BL/6N mice develop cardiomyopathy, whereas<i>Nnt</i>null C57BL/6J mice do not . Life Science Alliance vol. 3 , ( 4 ) e201900593 - e201900593 .

Tinker A, Aziz Q, Li Y ( 2020 ) . ATP-Dependent K + Channels . Encyclopedia of Molecular Pharmacology , Springer International Publishing

Aziz Q, Nobles M, Tinker A ( 2020 ) . Acute Isolation of Cells from Murine Sino-atrial Node . BIO-PROTOCOL vol. 10 , ( 1 )

Aziz Q, Nobles M, Tinker A ( 2020 ) . Whole-cell and Perforated Patch-clamp Recordings from Acutely-isolated Murine Sino-atrial Node Cells . BIO-PROTOCOL vol. 10 , ( 1 )

Ramírez J, van Duijvenboden S, Aung N, Laguna P, Pueyo E, Tinker A, Lambiase PD, Orini M et al. ( 2019 ) . Cardiovascular Predictive Value and Genetic Basis of Ventricular Repolarization Dynamics . Circulation: Arrhythmia and Electrophysiology vol. 12 , ( 10 ) Article e007549 ,

Finlay M, Bhar-Amato J, Ng K-E, Santos D, Orini M, Vyas V, Taggart P, Grace AA et al. ( 2019 ) . Autonomic modulation of the electrical substrate in mice haploinsufficient for cardiac sodium channels: a model of the Brugada syndrome . American Journal of Physiology-Cell Physiology vol. 317 , ( 3 ) C576 - C583 .

Cartwright JH, Aziz Q, Harmer SC, Thayyil S, Tinker A, Munroe PB ( 2019 ) . Genetic variants in TRPM7 associated with unexplained stillbirth modify ion channel function . Human Molecular Genetics vol. 29 , ( 11 ) 1797 - 1807 .

Thomas AM, Cabrera CP, Finlay M, Lall K, Nobles M, Schilling RJ, Wood K, Mein CA et al. ( 2019 ) . Differentially expressed genes for atrial fibrillation identified by RNA sequencing from paired human left and right atrial appendages . Physiological Genomics vol. 51 , ( 8 ) 323 - 332 .

Ntalla I, Weng L-C, Cartwright JH, Hall AW, Sveinbjornsson G, Tucker NR, Choi SH, Chaffin MD et al. ( 2019 ) . Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction .

Noordam R, Young WJ, Salman R, Kanters JK, van den Berg ME, van Heemst D, Lin HJ, Barreto SM et al. ( 2019 ) . Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals . Journal of the American College of Cardiology vol. 73 , ( 24 ) 3118 - 3131 .

Ramirez J, van Duijvenboden S, Tinker A, Lambiase P, Orini M, Munroe PB ( 2019 ) . 21 The cardiovascular predictive value and genetic basis of T-wave morphology . Cardiac rhythm management . Conference: British Cardiovascular Society Annual Conference ‘Digital Health Revolution’ 3–5 June 2019A18.2 - A19 .

van Duijvenboden S, Ramirez J, Orini M, Tinker A, Munroe PB, Lambiase P ( 2019 ) . 22 Cardiac repolarization during exercise reveals independent prognostic information for cardiovascular risk prediction . Cardiac Rhythm Management . Conference: British Cardiovascular Society Annual Conference ‘Digital Health Revolution’ 3–5 June 2019A19 - A20 .

Maruthappu T, Posafalvi A, Castelletti S, Delaney PJ, Syrris P, O'Toole EA, Green KJ, Elliott PM et al. ( 2019 ) . DSP mutations and arrhythmogenic cardiomyopathy . British Journal of Dermatology vol. 180 , ( 5 )

Maruthappu T, Posafalvi A, Castelletti S, Delaney PJ, Syrris P, O'Toole EA, Green KJ, Elliott PM et al. ( 2019 ) . DSP 突变与致心律失常性心肌病 . British Journal of Dermatology vol. 180 , ( 5 )

Zhou X, Bueno-Orovio A, Schilling RJ, Kirkby C, Denning C, Rajamohan D, Burrage K, Tinker A et al. ( 2019 ) . Investigating the Complex Arrhythmic Phenotype Caused by the Gain-of-Function Mutation KCNQ1-G229D . Frontiers in Physiology vol. 10 , Article 259 ,

Honarbakhsh S, Hunter RJ, Finlay M, Ullah W, Keating E, Tinker A, Schilling RJ ( 2019 ) . Development, in vitro validation and human application of a novel method to identify arrhythmia mechanisms: The stochastic trajectory analysis of ranked signals mapping method . Journal of Cardiovascular Electrophysiology vol. 30 , ( 5 ) 691 - 701 .

Maruthappu T, Posafalvi A, Castelletti S, Delaney PJ, Syrris P, O'Toole EA, Green KJ, Elliott PM et al. ( 2019 ) . Loss‐of‐function desmoplakin I and II mutations underlie dominant arrhythmogenic cardiomyopathy with a hair and skin phenotype . British Journal of Dermatology vol. 180 , ( 5 ) 1114 - 1122 .

Mosqueira D, Mannhardt I, Bhagwan JR, Lis-Slimak K, Katili P, Scott E, Hassan M, Prondzynski M et al. ( 2019 ) . CRISPR/Cas9 genome editing in human pluripotent stem cell-cardiomyocytes provides a platform for modeling hypertrophic cardiomyopathy . HUMAN GENE THERAPY . vol. 30 , A5 - A5 .

Balestrini S, Mikati M, Garcia-Roves RA, Carboni M, Hunanyan A, Kherallah B, McLean M, Prange L et al. ( 2019 ) . Cardiac Phenotype In <i>ATP1A3</i> Related-Syndromes: A Multicentre Study . EPILEPSIA . vol. 60 , 173 - 173 .

Ramirez J, van Duijvenboden S, Ntalla I, Mifsud B, Warren HR, Tzanis E, Orini M, Tinker A et al. ( 2019 ) . Identification of novel loci for heart rate response to exercise and recovery . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 27 , 135 - 135 .

Scott ES, Awford J, Hyde R, Hassan M, Hashmi L, Harmer S, Fischer P, Kellam B et al. ( 2019 ) . Using bioluminescent hiPSC reporter lines and high content screening to identify novel compounds for cardiomyocyte maturation . HUMAN GENE THERAPY . vol. 30 , A8 - A8 .

Ramírez J, van Duijvenboden S, Laguna P, Pueyo E, Tinker A, Lambiase P, Munroe P, Orini M . Assessing a Warping Methodology for the Identification of Increased Cardiovascular Risk Based on the HR Profile Morphology . Computing in Cardiology Conference (CinC) . Conference: 2018 Computing in Cardiology Conference

Aziz Q, Li Y, Tinker A ( 2018 ) . Potassium channels in the sinoatrial node and their role in heart rate control . Channels vol. 12 , ( 1 ) 356 - 366 .

