Publications: DR Marco Gerlinger
(
2025
)
.
Clinical and experimental treatment of advanced melanoma with a focus on immunotherapy
.
Clinical & Experimental Immunology
vol.
219
,
(
1
)
Ogden S, Metic N, Leylek O, Smith EA, Berner AM, Baker A-M, Uddin I, Buzzetti M et al.
(
2025
)
.
Phenotypic heterogeneity and plasticity in colorectal cancer metastasis
.
Cell Genomics
vol.
5
,
(
7
)
Bashir U, Wang C, Smillie R, Khan AKR, Ahmed HT, Ordidge K, Power N, Gerlinger M et al.
(
2025
)
.
Deep learning for liver lesion segmentation and classification on staging CT scans of colorectal cancer patients: a multi-site technical validation study
.
Clinical Radiology
vol.
85
,
Savy T, Flanders L, Karpanasamy T
(
2025
)
.
Cancer evolution: from Darwin to the Extended Evolutionary Synthesis
.
Trends in Cancer
vol.
11
,
(
3
)
204
-
215
.
Seyedi S, Harris VK, Kapsetaki SE, Narayanan S, Saha D, Compton Z, May A, Fakir E et al.
(
2024
)
.
Resistance Management for Cancer: Lessons from Farmers
.
Cancer Research
vol.
84
,
(
22
)
3715
-
3727
.
Saeed A, Tabernero J, Parikh A, Van den Eynde M, Karthaus M, Wang G, Hecht JR
(
2024
)
.
STELLAR-303: randomized phase III study of zanzalintinib + atezolizumab in previously treated metastatic colorectal cancer
.
Future Oncology
vol.
20
,
(
24
)
1733
-
1743
.
Lane R, Mencel J, Turkes F, Challoner BR, McCafferty N, Ntellas P, Barber LJ, Rana I et al.
(
2024
)
.
124P Acquired resistance to first-line chemo- and EGFRab-therapy in mCRC: Biopsy analysis of the iSCORE trial
.
Annals of Oncology
vol.
35
,
Challoner BR, Slater SC, Sansano HB, Aresu M, Bryant A, Begum R, Rana T, Zhitkov O et al.
(
2024
)
.
30P Immunological markers of pathological and clinical and outcomes in mismatch repair deficient (MMRd) colorectal cancer (CRC)
.
Annals of Oncology
vol.
35
,
(
2024
)
.
State of the art: Targeting microsatellite instability in gastrointestinal cancers
.
Critical Reviews in Oncology/Hematology
vol.
199
,
Buzzetti M, Gerlinger M
(
2023
)
.
Assessing the toxicity of bispecific antibodies
.
Nature Biomedical Engineering
vol.
8
,
(
4
)
339
-
340
.
Newey A, Yu L, Barber LJ
(
2023
)
.
Multifactorial Remodeling of the Cancer Immunopeptidome by IFNγ
.
Cancer Research Communications
vol.
3
,
(
11
)
2345
-
2357
.
Challoner BR, Woolston A, Lau D, Buzzetti M, Fong C, Barber LJ, Anandappa G, Crux R et al.
(
2023
)
.
Genetic and immune landscape evolution in MMR‐deficient colorectal cancer
.
The Journal of Pathology
vol.
262
,
(
2
)
226
-
239
.
Mencel J, Turkes F, Barber L, Challoner B, Buzzetti M, Tran A, Chen H, McCafferty N et al.
(
2023
)
.
P-111 PD1 and LAG3 inhibition as second+ line treatment after EGFR antibody-containing therapy in RAS/BRAF wildtype, MMRp metastatic colorectal cancer
.
Annals of Oncology
vol.
34
,
s53
-
s54
.
(
2023
)
.
Pathobionts in the tumour microbiota predict survival following resection for colorectal cancer
.
Microbiome
vol.
11
,
(
1
)
Gerlinger M, Gordon A, Barber LJ, Laliotis G, Athauda A, Challoner B, Woolston A, Mansukhani S et al.
(
2023
)
.
