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Research
  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: DR Alison Thomas

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Tsisanova E, Nobles M, Sebastian S, Ng K-E, Thomas A, Weinstein LS, Munroe PB, Tinker A ( 2024 ) . The ric-8b protein (resistance to inhibitors of cholinesterase 8b) is key to preserving contractile function in the adult heart . Journal of Biological Chemistry vol. 300 , ( 7 )
Rodriguez A, Villar D, Frost S, Tinker A, Thomas A ( 2023 ) . BS56 An epigenomic investigation of atrial fibrillation in a paired left and right atrial cohort . Conference: Basic Sciencea285.1 - a2a285 .
Thomas AM, Cabrera CP, Finlay M, Lall K, Nobles M, Schilling RJ, Wood K, Mein CA et al. ( 2019 ) . Differentially expressed genes for atrial fibrillation identified by RNA sequencing from paired human left and right atrial appendages . Physiological Genomics vol. 51 , ( 8 ) 323 - 332 .
Nessa A, Aziz QH, Thomas AM, Harmer SC, Tinker A, Hussain K ( 2015 ) . Molecular mechanisms of congenital hyperinsulinism due to autosomal dominant mutations in ABCC8 . Human Molecular Genetics vol. 24 , ( 18 ) 5142 - 5153 .
Aziz Q, Thomas AM, Gomes J, Ang R, Sones WR, Li Y, Ng K-E, Gee L et al. ( 2014 ) . The ATP-Sensitive Potassium Channel Subunit, Kir6.1, in Vascular Smooth Muscle Plays a Major Role in Blood Pressure Control . Hypertension vol. 64 , ( 3 ) 523 - 529 .
Tinker A, Aziz Q, Thomas A ( 2014 ) . The role of ATP-sensitive potassium channels in cellular function and protection in the cardiovascular system . Br J Pharmacol vol. 171 , ( 1 ) 12 - 23 .
Telezhkin V, Thomas AM, Harmer SC, Tinker A, Brown DA ( 2013 ) . A basic residue in the proximal C-terminus is necessary for efficient activation of the M-channel subunit Kv7.2 by PI(4,5)P2 . Pflügers Archiv - European Journal of Physiology vol. 465 , ( 7 ) 945 - 953 .
Telezhkin V, Reilly JM, Thomas AM, Tinker A, Brown DA ( 2012 ) . Structural Requirements of Membrane Phospholipids for M-type Potassium Channel Activation and Binding* . Journal of Biological Chemistry vol. 287 , ( 13 ) 10001 - 10012 .
Aziz Q, Khambra T, Sones W, Thomas AM, Kotlikoff M, Tinker A ( 2012 ) . Mouse model for the conditional deletion of the KATP channel subunit Kir6.1 in vascular smooth muscle . CARDIOVASCULAR RESEARCH . vol. 93 , S74 - S74 .
Thomas AM, Aziz Q, Khambra T, Tinker A ( 2012 ) . The KATP channel subunit, Kir6.2, is regulated by a Ca<SUP>2+</SUP>-dependent isoform of Protein Kinase C . CARDIOVASCULAR RESEARCH . vol. 93 , S65 - S65 .
Aziz Q, Thomas AM, Khambra T, Tinker A ( 2011 ) . Regulation of the ATP-sensitive Potassium Channel Subunit, Kir6.2, by a Ca2+-dependent Protein Kinase C* . Journal of Biological Chemistry vol. 287 , ( 9 ) 6196 - 6207 .
Kapoor RR, Flanagan SE, James CT, McKiernan J, Thomas AM, Harmer SC, Shield JP, Tinker A et al. ( 2011 ) . Hyperinsulinaemic hypoglycaemia and diabetes mellitus due to dominant ABCC8/KCNJ11 mutations . Diabetologia vol. 54 , ( 10 )
Thomas AM, Harmer SC, Khambra T, Tinker A ( 2010 ) . Characterization of a Binding Site for Anionic Phospholipids on KCNQ1* . Journal of Biological Chemistry vol. 286 , ( 3 ) 2088 - 2100 .
Aziz Q, Thomas A, Khambra T, Tinker A ( 2010 ) . Phenformin has a direct inhibitory effect on the ATP-sensitive potassium channel . European Journal of Pharmacology vol. 634 , ( 1-3 ) 26 - 32 .
Orie N, Thomas A, Perrino B, Tinker A, Clapp L ( 2009 ) . Ca2+/calcineurin regulation of cloned vascular KATP channels: crosstalk with the protein kinase A pathway . British Journal of Pharmacology vol. 157 , ( 4 ) 554 - 564 .
Thomas AM, Tinker A ( 2008 ) . Determination of Phosphoinositide Binding to K+ Channel Subunits Using a Protein—Lipid Overlay Assay . Methods in Molecular Biology vol. 491 , 103 - 111 .
Muzyamba M, Farzaneh T, Behe P, Thomas A, Christesen HBT, Brusgaard K, Hussain K, Tinker A ( 2007 ) . Complex ABCC8 DNA variations in congenital hyperinsulinism: lessons from functional studies . Clinical Endocrinology vol. 67 , ( 1 ) 115 - 124 .
Brown SG, Thomas A, Dekker LV, Tinker A, Leaney JL ( 2005 ) . PKC-δ sensitizes Kir3.1/3.2 channels to changes in membrane phospholipid levels after M3 receptor activation in HEK-293 cells . American Journal of Physiology - Cell Physiology vol. 289 , ( 3 ) c543 - c556 .
Rodriguez A, Frost S, Thomas AM, Fernandez-Aroca D, Choudhury J, Tikkas G, Tinker A, Munroe PB et al. . An epigenomic investigation of atrial fibrillation in a matched left and right atrial human cohort .
Thomas AM, Chiong IN, Neves JF, Tinker A, Denk F, Fedele L . Generation of parasympathetic neurons from hiPSC that reproduce the electrophysiological properties of native neurons and modulate the activity of hiPSC-atrial cardiomyocytes .
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