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  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: DR Mohey Elshikh

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Aly NAR, Rizk S, Enein AA, Desoukey NE, Zawam H, Ahmed M, Shikh MEE, Pitzalis C ( 2022 ) . The role of lymphoid tissue SPARC in the pathogenesis and response to treatment of multiple myeloma . Frontiers in Oncology vol. 12 ,
Shikh MEME, Sayed RE, Aly NAR, Prediletto E, Hands R, Fossati-Jimack L, Bombardieri M, Lewis MJ et al. ( 2022 ) . Follicular dendritic cell differentiation is associated with distinct synovial pathotype signatures in rheumatoid arthritis . Frontiers in Medicine vol. 9 ,
Elsayed R, Kurago Z, Cutler CW, Gerber J, Celis E, Sultan H, Elashiry M, Sun C et al. ( 2020 ) . Role of dendritic cell‐mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw . The FASEB Journal vol. 34 , ( 2 ) 2595 - 2608 .
El Shikh MEM, El Sayed R, Nerviani A, Goldmann K, John CR, Hands R, Fossati-Jimack L, Lewis MJ et al. ( 2019 ) . Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis . Journal of Autoimmunity
Rivellese F, Mauro D, Nerviani A, Pagani S, Fossati-Jimack L, Messemaker T, Kurreeman FAS, Toes REM et al. ( 2018 ) . Mast cells in early rheumatoid arthritis associate with disease severity and support B cell autoantibody production . Annals of the Rheumatic Diseases vol. 77 , ( 12 ) 1773 - 1781 .
Shikh ME, Sayed RE, Fossati-Jimack L, Pitzalis C ( 2018 ) . O001 Lymphoid tissue macrophages express peptidylarginine deiminase 2 and 4: new implications in citrullination and anti-citrulline antibodies production in autoimmune arthritis . Annals of the Rheumatic Diseases . vol. 77 ,
Elsayed R, Celis E, Sultan H, Cutler C, Elashiry M, Awad M, Elsalanty M ( 2018 ) . Impaired Dendritic Cell Function and Bacterial Load Increase in the Oral Microenvironment as Contributing Factors to the Induction of MRONJ . JOURNAL OF BONE AND MINERAL RESEARCH . vol. 33 , 22 - 22 .
Altamimi A-MS, Alafeefy AM, Balode A, Vozny I, Pustenko A, Shikh MEE, Alasmary FAS, Žalubovskis R ( 2017 ) . Symmetric molecules with 1,4-triazole moieties as potent inhibitors of tumour-associated lactate dehydrogenase-A . Journal of Enzyme Inhibition and Medicinal Chemistry vol. 33 , Article 1 , 147 - 150 .
Lownik JC, Luker AJ, Damle SR, Cooley LF, El Sayed R, Hutloff A, Pitzalis C, Martin RK et al. ( 2017 ) . ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses . The Journal of Immunology vol. 199 , ( 7 ) 2305 - 2315 .
El Shikh MEM, El Sayed R, Pitzalis C ( 2017 ) . Isolation and Characterization of Mouse and Human Follicular Dendritic Cells . Methods Mol Biol vol. 1623 , 113 - 123 .
Rivellese F, Humby F, Kelly S, Nerviani A, Mauro D, Rocher-Ros V, El Shikh ME, de Paulis A et al. ( 2016 ) . SYNOVIAL MAST CELLS CORRELATE WITH LOCAL AND SYSTEMIC INFLAMMATION AND ARE FUNCTIONALLY ASSOCIATED WITH ECTOPIC LYMPHOID STRUCTURES IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS . Presented at: EULAR 2016 ,
Cooley LF, El Shikh ME, Li W, Keim RC, Zhang Z ( 2016 ) . Impaired immunological synapse in sperm associated antigen 6 (SPAG6) deficient mice . Sci Rep vol. 6 , 25840 - 25840 .
Llibre A, López-Macías C, Marafioti T, Mehta H, Partridge A, Kanzig C, Rivellese F, Galson JD et al. ( 2016 ) . LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation . J Immunol vol. 196 , ( 5 ) 2085 - 2094 .
Cooley LF, Martin RK, Zellner HB, Irani A-M, Uram-Tuculescu C ( 2015 ) . Increased B Cell ADAM10 in Allergic Patients and Th2 Prone Mice . PLoS One vol. 10 , ( 5 ) e0124331 - e0124331 .