Ramírez J, van Duijvenboden S, Orini M, Tinker A, Munroe PB, Lambiase PD ( 2018 ) . 23T-wave morphology restitution predicts arrhythmic risk in the UK biobank cohort . EP Europace vol. 20 , ( suppl_4 ) iv10 - iv11 .

van Duijvenboden S, Ramírez J, Orini M, Tinker A, Munroe PB, Lambiase PD ( 2018 ) . 2QT interval and exercise qt dynamics from 58,852 individuals in UK biobank predict ventricular arrhythmias and heart failure . EP Europace vol. 20 , ( suppl_4 ) iv1 - iv1 .

Cartwright J, Aziz Q, Harmer S, Tinker A, Munroe P ( 2017 ) . Functional Studies of TRPM7 – a Candidate Gene for Stillbirth? . The FASEB Journal . vol. 31 ,

Tinker A, Aziz Q, Li Y, Specterman M ( 2018 ) . ATP‐Sensitive Potassium Channels and Their Physiological and Pathophysiological Roles . Comprehensive Physiology vol. 8 , ( 4 ) 1463 - 1511 .

Ang R, Mastitskaya S, Hosford PS, Basalay M, Specterman M, Aziz Q, Li Y, Orini M et al. ( 2018 ) . Modulation of Cardiac Ventricular Excitability by GLP-1 (Glucagon-Like Peptide-1) . Circulation: Arrhythmia and Electrophysiology vol. 11 , ( 10 ) Article e006740 ,

Calmont A, Anderson N, Suntharalingham JP, Ang R, Tinker A, Scambler PJ ( 2018 ) . Defective Vagal Innervation in Murine Tbx1 Mutant Hearts . Journal of Cardiovascular Development and Disease vol. 5 , ( 4 ) 49 - 49 .

Tinker A, Aziz Q, Li Y, Specterman M ( 2018 ) . ATP‐Sensitive Potassium Channels and Their Physiological and Pathophysiological Roles . 1463 - 1511 .

Bhar-Amato J, Finlay M, Santos D, Orini M, Chaubey S, Vyas V, Taggart P, Grace AA et al. ( 2018 ) . Pharmacological Modulation of Right Ventricular Endocardial-Epicardial Gradients in Brugada Syndrome . Circulation: Arrhythmia and Electrophysiology vol. 11 , ( 9 ) Article e006330 ,

Castelletti S, Maruthappu T, Posafalvi A, Syrris P, O'Toole EA, Green KJ, Tinker A, McKenna WJ et al. ( 2018 ) . P5709Hair and cutaneous phenotypes linked to Arrhythmogenic Cardiomyopathy caused by Desmoplakin haploinsufficiency: an additional disease marker . European Heart Journal vol. 39 , ( suppl_1 )

Prins BP, Mead TJ, Brody JA, Sveinbjornsson G, Ntalla I, Bihlmeyer NA, van den Berg M, Bork-Jensen J et al. ( 2018 ) . Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6 . Genome Biology vol. 19 , ( 1 ) Article 87 ,

Hosford PS, Christie IN, Niranjan A, Aziz Q, Anderson N, Ang R, Lythgoe MF, Wells JA et al. ( 2018 ) . A critical role for the ATP-sensitive potassium channel subunit K_IR6.1 in the control of cerebral blood flow . Journal of Cerebral Blood Flow &amp; Metabolism vol. 39 , ( 10 ) 2089 - 2095 .

Aziz Q, Finlay M, Montaigne D, Ojake L, Li Y, Anderson N, Ludwig A, Tinker A ( 2018 ) . ATP-sensitive potassium channels in the sinoatrial node contribute to heart rate control and adaptation to hypoxia . Journal of Biological Chemistry vol. 293 , ( 23 ) 8912 - 8921 .

Ramírez J, Duijvenboden SV, Ntalla I, Mifsud B, Warren HR, Tzanis E, Orini M, Tinker A et al. ( 2018 ) . Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system . Nature Communications vol. 9 , ( 1 ) Article 1947 ,

Mosqueira D, Mannhardt I, Bhagwan JR, Lis-Slimak K, Katili P, Scott E, Hassan M, Prondzynski M et al. ( 2018 ) . CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy . European Heart Journal vol. 39 , ( 43 ) 3879 - 3892 .

Nobles M, Montaigne D, Sebastian S, Birnbaumer L, Tinker A ( 2018 ) . Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K⁺ currents in adult murine atria . American Journal of Physiology-Cell Physiology vol. 314 , ( 5 ) C616 - C626 .

Rathod VS, Harmer SC, Salsbury GA, Bitner-Glindzicz M, Lambiase PD, Tinker A ( 2018 ) . P449The novel long QT syndrome type 1 mutation KCNQ1-p.Thr247dup causes severe channel dysfunction but retains preserved adrenergic regulation . EP Europace vol. 20 , ( suppl_1 ) i87 - i87 .

Arcidiacono P, Webb CM, Brooke MA, Zhou H, Delaney PJ, Ng K-E, Blaydon DC, Tinker A et al. ( 2018 ) . p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response . Nature Communications vol. 9 , ( 1 ) Article 1021 ,

Tinker A, Finlay M, Nobles M, Opel A ( 2018 ) . Erratum to “The contribution of pathways initiated via the Gq\\11 G-protein family to atrial fibrillation” [Pharmacol. Res. 105 (2016) 54–61] . Pharmacological Research vol. 129 , 544 - 544 .

Orini M, Tinker A, Munroe PB, Lambiase PD ( 2018 ) . Correction: Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort . PLOS ONE vol. 13 , ( 2 ) e0193039 - e0193039 .

Lovering RC, Roncaglia P, Howe DG, Laulederkind SJF, Khodiyar VK, Berardini TZ, Tweedie S, Foulger RE et al. ( 2018 ) . Improving Interpretation of Cardiac Phenotypes and Enhancing Discovery With Expanded Knowledge in the Gene Ontology . Circulation: Genomic and Precision Medicine vol. 11 , ( 2 ) Article e001813 ,

Aziz Q, Li Y, Tinker A ( 2018 ) . Endothelial biology and ATP-sensitive potassium channels . Channels vol. 12 , ( 1 ) 45 - 46 .

Mosqueira D, Mannhardt I, Bhagwan JR, Lis-Slimak K, Katili P, Scott E, Hassan M, Prondzynski M et al. ( 2018 ) . CRISPR/Cas9 gene editing in human pluripotent stem cell-cardiomyocytes provides a platform for modeling hypertrophic cardiomyopathy . HUMAN GENE THERAPY . vol. 29 , A93 - A94 .

Castelletti S, Maruthappu T, Posafalvi A, Syrris P, O'Toole EA, Green KJ, Tinker A, McKenna WJ et al. ( 2018 ) . Hair and cutaneous phenotypes linked to Arrhythmogenic Cardiomyopathy caused by Desmoplakin haploinsufficiency: an additional disease marker . EUROPEAN HEART JOURNAL . vol. 39 , 1206 - 1206 .

Munroe PB, Addison S, Abrams DJ, Sebire NJ, Cartwright J, Donaldson I, Cohen MM, Mein C et al. ( 2018 ) . Postmortem Genetic Testing for Cardiac Ion Channelopathies in Stillbirths . Circulation: Genomic and Precision Medicine vol. 11 , ( 1 )

Miller DC, Harmer SC, Poliandri A, Nobles M, Edwards EC, Ware JS, Sharp TV, McKay TR et al. ( 2017 ) . Ajmaline blocks I Na and I Kr without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters . Stem Cell Research vol. 25 , 233 - 244 .

