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  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: DR Muriel Nobles

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Tsisanova E, Nobles M, Sebastian S, Ng K-E, Thomas A, Weinstein LS, Munroe PB, Tinker A ( 2024 ) . The ric-8b protein (resistance to inhibitors of cholinesterase 8b) is key to preserving contractile function in the adult heart . Journal of Biological Chemistry vol. 300 , ( 7 )
Zawada D, Kornherr J, Meier AB, Santamaria G, Dorn T, Nowak-Imialek M, Ortmann D, Zhang F et al. ( 2023 ) . Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools . Nature Communications vol. 14 , ( 1 )
Morera C, Kim J, Paredes-Redondo A, Nobles M, Rybin D, Moccia R, Kowala A, Meng J et al. ( 2022 ) . CRISPR-mediated correction of skeletal muscle Ca2+ handling in a novel DMD patient-derived pluripotent stem cell model . Neuromuscular Disorders vol. 32 , ( 11-12 ) 908 - 922 .
Sebastian S, Nobles M, Tsisanova E, Ludwig A, Munroe PB, Tinker A ( 2021 ) . The role of resistance to inhibitors of cholinesterase 8b in the control of heart rate . Physiological Genomics vol. 53 , ( 4 ) 150 - 159 .
Aziz Q, Nobles M, Tinker A ( 2020 ) . Acute Isolation of Cells from Murine Sino-atrial Node . Bio-protocol vol. 10 , ( 1 )
Aziz Q, Nobles M, Tinker A ( 2020 ) . Whole-cell and Perforated Patch-clamp Recordings from Acutely-isolated Murine Sino-atrial Node Cells . Bio-protocol vol. 10 , ( 1 )
Thomas AM, Cabrera CP, Finlay M, Lall K, Nobles M, Schilling RJ, Wood K, Mein CA et al. ( 2019 ) . Differentially expressed genes for atrial fibrillation identified by RNA sequencing from paired human left and right atrial appendages . Physiological Genomics vol. 51 , ( 8 ) 323 - 332 .
Tinker A, Finlay M, Nobles M, Opel A ( 2018 ) . Erratum to “The contribution of pathways initiated via the Gq\11 G-protein family to atrial fibrillation” [Pharmacol. Res. 105 (2016) 54–61] . Pharmacological Research vol. 129 ,
Nobles M, Montaigne D, Sebastian S, Birnbaumer L, Tinker A ( 2018 ) . Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K+ currents in adult murine atria . American Journal of Physiology - Cell Physiology vol. 314 , ( 5 ) c616 - c626 .
Miller DC, Harmer SC, Poliandri A, Nobles M, Edwards EC, Ware JS, Sharp TV, McKay TR et al. ( 2017 ) . Ajmaline blocks I Na and I Kr without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters . Stem Cell Research vol. 25 , 233 - 244 .
Poliandri A, Miller D, Howard S, Nobles M, Ruiz-Babot G, Harmer S, Tinker A, McKay T et al. ( 2017 ) . Generation of kisspeptin-responsive GnRH neurons from human pluripotent stem cells . Molecular and Cellular Endocrinology vol. 447 , 12 - 22 .
Tinker A, Finlay M, Nobles M, Opel A ( 2016 ) . The contribution of pathways initiated via the Gq\11 G-protein family to atrial fibrillation . Pharmacological Research vol. 105 , 54 - 61 .
Richards DA, Fletcher SA, Nobles M, Kossen H, Tedaldi L, Chudasama V, Tinker A, Baker JR ( 2016 ) . Photochemically re-bridging disulfide bonds and the discovery of a thiomaleimide mediated photodecarboxylation of C-terminal cysteines . Organic & Biomolecular Chemistry vol. 14 , ( 2 ) 455 - 459 .
Opel A, Nobles M, Montaigne D, Finlay M, Anderson N, Breckenridge R, Tinker A ( 2015 ) . Absence of the Regulator of G-protein Signaling, RGS4, Predisposes to Atrial Fibrillation and Is Associated with Abnormal Calcium Handling* . Journal of Biological Chemistry vol. 290 , ( 31 ) 19233 - 19244 .
Fletcher SA, Sin PKB, Nobles M, Årstad E, Tinker A, Baker JR ( 2015 ) . A dual optical and nuclear imaging reagent for peptide labelling via disulfide bridging . Organic & Biomolecular Chemistry vol. 13 , ( 37 ) 9559 - 9563 .
Gomes J, Finlay M, Ahmed AK, Ciaccio EJ, Asimaki A, Saffitz JE, Quarta G, Nobles M et al. ( 2012 ) . Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study . European Heart Journal vol. 33 , ( 15 ) 1942 - 1953 .
Nobles M, Sebastian S, Tinker A ( 2012 ) . The role of RGS4 in the electrophysiology of atrial cardiac myocytes . CARDIOVASCULAR RESEARCH . vol. 93 , S64 - S64 .
Schumacher FF, Nobles M, Ryan CP, Smith MEB, Tinker A, Caddick S, Baker JR ( 2011 ) . In Situ Maleimide Bridging of Disulfides and a New Approach to Protein PEGylation . Bioconjugate Chemistry vol. 22 , ( 2 ) 132 - 136 .