Shikh MEME ( 2014 ) . SP0011 Follicular Dendritic Cells in Immunity and Autoimmunity . Annals of the Rheumatic Diseases . vol. 73 ,
Al-Mousawi AZ, El Shikh MEM, Pitzalis C ( 2014 ) . IMMUNE COMPLEX RETENTION BY SYNOVIAL FIBROBLASTS IN RHEUMATOID ARTHRITIS . RHEUMATOLOGY . vol. 53 , 84 - 84 .
Folgosa L, Zellner HB ( 2013 ) . Disturbed follicular architecture in B cell A disintegrin and metalloproteinase (ADAM)10 knockouts is mediated by compensatory increases in ADAM17 and TNF-α shedding . J Immunol vol. 191 , ( 12 ) 5951 - 5958 .
El Shikh ME, Kmieciak M, Manjili MH, Szakal AK, Pitzalis C, Tew JG ( 2013 ) . Multi-therapeutic potential of autoantibodies induced by immune complexes trapped on follicular dendritic cells . Hum Vaccin Immunother vol. 9 , ( 11 ) 2434 - 2444 .
Folgosa L, El Shikh M ( 2013 ) . New implications of ADAMs in TNF{alpha} related diseases: ADAM10 deficient B cells exhibit increased ADAM17 and TNF{alpha} (P4388) . The Journal of Immunology vol. 190 , ( Meeting Abstracts 1 )
Folgosa L, Conrad D ( 2013 ) . New implications of ADAMs in TNFα related diseases: ADAM10 deficient B cells exhibit increased ADAM17 and TNFα (P4388) . The Journal of Immunology vol. 190 , ( Supplement_1 ) 52.14 - 52.14 .
El Shikh ME, Biggioggero M, El Sayed R, Kmieciak M, Manjili M, Szakal A, Meroni PL, Pitzalis C et al. ( 2013 ) . REGULATION OF AUTO-ANTIBODY PRODUCTION BY AUTO-IMMUNE COMPLEXES ON FOLLICULAR DENDRITIC CELLS . ANNALS OF THE RHEUMATIC DISEASES vol. 71 , 129 - 129 .
SUKUMAR S, EL SHIKH MEM, TEW JG, SANCHEZ-SCHMITZ G, MOSQUERA L, LI C, KACHURIN AM, HIGBEE R et al. ( 2012 ) . Methods of evaluating an immune response to an antigen . no. 13167115 ,
TEW J, EL SHIKH MEM, SINGH I, MISHKIN E, SONG H ( 2012 ) . MODELS FOR VACCINE ASSESSMENT . no. 07872536.3 ,
El Shikh MEM, El Sayed R, Szakal AK, Tew JG, Wittman V ( 2012 ) . Rapid generation of T cell-independent antibody responses to T cell-dependent antigens . no. EP20110185845 ,
Tew JG, El Shikh, Mohey, Edin, M., Singh I, Drake D, Song H ( 2012 ) . Models for vaccine assessment . no. EP20110165211 ,
Tew JG, El Shikh ME, El Sayed RM ( 2012 ) . Dendritic cells, antibodies reactive with oxLDL, and inflammation . J Dent Res vol. 91 , ( 1 ) 8 - 16 .
El Shikh MEM, Pitzalis C ( 2012 ) . Follicular dendritic cells in health and disease . Front Immunol vol. 3 ,
El Shikh MEM, Biggioggero M, El Sayed RM, Kmieciak M, Manjili MH, Szakal AK, Meroni PL, Pitzalis C et al. ( 2012 ) . REGULATION OF AUTO-ANTIBODY PRODUCTION BY PERSISTING AUTO-IMMUNE COMPLEXES ON FOLLICULAR DENDRITIC CELLS . ANNALS OF THE RHEUMATIC DISEASES . vol. 71 , A38 - A38 .
SUKUMAR S, EL SHIKH MEM, TEW JG, SANCHEZ-SCHMITZ G, MOSQUERA L, MISHKIN E, KACHURIN AM, HIGBEE R et al. ( 2011 ) . In vitro germinal centers . no. 11642938 ,
El Shikh ME, El Sayed R, Kmieciak M, Manjili M, Szakal A, Pitzalis C, Tew J ( 2011 ) . BREAKAGE OF B CELL TOLERANCE BY ANTIGENS ON FOLLICULAR DENDRITIC CELLS . RHEUMATOLOGY . vol. 50 , 51 - 51 .
Ciurtin C, Majeed Y, Naylor J, Sukumar P, English A, Emery P, Beech D, Malik N et al. ( 2011 ) . Cell receptor-ligand interaction, signalling, activation and apoptosis . Rheumatology vol. 50 , ( suppl_3 ) iii50 - iii52 .