Lane JD, Tinker A ( 2017 ) . Have the Findings from Clinical Risk Prediction and Trials Any Key Messages for Safety Pharmacology? . Frontiers in Physiology vol. 8 , Article 890 ,

Yavari A, Bellahcene M, Bucchi A, Sirenko S, Pinter K, Herring N, Jung JJ, Tarasov KV et al. ( 2017 ) . Mammalian γ2 AMPK regulates intrinsic heart rate . Nature Communications vol. 8 , ( 1 ) Article 1258 ,

Royal AA, Tinker A, Harmer SC ( 2017 ) . Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking . PLOS ONE vol. 12 , ( 10 ) e0186293 - e0186293 .

Aziz Q, Li Y, Anderson N, Ojake L, Tsisanova E, Tinker A ( 2017 ) . Molecular and functional characterization of the endothelial ATP-sensitive potassium channel . Journal of Biological Chemistry vol. 292 , ( 43 ) 17587 - 17597 .

Lane JD, Montaigne D, Tinker A ( 2017 ) . Tissue-Level Cardiac Electrophysiology Studied in Murine Myocardium Using a Microelectrode Array: Autonomic and Thermal Modulation . vol. 250 , is. 5 , pp. 471 - 481 . Springer Science and Business Media LLC

Orini M, Tinker A, Munroe PB, Lambiase PD ( 2017 ) . Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort . PLOS ONE vol. 12 , ( 9 ) e0183732 - e0183732 .

Tinker A ( 2017 ) . The mechanisms of ventricular arrhythmia in Chagas disease . International Journal of Cardiology vol. 240 , 372 - 373 .

Munroe PB, Tinker A ( 2017 ) . Heritability of resting heart rate and association with mortality in middle-aged and elderly twins . Heart vol. 104 , ( 1 ) 6 - 7 .

Zhang Y, Marrion N, Harmer S, Mohamed R, Tinker A, Hancox J ( 2017 ) . 227hERG potassium channel modulation by P127T KCNE1 . EP Europace vol. 19 , ( suppl_3 ) iii22 - iii22 .

Finlay M, Harmer SC, Tinker A ( 2017 ) . The control of cardiac ventricular excitability by autonomic pathways . Pharmacology &amp; Therapeutics vol. 174 , 97 - 111 .

Poliandri A, Miller D, Howard S, Nobles M, Ruiz-Babot G, Harmer S, Tinker A, McKay T et al. ( 2017 ) . Generation of kisspeptin-responsive GnRH neurons from human pluripotent stem cells . Molecular and Cellular Endocrinology vol. 447 , 12 - 22 .

van den Berg ME, Warren HR, Cabrera CP, Verweij N, Mifsud B, Haessler J, Bihlmeyer NA, Fu Y-P et al. ( 2017 ) . Discovery of novel heart rate-associated loci using the Exome Chip . Human Molecular Genetics vol. 26 , ( 12 ) 2346 - 2363 .

Champney F, Maddock LJ, Welford J, Kemp J, Allan V, Persidskikh Y, Orini M, Ang R et al. ( 2016 ) . ORAL ABSTRACTS (1)Allied Professionals7CRYOABLATION FOR PAROXYSMAL ATRIAL FIBRILLATION - IS AN EP LAB REQUIRED?8A PATHWAY TO SAFETY - ANTICOAGULATION COMPLIANCE IN CIED PATIENTS WITH AF9UNDERSTANDING THE WAYS IN WHICH OCCUPATION IS AFFECTED BY POSTURAL TACHYCARDIA SYNDROME: A UK OCCUPATIONAL THERAPY PERSPECTIVE10DEVELOPMENT OF AN INTERGRATED SUPPORT PATHWAY FOR PATIENTS FULFILLING NICE CRITERIA FOR AN INTERNAL CARDIOVASCULAR DEBRIBRILLATOR (ICD) IN A DISTRICT GENERAL HOSPITAL11ARE CARDIOVASCULAR RISK FACTORS ALSO ASSOCIATED WITH THE INCIDENCE OF ATRIAL FIBRILLATION? A SYSTEMATIC REVIEW AND FIELD SYNOPSIS OF 23 FACTORS IN 32 INITIALLY HEALTHY COHORTS OF 20 MILLION PARTICIPANTS12BRAIN MRI FINDINGS IN PATIENTS WITH ATRIAL FIBRILLATION UNDERGOING CARDIOVERSIONBasic Science/Sudden Cardiac Death13PRELIMINARY ASSESSMENT OF THE “RE-ENTRY VULNERABILITY INDEX” AS A MARKER OF CARDIAC INSTABILITY IN THE HUMAN HEART USING WHOLE-HEART CONTACT EPICARDIAL MAPPING14OPTOGENETIC STIMULATION OF BRAINSTEM'S VAGAL PREGANGLIONIC NEURONES IS ASSOCIATED WITH NEURONAL NITRIC OXIDE SYNTHASE-DEPENDENT PROLONGATION OF VENTRICULAR EFFECTIVE REFRACTORY PERIOD15A DYNAMIC-CLAMP STUDY OF L-TYPE Ca2+ CURRENT IN RABBIT AND HUMAN ATRIAL MYOCYTES: THE CONTRIBUTION OF WINDOW ICaL TO EARLY AFTERDEPOLARISATIONS16WHOLE EXOME SEQUENCING IN SUDDEN INFANT DEATH SYNDROME17MEDIUM TERM SURVIVAL AND FAMILY SCREENING OUTCOMES IN AN IDIOPATHIC VENTRICULAR FIBRILLATION COHORT - A MULTICENTRE EXPERIENCE18CLINICAL CHARACTERISTICS OF SCD SURVIVORS WITH BRUGADA SYNDROME:- ARE SPONSANEOUS TYPE I ECG AND PREVIOUS SYNCOPE REALLY ASSOCIATED WITH HIGH RISK? . Europace vol. 18 , ( suppl 2 ) ii4 - ii7 .

Mellor G, Orini M, Specterman MJ, Sawhney VS, Merghani A, Claridge S, Laksman Z, Gerull B et al. ( 2016 ) . YOUNG INVESTIGATORS COMPETITION1GENETIC ANALYSIS IN THE EVALUATION OF UNEXPLAINED CARDIAC ARREST: FROM THE CARDIAC ARREST SURVIVORS WITH PRESERVED EJECTION FRACTION REGISTRY (CASPER)2IN-VIVO WHOLE HEART CONTACT MAPPING DATA AND A SIMPLE MATHEMATICAL FRAMEWORK TO UNDERSTAND THE INTERACTIONS BETWEEN ACTIVATION AND REPOLARIZATION RESITUTION DYNAMICS IN THE INTACT HUMAN HEART3THE K(ATP) CHANNEL OPENER DIAZOXIDE REDUCES AUTOMATICITY IN AN IN VITRO ATRIAL CELL MODEL - POTENTIAL FOR K(ATP) CHANNELS AS A DRUG TARGET FOR ATRIAL ARRHYTHMIAS4LONG-TERM OUTCOMES AFTER CATHETER ABLATION OF VENTRICULAR TACHYCARDIA IN PATIENTS WITH STRUCTURAL HEART DISEASE: A MULTICENTRE UK STUDY5THE BURDEN OF ARRHYTHMIAS IN LIFE-LONG ENDURANCE ATHLETES6CARDIAC MAGNETIC RESONANCE IMAGING RISK STRATIFICATION USING MARKERS OF REGIONAL AND DIFFUSE FIBROSIS FOR IMPLANTABLE CARDIOVERTER DEFIBRILLATOR THERAPY: THE VALUE OF T1 MAPPING IN NON-ISCHEMIC PATIENTS . Europace vol. 18 , ( suppl 2 ) ii1 - ii3 .