Abstract 5591: Circulating tumor DNA for recurrence prediction and efficacy analysis in the ICONIC trial of peri-operative FLOT and avelumab (PD-L1) in localized esophago-gastric adenocarcinoma
.
Cancer Research
vol.
83
,
(
7_Supplement
)
5591
-
5591
.
McCafferty N, Fong C, Barber LJ, Woolston A, Kleftogiannis D, Cromarty S, Kidd S, Begum R
(
2023
)
.
Abstract 5593: Clonal mutation burden and evolutionary dynamics analysis in metastatic gastro-esophageal adenocarcinoma (GEA) by error corrected whole-exome circulating tumor DNA sequencing
.
Cancer Research
vol.
83
,
(
7_Supplement
)
5593
-
5593
.
(
2023
)
.
Impact of infiltrating T cell subtypes on survival and response to FLOT chemotherapy in resectable oesophagogastric adenocarcinoma (OGA)
.
Journal of Clinical Oncology
vol.
41
,
(
4_suppl
)
443
-
443
.
(
2023
)
.
Primary results of the ICONIC phase 2 trial of perioperative FLOT plus avelumab (FLOT-A) in operable oesophagogastric adenocarcinoma (OGA)
.
Journal of Clinical Oncology
vol.
41
,
(
4_suppl
)
446
-
446
.
(
2022
)
.
Proteomics uncover EPHA2 as a potential novel therapeutic target in colorectal cancer cell lines with acquired cetuximab resistance
.
Journal of Cancer Research and Clinical Oncology
vol.
149
,
(
2
)
669
-
682
.
(
2022
)
.
Advances in immunotherapy for MMR proficient colorectal cancer
.
Cancer Treatment Reviews
vol.
111
,
(
2022
)
.
A novel molecular signature identifies mixed subtypes in renal cell carcinoma with poor prognosis and independent response to immunotherapy
.
Genome Medicine
vol.
14
,
(
1
)
Dankner M, Wang Y, Fazelzad R, Johnson B, Nebhan CA, Dagogo-Jack I, Richtig G, Bracht JWP et al.
(
2022
)
.
Clinical Activity of Mitogen-Activated Protein Kinase–Targeted Therapies in Patients With Non–V600 BRAF-Mutant Tumors
.
JCO Precision Oncology
vol.
6
,
(
6
)
(
2022
)
.
Questions to guide cancer evolution as a framework for furthering progress in cancer research and sustainable patient outcomes
.
Medical Oncology
vol.
39
,
(
9
)
Challoner BR, Woolston A, Lau D, Buzzetti M, Barber LJ, Lund T, Sansano HB, von Loga K et al.
(
2022
)
.
Abstract A002: Genetic and immune landscape evolution defines subtypes of MMR deficient colorectal cancer
.
Cancer Research
.
vol.
82
,
a002
-
a002
.
Challoner BR, Woolston A, Lau D, Buzzetti M, Barber LJ, Lund T, Sansano HB, von Loga K et al.
(
2022
)
.
Abstract PR012: Genetic and immune landscape evolution defines subtypes of MMR deficient colorectal cancer
.
Cancer Research
.
vol.
82
,
pr012
-
pr012
.
(
2022
)
.
Effect of perioperative FLOT versus ECF/ECX on short-term outcomes after surgery for resectable oesophagogastric adenocarcinoma: propensity score-matched study
.
BJS Open
vol.
6
,
(
1
)
Woolston A, Barber LJ, Griffiths B, Pich O, Lopez-Bigas N, Matthews N, Rao S, Watkins D et al.
(
2021
)
.
Mutational signatures impact the evolution of anti-EGFR antibody resistance in colorectal cancer
.
Nature Ecology & Evolution
vol.
5
,
(
7
)
1024
-
1032
.
(
2021
)
.
Identifying key questions in the ecology and evolution of cancer
.
Evolutionary Applications
vol.
14
,
(
4
)
877
-
892
.
(
2021
)
.
Immunotherapy Sensitivity of Mismatch Repair-Deficient Cancer: Mutation Load Is Not Enough
.