El Shikh ME, El Sayed RM, Kmieciak M, Manjili M, Szakal A, Pitzalis C, Tew J ( 2011 ) . BREAKAGE OF B CELL TOLERANCE BY ANTIGENS ON FOLLICULAR DENDRITIC CELLS . ANNALS OF THE RHEUMATIC DISEASES . vol. 70 ,
Hanaa YA, El Shikh HH, Eglal AG, Saad AA, El Sayed RM ( 2010 ) . Fungal Secondary Metabolites: A Promising Source of Antineoplastic Drugs . Current Cancer Therapy Reviews vol. 6 , ( 3 ) 222 - 228 .
El Shikh MEM, El Sayed RM, Sukumar S, Tew JG ( 2010 ) . Activation of B cells by antigens on follicular dendritic cells . Trends Immunol vol. 31 , ( 6 ) 205 - 211 .
TEW JG, EL SHIKH MEM, SINGH I, MISHKIN E, DRAKE, III, Donald, WARREN WL ( 2010 ) . Models for vaccine assessment . no. 11819335 ,
El Shikh ME, El Sayed R, Szakal A ( 2010 ) . Breaking B cell tolerance by multimerized self antigens on follicular dendritic cells . The Journal of Immunology vol. 184 , ( Meeting Abstract Supplement )
El Shikh ME, El Sayed R, Szakal A ( 2010 ) . Breaking B cell tolerance by multimerized self antigens on follicular dendritic cells (143.7) . The Journal of Immunology vol. 184 , ( Supplement_1 ) 143.7 - 143.7 .
El Sayed R, El Shikh ME, Schenkein H ( 2010 ) . Dominance of macrophage derived IFN-{gamma} in atheromatous lesions . The Journal of Immunology vol. 184 , ( Meeting Abstract Supplement )
El Sayed R, El Shikh ME, Tew J ( 2010 ) . Dominance of macrophage derived IFN-γ in atheromatous lesions (35.3) . The Journal of Immunology vol. 184 , ( Supplement_1 ) 35.3 - 35.3 .
Gibb DR, El Shikh M, Kang D, Rowe WJ, El Sayed R, Cichy J, Tew JG ( 2010 ) . ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo . The Journal of Experimental Medicine vol. 207 , ( 3 ) 623 - 635 .
Gibb DR, El Shikh M, Kang D-J, Rowe WJ, El Sayed R, Cichy J, Dempsey PJ ( 2010 ) . ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo . Journal of Cell Biology vol. 188 , ( 4 ) i8 - i8 .
El Shikh ME, Sayed RM, Tew JG ( 2010 ) . Follicular Dendritic Cells (B Lymphocyte Stimulating) . Encyclopedia of Life Sciences, 32 Volume Set , Wiley
Wu Y, El Shikh MEM, El Sayed RM ( 2009 ) . IL-6 produced by immune complex-activated follicular dendritic cells promotes germinal center reactions, IgG responses and somatic hypermutation . Int Immunol vol. 21 , ( 6 ) 745 - 756 .
TEW JG, EL SHIKH, Mohey, Edin, M., SINGH I, MISHKIN E, SONG H ( 2009 ) . MODELS FOR VACCINE ASSESSMENT . no. EP20070872536 20070627 ,
Gibb DR, El Shikh M, Kang D, Crawford H ( 2009 ) . ADAM10 regulates B cell development and immunoglobulin production . The Journal of Immunology vol. 182 , ( 1_MeetingAbstracts )
Gibb DR, El Shikh M, Kang D-J, El Sayed R, Tew JG ( 2009 ) . ADAM10 regulates B cell development and immunoglobulin production (138.6) . The Journal of Immunology vol. 182 , ( Supplement_1 ) 138.6 - 138.6 .
El Shikh MEM, Szakal AK, Tew JG ( 2009 ) . T-independent antibody responses to T-dependent antigens: a novel follicular dendritic cell-dependent activity . J Immunol vol. 182 , ( 6 ) 3482 - 3491 .
Abu Seadah AA, El Shikh ME ( 2008 ) . RAPD typing of Aspergillus chevalieri, Aspergillus nidulans, Aspergillus tetrazonus (quadrilineatus) and their teleomorphs using 5'-d[AACGCGCAAC]-3' and 5'-d[CCCGTCAGCA]-3' primers . Mol Biol Rep vol. 35 , ( 2 ) 89 - 95 .