( 2016 ) . Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension . Nature Genetics vol. 48 , ( 10 ) 1151 - 1161 .

Ang R, Abramowitz J, Birnbaumer L, Gourine AV, Tinker A ( 2016 ) . The role of G<i>α</i>_O‐mediated signaling in the rostral ventrolateral medulla oblongata in cardiovascular reflexes and control of cardiac ventricular excitability . Physiological Reports vol. 4 , ( 15 ) Article e12860 ,

Ishida H, Saba R, Kokkinopoulos I, Hashimoto M, Yamaguchi O, Nowotschin S, Shiraishi M, Ruchaya P et al. ( 2016 ) . GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway . Cell Reports vol. 16 , ( 4 ) 1026 - 1038 .

Zhou X, Harmer S, Bueno-Orovio A, Burrage K, Tinker A, Rodriguez B ( 2016 ) . 57-03: How Can a Gain-of-Function Mutation in KCNQ1 Lead to Action Potential Prolongation? . EP Europace vol. 18 , ( suppl_1 ) i167 - i167 .

Tinker A, Finlay M, Nobles M, Opel A ( 2016 ) . The contribution of pathways initiated via the Gq\\11 G-protein family to atrial fibrillation . Pharmacological Research vol. 105 , 54 - 61 .

Harmer SC, Tinker A ( 2016 ) . The impact of recent advances in genetics in understanding disease mechanisms underlying the long QT syndromes . Biological Chemistry vol. 397 , ( 7 ) 679 - 693 .

Ang R, Abramowitz J, Birnbaumer L, Gourine AV, Tinker A ( 2016 ) . Loss of the inhibitory GalphaO protein in the rostral ventrolateral medulla of the brainstem leads to abnormalities in cardiovascular reflexes and altered ventricular excitablitiy . CARDIOVASCULAR RESEARCH . vol. 111 , S98 - S98 .

Richards DA, Fletcher SA, Nobles M, Kossen H, Tedaldi L, Chudasama V, Tinker A, Baker JR ( 2016 ) . Photochemically re-bridging disulfide bonds and the discovery of a thiomaleimide mediated photodecarboxylation of C-terminal cysteines . Organic &amp; Biomolecular Chemistry vol. 14 , ( 2 ) 455 - 459 .

Rodriguez B, Carusi A, Abi-Gerges N, Ariga R, Britton O, Bub G, Bueno-Orovio A, Burton RAB et al. ( 2015 ) . Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop . Europace vol. 18 , ( 9 ) 1287 - 1298 .

Machhada A, Ang R, Ackland GL, Ninkina N, Buchman VL, Lythgoe MF, Trapp S, Tinker A et al. ( 2015 ) . Control of ventricular excitability by neurons of the dorsal motor nucleus of the vagus nerve . Heart Rhythm vol. 12 , ( 11 ) 2285 - 2293 .

Munroe PB, Tinker A ( 2015 ) . Genome-wide association studies and contribution to cardiovascular physiology . Physiological Genomics vol. 47 , ( 9 ) 365 - 375 .

Opel A, Nobles M, Montaigne D, Finlay M, Anderson N, Breckenridge R, Tinker A ( 2015 ) . Absence of the Regulator of G-protein Signaling, RGS4, Predisposes to Atrial Fibrillation and Is Associated with Abnormal Calcium Handling . Journal of Biological Chemistry vol. 290 , ( 31 ) 19233 - 19244 .

Nessa A, Aziz QH, Thomas AM, Harmer SC, Tinker A, Hussain K ( 2015 ) . Molecular mechanisms of congenital hyperinsulinism due to autosomal dominant mutations in<i>ABCC8</i> . Human Molecular Genetics vol. 24 , ( 18 ) 5142 - 5153 .

Yeoh A, Finlay M, Anderson N, Harmer S, Tinker A ( 2015 ) . 162 Simultaneous measurement of calcium transients and electrical activity in murine cardiac tissue – a novel system for the study of cardiac arrhythmia . Heart . vol. 101 , A92 - A93 .

Aziz Q, Li Y, Tinker A ( 2015 ) . ATP-sensitive potassium channels and vascular function . Channels vol. 9 , ( 1 ) 3 - 4 .

Notari M, Hu Y, Sutendra G, Dedeić Z, Lu M, Dupays L, Yavari A, Carr CA et al. ( 2015 ) . iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death . Proceedings of the National Academy of Sciences vol. 112 , ( 9 )

Fletcher SA, Sin PKB, Nobles M, Årstad E, Tinker A, Baker JR ( 2015 ) . A dual optical and nuclear imaging reagent for peptide labelling via disulfide bridging . Organic &amp; Biomolecular Chemistry vol. 13 , ( 37 ) 9559 - 9563 .

Machhada A, Ang R, Ackland G, Ninkina N, Buchman V, Lythgoe MF, Trapp S, Tinker A et al. ( 2015 ) . Reduced activity of dorsal vagal preganglionic neurones associated with synuclein pathology predisposes the heart to ventricular arrhythmia . EUROPEAN HEART JOURNAL . vol. 36 , 215 - 215 .

Arya VB, Aziz Q, Nessa A, Tinker A, Hussain K ( 2014 ) . Congenital hyperinsulinism: clinical and molecular characterisation of compound heterozygous ABCC8 mutation responsive to Diazoxide therapy . International Journal of Pediatric Endocrinology vol. 2014 , ( 1 ) Article 24 ,

Lambiase PD, Tinker A ( 2014 ) . Connexins in the heart . Cell and Tissue Research vol. 360 , ( 3 ) 675 - 684 .

Lane JD, Abramowitz J, Birnbaumer L, Tinker A ( 2014 ) . 51 * Cardiac specific knockout of G-alpha-i2 in a murine model of heart failure . Europace vol. 16 , ( suppl 3 ) iii20 - iii20 .

Aziz Q, Thomas AM, Gomes J, Ang R, Sones WR, Li Y, Ng K-E, Gee L et al. ( 2014 ) . The ATP-Sensitive Potassium Channel Subunit, Kir6.1, in Vascular Smooth Muscle Plays a Major Role in Blood Pressure Control . Hypertension vol. 64 , ( 3 ) 523 - 529 .

Harmer SC, Mohal JS, Royal AA, McKenna WJ, Lambiase PD, Tinker A ( 2014 ) . Cellular mechanisms underlying the increased disease severity seen for patients with long QT syndrome caused by compound mutations in KCNQ1 . Biochemical Journal vol. 462 , ( 1 ) 133 - 142 .