Cancer Cell
vol.
39
,
(
1
)
16
-
18
.
Knebel FH, Barber LJ, Newey A, Kleftogiannis D, Woolston A, Fenwick K, Bettoni F, Ribeiro MFSA et al.
(
2020
)
.
Circulating Tumour DNA Sequencing Identifies a Genetic Resistance-Gap in Colorectal Cancers with Acquired Resistance to EGFR-Antibodies and Chemotherapy
.
Cancers
vol.
12
,
(
12
)
Khan K, Gonzalez-Exposito R, Cunningham D, Koh D-M, Woolston A, Barber L, Griffiths B, Kouvelakis K et al.
(
2020
)
.
Diagnostic Accuracy and Safety of Coaxial System in Oncology Patients Treated in a Specialist Cancer Center With Prospective Validation Within Clinical Trial Data
.
Frontiers in Oncology
vol.
10
,
(
2020
)
.
Comparison of a coaxial versus non-coaxial liver biopsy technique in an oncological setting: diagnostic yield, complications and seeding risk
.
European Radiology
vol.
30
,
(
12
)
6702
-
6708
.
(
2020
)
.
Defining the true impact of coronavirus disease 2019 in the at-risk population of patients with cancer
.
European Journal of Cancer
vol.
136
,
99
-
106
.
Masotti C, Knebel FH, Linck RDM, Lima J, Shimada AK, Alessi JV, Zucchetti BM, Gerlinger M et al.
(
2020
)
.
Abstract A19: Detection of ESR1 mutations in plasma cell-free DNA from metastatic ER-positive breast cancer patients resistant to hormone therapy
.
Clinical Cancer Research
vol.
26
,
(
11_Supplement
)
a19
-
a19
.
Challoner BR, von Loga K, Woolston A, Griffiths B, Sivamanoharan N, Semiannikova M, Newey A, Barber LJ et al.
(
2020
)
.
Computational Image Analysis of T-Cell Infiltrates in Resectable Gastric Cancer: Association with Survival and Molecular Subtypes
.
Journal of the National Cancer Institute
vol.
113
,
(
1
)
88
-
98
.
(
2020
)
.
Rationale and design of the POLEM trial: avelumab plus fluoropyrimidine-based chemotherapy as adjuvant treatment for stage III mismatch repair deficient or POLE exonuclease domain mutant colon cancer: a phase III randomised study
.
ESMO Open
vol.
5
,
(
1
)
(
2020
)
.
SOlar: A translational phase II study of single-agent olaparib in the treatment of advanced esophagogastric cancer
.
Journal of Clinical Oncology
vol.
38
,
(
4_suppl
)
tps471
-
tps471
.
von Loga K, Woolston A, Punta M, Barber LJ, Griffiths B, Semiannikova M, Spain G, Challoner B et al.
(
2020
)
.
Author Correction: Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer
.
Nature Communications
vol.
11
,
(
1
)
von Loga K, Woolston A, Punta M, Barber LJ, Griffiths B, Semiannikova M, Spain G, Challoner B et al.
(
2020
)
.
Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer
.
Nature Communications
vol.
11
,
(
1
)
(
2019
)
.
Targeted drugs ramp up cancer mutability
.
vol.
366
,
is.
6472
,
pp.
1452
-
1453
.
American Association for the Advancement of Science (AAAS)
Newey A, Griffiths B, Michaux J, Pak HS, Stevenson BJ, Woolston A, Semiannikova M, Spain G et al.
(
2019
)
.
Immunopeptidomics of colorectal cancer organoids reveals a sparse HLA class I neoantigen landscape and no increase in neoantigens with interferon or MEK-inhibitor treatment
.
Journal for ImmunoTherapy of Cancer
vol.
7
,
(
1
)
(
2019
)
.
661TiP iSCORE: Immunotherapy sequencing in colon and rectal cancer
.
Annals of Oncology
vol.
30
,
Davidson M, Mansukhani S, Starling N, Chau I, Watkins D, Cunningham D, Rao S, Lazaro-Alcausi R et al.
(
2019
)
.