Shikh MEE, Sayed RE, Szakal AK ( 2008 ) . Conversion of T-dependent (TD) antigens to T-independent (TI) antigens: A novel follicular dendritic cell (FDC)-dependent activity . The FASEB Journal vol. 22 , ( 2_MeetingAbstracts )
John DV, Crisa L, Cauvi G, El Shikh ME ( 2008 ) . Primary human immune response to dendritic cell inoculation in humanized mice . The FASEB Journal vol. 22 , ( 2_MeetingAbstracts )
Sukumar S, El Shikh ME, Tew JG ( 2008 ) . Ultrastructural study of highly enriched follicular dendritic cells reveals their morphology and the periodicity of immune complex binding . Cell Tissue Res vol. 332 , ( 1 ) 89 - 99 .
Tew JG, El Shikh MEM, Singh I, Mishkin E, Drake D, Song H ( 2008 ) . Models for vaccine assessment . no. US 11/819,335 ,
Wu YZ, Sukumar S, El Shikh ME, Best AM ( 2008 ) . Immune complex-bearing follicular dendritic cells deliver a late antigenic signal that promotes somatic hypermutation . J IMMUNOL vol. 180 , ( 1 ) 281 - 290 .
El Shikh MEM, El Sayed RM, Szakal AK, Tew JG ( 2007 ) . TLR4 on follicular dendritic cells: an activation pathway that promotes accessory activity . J Immunol vol. 179 , ( 7 ) 4444 - 4450 .
Sukumar S, El Shikh MEM, Warren WL, Fahlenkamp H, Tew JG, Sanchez-Schmitz G, Mosquera L, Mishkin E et al. ( 2007 ) . In Vitro germinal centers . no. US 11/642,938 ,
El Shikh ME, El Sayed RM, Tew JG ( 2007 ) . Follicular dendritic cells stimulated by collagen type I develop dendrites and networks in vitro . Cell Tissue Res vol. 329 , ( 1 ) 81 - 89 .
Shikh MEME, Sayed RME, Wu Y ( 2007 ) . Induction of human primary antibody responses in vitro by ovalbumin (OVA) or anthrax (rPA) on dendritic cells (DCs) and follicular dendritic cells (FDCs) in temporally controlled germinal center reactions (GCRs) . The Journal of Immunology vol. 178 , ( MeetingAbstracts )
( 2007 ) . Induction of human primary antibody responses in vitro by ovalbumin (OVA) or anthrax (rPA) on dendritic cells (DCs) and follicular dendritic cells (FDCs) in temporally controlled germinal center reactions (GCRs) (47.19) . The Journal of Immunology vol. 178 , ( 1_Supplement ) s70 - s70 .
El Shikh ME, El Sayed R, Szakal AK ( 2006 ) . Follicular dendritic cell (FDC)-FcgammaRIIB engagement via immune complexes induces the activated FDC phenotype associated with secondary follicle development . Eur J Immunol vol. 36 , ( 10 ) 2715 - 2724 .
Szakal AK, Elsayed R ( 2006 ) . Influence of collagen on follicular dendritic cells to develop dendrites and reticula in vitro . JOURNAL OF IMMUNOLOGY . vol. 176 , S213 - S213 .
El Shikh ME, Elsayed R, Szakal AK ( 2006 ) . Interaction of immune complexes with Fc gamma RIIB on follicular dendritic cells upregulates Fc gamma RIIB expression as well as VCAM-1, ICAM-1 and CD320 . JOURNAL OF IMMUNOLOGY . vol. 176 , S75 - S75 .
El Shikh ME, Wu YZ, Elsayed R, Szakal AK ( 2006 ) . Interaction of poly(I : C) and LPS with toll receptors upregulates CR1/2, Fc gamma RIIB and VCAM-1 expression on follicular dendritic cells via NF-kappa B . JOURNAL OF IMMUNOLOGY . vol. 176 , S96 - S96 .
Kikuchi T, El Shikh ME, El Sayed RM, Purkall DB, Elaasser MM, Sarraf A, Barbour SE, Schenkein HA et al. . Anti-phosphorylcholine-opsonized low-density lipoprotein promotes rapid production of proinflammatory cytokines by dendritic cells and natural killer cells . Journal of Periodontal Research720 - 730 .
TEW JG, EL SHIKH MEM, SINGH I, MISHKIN E, DRAKE DIII, SONG H, WARREN W . MODELS FOR VACCINE ASSESSMENT . no. 07872536.3 ,
EL SHIKH MEM, EL SAYED R, SZAKAL AK, TEW JG, DRAKE III DR, WITTMAN V, EATRIDES J, WARREN WL . Rapid generation of t cell-independent antibody responses to t cell-dependent antigens . no. US 12/167,689 ,
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