Tinker A, Harmer SC ( 2014 ) . K⁺channels in the heart: new insights and therapeutic implications . Expert Review of Clinical Pharmacology vol. 3 , ( 3 ) 305 - 319 .

Youziel J, Akhbar AR, Aziz Q, Smith MEB, Caddick S, Tinker A, Baker JR ( 2014 ) . Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence ‘turn-on’ reagents . Org. Biomol. Chem. vol. 12 , ( 4 ) 557 - 560 .

Tinker A, Aziz Q, Thomas A ( 2013 ) . The role of <scp>ATP</scp>‐sensitive potassium channels in cellular function and protection in the cardiovascular system . British Journal of Pharmacology vol. 171 , ( 1 ) 12 - 23 .

Tinker A, Harmer SC ( 2013 ) . Potassium channels regulating the electrical activity of the heart . Translational Vascular Medicine: Pathogenesis, Diagnosis, and Treatment , vol. 9780857299208 ,

Posokhova E, Ng D, Opel A, Masuho I, Tinker A, Biesecker LG, Wickman K, Martemyanov KA ( 2013 ) . Essential Role of the m2R-RGS6-IKACh Pathway in Controlling Intrinsic Heart Rate Variability . PLoS ONE vol. 8 , ( 10 ) e76973 - e76973 .

Ang R, Birnbaumer L, Gourine AV, Tinker A ( 2013 ) . The role of GalphaO-mediated signalling in the central nervous mechanisms controlling sympathetic outflow to the heart . European Heart Journal vol. 34 , ( suppl 1 ) P5030 - P5030 .

Sebastian S, Ang R, Abramowitz J, Weinstein LS, Chen M, Ludwig A, Birnbaumer L, Tinker A ( 2013 ) . The in vivo regulation of heart rate in the murine sinoatrial node by stimulatory and inhibitory heterotrimeric G proteins . American Journal of Physiology-Regulatory, Integrative and Comparative Physiology vol. 305 , ( 4 ) R435 - R442 .

Ang R, Birnbaumer L, Gourine A, Tinker A ( 2013 ) . 223 THE ROLE OF INHIBITORY G PROTEIN GALPHAO-MEDIATED SIGNALLING IN THE CENTRAL NERVOUS MECHANISMS CONTROLLING SYMPATHETIC OUTFLOW TO THE HEART . Heart . vol. 99 , A121.1 - A121 .

Schwarzer S, Mashanov GI, Molloy JE, Tinker A ( 2013 ) . Using Total Internal Reflection Fluorescence Microscopy to Observe Ion Channel Trafficking and Assembly . 201 - 208 .

Telezhkin V, Thomas AM, Harmer SC, Tinker A, Brown DA ( 2013 ) . A basic residue in the proximal C-terminus is necessary for efficient activation of the M-channel subunit Kv7.2 by PI(4,5)P2 . Pflügers Archiv - European Journal of Physiology vol. 465 , ( 7 ) 945 - 953 .

Ang R, Birnbaumer L, Gourine AV, Tinker A ( 2013 ) . The role of GalphaO-mediated signalling in the central nervous mechanisms controlling sympathetic outflow to the heart . EUROPEAN HEART JOURNAL . vol. 34 , 928 - 928 .

Maden CH, Gomes J, Schwarz Q, Davidson K, Tinker A, Ruhrberg C ( 2012 ) . NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system . Developmental Biology vol. 369 , ( 2 ) 277 - 285 .

Risebro CA, Petchey LK, Smart N, Gomes J, Clark J, Vieira JM, Yanni J, Dobrzynski H et al. ( 2012 ) . Epistatic Rescue of Nkx2.5 Adult Cardiac Conduction Disease Phenotypes by Prospero-Related Homeobox Protein 1 and HDAC3 . Circulation Research vol. 111 , ( 2 )

Harmer SC, Mohal JS, Kemp D, Tinker A ( 2012 ) . Readthrough of long-QT syndrome type 1 nonsense mutations rescues function but alters the biophysical properties of the channel . Biochemical Journal vol. 443 , ( 3 ) 635 - 642 .

Telezhkin V, Reilly JM, Thomas AM, Tinker A, Brown DA ( 2012 ) . Structural Requirements of Membrane Phospholipids for M-type Potassium Channel Activation and Binding . Journal of Biological Chemistry vol. 287 , ( 13 ) 10001 - 10012 .

Aziz Q, Thomas AM, Khambra T, Tinker A ( 2012 ) . Regulation of the ATP-sensitive Potassium Channel Subunit, Kir6.2, by a Ca2+-dependent Protein Kinase C . Journal of Biological Chemistry vol. 287 , ( 9 ) 6196 - 6207 .

Gomes J, Finlay M, Ahmed AK, Ciaccio EJ, Asimaki A, Saffitz JE, Quarta G, Nobles M et al. ( 2012 ) . Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study . European Heart Journal vol. 33 , ( 15 ) 1942 - 1953 .

Ang R, Sebastian S, Ludwig A, Birnbaumer L, Tinker A ( 2012 ) . Mice with conditional knockout of Galphai2 in the cardiac pacemaker system exhibit tachycardia with loss of HF power on HRV analysis . CARDIOVASCULAR RESEARCH . vol. 93 , S20 - S20 .

Aziz Q, Khambra T, Sones W, Thomas AM, Kotlikoff M, Tinker A ( 2012 ) . Mouse model for the conditional deletion of the KATP channel subunit Kir6.1 in vascular smooth muscle . CARDIOVASCULAR RESEARCH . vol. 93 , S74 - S74 .

Harmer SC, Mohal JS, Kemp D, Tinker A ( 2012 ) . Rescue of long QT syndrome type 1 nonsense mutations by pharmacologically mediated readthrough . CARDIOVASCULAR RESEARCH . vol. 93 , S105 - S105 .

Thomas AM, Aziz Q, Khambra T, Tinker A ( 2012 ) . The KATP channel subunit, Kir6.2, is regulated by a Ca<SUP>2+</SUP>-dependent isoform of Protein Kinase C . CARDIOVASCULAR RESEARCH . vol. 93 , S65 - S65 .

Ang R, Opel A, Tinker A ( 2012 ) . The Role of Inhibitory G Proteins and Regulators of G Protein Signaling in the in vivo Control of Heart Rate and Predisposition to Cardiac Arrhythmias . Frontiers in Physiology vol. 3 ,

Nobles M, Sebastian S, Tinker A ( 2012 ) . The role of RGS4 in the electrophysiology of atrial cardiac myocytes . CARDIOVASCULAR RESEARCH . vol. 93 , S64 - S64 .

Tinker A, Harmer SC ( 2011 ) . Potassium Channels Regulating the Electrical Activity of the Heart . Translational Vascular Medicine , Springer London

Hothersall JD, Black J, Caddick S, Vinter JG, Tinker A, Baker JR ( 2011 ) . The design, synthesis and pharmacological characterization of novel β₂-adrenoceptor antagonists . British Journal of Pharmacology vol. 164 , ( 2 ) 317 - 331 .