674PD Perioperative FLOT + anti-PD-L1 avelumab (FLOT-A) chemo-immunotherapy in resectable oesophagogastric adenocarcinoma (OGA): Safety and biomarker data from the ICONIC trial safety run-in
.
Annals of Oncology
vol.
30
,
Woolston A, Khan K, Spain G, Barber LJ, Griffiths B, Gonzalez-Exposito R, Hornsteiner L, Punta M et al.
(
2019
)
.
Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer
.
Cancer Cell
vol.
36
,
(
1
)
35
-
50.e9
.
Davidson M, Barber LJ, Woolston A, Cafferkey C, Mansukhani S, Griffiths B, Moorcraft S-Y, Rana I et al.
(
2019
)
.
Detecting and Tracking Circulating Tumour DNA Copy Number Profiles during First Line Chemotherapy in Oesophagogastric Adenocarcinoma
.
Cancers
vol.
11
,
(
5
)
Gonzalez-Exposito R, Semiannikova M, Griffiths B, Khan K, Woolston A, Spain G, von Loga K, Challoner B et al.
(
2019
)
.
CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids
.
Journal for ImmunoTherapy of Cancer
vol.
7
,
(
1
)
Exposito RG, Semmianikova M, Griffiths B, Khan KH, Barber LJ, Woolston A, Spain G, von Loga K et al.
(
2019
)
.
CEA expression patterns determine response and resistance to the CEA-TCB bispecific immunotherapy antibody in colorectal cancer patient derived organoids
.
Journal of Clinical Oncology
vol.
37
,
(
4_suppl
)
535
-
535
.
Mansukhani S, Barber LJ, Kleftogiannis D, Moorcraft SY, Davidson M, Woolston A, Proszek PZ, Griffiths B et al.
(
2018
)
.
Ultra-Sensitive Mutation Detection and Genome-Wide DNA Copy Number Reconstruction by Error-Corrected Circulating Tumor DNA Sequencing
.
Clinical Chemistry
vol.
64
,
(
11
)
1626
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1635
.
(
2018
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Efficacy and Cardiotoxic Safety Profile of Raltitrexed in Fluoropyrimidines-Pretreated or High-Risk Cardiac Patients With GI Malignancies: Large Single-Center Experience
.
Clinical Colorectal Cancer
vol.
18
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(
1
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64
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71.e1
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2018
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Metastasis Seeding Cells: Lone Invaders or Mass Migrators?
.
Clinical Cancer Research
vol.
24
,
(
9
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2032
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2034
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(
2018
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Complications and seeding risk after percutaneous liver biopsy in an oncological setting
.
Journal of Clinical Oncology
.
vol.
36
,
246
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246
.
(
2018
)
.
Percutaneous radiofrequency versus microwave ablation for the treatment of colorectal liver metastases
.
Journal of Clinical Oncology
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vol.
36
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401
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401
.
(
2018
)
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Investigating the feasibility of tumour molecular profiling in gastrointestinal malignancies in routine clinical practice
.
Annals of Oncology
vol.
29
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1
)
230
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236
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(
2017
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Circulating tumour DNA, a promising biomarker for the management of colorectal cancer
.
Critical Reviews in Oncology/Hematology
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122
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72
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82
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(
2017
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Critical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer
.
Gut
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67
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1
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2017
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Treatment and Survival Outcome of BRAF-Mutated Metastatic Colorectal Cancer: A Retrospective Matched Case-Control Study
.
Clinical Colorectal Cancer
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17
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1
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e69
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e76
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Maley CC, Aktipis A, Graham TA, Sottoriva A, Boddy AM, Janiszewska M, Silva AS, Gerlinger M et al.
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2017
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Classifying the evolutionary and ecological features of neoplasms
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Nature Reviews Cancer
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17
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10
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605
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619
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2017
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Cancer (r)evolution
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Nature Ecology & Evolution
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1
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8
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1051
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1052
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2017
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Intratumoural evolutionary landscape of high-risk prostate cancer: the PROGENY study of genomic and immune parameters
.