Bollini S, Pozzobon M, Nobles M, Riegler J, Dong X, Piccoli M, Chiavegato A, Price AN et al. ( 2010 ) . In Vitro and In Vivo Cardiomyogenic Differentiation of Amniotic Fluid Stem Cells . Stem Cell Reviews and Reports vol. 7 , ( 2 ) 364 - 380 .
Ahluwalia J, Tinker A, Clapp LH, Duchen MR, Abramov AY, Pope S, Nobles M, Segal AW ( 2010 ) . Retraction Note: The large-conductance Ca2+-activated K+ channel is essential for innate immunity . Nature vol. 468 , ( 7320 ) 122 - 122 .
Schwarzer S, Nobles M, Tinker A ( 2010 ) . Do Caveolae Have a Role in the Fidelity and Dynamics of Receptor Activation of G-protein-gated Inwardly Rectifying Potassium Channels?* . Journal of Biological Chemistry vol. 285 , ( 36 ) 27817 - 27826 .
Zuberi Z, Nobles M, Sebastian S, Dyson A, Lim SY, Breckenridge R, Birnbaumer L, Tinker A ( 2010 ) . Absence of the Inhibitory G-Protein G&agr;i2 Predisposes to Ventricular Cardiac Arrhythmia . Circulation Arrhythmia and Electrophysiology vol. 3 , ( 4 ) 391 - 400 .
Nobles M, Sebastian S, Tinker A ( 2010 ) . HL-1 cells express an inwardly rectifying K+ current activated via muscarinic receptors comparable to that in mouse atrial myocytes . Pflügers Archiv - European Journal of Physiology vol. 460 , ( 1 ) 99 - 108 .
Mashanov GI, Nobles M, Harmer SC, Molloy JE, Tinker A ( 2009 ) . Direct Observation of Individual KCNQ1 Potassium Channels Reveals Their Distinctive Diffusive Behavior2 . Journal of Biological Chemistry vol. 285 , ( 6 ) 3664 - 3675 .
Hobbs AJ, Gane P, Lumsden N, Nobles M, Rebstock A-S, Simone M, Villar I, Worthington R et al. ( 2009 ) . Design and development of novel non-peptide agonists at natriuretic peptide receptor-C . FASEB JOURNAL vol. 23 ,
Villar IC, Panayiotou CM, Sheraz A, Madhani M, Scotland RS, Nobles M, Kemp-Harper B, Ahluwalia A et al. ( 2007 ) . Definitive role for natriuretic peptide receptor-C in mediating the vasorelaxant activity of C-type natriuretic peptide and endothelium-derived hyperpolarising factor . CARDIOVASC RES vol. 74 , ( 3 ) 515 - 525 .
Nobles M, Benians A, Tinker A ( 2005 ) . Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells . Proceedings of the National Academy of Sciences of the United States of America vol. 102 , ( 51 ) 18706 - 18711 .
Basoni C, Nobles M, Grimshaw A, Desgranges C, Davies D, Perretti M, Kramer IM, Genot E ( 2005 ) . Inhibitory control of TGF-beta 1 on the activation of Rap1, CD11b, and transendothelial migration of leukocytes . FASEB J vol. 19 , ( 3 ) 822 - + .
Benians A, Nobles M, Hosny S, Tinker A ( 2005 ) . Regulators of G-protein Signaling Form a Quaternary Complex with the Agonist, Receptor, and G-protein A NOVEL EXPLANATION FOR THE ACCELERATION OF SIGNALING ACTIVATION KINETICS* . Journal of Biological Chemistry vol. 280 , ( 14 ) 13383 - 13394 .
Benians A, Nobles M, Tinker A ( 2004 ) . Participation of RGS8 in the ternary complex of agonist, receptor and G-protein . Biochemical Society Transactions . vol. 32 , 1045 - 1047 .
Leaney JL, Benians A, Brown S, Nobles M, Kelly D, Tinker A ( 2004 ) . Rapid desensitization of G protein-gated inwardly rectifying K+ currents is determined by G protein cycle . American Journal of Physiology - Cell Physiology vol. 287 , ( 1 ) c182 - c191 .
NOBLES M, REVEST PA, COURAUD PO, ABBOTT NJ ( 1995 ) . CHARACTERISTICS OF NUCLEOTIDE RECEPTORS THAT CAUSE ELEVATION OF CYTOPLASMIC CALCIUM IN IMMORTALIZED RAT-BRAIN ENDOTHELIAL-CELLS (RBE4) AND IN PRIMARY CULTURES . BRIT J PHARMACOL vol. 115 , ( 7 ) 1245 - 1252 .
NOBLES M, REVEST PA, COURAUD PO, ABBOTT NJ ( 1994 ) . EVIDENCE FOR NUCLEOTIDE RECEPTORS IN IMMORTALIZED RAT-BRAIN CAPILLARY ENDOTHELIAL-CELLS IN CULTURE . J PHYSIOL-LONDON vol. 475P , P64 - P64 .
Morera C, Kim J, Paredes-Redondo A, Nobles M, Rybin D, Moccia R, Kowala A, Meng J et al. . CRISPR-mediated correction of skeletal muscle Ca2+ handling in a novel DMD patient-derived pluripotent stem cell model .
Zawada D, Kornherr J, Meier AB, Santamaria G, Dorn T, Ortmann D, Lachmann M, Ortiz M et al. . Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools .
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