Kapoor RR, Flanagan SE, James CT, McKiernan J, Thomas AM, Harmer SC, Shield JP, Tinker A et al. ( 2011 ) . Hyperinsulinaemic hypoglycaemia and diabetes mellitus due to dominant ABCC8/KCNJ11 mutations . Diabetologia vol. 54 , ( 10 ) 2575 - 2583 .

Schumacher FF, Nobles M, Ryan CP, Smith MEB, Tinker A, Caddick S, Baker JR ( 2011 ) . In Situ Maleimide Bridging of Disulfides and a New Approach to Protein PEGylation . Bioconjugate Chemistry vol. 22 , ( 2 ) 132 - 136 .

Voitychuk OI, Strutynskyi RB, Yagupolskii LM, Tinker A, Moibenko OO, Shuba YM ( 2011 ) . Sarcolemmal cardiac K_ATPchannels as a target for the cardioprotective effects of the fluorine‐containing pinacidil analogue, flocalin . British Journal of Pharmacology vol. 162 , ( 3 ) 701 - 711 .

Thomas AM, Harmer SC, Khambra T, Tinker A ( 2011 ) . Characterization of a Binding Site for Anionic Phospholipids on KCNQ1 . Journal of Biological Chemistry vol. 286 , ( 3 ) 2088 - 2100 .

Bollini S, Pozzobon M, Nobles M, Riegler J, Dong X, Piccoli M, Chiavegato A, Price AN et al. ( 2010 ) . In Vitro and In Vivo Cardiomyogenic Differentiation of Amniotic Fluid Stem Cells . Stem Cell Reviews and Reports vol. 7 , ( 2 ) 364 - 380 .

Ahluwalia J, Tinker A, Clapp LH, Duchen MR, Abramov AY, Pope S, Nobles M, Segal AW ( 2010 ) . Retraction Note: The large-conductance Ca2+-activated K+ channel is essential for innate immunity . Nature vol. 468 , ( 7320 ) 122 - 122 .

Baker JR, Hothersall JD, Fitzmaurice RJ, Tucknott M, Vinter A, Tinker A, Caddick S ( 2010 ) . ChemInform Abstract: An Efficient Asymmetric Synthesis of the Potent β‐Blocker ICI‐118,551 Allows the Determination of Enantiomer Dependency on Biological Activity . ChemInform vol. 41 , ( 43 ) Article chin.201043086 ,

Schwarzer S, Nobles M, Tinker A ( 2010 ) . Do Caveolae Have a Role in the Fidelity and Dynamics of Receptor Activation of G-protein-gated Inwardly Rectifying Potassium Channels? . J BIOL CHEM vol. 285 , ( 36 ) 27817 - 27826 .

Zuberi Z, Nobles M, Sebastian S, Dyson A, Lim SY, Breckenridge R, Birnbaumer L, Tinker A ( 2010 ) . Absence of the Inhibitory G-Protein Gα\n _i2\n Predisposes to Ventricular Cardiac Arrhythmia . Circulation: Arrhythmia and Electrophysiology vol. 3 , ( 4 ) 391 - 400 .

Aziz Q, Thomas A, Khambra T, Tinker A ( 2010 ) . Phenformin has a direct inhibitory effect on the ATP-sensitive potassium channel . European Journal of Pharmacology vol. 634 , ( 1-3 ) 26 - 32 .

Ng KE, Schwarzer S, Duchen MR, Tinker A ( 2010 ) . The Intracellular Localization and Function of the ATP-Sensitive K+ Channel Subunit Kir6.1 . J MEMBRANE BIOL vol. 234 , ( 2 ) 137 - 147 .

Nobles M, Sebastian S, Tinker A ( 2010 ) . HL-1 cells express an inwardly rectifying K+ current activated via muscarinic receptors comparable to that in mouse atrial myocytes . Pflügers Archiv - European Journal of Physiology vol. 460 , ( 1 ) 99 - 108 .

Mashanov GI, Nobles M, Harmer SC, Molloy JE, Tinker A ( 2010 ) . Direct Observation of Individual KCNQ1 Potassium Channels Reveals Their Distinctive Diffusive Behavior . Journal of Biological Chemistry vol. 285 , ( 6 ) 3664 - 3675 .

Harmer SC, Wilson AJ, Aldridge R, Tinker A ( 2010 ) . Mechanisms of disease pathogenesis in long QT syndrome type 5 . American Journal of Physiology-Cell Physiology vol. 298 , ( 2 ) C263 - C273 .

Baker JR, Hothersall JD, Fitzmaurice RJ, Tucknott M, Vinter A, Tinker A, Caddick S ( 2010 ) . An efficient asymmetric synthesis of the potent β-blocker ICI-118,551 allows the determination of enantiomer dependency on biological activity . Chemical Communications vol. 46 , ( 22 ) 3953 - 3953 .

Breckenridge RA, Zuberi Z, Gomes J, Orford R, Dupays L, Felkin LE, Clark JE, Magee AI et al. ( 2009 ) . Overexpression of the transcription factor Hand1 causes predisposition towards arrhythmia in mice . Journal of Molecular and Cellular Cardiology vol. 47 , ( 1 ) 133 - 141 .

Orie NN, Thomas AM, Perrino BA, Tinker A, Clapp LH ( 2009 ) . Ca²⁺/calcineurin regulation of cloned vascular K_ATP channels: crosstalk with the protein kinase A pathway . British Journal of Pharmacology vol. 157 , ( 4 ) 554 - 564 .

Cui Y, Tinker A, Clapp LH ( 2009 ) . Different molecular sites of action for the K_ATP channel inhibitors, PNU‐99963 and PNU‐37883A . British Journal of Pharmacology vol. 139 , ( 1 ) 122 - 128 .

Zuberi Z, Birnbaumer L, Tinker A ( 2008 ) . The role of inhibitory heterotrimeric G proteins in the control of in vivo heart rate dynamics . American Journal of Physiology-Regulatory, Integrative and Comparative Physiology vol. 295 , ( 6 ) R1822 - R1830 .

Campanella M, Casswell E, Chong S, Farah Z, Wieckowski MR, Abramov AY, Tinker A, Duchen MR ( 2008 ) . Regulation of Mitochondrial Structure and Function by the F1Fo-ATPase Inhibitor Protein, IF1 . Cell Metabolism vol. 8 , ( 1 ) 13 - 25 .

Campanella M, Tan C, Abramov A, Tinker A, Duchen M ( 2008 ) . S12/4 Mitochondria as ATP consumers: the cell biology of the endogenous inhibitory protein, IF1 . Biochimica et Biophysica Acta (BBA) - Bioenergetics vol. 1777 , S76 - S76 .

Quinn KV, Behe P, Tinker A ( 2008 ) . Monitoring changes in membrane phosphatidylinositol 4,5‐bisphosphate in living cells using a domain from the transcription factor tubby . The Journal of Physiology vol. 586 , ( 12 ) 2855 - 2871 .

Farzaneh T, Tinker A ( 2008 ) . Differences in the mechanism of metabolic regulation of ATP-sensitive K+ channels containing Kir6.1 and Kir6.2 subunits . Cardiovascular Research vol. 79 , ( 4 ) 621 - 631 .