Annals of Oncology
vol.
28
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10
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2472
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2480
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Davies MN, Barber LJ, Spain G, Lopes F, Loga KV, Griffiths B, Woolston A, Alpar D et al.
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2017
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Abstract 422: Lymph node metastasis evolution drives immune evasion and targeted therapy resistance in gastro-esophageal adenocarcinomas (GEAs)
.
Cancer Research
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422
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PD-015 Diagnostic accuracy and safety of coaxial core-needle biopsy (CNB) system in a predominanty gastrointestinal oncology patient population, treated at the Royal Marsden (RM) Hospital
.
Annals of Oncology
vol.
28
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Gerber T, Barber L, Huetter S, Bogen D, Davies M, Assiotis I, Berneder M, Abbasi R et al.
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2017
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Visualization of intra tumor heterogeneity by simultaneous analysis of tumor and liquid biopsy samples in stage M neuroblastomas
.
Klinische Pädiatrie
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Conference:
30. Jahrestagung der Kind-Philipp-Stiftung für pädiatrisch-onkologische Forschung
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2016
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Heterogeneous response and progression patterns reveal phenotypic heterogeneity of tyrosine kinase inhibitor response in metastatic renal cell carcinoma
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BMC Medicine
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1
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2016
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A prospective translational study investigating molecular predictors of resistance and response to regorafenib (REG) monotherapy in RAS mutant (mt) metastatic colorectal cancer (mCRC): Initial magnetic resonance imaging (MRI) sub-study result
.
Journal of Clinical Oncology
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34
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Lipinski KA, Barber LJ, Davies MN, Ashenden M
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Cancer Evolution and the Limits of Predictability in Precision Cancer Medicine
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P-309 PROSPECT-R: A PROSPECTive translational study investigating molecular predictors of resistance and response to Regorafenib (REG) monotherapy in RAS mutant (mt) metastatic colorectal cancer (CRC)
.
Annals of Oncology
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26
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2015
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Glioblastoma adaptation traced through decline of an IDH1 clonal driver and macro-evolution of a double-minute chromosome
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5
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880
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887
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SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair
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Translating Seminoma Genomic Landscapes into Clinical Practice
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Intratumor heterogeneity of DNA copy number aberrations in gastric and oesophageal adenocarcinomas
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Journal of Clinical Oncology
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Dissecting cancer evolution at the macro-heterogeneity and micro-heterogeneity scale
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Spatial and temporal diversity in genomic instability processes defines lung cancer evolution
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Cancer: Evolution Within a Lifetime
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The promise of circulating tumor cell analysis in cancer management
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Development of synchronous VHL syndrome tumors reveals contingencies and constraints to tumor evolution
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Systematic Evaluation of the Prognostic Impact and Intratumour Heterogeneity of Clear Cell Renal Cell Carcinoma Biomarkers
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Intratumour Heterogeneity in Urologic Cancers: From Molecular Evidence to Clinical Implications
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Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing
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The Effect of VEGF-Targeted Therapy on Biomarker Expression in Sequential Tissue from Patients with Metastatic Clear Cell Renal Cancer
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Computational optimisation of targeted DNA sequencing for cancer detection
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Ultra‐deep T cell receptor sequencing reveals the complexity and intratumour heterogeneity of T cell clones in renal cell carcinomas
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Acquired Resistance to Crizotinib from a Mutation in CD74–ROS1
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Acquired resistance to crizotinib from a mutation in CD74-ROS1
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Parallel evolution of tumour subclones mimics diversity between tumours
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Prognostic and Predictive Markers in Metastatic Renal Cell Carcinoma
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Genome‐wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target
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Intratumor Heterogeneity: Seeing the Wood for the Trees
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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing
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How Darwinian models inform therapeutic failure initiated by clonal heterogeneity in cancer medicine
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Elevated LDH predicts poor outcome of recurrent germ cell tumours treated with dose dense chemotherapy
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European Journal of Cancer
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Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets
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Anti-cancer drug resistance: Understanding the mechanisms through the use of integrative genomics and functional RNA interference
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