BRECKENRIDGE R, ZUBERI Z, FELKIN L, BIRKS E, BARTON P, TINKER A, MOHUN T ( 2008 ) . Overexpression of the transcription factor Hand1 causes sudden cardiac death in mice . European Journal of Heart Failure Supplements vol. 7 , 109 - 109 .

Thomas AM, Tinker A ( 2008 ) . Determination of Phosphoinositide Binding to K+ Channel Subunits Using a Protein—Lipid Overlay Assay . 103 - 111 .

Harmer SC, Tinker A ( 2007 ) . The role of abnormal trafficking of KCNE1 in long QT syndrome 5 . Biochemical Society Transactions vol. 35 , ( 5 ) 1074 - 1076 .

Falcetti E, Flavell DM, Staels B, Tinker A, Haworth SG, Clapp LH ( 2007 ) . IP receptor-dependent activation of PPARγ by stable prostacyclin analogues . Biochemical and Biophysical Research Communications vol. 360 , ( 4 ) 821 - 827 .

Brown DA, Hughes SA, Marsh SJ, Tinker A ( 2007 ) . Regulation of M(Kv7.2/7.3) channels in neurons by PIP₂and products of PIP₂hydrolysis: significance for receptor‐mediated inhibition . The Journal of Physiology . vol. 582 , 917 - 925 .

Muzyamba M, Farzaneh T, Behe P, Thomas A, Christesen HBT, Brusgaard K, Hussain K, Tinker A ( 2007 ) . Complex <i>ABCC8</i> DNA variations in congenital hyperinsulinism: lessons from functional studies . Clinical Endocrinology vol. 67 , ( 1 ) 115 - 124 .

Hughes S, Marsh SJ, Tinker A, Brown DA ( 2007 ) . PIP2-dependent inhibition of M-type (Kv7.2/7.3) potassium channels: direct on-line assessment of PIP2 depletion by Gq-coupled receptors in single living neurons . Pflügers Archiv - European Journal of Physiology vol. 455 , ( 1 ) 115 - 124 .

Tennant BP, Cui Y, Tinker A, Clapp LH ( 2007 ) . Functional Expression of Inward Rectifier Potassium Channels in Cultured Human Pulmonary Smooth Muscle Cells: Evidence for a Major Role of Kir2.4 Subunits . Journal of Membrane Biology vol. 213 , ( 1 ) 19 - 29 .

Thomas AM, Brown SG, Leaney JL, Tinker A ( 2006 ) . Differential Phosphoinositide Binding to Components of the G Protein-Gated K+ Channel . Journal of Membrane Biology vol. 211 , ( 1 ) 43 - 53 .

Kang Y, Ng B, Leung Y-M, He Y, Xie H, Lodwick D, Norman RI, Tinker A et al. ( 2006 ) . Syntaxin-1A Actions on Sulfonylurea Receptor 2A Can Block Acidic pH-induced Cardiac KATP Channel Activation . Journal of Biological Chemistry vol. 281 , ( 28 ) 19019 - 19028 .

Tinker A ( 2006 ) . The selective interactions and functions of regulators of G-protein signalling . Seminars in Cell &amp; Developmental Biology vol. 17 , ( 3 ) 377 - 382 .

Nobles M, Benians A, Tinker A ( 2005 ) . Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells . Proceedings of the National Academy of Sciences vol. 102 , ( 51 ) 18706 - 18711 .

Brown SG, Thomas A, Dekker LV, Tinker A, Leaney JL ( 2005 ) . PKC-δ sensitizes Kir3.1/3.2 channels to changes in membrane phospholipid levels after M₃ receptor activation in HEK-293 cells . American Journal of Physiology-Cell Physiology vol. 289 , ( 3 ) C543 - C556 .

WILSON A, QUINN K, GRAVES F, BITNERGLINDZICZ M, TINKER A ( 2005 ) . Abnormal KCNQ1 trafficking influences disease pathogenesis in hereditary long QT syndromes (LQT1) . Cardiovascular Research vol. 67 , ( 3 ) 476 - 486 .

Benians A, Nobles M, Hosny S, Tinker A ( 2005 ) . Regulators of G-protein Signaling Form a Quaternary Complex with the Agonist, Receptor, and G-protein . Journal of Biological Chemistry vol. 280 , ( 14 ) 13383 - 13394 .

Morrissey A, Rosner E, Lanning J, Parachuru L, Dhar Chowdhury P, Han S, Lopez G, Tong X et al. ( 2005 ) . Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature . BMC Physiology vol. 5 , ( 1 ) Article 1 ,

Benians A, Nobles M, Tinker A ( 2004 ) . Participation of RGS8 in the ternary complex of agonist, receptor and G-protein . Biochemical Society Transactions . vol. 32 , 1045 - 1047 .

Leaney JL, Dekker LV, Tinker A ( 2004 ) . Regulation of a G protein‐gated inwardly rectifying K⁺ channel by a Ca²⁺‐independent protein kinase C . The Journal of Physiology vol. 534 , ( 2 ) 367 - 379 .

Leaney JL, Benians A, Brown S, Nobles M, Kelly D, Tinker A ( 2004 ) . Rapid desensitization of G protein-gated inwardly rectifying K⁺ currents is determined by G protein cycle . American Journal of Physiology-Cell Physiology vol. 287 , ( 1 ) C182 - C191 .

Quinn KV, Giblin JP, Tinker A ( 2004 ) . Multisite Phosphorylation Mechanism for Protein Kinase A Activation of the Smooth Muscle ATP-Sensitive K\n ⁺\n Channel . Circulation Research vol. 94 , ( 10 ) 1359 - 1366 .

Ahluwalia J, Tinker A, Clapp LH, Duchen MR, Abramov AY, Pope S, Nobles M, Segal AW ( 2004 ) . The large-conductance Ca2+-activated K+ channel is essential for innate immunity . Nature vol. 427 , ( 6977 ) 853 - 858 .

Quinn KV, Cui Y, Giblin JP, Clapp LH, Tinker A ( 2003 ) . Do Anionic Phospholipids Serve as Cofactors or Second Messengers for the Regulation of Activity of Cloned ATP-Sensitive K\n ⁺\n Channels? . Circulation Research vol. 93 , ( 7 ) 646 - 655 .

Benians A, Leaney JL, Tinker A ( 2003 ) . Agonist unbinding from receptor dictates the nature of deactivation kinetics of G protein-gated K\n ⁺\n channels . Proceedings of the National Academy of Sciences vol. 100 , ( 10 ) 6239 - 6244 .

Benians A, Leaney JL, Milligan G, Tinker A ( 2003 ) . The Dynamics of Formation and Action of the Ternary Complex Revealed in Living Cells Using a G-protein-gated K+ Channel as a Biosensor . Journal of Biological Chemistry vol. 278 , ( 12 ) 10851 - 10858 .

Giblin JP, Quinn K, Tinker A ( 2002 ) . The cytoplasmic C‐terminus of the sulfonylurea receptor is important for K_ATP channel function but is not key for complex assembly or trafficking . European Journal of Biochemistry vol. 269 , ( 21 ) 5303 - 5313 .

Lawrence KM, Chanalaris A, Scarabelli T, Hubank M, Pasini E, Townsend PA, Comini L, Ferrari R et al. ( 2002 ) . K\n _ATP\n Channel Gene Expression Is Induced by Urocortin and Mediates Its Cardioprotective Effect . Circulation vol. 106 , ( 12 ) 1556 - 1562 .

Tinker A ( 2002 ) . The assembly and targeting of potassium channels . Receptor and Ion-Channel TraffickingCell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels , Oxford University Press

Leaney JL, Benians A, Graves FM, Tinker A ( 2002 ) . A Novel Strategy to Engineer Functional Fluorescent Inhibitory G-protein α Subunits . Journal of Biological Chemistry vol. 277 , ( 32 ) 28803 - 28809 .

Giblin JP, Cui Y, Clapp LH, Tinker A ( 2002 ) . Assembly Limits the Pharmacological Complexity of ATP-sensitive Potassium Channels . Journal of Biological Chemistry vol. 277 , ( 16 ) 13717 - 13723 .

Clapp LH, Finney P, Turcato S, Tran S, Rubin LJ, Tinker A ( 2002 ) . Differential Effects of Stable Prostacyclin Analogs on Smooth Muscle Proliferation and Cyclic AMP Generation in Human Pulmonary Artery . American Journal of Respiratory Cell and Molecular Biology vol. 26 , ( 2 ) 194 - 201 .

Cui Y, Tran S, Tinker A, Clapp LH ( 2002 ) . The Molecular Composition of K_ATP Channels in Human Pulmonary Artery Smooth Muscle Cells and Their Modulation by Growth . American Journal of Respiratory Cell and Molecular Biology vol. 26 , ( 1 ) 135 - 143 .

Huang L ( 2001 ) . A spectrum of functional effects for disease causing mutations in the Jervell and Lange-Nielsen syndrome . Cardiovascular Research vol. 51 , ( 4 ) 670 - 680 .

Cui Y, Giblin JP, Clapp LH, Tinker A ( 2001 ) . A mechanism for ATP-sensitive potassium channel diversity: Functional coassembly of two pore-forming subunits . Proceedings of the National Academy of Sciences vol. 98 , ( 2 ) 729 - 734 .

Graves FM, Tinker A ( 2000 ) . Functional Expression of the Pore Forming Subunit of the ATP-Sensitive Potassium Channel in Saccharomyces cerevisiae . Biochemical and Biophysical Research Communications vol. 272 , ( 2 ) 403 - 409 .

Leaney JL, Tinker A ( 2000 ) . The role of members of the pertussis toxin-sensitive family of G proteins in coupling receptors to the activation of the G protein-gated inwardly rectifying potassium channel . Proceedings of the National Academy of Sciences vol. 97 , ( 10 ) 5651 - 5656 .

Leaney JL, Milligan G, Tinker A ( 2000 ) . The G Protein α Subunit Has a Key Role in Determining the Specificity of Coupling to, but Not the Activation of, G Protein-gated Inwardly Rectifying K+ Channels . Journal of Biological Chemistry vol. 275 , ( 2 ) 921 - 929 .

Giblin JP, Leaney JL, Tinker A ( 1999 ) . The Molecular Assembly of ATP-sensitive Potassium Channels . Journal of Biological Chemistry vol. 274 , ( 32 ) 22652 - 22659 .

Tinker A, Jan LY ( 1999 ) . Chapter 9 The Assembly of Inwardly Rectifying Potassium Channels . 143 - 158 .

H L, Tinker A ( 1998 ) . Potassium channels in the vasculature . Current Opinion in Nephrology and Hypertension vol. 7 , ( 1 ) 83 - 98 .

Welch W, Williams AJ, Tinker A, Mitchell KE, Deslongchamps P, Lamothe J, Gerzon K, Bidasee KR et al. ( 1997 ) . Structural Components of Ryanodine Responsible for Modulation of Sarcoplasmic Reticulum Calcium Channel Function . Biochemistry vol. 36 , ( 10 ) 2939 - 2950 .

Tinker A, Jan YN, Jan LY ( 1996 ) . Regions Responsible for the Assembly of Inwardly Rectifying Potassium Channels . Cell vol. 87 , ( 5 ) 857 - 868 .

Tinker A, Sutko JL, Ruest L, Deslongchamps P, Welch W, Airey JA, Gerzon K, Bidasee KR et al. ( 1996 ) . Electrophysiological effects of ryanodine derivatives on the sheep cardiac sarcoplasmic reticulum calcium-release channel . Biophysical Journal vol. 70 , ( 5 ) 2110 - 2119 .

Tinker A, Williams AJ ( 1995 ) . Measuring the length of the pore of the sheep cardiac sarcoplasmic reticulum calcium-release channel using related trimethylammonium ions as molecular calipers . Biophysical Journal vol. 68 , ( 1 ) 111 - 120 .

Lindsay AR, Tinker A, Williams AJ ( 1994 ) . How does ryanodine modify ion handling in the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel? . The Journal of general physiology vol. 104 , ( 3 ) 425 - 447 .

Tinker A, Williams AJ ( 1993 ) . Probing the structure of the conduction pathway of the sheep cardiac sarcoplasmic reticulum calcium-release channel with permeant and impermeant organic cations . The Journal of general physiology vol. 102 , ( 6 ) 1107 - 1129 .

Tinker A, Lindsay ARG, Williams AJ ( 1993 ) . Cation conduction in the calcium release channel of the cardiac sarcoplasmic reticulum under physiological and pathophysiological conditions . Cardiovascular Research vol. 27 , ( 10 ) 1820 - 1825 .

Tinker A, Williams AJ ( 1993 ) . Using large organic cations to probe the nature of ryanodine modification in the sheep cardiac sarcoplasmic reticulum calcium release channel . Biophysical Journal vol. 65 , ( 4 ) 1678 - 1683 .

Tinker A, Williams AJ ( 1993 ) . Charged local anesthetics block ionic conduction in the sheep cardiac sarcoplasmic reticulum calcium release channel . Biophysical Journal vol. 65 , ( 2 ) 852 - 864 .

Tinker A, Lindsay AR, Williams AJ ( 1992 ) . A model for ionic conduction in the ryanodine receptor channel of sheep cardiac muscle sarcoplasmic reticulum . The Journal of general physiology vol. 100 , ( 3 ) 495 - 517 .

Tinker A, Williams AJ ( 1992 ) . Divalent cation conduction in the ryanodine receptor channel of sheep cardiac muscle sarcoplasmic reticulum . The Journal of general physiology vol. 100 , ( 3 ) 479 - 493 .

Tinker A, Lindsay AR, Williams AJ ( 1992 ) . Large tetraalkyl ammonium cations produce a reduced conductance state in the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel . Biophysical Journal vol. 61 , ( 5 ) 1122 - 1132 .

Tinker A, Lindsay AG, Williams A ( 1992 ) . Block of the sheep cardiac sarcoplasmic reticulum Ca2+-release channel by tetra-alkyl ammonium cations . The Journal of Membrane Biology vol. 127 , ( 2 )

Tinker A, Lindsay ARG, Williams AJ ( 1992 ) . A model for ionic conduction in the sheep cardiac ryanodine receptor-channel . Journal of Physiology . vol. 446 ,